mihirhirave/entity_extraction_ade_v2_with_validation

text stringlengths 22 455	relations listlengths 1 24
CASE REPORT: We report the case of a 58 year old patient who, after 2 days of treatment with roxithromycin and betamethasone, manifested acute pancreatitis.	[ { "ade": "acute pancreatitis", "drug": "betamethasone" }, { "ade": "acute pancreatitis", "drug": "roxithromycin" } ]
It is concluded that 'cerebral atrophy' on CT scans may represent an accumulative effect of ACTH and that ACTH should be given with the utmost discretion, and in as low a dose as possible.	[ { "ade": "cerebral atrophy", "drug": "ACTH" } ]
Lethal anuria complicating high dose ifosfamide chemotherapy in a breast cancer patient with an impaired renal function.	[ { "ade": "Lethal anuria", "drug": "ifosfamide" } ]
Thyroid dysfunction has been reported in patients with malignant disease treated with recombinant alpha interferon.	[ { "ade": "Thyroid dysfunction", "drug": "recombinant alpha interferon" } ]
This is the second report of acute lung injury and diffuse alveolar damage caused by mefloquine.	[ { "ade": "diffuse alveolar damage", "drug": "mefloquine" }, { "ade": "acute lung injury", "drug": "mefloquine" } ]
In contrast to chronic or subacute thyroiditis, Graves' disease rarely complicates IFN-alpha therapy for chronic viral C hepatitis.	[ { "ade": "subacute thyroiditis", "drug": "IFN-alpha" }, { "ade": "Graves' disease", "drug": "IFN-alpha" } ]
Myoclonus and seizures in a patient with parkinsonism: induction by levodopa and its confirmation on SEPs.	[ { "ade": "Myoclonus", "drug": "levodopa" }, { "ade": "seizures", "drug": "levodopa" } ]
Methotrexate-induced leukoencephalopathy is treatable with high-dose folinic acid: a case report and analysis of the literature.	[ { "ade": "leukoencephalopathy", "drug": "Methotrexate" } ]
An 11-year-old boy developed a severe enteropathy 2 years after initiation of clofazimine treatment for graft-versus-host disease.	[ { "ade": "severe enteropathy", "drug": "clofazimine" } ]
The latter form (Macrodantin) is reported to engender less gastrointestinal intolerance but it can produce the same adverse effects as the conventional form--liver damage, acute and chronic pulmonary reactions, peripheral neuropathy, blood dyscrasias and allergic reactions--and does so just as rapidly and floridly; one such case is reported here.	[ { "ade": "allergic reactions", "drug": "Macrodantin" }, { "ade": "peripheral neuropathy", "drug": "Macrodantin" }, { "ade": "acute and chronic pulmonary reactions", "drug": "Macrodantin" }, { "ade": "blood dyscrasias", "drug": "Macrodantin" }, { "ade": "liver damage", "drug": "Macrodantin" } ]
A case of SIADH associated with desipramine treatment in an elderly depressed woman is described.	[ { "ade": "SIADH", "drug": "desipramine" } ]
Clostridium difficile colitis associated with cisplatin-based chemotherapy in ovarian cancer patients.	[ { "ade": "Clostridium difficile colitis", "drug": "cisplatin" } ]
Because of serious side effects of an increase in the QT interval causing torsades de pointes, dofetilide must be initiated with close monitoring of the QT interval in an inpatient setting.	[ { "ade": "increase in the QT interval", "drug": "dofetilide" }, { "ade": "torsades de pointes", "drug": "dofetilide" } ]
This progressed to tracheal compression with stridor after he had taken some aspirin for relief of the neck pain.	[ { "ade": "tracheal compression", "drug": "aspirin" } ]
The uncomplicated long-term use of adequately-dosed AZA and stable non-toxic metabolite levels could not acknowledge TPMT deficiency as a primary cause of the leukopenia.	[ { "ade": "leukopenia", "drug": "AZA" } ]
A second episode of jaundice followed the intravaginal administration of a mixture of furazolidone and nifuroxime.	[ { "ade": "jaundice", "drug": "furazolidone" }, { "ade": "jaundice", "drug": "nifuroxime" } ]
Possible linkage of amprenavir with intracranial bleeding in an HIV-infected hemophiliac.	[ { "ade": "intracranial bleeding", "drug": "amprenavir" } ]
A patient with seropositive rheumatoid arthritis developed ascites while taking weekly doses of methotrexate (MTX).	[ { "ade": "ascites", "drug": "methotrexate" }, { "ade": "ascites", "drug": "MTX" } ]
Early ritonavir-induced maculopapular eruption.	[ { "ade": "maculopapular eruption", "drug": "ritonavir" } ]
We report a case of reversible encephalopathy syndrome in a 16-year-old girl with acute myelogenous leukemia (AML), who is undergoing during consolidation chemotherapy composed of BH-AC (N4-behenoyl-1-beta-D-arabinofuranosyl cytosine) and idarubicin.	[ { "ade": "encephalopathy syndrome", "drug": "BH-AC" }, { "ade": "encephalopathy syndrome", "drug": "idarubicin" } ]
The capacity of zuclopenthixol to induce priapism is thought to be due to its antagonist activity on alpha-adrenergic receptors.	[ { "ade": "priapism", "drug": "zuclopenthixol" } ]
Systemic corticosteroids in the phenytoin hypersensitivity syndrome.	[ { "ade": "phenytoin hypersensitivity syndrome", "drug": "phenytoin" } ]
There are no previous reports in the literature about the emergence of CML during treatment with hydroxyurea.	[ { "ade": "CML", "drug": "hydroxyurea" } ]
OBJECTIVE: To report two cases of fixed drug eruption induced by methylphenidate.	[ { "ade": "fixed drug eruption", "drug": "methylphenidate" } ]
It is suggested therefore that methotrexate be added to the list of agents capable of inducing diffuse interstitial pulmonary fibrosis.	[ { "ade": "diffuse interstitial pulmonary fibrosis", "drug": "methotrexate" } ]
