ChEMBL ID
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CHEMBL680132 | F | Inhibition of SP-induced pulmonary edema in guinea-pig 60 min after oral administration at a dose of 1 mg/kg | Cavia porcellus | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 10141 | nan | nan | nan | nan | CHEMBL1136550 | 12565946 | 10.1016/s0960-894x(02)00956-3 | 2003 | Bioorg Med Chem Lett | 13 | 437 | 442 | standard_type:DOSE standard_relation:= standard_value:1.0 standard_units:mg.kg-1 comments:None | standard_type:ROUTE standard_relation:None standard_value:None standard_units:None comments:None | MUSCULO-SKELETAL SYSTEM | Anti-Inflammatory Activity | General Anti-Inflammatory Models | nan | nan |
CHEMBL695872 | F | Minimum inhibitory concentration required for antibacterial activity against Haemophilus influenzae CL 1830 strain;value ranges from 64-128 | Haemophilus influenzae | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 727 | nan | nan | nan | nan | CHEMBL1126507 | nan | 10.1016/S0960-894X(00)80333-9 | 1993 | Bioorg Med Chem Lett | 3 | 1287 | 1292 | nan | nan | nan | nan | nan | nan |
CHEMBL1004912 | B | Activity of Klebsiella pneumoniae KPC-1 beta lactamase expressed in Escherichia coli DH5alpha by SDS-PAGE | Klebsiella pneumoniae | 9 | 18 | BAO_0000019 | assay format | 9 | 9 - Direct single protein target assigned | nan | Scientific Literature | 573 | nan | nan | nan | nan | CHEMBL1137666 | 17875998 | 10.1128/aac.00491-07 | 2007 | Antimicrob Agents Chemother | 51 | 4512 | 4514 | nan | nan | nan | nan | nan | nan |
CHEMBL1219293 | F | Antibacterial activity against efflux-resistant Streptococcus pneumoniae B0326 by agar microdilution method | Streptococcus pneumoniae | 31 | 31 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | B0326 | Scientific Literature | 1313 | nan | nan | nan | nan | CHEMBL1212927 | 20684614 | 10.1021/jm100711p | 2010 | J Med Chem | 53 | 5868 | 5880 | nan | nan | nan | nan | nan | nan |
CHEMBL1012531 | F | Antibacterial activity against Klebsiella pneumoniae UC57 at 30 ug after 24 hrs by disk diffusion method | Klebsiella pneumoniae | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 573 | nan | nan | nan | nan | CHEMBL1152842 | 18417256 | 10.1016/j.ejmech.2008.02.038 | 2009 | Eur J Med Chem | 44 | 365 | 372 | nan | nan | nan | nan | nan | nan |
CHEMBL749314 | F | In vitro growth inhibitory activity on human Lung-NSC (NCI-H460) cell line | Homo sapiens | 2 | 2 | BAO_0000219 | cell-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 9606 | nan | nan | NCI-H460 | nan | CHEMBL1134848 | 12113837 | 10.1016/s0960-894x(02)00305-0 | 2002 | Bioorg Med Chem Lett | 12 | 2039 | 2042 | nan | nan | nan | nan | nan | nan |
CHEMBL1264498 | F | Antimicrobial activity against ciprofloxacin-resistant Streptococcus pneumoniae T24 harboring gyrA mutant gene by agar dilution method | Streptococcus pneumoniae | 2 | 2 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | T24 | Scientific Literature | 1313 | nan | nan | nan | nan | CHEMBL1255248 | 18160515 | 10.1128/aac.00731-07 | 2008 | Antimicrob Agents Chemother | 52 | 822 | 830 | nan | nan | nan | nan | nan | nan |
CHEMBL1262862 | F | Antimicrobial activity against penicillin-intermediate Streptococcus pneumoniae by agar dilution method | Streptococcus pneumoniae | 6 | 18 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 1313 | nan | nan | nan | nan | CHEMBL1255353 | 18362189 | 10.1128/aac.01620-07 | 2008 | Antimicrob Agents Chemother | 52 | 2279 | 2282 | nan | nan | nan | nan | nan | nan |
CHEMBL675916 | B | In vitro inhibition of phosphoramidon-sensitive membrane bound zinc metalloprotease Endothelin-converting enzyme from partially purified guinea pig lungs | Cavia porcellus | 18 | 18 | BAO_0000019 | assay format | 8 | 8 - Homologous single protein target assigned | nan | Scientific Literature | 10141 | nan | nan | nan | nan | CHEMBL1129117 | nan | 10.1016/0960-894X(96)00297-1 | 1996 | Bioorg Med Chem Lett | 6 | 1629 | 1634 | nan | nan | nan | nan | nan | nan |
CHEMBL935596 | F | Antibacterial activity against Streptococcus pneumoniae by broth microdilution method | Streptococcus pneumoniae | 13 | 13 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 1313 | nan | nan | nan | nan | CHEMBL1144730 | 18359228 | 10.1016/j.bmcl.2008.03.032 | 2008 | Bioorg Med Chem Lett | 18 | 2645 | 2648 | nan | nan | nan | nan | nan | nan |
CHEMBL808855 | F | Inhibition of growth of Streptococcus pneumonia | Streptococcus pneumoniae | 7 | 7 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 1313 | nan | nan | nan | nan | CHEMBL1124306 | 3172136 | 10.1021/jm00118a026 | 1988 | J Med Chem | 31 | 2004 | 2008 | nan | nan | nan | nan | nan | nan |
CHEMBL1287049 | F | Antimicrobial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 by microplate alamar blue assay | Mycobacterium tuberculosis | 18 | 36 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | H37Rv ATCC 27294 | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1275300 | 20813433 | 10.1016/j.ejmech.2010.08.029 | 2010 | Eur J Med Chem | 45 | 5164 | 5168 | nan | nan | nan | nan | nan | nan |
