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In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: After i . p . injection to rats , abecarnil and diazepam decreased in a time - dependent and dose - related ( 0 . 25 - 20 mg / kg i . p . ) manner [ 35S ] TBPS binding measured ex vivo in the cerebral cortex .
### Output Text: | After i . p . injection to rats , <span class="chemical">abecarnil</span> and <span class="chemical">diazepam</span> decreased in a time - dependent and dose - related ( 0 . 25 - 20 mg / kg i . p . ) manner <span class="chemical">[ 35S ] TBPS</span> binding measured ex vivo in the cerebral cortex . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Moreover , both drugs at the dose of 0 . 5 mg / kg antagonized completely the convulsant activity and the increase of [ 35S ] TBPS binding induced by isoniazide ( 350 mg / kg s . c . ) as well as the increase of [ 35S ] TBPS binding induced by foot - shock stress .
### Output Text: | Moreover , both drugs at the dose of 0 . 5 mg / kg antagonized completely the convulsant activity and the increase of <span class="chemical">[ 35S ] TBPS</span> binding induced by <span class="chemical">isoniazide</span> ( 350 mg / kg s . c . ) as well as the increase of <span class="chemical">[ 35S ] TBPS</span> binding induced by foot - shock stress . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: To better correlate the biochemical and the pharmacological effects , we studied the action of abecarnil on [ 35S ] TBPS binding , exploratory motility and on isoniazid - induced biochemical and pharmacological effects in mice .
### Output Text: | To better correlate the biochemical and the pharmacological effects , we studied the action of <span class="chemical">abecarnil</span> on <span class="chemical">[ 35S ] TBPS</span> binding , exploratory motility and on <span class="chemical">isoniazid</span> - induced biochemical and pharmacological effects in mice . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: In these animals , abecarnil produced a paralleled dose - dependent ( 0 . 05 - 1 mg / kg i . p . ) reduction of both motor behavior and cortical [ 35S ] TBPS binding .
### Output Text: | In these animals , <span class="chemical">abecarnil</span> produced a paralleled dose - dependent ( 0 . 05 - 1 mg / kg i . p . ) reduction of both motor behavior and cortical [ 35S ] TBPS binding . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Moreover , 0 . 05 mg / kg of this beta - carboline reduced markedly the increase of [ 35S ] TBPS binding and the convulsions induced by isoniazid ( 200 mg / kg s . c . ) . ( ABSTRACT TRUNCATED AT 250 WORDS )
### Output Text: | Moreover , 0 . 05 mg / kg of this <span class="chemical">beta - carboline</span> reduced markedly the increase of <span class="chemical">[ 35S ] TBPS</span> binding and the convulsions induced by <span class="chemical">isoniazid</span> ( 200 mg / kg s . c . ) . ( ABSTRACT TRUNCATED AT 250 WORDS ) |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Recurrent myocardial infarction in a postpartum patient receiving bromocriptine .
### Output Text: | Recurrent myocardial infarction in a postpartum patient receiving <span class="chemical">bromocriptine</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Myocardial infarction in puerperium is infrequently reported .
### Output Text: | Myocardial infarction in puerperium is infrequently reported . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Spasm , coronary dissection , or atheromatous etiology has been described .
### Output Text: | Spasm , coronary dissection , or atheromatous etiology has been described . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Bromocriptine has been implicated in several previous case reports of myocardial infarction in the puerperium .
### Output Text: | <span class="chemical">Bromocriptine</span> has been implicated in several previous case reports of myocardial infarction in the puerperium . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Our case ( including an inadvertent rechallenge ) suggests such a relationship .
### Output Text: | Our case ( including an inadvertent rechallenge ) suggests such a relationship . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Although generally regarded as " safe , " possible serious cardiac effects of bromocriptine should be acknowledged .
### Output Text: | Although generally regarded as " safe , " possible serious cardiac effects of <span class="chemical">bromocriptine</span> should be acknowledged . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Asterixis induced by carbamazepine therapy .
### Output Text: | Asterixis induced by <span class="chemical">carbamazepine</span> therapy . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: There are very few reports about asterixis as a side effect of treatment with psychopharmacologic agents .