Stupor and fast activity on electroencephalography in a child treated with valproate.	[ { "ade": "Stupor", "drug": "valproate" } ]
The harlequin color change and association with prostaglandin E1.	[ { "ade": "harlequin color change", "drug": "prostaglandin E1" } ]
A case of fluoxetine induced seizures, in a person with Down syndrome, is described.	[ { "ade": "seizures", "drug": "fluoxetine" } ]
Our review of 194 RA patients and 38 PsA patients receiving MTX has identified four RA patients and one PsA patient with MTX-induced pneumonitis, giving a prevalence of 2.1% and 0.03%, respectively.	[ { "ade": "pneumonitis", "drug": "MTX" } ]
Skin manifestations of a case of phenylbutazone-induced serum sickness-like reactions.	[ { "ade": "serum sickness-like reactions", "drug": "phenylbutazone" }, { "ade": "Skin manifestations", "drug": "phenylbutazone" } ]
Hemorrhagic cystitis is a significant toxic effect of cyclophosphamide therapy.	[ { "ade": "Hemorrhagic cystitis", "drug": "cyclophosphamide" } ]
Procainamide-induced incessant supraventricular tachycardia in the Wolff-Parkinson-White syndrome.	[ { "ade": "incessant supraventricular tachycardia", "drug": "Procainamide" } ]
Of particular interest in this patient is the fluctuation of the QT interval at a stable dose of methadone, suggesting that a single normal electrocardiogram (ECG) does not guarantee that the patient is not at risk of ventricular arrhythmias.	[ { "ade": "fluctuation of the QT interval", "drug": "methadone" } ]
Additive pulmonary toxicity with melphalan and busulfan therapy.	[ { "ade": "Additive pulmonary toxicity", "drug": "melphalan" }, { "ade": "Additive pulmonary toxicity", "drug": "busulfan" } ]
This paper reports a case of fatal perhexiline maleate liver injury.	[ { "ade": "fatal perhexiline maleate liver injury", "drug": "perhexiline maleate" } ]
Acute respiratory distress syndrome after rituximab infusion.	[ { "ade": "Acute respiratory distress syndrome", "drug": "rituximab" } ]
Reversible valproic acid-induced dementia: a case report.	[ { "ade": "dementia", "drug": "valproic acid" } ]
Minimal change nephrotic syndrome developing during postoperative interferon-beta therapy for malignant melanoma.	[ { "ade": "Minimal change nephrotic syndrome", "drug": "interferon-beta" } ]
Severe neurotoxicity with methyl G: CALGB experience.	[ { "ade": "Severe neurotoxicity", "drug": "methyl G: CALGB" } ]
Most cardiac surgical patients have had previous exposure to heparin for diagnostic or therapeutic interventions and hence have an increased susceptibility to developing heparin-induced thrombocytopenia (HIT) postoperatively.	[ { "ade": "thrombocytopenia", "drug": "heparin" } ]
This is the first report of non-convulsive status epilepticus provoked by tiagabine in adolescent patients.	[ { "ade": "non-convulsive status epilepticus", "drug": "tiagabine" } ]
Nifedipine may induce, or aggravate, pre-existing, gastro-oesophageal reflux.	[ { "ade": "gastro-oesophageal reflux", "drug": "Nifedipine" } ]
The successful development and implementation of this protocol will have impact on patients who have anaphylactic reactions to MTX but require this medication for specific diseases.	[ { "ade": "anaphylactic reactions", "drug": "MTX" } ]
Coadministration of antidepressant agents such as nefazodone, or any other drug that inhibits the CYP3A4 isoenzyme subfamily, should be anticipated to interfere with tacrolimus metabolism.	[ { "ade": "interfere with tacrolimus metabolism", "drug": "tacrolimus" }, { "ade": "interfere with tacrolimus metabolism", "drug": "nefazodone" } ]
Hepatitis following cimetidine administration.	[ { "ade": "Hepatitis", "drug": "cimetidine" } ]
Clinicians should include phenolphthalein in their list of possible causes of drug-induced TEN.	[ { "ade": "TEN", "drug": "phenolphthalein" } ]
A case of severe visual loss following a single dose of vincristine is described.	[ { "ade": "severe visual loss", "drug": "vincristine" } ]
In this report we described a case of juvenile idiopathic arthritis patient who developed thymic enlargement (true thymic hyperplasia), mediastinal lymphadenopathy and pleurisy associated with systemic symptoms under Etanercept treatment.	[ { "ade": "pleurisy", "drug": "Etanercept" }, { "ade": "thymic hyperplasia", "drug": "Etanercept" }, { "ade": "thymic enlargement", "drug": "Etanercept" }, { "ade": "mediastinal lymphadenopathy", "drug": "Etanercept" } ]
In the present paper, we describe two patients with active UC who developed a severe systemic CMV infection during a treatment with an oral microemulsion form of cyclosporine.	[ { "ade": "severe systemic CMV infection", "drug": "cyclosporine" } ]
High-grade atrioventricular block during dipyridamole stress testing.	[ { "ade": "High-grade atrioventricular block", "drug": "dipyridamole" } ]
Muzolimine-induced severe neuromyeloencephalopathy: report of seven cases.	[ { "ade": "severe neuromyeloencephalopathy", "drug": "Muzolimine" } ]
CASE PRESENTATION: Three cases of Leishmania infantum leishmaniasis in corticosteroid (CS)-treated patients are reported: an isolated lingual leishmaniasis in a farmer treated with CS for asthma, a severe visceral leishmaniasis associated with cutaneous lesions in a woman with myasthenia gravis, and a visceral involvement after cutaneous leishmaniasis in a man receiving CS.	[ { "ade": "cutaneous leishmaniasis", "drug": "CS" }, { "ade": "Leishmania infantum leishmaniasis", "drug": "CS" }, { "ade": "lingual leishmaniasis", "drug": "corticosteroid" }, { "ade": "Leishmania infantum leishmaniasis", "drug": "corticosteroid" }, { "ade": "lingual leishmaniasis", "drug": "CS" } ]