CHEMBL847737 | F | Lung/blood distribution ratio was determined in immature female rats at 3h | nan | 2 | 2 | BAO_0000221 | tissue-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | nan | CHEMBL3638235 | Lung | nan | nan | CHEMBL1121966 | 6292424 | 10.1021/jm00353a007 | 1982 | J Med Chem | 25 | 1307 | 1312 | nan | nan | nan | nan | nan | nan |
CHEMBL1266530 | F | Antimicrobial activity against CTX-M-2 and TEM-1 producing Klebsiella pneumoniae transconjugants/transformants with PFGE pulsotype J by Etest in presence of clavulanic acid | Klebsiella pneumoniae | 2 | 2 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 573 | nan | nan | nan | nan | CHEMBL1255347 | 18347108 | 10.1128/aac.01440-07 | 2008 | Antimicrob Agents Chemother | 52 | 1790 | 1793 | nan | nan | nan | nan | nan | nan |
CHEMBL809333 | F | Antibacterial activity determined against gram-positive Streptococcus pneumoniae 6303 | Streptococcus pneumoniae | 14 | 14 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 1313 | nan | nan | nan | nan | CHEMBL1136237 | 12951103 | 10.1016/s0960-894x(03)00661-9 | 2003 | Bioorg Med Chem Lett | 13 | 3253 | 3256 | nan | nan | nan | nan | nan | nan |
CHEMBL631047 | A | Biodistribution values represent the mean % id/organ for paired rats 30 min post intravenous injection complex in Lungs | Rattus norvegicus | 22 | 22 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 10116 | CHEMBL3638235 | Lung | nan | nan | CHEMBL1128489 | 7636856 | 10.1021/jm00015a018 | 1995 | J Med Chem | 38 | 2955 | 2963 | nan | nan | nan | nan | nan | nan |
CHEMBL1019564 | F | Antibacterial activity against Klebsiella pneumoniae after 24 hrs by NCCLS method | Klebsiella pneumoniae | 10 | 10 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 573 | nan | nan | nan | nan | CHEMBL1139333 | 19058973 | 10.1016/j.bmc.2008.11.021 | 2009 | Bioorg Med Chem | 17 | 203 | 221 | nan | nan | nan | nan | nan | nan |
CHEMBL1264804 | F | Antimicrobial activity against Pseudomonas aeruginosa isolate 3149 from fibrosis patient by Etest | Pseudomonas aeruginosa | 10 | 10 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | isolate 3149 | Scientific Literature | 287 | nan | nan | nan | nan | CHEMBL1255447 | 20194693 | 10.1128/aac.00816-09 | 2010 | Antimicrob Agents Chemother | 54 | 2219 | 2224 | nan | nan | nan | nan | nan | nan |
CHEMBL1826963 | F | Antibacterial activity against Klebsiella pneumoniae ATCC 31488 after 24 hrs by broth micro dilution assay | Klebsiella pneumoniae | 35 | 35 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | ATCC 31488 | Scientific Literature | 573 | nan | nan | nan | nan | CHEMBL1821658 | 21752498 | 10.1016/j.ejmech.2011.06.009 | 2011 | Eur J Med Chem | 46 | 4089 | 4099 | nan | nan | nan | nan | nan | nan |
CHEMBL1614236 | F | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | Influenza A virus (A/WSN/1933(H1N1)) | 32268 | 32314 | BAO_0000019 | assay format | 9 | 9 - Direct single protein target assigned | nan | PubChem BioAssays | 382835 | nan | nan | nan | nan | CHEMBL1201862 | nan | nan | nan | nan | nan | nan | nan | nan | nan | nan | nan | nan | nan |
CHEMBL1060489 | F | Antitubercular activity against Mycobacterium tuberculosis H37Rv at 30 ug/disk by microdilution resazurin assay | Mycobacterium tuberculosis | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | H37Rv | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1152948 | 19467603 | 10.1016/j.bmc.2009.04.055 | 2009 | Bioorg Med Chem | 17 | 4693 | 4707 | nan | nan | nan | nan | nan | nan |
CHEMBL687889 | F | In vitro cytotoxicity value corresponding to 50% growth inhibition against HOP-62(non small cell lung) cell line. | Homo sapiens | 16 | 16 | BAO_0000219 | cell-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 9606 | nan | nan | HOP-62 | nan | CHEMBL1130095 | 9240348 | 10.1021/jm9700833 | 1997 | J Med Chem | 40 | 2323 | 2334 | nan | nan | nan | nan | nan | nan |
CHEMBL1266994 | F | Antibacterial activity against Klebsiella pneumoniae clinical isolate by broth microdilution method | Klebsiella pneumoniae | 3 | 9 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 573 | nan | nan | nan | nan | CHEMBL1255373 | 18426902 | 10.1128/aac.01326-07 | 2008 | Antimicrob Agents Chemother | 52 | 2663 | 2666 | nan | nan | nan | nan | nan | nan |
CHEMBL1826116 | B | Inhibition of Mycobacterium tuberculosis DXR assessed as reduction of 1-deoxy-D-xylulose 5-phosphate into 2-C-methyl-D-erythritol-4-phosphate measured for every 5 secs upto 500 secs by spectrophotometry analysis | Mycobacterium tuberculosis | 6 | 6 | BAO_0000357 | single protein format | 9 | 9 - Direct single protein target assigned | nan | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1821696 | 21824775 | 10.1016/j.bmcl.2011.07.005 | 2011 | Bioorg Med Chem Lett | 21 | 5403 | 5407 | nan | nan | nan | nan | nan | nan |
