mihirhirave/entity_extraction_ade_v2_with_validation

text stringlengths 22 455	relations listlengths 1 24
We report a patient with advanced colonic carcinoma who was treated with concomitant chemoirradiation with oxaliplatin and developed a peculiar dermnatitis in the irradiated field after being exposed to subsequent chemotherapy with oxaliplatin.	[ { "ade": "dermnatitis", "drug": "oxaliplatin" } ]
Naproxen is a commonly used nonsteroidal anti-inflammatory drug (NSAID) whose side effects include tinnitus and transient hearing loss.	[ { "ade": "transient hearing loss", "drug": "Naproxen" }, { "ade": "tinnitus", "drug": "Naproxen" } ]
Moreover, these findings suggest that the incidence of BOOP following rituximab therapy may be higher than has been previously appreciated.	[ { "ade": "BOOP", "drug": "rituximab" } ]
Interference with the cortisol axis by the microtubule antagonist, CPH82.	[ { "ade": "Interference with the cortisol axis", "drug": "CPH82" } ]
We report three cases of severe hepatotoxicity related to benzarone, a benzofuran derivative.	[ { "ade": "severe hepatotoxicity", "drug": "benzarone" } ]
Ovarian endometrioid adenocarcinoma arising from an endometriotic cyst in a postmenopausal woman under tamoxifen therapy for breast cancer: a case report.	[ { "ade": "Ovarian endometrioid adenocarcinoma", "drug": "tamoxifen" } ]
Leflunomide-induced toxic epidermal necrolysis in a patient with rheumatoid arthritis.	[ { "ade": "toxic epidermal necrolysis", "drug": "Leflunomide" } ]
Clinicians should be cognizant of this possibility and consider a diagnosis of HDAs in patients with ongoing thrombosis who are receiving heparin therapy.	[ { "ade": "thrombosis", "drug": "heparin" } ]
Clostridium difficile toxin-induced colitis after use of clindamycin phosphate vaginal cream.	[ { "ade": "Clostridium difficile toxin-induced colitis", "drug": "clindamycin phosphate" } ]
They seemed to involve multiple aetiological factors, such as autoimmune thyroid disease, the toxic and immunomodulatory roles of lithium and perhaps genetic and dietary factors.	[ { "ade": "toxic and immunomodulatory roles", "drug": "lithium" } ]
Reversible corneal keratinization following trabeculectomy and treatment with 5-fluorouracil.	[ { "ade": "Reversible corneal keratinization", "drug": "5-fluorouracil" } ]
Marked QT prolongation and torsades de pointes secondary to acute ischemia in an elderly man taking dofetilide for atrial fibrillation: a cautionary tale.	[ { "ade": "Marked QT prolongation", "drug": "dofetilide" }, { "ade": "acute ischemia", "drug": "dofetilide" }, { "ade": "torsades de pointes", "drug": "dofetilide" } ]
Methadone-induced myoclonus in advanced cancer.	[ { "ade": "myoclonus", "drug": "Methadone" } ]
Dapsone-induced erythroderma with Beau's lines.	[ { "ade": "erythroderma", "drug": "Dapsone" } ]
Near fatal acute colchicine intoxication in a child.	[ { "ade": "Near fatal", "drug": "colchicine" }, { "ade": "colchicine intoxication", "drug": "colchicine" } ]
Acute nitrite toxicity results from industrial exposure, accidental ingestion (e.g., abuse of organic nitrites as an aphrodisiac, especially in the male homosexual population), and suicidal ingestion.	[ { "ade": "nitrite toxicity", "drug": "nitrite" } ]
We conclude that the presence of this metabolic defect combined with topical 5-FU (a drug demonstrating a narrow therapeutic index) results in the unusual presentation of life-threatening toxicity after treatment with a topical drug.	[ { "ade": "life-threatening toxicity", "drug": "5-FU" } ]
Sirolimus-associated hepatotoxicity in the kidney graft recipient.	[ { "ade": "hepatotoxicity", "drug": "Sirolimus" } ]
Marked sinus tachycardia resulting from the synergistic effects of marijuana and nortriptyline.	[ { "ade": "sinus tachycardia", "drug": "nortriptyline" } ]
However, the amount of prednisone required to maintain normotension resulted in Cushingoid features and has been discontinued.	[ { "ade": "Cushingoid features", "drug": "prednisone" } ]
Carbamazepine toxicity following Oxybutynin and Dantrolene administration: a case report.	[ { "ade": "Carbamazepine toxicity", "drug": "Dantrolene" }, { "ade": "Carbamazepine toxicity", "drug": "Oxybutynin" }, { "ade": "Carbamazepine toxicity", "drug": "Carbamazepine" } ]
PURPOSE: To describe transient structured visual hallucinations in a patient with vascular age-related macular degeneration (AMD), following an intravitreal Avastin-injection.	[ { "ade": "transient structured visual hallucinations", "drug": "Avastin" } ]
The aim of this paper is to report the case of rosaceiform eruption induced by erlotinib in an 81-year-old-man and to discuss the pathogenetic role of Demodex folliculorum mites, found in the present patient, using skin scraping.	[ { "ade": "rosaceiform eruption", "drug": "erlotinib" } ]
A 25-year-old woman sought medical attention because of iliocaval manifestations of retroperitoneal fibrosis while she was taking methysergide.	[ { "ade": "retroperitoneal fibrosis", "drug": "methysergide" } ]
Alveolar-interstitial pneumopathy after gold-salts compounds administration, requiring mechanical ventilation.	[ { "ade": "Alveolar-interstitial pneumopathy", "drug": "gold" } ]
Intraventricular nafcillin-induced seizures in a neonate.	[ { "ade": "seizures", "drug": "nafcillin" } ]
The authors describe valproate-induced hyperammonemia and mental status changes in an 88-year-old man, the first known reported case in an elderly patient.	[ { "ade": "hyperammonemia", "drug": "valproate" }, { "ade": "mental status changes", "drug": "valproate" } ]