Ofloxacin: a probable cause of toxic epidermal necrolysis.	[ { "ade": "toxic epidermal necrolysis", "drug": "Ofloxacin" } ]
A brief review of reported cases of chloramphenicol hypersensitivity in the English-language literature, as well as possible alternative explanations in this case, are provided.	[ { "ade": "hypersensitivity", "drug": "chloramphenicol" } ]
We describe a premenopausal woman who, while having tamoxifen due to a diagnosis of in situ ductal carcinoma, developed endometriosis requiring surgery.	[ { "ade": "endometriosis", "drug": "tamoxifen" } ]
Anaphylactoid reaction to 50% solution of dextrose.	[ { "ade": "Anaphylactoid reaction", "drug": "dextrose" } ]
Physicians should be aware of the potential for developing a gemcitabine-induced radiation recall reaction resulting in hemodynamically significant pericardial effusion.	[ { "ade": "pericardial effusion", "drug": "gemcitabine" }, { "ade": "radiation recall reaction", "drug": "gemcitabine" } ]
Although the essential cause of PV is unclear, its onset has occasionally been associated with drug therapy, in particular penicillamine.	[ { "ade": "PV", "drug": "penicillamine" } ]
Severe rhabdomyolysis following massive ingestion of oolong tea: caffeine intoxication with coexisting hyponatremia.	[ { "ade": "rhabdomyolysis", "drug": "oolong tea" }, { "ade": "caffeine intoxication", "drug": "caffeine" }, { "ade": "rhabdomyolysis", "drug": "caffeine" }, { "ade": "caffeine intoxication", "drug": "oolong tea" } ]
Life-threatening cranial dystonia following trihexyphenidyl withdrawal.	[ { "ade": "cranial dystonia", "drug": "trihexyphenidyl" } ]
RESULTS: Replacing valproate with lamotrigine resulted in a decrease in serum testosterone concentrations in all 3 women.	[ { "ade": "serum testosterone", "drug": "valproate" } ]
We describe two cases of acute pancreatitis that occurred after long term mesalamine therapy for ulcerative colitis.	[ { "ade": "acute pancreatitis", "drug": "mesalamine" } ]
CONCLUSIONS: Clinicians should be aware of a risk of serotonin syndrome with serious extrapyramidal reactions in patients receiving sertraline or venlafaxine when metoclopramide is coadministered even in a single, conventional dose.	[ { "ade": "serotonin syndrome", "drug": "venlafaxine" }, { "ade": "extrapyramidal reactions", "drug": "sertraline" }, { "ade": "extrapyramidal reactions", "drug": "venlafaxine" }, { "ade": "extrapyramidal reactions", "drug": "metoclopramide" }, { "ade": "serotonin syndrome", "drug": "metoclopramide" }, { "ade": "serotonin syndrome", "drug": "sertraline" } ]
The case history confirms that gold treatment, even in the same patient, can give rise to a wide range of skin disturbances, which in many cases do not break out until long after the drug has been withdrawn.	[ { "ade": "skin disturbances", "drug": "gold" } ]
Severe steroid-induced glaucoma following intravitreal injection of triamcinolone acetonide.	[ { "ade": "glaucoma", "drug": "steroid" }, { "ade": "glaucoma", "drug": "triamcinolone acetonide" } ]
Within 6 months of pranlukast withdrawal, anemia resolved and urinary sediment and renal function normalized.	[ { "ade": "anemia", "drug": "pranlukast" } ]
Propylthiouracil-induced cutaneous vasculitis.	[ { "ade": "cutaneous vasculitis", "drug": "Propylthiouracil" } ]
Polymyositis after propylthiouracil treatment for hyperthyroidism.	[ { "ade": "Polymyositis", "drug": "propylthiouracil" } ]
OBJECTIVE: To report a case of severe chloroquine toxicity in the presence of high-grade chloroquine-resistant Plasmodium vivax.	[ { "ade": "severe chloroquine toxicity", "drug": "chloroquine" } ]
Amiodarone is well recognized as an anti-arrhythmic drug containing a high dose of iodine with considerable potential to cause thyroid dysfunction.	[ { "ade": "thyroid dysfunction", "drug": "Amiodarone" } ]
Fenclofenac-induced selective IgA deficiency in rheumatoid arthritis.	[ { "ade": "IgA deficiency", "drug": "Fenclofenac" } ]
Pharmacokinetic determinants of 6-mercaptopurine myelotoxicity and therapeutic failure in children with acute lymphoblastic leukemia.	[ { "ade": "myelotoxicity", "drug": "6-mercaptopurine" } ]
The course of delirium due to lithium intoxication.	[ { "ade": "delirium", "drug": "lithium" } ]
We report 2 cases of maculopapular eruption and fever in patients infected with human immunodeficiency virus (HIV) on the 2nd day of first administration of ritonavir, a protease inhibitor.	[ { "ade": "fever", "drug": "ritonavir" }, { "ade": "maculopapular eruption", "drug": "ritonavir" } ]
The purpose of this report is to document a new case of in utero CP exposure with multiple congenital anomalies and to establish an apparent CP embryopathy phenotype.	[ { "ade": "multiple congenital anomalies", "drug": "CP" }, { "ade": "embryopathy", "drug": "CP" } ]
It is increasingly recognized that dose adjustment of oral valacyclovir in renal failure is necessary to avoid neurotoxicity.	[ { "ade": "neurotoxicity", "drug": "valacyclovir" } ]
The present case is the first report of hypercalcemia induced by vitamin D3 ointment and thiazide simultaneously.	[ { "ade": "hypercalcemia", "drug": "thiazide" }, { "ade": "hypercalcemia", "drug": "vitamin D3" } ]