CHEMBL1287474 | F | Antimicrobial activity against aac(6')-Ib-cr-positive Klebsiella pneumoniae JN41T harboring qnrB gene by agar dilution method | Klebsiella pneumoniae | 10 | 10 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | JN41T | Scientific Literature | 573 | nan | nan | nan | nan | CHEMBL1275556 | 18809939 | 10.1128/aac.00830-08 | 2008 | Antimicrob Agents Chemother | 52 | 4268 | 4273 | nan | nan | nan | nan | nan | nan |
CHEMBL628833 | A | Biodistribution in rat lung after 10 min of intravenous injection at a dose of 140-160 g | Rattus norvegicus | 1 | 2 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 10116 | CHEMBL3638235 | Lung | nan | nan | CHEMBL1127602 | 8057294 | 10.1021/jm00041a028 | 1994 | J Med Chem | 37 | 2481 | 2485 | nan | nan | nan | nan | nan | nan |
CHEMBL1259466 | F | Antimicrobial activity against Klebsiella pneumoniae CRE harboring beta-lactamase KPC-2 by broth dilution method | Klebsiella pneumoniae | 4 | 4 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | CRE | Scientific Literature | 573 | nan | nan | nan | nan | CHEMBL1255477 | 20308379 | 10.1128/aac.01525-09 | 2010 | Antimicrob Agents Chemother | 54 | 2291 | 2302 | nan | nan | nan | nan | nan | nan |
CHEMBL690191 | F | Minimal inhibitory concentration against Haemophilus influenza HIN003, beta lactamase producing resistant strain | Haemophilus influenzae | 17 | 17 | BAO_0000019 | assay format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 727 | nan | nan | nan | nan | CHEMBL1132731 | 10999485 | 10.1016/s0960-894x(00)00425-x | 2000 | Bioorg Med Chem Lett | 10 | 2123 | 2127 | nan | nan | nan | nan | nan | nan |
CHEMBL1025290 | F | Antibacterial activity against Streptococcus pneumoniae HMC 1055 harboring S81F mutation in quinolone-resistant determining regions of GyrA gene, S79F, K137N mutation in QRDR of ParC gene and I460V mutation in QRDR of ParE gene by agar dilution method | Streptococcus pneumoniae | 6 | 6 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | HMC 1055 | Scientific Literature | 1313 | nan | nan | nan | nan | CHEMBL1151449 | 17938189 | 10.1128/aac.01229-07 | 2008 | Antimicrob Agents Chemother | 52 | 77 | 84 | nan | nan | nan | nan | nan | nan |
CHEMBL976182 | A | Drug concentration in beta lactamase-negative Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 10 hrs | nan | 2 | 2 | BAO_0000218 | organism-based format | 0 | 0 - Default value - Target unknown or has yet to be assigned | nan | Scientific Literature | nan | nan | nan | nan | nan | CHEMBL1138533 | 17664320 | 10.1128/aac.01530-06 | 2007 | Antimicrob Agents Chemother | 51 | 3699 | 3706 | nan | nan | nan | nan | nan | nan |
CHEMBL973363 | A | Drug concentration in beta lactamase-positive Haemophilus influenzae pharmacokinetic simulation model dosed as amoxicillin-clavulanic acid at simulated human serum concentration of 2000/125 mg, po bid after 10 hrs | nan | 2 | 2 | BAO_0000218 | organism-based format | 0 | 0 - Default value - Target unknown or has yet to be assigned | nan | Scientific Literature | nan | nan | nan | nan | nan | CHEMBL1138533 | 17664320 | 10.1128/aac.01530-06 | 2007 | Antimicrob Agents Chemother | 51 | 3699 | 3706 | nan | nan | nan | nan | nan | nan |
CHEMBL692451 | F | Reversal of keratinization process in hamster tracheal organ culture at concentration of 10e-9 M expressed as percent of active cultures out of 12 cultures | Cricetulus griseus | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 10029 | CHEMBL3638261 | Trachea | nan | nan | CHEMBL1122401 | 6195339 | 10.1021/jm00365a021 | 1983 | J Med Chem | 26 | 1653 | 1656 | nan | nan | nan | nan | nan | nan |
CHEMBL2015865 | F | Antiviral activity against Influenza A virus (A/Weiss/1943(H1N1)) infected in MDCK cells assessed as inhibition of virus-induced cytopathic effects after 3 days by MTT assay | Influenza A virus (A/Weiss/1943(H1N1)) | 29 | 29 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 191090 | nan | nan | MDCK | nan | CHEMBL2010786 | 24900355 | 10.1021/ml2000627 | 2011 | ACS Med Chem Lett | 2 | 603 | 607 | nan | nan | nan | nan | nan | nan |
CHEMBL1228528 | F | Antitubercular activity against Mycobacterium tuberculosis H37Rv after 7 days | Mycobacterium tuberculosis | 43 | 60 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | H37Rv | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1221391 | 20727773 | 10.1016/j.bmc.2010.07.010 | 2010 | Bioorg Med Chem | 18 | 6914 | 6921 | nan | nan | nan | nan | nan | nan |
CHEMBL2060781 | B | Inhibition of Mycobacterium tuberculosis C-terminal His6-tagged MetAP1A using methionylprolyl-p-nitroanilide as substrate incubated for 20 mins prior to substrate addition measured for 20 mins by spectrophotometry in presence of Co2+ | Mycobacterium tuberculosis | 24 | 24 | BAO_0000019 | assay format | 0 | 0 - Default value - Target unknown or has yet to be assigned | nan | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL2057185 | 22704656 | 10.1016/j.bmc.2012.05.022 | 2012 | Bioorg Med Chem | 20 | 4507 | 4513 | nan | nan | nan | nan | nan | nan |
