unprocessed
stringlengths 304
936
| processed
stringlengths 4
1.01k
|
|---|---|
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: We investigated the effects of clentiazem , a 1 , 5 - benzothiazepine calcium antagonist , on epinephrine - induced cardiomyopathy in rats .
### Output Text: | We investigated the effects of <span class="chemical">clentiazem</span> , a <span class="chemical">1 , 5 - benzothiazepine</span> <span class="chemical">calcium</span> antagonist , on <span class="chemical">epinephrine</span> - induced cardiomyopathy in rats . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: With 2 - week chronic epinephrine infusion , 16 of 30 rats died within 4 days , and severe ischemic lesions and fibrosis of the left ventricles were observed .
### Output Text: | With 2 - week chronic <span class="chemical">epinephrine</span> infusion , 16 of 30 rats died within 4 days , and severe ischemic lesions and fibrosis of the left ventricles were observed . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: In epinephrine - treated rats , left atrial and left ventricular papillary muscle contractile responses to isoproterenol were reduced , but responses to calcium were normal or enhanced compared to controls .
### Output Text: | In <span class="chemical">epinephrine</span> - treated rats , left atrial and left ventricular papillary muscle contractile responses to <span class="chemical">isoproterenol</span> were reduced , but responses to <span class="chemical">calcium</span> were normal or enhanced compared to controls . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Left ventricular alpha and beta adrenoceptor densities were also reduced compared to controls .
### Output Text: | Left ventricular alpha and beta adrenoceptor densities were also reduced compared to controls . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Treatment with clentiazem prevented epinephrine - induced death ( P < . 05 ) , and attenuated the ventricular ischemic lesions and fibrosis , in a dose - dependent manner .
### Output Text: | Treatment with <span class="chemical">clentiazem</span> prevented <span class="chemical">epinephrine</span> - induced death ( P < . 05 ) , and attenuated the ventricular ischemic lesions and fibrosis , in a dose - dependent manner . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Left atrial and left ventricular papillary muscle contractile responses to isoproterenol were reduced compared to controls in groups treated with clentiazem alone , but combined with epinephrine , clentiazem restored left atrial responses and enhanced left ventricular papillary responses to isoproterenol .
### Output Text: | Left atrial and left ventricular papillary muscle contractile responses to <span class="chemical">isoproterenol</span> were reduced compared to controls in groups treated with <span class="chemical">clentiazem</span> alone , but combined with <span class="chemical">epinephrine</span> , <span class="chemical">clentiazem</span> restored left atrial responses and enhanced left ventricular papillary responses to <span class="chemical">isoproterenol</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: On the other hand clentiazem did not prevent epinephrine - induced down - regulation of alpha and beta adrenoceptors .
### Output Text: | On the other hand <span class="chemical">clentiazem</span> did not prevent <span class="chemical">epinephrine</span> - induced down - regulation of alpha and beta adrenoceptors . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Interestingly , clentiazem , infused alone , resulted in decreased adrenergic receptor densities in the left ventricle .
### Output Text: | Interestingly , <span class="chemical">clentiazem</span> , infused alone , resulted in decreased adrenergic receptor densities in the left ventricle . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Clentiazem also did not prevent the enhanced responses to calcium seen in the epinephrine - treated animals , although the high dose of clentiazem partially attenuated the maximal response to calcium compared to epinephrine - treated animals .
### Output Text: | <span class="chemical">Clentiazem</span> also did not prevent the enhanced responses to <span class="chemical">calcium</span> seen in the <span class="chemical">epinephrine</span> - treated animals , although the high dose of <span class="chemical">clentiazem</span> partially attenuated the maximal response to <span class="chemical">calcium</span> compared to <span class="chemical">epinephrine</span> - treated animals . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: In conclusion , clentiazem attenuated epinephrine - induced cardiac injury , possibly through its effect on the adrenergic pathway .
### Output Text: | In conclusion , <span class="chemical">clentiazem</span> attenuated <span class="chemical">epinephrine</span> - induced cardiac injury , possibly through its effect on the adrenergic pathway . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Kaliuretic effect of L - dopa treatment in parkinsonian patients .
### Output Text: | Kaliuretic effect of <span class="chemical">L - dopa</span> treatment in parkinsonian patients . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Hypokalemia , sometimes severe , was observed in some L - dopa - treated parkinsonian patients .