Two patients with extrapyramidal side effects after the use of fluphenazine decanoate were evaluated by means of IBZM-SPECT.	[ { "ade": "extrapyramidal side effects", "drug": "fluphenazine decanoate" } ]
A 71-year-old man with paroxysmal atrial fibrillation who had a previous anterior myocardial infarction exhibited granulocytopenia 8 days following the administration of oral sustained-release procainamide (750 mg/day).	[ { "ade": "granulocytopenia", "drug": "procainamide" } ]
A 55-year-old woman presented an episode of acute urticaria and labial angioedema 60 minutes after ingesting 500 mg of cloxacillin for a skin abscess.	[ { "ade": "labial angioedema", "drug": "cloxacillin" }, { "ade": "acute urticaria", "drug": "cloxacillin" } ]
A 34-year-old lady developed a constellation of dermatitis, fever, lymphadenopathy and hepatitis, beginning on the 17th day of a course of oral sulphasalazine for sero-negative rheumatoid arthritis.	[ { "ade": "lymphadenopathy", "drug": "sulphasalazine" }, { "ade": "fever", "drug": "sulphasalazine" }, { "ade": "hepatitis", "drug": "sulphasalazine" }, { "ade": "constellation of dermatitis", "drug": "sulphasalazine" } ]
The condition should be suspected in patients who develop unexplained abdominal pain or collapse following vasopressin treatment.	[ { "ade": "abdominal pain", "drug": "vasopressin" }, { "ade": "collapse", "drug": "vasopressin" } ]
These results indicate that lithium may cause biochemical hyperparathyroidism.	[ { "ade": "biochemical hyperparathyroidism", "drug": "lithium" } ]
Minocycline as a cause of drug-induced autoimmune hepatitis.	[ { "ade": "autoimmune hepatitis", "drug": "Minocycline" } ]
RESULTS: Three patients who developed symptoms of inflammatory bowel disease (IBD) during rofecoxib exposure are described along with pathology findings.	[ { "ade": "IBD", "drug": "rofecoxib" }, { "ade": "inflammatory bowel disease", "drug": "rofecoxib" } ]
The current report describes a man who was prescribed zonisamide for epilepsy and subsequently developed widespread skin rash, acute kidney injury, high-grade fever, eosinophilia, liver dysfunction, lymphadenopathy and an increase in antihuman herpesvirus-6 immunoglobulin G titer.	[ { "ade": "acute kidney injury", "drug": "zonisamide" }, { "ade": "high-grade fever", "drug": "zonisamide" }, { "ade": "eosinophilia", "drug": "zonisamide" }, { "ade": "liver dysfunction", "drug": "zonisamide" }, { "ade": "skin rash", "drug": "zonisamide" }, { "ade": "lymphadenopathy", "drug": "zonisamide" }, { "ade": "an increase in antihuman herpesvirus-6 immunoglobulin G titer", "drug": "zonisamide" } ]
Piloerection induced by replacing fluvoxamine with milnacipran.	[ { "ade": "Piloerection", "drug": "fluvoxamine" }, { "ade": "Piloerection", "drug": "milnacipran" } ]
This report describes a 13-year-old female with a right frontal high-grade glioma and complex partial seizures who developed localized purpura after 23 months of lamotrigine monotherapy.	[ { "ade": "localized purpura", "drug": "lamotrigine" } ]
Gold-induced aplastic anemia.	[ { "ade": "aplastic anemia", "drug": "Gold" } ]
Although his renal function recovered completely with high-dose leucovorin, hemodialysis, charcoal hemoperfusion, and carboxypeptidase G2, we present this case to emphasize that signs of renal toxicity may be present as early as 2 hours after the completion of a 4-hour MTX infusion, and to suggest that monitoring for MTX toxicity should perhaps begin within a few hours after the completion of 4-hour MTX infusion.	[ { "ade": "renal toxicity", "drug": "MTX" } ]
These evolutional changes in both proteinuria and glomerular histology suggest a close linkage between the M-CSF treatment and macrophage-related glomerular injury.	[ { "ade": "macrophage-related glomerular injury", "drug": "M-CSF" } ]
Uncontrolled headache induced by oxcarbazepine.	[ { "ade": "headache", "drug": "oxcarbazepine" } ]
Concomitant administration of lithium with olanzapine may place patients at risk for NMS.	[ { "ade": "NMS", "drug": "olanzapine" }, { "ade": "NMS", "drug": "lithium" } ]
OBJECTIVE: To report a case of linear immunoglobulin (Ig) A bullous dermatosis (LABD) induced by gemcitabine.	[ { "ade": "LABD", "drug": "gemcitabine" }, { "ade": "linear immunoglobulin (Ig) A bullous dermatosis", "drug": "gemcitabine" } ]
To our knowledge, this is the first case reported in the English literature of a generalized exanthem due to subcutaneous injection of enoxaparin.	[ { "ade": "generalized exanthem", "drug": "enoxaparin" } ]
A patient is described who developed a poorly differentiated sarcoma after cyclophosphamide was used to treat his rheumatoid arthritis.	[ { "ade": "sarcoma", "drug": "cyclophosphamide" } ]
Fortunately, a hypersensitivity reaction to one formulation of cyclosporine does not preclude use of a different formulation.	[ { "ade": "hypersensitivity reaction", "drug": "cyclosporine" } ]
Phantom limb pain as a manifestation of paclitaxel neurotoxicity.	[ { "ade": "Phantom limb pain", "drug": "paclitaxel" }, { "ade": "neurotoxicity", "drug": "paclitaxel" } ]
Temporary neurologic abnormalities were observed in one out of 23 patients undergoing chemotherapy with high-dose methotrexate (HD-MTX) for osteogenic sarcoma.	[ { "ade": "Temporary neurologic abnormalities", "drug": "methotrexate" } ]
After receiving 3 doses of ifosfamide/mesna, she was found to be unresponsive.	[ { "ade": "unresponsive", "drug": "ifosfamide" }, { "ade": "unresponsive", "drug": "mesna" } ]