CHEMBL2060841 | F | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv after 2 weeks | Mycobacterium tuberculosis | 14 | 14 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | H37Rv | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL2057185 | 22704656 | 10.1016/j.bmc.2012.05.022 | 2012 | Bioorg Med Chem | 20 | 4507 | 4513 | nan | nan | nan | nan | nan | nan |
CHEMBL2050874 | F | Selectivity index ratio of IC50 for human DU145 cells to MIC for Mycobacterium tuberculosis H37Rv ATCC 27294 | nan | 2 | 2 | BAO_0000219 | cell-based format | 0 | 0 - Default value - Target unknown or has yet to be assigned | nan | Scientific Literature | nan | nan | nan | DU-145 | nan | CHEMBL2046404 | 22449006 | 10.1021/jm300125e | 2012 | J Med Chem | 55 | 3911 | 3922 | nan | nan | nan | nan | nan | nan |
CHEMBL1245414 | F | Antibacterial activity against low dose 5 x 10'6 CFU Streptococcus pneumoniae serotype 2 infected in semitherapeutic C57BL/6 mouse model assessed as bacterial count in lung at 6 mg/kg, ip measured after 5 day post infection | Streptococcus pneumoniae | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | serotype 2 | Scientific Literature | 1313 | nan | nan | nan | nan | CHEMBL1240356 | 19917756 | 10.1128/aac.00943-09 | 2010 | Antimicrob Agents Chemother | 54 | 707 | 717 | standard_type:DOSE standard_relation:= standard_value:6.0 standard_units:mg.kg-1 comments:None | standard_type:ROUTE standard_relation:None standard_value:None standard_units:None comments:None | nan | nan | nan | nan | nan |
CHEMBL1664860 | F | Ratio of IC50 for influenza A (A/Osaka/180/2009 (H1N1)) virus harboring neuraminidase H275Y mutant to IC50 for influenza A (A/Washington/29/2009 (H1N1)) virus expressing wild type enzyme by fetuin substrate based colorimetric assay | Influenza A virus | 5 | 5 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 11320 | nan | nan | nan | nan | CHEMBL1649328 | 20585136 | 10.1128/aac.00581-10 | 2010 | Antimicrob Agents Chemother | 54 | 3671 | 3677 | nan | nan | nan | nan | nan | nan |
CHEMBL1764235 | F | Antitubercular activity against Mycobacterium tuberculosis H37Rv at 1 ug/ml by BACTEC radiometric susceptibility assay | Mycobacterium tuberculosis | 40 | 40 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | H37Rv | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1759873 | 21376591 | 10.1016/j.bmcl.2011.02.008 | 2011 | Bioorg Med Chem Lett | 21 | 2055 | 2058 | nan | nan | nan | nan | nan | nan |
CHEMBL1664840 | F | Ratio of IC50 for influenza A (A/North Carolina/01/2009 (H1N1)) virus harboring neuraminidase H275Y mutant to IC50 for influenza A (A/Washington/29/2009 (H1N1)) virus expressing wild type enzyme by NA-star substrate based chemiluminescent assay | Influenza A virus | 5 | 5 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 11320 | nan | nan | nan | nan | CHEMBL1649328 | 20585136 | 10.1128/aac.00581-10 | 2010 | Antimicrob Agents Chemother | 54 | 3671 | 3677 | nan | nan | nan | nan | nan | nan |
CHEMBL1245866 | A | Drug level in alveolar macrophages of healthy human at 400 mg/kg, po administered as single dose after 10 hrs | Homo sapiens | 1 | 1 | BAO_0000218 | organism-based format | 0 | 0 - Default value - Target unknown or has yet to be assigned | nan | Scientific Literature | 9606 | nan | nan | Macrophage | nan | CHEMBL1240362 | 19933801 | 10.1128/aac.00567-09 | 2010 | Antimicrob Agents Chemother | 54 | 866 | 870 | standard_type:DOSE standard_relation:= standard_value:400.0 standard_units:mg.kg-1 comments:None | standard_type:ROUTE standard_relation:None standard_value:None standard_units:None comments:None | nan | nan | nan | nan | nan |
CHEMBL1245838 | T | Toxicity in healthy human assessed as alveolar macrophage count in bronchoalveolar fluid at 400 mg/kg, po administered as single dose after 10 hrs | Homo sapiens | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 9606 | CHEMBL3638235 | Lung | nan | nan | CHEMBL1240362 | 19933801 | 10.1128/aac.00567-09 | 2010 | Antimicrob Agents Chemother | 54 | 866 | 870 | standard_type:DOSE standard_relation:= standard_value:400.0 standard_units:mg.kg-1 comments:None | standard_type:ROUTE standard_relation:None standard_value:None standard_units:None comments:None | RESPIRATORY SYSTEM | Effects on Air Ways | General Airway Models | nan | nan |
CHEMBL814207 | F | The compound has been evaluated for the antibacterial activity against Streptococcus pneumoniae EryRc 030SJ1 strains | Streptococcus pneumoniae | 9 | 9 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 1313 | nan | nan | nan | nan | CHEMBL1133301 | 10987440 | 10.1016/s0960-894x(00)00392-9 | 2000 | Bioorg Med Chem Lett | 10 | 2019 | 2022 | nan | nan | nan | nan | nan | nan |
