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Theophylline intoxication mimicking diabetic ketoacidosis in a child. | [
{
"ade": "Theophylline intoxication",
"drug": "Theophylline"
}
] |
The pulmonary toxicity of gold salts is an uncommon cause of life-threatening respiratory failure. | [
{
"ade": "respiratory failure",
"drug": "gold"
},
{
"ade": "pulmonary toxicity",
"drug": "gold"
}
] |
In this report, we describe a fatal gemcitabine-induced pulmonary toxicity in a patient with gallbladder metastatic adenocarcinoma. | [
{
"ade": "pulmonary toxicity",
"drug": "gemcitabine"
}
] |
Methotrexate induced sprue-like syndrome. | [
{
"ade": "sprue-like syndrome",
"drug": "Methotrexate"
}
] |
Pancreatitis is a very rare adverse effect associated with the use of amiodarone, and only four cases of amiodarone-induced pancreatitis have been reported in literature. | [
{
"ade": "pancreatitis",
"drug": "amiodarone"
},
{
"ade": "Pancreatitis",
"drug": "amiodarone"
}
] |
In this paper, we report a patient with primary anti-phospholipid syndrome treated by corticosteroid, who developed disseminated nocardiosis. | [
{
"ade": "disseminated nocardiosis",
"drug": "corticosteroid"
}
] |
CONCLUSION: Marked visual field constriction appears to be associated with vigabatrin therapy. | [
{
"ade": "visual field constriction",
"drug": "vigabatrin"
}
] |
The patient whose case is reviewed had migraine headaches and received methysergide maleate for 13 years. | [
{
"ade": "migraine headaches",
"drug": "methysergide"
}
] |
A 10-year-old asthmatic boy began to suffer from urticarial rash and moderately severe bronchospasm after 8 weeks' treatment with disodium cromoglycate. | [
{
"ade": "moderately severe bronchospasm",
"drug": "disodium cromoglycate"
},
{
"ade": "urticarial rash",
"drug": "disodium cromoglycate"
}
] |
OBJECTIVE: To present a single case of zuclopenthixol-induced priapism and a literature review. | [
{
"ade": "priapism",
"drug": "zuclopenthixol"
}
] |
Refractory hypoglycemia from ciprofloxacin and glyburide interaction. | [
{
"ade": "Refractory hypoglycemia",
"drug": "ciprofloxacin"
},
{
"ade": "Refractory hypoglycemia",
"drug": "glyburide"
}
] |
CONCLUSIONS: Cefazolin was a probable cause of this patient's leukopenia. | [
{
"ade": "leukopenia",
"drug": "Cefazolin"
}
] |
We report the case of a 40-year-old woman who developed fulminant hepatic failure and aplastic anaemia following a course of oral flucloxacillin. | [
{
"ade": "fulminant hepatic failure",
"drug": "flucloxacillin"
},
{
"ade": "aplastic anaemia",
"drug": "flucloxacillin"
}
] |
CONCLUSIONS: This case describes the clinically significant increase of INR in an elderly patient after adding a chemotherapy regimen of levamisole and 5-FU to a previous regimen of warfarin alone. | [
{
"ade": "increase of INR",
"drug": "levamisole"
},
{
"ade": "increase of INR",
"drug": "5-FU"
},
{
"ade": "increase of INR",
"drug": "warfarin"
}
] |
An objective causality assessment suggests that the JHR in our patient was probably related to penicillin. | [
{
"ade": "JHR",
"drug": "penicillin"
}
] |
Despite minimal short-term side effects and apparent efficacy, chronic treatment of MG with MM may be associated with increased risk of lymphoproliferative disorders. | [
{
"ade": "lymphoproliferative disorders",
"drug": "MM"
}
] |
After gastric-outlet obstruction was recognized in several infants who received prostaglandin E1, we studied the association between the drug and this complication. | [
{
"ade": "gastric-outlet obstruction",
"drug": "prostaglandin E1"
}
] |