CASE REPORT: We report the case of a 58 year old patient who, after 2 days of treatment with roxithromycin and betamethasone, manifested acute pancreatitis.

[ { "ade": "acute pancreatitis", "drug": "betamethasone" }, { "ade": "acute pancreatitis", "drug": "roxithromycin" } ]

It is concluded that 'cerebral atrophy' on CT scans may represent an accumulative effect of ACTH and that ACTH should be given with the utmost discretion, and in as low a dose as possible.

[ { "ade": "cerebral atrophy", "drug": "ACTH" } ]

Lethal anuria complicating high dose ifosfamide chemotherapy in a breast cancer patient with an impaired renal function.

[ { "ade": "Lethal anuria", "drug": "ifosfamide" } ]

Thyroid dysfunction has been reported in patients with malignant disease treated with recombinant alpha interferon.

[ { "ade": "Thyroid dysfunction", "drug": "recombinant alpha interferon" } ]

This is the second report of acute lung injury and diffuse alveolar damage caused by mefloquine.

[ { "ade": "diffuse alveolar damage", "drug": "mefloquine" }, { "ade": "acute lung injury", "drug": "mefloquine" } ]

In contrast to chronic or subacute thyroiditis, Graves' disease rarely complicates IFN-alpha therapy for chronic viral C hepatitis.

[ { "ade": "subacute thyroiditis", "drug": "IFN-alpha" }, { "ade": "Graves' disease", "drug": "IFN-alpha" } ]

Myoclonus and seizures in a patient with parkinsonism: induction by levodopa and its confirmation on SEPs.

[ { "ade": "Myoclonus", "drug": "levodopa" }, { "ade": "seizures", "drug": "levodopa" } ]

Methotrexate-induced leukoencephalopathy is treatable with high-dose folinic acid: a case report and analysis of the literature.

[ { "ade": "leukoencephalopathy", "drug": "Methotrexate" } ]

An 11-year-old boy developed a severe enteropathy 2 years after initiation of clofazimine treatment for graft-versus-host disease.

[ { "ade": "severe enteropathy", "drug": "clofazimine" } ]

The latter form (Macrodantin) is reported to engender less gastrointestinal intolerance but it can produce the same adverse effects as the conventional form--liver damage, acute and chronic pulmonary reactions, peripheral neuropathy, blood dyscrasias and allergic reactions--and does so just as rapidly and floridly; one such case is reported here.

[ { "ade": "allergic reactions", "drug": "Macrodantin" }, { "ade": "peripheral neuropathy", "drug": "Macrodantin" }, { "ade": "acute and chronic pulmonary reactions", "drug": "Macrodantin" }, { "ade": "blood dyscrasias", "drug": "Macrodantin" }, { "ade": "liver damage", "drug": "Macrodantin" } ]

A case of SIADH associated with desipramine treatment in an elderly depressed woman is described.

[ { "ade": "SIADH", "drug": "desipramine" } ]

Clostridium difficile colitis associated with cisplatin-based chemotherapy in ovarian cancer patients.

[ { "ade": "Clostridium difficile colitis", "drug": "cisplatin" } ]

Because of serious side effects of an increase in the QT interval causing torsades de pointes, dofetilide must be initiated with close monitoring of the QT interval in an inpatient setting.

[ { "ade": "increase in the QT interval", "drug": "dofetilide" }, { "ade": "torsades de pointes", "drug": "dofetilide" } ]

This progressed to tracheal compression with stridor after he had taken some aspirin for relief of the neck pain.

[ { "ade": "tracheal compression", "drug": "aspirin" } ]

The uncomplicated long-term use of adequately-dosed AZA and stable non-toxic metabolite levels could not acknowledge TPMT deficiency as a primary cause of the leukopenia.

[ { "ade": "leukopenia", "drug": "AZA" } ]

A second episode of jaundice followed the intravaginal administration of a mixture of furazolidone and nifuroxime.

[ { "ade": "jaundice", "drug": "furazolidone" }, { "ade": "jaundice", "drug": "nifuroxime" } ]

Possible linkage of amprenavir with intracranial bleeding in an HIV-infected hemophiliac.

[ { "ade": "intracranial bleeding", "drug": "amprenavir" } ]

A patient with seropositive rheumatoid arthritis developed ascites while taking weekly doses of methotrexate (MTX).

[ { "ade": "ascites", "drug": "methotrexate" }, { "ade": "ascites", "drug": "MTX" } ]

Early ritonavir-induced maculopapular eruption.

[ { "ade": "maculopapular eruption", "drug": "ritonavir" } ]

We report a case of reversible encephalopathy syndrome in a 16-year-old girl with acute myelogenous leukemia (AML), who is undergoing during consolidation chemotherapy composed of BH-AC (N4-behenoyl-1-beta-D-arabinofuranosyl cytosine) and idarubicin.

[ { "ade": "encephalopathy syndrome", "drug": "BH-AC" }, { "ade": "encephalopathy syndrome", "drug": "idarubicin" } ]

The capacity of zuclopenthixol to induce priapism is thought to be due to its antagonist activity on alpha-adrenergic receptors.

[ { "ade": "priapism", "drug": "zuclopenthixol" } ]

Systemic corticosteroids in the phenytoin hypersensitivity syndrome.

[ { "ade": "phenytoin hypersensitivity syndrome", "drug": "phenytoin" } ]

There are no previous reports in the literature about the emergence of CML during treatment with hydroxyurea.

[ { "ade": "CML", "drug": "hydroxyurea" } ]

OBJECTIVE: To report two cases of fixed drug eruption induced by methylphenidate.

[ { "ade": "fixed drug eruption", "drug": "methylphenidate" } ]

It is suggested therefore that methotrexate be added to the list of agents capable of inducing diffuse interstitial pulmonary fibrosis.