CHEMBL1246588 | F | Antibacterial activity against Mycobacterium tuberculosis containing phenotypic rpoB531,rpoB526,rpo533 mutation assessed as microbial sensitivity by phenotypic drug susceptibility testing | Mycobacterium tuberculosis | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1240374 | 20008778 | 10.1128/aac.00964-09 | 2010 | Antimicrob Agents Chemother | 54 | 1075 | 1081 | nan | nan | nan | nan | nan | nan |
CHEMBL1287335 | F | Antimicrobial activity against aac(6')-Ib-cr-positive Klebsiella pneumoniae GZ40 harboring GyrA S83I, ParC S80I mutant, wild-type GyrB and qnrB genes by agar dilution method in presence of clavulanic acid | Klebsiella pneumoniae | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | GZ40 | Scientific Literature | 573 | nan | nan | nan | nan | CHEMBL1275556 | 18809939 | 10.1128/aac.00830-08 | 2008 | Antimicrob Agents Chemother | 52 | 4268 | 4273 | nan | nan | nan | nan | nan | nan |
CHEMBL1112833 | F | Antitumor activity against mouse B16F10 cells xenografted in NCr nu/nu mouse assessed as inhibition of lung metastasis at 35 mg/kg, ip administered after 9 days of tumor implantation for weekly 3 times measured on day 28 post-implantation by hematoxylin-eosin staining | Mus musculus | 2 | 2 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 10090 | nan | nan | B16-F10 | nan | CHEMBL1157126 | 20403700 | 10.1016/j.bmc.2010.03.052 | 2010 | Bioorg Med Chem | 18 | 3575 | 3587 | standard_type:DOSE standard_relation:= standard_value:35.0 standard_units:mg.kg-1 comments:None | standard_type:ROUTE standard_relation:None standard_value:None standard_units:None comments:None | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS | Metastatic Oncology Models | Neoplasm Oncology Models | Xenograft Oncology Models | Metastatic Activity | Neoplasms | Xenograft Models of Anti-Tumor Assays | nan | nan |
CHEMBL2013873 | F | Antiviral activity against MCMV infected in SCID mouse assessed as log10 reduction in viral titer in lung at 10 mg/kg, po relative to control | Murid betaherpesvirus 1 | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 10366 | nan | nan | nan | nan | CHEMBL2010769 | 22417649 | 10.1016/j.bmc.2012.02.031 | 2012 | Bioorg Med Chem | 20 | 2669 | 2674 | standard_type:DOSE standard_relation:= standard_value:10.0 standard_units:mg.kg-1 comments:None | standard_type:ROUTE standard_relation:None standard_value:None standard_units:None comments:None | nan | nan | nan | nan | nan |
CHEMBL621424 | F | In vitro cytotoxicity against human A549 (lung cancer) cell line. | Homo sapiens | 17 | 17 | BAO_0000219 | cell-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 9606 | nan | nan | A549 | nan | CHEMBL1147454 | 15177438 | 10.1016/j.bmcl.2004.04.094 | 2004 | Bioorg Med Chem Lett | 14 | 3385 | 3388 | nan | nan | nan | nan | nan | nan |
CHEMBL635849 | A | Evaluated for biodistribution in rat lung after 6 min of administration | Rattus norvegicus | 4 | 4 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 10116 | CHEMBL3638235 | Lung | nan | nan | CHEMBL1122101 | 7108905 | 10.1021/jm00349a022 | 1982 | J Med Chem | 25 | 870 | 873 | nan | nan | nan | nan | nan | nan |
CHEMBL986544 | F | Cytotoxicity against human Non-small cell lung carcinoma cells | Homo sapiens | 17 | 38 | BAO_0000219 | cell-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 9606 | nan | nan | nan | nan | CHEMBL1155808 | 18598018 | 10.1021/jm800194k | 2008 | J Med Chem | 51 | 4563 | 4570 | nan | nan | nan | nan | nan | nan |
CHEMBL765622 | F | In vitro cytotoxicity was determined by using cultures of human lung (PC9) cancer cells by SRB assay | Homo sapiens | 3 | 3 | BAO_0000219 | cell-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 9606 | nan | nan | PC-9 | nan | CHEMBL1130319 | 9089330 | 10.1021/jm9607966 | 1997 | J Med Chem | 40 | 1090 | 1098 | nan | nan | nan | nan | nan | nan |
CHEMBL810968 | F | In vitro antibacterial activity against Streptococcus pneumoniae 6301 | Streptococcus pneumoniae | 9 | 9 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 1313 | nan | nan | nan | nan | CHEMBL1125894 | 1847430 | 10.1021/jm00106a031 | 1991 | J Med Chem | 34 | 669 | 675 | nan | nan | nan | nan | nan | nan |
CHEMBL1032163 | F | Antimycobacterial activity against mono-rifampin-resistant Mycobacterium tuberculosis TN675 | Mycobacterium tuberculosis | 2 | 2 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1143399 | 10879539 | 10.1038/35016103 | 2000 | Nature | 405 | 962 | 966 | nan | nan | nan | nan | nan | nan |
CHEMBL749419 | F | Minimum inhibitory concentration against Mycobacterium tuberculosis var. bovis strain at 310K, with value expressed as pMIC i.e. -log of MIC (ug/mL). | Mycobacterium tuberculosis | 37 | 37 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1148365 | 15239654 | 10.1021/jm049913k | 2004 | J Med Chem | 47 | 3755 | 3764 | nan | nan | nan | nan | nan | nan |