### Output Text: | Hypokalemia , sometimes severe , was observed in some <span class="chemical">L - dopa</span> - treated parkinsonian patients . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The influence of L - dopa on the renal excretion of potassium was studied in 3 patients with hypokalemia and in 5 normokalemic patients by determination of renal plasma flow , glomerular filtration rate , plasma concentration of potassium and sodium as well as urinary excretion of potassium , sodium and aldosterone .
### Output Text: | The influence of <span class="chemical">L - dopa</span> on the renal excretion of <span class="chemical">potassium</span> was studied in 3 patients with hypokalemia and in 5 normokalemic patients by determination of renal plasma flow , glomerular filtration rate , plasma concentration of <span class="chemical">potassium</span> and <span class="chemical">sodium</span> as well as urinary excretion of <span class="chemical">potassium</span> , <span class="chemical">sodium</span> and <span class="chemical">aldosterone</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: L - Dopa intake was found to cause an increased excretion of potassium , and sometimes also of sodium , in the hypokalemic but not in the normokalemic patients .
### Output Text: | <span class="chemical">L - Dopa</span> intake was found to cause an increased excretion of <span class="chemical">potassium</span> , and sometimes also of <span class="chemical">sodium</span> , in the hypokalemic but not in the normokalemic patients . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: This effect on the renal function could be prohibited by the administration of a peripheral dopa decarbodylase inhibitor .
### Output Text: | This effect on the renal function could be prohibited by the administration of a peripheral dopa decarbodylase inhibitor . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: It is not known why this effect occurred in some individuals but not in others , but our results indicate a correlation between aldosterone production and this renal effect of L - dopa .
### Output Text: | It is not known why this effect occurred in some individuals but not in others , but our results indicate a correlation between <span class="chemical">aldosterone</span> production and this renal effect of <span class="chemical">L - dopa</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Cocaine induced myocardial ischemia .
### Output Text: | <span class="chemical">Cocaine</span> induced myocardial ischemia . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: We report a case of myocardial ischemia induced by cocaine .
### Output Text: | We report a case of myocardial ischemia induced by <span class="chemical">cocaine</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The ischemia probably induced by coronary artery spasm was reversed by nitroglycerin and calcium blocking agents .
### Output Text: | The ischemia probably induced by coronary artery spasm was reversed by <span class="chemical">nitroglycerin</span> and <span class="chemical">calcium</span> blocking agents . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Doxorubicin - induced cardiotoxicity monitored by ECG in freely moving mice .
### Output Text: | <span class="chemical">Doxorubicin</span> - induced cardiotoxicity monitored by ECG in freely moving mice . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: A new model to test potential protectors .
### Output Text: | A new model to test potential protectors . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: In laboratory animals , histology is most commonly used to study doxorubicin - induced cardiotoxicity .
### Output Text: | In laboratory animals , histology is most commonly used to study <span class="chemical">doxorubicin</span> - induced cardiotoxicity . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: However , for monitoring during treatment , large numbers of animals are needed .
### Output Text: | However , for monitoring during treatment , large numbers of animals are needed . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Recently we developed a new method to measure ECG values in freely moving mice by telemetry .
### Output Text: | Recently we developed a new method to measure ECG values in freely moving mice by telemetry . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: With this model we investigated the effect of chronic doxorubicin administration on the ECG of freely moving BALB / c mice and the efficacy of ICRF - 187 as a protective agent .
### Output Text: | With this model we investigated the effect of chronic <span class="chemical">doxorubicin</span> administration on the ECG of freely moving BALB / c mice and the efficacy of <span class="chemical">ICRF - 187</span> as a protective agent . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The ST interval significantly widened from 15 . 0 + / - 1 . 5 to 56 . 8 + / - 11 . 8 ms in week 10 ( 7 weekly doses of 4 mg / kg doxorubicin given i . v . plus 3 weeks of observation ) .
### Output Text: | The ST interval significantly widened from 15 . 0 + / - 1 . 5 to 56 . 8 + / - 11 . 8 ms in week 10 ( 7 weekly doses of 4 mg / kg <span class="chemical">doxorubicin</span> given i . v . plus 3 weeks of observation ) . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The ECG of the control animals did not change during the entire study .
### Output Text: | The ECG of the control animals did not change during the entire study . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: After sacrifice the hearts of doxorubicin - treated animals were enlarged and the atria were hypertrophic .
### Output Text: | After sacrifice the hearts of <span class="chemical">doxorubicin</span> - treated animals were enlarged and the atria were hypertrophic . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: As this schedule exerted more toxicity than needed to investigate protective agents , the protection of ICRF - 187 was determined using a dose schedule with lower general toxicity ( 6 weekly doses of 4 mg / kg doxorubicin given i . v . plus 2 weeks of observation ) .