[ { "ade": "diffuse interstitial pulmonary fibrosis", "drug": "methotrexate" } ]

Stupor and fast activity on electroencephalography in a child treated with valproate.

[ { "ade": "Stupor", "drug": "valproate" } ]

The harlequin color change and association with prostaglandin E1.

[ { "ade": "harlequin color change", "drug": "prostaglandin E1" } ]

A case of fluoxetine induced seizures, in a person with Down syndrome, is described.

[ { "ade": "seizures", "drug": "fluoxetine" } ]

Our review of 194 RA patients and 38 PsA patients receiving MTX has identified four RA patients and one PsA patient with MTX-induced pneumonitis, giving a prevalence of 2.1% and 0.03%, respectively.

[ { "ade": "pneumonitis", "drug": "MTX" } ]

Skin manifestations of a case of phenylbutazone-induced serum sickness-like reactions.

[ { "ade": "serum sickness-like reactions", "drug": "phenylbutazone" }, { "ade": "Skin manifestations", "drug": "phenylbutazone" } ]

Hemorrhagic cystitis is a significant toxic effect of cyclophosphamide therapy.

[ { "ade": "Hemorrhagic cystitis", "drug": "cyclophosphamide" } ]

Procainamide-induced incessant supraventricular tachycardia in the Wolff-Parkinson-White syndrome.

[ { "ade": "incessant supraventricular tachycardia", "drug": "Procainamide" } ]

Of particular interest in this patient is the fluctuation of the QT interval at a stable dose of methadone, suggesting that a single normal electrocardiogram (ECG) does not guarantee that the patient is not at risk of ventricular arrhythmias.

[ { "ade": "fluctuation of the QT interval", "drug": "methadone" } ]

Additive pulmonary toxicity with melphalan and busulfan therapy.

[ { "ade": "Additive pulmonary toxicity", "drug": "melphalan" }, { "ade": "Additive pulmonary toxicity", "drug": "busulfan" } ]

This paper reports a case of fatal perhexiline maleate liver injury.

[ { "ade": "fatal perhexiline maleate liver injury", "drug": "perhexiline maleate" } ]

Acute respiratory distress syndrome after rituximab infusion.

[ { "ade": "Acute respiratory distress syndrome", "drug": "rituximab" } ]

Reversible valproic acid-induced dementia: a case report.

[ { "ade": "dementia", "drug": "valproic acid" } ]

Minimal change nephrotic syndrome developing during postoperative interferon-beta therapy for malignant melanoma.

[ { "ade": "Minimal change nephrotic syndrome", "drug": "interferon-beta" } ]

Severe neurotoxicity with methyl G: CALGB experience.

[ { "ade": "Severe neurotoxicity", "drug": "methyl G: CALGB" } ]

Most cardiac surgical patients have had previous exposure to heparin for diagnostic or therapeutic interventions and hence have an increased susceptibility to developing heparin-induced thrombocytopenia (HIT) postoperatively.

[ { "ade": "thrombocytopenia", "drug": "heparin" } ]

This is the first report of non-convulsive status epilepticus provoked by tiagabine in adolescent patients.

[ { "ade": "non-convulsive status epilepticus", "drug": "tiagabine" } ]

Nifedipine may induce, or aggravate, pre-existing, gastro-oesophageal reflux.

[ { "ade": "gastro-oesophageal reflux", "drug": "Nifedipine" } ]

The successful development and implementation of this protocol will have impact on patients who have anaphylactic reactions to MTX but require this medication for specific diseases.

[ { "ade": "anaphylactic reactions", "drug": "MTX" } ]

Coadministration of antidepressant agents such as nefazodone, or any other drug that inhibits the CYP3A4 isoenzyme subfamily, should be anticipated to interfere with tacrolimus metabolism.

[ { "ade": "interfere with tacrolimus metabolism", "drug": "tacrolimus" }, { "ade": "interfere with tacrolimus metabolism", "drug": "nefazodone" } ]

Hepatitis following cimetidine administration.

[ { "ade": "Hepatitis", "drug": "cimetidine" } ]

Clinicians should include phenolphthalein in their list of possible causes of drug-induced TEN.

[ { "ade": "TEN", "drug": "phenolphthalein" } ]

A case of severe visual loss following a single dose of vincristine is described.

[ { "ade": "severe visual loss", "drug": "vincristine" } ]

In this report we described a case of juvenile idiopathic arthritis patient who developed thymic enlargement (true thymic hyperplasia), mediastinal lymphadenopathy and pleurisy associated with systemic symptoms under Etanercept treatment.

[ { "ade": "pleurisy", "drug": "Etanercept" }, { "ade": "thymic hyperplasia", "drug": "Etanercept" }, { "ade": "thymic enlargement", "drug": "Etanercept" }, { "ade": "mediastinal lymphadenopathy", "drug": "Etanercept" } ]

In the present paper, we describe two patients with active UC who developed a severe systemic CMV infection during a treatment with an oral microemulsion form of cyclosporine.

[ { "ade": "severe systemic CMV infection", "drug": "cyclosporine" } ]

High-grade atrioventricular block during dipyridamole stress testing.

[ { "ade": "High-grade atrioventricular block", "drug": "dipyridamole" } ]

Muzolimine-induced severe neuromyeloencephalopathy: report of seven cases.

[ { "ade": "severe neuromyeloencephalopathy", "drug": "Muzolimine" } ]

CASE PRESENTATION: Three cases of Leishmania infantum leishmaniasis in corticosteroid (CS)-treated patients are reported: an isolated lingual leishmaniasis in a farmer treated with CS for asthma, a severe visceral leishmaniasis associated with cutaneous lesions in a woman with myasthenia gravis, and a visceral involvement after cutaneous leishmaniasis in a man receiving CS.

[ { "ade": "cutaneous leishmaniasis", "drug": "CS" }, { "ade": "Leishmania infantum leishmaniasis", "drug": "CS" }, { "ade": "lingual leishmaniasis", "drug": "corticosteroid" }, { "ade": "Leishmania infantum leishmaniasis", "drug": "corticosteroid" }, { "ade": "lingual leishmaniasis", "drug": "CS" } ]

Ofloxacin: a probable cause of toxic epidermal necrolysis.