### Output Text: | There are very few reports about asterixis as a side effect of treatment with psychopharmacologic agents . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: In this report we present four patients treated with a combination of different psychotropic drugs , in whom asterixis was triggered either by adding carbamazepine ( CBZ ) to a treatment regimen , or by increasing its dosage .
### Output Text: | In this report we present four patients treated with a combination of different psychotropic drugs , in whom asterixis was triggered either by adding <span class="chemical">carbamazepine</span> ( <span class="chemical">CBZ</span> ) to a treatment regimen , or by increasing its dosage . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Neither dosage nor serum levels of CBZ were in a higher range .
### Output Text: | Neither dosage nor serum levels of <span class="chemical">CBZ</span> were in a higher range . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: We consider asterixis to be an easily overlooked sign of neurotoxicity , which may occur even at low or moderate dosage levels , if certain drugs as lithium or clozapine are used in combination with CBZ .
### Output Text: | We consider asterixis to be an easily overlooked sign of neurotoxicity , which may occur even at low or moderate dosage levels , if certain drugs as <span class="chemical">lithium</span> or <span class="chemical">clozapine</span> are used in combination with <span class="chemical">CBZ</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Pharmacodynamics of the hypotensive effect of levodopa in parkinsonian patients .
### Output Text: | Pharmacodynamics of the hypotensive effect of <span class="chemical">levodopa</span> in parkinsonian patients . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Blood pressure effects of i . v . levodopa were examined in parkinsonian patients with stable and fluctuating responses to levodopa .
### Output Text: | Blood pressure effects of i . v . <span class="chemical">levodopa</span> were examined in parkinsonian patients with stable and fluctuating responses to <span class="chemical">levodopa</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The magnitude of the hypotensive effect of levodopa was concentration dependent and was fit to an Emax model in fluctuating responders .
### Output Text: | The magnitude of the hypotensive effect of <span class="chemical">levodopa</span> was concentration dependent and was fit to an Emax model in fluctuating responders . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Stable responders demonstrated a small hypotensive response .
### Output Text: | Stable responders demonstrated a small hypotensive response . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Baseline blood pressures were higher in fluctuating patients ; a higher baseline blood pressure correlated with greater hypotensive effects .
### Output Text: | Baseline blood pressures were higher in fluctuating patients ; a higher baseline blood pressure correlated with greater hypotensive effects . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Antiparkinsonian effects of levodopa temporally correlated with blood pressure changes .
### Output Text: | Antiparkinsonian effects of <span class="chemical">levodopa</span> temporally correlated with blood pressure changes . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Phenylalanine , a large neutral amino acid ( LNAA ) competing with levodopa for transport across the blood - brain barrier , reduced the hypotensive and antiparkinsonian effects of levodopa .
### Output Text: | <span class="chemical">Phenylalanine</span> , a large neutral <span class="chemical">amino acid</span> ( LNAA ) competing with <span class="chemical">levodopa</span> for transport across the blood - brain barrier , reduced the hypotensive and antiparkinsonian effects of <span class="chemical">levodopa</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: We conclude that levodopa has a central hypotensive action that parallels the motor effects in fluctuating patients .
### Output Text: | We conclude that <span class="chemical">levodopa</span> has a central hypotensive action that parallels the motor effects in fluctuating patients . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The hypotensive effect appears to be related to the higher baseline blood pressure we observed in fluctuating patients relative to stable patients .
### Output Text: | The hypotensive effect appears to be related to the higher baseline blood pressure we observed in fluctuating patients relative to stable patients . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Syndrome of inappropriate secretion of antidiuretic hormone after infusional vincristine .
### Output Text: | Syndrome of inappropriate secretion of antidiuretic hormone after infusional <span class="chemical">vincristine</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: A 77 - year - old woman with refractory multiple myeloma was treated with a 4 - day continuous intravenous infusion of vincristine and doxorubicin and 4 days of oral dexamethasone .
### Output Text: | A 77 - year - old woman with refractory multiple myeloma was treated with a 4 - day continuous intravenous infusion of <span class="chemical">vincristine</span> and <span class="chemical">doxorubicin</span> and 4 days of oral <span class="chemical">dexamethasone</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Nine days after her second cycle she presented with lethargy and weakness associated with hyponatremia .