### Output Text: | As this schedule exerted more toxicity than needed to investigate protective agents , the protection of <span class="chemical">ICRF - 187</span> was determined using a dose schedule with lower general toxicity ( 6 weekly doses of 4 mg / kg <span class="chemical">doxorubicin</span> given i . v . plus 2 weeks of observation ) . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: On this schedule , the animals ' hearts appeared normal after sacrifice and ICRF - 187 ( 50 mg / kg given i . p . 1 h before doxorubicin ) provided almost full protection .
### Output Text: | On this schedule , the animals ' hearts appeared normal after sacrifice and <span class="chemical">ICRF - 187</span> ( 50 mg / kg given i . p . 1 h before <span class="chemical">doxorubicin</span> ) provided almost full protection . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: These data were confirmed by histology .
### Output Text: | These data were confirmed by histology . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The results indicate that this new model is very sensitive and enables monitoring of the development of cardiotoxicity with time .
### Output Text: | The results indicate that this new model is very sensitive and enables monitoring of the development of cardiotoxicity with time . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: These findings result in a model that allows the testing of protectors against doxorubicin - induced cardiotoxicity as demonstrated by the protection provided by ICRF - 187 .
### Output Text: | These findings result in a model that allows the testing of protectors against <span class="chemical">doxorubicin</span> - induced cardiotoxicity as demonstrated by the protection provided by <span class="chemical">ICRF - 187</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Epinephrine dysrhythmogenicity is not enhanced by subtoxic bupivacaine in dogs .
### Output Text: | <span class="chemical">Epinephrine</span> dysrhythmogenicity is not enhanced by subtoxic <span class="chemical">bupivacaine</span> in dogs . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Since bupivacaine and epinephrine may both precipitate dysrhythmias , circulating bupivacaine during regional anesthesia could potentiate dysrhythmogenic effects of epinephrine .
### Output Text: | Since <span class="chemical">bupivacaine</span> and <span class="chemical">epinephrine</span> may both precipitate dysrhythmias , circulating <span class="chemical">bupivacaine</span> during regional anesthesia could potentiate dysrhythmogenic effects of <span class="chemical">epinephrine</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: We therefore examined whether bupivacaine alters the dysrhythmogenicity of subsequent administration of epinephrine in conscious , healthy dogs and in anesthetized dogs with myocardial infarction .
### Output Text: | We therefore examined whether <span class="chemical">bupivacaine</span> alters the dysrhythmogenicity of subsequent administration of <span class="chemical">epinephrine</span> in conscious , healthy dogs and in anesthetized dogs with myocardial infarction . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Forty - one conscious dogs received 10 micrograms . kg - 1 . min - 1 epinephrine .
### Output Text: | Forty - one conscious dogs received 10 micrograms . kg - 1 . min - 1 <span class="chemical">epinephrine</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Seventeen animals responded with ventricular tachycardia ( VT ) within 3 min .
### Output Text: | Seventeen animals responded with ventricular tachycardia ( VT ) within 3 min . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: After 3 h , these responders randomly received 1 or 2 mg / kg bupivacaine or saline over 5 min , followed by 10 micrograms . kg - 1 . min - 1 epinephrine .
### Output Text: | After 3 h , these responders randomly received 1 or 2 mg / kg <span class="chemical">bupivacaine</span> or saline over 5 min , followed by 10 micrograms . kg - 1 . min - 1 <span class="chemical">epinephrine</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: In the bupivacaine groups , epinephrine caused fewer prodysrhythmic effects than without bupivacaine .
### Output Text: | In the <span class="chemical">bupivacaine</span> groups , <span class="chemical">epinephrine</span> caused fewer prodysrhythmic effects than without <span class="chemical">bupivacaine</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: VT appeared in fewer dogs and at a later time , and there were more sinoatrial beats and less ectopies .
### Output Text: | VT appeared in fewer dogs and at a later time , and there were more sinoatrial beats and less ectopies . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Epinephrine shortened QT less after bupivacaine than in control animals .
### Output Text: | <span class="chemical">Epinephrine</span> shortened QT less after <span class="chemical">bupivacaine</span> than in control animals . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: One day after experimental myocardial infarction , six additional halothane - anesthetized dogs received 4 micrograms . kg - 1 . min - 1 epinephrine until VT appeared .