[ { "ade": "toxic epidermal necrolysis", "drug": "Ofloxacin" } ]

A brief review of reported cases of chloramphenicol hypersensitivity in the English-language literature, as well as possible alternative explanations in this case, are provided.

[ { "ade": "hypersensitivity", "drug": "chloramphenicol" } ]

We describe a premenopausal woman who, while having tamoxifen due to a diagnosis of in situ ductal carcinoma, developed endometriosis requiring surgery.

[ { "ade": "endometriosis", "drug": "tamoxifen" } ]

Anaphylactoid reaction to 50% solution of dextrose.

[ { "ade": "Anaphylactoid reaction", "drug": "dextrose" } ]

Physicians should be aware of the potential for developing a gemcitabine-induced radiation recall reaction resulting in hemodynamically significant pericardial effusion.

[ { "ade": "pericardial effusion", "drug": "gemcitabine" }, { "ade": "radiation recall reaction", "drug": "gemcitabine" } ]

Although the essential cause of PV is unclear, its onset has occasionally been associated with drug therapy, in particular penicillamine.

[ { "ade": "PV", "drug": "penicillamine" } ]

Severe rhabdomyolysis following massive ingestion of oolong tea: caffeine intoxication with coexisting hyponatremia.

[ { "ade": "rhabdomyolysis", "drug": "oolong tea" }, { "ade": "caffeine intoxication", "drug": "caffeine" }, { "ade": "rhabdomyolysis", "drug": "caffeine" }, { "ade": "caffeine intoxication", "drug": "oolong tea" } ]

Life-threatening cranial dystonia following trihexyphenidyl withdrawal.

[ { "ade": "cranial dystonia", "drug": "trihexyphenidyl" } ]

RESULTS: Replacing valproate with lamotrigine resulted in a decrease in serum testosterone concentrations in all 3 women.

[ { "ade": "serum testosterone", "drug": "valproate" } ]

We describe two cases of acute pancreatitis that occurred after long term mesalamine therapy for ulcerative colitis.

[ { "ade": "acute pancreatitis", "drug": "mesalamine" } ]

CONCLUSIONS: Clinicians should be aware of a risk of serotonin syndrome with serious extrapyramidal reactions in patients receiving sertraline or venlafaxine when metoclopramide is coadministered even in a single, conventional dose.

[ { "ade": "serotonin syndrome", "drug": "venlafaxine" }, { "ade": "extrapyramidal reactions", "drug": "sertraline" }, { "ade": "extrapyramidal reactions", "drug": "venlafaxine" }, { "ade": "extrapyramidal reactions", "drug": "metoclopramide" }, { "ade": "serotonin syndrome", "drug": "metoclopramide" }, { "ade": "serotonin syndrome", "drug": "sertraline" } ]

The case history confirms that gold treatment, even in the same patient, can give rise to a wide range of skin disturbances, which in many cases do not break out until long after the drug has been withdrawn.

[ { "ade": "skin disturbances", "drug": "gold" } ]

Severe steroid-induced glaucoma following intravitreal injection of triamcinolone acetonide.

[ { "ade": "glaucoma", "drug": "steroid" }, { "ade": "glaucoma", "drug": "triamcinolone acetonide" } ]

Within 6 months of pranlukast withdrawal, anemia resolved and urinary sediment and renal function normalized.

[ { "ade": "anemia", "drug": "pranlukast" } ]

Propylthiouracil-induced cutaneous vasculitis.

[ { "ade": "cutaneous vasculitis", "drug": "Propylthiouracil" } ]

Polymyositis after propylthiouracil treatment for hyperthyroidism.

[ { "ade": "Polymyositis", "drug": "propylthiouracil" } ]

OBJECTIVE: To report a case of severe chloroquine toxicity in the presence of high-grade chloroquine-resistant Plasmodium vivax.

[ { "ade": "severe chloroquine toxicity", "drug": "chloroquine" } ]

Amiodarone is well recognized as an anti-arrhythmic drug containing a high dose of iodine with considerable potential to cause thyroid dysfunction.

[ { "ade": "thyroid dysfunction", "drug": "Amiodarone" } ]

Fenclofenac-induced selective IgA deficiency in rheumatoid arthritis.

[ { "ade": "IgA deficiency", "drug": "Fenclofenac" } ]

Pharmacokinetic determinants of 6-mercaptopurine myelotoxicity and therapeutic failure in children with acute lymphoblastic leukemia.

[ { "ade": "myelotoxicity", "drug": "6-mercaptopurine" } ]

The course of delirium due to lithium intoxication.

[ { "ade": "delirium", "drug": "lithium" } ]

We report 2 cases of maculopapular eruption and fever in patients infected with human immunodeficiency virus (HIV) on the 2nd day of first administration of ritonavir, a protease inhibitor.

[ { "ade": "fever", "drug": "ritonavir" }, { "ade": "maculopapular eruption", "drug": "ritonavir" } ]

The purpose of this report is to document a new case of in utero CP exposure with multiple congenital anomalies and to establish an apparent CP embryopathy phenotype.

[ { "ade": "multiple congenital anomalies", "drug": "CP" }, { "ade": "embryopathy", "drug": "CP" } ]

It is increasingly recognized that dose adjustment of oral valacyclovir in renal failure is necessary to avoid neurotoxicity.

[ { "ade": "neurotoxicity", "drug": "valacyclovir" } ]

The present case is the first report of hypercalcemia induced by vitamin D3 ointment and thiazide simultaneously.

[ { "ade": "hypercalcemia", "drug": "thiazide" }, { "ade": "hypercalcemia", "drug": "vitamin D3" } ]

Two patients with extrapyramidal side effects after the use of fluphenazine decanoate were evaluated by means of IBZM-SPECT.

