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EEG abnormalities were observed in two of the nine children during chlorambucil therapy. | [
{
"ade": "EEG abnormalities",
"drug": "chlorambucil"
}
] |
Visual loss after a single small dose of vincristine has never been reported. | [
{
"ade": "Visual loss",
"drug": "vincristine"
}
] |
Development of an extensive skin rash following a single dose of MTX may be an early warning sign for life-threatening bone marrow aplasia. | [
{
"ade": "extensive skin rash",
"drug": "MTX"
}
] |
Exfoliative dermatitis secondary to tobramycin sulfate. | [
{
"ade": "Exfoliative dermatitis",
"drug": "tobramycin sulfate"
}
] |
A 56-year-old white woman with a diagnosis of reactive depression developed severe UI after a 30 days' treatment with venlafaxine 75 mg/day. | [
{
"ade": "UI",
"drug": "venlafaxine"
}
] |
We document the abrupt development of an extensive choroidal detachment after initiation of dorzolamide therapy in a surgically untreated eye with primary open-angle glaucoma. | [
{
"ade": "choroidal detachment",
"drug": "dorzolamide"
}
] |
This case demonstrates the association of selective IgA deficiency with remission in rheumatoid arthritis induced by fenclofenac as well as aurothiomalate and sulphasalazine. | [
{
"ade": "IgA deficiency",
"drug": "sulphasalazine"
},
{
"ade": "IgA deficiency",
"drug": "aurothiomalate"
},
{
"ade": "IgA deficiency",
"drug": "fenclofenac"
}
] |
We present the first case of a patient with priapism after oral intake of the phenothiazine prothipendylhydrochloride. | [
{
"ade": "priapism",
"drug": "prothipendylhydrochloride"
}
] |
Apparent cyclophosphamide (cytoxan) embryopathy: a distinct phenotype? | [
{
"ade": "embryopathy",
"drug": "cyclophosphamide"
}
] |
In this report we present four patients treated with a combination of different psychotropic drugs, in whom asterixis was triggered either by adding carbamazepine (CBZ) to a treatment regimen, or by increasing its dosage. | [
{
"ade": "asterixis",
"drug": "CBZ"
},
{
"ade": "asterixis",
"drug": "carbamazepine"
}
] |
We report a case of amiodarone-induced thyrotoxicosis of protracted duration, unresponsive to conventional thionamide therapy, with therapy limited by severe adverse drug reactions. | [
{
"ade": "thyrotoxicosis",
"drug": "amiodarone"
}
] |
Studies performed 10 years ago on 25 patients with MTX-induced liver cirrhosis indicated that this type of cirrhosis was not of an aggressive nature. | [
{
"ade": "cirrhosis",
"drug": "MTX"
},
{
"ade": "liver cirrhosis",
"drug": "MTX"
}
] |
A case of the Rett syndrome with acute encephalopathy induced during calcium hopantenate treatment. | [
{
"ade": "acute encephalopathy",
"drug": "calcium hopantenate"
}
] |
Case report: life-threatening hypoglycaemia associated with sulfadoxine-pyrimethamine, a commonly used antimalarial drug. | [
{
"ade": "life-threatening hypoglycaemia",
"drug": "sulfadoxine-pyrimethamine"
}
] |
Unaccountable severe hypercalcemia in a patient treated for hypoparathyroidism with dihydrotachysterol. | [
{
"ade": "hypercalcemia",
"drug": "dihydrotachysterol"
}
] |
Seven patients with hematologic malignancies who were treated with miconazole for either suspected or proven fungal infections developed eight episodes of major adverse cardiorespiratory and anaphylactic reactions. | [
{
"ade": "cardiorespiratory and anaphylactic reactions",
"drug": "miconazole"
}
] |
The authors report on two patients with corneal ulcers refractory to conventional treatment while the patients were undergoing oral colchicine therapy. | [
{
"ade": "corneal ulcers refractory to conventional treatment",
"drug": "colchicine"
}
] |
Ulcer became worse after tobramycin and gentamycin treatment for 2 days. | [
{
