mihirhirave/entity_extraction_ade_v2_with_validation

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NCSE, an epileptic disorder in which typical convulsive activity is absent, has previously been reported in only 4 patients receiving ifosfamide.	[ { "ade": "NCSE", "drug": "ifosfamide" } ]
Enoxaparin-induced generalized exanthem.	[ { "ade": "generalized exanthem", "drug": "Enoxaparin" } ]
CONCLUSION: Tamoxifen may cause malignant transformation of endometriosis through atypical endometriosis even in the postmenopausal state.	[ { "ade": "malignant transformation of endometriosis", "drug": "Tamoxifen" } ]
The development of systemic lupus erythematosus (SLE) after 38 months of therapy with recombinant human interferon gamma (rIFN-gamma) was observed in a patient with rheumatoid arthritis.	[ { "ade": "SLE", "drug": "recombinant human interferon gamma" }, { "ade": "systemic lupus erythematosus", "drug": "rIFN-gamma" }, { "ade": "systemic lupus erythematosus", "drug": "recombinant human interferon gamma" }, { "ade": "SLE", "drug": "rIFN-gamma" } ]
Acute pancreatitis is a known, although rare, complication of mesalamine treatment.	[ { "ade": "Acute pancreatitis", "drug": "mesalamine" } ]
Acute esmolol toxicity may be self-limiting because of its extremely short half-life.	[ { "ade": "esmolol toxicity", "drug": "esmolol" } ]
Five days after the fourth dose of vincristine, she presented with bilateral ptosis.	[ { "ade": "bilateral ptosis", "drug": "vincristine" } ]
We report a case of chronic use of HCQ associated with torsade de pointes.	[ { "ade": "torsade de pointes", "drug": "HCQ" } ]
A case of heatstroke is reported in a 32-year-old man diagnosed with schizophrenia and on clozapine monotherapy.	[ { "ade": "heatstroke", "drug": "clozapine" } ]
The sub-conjunctival haematoma in a patient receiving warfarin can pose a significant management challenge.	[ { "ade": "sub-conjunctival haematoma", "drug": "warfarin" } ]
Pneumonitis is emerging as one of the most unpredictable and potentially serious, adverse effects of treatment with MTX.	[ { "ade": "Pneumonitis", "drug": "MTX" } ]
Primary CNS lymphoma complicating treatment of myasthenia gravis with mycophenolate mofetil.	[ { "ade": "CNS lymphoma", "drug": "mycophenolate mofetil" } ]
Their parkinsonism improved on discontinuation of metoclopramide therapy.	[ { "ade": "parkinsonism", "drug": "metoclopramide" } ]
Nitrendipine is an experimental calcium channel blocking agent that also appears to cause the side effect of drug-induced gingival hyperplasia.	[ { "ade": "gingival hyperplasia", "drug": "Nitrendipine" } ]
However, because diphenhydramine also exhibits type IA sodium channel blockade, cardiac toxicity is also possible.	[ { "ade": "cardiac toxicity", "drug": "diphenhydramine" } ]
Oxcarbazepine-associated angioedema manifested by swelling of the face, eyes, lips, or tongue or difficulty swallowing or breathing (or both) is a rare but potentially life-threatening reaction for which early recognition and management are vital.	[ { "ade": "angioedema", "drug": "Oxcarbazepine" } ]
This case extends the spectrum of fludarabine pulmonary toxicity to include pulmonary nodules.	[ { "ade": "pulmonary nodules", "drug": "fludarabine" }, { "ade": "pulmonary toxicity", "drug": "fludarabine" } ]
We report on a 37-year-old female who complained of moderate hair loss during paroxetine treatment.	[ { "ade": "hair loss", "drug": "paroxetine" } ]
Hemodialysis was also shown to reverse ifosfamide-related neurotoxicity.	[ { "ade": "neurotoxicity", "drug": "ifosfamide" } ]
Hyperglycemia and diabetic coma: possible relationship to diuretic-propranolol therapy.	[ { "ade": "Hyperglycemia", "drug": "propranolol" }, { "ade": "diabetic coma", "drug": "propranolol" } ]
We report on three cases wherein treatment of dexmedetomidine-induced bradycardia with i.v. glycopyrrolate (5.0 microg/kg) not only resulting in resolution of bradycardia but also resulting in an exaggerated increase of arterial blood pressure.	[ { "ade": "bradycardia", "drug": "dexmedetomidine" }, { "ade": "exaggerated increase of arterial blood pressure", "drug": "glycopyrrolate" } ]
She was thus diagnosed as having AZ intoxication.	[ { "ade": "AZ intoxication", "drug": "AZ" } ]
Young children undergoing cisplatin chemotherapy are known to be at risk for progressive sensorineural hearing loss.	[ { "ade": "progressive sensorineural hearing loss", "drug": "cisplatin" } ]
Fatal digoxin poisoning: an unsuccessful resuscitation with use of digoxin-immune Fab.	[ { "ade": "Fatal digoxin poisoning", "drug": "digoxin" } ]
Presently, treatment of acute ibuprofen intoxication with complications requires supportive therapy until the symptoms resolve over 24 to 48 hours.	[ { "ade": "ibuprofen intoxication", "drug": "ibuprofen" } ]
INTERPRETATION: When high doses of fluticasone propionate are used, growth may be retarded and adrenal suppression may occur.	[ { "ade": "growth may be retarded", "drug": "fluticasone propionate" }, { "ade": "adrenal suppression", "drug": "fluticasone propionate" } ]