### Output Text: | Nine days after her second cycle she presented with lethargy and weakness associated with hyponatremia . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Evaluation revealed the syndrome of inappropriate secretion of antidiuretic hormone , which was attributed to the vincristine infusion .
### Output Text: | Evaluation revealed the syndrome of inappropriate secretion of antidiuretic hormone , which was attributed to the <span class="chemical">vincristine</span> infusion . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: After normal serum sodium levels returned , further doxorubicin and dexamethasone chemotherapy without vincristine did not produce this complication .
### Output Text: | After normal serum <span class="chemical">sodium</span> levels returned , further <span class="chemical">doxorubicin</span> and <span class="chemical">dexamethasone</span> chemotherapy without <span class="chemical">vincristine</span> did not produce this complication . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Heart failure : to digitalise or not ?
### Output Text: | Heart failure : to digitalise or not ? |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The view against .
### Output Text: | The view against . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Despite extensive clinical experience the role of digoxin is still not well defined .
### Output Text: | Despite extensive clinical experience the role of <span class="chemical">digoxin</span> is still not well defined . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: In patients with atrial fibrillation digoxin is beneficial for ventricular rate control .
### Output Text: | In patients with atrial fibrillation <span class="chemical">digoxin</span> is beneficial for ventricular rate control . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: For patients in sinus rhythm and heart failure the situation is less clear .
### Output Text: | For patients in sinus rhythm and heart failure the situation is less clear . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Digoxin has a narrow therapeutic : toxic ratio and concentrations are affected by a number of drugs .
### Output Text: | <span class="chemical">Digoxin</span> has a narrow therapeutic : toxic ratio and concentrations are affected by a number of drugs . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Also , digoxin has undesirable effects such as increasing peripheral resistance and myocardial demands , and causing arrhythmias .
### Output Text: | Also , <span class="chemical">digoxin</span> has undesirable effects such as increasing peripheral resistance and myocardial demands , and causing arrhythmias . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: There is a paucity of data from well - designed trials .
### Output Text: | There is a paucity of data from well - designed trials . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The trials that are available are generally small with limitations in design and these show variation in patient benefit .
### Output Text: | The trials that are available are generally small with limitations in design and these show variation in patient benefit . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: More convincing evidence is required showing that digoxin improves symptoms or exercise capacity .
### Output Text: | More convincing evidence is required showing that <span class="chemical">digoxin</span> improves symptoms or exercise capacity . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Furthermore , no trial has had sufficient power to evaluate mortality .
### Output Text: | Furthermore , no trial has had sufficient power to evaluate mortality . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Pooled analysis of the effects of other inotropic drugs shows an excess mortality and there is a possibility that digoxin may increase mortality after myocardial infarction ( MI ) .
### Output Text: | Pooled analysis of the effects of other inotropic drugs shows an excess mortality and there is a possibility that <span class="chemical">digoxin</span> may increase mortality after myocardial infarction ( MI ) . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Angiotensin - converting enzyme ( ACE ) inhibitors should be used first as they are safer , do not require blood level monitoring , modify progression of disease , relieve symptoms , improve exercise tolerance and reduce mortality .
### Output Text: | <span class="chemical">Angiotensin</span> - converting enzyme ( ACE ) inhibitors should be used first as they are safer , do not require blood level monitoring , modify progression of disease , relieve symptoms , improve exercise tolerance and reduce mortality . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Caution should be exercised in using digoxin until large mortality trials are completed showing either benefit or harm .
### Output Text: | Caution should be exercised in using <span class="chemical">digoxin</span> until large mortality trials are completed showing either benefit or harm . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Until then digoxin should be considered a third - line therapy .
### Output Text: | Until then <span class="chemical">digoxin</span> should be considered a third - line therapy . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Isradipine treatment for hypertension in general practice in Hong Kong .
### Output Text: | <span class="chemical">Isradipine</span> treatment for hypertension in general practice in Hong Kong . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: A 6 - week open study of the introduction of isradipine treatment was conducted in general practice in Hong Kong .
### Output Text: | A 6 - week open study of the introduction of <span class="chemical">isradipine</span> treatment was conducted in general practice in Hong Kong . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: 303 Chinese patients with mild to moderate hypertension entered the study .