"ade": "Ulcer became worse",
"drug": "tobramycin"
},
{
"ade": "Ulcer became worse",
"drug": "gentamycin"
}
] |
Risperidone-induced psychosis and depression in a child with a mitochondrial disorder. | [
{
"ade": "depression",
"drug": "Risperidone"
},
{
"ade": "psychosis",
"drug": "Risperidone"
}
] |
Neurotoxicity of intrathecal methotrexate: MR imaging findings. | [
{
"ade": "Neurotoxicity",
"drug": "methotrexate"
}
] |
After treatment with a beta-sympathomimetic drug (Partusisten) one fetus developed supraventricular tachycardia. | [
{
"ade": "supraventricular tachycardia",
"drug": "Partusisten"
}
] |
A case of phenobarbital exacerbation of a preexisting maladaptive behavior partially suppressed by chlorpromazine and misinterpreted as chlorpromazine efficacy. | [
{
"ade": "exacerbation of a preexisting maladaptive behavior",
"drug": "phenobarbital"
}
] |
We believe that this represents an unusual case of moderate-dose MTX-induced neurotoxicity in a patient with gastric cancer, which has not previously been reported. | [
{
"ade": "neurotoxicity",
"drug": "MTX"
}
] |
Unusual pigmentary changes associated with 5-fluorouracil therapy. | [
{
"ade": "pigmentary changes",
"drug": "5-fluorouracil"
}
] |
Atenolol-induced pseudolymphoma. | [
{
"ade": "pseudolymphoma",
"drug": "Atenolol"
}
] |
Subsequent in vivo/vitro studies clearly demonstrated that the neurological effects were due to a synergistic action of desferrioxamine and prochlorperazine, probably resulting in exceptional fluxes of intra/extra cellular iron/copper disturbing noradrenergic and serotonergic systems. | [
{
"ade": "neurological effects",
"drug": "desferrioxamine"
},
{
"ade": "neurological effects",
"drug": "prochlorperazine"
}
] |
A 56-year-old Caucasian man who received concomitant chemotherapy and radiation for head and neck cancer developed fever concurrent with the administration of amifostine. | [
{
"ade": "fever",
"drug": "amifostine"
}
] |
CONCLUSION: The chronic use of HCQ for rheumatic diseases, or as an anti-malarial drug, should be balanced against the risk of developing potentially lethal cardiac arrhythmias. | [
{
"ade": "cardiac arrhythmias",
"drug": "HCQ"
}
] |
Similar to reports in patients receiving gefitinib, those with pathologic findings of UIP on resected lung specimens or known pulmonary fibrosis may be at particular risk for erlotinib pulmonary toxicity. | [
{
"ade": "pulmonary fibrosis",
"drug": "erlotinib"
},
{
"ade": "pulmonary toxicity",
"drug": "erlotinib"
}
] |
This is the first reported case of hepatolithiasis during octreotide therapy. | [
{
"ade": "hepatolithiasis",
"drug": "octreotide"
}
] |
CONCLUSIONS: This case suggests that losartan can induce late-onset angioedema in patients with normal renal function and that the reaction can recur after initial resolution of the symptoms. | [
{
"ade": "angioedema",
"drug": "losartan"
}
] |
Carbamazepine-induced systemic lupus erythematosus. | [
{
"ade": "systemic lupus erythematosus",
"drug": "Carbamazepine"
}
] |
We present a case in which dipyridamole induced high-grade atrioventricular (AV) block that responded promptly to intravenous aminophylline but not to atropine. | [
{
"ade": "high-grade atrioventricular (AV) block",
"drug": "dipyridamole"
}
] |
Esophageal spasm following propranolol overdose relieved by glucagon. | [
{
"ade": "Esophageal spasm",
"drug": "propranolol"
}
] |
Nicotinic acid-induced fulminant hepatic failure. | [
{
"ade": "fulminant hepatic failure",
"drug": "Nicotinic acid"
}
] |
Acute leukopenia associated with silver sulfadiazine therapy. | [
{
"ade": "Acute leukopenia",
"drug": "silver sulfadiazine"
}
] |