The patient was diagnosed with carbamazepine toxicity related to the introduction of ritonavir.	[ { "ade": "carbamazepine toxicity", "drug": "ritonavir" }, { "ade": "carbamazepine toxicity", "drug": "carbamazepine" } ]
Pulmonary edema as a delayed complication of ritodrine therapy.	[ { "ade": "Pulmonary edema", "drug": "ritodrine" } ]
A 52-year-old woman developed symmetric sensorimotor polyneuropathy and cerebellar syndrome after 24 months of amiodarone treatment.	[ { "ade": "symmetric sensorimotor polyneuropathy", "drug": "amiodarone" }, { "ade": "cerebellar syndrome", "drug": "amiodarone" } ]
Phenolphthalein-induced toxic epidermal necrolysis.	[ { "ade": "toxic epidermal necrolysis", "drug": "Phenolphthalein" } ]
While doxorubicin was administered, the patient presented thoracic pain and breathing distress due to superior vena cava perforation by the central catheter and subsequent extravasation of the drug into the mediastinum.	[ { "ade": "breathing distress", "drug": "doxorubicin" }, { "ade": "thoracic pain", "drug": "doxorubicin" } ]
Sulfasalazine-induced hypersensitivity syndrome and hemophagocytic syndrome associated with reactivation of Epstein-Barr virus.	[ { "ade": "hemophagocytic syndrome", "drug": "Sulfasalazine" }, { "ade": "hypersensitivity syndrome", "drug": "Sulfasalazine" } ]
The authors presented a case of pulmonary hypertension during lithium therapy, while she has been on lithium for 6 years.	[ { "ade": "pulmonary hypertension", "drug": "lithium" } ]
In conclusion, RSDS is a relevant osteoarticular complication in patients receiving either anticalcineurinic drug (CyA or tacrolimus), even under monotherapy or with a low steroid dose.	[ { "ade": "RSDS", "drug": "tacrolimus" }, { "ade": "RSDS", "drug": "CyA" } ]
We report two cases of cerebrospinal fluid eosinophilia (CSFE) secondary to the intraventricular administration of vancomycin.	[ { "ade": "CSFE", "drug": "vancomycin" }, { "ade": "cerebrospinal fluid eosinophilia", "drug": "vancomycin" } ]
A 77-year-old man developed ankle, hand, and facial swelling 2 weeks after starting rosiglitazone.	[ { "ade": "ankle, hand, and facial swelling", "drug": "rosiglitazone" } ]
Fatal intravascular autoimmune hemolytic anemia after fludarabine treatment for chronic lymphocytic leukemia.	[ { "ade": "Fatal intravascular autoimmune hemolytic anemia", "drug": "fludarabine" } ]
Slow acetylators, who comprise roughly 50% of the South African population, are likely to develop clinical and biochemical features of phenytoin toxicity when this drug is given together with antituberculosis therapy.	[ { "ade": "phenytoin toxicity", "drug": "phenytoin" } ]
Drug induced polymyositis secondary to leuprolide acetate (Lupron) therapy for prostate carcinoma.	[ { "ade": "polymyositis", "drug": "Lupron" }, { "ade": "polymyositis", "drug": "leuprolide acetate" } ]
In each of the three reported patients, alteration of eyelid appearance with deepening of the lid sulcus was evident as the result of topical bimatoprost therapy.	[ { "ade": "deepening of the lid sulcus", "drug": "bimatoprost" }, { "ade": "alteration of eyelid appearance", "drug": "bimatoprost" } ]
CONCLUSIONS: For all patients with vancomycin-induced neutropenia, possible cross-reactivity of teicoplanin should be monitored.	[ { "ade": "neutropenia", "drug": "vancomycin" } ]
This is the first report of an adverse effect of fetal renal circulation by maternal ingestion of nimesulide.	[ { "ade": "adverse effect of fetal renal circulation", "drug": "nimesulide" } ]
This case report describes the development of asymptomatic visual field defects (VFDs) in a psychiatric patient with bipolar disorder receiving adjunctive tiagabine treatment.	[ { "ade": "VFDs", "drug": "tiagabine" }, { "ade": "visual field defects", "drug": "tiagabine" } ]
Unusual hypersensitivity to warfarin in a critically ill patient.	[ { "ade": "hypersensitivity", "drug": "warfarin" } ]
Cyclosporin side effects included hirsutism, hypertension, increased blood levels of urea and creatinine, and abnormalities in liver function tests.	[ { "ade": "abnormalities in liver function tests", "drug": "Cyclosporin" }, { "ade": "hypertension", "drug": "Cyclosporin" }, { "ade": "increased blood levels of urea and creatinine", "drug": "Cyclosporin" }, { "ade": "hirsutism", "drug": "Cyclosporin" } ]
Amiodarone was the third drug to induce AVT in this patient; she received 200 mg/day six days per week for six months.	[ { "ade": "AVT", "drug": "Amiodarone" } ]
Development of sarcoidosis during interferon alpha 2b and ribavirin combination therapy for chronic hepatitis C--a case report and review of the literature.	[ { "ade": "sarcoidosis", "drug": "ribavirin" }, { "ade": "sarcoidosis", "drug": "interferon alpha 2b" } ]
We present a case of significant over-anticoagulation temporally associated with a bout of protracted diarrhea in a patient on warfarin therapy.	[ { "ade": "diarrhea", "drug": "warfarin" }, { "ade": "over-anticoagulation", "drug": "warfarin" } ]