### Output Text: | One day after experimental myocardial infarction , six additional <span class="chemical">halothane</span> - anesthetized dogs received 4 micrograms . kg - 1 . min - 1 <span class="chemical">epinephrine</span> until VT appeared . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: After 45 min , 1 mg / kg bupivacaine was injected over 5 min , again followed by 4 micrograms . kg - 1 . min - 1 epinephrine .
### Output Text: | After 45 min , 1 mg / kg <span class="chemical">bupivacaine</span> was injected over 5 min , again followed by 4 micrograms . kg - 1 . min - 1 <span class="chemical">epinephrine</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: In these dogs , the prodysrhythmic response to epinephrine was also mitigated by preceding bupivacaine .
### Output Text: | In these dogs , the prodysrhythmic response to <span class="chemical">epinephrine</span> was also mitigated by preceding <span class="chemical">bupivacaine</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Bupivacaine antagonizes epinephrine dysrhythmogenicity in conscious dogs susceptible to VT and in anesthetized dogs with spontaneous postinfarct dysrhythmias .
### Output Text: | <span class="chemical">Bupivacaine</span> antagonizes <span class="chemical">epinephrine</span> dysrhythmogenicity in conscious dogs susceptible to VT and in anesthetized dogs with spontaneous postinfarct dysrhythmias . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: There is no evidence that systemic subtoxic bupivacaine administration enhances the dysrhythmogenicity of subsequent epinephrine .
### Output Text: | There is no evidence that systemic subtoxic <span class="chemical">bupivacaine</span> administration enhances the dysrhythmogenicity of subsequent <span class="chemical">epinephrine</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Milk - alkali syndrome induced by 1 , 25 ( OH ) 2D in a patient with hypoparathyroidism .
### Output Text: | Milk - alkali syndrome induced by <span class="chemical">1 , 25 ( OH ) 2D</span> in a patient with hypoparathyroidism . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Milk - alkali syndrome was first described 70 years ago in the context of the treatment of peptic ulcer disease with large amounts of calcium and alkali .
### Output Text: | Milk - alkali syndrome was first described 70 years ago in the context of the treatment of peptic ulcer disease with large amounts of <span class="chemical">calcium</span> and <span class="chemical">alkali</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Although with current ulcer therapy ( H - 2 blockers , omeprazole , and sucralfate ) , the frequency of milk - alkali syndrome has decreased significantly , the classic triad of hypercalcemia , alkalosis , and renal impairment remains the hallmark of the syndrome .
### Output Text: | Although with current ulcer therapy ( H - 2 blockers , <span class="chemical">omeprazole</span> , and <span class="chemical">sucralfate</span> ) , the frequency of milk - alkali syndrome has decreased significantly , the classic triad of hypercalcemia , alkalosis , and renal impairment remains the hallmark of the syndrome . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Milk - alkali syndrome can present serious and occasionally life - threatening illness unless diagnosed and treated appropriately .
### Output Text: | Milk - alkali syndrome can present serious and occasionally life - threatening illness unless diagnosed and treated appropriately . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: This article presents a patient with hypoparathyroidism who was treated with calcium carbonate and calcitriol resulting in two admissions to the hospital for milk - alkali syndrome .
### Output Text: | This article presents a patient with hypoparathyroidism who was treated with <span class="chemical">calcium carbonate</span> and <span class="chemical">calcitriol</span> resulting in two admissions to the hospital for milk - alkali syndrome . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The patient was successfully treated with intravenous pamidronate on his first admission and with hydrocortisone on the second .
### Output Text: | The patient was successfully treated with intravenous <span class="chemical">pamidronate</span> on his first admission and with <span class="chemical">hydrocortisone</span> on the second . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: This illustrates intravenous pamidronate as a valuable therapeutic tool when milk - alkali syndrome presents as hypercalcemic emergency .
### Output Text: | This illustrates intravenous <span class="chemical">pamidronate</span> as a valuable therapeutic tool when milk - alkali syndrome presents as hypercalcemic emergency . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Famotidine - associated delirium .
### Output Text: | <span class="chemical">Famotidine</span> - associated delirium . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: A series of six cases .
### Output Text: | A series of six cases . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Famotidine is a histamine H2 - receptor antagonist used in inpatient settings for prevention of stress ulcers and is showing increasing popularity because of its low cost .
### Output Text: | <span class="chemical">Famotidine</span> is a histamine H2 - receptor antagonist used in inpatient settings for prevention of stress ulcers and is showing increasing popularity because of its low cost . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Although all of the currently available H2 - receptor antagonists have shown the propensity to cause delirium , only two previously reported cases have been associated with famotidine .