The possible effects of tamoxifen upon the uterus are discussed in this article, in view of reports of tamoxifen associated with endometrial carcinoma and endometriosis.	[ { "ade": "endometriosis", "drug": "tamoxifen" }, { "ade": "endometrial carcinoma", "drug": "tamoxifen" } ]
The polycystic changes disappeared from the ovaries in 2 of the women after valproate therapy was discontinued, and the 2 women who had gained weight and developed amenorrhea while being treated with valproate lost weight and resumed menstruating after the change in medication.	[ { "ade": "amenorrhea", "drug": "valproate" }, { "ade": "gained weight", "drug": "valproate" }, { "ade": "polycystic changes", "drug": "valproate" } ]
A 2-year-old mentally retarded boy with frontal lobe epilepsy presented with an episode that resembled heat stroke during the administration of zonisamide.	[ { "ade": "heat stroke", "drug": "zonisamide" } ]
CASE REPORT: We report a case of acute severe hepatitis resulting from erlotinib monotherapy in a patient with locally advanced pancreatic cancer.	[ { "ade": "acute severe hepatitis", "drug": "erlotinib" } ]
According to the Naranjo et al. adverse-reaction probability scale, enoxaparin was the probable cause of hepatotoxicity in this patient.	[ { "ade": "hepatotoxicity", "drug": "enoxaparin" } ]
However, a large case-control study included three cases of either Stevens-Johnson syndrome or toxic epidermal necrolysis associated with ofloxacin use, but no details of the cases were given.	[ { "ade": "toxic epidermal necrolysis", "drug": "ofloxacin" }, { "ade": "Stevens-Johnson syndrome", "drug": "ofloxacin" } ]
We describe a patient with rheumatoid arthritis treated with gold salts, who developed bilateral interstitial pulmonary abnormalities and showed a dramatic response on corticosteroid therapy.	[ { "ade": "bilateral interstitial pulmonary abnormalities", "drug": "gold" } ]
In this article lithium is not discussed, although there are a number of concerns about lithium's potential teratogenicity, and it has been implicated in Epstein's anomaly, a congenital heart defect among infants born to women taking lithium; as with other medications, however, the data have specific limitations.	[ { "ade": "teratogenicity", "drug": "lithium" }, { "ade": "Epstein's anomaly", "drug": "lithium" } ]
In a female with acute lymphoblastic leukemia, inadvertent doxorubicin administration intrathecally caused severe, life-threatening, acute encephalopathy with high-pressure hydrocephalus.	[ { "ade": "high-pressure hydrocephalus", "drug": "doxorubicin" }, { "ade": "acute encephalopathy", "drug": "doxorubicin" } ]
Possible mechanisms by which clonidine decreases spasticity are described, probable mechanisms of induced bradycardia are reviewed, and specific treatment recommendations for the use of clonidine in spinal cord injured patients are presented.	[ { "ade": "bradycardia", "drug": "clonidine" } ]
Secondary acute myeloid leukemia after etoposide therapy for haemophagocytic lymphohistiocytosis.	[ { "ade": "acute myeloid leukemia", "drug": "etoposide" } ]
The mean time from starting MMF to the development of neutropenia was 4 months.	[ { "ade": "neutropenia", "drug": "MMF" } ]
However, 1 eye had vitreous hemorrhage after repeated injections of tPA.	[ { "ade": "vitreous hemorrhage", "drug": "tPA" } ]
These cases demonstrate that CBZ can induce simple motor tics in children.	[ { "ade": "motor tics", "drug": "CBZ" } ]
One patient was an 80-year-old woman who was admitted for Staphylococcus aureus knee arthritis after several intraarticular injections of sodium hyaluronate and corticosteroids.	[ { "ade": "Staphylococcus aureus knee arthritis", "drug": "sodium hyaluronate" }, { "ade": "Staphylococcus aureus knee arthritis", "drug": "corticosteroids" } ]
Fracture of the femoral neck occurred in one patient during PSL therapy, although the relationship between the fracture and PSL therapy was uncertain.	[ { "ade": "Fracture of the femoral neck", "drug": "PSL" } ]
Cutaneous ulceration: an unusual complication of intravenous pentamidine therapy.	[ { "ade": "Cutaneous ulceration", "drug": "pentamidine" } ]
Pancytopenia associated with 5-aminosalicylic acid use in a patient with Crohn's disease.	[ { "ade": "Pancytopenia", "drug": "5-aminosalicylic acid" } ]
A 54-year-old man, treated with amiodarone, developed thyrotoxicosis.	[ { "ade": "thyrotoxicosis", "drug": "amiodarone" } ]
Fatal pulmonary fibrosis following 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) therapy.	[ { "ade": "Fatal pulmonary fibrosis", "drug": "BCNU" }, { "ade": "Fatal pulmonary fibrosis", "drug": "1,3-bis(2-chloroethyl)-1-nitrosourea" } ]
A 57-year-old man developed morphea while taking bromocriptine.	[ { "ade": "morphea", "drug": "bromocriptine" } ]
Carboplatin hypersensitivity induced by low-dose paclitaxel/carboplatin in multiple platinum-treated patients with recurrent ovarian cancer.	[ { "ade": "hypersensitivity", "drug": "Carboplatin" }, { "ade": "hypersensitivity", "drug": "carboplatin" }, { "ade": "hypersensitivity", "drug": "paclitaxel" } ]
STUDY DESIGN: Case report of a 31-year-old woman who presented with toxic myelopathy due to intrathecal administration of doxorubicin.	[ { "ade": "toxic myelopathy", "drug": "doxorubicin" } ]
Withdrawal of Depakote resulted in resolution of the effusion.	[ { "ade": "effusion", "drug": "Depakote" } ]