RESULTS: Both patients experienced a previously unreported side effect--falling backward--associated with bupropion use.	[ { "ade": "falling backward", "drug": "bupropion" } ]
Beneficial effect of low-dose mianserin on fluvoxamine-induced akathisia in an obsessive-compulsive patient.	[ { "ade": "akathisia", "drug": "fluvoxamine" } ]
A 21-year-old man with Tourette's syndrome, pedophilia, Asperger's syndrome, and multiple sclerosis experienced seizures after receiving therapy with interferon beta-1a.	[ { "ade": "seizures", "drug": "interferon beta-1a" } ]
Carboplatin hypersensitivity presenting as coronary vasospasm - a case report.	[ { "ade": "coronary vasospasm", "drug": "Carboplatin" } ]
Mesalamine may cause hypersensitivity pneumonitis in patients with Crohn's disease.	[ { "ade": "hypersensitivity pneumonitis", "drug": "Mesalamine" } ]
Pulmonary oedema after hexoprenaline administration in preterm labour.	[ { "ade": "Pulmonary oedema", "drug": "hexoprenaline" } ]
However, several case reports have suggested that clozapine could also cause TD.	[ { "ade": "TD", "drug": "clozapine" } ]
Levofloxacin-induced delirium with psychotic features.	[ { "ade": "delirium with psychotic features", "drug": "Levofloxacin" } ]
Argatroban for heparin-induced thrombocytopenia in hepato-renal failure and CVVHD.	[ { "ade": "thrombocytopenia", "drug": "heparin" } ]
We describe a patient who presented with bloody diarrhoea after 15 mg meloxicam daily for 10 days for osteoarthritis.	[ { "ade": "bloody diarrhoea", "drug": "meloxicam" } ]
BACKGROUND: Aphthous stomatitis, a common mucocutaneous disorder, is a well accepted complication of sirolimus therapy.	[ { "ade": "Aphthous stomatitis", "drug": "sirolimus" } ]
One should therefore be aware of possible extrapyramidal side effects with olanzapine that are reduced compared to classical neuroleptic drugs but not completely eliminated.	[ { "ade": "extrapyramidal side effects", "drug": "olanzapine" } ]
TREATMENT/OUTCOME: Standard anti-tuberculosis therapy was administered but was complicated by interaction with cyclosporine and drug-induced cholestasis.	[ { "ade": "cholestasis", "drug": "cyclosporine" } ]
A review of the literature revealed two other cases of hepatic angiosarcoma in patients after long-term cyclophosphamide treatment.	[ { "ade": "hepatic angiosarcoma", "drug": "cyclophosphamide" } ]
Persistent light reactivity from systemic quinine.	[ { "ade": "Persistent light reactivity", "drug": "quinine" } ]
Transient trazodone-induced hypomanic symptoms occurred in three depressed patients.	[ { "ade": "hypomanic symptoms", "drug": "trazodone" } ]
Nephrotic range pseudoproteinuria in a tolmetin-treated patient.	[ { "ade": "Nephrotic range pseudoproteinuria", "drug": "tolmetin" } ]
In this article, we describe a Japanese patient with severe interstitial pneumonia probably caused by sorafenib treatment for metastatic renal cell carcinoma.	[ { "ade": "severe interstitial pneumonia", "drug": "sorafenib" } ]
Chronic fentanyl application induces adrenocortical insufficiency.	[ { "ade": "adrenocortical insufficiency", "drug": "fentanyl" } ]
Fatal toxic epidermal necrolysis related to lamotrigine administration.	[ { "ade": "Fatal toxic epidermal necrolysis", "drug": "lamotrigine" } ]
Intrahepatic cholestasis and cutaneous bullae associated with glibenclamide therapy.	[ { "ade": "Intrahepatic cholestasis", "drug": "glibenclamide" }, { "ade": "cutaneous bullae", "drug": "glibenclamide" } ]
Hepatic damage after danazol treatment.	[ { "ade": "Hepatic damage", "drug": "danazol" } ]
We report an allogeneic bone marrow transplant recipient who developed CMV infection refractory to sequential therapy with ganciclovir, foscarnet, and cidofovir.	[ { "ade": "CMV infection", "drug": "foscarnet" }, { "ade": "CMV infection", "drug": "ganciclovir" }, { "ade": "CMV infection", "drug": "cidofovir" } ]
Intrathecal methotrexate-induced acute cerebellar syndrome.	[ { "ade": "acute cerebellar syndrome", "drug": "methotrexate" } ]
The potential role of propranolol in inducing central nervous system disturbances is emphasized, and the literature on the subject is reviewed.	[ { "ade": "central nervous system disturbances", "drug": "propranolol" } ]
This report highlights a case of drug-induced dysphagia in a patient receiving haloperidol for obsessive nocturnal thoughts and auditory disturbances.	[ { "ade": "dysphagia", "drug": "haloperidol" } ]
Multiple myeloma complicated by congestive heart failure following first administration of recombinant alpha-interferon.	[ { "ade": "congestive heart failure", "drug": "recombinant alpha-interferon" } ]
This represents the first report of nonconvulsive status epilepticus induced by ifosfamide.	[ { "ade": "nonconvulsive status epilepticus", "drug": "ifosfamide" } ]
A teenage girl with crescentic glomerulonephritis had antineutrophil cytoplasmic antibody (ANCA) detected after she had received propylthiouracil (PTU) for hyperthyroidism without cutaneous vasculitis.	[ { "ade": "antineutrophil cytoplasmic antibody", "drug": "PTU" }, { "ade": "antineutrophil cytoplasmic antibody", "drug": "propylthiouracil" } ]