### Output Text: | Although all of the currently available H2 - receptor antagonists have shown the propensity to cause delirium , only two previously reported cases have been associated with <span class="chemical">famotidine</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The authors report on six cases of famotidine - associated delirium in hospitalized patients who cleared completely upon removal of famotidine .
### Output Text: | The authors report on six cases of <span class="chemical">famotidine</span> - associated delirium in hospitalized patients who cleared completely upon removal of <span class="chemical">famotidine</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The pharmacokinetics of famotidine are reviewed , with no change in its metabolism in the elderly population seen .
### Output Text: | The pharmacokinetics of <span class="chemical">famotidine</span> are reviewed , with no change in its metabolism in the elderly population seen . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The implications of using famotidine in elderly persons are discussed .
### Output Text: | The implications of using <span class="chemical">famotidine</span> in elderly persons are discussed . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Encephalopathy during amitriptyline therapy : are neuroleptic malignant syndrome and serotonin syndrome spectrum disorders ?
### Output Text: | Encephalopathy during <span class="chemical">amitriptyline</span> therapy : are neuroleptic malignant syndrome and serotonin syndrome spectrum disorders ? |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: This report describes a case of encephalopathy developed in the course of amitriptyline therapy , during a remission of unipolar depression .
### Output Text: | This report describes a case of encephalopathy developed in the course of <span class="chemical">amitriptyline</span> therapy , during a remission of unipolar depression . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: This patient could have been diagnosed as having either neuroleptic malignant syndrome ( NMS ) or serotonin syndrome ( SS ) .
### Output Text: | This patient could have been diagnosed as having either neuroleptic malignant syndrome ( NMS ) or serotonin syndrome ( SS ) . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The major determinant of the symptoms may have been dopamine / serotonin imbalance in the central nervous system .
### Output Text: | The major determinant of the symptoms may have been <span class="chemical">dopamine</span> / <span class="chemical">serotonin</span> imbalance in the central nervous system . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The NMS - like encephalopathy that develops in association with the use of antidepressants indicates that NMS and SS are spectrum disorders induced by drugs with both antidopaminergic and serotonergic effects .
### Output Text: | The NMS - like encephalopathy that develops in association with the use of antidepressants indicates that NMS and SS are spectrum disorders induced by drugs with both antidopaminergic and serotonergic effects . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Genetic separation of tumor growth and hemorrhagic phenotypes in an estrogen - induced tumor .
### Output Text: | Genetic separation of tumor growth and hemorrhagic phenotypes in an <span class="chemical">estrogen</span> - induced tumor . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Chronic administration of estrogen to the Fischer 344 ( F344 ) rat induces growth of large , hemorrhagic pituitary tumors .
### Output Text: | Chronic administration of <span class="chemical">estrogen</span> to the Fischer 344 ( F344 ) rat induces growth of large , hemorrhagic pituitary tumors . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Ten weeks of diethylstilbestrol ( DES ) treatment caused female F344 rat pituitaries to grow to an average of 109 . 2 + / - 6 . 3 mg ( mean + / - SE ) versus 11 . 3 + / - 1 . 4 mg for untreated rats , and to become highly hemorrhagic .
### Output Text: | Ten weeks of <span class="chemical">diethylstilbestrol</span> ( <span class="chemical">DES</span> ) treatment caused female F344 rat pituitaries to grow to an average of 109 . 2 + / - 6 . 3 mg ( mean + / - SE ) versus 11 . 3 + / - 1 . 4 mg for untreated rats , and to become highly hemorrhagic . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The same DES treatment produced no significant growth ( 8 . 9 + / - 0 . 5 mg for treated females versus 8 . 7 + / - 1 . 1 for untreated females ) or morphological changes in Brown Norway ( BN ) rat pituitaries .
### Output Text: | The same <span class="chemical">DES</span> treatment produced no significant growth ( 8 . 9 + / - 0 . 5 mg for treated females versus 8 . 7 + / - 1 . 1 for untreated females ) or morphological changes in Brown Norway ( BN ) rat pituitaries . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: An F1 hybrid of F344 and BN exhibited significant pituitary growth after 10 weeks of DES treatment with an average mass of 26 . 3 + / - 0 . 7 mg compared with 8 . 6 + / - 0 . 9 mg for untreated rats .
### Output Text: | An F1 hybrid of F344 and BN exhibited significant pituitary growth after 10 weeks of <span class="chemical">DES</span> treatment with an average mass of 26 . 3 + / - 0 . 7 mg compared with 8 . 6 + / - 0 . 9 mg for untreated rats . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Surprisingly , the F1 hybrid tumors were not hemorrhagic and had hemoglobin content and outward appearance identical to that of BN .