Escape atrial complexes, which occurred following junctional premature complexes, failed to initiate tachycardia in the control state but tachycardia was always reinitiated by an identical escape sequence after procainamide. | [
{
"ade": "tachycardia",
"drug": "procainamide"
}
] |
Hyperammonemia has been described as a complication of valproic acid therapy but may often be overlooked as a cause of lethargy in the postictal patient who presents to the emergency department. | [
{
"ade": "lethargy",
"drug": "valproic acid"
},
{
"ade": "Hyperammonemia",
"drug": "valproic acid"
}
] |
This is a unique autopsy case of hepatocellular carcinoma closely related to diethylstilbestrol (DES) therapy for prostatic cancer. | [
{
"ade": "hepatocellular carcinoma",
"drug": "diethylstilbestrol"
},
{
"ade": "hepatocellular carcinoma",
"drug": "DES"
}
] |
Severe abdominal pain in low dosage clofazimine. | [
{
"ade": "abdominal pain",
"drug": "clofazimine"
}
] |
A previous review described data on 15 patients who experienced acute hemoglobinemia or hemoglobinuria following anti-D IGIV administration for ITP or secondary thrombocytopenia. | [
{
"ade": "acute hemoglobinemia",
"drug": "anti-D IGIV"
},
{
"ade": "hemoglobinuria",
"drug": "anti-D IGIV"
}
] |
Fixed drug eruption of the scrotum due to methylphenidate. | [
{
"ade": "Fixed drug eruption of the scrotum",
"drug": "methylphenidate"
}
] |
A unique case of a transient, nonpigmenting fixed drug eruption caused by the radiopaque contrast medium iothalamate is reported. | [
{
"ade": "fixed drug eruption",
"drug": "iothalamate"
}
] |
An unusual cause of burn injury: unsupervised use of drugs that contain psoralens. | [
{
"ade": "psoralens",
"drug": "burn injury"
}
] |
Renal damage associated with long term use of lithium carbonate. | [
{
"ade": "Renal damage",
"drug": "lithium carbonate"
}
] |
Disseminated intravascular coagulation associated with acute hemoglobinemia or hemoglobinuria following Rh(0)(D) immune globulin intravenous administration for immune thrombocytopenic purpura. | [
{
"ade": "hemoglobinuria",
"drug": "Rh(0)(D) immune globulin"
},
{
"ade": "Disseminated intravascular coagulation",
"drug": "Rh(0)(D) immune globulin"
},
{
"ade": "acute hemoglobinemia",
"drug": "Rh(0)(D) immune globulin"
}
] |
Such anagen effluvium with lichenoid eruption following INH therapy has not been observed previously. | [
{
"ade": "lichenoid eruption",
"drug": "INH"
},
{
"ade": "anagen effluvium",
"drug": "INH"
}
] |
Both patients were then treated with a carboplatin alternative to cisplatin in the following courses, which resulted in neither a relapse of the colitis nor a recurrence of the malignancies up to this time. | [
{
"ade": "colitis",
"drug": "cisplatin"
}
] |
With the negative viral serologies, the clinical picture was most consistent with an infectious mononucleosis-like syndrome produced by the minocycline ingestion. | [
{
"ade": "mononucleosis-like syndrome",
"drug": "minocycline"
}
] |
Verapamil in effort-induced angina pectoris in patients with normal coronary arteries. | [
{
"ade": "angina pectoris",
"drug": "Verapamil"
}
] |
Atrial fibrillation following methylprednisolone pulse therapy. | [
{
"ade": "Atrial fibrillation",
"drug": "methylprednisolone"
}
] |
Two years later, 24 hours following an increase in the dose of disopyramide from 300 to 600 mg/day, AVT with syncope occurred; isoproterenol abolished the arrhythmia instantly. | [
{
"ade": "AVT",
"drug": "disopyramide"
},
{
"ade": "syncope",
"drug": "disopyramide"
}
] |
We report a patient with pulmonary adenocarcinoma complicated by the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) following systemic chemotherapy with cisplatin (CDDP) and vindesine (VDS). | [
{
"ade": "syndrome of inappropriate secretion of antidiuretic hormone",
"drug": "cisplatin"
},
{
"ade": "SIADH",