Severe C. difficile colitis occurred in 2 patients (6.1%) after receiving cisplatin-based combination chemotherapy for ovarian malignancies.	[ { "ade": "C. difficile colitis", "drug": "cisplatin" } ]
Patients with vitamin B12 deficiency are exceedingly sensitive to neurologic deterioration following nitrous oxide anesthesia.	[ { "ade": "neurologic deterioration", "drug": "nitrous oxide" } ]
Cimetidine-induced fever.	[ { "ade": "fever", "drug": "Cimetidine" } ]
Regardless of a negative history of asthma, therefore, life-threatening bronchospasm must be considered a possible complication of propranolol therapy.	[ { "ade": "bronchospasm", "drug": "propranolol" } ]
CONCLUSIONS: LTG overdose may result in a severe but reversible encephalopathy, a previously undescribed phenomenon.	[ { "ade": "encephalopathy", "drug": "LTG" } ]
This eruption emerged after 1 month of therapy with salsalate, persisted for as long as salsalate was administered, and cleared within 3 weeks of discontinuing the medication.	[ { "ade": "eruption", "drug": "salsalate" } ]
We report the case histories of two patients with histologically confirmed adenocarcinoma of the prostate, both of whom had been treated with steroidal anti-androgen therapy in the form of cyproterone acetate prior to radical or palliative pelvic irradiation, and who subsequently developed femoral head avascular necrosis.	[ { "ade": "femoral head avascular necrosis", "drug": "cyproterone acetate" } ]
Heparin-induced hyperkalemia.	[ { "ade": "hyperkalemia", "drug": "Heparin" } ]
Patients with lymphoblastic lymphoma who had treatment with L-asparaginase and steroid are predisposed to the development of cortical venous thrombosis and may have this syndrome in addition to a dural puncture headache.	[ { "ade": "cortical venous thrombosis", "drug": "L-asparaginase" }, { "ade": "dural puncture headache", "drug": "L-asparaginase" } ]
A rare case of advanced ovarian carcinoma who developed difficulty walking 25 days after treatment with weekly paclitaxel.	[ { "ade": "difficulty walking", "drug": "paclitaxel" } ]
The photosensitivity is still present 3 years after the withdrawal of quinine.	[ { "ade": "photosensitivity", "drug": "quinine" } ]
Symptomatic hypoglycemia secondary to a glipizide-trimethoprim/sulfamethoxazole drug interaction.	[ { "ade": "Symptomatic hypoglycemia", "drug": "sulfamethoxazole" }, { "ade": "Symptomatic hypoglycemia", "drug": "glipizide" }, { "ade": "Symptomatic hypoglycemia", "drug": "trimethoprim" } ]
Glomerulonephritis in procainamide induced lupus erythematosus: report of a case and review of the literature.	[ { "ade": "Glomerulonephritis", "drug": "procainamide" }, { "ade": "lupus erythematosus", "drug": "procainamide" } ]
Aggressive endometrial carcinoma in a breast cancer patient treated with tamoxifen with normal transvaginal ultrasonography.	[ { "ade": "Aggressive endometrial carcinoma", "drug": "tamoxifen" } ]
The risk of cardiac decompensation in infants with supraventricular tachycardia and congestive cardiac failure should be kept in mind prior to administration of verapamil.	[ { "ade": "cardiac decompensation", "drug": "verapamil" } ]
Interferon-alpha-induced hyperthyroidism: a three-stage evolution from silent thyroiditis towards Graves' disease.	[ { "ade": "hyperthyroidism", "drug": "Interferon-alpha" } ]
Relapse in the external auditory canal of acute promyelocytic leukemia after treatment with all-trans retinoic acid.	[ { "ade": "Relapse in the external auditory canal of acute promyelocytic leukemia", "drug": "all-trans retinoic acid" } ]
Several hypersensitivity reactions to cloxacillin have been reported, although IgE-mediated allergic reactions to the drug are rare and there is little information about possible tolerance to other semisynthetic penicillins or cephalosporins in patients with cloxacillin allergy.	[ { "ade": "hypersensitivity", "drug": "cloxacillin" }, { "ade": "IgE-mediated allergic reactions", "drug": "cloxacillin" } ]
To our knowledge, these cases represent the first reports of TDF-associated irreversible renal failure and rickets in pediatric patients.	[ { "ade": "irreversible renal failure", "drug": "TDF" }, { "ade": "rickets", "drug": "TDF" } ]
Renal tubular acidosis secondary to FK506 in living donor liver transplantation: a case report.	[ { "ade": "Renal tubular acidosis", "drug": "FK506" } ]
Dyspnea possibly associated with controlled-release morphine sulfate tablets.	[ { "ade": "Dyspnea", "drug": "morphine sulfate" } ]
Disseminated tuberculous lesions post intravesical BCG therapy are rare but need to be identified and treated quickly.	[ { "ade": "Disseminated tuberculous lesions", "drug": "BCG" } ]
We report the occurrence of renal failure due to cholesterol crystal embolization following thrombolytic therapy with intravenous recombinant tissue-type plasminogen activator (t-PA).	[ { "ade": "cholesterol crystal embolization", "drug": "t-PA" }, { "ade": "cholesterol crystal embolization", "drug": "recombinant tissue-type plasminogen activator" }, { "ade": "renal failure", "drug": "recombinant tissue-type plasminogen activator" }, { "ade": "renal failure", "drug": "t-PA" } ]
Since elevated cortisol levels in Cushing's disease poses a threat for pancreatitis, there is a possibility that patients with Cushing's disease might be more prone to acute pancreatitis following propofol administration.	[ { "ade": "acute pancreatitis", "drug": "propofol" } ]