### Output Text: | 303 Chinese patients with mild to moderate hypertension entered the study . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Side effects were reported in 21 % of patients and caused withdrawal from the study in 3 patients .
### Output Text: | Side effects were reported in 21 % of patients and caused withdrawal from the study in 3 patients . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The main side - effects were headache , dizziness , palpitation and flushing and these were not more frequent than reported in other studies with isradipine or with placebo .
### Output Text: | The main side - effects were headache , dizziness , palpitation and flushing and these were not more frequent than reported in other studies with <span class="chemical">isradipine</span> or with placebo . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Supine blood pressure was reduced ( P less than 0 . 01 ) from 170 + / - 20 / 102 + / - 6 mmHg to 153 + / - 19 / 92 + / - 8 , 147 + / - 18 / 88 + / - 7 and 144 + / - 14 / 87 + / - 6 mmHg at 2 , 4 and 6 weeks respectively in evaluable patients .
### Output Text: | Supine blood pressure was reduced ( P less than 0 . 01 ) from 170 + / - 20 / 102 + / - 6 mmHg to 153 + / - 19 / 92 + / - 8 , 147 + / - 18 / 88 + / - 7 and 144 + / - 14 / 87 + / - 6 mmHg at 2 , 4 and 6 weeks respectively in evaluable patients . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Similar reductions occurred in standing blood pressure and there was no evidence of postural hypotension .
### Output Text: | Similar reductions occurred in standing blood pressure and there was no evidence of postural hypotension . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Normalization and responder rates at 6 weeks were 86 % and 69 % respectively .
### Output Text: | Normalization and responder rates at 6 weeks were 86 % and 69 % respectively . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Dosage was increased from 2 . 5 mg b . d . to 5 mg b . d . at 4 weeks in patients with diastolic blood pressure greater than 90 mmHg and their further response was greater than those remaining on 2 . 5 mg b . d .
### Output Text: | Dosage was increased from 2 . 5 mg b . d . to 5 mg b . d . at 4 weeks in patients with diastolic blood pressure greater than 90 mmHg and their further response was greater than those remaining on 2 . 5 mg b . d . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Pharmacological characteristics and side effects of a new galenic formulation of propofol without soyabean oil .
### Output Text: | Pharmacological characteristics and side effects of a new galenic formulation of <span class="chemical">propofol</span> without soyabean oil . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="chemical"> to denote a chemical.
### Input Text: We compared the pharmacokinetics , pharmacodynamics and safety profile of a new galenic formulation of propofol ( AM149 1 % ) , which does not contain soyabean oil , with a standard formulation of propofol ( Disoprivan 1 % ) .
### Output Text: | We compared the pharmacokinetics , pharmacodynamics and safety profile of a new galenic formulation of <span class="chemical">propofol</span> ( AM149 1 % ) , which does not contain soyabean oil , with a standard formulation of <span class="chemical">propofol</span> ( <span class="chemical">Disoprivan</span> 1 % ) . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: In a randomised , double - blind , cross - over study , 30 healthy volunteers received a single intravenous bolus injection of 2 . 5 mg . kg - 1 propofol .
### Output Text: | In a randomised , double - blind , cross - over study , 30 healthy volunteers received a single intravenous bolus injection of 2 . 5 mg . kg - 1 <span class="chemical">propofol</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Plasma propofol levels were measured for 48 h following drug administration and evaluated according to a three - compartment model .
### Output Text: | Plasma <span class="chemical">propofol</span> levels were measured for 48 h following drug administration and evaluated according to a three - compartment model . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The pharmacodynamic parameters assessed included induction and emergence times , respiratory and cardiovascular effects , and pain on injection .
### Output Text: | The pharmacodynamic parameters assessed included induction and emergence times , respiratory and cardiovascular effects , and pain on injection . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Patients were monitored for side effects over 48 h .
### Output Text: | Patients were monitored for side effects over 48 h . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Owing to a high incidence of thrombophlebitis , the study was terminated prematurely and only the data of the two parallel treatment groups ( 15 patients in each group ) were analysed .
### Output Text: | Owing to a high incidence of thrombophlebitis , the study was terminated prematurely and only the data of the two parallel treatment groups ( 15 patients in each group ) were analysed . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="chemical"> to denote a chemical.