CHEMBL697077 | F | In vitro antiviral activity against influenza A virus (chile); Compound was inactive at 100 uM and 1000 uM respectively. | Influenza A virus | 7 | 7 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 11320 | nan | nan | nan | nan | CHEMBL1124526 | 2738890 | 10.1021/jm00127a024 | 1989 | J Med Chem | 32 | 1547 | 1551 | nan | nan | nan | nan | nan | nan |
CHEMBL752449 | F | In vitro activity against Mycobacterium strain ING (Mycobacterium tuberculosis) | Mycobacterium tuberculosis | 5 | 5 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1125418 | 1560435 | 10.1021/jm00085a007 | 1992 | J Med Chem | 35 | 1212 | 1215 | nan | nan | nan | nan | nan | nan |
CHEMBL690241 | F | Effective dose administered intratracheally required to give 50% inhibition at 30 minutes prior to installation of human leukocyte elastase in hamster lung | Cricetulus griseus | 7 | 7 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 10029 | CHEMBL3638235 | Lung | nan | nan | CHEMBL1125952 | nan | 10.1016/S0960-894X(01)80463-7 | 1991 | Bioorg Med Chem Lett | 1 | 545 | 550 | nan | nan | nan | nan | nan | nan |
CHEMBL1045353 | F | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv expressing pFCA-luxAB after 10 days by luminescence-based low-oxygen recovery assay | Mycobacterium tuberculosis | 59 | 59 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | H37Rv | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1156790 | 19968290 | 10.1021/jm901378u | 2010 | J Med Chem | 53 | 855 | 866 | nan | nan | nan | nan | nan | nan |
CHEMBL1287465 | F | Antimicrobial activity against aac(6')-Ib-cr-positive Klebsiella pneumoniae JN132 harboring GyrA S83I, ParC S80I mutant, wild-type GyrB and qnrB genes by agar dilution method | Klebsiella pneumoniae | 10 | 10 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | JN132 | Scientific Literature | 573 | nan | nan | nan | nan | CHEMBL1275556 | 18809939 | 10.1128/aac.00830-08 | 2008 | Antimicrob Agents Chemother | 52 | 4268 | 4273 | nan | nan | nan | nan | nan | nan |
CHEMBL663204 | B | Binding affinity against leukotriene receptor (LTD4) from guinea pig lung parenchymal membranes using [3H]LTD4 as radio ligand | Cavia porcellus | 14 | 14 | BAO_0000221 | tissue-based format | 9 | 9 - Direct single protein target assigned | nan | Scientific Literature | 10141 | CHEMBL3987825 | Lung parenchyma | nan | nan | CHEMBL1126589 | 8381184 | 10.1021/jm00055a011 | 1993 | J Med Chem | 36 | 394 | 409 | nan | nan | nan | nan | nan | nan |
CHEMBL1634260 | B | Inhibition of Influenza A virus (A/Aichi/169/2005(H1N1)) neuraminidase after 30 mins by fluorescence analysis | Influenza A virus | 4 | 4 | BAO_0000357 | single protein format | 8 | 8 - Homologous single protein target assigned | (A/Aichi/169/2005(H1N1)) | Scientific Literature | 11320 | nan | nan | nan | nan | CHEMBL1629572 | 18955520 | 10.1128/aac.00333-08 | 2009 | Antimicrob Agents Chemother | 53 | 186 | 192 | nan | nan | nan | nan | nan | nan |
CHEMBL1825403 | F | Antimicrobial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 after 5 days by Microplate Alamar blue assay | Mycobacterium tuberculosis | 67 | 67 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | H37Rv ATCC 27294 | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1821640 | 21776985 | 10.1021/jm2003624 | 2011 | J Med Chem | 54 | 5988 | 5999 | nan | nan | nan | nan | nan | nan |
CHEMBL1662018 | F | Antimicrobial activity against Mycobacterium tuberculosis harboring 261V to G mutation in thymidylate synthase A by agar dilution method | Mycobacterium tuberculosis | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1649181 | 19237648 | 10.1128/aac.01197-08 | 2009 | Antimicrob Agents Chemother | 53 | 2100 | 2109 | nan | nan | nan | nan | nan | nan |
CHEMBL634422 | A | Distribution of radioactivity was determined in lung at 3h after intravenous administration of [125I]-labeled 2-oleoglycerol 1,3-Bis-[omega-(3-amino-2,4,6-triiodophenyl)alkanoates] in rats | Rattus norvegicus | 7 | 7 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 10116 | CHEMBL3638235 | Lung | nan | nan | CHEMBL1128242 | 7861412 | 10.1021/jm00004a010 | 1995 | J Med Chem | 38 | 636 | 646 | nan | nan | nan | nan | nan | nan |
CHEMBL1167419 | B | Inhibition of Influenza A virus A/WSN/1933(H1N1) neuraminidase | Influenza A virus (A/WSN/1933(H1N1)) | 15 | 15 | BAO_0000357 | single protein format | 9 | 9 - Direct single protein target assigned | nan | Scientific Literature | 382835 | nan | nan | nan | nan | CHEMBL1165924 | 20452227 | 10.1016/j.bmc.2010.04.010 | 2010 | Bioorg Med Chem | 18 | 4074 | 4084 | nan | nan | nan | nan | nan | nan |
CHEMBL1815916 | F | Antimicrobial activity against Klebsiella pneumoniae 1190901525 after 24 hrs by broth dilution method | Klebsiella pneumoniae | 11 | 11 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | 1190901525 | Scientific Literature | 573 | nan | nan | nan | nan | CHEMBL1811906 | 21561781 | 10.1016/j.bmc.2011.04.031 | 2011 | Bioorg Med Chem | 19 | 3402 | 3409 | nan | nan | nan | nan | nan | nan |