"drug": "vindesine"
},
{
"ade": "syndrome of inappropriate secretion of antidiuretic hormone",
"drug": "CDDP"
},
{
"ade": "SIADH",
"drug": "CDDP"
},
{
"ade": "syndrome of inappropriate secretion of antidiuretic hormone",
"drug": "vindesine"
},
{
"ade": "SIADH",
"drug": "cisplatin"
},
{
"ade": "SIADH",
"drug": "VDS"
},
{
"ade": "syndrome of inappropriate secretion of antidiuretic hormone",
"drug": "VDS"
}
] |
CONCLUSIONS: Although budesonide may be beneficial because of its anti-inflammatory effects, clinicians should be alert to its potential for causing contact dermatitis. | [
{
"ade": "contact dermatitis",
"drug": "budesonide"
}
] |
The possibility can be raised that M-CSF accelerated the underlying renal disease in this case through enhancing macrophage accumulation into the glomerulus, leading to the development of nephrotic syndrome. | [
{
"ade": "nephrotic syndrome",
"drug": "M-CSF"
},
{
"ade": "renal disease",
"drug": "M-CSF"
}
] |
Colonic necrosis is known as a rare complication following the administration of Kayexalate (sodium polystryrene sulfonate) in sorbitol. | [
{
"ade": "Colonic necrosis",
"drug": "sodium polystryrene sulfonate"
},
{
"ade": "Colonic necrosis",
"drug": "Kayexalate"
}
] |
Cyanamide-induced liver dysfunction after abstinence in alcoholics: a long-term follow-up study on four cases. | [
{
"ade": "liver dysfunction",
"drug": "Cyanamide"
}
] |
A 56-year-old woman with scleroderma developed rapidly progressive glomerulonephritis with epithelial crescents associated with hemoptysis after 27 months of D-penicillamine therapy and a cumulative dose of 1,200 g. | [
{
"ade": "rapidly progressive glomerulonephritis",
"drug": "D-penicillamine"
},
{
"ade": "epithelial crescents",
"drug": "D-penicillamine"
},
{
"ade": "hemoptysis",
"drug": "D-penicillamine"
}
] |
We suggest adding this side effect to the list of untoward effects of lidocaine and to the differential diagnosis of fixed dilated pupils in neonates treated with lidocaine. | [
{
"ade": "dilated pupils",
"drug": "lidocaine"
}
] |
Native arterial thrombosis, though recognized as a severe complication of thrombin injection, has not been well described in the literature. | [
{
"ade": "arterial thrombosis",
"drug": "thrombin"
}
] |
A woman 38-year-old, suffering for about ten years from multiple sclerosis and treated with repeated therapy cycles of intrathecal Depo-Medrol, developed a spastic paraparesis at the lower limbs. | [
{
"ade": "spastic paraparesis at the lower limbs",
"drug": "Depo-Medrol"
}
] |
Fluoxetine-related death in a child with cytochrome P-450 2D6 genetic deficiency. | [
{
"ade": "death",
"drug": "Fluoxetine"
}
] |
We report a child with yolk sac tumor who developed localized pigmentation after the first course of chemotherapy regimen that included cisplatin, etoposide and bleomycin. | [
{
"ade": "localized pigmentation",
"drug": "cisplatin"
},
{
"ade": "localized pigmentation",
"drug": "etoposide"
},
{
"ade": "localized pigmentation",
"drug": "bleomycin"
}
] |
Retinal abnormalities, including retinal hemorrhage and "cotton-wool" spots, often occur within the first 8 weeks in the course of interferon therapy in patients with chronic hepatitis C. | [
{
"ade": "\"cotton-wool\" spots",
"drug": "interferon"
},
{
"ade": "retinal hemorrhage",
"drug": "interferon"
},
{
"ade": "Retinal abnormalities",
"drug": "interferon"
}
] |
The current study investigated the visual fields and visual electrophysiology of eight patients with known vigabatrin-attributed visual field loss, three of whom were reported previously. | [
{
"ade": "visual field loss",
"drug": "vigabatrin"
}
] |
Case report of withdrawal dyskinesia associated with amoxapine. | [
{
"ade": "dyskinesia",
"drug": "amoxapine"
}
] |