### Input Text: Plasma concentrations did not differ significantly between the two formulations .
### Output Text: | Plasma concentrations did not differ significantly between the two formulations . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Anaesthesia induction and emergence times , respiratory and cardiovascular variables showed no significant differences between the two treatment groups .
### Output Text: | Anaesthesia induction and emergence times , respiratory and cardiovascular variables showed no significant differences between the two treatment groups . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Pain on injection ( 80 vs . 20 % , p < 0 . 01 ) and thrombophlebitis ( 93 . 3 vs . 6 . 6 % , p < 0 . 001 ) occurred more frequently with AM149 than with Disoprivan .
### Output Text: | Pain on injection ( 80 vs . 20 % , p < 0 . 01 ) and thrombophlebitis ( 93 . 3 vs . 6 . 6 % , p < 0 . 001 ) occurred more frequently with AM149 than with <span class="chemical">Disoprivan</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Although both formulations had similar pharmacokinetic and pharmacodynamic profiles the new formulation is not suitable for clinical use due to the high incidence of thrombophlebitis produced .
### Output Text: | Although both formulations had similar pharmacokinetic and pharmacodynamic profiles the new formulation is not suitable for clinical use due to the high incidence of thrombophlebitis produced . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Pure red cell aplasia , toxic dermatitis and lymphadenopathy in a patient taking diphenylhydantoin .
### Output Text: | Pure red cell aplasia , toxic dermatitis and lymphadenopathy in a patient taking <span class="chemical">diphenylhydantoin</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: A patient taking diphenylhydantoin for 3 weeks developed a generalized skin rash , lymphadenopathy and pure red cell aplasia .
### Output Text: | A patient taking <span class="chemical">diphenylhydantoin</span> for 3 weeks developed a generalized skin rash , lymphadenopathy and pure red cell aplasia . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: After withdrawal of the pharmacon all symptoms disappeared spontaneously .
### Output Text: | After withdrawal of the pharmacon all symptoms disappeared spontaneously . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Skin rash is a well - known complication of diphenylhydantoin treatment as is benign and malignant lymphadenopathy .
### Output Text: | Skin rash is a well - known complication of <span class="chemical">diphenylhydantoin</span> treatment as is benign and malignant lymphadenopathy . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Pure red cell aplasia associated with diphenylhydantoin medication has been reported in 3 patients .
### Output Text: | Pure red cell aplasia associated with <span class="chemical">diphenylhydantoin</span> medication has been reported in 3 patients . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="chemical"> to denote a chemical.
### Input Text: The exact mechanism by which diphenylhydantoin exerts its toxic effects is not known .
### Output Text: | The exact mechanism by which <span class="chemical">diphenylhydantoin</span> exerts its toxic effects is not known . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: In this patient the time relation between the ingestion of diphenylhydantoin and the occurrence of the skin rash , lymphadenopathy and pure red cell aplasia is very suggestive of a direct connection .
### Output Text: | In this patient the time relation between the ingestion of <span class="chemical">diphenylhydantoin</span> and the occurrence of the skin rash , lymphadenopathy and pure red cell aplasia is very suggestive of a direct connection . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Vinorelbine - related cardiac events : a meta - analysis of randomized clinical trials .
### Output Text: | <span class="chemical">Vinorelbine</span> - related cardiac events : a meta - analysis of randomized clinical trials . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="chemical"> to denote a chemical.
### Input Text: Several cases of cardiac adverse reactions related to vinorelbine ( VNR ) have been reported in the literature .
### Output Text: | Several cases of cardiac adverse reactions related to <span class="chemical">vinorelbine</span> ( <span class="chemical">VNR</span> ) have been reported in the literature . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: In order to quantify the incidence of these cardiac events , we performed a meta - analysis of clinical trials comparing VNR with other chemotherapeutic agents in the treatment of various malignancies .
### Output Text: | In order to quantify the incidence of these cardiac events , we performed a meta - analysis of clinical trials comparing <span class="chemical">VNR</span> with other chemotherapeutic agents in the treatment of various malignancies . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Randomized clinical trials comparing VNR with other drugs in the treatment of cancer were searched in Medline , Embase , Evidence - based Medicine Reviews databases and the Cochrane library from 1987 to 2002 .