Due to the severity of the rash, temozolomide was permanently discontinued.	[ { "ade": "rash", "drug": "temozolomide" } ]
After ruling out a hydrotelluric source of fluorine, the patient's fluorosis was linked to chronic use of niflumic acid, following the publication in 1978 of the 2 previously reported cases affected by this drug.	[ { "ade": "fluorosis", "drug": "niflumic acid" } ]
Ticlopidine-induced marrow aplasia treated with cyclosporine.	[ { "ade": "marrow aplasia", "drug": "Ticlopidine" } ]
Physicians should be aware of the risk of severe AIHA in CLL patients with a history of AIHA or positivation of the DAT during previous fludarabine administration, or in case of secondary fixation of complement to the red cell membrane occurring during fludarabine treatment.	[ { "ade": "positivation of the DAT", "drug": "fludarabine" }, { "ade": "AIHA", "drug": "fludarabine" } ]
Although isradipine has been associated with hepatocellular injury, there are no reports of fulminant liver failure with this agent, and our patient had been treated for >2 years without signs of toxicity.	[ { "ade": "hepatocellular injury", "drug": "isradipine" } ]
Severe corneal toxicity after topical fluoroquinolone therapy: report of two cases.	[ { "ade": "Severe corneal toxicity", "drug": "fluoroquinolone" } ]
A 57-year-old woman presented with a 3-week history of dysphagia for solids, 6 months after starting treatment with nifedipine.	[ { "ade": "dysphagia for solids", "drug": "nifedipine" } ]
RESULTS: Both cases presented here describe corneal ulcers that persisted and showed signs of worsening during weeks of frequent topical dosing with moxifloxacin.	[ { "ade": "corneal ulcers", "drug": "moxifloxacin" } ]
Recognition of a potential drug-induced Fanconi syndrome is important when managing pediatric oncology patients previously treated with ifosfamide.	[ { "ade": "Fanconi syndrome", "drug": "ifosfamide" } ]
The occurrence of a myocardial infarction is reported after chemotherapy containing etoposide, in a man with no risk factors for coronary heart disease.	[ { "ade": "myocardial infarction", "drug": "etoposide" } ]
CASE SUMMARIES: Two patients who received ifosfamide-containing chemotherapy developed NCSE.	[ { "ade": "NCSE", "drug": "ifosfamide" } ]
Even though only a few cases of this adverse event have been reported in the literature, severe docetaxel-induced pulmonary toxicity needs to be considered in the differential diagnosis when such patients present with respiratory symptoms.	[ { "ade": "pulmonary toxicity", "drug": "docetaxel" } ]
In the following case report, a patient developed acute interstitial nephritis with renal failure and exfoliative dermatitis following ampicillin therapy.	[ { "ade": "acute interstitial nephritis", "drug": "ampicillin" }, { "ade": "exfoliative dermatitis", "drug": "ampicillin" }, { "ade": "renal failure", "drug": "ampicillin" } ]
Interstitial pneumopathy and low-dosage amiodarone.	[ { "ade": "Interstitial pneumopathy", "drug": "amiodarone" } ]
OBJECTIVE: To report on the possible development of serotonin syndrome in a patient receiving clomipramine after clozapine was withdrawn from the treatment regimen.	[ { "ade": "serotonin syndrome", "drug": "clomipramine" }, { "ade": "serotonin syndrome", "drug": "clozapine" } ]
We report two cases of neutropenia following captopril use in cardiac patients with trisomy 21.	[ { "ade": "neutropenia", "drug": "captopril" } ]
When the disease recurred conventional amphotericin B was used again, but had to be stopped because of severe side effects.	[ { "ade": "severe side effects", "drug": "amphotericin B" } ]
One patient developed severe hyponatremia with serum Na+ of 108 mEq/L when hydrochlorothiazide was given to control hypertension.	[ { "ade": "severe hyponatremia", "drug": "hydrochlorothiazide" } ]
The mechanism of RTA induced by FK506 has not yet been clearly elucidated.	[ { "ade": "RTA", "drug": "FK506" } ]
We describe a patient with acute leukemia who developed Horner's syndrome and a severe demyelinating peripheral neuropathy leading to death after receiving high-dose cytosine arabinoside.	[ { "ade": "severe demyelinating peripheral neuropathy", "drug": "cytosine arabinoside" }, { "ade": "death", "drug": "cytosine arabinoside" }, { "ade": "Horner's syndrome", "drug": "cytosine arabinoside" } ]
Three male patients aged 78-83 years are presented, in whom severe hepatotoxic reactions emerged after CPA administration.	[ { "ade": "severe hepatotoxic reactions", "drug": "CPA" } ]
The literature is also reviewed for ARF associated with mannitol infusion in patients who received dialysis and those who did not receive dialysis; and the possible mechanism(s) of mannitol nephrotoxicity are discussed.	[ { "ade": "nephrotoxicity", "drug": "mannitol" }, { "ade": "ARF", "drug": "mannitol" } ]
Captopril is an angiotensin-converting enzyme (ACE) inhibitor and their cutaneous side-effects are documented, but little has been published concerning the usefulness of patch test when they occur.	[ { "ade": "cutaneous side-effects", "drug": "Captopril" } ]