Thus, the eosinophilia myalgia syndrome can be associated with parenteral tryptophan administration. | [
{
"ade": "eosinophilia myalgia syndrome",
"drug": "tryptophan"
}
] |
This is, to the best of our knowledge, the first report of a case in which agranulocytosis followed treatment with both propylthiouracil and methimazole in the same patient. | [
{
"ade": "agranulocytosis",
"drug": "propylthiouracil"
},
{
"ade": "agranulocytosis",
"drug": "methimazole"
}
] |
However, follow-up revealed that gestational diabetes when associated with norethisterone had a lesser risk of emerging diabetes mellitus and impaired glucose tolerance. | [
{
"ade": "diabetes mellitus",
"drug": "norethisterone"
},
{
"ade": "impaired glucose tolerance",
"drug": "norethisterone"
},
{
"ade": "gestational diabetes",
"drug": "norethisterone"
}
] |
We report the first case of polymorphic ventricular tachycardia with normal QT interval associated with the oral use of levofloxacin in the absence of other etiologies known to cause these arrhythmias. | [
{
"ade": "polymorphic ventricular tachycardia",
"drug": "levofloxacin"
}
] |
Acute dystonia during pegylated interferon alpha therapy in a case with chronic hepatitis B infection. | [
{
"ade": "Acute dystonia",
"drug": "pegylated interferon alpha"
}
] |
The first case concerns a 70-year-old man who developed severe aplastic anemia 7 weeks after treatment with 500 mg of ticlopidine daily. | [
{
"ade": "aplastic anemia",
"drug": "ticlopidine"
}
] |
Metastatic osteomyelitis following BCG vaccination. | [
{
"ade": "Metastatic osteomyelitis",
"drug": "BCG"
}
] |
Hepatotoxicity of paracetamol enhanced by ingestion of alcohol: report of two cases. | [
{
"ade": "Hepatotoxicity",
"drug": "paracetamol"
}
] |
While 40 mg/day of prednisolone improved hepatic dysfunction dramatically, her diabetic milieu deteriorated seriously. | [
{
"ade": "diabetic milieu deteriorated",
"drug": "prednisolone"
}
] |
Can magnesium sulfate therapy impact lactogenesis? | [
{
"ade": "lactogenesis",
"drug": "magnesium sulfate"
}
] |
The authors postulate that two types of combined lithium-neuroleptic toxicity occur: a neuroleptic malignant extrapyramidal syndrome and a lithium toxicity that occurs in combination with phenothiazines, primarily thioridazine. | [
{
"ade": "neuroleptic malignant extrapyramidal syndrome",
"drug": "thioridazine"
},
{
"ade": "lithium toxicity",
"drug": "lithium"
},
{
"ade": "lithium toxicity",
"drug": "thioridazine"
},
{
"ade": "neuroleptic malignant extrapyramidal syndrome",
"drug": "lithium"
}
] |
First case of ivermectin-induced severe hepatitis. | [
{
"ade": "severe hepatitis",
"drug": "ivermectin"
}
] |
CONCLUSION: Acetic acid is corrosive and may cause vagina bleeding. | [
{
"ade": "vagina bleeding",
"drug": "Acetic acid"
}
] |
Lower extremity arterial insufficiency after long-term methysergide maleate therapy. | [
{
"ade": "arterial insufficiency",
"drug": "methysergide maleate"
}
] |
Prolongation of the QT interval and ventricular tachyarrhymias have been described in patients on amiodarone therapy. | [
{
"ade": "Prolongation of the QT interval",
"drug": "amiodarone"
},
{
"ade": "ventricular tachyarrhymias",
"drug": "amiodarone"
}
] |
The following is a case report analysis intended to draw attention to the need for better care coordination by describing the observed relationship of olanzapine to metabolic changes manifested as uncontrolled diabetes mellitus and weight gain. | [
{
"ade": "uncontrolled diabetes mellitus",
"drug": "olanzapine"
},
{
"ade": "weight gain",
"drug": "olanzapine"
}
] |
We report 3 patients with severe hepatocellular damage due to CPA therapy, 2 with fatal fulminant hepatitis. | [
{
"ade": "fatal fulminant hepatitis",
"drug": "CPA"
},
{