### Output Text: | Randomized clinical trials comparing <span class="chemical">VNR</span> with other drugs in the treatment of cancer were searched in Medline , Embase , Evidence - based Medicine Reviews databases and the Cochrane library from 1987 to 2002 . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Outcomes of interest were severe cardiac events , toxic deaths and cardiac event - related deaths reported in each publication .
### Output Text: | Outcomes of interest were severe cardiac events , toxic deaths and cardiac event - related deaths reported in each publication . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: We found 19 trials , involving 2441 patients treated by VNR and 2050 control patients .
### Output Text: | We found 19 trials , involving 2441 patients treated by <span class="chemical">VNR</span> and 2050 control patients . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="chemical"> to denote a chemical.
### Input Text: The incidence of cardiac events with VNR was 1 . 19 % [ 95 % confidence interval ( CI ) ( 0 . 75 ; 1 . 67 ) ] .
### Output Text: | The incidence of cardiac events with <span class="chemical">VNR</span> was 1 . 19 % [ 95 % confidence interval ( CI ) ( 0 . 75 ; 1 . 67 ) ] . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: There was no difference in the risk of cardiac events between VNR and other drugs [ odds ratio : 0 . 92 , 95 % CI ( 0 . 54 ; 1 . 55 ) ] .
### Output Text: | There was no difference in the risk of cardiac events between <span class="chemical">VNR</span> and other drugs [ odds ratio : 0 . 92 , 95 % CI ( 0 . 54 ; 1 . 55 ) ] . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The risk of VNR cardiac events was similar to vindesine ( VDS ) and other cardiotoxic drugs [ fluorouracil , anthracyclines , gemcitabine ( GEM ) em leader ] .
### Output Text: | The risk of <span class="chemical">VNR</span> cardiac events was similar to <span class="chemical">vindesine</span> ( <span class="chemical">VDS</span> ) and other cardiotoxic drugs [ <span class="chemical">fluorouracil</span> , <span class="chemical">anthracyclines</span> , <span class="chemical">gemcitabine</span> ( <span class="chemical">GEM</span> ) em leader ] . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Even if it did not reach statistical significance because of a few number of cases , the risk was lower in trials excluding patients with cardiac history , and seemed to be higher in trials including patients with pre - existing cardiac diseases .
### Output Text: | Even if it did not reach statistical significance because of a few number of cases , the risk was lower in trials excluding patients with cardiac history , and seemed to be higher in trials including patients with pre - existing cardiac diseases . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Vinorelbine - related cardiac events concern about 1 % of treated patients in clinical trials .
### Output Text: | <span class="chemical">Vinorelbine</span> - related cardiac events concern about 1 % of treated patients in clinical trials . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: However , the risk associated with VNR seems to be similar to that of other chemotherapeutic agents in the same indications .
### Output Text: | However , the risk associated with <span class="chemical">VNR</span> seems to be similar to that of other chemotherapeutic agents in the same indications . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: MRI findings of hypoxic cortical laminar necrosis in a child with hemolytic anemia crisis .
### Output Text: | MRI findings of hypoxic cortical laminar necrosis in a child with hemolytic anemia crisis . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="chemical"> to denote a chemical.
### Input Text: We present magnetic resonance imaging findings of a 5 - year - old girl who had a rapidly installing hemolytic anemia crisis induced by trimethoprim - sulfomethoxazole , resulting in cerebral anoxia leading to permanent damage .
### Output Text: | We present magnetic resonance imaging findings of a 5 - year - old girl who had a rapidly installing hemolytic anemia crisis induced by <span class="chemical">trimethoprim - sulfomethoxazole</span> , resulting in cerebral anoxia leading to permanent damage . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="chemical"> to denote a chemical.
### Input Text: Magnetic Resonance imaging revealed cortical laminar necrosis in arterial border zones in both cerebral hemispheres , ischemic changes in subcortical white matter of left cerebral hemisphere , and in the left putamen .
### Output Text: | Magnetic Resonance imaging revealed cortical laminar necrosis in arterial border zones in both cerebral hemispheres , ischemic changes in subcortical white matter of left cerebral hemisphere , and in the left putamen . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="chemical"> to denote a chemical.