A clinically atypical, neuropathologically verified case of Creutzfeldt-Jakob disease is described in a 32-year-old New Zealand woman with idiopathic hypopituitarism who had been treated in late adolescence (1970 to 1973) with human growth hormone processed from pooled cadaveric pituitary glands. | [
{
"ade": "Creutzfeldt-Jakob disease",
"drug": "human growth hormone"
}
] |
The occurrence of acute hepatitis is best known for ketoconazole. | [
{
"ade": "hepatitis",
"drug": "ketoconazole"
}
] |
INTRODUCTION: Although gefitinib used for the treatment of non-small-cell lung cancer is a well-known cause of interstitial lung disease (ILD), few case reports on erlotinib-induced ILD have been issued. | [
{
"ade": "interstitial lung disease",
"drug": "gefitinib"
},
{
"ade": "ILD",
"drug": "erlotinib"
},
{
"ade": "ILD",
"drug": "gefitinib"
}
] |
We concluded that the colonic ulcer and the sigmoidovesical fistula had been caused by the administration of calcium polystyrene sulfonate and sorbitol. | [
{
"ade": "colonic ulcer",
"drug": "calcium polystyrene sulfonate"
},
{
"ade": "sigmoidovesical fistula",
"drug": "calcium polystyrene sulfonate"
},
{
"ade": "sigmoidovesical fistula",
"drug": "sorbitol"
},
{
"ade": "colonic ulcer",
"drug": "sorbitol"
}
] |
Surprisingly, we found that three patients appeared to develop tardive OGC while taking clozapine. | [
{
"ade": "tardive OGC",
"drug": "clozapine"
}
] |
Clinicians should be aware of the signs and symptoms of neurotoxicity during treatment, as well as predisposing factors that put patients receiving methotrexate at risk for neurotoxic effects. | [
{
"ade": "neurotoxicity",
"drug": "methotrexate"
}
] |
Intrahepatic cholestasis and cutaneous bullae associated with glibenclamide therapy are described in a 61-year-old diabetic patient who presented wit hypoglycaemic coma. | [
{
"ade": "Intrahepatic cholestasis",
"drug": "glibenclamide"
},
{
"ade": "cutaneous bullae",
"drug": "glibenclamide"
}
] |
Methylphenidate-associated enuresis in attention deficit hyperactivity disorder. | [
{
"ade": "enuresis",
"drug": "Methylphenidate"
}
] |
We present a pediatric patient with leukemia and a severe, L-asparaginase-induced necrotizing pancreatitis, treated successfully with percutaneous drainage used to flush the infected necrotic parts. | [
{
"ade": "necrotizing pancreatitis",
"drug": "L-asparaginase"
}
] |
Based on our experience and on previously published data, serum ammonia levels appear to be indicated in all ED patients on valproic acid therapy who present with altered mental status. | [
{
"ade": "altered mental status",
"drug": "valproic acid"
}
] |
We report three cases of IFN beta induced hepatitis in MS and discuss the pathology findings and possible mechanisms of drug-induced liver injury. | [
{
"ade": "hepatitis",
"drug": "IFN beta"
},
{
"ade": "liver injury",
"drug": "IFN beta"
}
] |
Amphotericin B (AmB) is effective, but its use is limited by toxicity: renal impairment, anaemia, fever, malaise, and hypokalaemia are common. | [
{
"ade": "fever",
"drug": "Amphotericin B"
},
{
"ade": "malaise",
"drug": "AmB"
},
{
"ade": "anaemia",
"drug": "Amphotericin B"
},
{
"ade": "anaemia",
"drug": "AmB"
},
{
"ade": "malaise",
"drug": "Amphotericin B"
},
{
"ade": "renal impairment",
"drug": "Amphotericin B"
},
{
"ade": "hypokalaemia",
"drug": "AmB"
},
{
"ade": "renal impairment",
"drug": "AmB"
},
{
"ade": "fever",
"drug": "AmB"
},
{
"ade": "hypokalaemia",
"drug": "Amphotericin B"
}
] |
Thus any case of severe neutropenia occurring in a patient receiving olanzapine is alarming to clinicians. | [
{
"ade": "severe neutropenia",