CHEMBL1065497 | F | Antibacterial activity against Klebsiella pneumoniae NCIB 418 after 24 hrs by agar well diffusion method | Klebsiella pneumoniae | 21 | 21 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | NCIB 418 | Scientific Literature | 573 | nan | nan | nan | nan | CHEMBL1157693 | 19948407 | 10.1016/j.bmc.2009.10.064 | 2010 | Bioorg Med Chem | 18 | 214 | 221 | nan | nan | nan | nan | nan | nan |
CHEMBL872838 | F | Inhibition of non-small cell lung carcinoma (NCI-460) cell proliferation | Homo sapiens | 10 | 10 | BAO_0000219 | cell-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 9606 | nan | nan | NCI-H460 | nan | CHEMBL1136670 | 12657252 | 10.1016/s0960-894x(03)00133-1 | 2003 | Bioorg Med Chem Lett | 13 | 1231 | 1235 | nan | nan | nan | nan | nan | nan |
CHEMBL687271 | F | Compound was evaluated in vivo for inhibition of U 46619 induced increase in tracheal pressure of guinea pig. | Cavia porcellus | 12 | 12 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 10141 | CHEMBL3638261 | Trachea | nan | nan | CHEMBL1151592 | nan | 10.1016/0960-894X(96)00021-2 | 1996 | Bioorg Med Chem Lett | 6 | 349 | 352 | nan | nan | nan | nan | nan | nan |
CHEMBL1738501 | F | PUBCHEM_BIOASSAY: Intein inhibitors as potential Tuberculosis drugs, a cytotoxicity screen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2221, AID2223, AID434968, AID435010, AID449749, AID449750, AID489010] | nan | 77 | 77 | BAO_0000019 | assay format | 0 | 0 - Default value - Target unknown or has yet to be assigned | nan | PubChem BioAssays | nan | nan | nan | nan | nan | CHEMBL1201862 | nan | nan | nan | nan | nan | nan | nan | nan | nan | nan | nan | nan | nan |
CHEMBL1665687 | A | Absorption rate constant in human adults with pulmonary tuberculosis at 600 mg administered twice daily for 7 days | Homo sapiens | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 9606 | nan | nan | nan | nan | CHEMBL1649583 | 19564361 | 10.1128/aac.01378-08 | 2009 | Antimicrob Agents Chemother | 53 | 3981 | 3984 | nan | nan | nan | nan | nan | nan |
CHEMBL932551 | F | Ratio of MIC90 for Mycobacterium tuberculosis H37Rv in iron rich GAST-D medium to MIC90 for Mycobacterium tuberculosis H37Rv in presence of iron limiting GAST-D medium | Mycobacterium tuberculosis | 16 | 16 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | H37Rv | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1144812 | 18394884 | 10.1016/j.bmcl.2008.03.025 | 2008 | Bioorg Med Chem Lett | 18 | 2662 | 2668 | nan | nan | nan | nan | nan | nan |
CHEMBL1049307 | F | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv by agar dilution method | Mycobacterium tuberculosis | 26 | 26 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | H37Rv | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1154729 | 19942326 | 10.1016/j.ejmech.2009.09.033 | 2010 | Eur J Med Chem | 45 | 120 | 123 | nan | nan | nan | nan | nan | nan |
CHEMBL1694771 | F | Antiviral activity against Influenza A virus/NWS/1933(H1N1) infected in BALB/c mouse assessed as survival rate at 50 ug, ip administered once daily for 10 days and dosed 30 mins post infection | Influenza A virus (A/NWS/1933(H1N1)) | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 382819 | nan | nan | nan | nan | CHEMBL1687715 | 18824612 | 10.1128/aac.00506-08 | 2008 | Antimicrob Agents Chemother | 52 | 4331 | 4337 | nan | nan | nan | nan | nan | nan |
CHEMBL1652897 | F | Antimicrobial activity against penicillin-intermediate Streptococcus pneumoniae clinical isolates by broth microdilution method in presence of clavulanate | Streptococcus pneumoniae | 1 | 2 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 1313 | nan | nan | nan | nan | CHEMBL1649268 | 19738026 | 10.1128/aac.00952-09 | 2009 | Antimicrob Agents Chemother | 53 | 4762 | 4771 | nan | nan | nan | nan | nan | nan |
CHEMBL1826567 | B | Reversible inhibition of Mycobacterium tuberculosis DHQ2 | Mycobacterium tuberculosis | 16 | 16 | BAO_0000357 | single protein format | 9 | 9 - Direct single protein target assigned | nan | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1821644 | 21780742 | 10.1021/jm2006063 | 2011 | J Med Chem | 54 | 6063 | 6084 | nan | nan | nan | nan | nan | nan |
CHEMBL1634447 | B | Inhibition of Influenza A virus (A/Yokohama/67/2006(clone 1)(H1N1)) wild type neuraminidase after 30 mins by fluorescence analysis | Influenza A virus | 3 | 3 | BAO_0000357 | single protein format | 8 | 8 - Homologous single protein target assigned | (A/Yokohama/67/2006(clone 1)(H1N1)) | Scientific Literature | 11320 | nan | nan | nan | nan | CHEMBL1629572 | 18955520 | 10.1128/aac.00333-08 | 2009 | Antimicrob Agents Chemother | 53 | 186 | 192 | nan | nan | nan | nan | nan | nan |
CHEMBL812253 | F | In vitro minimum inhibitory concentration against Streptococcus pneumoniae (ATCC 6301) | Streptococcus pneumoniae | 4 | 4 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 1313 | nan | nan | nan | nan | CHEMBL1124193 | 2842501 | 10.1021/jm00117a005 | 1988 | J Med Chem | 31 | 1694 | 1697 | nan | nan | nan | nan | nan | nan |