### Output Text: | Surprisingly , the F1 hybrid tumors were not hemorrhagic and had hemoglobin content and outward appearance identical to that of BN . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Expression of both growth and morphological changes is due to multiple genes .
### Output Text: | Expression of both growth and morphological changes is due to multiple genes . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: However , while DES - induced pituitary growth exhibited quantitative , additive inheritance , the hemorrhagic phenotype exhibited recessive , epistatic inheritance .
### Output Text: | However , while <span class="chemical">DES</span> - induced pituitary growth exhibited quantitative , additive inheritance , the hemorrhagic phenotype exhibited recessive , epistatic inheritance . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Only 5 of the 160 F2 pituitaries exhibited the hemorrhagic phenotype ; 36 of the 160 F2 pituitaries were in the F344 range of mass , but 31 of these were not hemorrhagic , indicating that the hemorrhagic phenotype is not merely a consequence of extensive growth .
### Output Text: | Only 5 of the 160 F2 pituitaries exhibited the hemorrhagic phenotype ; 36 of the 160 F2 pituitaries were in the F344 range of mass , but 31 of these were not hemorrhagic , indicating that the hemorrhagic phenotype is not merely a consequence of extensive growth . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The hemorrhagic F2 pituitaries were all among the most massive , indicating that some of the genes regulate both phenotypes .
### Output Text: | The hemorrhagic F2 pituitaries were all among the most massive , indicating that some of the genes regulate both phenotypes . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Increased expression of neuronal nitric oxide synthase in bladder afferent pathways following chronic bladder irritation .
### Output Text: | Increased expression of neuronal <span class="chemical">nitric oxide</span> synthase in bladder afferent pathways following chronic bladder irritation . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Immunocytochemical techniques were used to examine alterations in the expression of neuronal nitric oxide synthase ( NOS ) in bladder pathways following acute and chronic irritation of the urinary tract of the rat .
### Output Text: | Immunocytochemical techniques were used to examine alterations in the expression of neuronal <span class="chemical">nitric oxide</span> synthase ( NOS ) in bladder pathways following acute and chronic irritation of the urinary tract of the rat . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Chemical cystitis was induced by cyclophosphamide ( CYP ) which is metabolized to acrolein , an irritant eliminated in the urine .
### Output Text: | Chemical cystitis was induced by <span class="chemical">cyclophosphamide</span> ( <span class="chemical">CYP</span> ) which is metabolized to <span class="chemical">acrolein</span> , an irritant eliminated in the urine . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Injection of CYP ( n = 10 , 75 mg / kg , i . p . ) 2 hours prior to perfusion ( acute treatment ) of the animals increased Fos - immunoreactivity ( IR ) in neurons in the dorsal commissure , dorsal horn , and autonomic regions of spinal segments ( L1 - L2 and L6 - S1 ) which receive afferent inputs from the bladder , urethra , and ureter .
### Output Text: | Injection of <span class="chemical">CYP</span> ( n = 10 , 75 mg / kg , i . p . ) 2 hours prior to perfusion ( acute treatment ) of the animals increased Fos - immunoreactivity ( IR ) in neurons in the dorsal commissure , dorsal horn , and autonomic regions of spinal segments ( L1 - L2 and L6 - S1 ) which receive afferent inputs from the bladder , urethra , and ureter . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Fos - IR in the spinal cord was not changed in rats receiving chronic CYP treatment ( n = 15 , 75 mg / kg , i . p . , every 3rd day for 2 weeks ) .
### Output Text: | Fos - IR in the spinal cord was not changed in rats receiving chronic <span class="chemical">CYP</span> treatment ( n = 15 , 75 mg / kg , i . p . , every 3rd day for 2 weeks ) . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: In control animals and in animals treated acutely with CYP , only small numbers of NOS - IR cells ( 0 . 5 - 0 . 7 cell profiles / sections ) were detected in the L6 - S1 dorsal root ganglia ( DRG ) .
### Output Text: | In control animals and in animals treated acutely with <span class="chemical">CYP</span> , only small numbers of NOS - IR cells ( 0 . 5 - 0 . 7 cell profiles / sections ) were detected in the L6 - S1 dorsal root ganglia ( DRG ) . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Chronic CYP administration significantly ( P < or = . 002 ) increased bladder weight by 60 % and increased ( 7 - to 11 - fold ) the numbers of NOS - immunoreactive ( IR ) afferent neurons in the L6 - S1 DRG .