[ { "ade": "extrapyramidal side effects", "drug": "fluphenazine decanoate" } ]

A 71-year-old man with paroxysmal atrial fibrillation who had a previous anterior myocardial infarction exhibited granulocytopenia 8 days following the administration of oral sustained-release procainamide (750 mg/day).

[ { "ade": "granulocytopenia", "drug": "procainamide" } ]

A 55-year-old woman presented an episode of acute urticaria and labial angioedema 60 minutes after ingesting 500 mg of cloxacillin for a skin abscess.

[ { "ade": "labial angioedema", "drug": "cloxacillin" }, { "ade": "acute urticaria", "drug": "cloxacillin" } ]

A 34-year-old lady developed a constellation of dermatitis, fever, lymphadenopathy and hepatitis, beginning on the 17th day of a course of oral sulphasalazine for sero-negative rheumatoid arthritis.

[ { "ade": "lymphadenopathy", "drug": "sulphasalazine" }, { "ade": "fever", "drug": "sulphasalazine" }, { "ade": "hepatitis", "drug": "sulphasalazine" }, { "ade": "constellation of dermatitis", "drug": "sulphasalazine" } ]

The condition should be suspected in patients who develop unexplained abdominal pain or collapse following vasopressin treatment.

[ { "ade": "abdominal pain", "drug": "vasopressin" }, { "ade": "collapse", "drug": "vasopressin" } ]

These results indicate that lithium may cause biochemical hyperparathyroidism.

[ { "ade": "biochemical hyperparathyroidism", "drug": "lithium" } ]

Minocycline as a cause of drug-induced autoimmune hepatitis.

[ { "ade": "autoimmune hepatitis", "drug": "Minocycline" } ]

RESULTS: Three patients who developed symptoms of inflammatory bowel disease (IBD) during rofecoxib exposure are described along with pathology findings.

[ { "ade": "IBD", "drug": "rofecoxib" }, { "ade": "inflammatory bowel disease", "drug": "rofecoxib" } ]

The current report describes a man who was prescribed zonisamide for epilepsy and subsequently developed widespread skin rash, acute kidney injury, high-grade fever, eosinophilia, liver dysfunction, lymphadenopathy and an increase in antihuman herpesvirus-6 immunoglobulin G titer.

[ { "ade": "acute kidney injury", "drug": "zonisamide" }, { "ade": "high-grade fever", "drug": "zonisamide" }, { "ade": "eosinophilia", "drug": "zonisamide" }, { "ade": "liver dysfunction", "drug": "zonisamide" }, { "ade": "skin rash", "drug": "zonisamide" }, { "ade": "lymphadenopathy", "drug": "zonisamide" }, { "ade": "an increase in antihuman herpesvirus-6 immunoglobulin G titer", "drug": "zonisamide" } ]

Piloerection induced by replacing fluvoxamine with milnacipran.

[ { "ade": "Piloerection", "drug": "fluvoxamine" }, { "ade": "Piloerection", "drug": "milnacipran" } ]

This report describes a 13-year-old female with a right frontal high-grade glioma and complex partial seizures who developed localized purpura after 23 months of lamotrigine monotherapy.

[ { "ade": "localized purpura", "drug": "lamotrigine" } ]

Gold-induced aplastic anemia.

[ { "ade": "aplastic anemia", "drug": "Gold" } ]

Although his renal function recovered completely with high-dose leucovorin, hemodialysis, charcoal hemoperfusion, and carboxypeptidase G2, we present this case to emphasize that signs of renal toxicity may be present as early as 2 hours after the completion of a 4-hour MTX infusion, and to suggest that monitoring for MTX toxicity should perhaps begin within a few hours after the completion of 4-hour MTX infusion.

[ { "ade": "renal toxicity", "drug": "MTX" } ]

These evolutional changes in both proteinuria and glomerular histology suggest a close linkage between the M-CSF treatment and macrophage-related glomerular injury.

[ { "ade": "macrophage-related glomerular injury", "drug": "M-CSF" } ]

Uncontrolled headache induced by oxcarbazepine.

[ { "ade": "headache", "drug": "oxcarbazepine" } ]

Concomitant administration of lithium with olanzapine may place patients at risk for NMS.

[ { "ade": "NMS", "drug": "olanzapine" }, { "ade": "NMS", "drug": "lithium" } ]

OBJECTIVE: To report a case of linear immunoglobulin (Ig) A bullous dermatosis (LABD) induced by gemcitabine.

[ { "ade": "LABD", "drug": "gemcitabine" }, { "ade": "linear immunoglobulin (Ig) A bullous dermatosis", "drug": "gemcitabine" } ]

To our knowledge, this is the first case reported in the English literature of a generalized exanthem due to subcutaneous injection of enoxaparin.

[ { "ade": "generalized exanthem", "drug": "enoxaparin" } ]

A patient is described who developed a poorly differentiated sarcoma after cyclophosphamide was used to treat his rheumatoid arthritis.

[ { "ade": "sarcoma", "drug": "cyclophosphamide" } ]

Fortunately, a hypersensitivity reaction to one formulation of cyclosporine does not preclude use of a different formulation.

[ { "ade": "hypersensitivity reaction", "drug": "cyclosporine" } ]

Phantom limb pain as a manifestation of paclitaxel neurotoxicity.

[ { "ade": "Phantom limb pain", "drug": "paclitaxel" }, { "ade": "neurotoxicity", "drug": "paclitaxel" } ]

Temporary neurologic abnormalities were observed in one out of 23 patients undergoing chemotherapy with high-dose methotrexate (HD-MTX) for osteogenic sarcoma.

[ { "ade": "Temporary neurologic abnormalities", "drug": "methotrexate" } ]

After receiving 3 doses of ifosfamide/mesna, she was found to be unresponsive.

[ { "ade": "unresponsive", "drug": "ifosfamide" }, { "ade": "unresponsive", "drug": "mesna" } ]