NCSE, an epileptic disorder in which typical convulsive activity is absent, has previously been reported in only 4 patients receiving ifosfamide.

[ { "ade": "NCSE", "drug": "ifosfamide" } ]

Enoxaparin-induced generalized exanthem.

[ { "ade": "generalized exanthem", "drug": "Enoxaparin" } ]

CONCLUSION: Tamoxifen may cause malignant transformation of endometriosis through atypical endometriosis even in the postmenopausal state.

[ { "ade": "malignant transformation of endometriosis", "drug": "Tamoxifen" } ]

The development of systemic lupus erythematosus (SLE) after 38 months of therapy with recombinant human interferon gamma (rIFN-gamma) was observed in a patient with rheumatoid arthritis.

[ { "ade": "SLE", "drug": "recombinant human interferon gamma" }, { "ade": "systemic lupus erythematosus", "drug": "rIFN-gamma" }, { "ade": "systemic lupus erythematosus", "drug": "recombinant human interferon gamma" }, { "ade": "SLE", "drug": "rIFN-gamma" } ]

Acute pancreatitis is a known, although rare, complication of mesalamine treatment.

[ { "ade": "Acute pancreatitis", "drug": "mesalamine" } ]

Acute esmolol toxicity may be self-limiting because of its extremely short half-life.

[ { "ade": "esmolol toxicity", "drug": "esmolol" } ]

Five days after the fourth dose of vincristine, she presented with bilateral ptosis.

[ { "ade": "bilateral ptosis", "drug": "vincristine" } ]

We report a case of chronic use of HCQ associated with torsade de pointes.

[ { "ade": "torsade de pointes", "drug": "HCQ" } ]

A case of heatstroke is reported in a 32-year-old man diagnosed with schizophrenia and on clozapine monotherapy.

[ { "ade": "heatstroke", "drug": "clozapine" } ]

The sub-conjunctival haematoma in a patient receiving warfarin can pose a significant management challenge.

[ { "ade": "sub-conjunctival haematoma", "drug": "warfarin" } ]

Pneumonitis is emerging as one of the most unpredictable and potentially serious, adverse effects of treatment with MTX.

[ { "ade": "Pneumonitis", "drug": "MTX" } ]

Primary CNS lymphoma complicating treatment of myasthenia gravis with mycophenolate mofetil.

[ { "ade": "CNS lymphoma", "drug": "mycophenolate mofetil" } ]

Their parkinsonism improved on discontinuation of metoclopramide therapy.

[ { "ade": "parkinsonism", "drug": "metoclopramide" } ]

Nitrendipine is an experimental calcium channel blocking agent that also appears to cause the side effect of drug-induced gingival hyperplasia.

[ { "ade": "gingival hyperplasia", "drug": "Nitrendipine" } ]

However, because diphenhydramine also exhibits type IA sodium channel blockade, cardiac toxicity is also possible.

[ { "ade": "cardiac toxicity", "drug": "diphenhydramine" } ]

Oxcarbazepine-associated angioedema manifested by swelling of the face, eyes, lips, or tongue or difficulty swallowing or breathing (or both) is a rare but potentially life-threatening reaction for which early recognition and management are vital.

[ { "ade": "angioedema", "drug": "Oxcarbazepine" } ]

This case extends the spectrum of fludarabine pulmonary toxicity to include pulmonary nodules.

[ { "ade": "pulmonary nodules", "drug": "fludarabine" }, { "ade": "pulmonary toxicity", "drug": "fludarabine" } ]

We report on a 37-year-old female who complained of moderate hair loss during paroxetine treatment.

[ { "ade": "hair loss", "drug": "paroxetine" } ]

Hemodialysis was also shown to reverse ifosfamide-related neurotoxicity.

[ { "ade": "neurotoxicity", "drug": "ifosfamide" } ]

Hyperglycemia and diabetic coma: possible relationship to diuretic-propranolol therapy.

[ { "ade": "Hyperglycemia", "drug": "propranolol" }, { "ade": "diabetic coma", "drug": "propranolol" } ]

We report on three cases wherein treatment of dexmedetomidine-induced bradycardia with i.v. glycopyrrolate (5.0 microg/kg) not only resulting in resolution of bradycardia but also resulting in an exaggerated increase of arterial blood pressure.

[ { "ade": "bradycardia", "drug": "dexmedetomidine" }, { "ade": "exaggerated increase of arterial blood pressure", "drug": "glycopyrrolate" } ]

She was thus diagnosed as having AZ intoxication.

[ { "ade": "AZ intoxication", "drug": "AZ" } ]

Young children undergoing cisplatin chemotherapy are known to be at risk for progressive sensorineural hearing loss.

[ { "ade": "progressive sensorineural hearing loss", "drug": "cisplatin" } ]

Fatal digoxin poisoning: an unsuccessful resuscitation with use of digoxin-immune Fab.

[ { "ade": "Fatal digoxin poisoning", "drug": "digoxin" } ]

Presently, treatment of acute ibuprofen intoxication with complications requires supportive therapy until the symptoms resolve over 24 to 48 hours.

[ { "ade": "ibuprofen intoxication", "drug": "ibuprofen" } ]

INTERPRETATION: When high doses of fluticasone propionate are used, growth may be retarded and adrenal suppression may occur.

[ { "ade": "growth may be retarded", "drug": "fluticasone propionate" }, { "ade": "adrenal suppression", "drug": "fluticasone propionate" } ]

The patient was diagnosed with carbamazepine toxicity related to the introduction of ritonavir.