Succinylcholine-induced hyperkalemia in a patient with mucositis secondary to chemotherapy.	[ { "ade": "hyperkalemia", "drug": "Succinylcholine" } ]
Soon after introduction of insulin therapy, she developed severe anasarca, including marked peripheral oedema, ascites and pleural effusion.	[ { "ade": "pleural effusion", "drug": "insulin" }, { "ade": "peripheral oedema", "drug": "insulin" }, { "ade": "severe anasarca", "drug": "insulin" }, { "ade": "ascites", "drug": "insulin" } ]
Transtentorial herniation caused by an intracranial mass lesion following high-dose methotrexate.	[ { "ade": "intracranial mass lesion", "drug": "methotrexate" }, { "ade": "Transtentorial herniation", "drug": "methotrexate" } ]
However, other factors or drugs (e.g. cresol) are thought to induce MH.	[ { "ade": "MH", "drug": "cresol" } ]
Does acyclovir increase serum lithium levels?	[ { "ade": "increase serum lithium levels", "drug": "acyclovir" } ]
Sarcoma complicating therapy with cyclophosphamide.	[ { "ade": "Sarcoma", "drug": "cyclophosphamide" } ]
Among 12 thyrotoxic patients, a patient with arrhythmogenic right ventricular dysplasia, who had been taking amiodarone for 4 years, developed thyrotoxicosis with subacute onset, accompanied by transiently positive thyrotropin (TSH) receptor antibody (TRAb), or thyrotropin-binding inhibiting immunoglobulin (TBII).	[ { "ade": "thyrotropin-binding inhibiting immunoglobulin", "drug": "amiodarone" }, { "ade": "thyrotoxicosis", "drug": "amiodarone" }, { "ade": "transiently positive thyrotropin (TSH) receptor antibody", "drug": "amiodarone" } ]
Except hypothyroidism after radioiodine treatment (euthyroid under substitutional therapy), she suffered from no other diseases.	[ { "ade": "hypothyroidism", "drug": "radioiodine" } ]
CONCLUSIONS: This case report showed that the clinical appearance of Hashimoto's disease after IFN-alpha therapy for chronic C hepatitis in our patient was associated with a specific genetic predisposition (DR5) for this pathology.	[ { "ade": "Hashimoto's disease", "drug": "IFN-alpha" } ]
Deposits of plasma proteins in the skin during treatment with carbamazepine and diphenylhydantoin.	[ { "ade": "Deposits of plasma proteins in the skin", "drug": "carbamazepine" }, { "ade": "Deposits of plasma proteins in the skin", "drug": "diphenylhydantoin" } ]
Warfarin-induced skin necrosis and heparin-induced thrombocytopenia following mitral valve replacement for marantic endocarditis.	[ { "ade": "skin necrosis", "drug": "Warfarin" }, { "ade": "thrombocytopenia", "drug": "heparin" } ]
Incidence of seizures in pediatric cancer patients treated with imipenem/cilastatin.	[ { "ade": "seizures", "drug": "imipenem" }, { "ade": "seizures", "drug": "cilastatin" } ]
Cardiac toxicity related to BCNU has not been described well.	[ { "ade": "Cardiac toxicity", "drug": "BCNU" } ]
Acute INH neurotoxicity was not suspected on the first admission; however, when readmitted 4 weeks later with another seizure, the diagnosis of acute INH neurotoxicity was made.	[ { "ade": "neurotoxicity", "drug": "INH" } ]
We report a 16-year-old male who developed nephrotic syndrome related to membranous glomerulopathy with clinical and serological evidence of systemic lupus erythematosus after treatment with griseofulvin.	[ { "ade": "systemic lupus erythematosus", "drug": "griseofulvin" }, { "ade": "nephrotic syndrome", "drug": "griseofulvin" } ]
Cefoxitin-associated renal failure.	[ { "ade": "renal failure", "drug": "Cefoxitin" } ]
One case of priapism occurred during heparin therapy for a previous surgical operation to the knee is reported.	[ { "ade": "priapism", "drug": "heparin" } ]
Delayed neurotoxicity of intraventricular interleukin-2: a case report.	[ { "ade": "neurotoxicity", "drug": "interleukin-2" } ]
The evidence of high plasmatic levels of CBZ and the absence of other aetiologic factors lead the authors to conclude that the overdose of CBZ could have represented the precipitating of the episode of acute pancreatitis.	[ { "ade": "acute pancreatitis", "drug": "CBZ" } ]
Thus, clinical recognition of sleep disordered breathing should be taken into account when rheumatoid arthritis patients are to be treated with infliximab.	[ { "ade": "sleep disordered breathing", "drug": "infliximab" } ]
This article reports the occurrence of rifampin-associated thrombocytopenia in an indigent patient after a four-month lapse in therapy for pulmonary tuberculosis.	[ { "ade": "thrombocytopenia", "drug": "rifampin" } ]
We report a case of seizure associated with L-asparaginase therapy but no evidence of hemorrhagic or thrombotic cerebrovascular events.	[ { "ade": "seizure", "drug": "L-asparaginase" } ]
While for ribavirin antidepressant effects are not known, we suppose that antidepressants may prevent changes in serotonergic or noradrenergic neurotransmission caused by IFN-alpha.	[ { "ade": "changes in serotonergic or noradrenergic neurotransmission", "drug": "IFN-alpha" } ]
Neurophysiological mechanisms which aid in elucidating the role of disulfiram in the etiology of catatonia are discussed.	[ { "ade": "catatonia", "drug": "disulfiram" } ]
Autopsy evidence of herpesvirus infection was found in visceral organs of four leukemic patients who had received large doses of cytarabine (cytosine arabinoside; Ara-C) shortly before their death.	[ { "ade": "herpesvirus infection", "drug": "cytarabine" }, { "ade": "herpesvirus infection", "drug": "cytosine arabinoside" }, { "ade": "herpesvirus infection", "drug": "Ara-C" } ]