### Output Text: | Chronic <span class="chemical">CYP</span> administration significantly ( P < or = . 002 ) increased bladder weight by 60 % and increased ( 7 - to 11 - fold ) the numbers of NOS - immunoreactive ( IR ) afferent neurons in the L6 - S1 DRG . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: A small increase ( 1 . 5 - fold ) also occurred in the L1 DRG , but no change was detected in the L2 and L5 DRG .
### Output Text: | A small increase ( 1 . 5 - fold ) also occurred in the L1 DRG , but no change was detected in the L2 and L5 DRG . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Bladder afferent cells in the L6 - S1 DRG labeled by Fluorogold ( 40 microliters ) injected into the bladder wall did not exhibit NOS - IR in control animals ; however , following chronic CYP administration , a significant percentage of bladder afferent neurons were NOS - IR : L6 ( 19 . 8 + / - 4 . 6 % ) and S1 ( 25 . 3 + / - 2 . 9 % ) .
### Output Text: | Bladder afferent cells in the L6 - S1 DRG labeled by Fluorogold ( 40 microliters ) injected into the bladder wall did not exhibit NOS - IR in control animals ; however , following chronic <span class="chemical">CYP</span> administration , a significant percentage of bladder afferent neurons were NOS - IR : L6 ( 19 . 8 + / - 4 . 6 % ) and S1 ( 25 . 3 + / - 2 . 9 % ) . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: These results indicate that neuronal gene expression in visceral sensory pathways can be upregulated by chemical irritation of afferent receptors in the urinary tract and / or that pathological changes in the urinary tract can initiate chemical signals that alter the chemical properties of visceral afferent neurons .
### Output Text: | These results indicate that neuronal gene expression in visceral sensory pathways can be upregulated by chemical irritation of afferent receptors in the urinary tract and / or that pathological changes in the urinary tract can initiate chemical signals that alter the chemical properties of visceral afferent neurons . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Effects of a new calcium antagonist , CD - 832 , on isoproterenol - induced myocardial ischemia in dogs with partial coronary stenosis .
### Output Text: | Effects of a new <span class="chemical">calcium</span> antagonist , <span class="chemical">CD - 832</span> , on <span class="chemical">isoproterenol</span> - induced myocardial ischemia in dogs with partial coronary stenosis . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Effects of CD - 832 on isoproterenol ( ISO ) - induced myocardial ischemia were studied in dogs with partial coronary stenosis of the left circumflex coronary artery and findings were compared with those for nifedipine or diltiazem .
### Output Text: | Effects of <span class="chemical">CD - 832</span> on <span class="chemical">isoproterenol</span> ( <span class="chemical">ISO</span> ) - induced myocardial ischemia were studied in dogs with partial coronary stenosis of the left circumflex coronary artery and findings were compared with those for <span class="chemical">nifedipine</span> or <span class="chemical">diltiazem</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: In the presence of coronary artery stenosis , 3 - min periods of intracoronary ISO infusion ( 10 ng / kg / min ) increased heart rate and maximal rate of left ventricular pressure rise , which resulted in a decrease in percentage segmental shortening and ST - segment elevation of the epicardial electrocardiogram .
### Output Text: | In the presence of coronary artery stenosis , 3 - min periods of intracoronary <span class="chemical">ISO</span> infusion ( 10 ng / kg / min ) increased heart rate and maximal rate of left ventricular pressure rise , which resulted in a decrease in percentage segmental shortening and ST - segment elevation of the epicardial electrocardiogram . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: After the control ISO infusion with stenosis was performed , equihypotensive doses of CD - 832 ( 3 and 10 micrograms / kg / min , n = 7 ) , nifedipine ( 1 and 3 micrograms / kg / min , n = 9 ) or diltiazem ( 10 and 30 micrograms / kg / min , n = 7 ) were infused 5 min before and during the second and third ISO infusion .
### Output Text: | After the control <span class="chemical">ISO</span> infusion with stenosis was performed , equihypotensive doses of <span class="chemical">CD - 832</span> ( 3 and 10 micrograms / kg / min , n = 7 ) , <span class="chemical">nifedipine</span> ( 1 and 3 micrograms / kg / min , n = 9 ) or <span class="chemical">diltiazem</span> ( 10 and 30 micrograms / kg / min , n = 7 ) were infused 5 min before and during the second and third <span class="chemical">ISO</span> infusion . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Both CD - 832 and diltiazem , but not nifedipine , significantly reduced the increase in heart rate induced by ISO infusion .