[ { "ade": "carbamazepine toxicity", "drug": "ritonavir" }, { "ade": "carbamazepine toxicity", "drug": "carbamazepine" } ]

Pulmonary edema as a delayed complication of ritodrine therapy.

[ { "ade": "Pulmonary edema", "drug": "ritodrine" } ]

A 52-year-old woman developed symmetric sensorimotor polyneuropathy and cerebellar syndrome after 24 months of amiodarone treatment.

[ { "ade": "symmetric sensorimotor polyneuropathy", "drug": "amiodarone" }, { "ade": "cerebellar syndrome", "drug": "amiodarone" } ]

Phenolphthalein-induced toxic epidermal necrolysis.

[ { "ade": "toxic epidermal necrolysis", "drug": "Phenolphthalein" } ]

While doxorubicin was administered, the patient presented thoracic pain and breathing distress due to superior vena cava perforation by the central catheter and subsequent extravasation of the drug into the mediastinum.

[ { "ade": "breathing distress", "drug": "doxorubicin" }, { "ade": "thoracic pain", "drug": "doxorubicin" } ]

Sulfasalazine-induced hypersensitivity syndrome and hemophagocytic syndrome associated with reactivation of Epstein-Barr virus.

[ { "ade": "hemophagocytic syndrome", "drug": "Sulfasalazine" }, { "ade": "hypersensitivity syndrome", "drug": "Sulfasalazine" } ]

The authors presented a case of pulmonary hypertension during lithium therapy, while she has been on lithium for 6 years.

[ { "ade": "pulmonary hypertension", "drug": "lithium" } ]

In conclusion, RSDS is a relevant osteoarticular complication in patients receiving either anticalcineurinic drug (CyA or tacrolimus), even under monotherapy or with a low steroid dose.

[ { "ade": "RSDS", "drug": "tacrolimus" }, { "ade": "RSDS", "drug": "CyA" } ]

We report two cases of cerebrospinal fluid eosinophilia (CSFE) secondary to the intraventricular administration of vancomycin.

[ { "ade": "CSFE", "drug": "vancomycin" }, { "ade": "cerebrospinal fluid eosinophilia", "drug": "vancomycin" } ]

A 77-year-old man developed ankle, hand, and facial swelling 2 weeks after starting rosiglitazone.

[ { "ade": "ankle, hand, and facial swelling", "drug": "rosiglitazone" } ]

Fatal intravascular autoimmune hemolytic anemia after fludarabine treatment for chronic lymphocytic leukemia.

[ { "ade": "Fatal intravascular autoimmune hemolytic anemia", "drug": "fludarabine" } ]

Slow acetylators, who comprise roughly 50% of the South African population, are likely to develop clinical and biochemical features of phenytoin toxicity when this drug is given together with antituberculosis therapy.

[ { "ade": "phenytoin toxicity", "drug": "phenytoin" } ]

Drug induced polymyositis secondary to leuprolide acetate (Lupron) therapy for prostate carcinoma.

[ { "ade": "polymyositis", "drug": "Lupron" }, { "ade": "polymyositis", "drug": "leuprolide acetate" } ]

In each of the three reported patients, alteration of eyelid appearance with deepening of the lid sulcus was evident as the result of topical bimatoprost therapy.

[ { "ade": "deepening of the lid sulcus", "drug": "bimatoprost" }, { "ade": "alteration of eyelid appearance", "drug": "bimatoprost" } ]

CONCLUSIONS: For all patients with vancomycin-induced neutropenia, possible cross-reactivity of teicoplanin should be monitored.

[ { "ade": "neutropenia", "drug": "vancomycin" } ]

This is the first report of an adverse effect of fetal renal circulation by maternal ingestion of nimesulide.

[ { "ade": "adverse effect of fetal renal circulation", "drug": "nimesulide" } ]

This case report describes the development of asymptomatic visual field defects (VFDs) in a psychiatric patient with bipolar disorder receiving adjunctive tiagabine treatment.

[ { "ade": "VFDs", "drug": "tiagabine" }, { "ade": "visual field defects", "drug": "tiagabine" } ]

Unusual hypersensitivity to warfarin in a critically ill patient.

[ { "ade": "hypersensitivity", "drug": "warfarin" } ]

Cyclosporin side effects included hirsutism, hypertension, increased blood levels of urea and creatinine, and abnormalities in liver function tests.

[ { "ade": "abnormalities in liver function tests", "drug": "Cyclosporin" }, { "ade": "hypertension", "drug": "Cyclosporin" }, { "ade": "increased blood levels of urea and creatinine", "drug": "Cyclosporin" }, { "ade": "hirsutism", "drug": "Cyclosporin" } ]

Amiodarone was the third drug to induce AVT in this patient; she received 200 mg/day six days per week for six months.

[ { "ade": "AVT", "drug": "Amiodarone" } ]

Development of sarcoidosis during interferon alpha 2b and ribavirin combination therapy for chronic hepatitis C--a case report and review of the literature.

[ { "ade": "sarcoidosis", "drug": "ribavirin" }, { "ade": "sarcoidosis", "drug": "interferon alpha 2b" } ]

We present a case of significant over-anticoagulation temporally associated with a bout of protracted diarrhea in a patient on warfarin therapy.