We report a patient with advanced colonic carcinoma who was treated with concomitant chemoirradiation with oxaliplatin and developed a peculiar dermnatitis in the irradiated field after being exposed to subsequent chemotherapy with oxaliplatin.

[ { "ade": "dermnatitis", "drug": "oxaliplatin" } ]

Naproxen is a commonly used nonsteroidal anti-inflammatory drug (NSAID) whose side effects include tinnitus and transient hearing loss.

[ { "ade": "transient hearing loss", "drug": "Naproxen" }, { "ade": "tinnitus", "drug": "Naproxen" } ]

Moreover, these findings suggest that the incidence of BOOP following rituximab therapy may be higher than has been previously appreciated.

[ { "ade": "BOOP", "drug": "rituximab" } ]

Interference with the cortisol axis by the microtubule antagonist, CPH82.

[ { "ade": "Interference with the cortisol axis", "drug": "CPH82" } ]

We report three cases of severe hepatotoxicity related to benzarone, a benzofuran derivative.

[ { "ade": "severe hepatotoxicity", "drug": "benzarone" } ]

Ovarian endometrioid adenocarcinoma arising from an endometriotic cyst in a postmenopausal woman under tamoxifen therapy for breast cancer: a case report.

[ { "ade": "Ovarian endometrioid adenocarcinoma", "drug": "tamoxifen" } ]

Leflunomide-induced toxic epidermal necrolysis in a patient with rheumatoid arthritis.

[ { "ade": "toxic epidermal necrolysis", "drug": "Leflunomide" } ]

Clinicians should be cognizant of this possibility and consider a diagnosis of HDAs in patients with ongoing thrombosis who are receiving heparin therapy.

[ { "ade": "thrombosis", "drug": "heparin" } ]

Clostridium difficile toxin-induced colitis after use of clindamycin phosphate vaginal cream.

[ { "ade": "Clostridium difficile toxin-induced colitis", "drug": "clindamycin phosphate" } ]

They seemed to involve multiple aetiological factors, such as autoimmune thyroid disease, the toxic and immunomodulatory roles of lithium and perhaps genetic and dietary factors.

[ { "ade": "toxic and immunomodulatory roles", "drug": "lithium" } ]

Reversible corneal keratinization following trabeculectomy and treatment with 5-fluorouracil.

[ { "ade": "Reversible corneal keratinization", "drug": "5-fluorouracil" } ]

Marked QT prolongation and torsades de pointes secondary to acute ischemia in an elderly man taking dofetilide for atrial fibrillation: a cautionary tale.

[ { "ade": "Marked QT prolongation", "drug": "dofetilide" }, { "ade": "acute ischemia", "drug": "dofetilide" }, { "ade": "torsades de pointes", "drug": "dofetilide" } ]

Methadone-induced myoclonus in advanced cancer.

[ { "ade": "myoclonus", "drug": "Methadone" } ]

Dapsone-induced erythroderma with Beau's lines.

[ { "ade": "erythroderma", "drug": "Dapsone" } ]

Near fatal acute colchicine intoxication in a child.

[ { "ade": "Near fatal", "drug": "colchicine" }, { "ade": "colchicine intoxication", "drug": "colchicine" } ]

Acute nitrite toxicity results from industrial exposure, accidental ingestion (e.g., abuse of organic nitrites as an aphrodisiac, especially in the male homosexual population), and suicidal ingestion.

[ { "ade": "nitrite toxicity", "drug": "nitrite" } ]

We conclude that the presence of this metabolic defect combined with topical 5-FU (a drug demonstrating a narrow therapeutic index) results in the unusual presentation of life-threatening toxicity after treatment with a topical drug.

[ { "ade": "life-threatening toxicity", "drug": "5-FU" } ]

Sirolimus-associated hepatotoxicity in the kidney graft recipient.

[ { "ade": "hepatotoxicity", "drug": "Sirolimus" } ]

Marked sinus tachycardia resulting from the synergistic effects of marijuana and nortriptyline.

[ { "ade": "sinus tachycardia", "drug": "nortriptyline" } ]

However, the amount of prednisone required to maintain normotension resulted in Cushingoid features and has been discontinued.

[ { "ade": "Cushingoid features", "drug": "prednisone" } ]

Carbamazepine toxicity following Oxybutynin and Dantrolene administration: a case report.

[ { "ade": "Carbamazepine toxicity", "drug": "Dantrolene" }, { "ade": "Carbamazepine toxicity", "drug": "Oxybutynin" }, { "ade": "Carbamazepine toxicity", "drug": "Carbamazepine" } ]

PURPOSE: To describe transient structured visual hallucinations in a patient with vascular age-related macular degeneration (AMD), following an intravitreal Avastin-injection.

[ { "ade": "transient structured visual hallucinations", "drug": "Avastin" } ]

The aim of this paper is to report the case of rosaceiform eruption induced by erlotinib in an 81-year-old-man and to discuss the pathogenetic role of Demodex folliculorum mites, found in the present patient, using skin scraping.

[ { "ade": "rosaceiform eruption", "drug": "erlotinib" } ]

A 25-year-old woman sought medical attention because of iliocaval manifestations of retroperitoneal fibrosis while she was taking methysergide.

[ { "ade": "retroperitoneal fibrosis", "drug": "methysergide" } ]

Alveolar-interstitial pneumopathy after gold-salts compounds administration, requiring mechanical ventilation.

[ { "ade": "Alveolar-interstitial pneumopathy", "drug": "gold" } ]

Intraventricular nafcillin-induced seizures in a neonate.

[ { "ade": "seizures", "drug": "nafcillin" } ]

The authors describe valproate-induced hyperammonemia and mental status changes in an 88-year-old man, the first known reported case in an elderly patient.

[ { "ade": "hyperammonemia", "drug": "valproate" }, { "ade": "mental status changes", "drug": "valproate" } ]

The possible effects of tamoxifen upon the uterus are discussed in this article, in view of reports of tamoxifen associated with endometrial carcinoma and endometriosis.