"drug": "olanzapine"
}
] |
Three days after receiving intravitreal injection of bevacizumab (1.25 mg in 0.1 ml), he developed acute vision loss and change of consciousness. | [
{
"ade": "acute vision loss",
"drug": "bevacizumab"
},
{
"ade": "change of consciousness",
"drug": "bevacizumab"
}
] |
CONTEXT: Previous investigators have reported discrepancies between hematologic, marrow morphologic, and cytogenetic responses to imatinib mesylate among patients with chronic myeloid leukemia (CML). | [
{
"ade": "discrepancies between hematologic, marrow morphologic, and cytogenetic responses",
"drug": "imatinib mesylate"
}
] |
Bleomycin induced hyperpigmentation with yolk sac tumor. | [
{
"ade": "hyperpigmentation",
"drug": "Bleomycin"
}
] |
DISCUSSION: Methotrexate-induced papular eruption is rarely reported shortly after beginning methotrexate therapy in patients with acute exacerbation of collagen vascular diseases. | [
{
"ade": "papular eruption",
"drug": "Methotrexate"
}
] |
We report an additional case of isotretinoin teratogenicity in which the patient had agenesis of the cerebellar vermis, multiple leptomeningeal neuroglial heterotopias, hydrocephalus, and abnormalities of the corticospinal tracts. | [
{
"ade": "teratogenicity",
"drug": "isotretinoin"
},
{
"ade": "agenesis of the cerebellar vermis",
"drug": "isotretinoin"
},
{
"ade": "multiple leptomeningeal neuroglial heterotopias",
"drug": "isotretinoin"
},
{
"ade": "hydrocephalus",
"drug": "isotretinoin"
},
{
"ade": "abnormalities of the corticospinal tracts",
"drug": "isotretinoin"
}
] |
Two renal transplant patients developed anemia during treatment of hypertension with enalapril medication. | [
{
"ade": "anemia",
"drug": "enalapril"
}
] |
Pseudoephedrine-induced hemorrhage associated with a cerebral vascular malformation. | [
{
"ade": "hemorrhage",
"drug": "Pseudoephedrine"
},
{
"ade": "cerebral vascular malformation",
"drug": "Pseudoephedrine"
}
] |
CONCLUSIONS: Sustained-release verapamil is thought to be the cause of the asthma attack in this patient because she was not taking any other preparations; the symptoms started with the administration of sustained-release verapamil and were relieved after its discontinuation. | [
{
"ade": "asthma attack",
"drug": "verapamil"
}
] |
We hypothesize that capecitabine-induced headache is vascular in nature. | [
{
"ade": "headache",
"drug": "capecitabine"
}
] |
A case of aseptic pleuropericarditis in a patient with chronic plaque psoriasis under methotrexate therapy. | [
{
"ade": "aseptic pleuropericarditis",
"drug": "methotrexate"
}
] |
A 79-year-old man with ischemic heart disease, chronic atrial fibrillation, chronic renal failure, hypothyroidism, and gout arthritis was hospitalized because of fatigue, myalgia, and leg weakness, shortly after starting treatment with colchicine. | [
{
"ade": "leg weakness",
"drug": "colchicine"
},
{
"ade": "fatigue",
"drug": "colchicine"
},
{
"ade": "myalgia",
"drug": "colchicine"
}
] |
Isotretinoin, a drug used for the treatment of acne, has been shown to have teratogenic effects. | [
{
"ade": "teratogenic effects",
"drug": "Isotretinoin"
}
] |
We describe two patients with aspergillus arthritis of the knee joint following fludarabine-based non-myeloablative stem cell transplantation. | [
{
"ade": "aspergillus arthritis of the knee joint",
"drug": "fludarabine"
}
] |
Since the thrombocyte count started to increase immediately after initiation and dropped immediately after discontinuation of ciprofloxacin and tazobactam/piperacillin and all other drugs were discontinued already before or were started after the nadir of the thrombocyte count, these two antibiotics were regarded causative. | [