[ { "ade": "diarrhea", "drug": "warfarin" }, { "ade": "over-anticoagulation", "drug": "warfarin" } ]

RESULTS: Both patients experienced a previously unreported side effect--falling backward--associated with bupropion use.

[ { "ade": "falling backward", "drug": "bupropion" } ]

Beneficial effect of low-dose mianserin on fluvoxamine-induced akathisia in an obsessive-compulsive patient.

[ { "ade": "akathisia", "drug": "fluvoxamine" } ]

A 21-year-old man with Tourette's syndrome, pedophilia, Asperger's syndrome, and multiple sclerosis experienced seizures after receiving therapy with interferon beta-1a.

[ { "ade": "seizures", "drug": "interferon beta-1a" } ]

Carboplatin hypersensitivity presenting as coronary vasospasm - a case report.

[ { "ade": "coronary vasospasm", "drug": "Carboplatin" } ]

Mesalamine may cause hypersensitivity pneumonitis in patients with Crohn's disease.

[ { "ade": "hypersensitivity pneumonitis", "drug": "Mesalamine" } ]

Pulmonary oedema after hexoprenaline administration in preterm labour.

[ { "ade": "Pulmonary oedema", "drug": "hexoprenaline" } ]

However, several case reports have suggested that clozapine could also cause TD.

[ { "ade": "TD", "drug": "clozapine" } ]

Levofloxacin-induced delirium with psychotic features.

[ { "ade": "delirium with psychotic features", "drug": "Levofloxacin" } ]

Argatroban for heparin-induced thrombocytopenia in hepato-renal failure and CVVHD.

[ { "ade": "thrombocytopenia", "drug": "heparin" } ]

We describe a patient who presented with bloody diarrhoea after 15 mg meloxicam daily for 10 days for osteoarthritis.

[ { "ade": "bloody diarrhoea", "drug": "meloxicam" } ]

BACKGROUND: Aphthous stomatitis, a common mucocutaneous disorder, is a well accepted complication of sirolimus therapy.

[ { "ade": "Aphthous stomatitis", "drug": "sirolimus" } ]

One should therefore be aware of possible extrapyramidal side effects with olanzapine that are reduced compared to classical neuroleptic drugs but not completely eliminated.

[ { "ade": "extrapyramidal side effects", "drug": "olanzapine" } ]

TREATMENT/OUTCOME: Standard anti-tuberculosis therapy was administered but was complicated by interaction with cyclosporine and drug-induced cholestasis.

[ { "ade": "cholestasis", "drug": "cyclosporine" } ]

A review of the literature revealed two other cases of hepatic angiosarcoma in patients after long-term cyclophosphamide treatment.

[ { "ade": "hepatic angiosarcoma", "drug": "cyclophosphamide" } ]

Persistent light reactivity from systemic quinine.

[ { "ade": "Persistent light reactivity", "drug": "quinine" } ]

Transient trazodone-induced hypomanic symptoms occurred in three depressed patients.

[ { "ade": "hypomanic symptoms", "drug": "trazodone" } ]

Nephrotic range pseudoproteinuria in a tolmetin-treated patient.

[ { "ade": "Nephrotic range pseudoproteinuria", "drug": "tolmetin" } ]

In this article, we describe a Japanese patient with severe interstitial pneumonia probably caused by sorafenib treatment for metastatic renal cell carcinoma.

[ { "ade": "severe interstitial pneumonia", "drug": "sorafenib" } ]

Chronic fentanyl application induces adrenocortical insufficiency.

[ { "ade": "adrenocortical insufficiency", "drug": "fentanyl" } ]

Fatal toxic epidermal necrolysis related to lamotrigine administration.

[ { "ade": "Fatal toxic epidermal necrolysis", "drug": "lamotrigine" } ]

Intrahepatic cholestasis and cutaneous bullae associated with glibenclamide therapy.

[ { "ade": "Intrahepatic cholestasis", "drug": "glibenclamide" }, { "ade": "cutaneous bullae", "drug": "glibenclamide" } ]

Hepatic damage after danazol treatment.

[ { "ade": "Hepatic damage", "drug": "danazol" } ]

We report an allogeneic bone marrow transplant recipient who developed CMV infection refractory to sequential therapy with ganciclovir, foscarnet, and cidofovir.

[ { "ade": "CMV infection", "drug": "foscarnet" }, { "ade": "CMV infection", "drug": "ganciclovir" }, { "ade": "CMV infection", "drug": "cidofovir" } ]

Intrathecal methotrexate-induced acute cerebellar syndrome.

[ { "ade": "acute cerebellar syndrome", "drug": "methotrexate" } ]

The potential role of propranolol in inducing central nervous system disturbances is emphasized, and the literature on the subject is reviewed.

[ { "ade": "central nervous system disturbances", "drug": "propranolol" } ]

This report highlights a case of drug-induced dysphagia in a patient receiving haloperidol for obsessive nocturnal thoughts and auditory disturbances.

[ { "ade": "dysphagia", "drug": "haloperidol" } ]

Multiple myeloma complicated by congestive heart failure following first administration of recombinant alpha-interferon.

[ { "ade": "congestive heart failure", "drug": "recombinant alpha-interferon" } ]

This represents the first report of nonconvulsive status epilepticus induced by ifosfamide.

[ { "ade": "nonconvulsive status epilepticus", "drug": "ifosfamide" } ]

A teenage girl with crescentic glomerulonephritis had antineutrophil cytoplasmic antibody (ANCA) detected after she had received propylthiouracil (PTU) for hyperthyroidism without cutaneous vasculitis.