[ { "ade": "endometriosis", "drug": "tamoxifen" }, { "ade": "endometrial carcinoma", "drug": "tamoxifen" } ]

The polycystic changes disappeared from the ovaries in 2 of the women after valproate therapy was discontinued, and the 2 women who had gained weight and developed amenorrhea while being treated with valproate lost weight and resumed menstruating after the change in medication.

[ { "ade": "amenorrhea", "drug": "valproate" }, { "ade": "gained weight", "drug": "valproate" }, { "ade": "polycystic changes", "drug": "valproate" } ]

A 2-year-old mentally retarded boy with frontal lobe epilepsy presented with an episode that resembled heat stroke during the administration of zonisamide.

[ { "ade": "heat stroke", "drug": "zonisamide" } ]

CASE REPORT: We report a case of acute severe hepatitis resulting from erlotinib monotherapy in a patient with locally advanced pancreatic cancer.

[ { "ade": "acute severe hepatitis", "drug": "erlotinib" } ]

According to the Naranjo et al. adverse-reaction probability scale, enoxaparin was the probable cause of hepatotoxicity in this patient.

[ { "ade": "hepatotoxicity", "drug": "enoxaparin" } ]

However, a large case-control study included three cases of either Stevens-Johnson syndrome or toxic epidermal necrolysis associated with ofloxacin use, but no details of the cases were given.

[ { "ade": "toxic epidermal necrolysis", "drug": "ofloxacin" }, { "ade": "Stevens-Johnson syndrome", "drug": "ofloxacin" } ]

We describe a patient with rheumatoid arthritis treated with gold salts, who developed bilateral interstitial pulmonary abnormalities and showed a dramatic response on corticosteroid therapy.

[ { "ade": "bilateral interstitial pulmonary abnormalities", "drug": "gold" } ]

In this article lithium is not discussed, although there are a number of concerns about lithium's potential teratogenicity, and it has been implicated in Epstein's anomaly, a congenital heart defect among infants born to women taking lithium; as with other medications, however, the data have specific limitations.

[ { "ade": "teratogenicity", "drug": "lithium" }, { "ade": "Epstein's anomaly", "drug": "lithium" } ]

In a female with acute lymphoblastic leukemia, inadvertent doxorubicin administration intrathecally caused severe, life-threatening, acute encephalopathy with high-pressure hydrocephalus.

[ { "ade": "high-pressure hydrocephalus", "drug": "doxorubicin" }, { "ade": "acute encephalopathy", "drug": "doxorubicin" } ]

Possible mechanisms by which clonidine decreases spasticity are described, probable mechanisms of induced bradycardia are reviewed, and specific treatment recommendations for the use of clonidine in spinal cord injured patients are presented.

[ { "ade": "bradycardia", "drug": "clonidine" } ]

Secondary acute myeloid leukemia after etoposide therapy for haemophagocytic lymphohistiocytosis.

[ { "ade": "acute myeloid leukemia", "drug": "etoposide" } ]

The mean time from starting MMF to the development of neutropenia was 4 months.

[ { "ade": "neutropenia", "drug": "MMF" } ]

However, 1 eye had vitreous hemorrhage after repeated injections of tPA.

[ { "ade": "vitreous hemorrhage", "drug": "tPA" } ]

These cases demonstrate that CBZ can induce simple motor tics in children.

[ { "ade": "motor tics", "drug": "CBZ" } ]

One patient was an 80-year-old woman who was admitted for Staphylococcus aureus knee arthritis after several intraarticular injections of sodium hyaluronate and corticosteroids.

[ { "ade": "Staphylococcus aureus knee arthritis", "drug": "sodium hyaluronate" }, { "ade": "Staphylococcus aureus knee arthritis", "drug": "corticosteroids" } ]

Fracture of the femoral neck occurred in one patient during PSL therapy, although the relationship between the fracture and PSL therapy was uncertain.

[ { "ade": "Fracture of the femoral neck", "drug": "PSL" } ]

Cutaneous ulceration: an unusual complication of intravenous pentamidine therapy.

[ { "ade": "Cutaneous ulceration", "drug": "pentamidine" } ]

Pancytopenia associated with 5-aminosalicylic acid use in a patient with Crohn's disease.

[ { "ade": "Pancytopenia", "drug": "5-aminosalicylic acid" } ]

A 54-year-old man, treated with amiodarone, developed thyrotoxicosis.

[ { "ade": "thyrotoxicosis", "drug": "amiodarone" } ]

Fatal pulmonary fibrosis following 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) therapy.

[ { "ade": "Fatal pulmonary fibrosis", "drug": "BCNU" }, { "ade": "Fatal pulmonary fibrosis", "drug": "1,3-bis(2-chloroethyl)-1-nitrosourea" } ]

A 57-year-old man developed morphea while taking bromocriptine.

[ { "ade": "morphea", "drug": "bromocriptine" } ]

Carboplatin hypersensitivity induced by low-dose paclitaxel/carboplatin in multiple platinum-treated patients with recurrent ovarian cancer.

[ { "ade": "hypersensitivity", "drug": "Carboplatin" }, { "ade": "hypersensitivity", "drug": "carboplatin" }, { "ade": "hypersensitivity", "drug": "paclitaxel" } ]

STUDY DESIGN: Case report of a 31-year-old woman who presented with toxic myelopathy due to intrathecal administration of doxorubicin.

[ { "ade": "toxic myelopathy", "drug": "doxorubicin" } ]

Withdrawal of Depakote resulted in resolution of the effusion.

[ { "ade": "effusion", "drug": "Depakote" } ]

Severe C. difficile colitis occurred in 2 patients (6.1%) after receiving cisplatin-based combination chemotherapy for ovarian malignancies.