### Input Text: Although cortical laminar necrosis is a classic entity in adulthood related to conditions of energy depletions , there are few reports available in children .
### Output Text: | Although cortical laminar necrosis is a classic entity in adulthood related to conditions of energy depletions , there are few reports available in children . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="chemical"> to denote a chemical.
### Input Text: A wide review of the literature is also presented .
### Output Text: | A wide review of the literature is also presented . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The natural history of Vigabatrin associated visual field defects in patients electing to continue their medication .
### Output Text: | The natural history of <span class="chemical">Vigabatrin</span> associated visual field defects in patients electing to continue their medication . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="chemical"> to denote a chemical.
### Input Text: PURPOSE : To determine the natural history of visual field defects in a group of patients known to have Vigabatrin - associated changes who elected to continue the medication because of good seizure control .
### Output Text: | PURPOSE : To determine the natural history of visual field defects in a group of patients known to have <span class="chemical">Vigabatrin</span> - associated changes who elected to continue the medication because of good seizure control . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="chemical"> to denote a chemical.
### Input Text: METHODS : All patients taking Vigabatrin alone or in combination with other antiepileptic drugs for at least 5 years ( range 5 - 12 years ) were entered into a visual surveillance programme .
### Output Text: | METHODS : All patients taking <span class="chemical">Vigabatrin</span> alone or in combination with other antiepileptic drugs for at least 5 years ( range 5 - 12 years ) were entered into a visual surveillance programme . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Patients were followed up at 6 - monthly intervals for not less than 18 months ( range 18 - 43 months ) .
### Output Text: | Patients were followed up at 6 - monthly intervals for not less than 18 months ( range 18 - 43 months ) . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: In all , 16 patients with unequivocal defects continued the medication .
### Output Text: | In all , 16 patients with unequivocal defects continued the medication . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Following already published methodology ( Eye 2002 ; 16 ; 567 - 571 ) monocular mean radial degrees ( MRDs ) to the I / 4e isopter on Goldmann perimetry was calculated for the right eye at the time of discovery of a visual field defect and again after not less than 18 months follow - up .
### Output Text: | Following already published methodology ( Eye 2002 ; 16 ; 567 - 571 ) monocular mean radial degrees ( MRDs ) to the I / 4e isopter on Goldmann perimetry was calculated for the right eye at the time of discovery of a visual field defect and again after not less than 18 months follow - up . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="chemical"> to denote a chemical.
### Input Text: RESULTS : Mean right eye MRD at presentation was 36 . 98 degrees ( range 22 . 25 - 51 . 0 ) , compared to 38 . 40 degrees ( range 22 . 5 - 49 . 75 ) after follow - up ; P = 0 . 338 unpaired t - test .
### Output Text: | RESULTS : Mean right eye MRD at presentation was 36 . 98 degrees ( range 22 . 25 - 51 . 0 ) , compared to 38 . 40 degrees ( range 22 . 5 - 49 . 75 ) after follow - up ; P = 0 . 338 unpaired t - test . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Only one patient demonstrated a deterioration in visual field during the study period and discontinued treatment .
### Output Text: | Only one patient demonstrated a deterioration in visual field during the study period and discontinued treatment . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="chemical"> to denote a chemical.
### Input Text: CONCLUSION : Established visual field defects presumed to be due to Vigabatrin therapy did not usually progress in spite of continuing use of the medication .
### Output Text: | CONCLUSION : Established visual field defects presumed to be due to <span class="chemical">Vigabatrin</span> therapy did not usually progress in spite of continuing use of the medication . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: These data give support to the hypothesis that the pathogenesis of Vigabatrin - associated visual field defects may be an idiosyncratic adverse drug reaction rather than dose - dependent toxicity .
### Output Text: | These data give support to the hypothesis that the pathogenesis of <span class="chemical">Vigabatrin</span> - associated visual field defects may be an idiosyncratic adverse drug reaction rather than dose - dependent toxicity . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Induction of rosaceiform dermatitis during treatment of facial inflammatory dermatoses with tacrolimus ointment .
### Output Text: | Induction of rosaceiform dermatitis during treatment of facial inflammatory dermatoses with <span class="chemical">tacrolimus</span> ointment . |
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