[ { "ade": "antineutrophil cytoplasmic antibody", "drug": "PTU" }, { "ade": "antineutrophil cytoplasmic antibody", "drug": "propylthiouracil" } ]

Due to the severity of the rash, temozolomide was permanently discontinued.

[ { "ade": "rash", "drug": "temozolomide" } ]

After ruling out a hydrotelluric source of fluorine, the patient's fluorosis was linked to chronic use of niflumic acid, following the publication in 1978 of the 2 previously reported cases affected by this drug.

[ { "ade": "fluorosis", "drug": "niflumic acid" } ]

Ticlopidine-induced marrow aplasia treated with cyclosporine.

[ { "ade": "marrow aplasia", "drug": "Ticlopidine" } ]

Physicians should be aware of the risk of severe AIHA in CLL patients with a history of AIHA or positivation of the DAT during previous fludarabine administration, or in case of secondary fixation of complement to the red cell membrane occurring during fludarabine treatment.

[ { "ade": "positivation of the DAT", "drug": "fludarabine" }, { "ade": "AIHA", "drug": "fludarabine" } ]

Although isradipine has been associated with hepatocellular injury, there are no reports of fulminant liver failure with this agent, and our patient had been treated for >2 years without signs of toxicity.

[ { "ade": "hepatocellular injury", "drug": "isradipine" } ]

Severe corneal toxicity after topical fluoroquinolone therapy: report of two cases.

[ { "ade": "Severe corneal toxicity", "drug": "fluoroquinolone" } ]

A 57-year-old woman presented with a 3-week history of dysphagia for solids, 6 months after starting treatment with nifedipine.

[ { "ade": "dysphagia for solids", "drug": "nifedipine" } ]

RESULTS: Both cases presented here describe corneal ulcers that persisted and showed signs of worsening during weeks of frequent topical dosing with moxifloxacin.

[ { "ade": "corneal ulcers", "drug": "moxifloxacin" } ]

Recognition of a potential drug-induced Fanconi syndrome is important when managing pediatric oncology patients previously treated with ifosfamide.

[ { "ade": "Fanconi syndrome", "drug": "ifosfamide" } ]

The occurrence of a myocardial infarction is reported after chemotherapy containing etoposide, in a man with no risk factors for coronary heart disease.

[ { "ade": "myocardial infarction", "drug": "etoposide" } ]

CASE SUMMARIES: Two patients who received ifosfamide-containing chemotherapy developed NCSE.

[ { "ade": "NCSE", "drug": "ifosfamide" } ]

Even though only a few cases of this adverse event have been reported in the literature, severe docetaxel-induced pulmonary toxicity needs to be considered in the differential diagnosis when such patients present with respiratory symptoms.

[ { "ade": "pulmonary toxicity", "drug": "docetaxel" } ]

In the following case report, a patient developed acute interstitial nephritis with renal failure and exfoliative dermatitis following ampicillin therapy.

[ { "ade": "acute interstitial nephritis", "drug": "ampicillin" }, { "ade": "exfoliative dermatitis", "drug": "ampicillin" }, { "ade": "renal failure", "drug": "ampicillin" } ]

Interstitial pneumopathy and low-dosage amiodarone.

[ { "ade": "Interstitial pneumopathy", "drug": "amiodarone" } ]

OBJECTIVE: To report on the possible development of serotonin syndrome in a patient receiving clomipramine after clozapine was withdrawn from the treatment regimen.

[ { "ade": "serotonin syndrome", "drug": "clomipramine" }, { "ade": "serotonin syndrome", "drug": "clozapine" } ]

We report two cases of neutropenia following captopril use in cardiac patients with trisomy 21.

[ { "ade": "neutropenia", "drug": "captopril" } ]

When the disease recurred conventional amphotericin B was used again, but had to be stopped because of severe side effects.

[ { "ade": "severe side effects", "drug": "amphotericin B" } ]

One patient developed severe hyponatremia with serum Na+ of 108 mEq/L when hydrochlorothiazide was given to control hypertension.

[ { "ade": "severe hyponatremia", "drug": "hydrochlorothiazide" } ]

The mechanism of RTA induced by FK506 has not yet been clearly elucidated.

[ { "ade": "RTA", "drug": "FK506" } ]

We describe a patient with acute leukemia who developed Horner's syndrome and a severe demyelinating peripheral neuropathy leading to death after receiving high-dose cytosine arabinoside.

[ { "ade": "severe demyelinating peripheral neuropathy", "drug": "cytosine arabinoside" }, { "ade": "death", "drug": "cytosine arabinoside" }, { "ade": "Horner's syndrome", "drug": "cytosine arabinoside" } ]

Three male patients aged 78-83 years are presented, in whom severe hepatotoxic reactions emerged after CPA administration.

[ { "ade": "severe hepatotoxic reactions", "drug": "CPA" } ]

The literature is also reviewed for ARF associated with mannitol infusion in patients who received dialysis and those who did not receive dialysis; and the possible mechanism(s) of mannitol nephrotoxicity are discussed.

[ { "ade": "nephrotoxicity", "drug": "mannitol" }, { "ade": "ARF", "drug": "mannitol" } ]

Captopril is an angiotensin-converting enzyme (ACE) inhibitor and their cutaneous side-effects are documented, but little has been published concerning the usefulness of patch test when they occur.

[ { "ade": "cutaneous side-effects", "drug": "Captopril" } ]