"ade": "severe hepatocellular damage",
"drug": "CPA"
}
] |
Type II heparin-induced thrombocytopenia (HIT) is an immunological disorder characterized by antibodies to heparin-platelet factor 4 complexes and a high risk of thrombotic complications. | [
{
"ade": "thrombocytopenia",
"drug": "heparin"
}
] |
Caution is, therefore, needed to prevent undesired accumulation of TCA that may lead to protracted Cushing's syndrome. | [
{
"ade": "Cushing's syndrome",
"drug": "TCA"
}
] |
One patient with systemic lupus erythematosus developed erythema multiforme after taking griseofulvin. | [
{
"ade": "erythema multiforme",
"drug": "griseofulvin"
}
] |
Detection of activated eosinophils in nasal polyps of an aspirin-induced asthma patient. | [
{
"ade": "asthma",
"drug": "aspirin"
}
] |
However, given the clinically significant result to the interaction between tolazoline and cimetidine we report, the use of cimetidine in tolazoline induced upper gastrointestinal hemorrhage should deserve more attention. | [
{
"ade": "upper gastrointestinal hemorrhage",
"drug": "tolazoline"
},
{
"ade": "upper gastrointestinal hemorrhage",
"drug": "cimetidine"
}
] |
Acetazolamide may have accelerated the development of osteomalacia by several mechanisms, including increased renal calcium excretion. | [
{
"ade": "osteomalacia",
"drug": "Acetazolamide"
}
] |
Protamine-induced fatal anaphylaxis. | [
{
"ade": "fatal anaphylaxis",
"drug": "Protamine"
}
] |
Osteonecrosis is a serious side effect of antiemetic treatment with dexamethasone and this serious complication should be incorporated in the current guidelines. | [
{
"ade": "Osteonecrosis",
"drug": "dexamethasone"
}
] |
This regimen could prove useful for other patients who develop hypersensitivity reactions to carboplatin and allow therapy to continue. | [
{
"ade": "hypersensitivity",
"drug": "carboplatin"
}
] |
RESULTS: A 52-year-old woman with Parkinson disease who had taken amantadine for 6 years had bilateral corneal edema for 2 months at baseline. | [
{
"ade": "bilateral corneal edema",
"drug": "amantadine"
}
] |
The presented patient was treated with 200 mg TCA and developed Cushing's syndrome 6 weeks later (cortisol and ACTH concentrations were below limits of detection, TCA concentrations were > 3 micrograms/l). | [
{
"ade": "Cushing's syndrome",
"drug": "TCA"
}
] |
The second patient, who developed cholestasis after receiving trimethoprim-sulfamethoxazole, had marked duct paucity in the liver biopsy. | [
{
"ade": "duct paucity",
"drug": "trimethoprim-sulfamethoxazole"
},
{
"ade": "cholestasis",
"drug": "trimethoprim-sulfamethoxazole"
}
] |
A 67-year-old patient, with primary polymyositis and without previous evidence of liver disease, developed clinical and biochemical features of severe cholestasis 3 months after initiation of azathioprine therapy. | [
{
"ade": "severe cholestasis",
"drug": "azathioprine"
}
] |
CONCLUSIONS: It is probable that foscarnet contributed to the electrolyte disorders and symptomatology in this patient. | [
{
"ade": "electrolyte disorders",
"drug": "foscarnet"
}
] |
There are, however, case studies describing patients experiencing recurrences of tics following treatment with atomoxetine. | [
{
"ade": "tics",
"drug": "atomoxetine"
}
] |
A second possibility is an interaction between clarithromycin and isradipine, potentially increasing the hepatic toxicity of isradipine. | [
{
"ade": "increasing the hepatic toxicity",
"drug": "isradipine"
},
{
"ade": "increasing the hepatic toxicity",
"drug": "clarithromycin"
}
] |
Gangrene of the fingertips after bleomycin and methotrexate. | [
{
"ade": "Gangrene",
"drug": "bleomycin"
},
{
"ade": "Gangrene",
"drug": "methotrexate"
}
] |
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