{
"ade": "thrombocyte count started to increase",
"drug": "piperacillin"
},
{
"ade": "thrombocyte count started to increase",
"drug": "ciprofloxacin"
},
{
"ade": "thrombocyte count started to increase",
"drug": "tazobactam"
}
] |
A mentally retarded 23-year-old woman with myoclonic astatic epilepsy developed an abnormal posture of extreme forward flexion, called camptocormia, during valproate monotherapy. | [
{
"ade": "abnormal posture of extreme forward flexion",
"drug": "valproate"
},
{
"ade": "camptocormia",
"drug": "valproate"
}
] |
Transient hemiparesis caused by phenytoin toxicity. | [
{
"ade": "Transient hemiparesis",
"drug": "phenytoin"
}
] |
A 65-year-old woman with bipolar disorder and complicated cardiovascular disease who was on maintenance lithium therapy developed a movement disorder following high doses of trazodone for treatment of an acute depression. | [
{
"ade": "movement disorder",
"drug": "trazodone"
},
{
"ade": "movement disorder",
"drug": "lithium"
}
] |
After abstinence from oolong tea his delirium resolved. | [
{
"ade": "delirium",
"drug": "oolong tea"
}
] |
Hypernatraemia induced by sodium polystyrene sulphonate (Kayexalate) in two extremely low birth weight newborns. | [
{
"ade": "Hypernatraemia",
"drug": "Kayexalate"
},
{
"ade": "Hypernatraemia",
"drug": "sodium polystyrene sulphonate"
}
] |
Reversible sclerotic changes of lumbar spine and femur due to long-term oral isotretinoin therapy. | [
{
"ade": "sclerotic changes of lumbar spine and femur",
"drug": "isotretinoin"
}
] |
To our knowledge, our report is one of the first on shock and angio-oedema from irbesartan. | [
{
"ade": "shock",
"drug": "irbesartan"
},
{
"ade": "angio-oedema",
"drug": "irbesartan"
}
] |
CONCLUSIONS: This is the second case report that describes gemcitabine-induced radiation recall in rectus abdominus muscles after gemcitabine-based radiation therapy. | [
{
"ade": "radiation recall",
"drug": "gemcitabine"
}
] |
Amiodarone hydrochloride, a new antiarrhythmic agent, has been associated with pulmonary toxicity characterized by cough, dyspnea and diffuse pulmonary infiltrates. | [
{
"ade": "diffuse pulmonary infiltrates",
"drug": "Amiodarone hydrochloride"
},
{
"ade": "dyspnea",
"drug": "Amiodarone hydrochloride"
},
{
"ade": "pulmonary toxicity",
"drug": "Amiodarone hydrochloride"
},
{
"ade": "cough",
"drug": "Amiodarone hydrochloride"
}
] |
OBJECTIVE: To test the hypothesis that tumor necrosis factor (TNF)-alpha may mediate the loss and the dedifferentiation of subcutaneous fat tissue in the insulin-induced lipoatrophies of a diabetic patient who presented extensive lesions. | [
{
"ade": "lipoatrophies",
"drug": "insulin"
}
] |
Two cases of polymorphic ventricular tachycardia induced by the administration of verapamil against paroxysmal supraventricular tachycardia. | [
{
"ade": "polymorphic ventricular tachycardia",
"drug": "verapamil"
}
] |
We describe four patients who had seizures while receiving ofloxacin; no other causes were evident. | [
{
"ade": "seizures",
"drug": "ofloxacin"
}
] |
A patient that received methadone for cancer-associated pain developed myoclonus as a side effect. | [
{
"ade": "myoclonus",
"drug": "methadone"
}
] |
Isonicotinic acid hydrazide induced anagen effluvium and associated lichenoid eruption. | [
{
"ade": "lichenoid eruption",
"drug": "Isonicotinic acid hydrazide"
},
{
"ade": "anagen effluvium",
"drug": "Isonicotinic acid hydrazide"
}
] |
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