### Output Text: | Both <span class="chemical">CD - 832</span> and <span class="chemical">diltiazem</span> , but not <span class="chemical">nifedipine</span> , significantly reduced the increase in heart rate induced by <span class="chemical">ISO</span> infusion . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: In contrast to nifedipine , CD - 832 ( 10 micrograms / kg / min ) prevented the decrease in percentage segmental shortening from 32 + / - 12 % to 115 + / - 26 % of the control value ( P < . 01 ) and ST - segment elevation from 5 . 6 + / - 1 . 0 mV to 1 . 6 + / - 1 . 3 mV ( P < . 01 ) at 3 min after ISO infusion with stenosis .
### Output Text: | In contrast to <span class="chemical">nifedipine</span> , <span class="chemical">CD - 832</span> ( 10 micrograms / kg / min ) prevented the decrease in percentage segmental shortening from 32 + / - 12 % to 115 + / - 26 % of the control value ( P < . 01 ) and ST - segment elevation from 5 . 6 + / - 1 . 0 mV to 1 . 6 + / - 1 . 3 mV ( P < . 01 ) at 3 min after <span class="chemical">ISO</span> infusion with stenosis . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Diltiazem ( 30 micrograms / kg / min ) also prevented the decrease in percentage segmental shortening from 34 + / - 14 % to 63 + / - 18 % of the control value ( P < . 05 ) and ST - segment elevation from 4 . 7 + / - 0 . 7 mV to 2 . 1 + / - 0 . 7 mV ( P < . 01 ) at 3 min after ISO infusion with stenosis .
### Output Text: | <span class="chemical">Diltiazem</span> ( 30 micrograms / kg / min ) also prevented the decrease in percentage segmental shortening from 34 + / - 14 % to 63 + / - 18 % of the control value ( P < . 05 ) and ST - segment elevation from 4 . 7 + / - 0 . 7 mV to 2 . 1 + / - 0 . 7 mV ( P < . 01 ) at 3 min after <span class="chemical">ISO</span> infusion with stenosis . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: These data show that CD - 832 improves myocardial ischemia during ISO infusion with stenosis and suggest that the negative chronotropic property of CD - 832 plays a major role in the beneficial effects of CD - 832 .
### Output Text: | These data show that <span class="chemical">CD - 832</span> improves myocardial ischemia during <span class="chemical">ISO</span> infusion with stenosis and suggest that the negative chronotropic property of <span class="chemical">CD - 832</span> plays a major role in the beneficial effects of <span class="chemical">CD - 832</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The effect of recombinant human insulin - like growth factor - I on chronic puromycin aminonucleoside nephropathy in rats .
### Output Text: | The effect of recombinant human insulin - like growth factor - I on chronic <span class="chemical">puromycin aminonucleoside</span> nephropathy in rats . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: We recently demonstrated that recombinant hGH exacerbates renal functional and structural injury in chronic puromycin aminonucleoside ( PAN ) nephropathy , an experimental model of glomerular disease .
### Output Text: | We recently demonstrated that recombinant hGH exacerbates renal functional and structural injury in chronic <span class="chemical">puromycin aminonucleoside</span> ( <span class="chemical">PAN</span> ) nephropathy , an experimental model of glomerular disease . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Therefore , we examined whether recombinant human ( rh ) IGF - I is a safer alternative for the treatment of growth failure in rats with chronic PAN nephropathy .
### Output Text: | Therefore , we examined whether recombinant human ( rh ) IGF - I is a safer alternative for the treatment of growth failure in rats with chronic <span class="chemical">PAN</span> nephropathy . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The glomerulopathy was induced by seven serial injections of PAN over 12 wk .
### Output Text: | The glomerulopathy was induced by seven serial injections of <span class="chemical">PAN</span> over 12 wk . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Experimental animals ( n = 6 ) received rhIGF - I , 400 micrograms / d , whereas control rats ( n = 6 ) received the vehicle .
### Output Text: | Experimental animals ( n = 6 ) received rhIGF - I , 400 micrograms / d , whereas control rats ( n = 6 ) received the vehicle . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: rhIGF - I improved weight gain by 14 % ( p < 0 . 05 ) , without altering hematocrit or blood pressure in rats with renal disease .
### Output Text: | rhIGF - I improved weight gain by 14 % ( p < 0 . 05 ) , without altering hematocrit or blood pressure in rats with renal disease . |
Subsets and Splits