[ { "ade": "C. difficile colitis", "drug": "cisplatin" } ]

Patients with vitamin B12 deficiency are exceedingly sensitive to neurologic deterioration following nitrous oxide anesthesia.

[ { "ade": "neurologic deterioration", "drug": "nitrous oxide" } ]

Cimetidine-induced fever.

[ { "ade": "fever", "drug": "Cimetidine" } ]

Regardless of a negative history of asthma, therefore, life-threatening bronchospasm must be considered a possible complication of propranolol therapy.

[ { "ade": "bronchospasm", "drug": "propranolol" } ]

CONCLUSIONS: LTG overdose may result in a severe but reversible encephalopathy, a previously undescribed phenomenon.

[ { "ade": "encephalopathy", "drug": "LTG" } ]

This eruption emerged after 1 month of therapy with salsalate, persisted for as long as salsalate was administered, and cleared within 3 weeks of discontinuing the medication.

[ { "ade": "eruption", "drug": "salsalate" } ]

We report the case histories of two patients with histologically confirmed adenocarcinoma of the prostate, both of whom had been treated with steroidal anti-androgen therapy in the form of cyproterone acetate prior to radical or palliative pelvic irradiation, and who subsequently developed femoral head avascular necrosis.

[ { "ade": "femoral head avascular necrosis", "drug": "cyproterone acetate" } ]

Heparin-induced hyperkalemia.

[ { "ade": "hyperkalemia", "drug": "Heparin" } ]

Patients with lymphoblastic lymphoma who had treatment with L-asparaginase and steroid are predisposed to the development of cortical venous thrombosis and may have this syndrome in addition to a dural puncture headache.

[ { "ade": "cortical venous thrombosis", "drug": "L-asparaginase" }, { "ade": "dural puncture headache", "drug": "L-asparaginase" } ]

A rare case of advanced ovarian carcinoma who developed difficulty walking 25 days after treatment with weekly paclitaxel.

[ { "ade": "difficulty walking", "drug": "paclitaxel" } ]

The photosensitivity is still present 3 years after the withdrawal of quinine.

[ { "ade": "photosensitivity", "drug": "quinine" } ]

Symptomatic hypoglycemia secondary to a glipizide-trimethoprim/sulfamethoxazole drug interaction.

[ { "ade": "Symptomatic hypoglycemia", "drug": "sulfamethoxazole" }, { "ade": "Symptomatic hypoglycemia", "drug": "glipizide" }, { "ade": "Symptomatic hypoglycemia", "drug": "trimethoprim" } ]

Glomerulonephritis in procainamide induced lupus erythematosus: report of a case and review of the literature.

[ { "ade": "Glomerulonephritis", "drug": "procainamide" }, { "ade": "lupus erythematosus", "drug": "procainamide" } ]

Aggressive endometrial carcinoma in a breast cancer patient treated with tamoxifen with normal transvaginal ultrasonography.

[ { "ade": "Aggressive endometrial carcinoma", "drug": "tamoxifen" } ]

The risk of cardiac decompensation in infants with supraventricular tachycardia and congestive cardiac failure should be kept in mind prior to administration of verapamil.

[ { "ade": "cardiac decompensation", "drug": "verapamil" } ]

Interferon-alpha-induced hyperthyroidism: a three-stage evolution from silent thyroiditis towards Graves' disease.

[ { "ade": "hyperthyroidism", "drug": "Interferon-alpha" } ]

Relapse in the external auditory canal of acute promyelocytic leukemia after treatment with all-trans retinoic acid.

[ { "ade": "Relapse in the external auditory canal of acute promyelocytic leukemia", "drug": "all-trans retinoic acid" } ]

Several hypersensitivity reactions to cloxacillin have been reported, although IgE-mediated allergic reactions to the drug are rare and there is little information about possible tolerance to other semisynthetic penicillins or cephalosporins in patients with cloxacillin allergy.

[ { "ade": "hypersensitivity", "drug": "cloxacillin" }, { "ade": "IgE-mediated allergic reactions", "drug": "cloxacillin" } ]

To our knowledge, these cases represent the first reports of TDF-associated irreversible renal failure and rickets in pediatric patients.

[ { "ade": "irreversible renal failure", "drug": "TDF" }, { "ade": "rickets", "drug": "TDF" } ]

Renal tubular acidosis secondary to FK506 in living donor liver transplantation: a case report.

[ { "ade": "Renal tubular acidosis", "drug": "FK506" } ]

Dyspnea possibly associated with controlled-release morphine sulfate tablets.

[ { "ade": "Dyspnea", "drug": "morphine sulfate" } ]

Disseminated tuberculous lesions post intravesical BCG therapy are rare but need to be identified and treated quickly.

[ { "ade": "Disseminated tuberculous lesions", "drug": "BCG" } ]

We report the occurrence of renal failure due to cholesterol crystal embolization following thrombolytic therapy with intravenous recombinant tissue-type plasminogen activator (t-PA).

[ { "ade": "cholesterol crystal embolization", "drug": "t-PA" }, { "ade": "cholesterol crystal embolization", "drug": "recombinant tissue-type plasminogen activator" }, { "ade": "renal failure", "drug": "recombinant tissue-type plasminogen activator" }, { "ade": "renal failure", "drug": "t-PA" } ]

Since elevated cortisol levels in Cushing's disease poses a threat for pancreatitis, there is a possibility that patients with Cushing's disease might be more prone to acute pancreatitis following propofol administration.

[ { "ade": "acute pancreatitis", "drug": "propofol" } ]

Succinylcholine-induced hyperkalemia in a patient with mucositis secondary to chemotherapy.

[ { "ade": "hyperkalemia", "drug": "Succinylcholine" } ]

Soon after introduction of insulin therapy, she developed severe anasarca, including marked peripheral oedema, ascites and pleural effusion.

[ { "ade": "pleural effusion", "drug": "insulin" }, { "ade": "peripheral oedema", "drug": "insulin" }, { "ade": "severe anasarca", "drug": "insulin" }, { "ade": "ascites", "drug": "insulin" } ]

Transtentorial herniation caused by an intracranial mass lesion following high-dose methotrexate.

[ { "ade": "intracranial mass lesion", "drug": "methotrexate" }, { "ade": "Transtentorial herniation", "drug": "methotrexate" } ]

However, other factors or drugs (e.g. cresol) are thought to induce MH.

[ { "ade": "MH", "drug": "cresol" } ]

Does acyclovir increase serum lithium levels?

[ { "ade": "increase serum lithium levels", "drug": "acyclovir" } ]

Sarcoma complicating therapy with cyclophosphamide.

[ { "ade": "Sarcoma", "drug": "cyclophosphamide" } ]

Among 12 thyrotoxic patients, a patient with arrhythmogenic right ventricular dysplasia, who had been taking amiodarone for 4 years, developed thyrotoxicosis with subacute onset, accompanied by transiently positive thyrotropin (TSH) receptor antibody (TRAb), or thyrotropin-binding inhibiting immunoglobulin (TBII).

[ { "ade": "thyrotropin-binding inhibiting immunoglobulin", "drug": "amiodarone" }, { "ade": "thyrotoxicosis", "drug": "amiodarone" }, { "ade": "transiently positive thyrotropin (TSH) receptor antibody", "drug": "amiodarone" } ]

Except hypothyroidism after radioiodine treatment (euthyroid under substitutional therapy), she suffered from no other diseases.

[ { "ade": "hypothyroidism", "drug": "radioiodine" } ]

CONCLUSIONS: This case report showed that the clinical appearance of Hashimoto's disease after IFN-alpha therapy for chronic C hepatitis in our patient was associated with a specific genetic predisposition (DR5) for this pathology.

[ { "ade": "Hashimoto's disease", "drug": "IFN-alpha" } ]

Deposits of plasma proteins in the skin during treatment with carbamazepine and diphenylhydantoin.

[ { "ade": "Deposits of plasma proteins in the skin", "drug": "carbamazepine" }, { "ade": "Deposits of plasma proteins in the skin", "drug": "diphenylhydantoin" } ]

Warfarin-induced skin necrosis and heparin-induced thrombocytopenia following mitral valve replacement for marantic endocarditis.

[ { "ade": "skin necrosis", "drug": "Warfarin" }, { "ade": "thrombocytopenia", "drug": "heparin" } ]

Incidence of seizures in pediatric cancer patients treated with imipenem/cilastatin.

[ { "ade": "seizures", "drug": "imipenem" }, { "ade": "seizures", "drug": "cilastatin" } ]

Cardiac toxicity related to BCNU has not been described well.

[ { "ade": "Cardiac toxicity", "drug": "BCNU" } ]

Acute INH neurotoxicity was not suspected on the first admission; however, when readmitted 4 weeks later with another seizure, the diagnosis of acute INH neurotoxicity was made.

[ { "ade": "neurotoxicity", "drug": "INH" } ]

We report a 16-year-old male who developed nephrotic syndrome related to membranous glomerulopathy with clinical and serological evidence of systemic lupus erythematosus after treatment with griseofulvin.

[ { "ade": "systemic lupus erythematosus", "drug": "griseofulvin" }, { "ade": "nephrotic syndrome", "drug": "griseofulvin" } ]

Cefoxitin-associated renal failure.

[ { "ade": "renal failure", "drug": "Cefoxitin" } ]

One case of priapism occurred during heparin therapy for a previous surgical operation to the knee is reported.

[ { "ade": "priapism", "drug": "heparin" } ]

Delayed neurotoxicity of intraventricular interleukin-2: a case report.

[ { "ade": "neurotoxicity", "drug": "interleukin-2" } ]

The evidence of high plasmatic levels of CBZ and the absence of other aetiologic factors lead the authors to conclude that the overdose of CBZ could have represented the precipitating of the episode of acute pancreatitis.

[ { "ade": "acute pancreatitis", "drug": "CBZ" } ]

Thus, clinical recognition of sleep disordered breathing should be taken into account when rheumatoid arthritis patients are to be treated with infliximab.

[ { "ade": "sleep disordered breathing", "drug": "infliximab" } ]

This article reports the occurrence of rifampin-associated thrombocytopenia in an indigent patient after a four-month lapse in therapy for pulmonary tuberculosis.

[ { "ade": "thrombocytopenia", "drug": "rifampin" } ]

We report a case of seizure associated with L-asparaginase therapy but no evidence of hemorrhagic or thrombotic cerebrovascular events.

[ { "ade": "seizure", "drug": "L-asparaginase" } ]

While for ribavirin antidepressant effects are not known, we suppose that antidepressants may prevent changes in serotonergic or noradrenergic neurotransmission caused by IFN-alpha.

[ { "ade": "changes in serotonergic or noradrenergic neurotransmission", "drug": "IFN-alpha" } ]

Neurophysiological mechanisms which aid in elucidating the role of disulfiram in the etiology of catatonia are discussed.

[ { "ade": "catatonia", "drug": "disulfiram" } ]

Autopsy evidence of herpesvirus infection was found in visceral organs of four leukemic patients who had received large doses of cytarabine (cytosine arabinoside; Ara-C) shortly before their death.

[ { "ade": "herpesvirus infection", "drug": "cytarabine" }, { "ade": "herpesvirus infection", "drug": "cytosine arabinoside" }, { "ade": "herpesvirus infection", "drug": "Ara-C" } ]

Datasets:

mihirhirave
/

entity_extraction_ade_v2_with_validation

Dataset: Entity Extraction Adverse Drug Events with Validation Split

Dataset Structure

Features

Creation Process