CHEMBL1174133 | F | Antimycobacterial activity against Mycobacterium tuberculosis CNCTC My 331/88 after 21 days by microdilution method | Mycobacterium tuberculosis | 29 | 29 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | CNCTC My 331/88 | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1177835 | 20226572 | 10.1016/j.ejmech.2010.02.037 | 2010 | Eur J Med Chem | 45 | 2719 | 2725 | nan | nan | nan | nan | nan | nan |
CHEMBL691665 | F | Total cultures(15) versus active (14) at 10e-9 M conc. in hamster tracheal organ culture assay (TOC) | Cricetulus griseus | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 10029 | CHEMBL3638261 | Trachea | nan | nan | CHEMBL1122284 | 6887203 | 10.1021/jm00363a013 | 1983 | J Med Chem | 26 | 1282 | 1293 | nan | nan | nan | nan | nan | nan |
CHEMBL1279368 | F | Antimycobacterial activity against rifampin, ethambutol resistant Mycobacterium tuberculosis isolate 5041 at 37 degC after 3 to 4 weeks by radiometric Bactec 460TB method | Mycobacterium tuberculosis | 3 | 3 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | isolate 5041 | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1275420 | 18378710 | 10.1128/aac.01486-07 | 2008 | Antimicrob Agents Chemother | 52 | 2027 | 2034 | nan | nan | nan | nan | nan | nan |
CHEMBL690251 | F | Inhibition of HNE-induced lung hemorrhage in hamsters after oral administration followed by intratracheal instillation of HNE (10 U/lung) | Cricetulus griseus | 13 | 13 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 10029 | CHEMBL3638235 | Lung | nan | nan | CHEMBL1134847 | 11312926 | 10.1021/jm000410y | 2001 | J Med Chem | 44 | 1268 | 1285 | nan | nan | nan | nan | nan | nan |
CHEMBL1058412 | F | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv after 7 days by microplate alamar blue assay | Mycobacterium tuberculosis | 40 | 40 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | H37Rv | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1154607 | 19817445 | 10.1021/jm901112f | 2009 | J Med Chem | 52 | 6757 | 6767 | nan | nan | nan | nan | nan | nan |
CHEMBL1263973 | F | Antimicrobial activity against Mycobacterium tuberculosis Erdman injected into gamma interferon gene knockout C57BL/6 mouse assessed as bacterial load in spleen of mouse at 100 mg/kg measured 9 days post drug treatment | Mycobacterium tuberculosis | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | Erdman | Scientific Literature | 1773 | CHEMBL3559722 | Spleen | nan | nan | CHEMBL1255311 | 18268091 | 10.1128/aac.00897-07 | 2008 | Antimicrob Agents Chemother | 52 | 1513 | 1515 | standard_type:DOSE standard_relation:= standard_value:100.0 standard_units:mg.kg-1 comments:None | nan | nan | nan | nan | nan |
CHEMBL1284462 | F | Antimicrobial activity against KPC-3 producing Klebsiella pneumoniae 557 ST 327 expressing beta-lactamase TEM-1 by agar dilution method | Klebsiella pneumoniae | 10 | 10 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | 557 | Scientific Literature | 573 | nan | nan | nan | nan | CHEMBL1275589 | 20350950 | 10.1128/aac.01818-09 | 2010 | Antimicrob Agents Chemother | 54 | 3002 | 3006 | nan | nan | nan | nan | nan | nan |
CHEMBL1219382 | F | Antiallergic activity in C57BL/6 mouse assessed as reduction of HDM/CRA-induced chitinase activity in bronchoalveolar lavage fluid at 50 mg/kg, po administered twice daily | Mus musculus | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | C57BL6 | Scientific Literature | 10090 | CHEMBL3638235 | Lung | nan | nan | CHEMBL1212885 | 20666458 | 10.1021/jm100533p | 2010 | J Med Chem | 53 | 6122 | 6128 | standard_type:DOSE standard_relation:= standard_value:50.0 standard_units:mg.kg-1 comments:None | standard_type:ROUTE standard_relation:None standard_value:None standard_units:None comments:None | RESPIRATORY SYSTEM | Effects on Air Ways | General Airway Models | nan | nan |
CHEMBL1279110 | F | Antibacterial activity against Streptococcus pneumoniae SL336-T by broth microdilution method | Streptococcus pneumoniae | 13 | 13 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | SL336-T | Scientific Literature | 1313 | nan | nan | nan | nan | CHEMBL1275417 | 18347114 | 10.1128/aac.01235-07 | 2008 | Antimicrob Agents Chemother | 52 | 1982 | 1990 | nan | nan | nan | nan | nan | nan |
CHEMBL1280031 | F | Antibacterial activity against multidrug resistant Streptococcus pneumoniae MED 1090 assessed as bacterial count at 0.03 ug/ml after 4 hrs by time-kill assay | Streptococcus pneumoniae | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | MED 1090 | Scientific Literature | 1313 | nan | nan | nan | nan | CHEMBL1275440 | 18443122 | 10.1128/aac.01398-07 | 2008 | Antimicrob Agents Chemother | 52 | 2647 | 2652 | nan | nan | nan | nan | nan | nan |
CHEMBL1638768 | F | Antimicrobial activity against Streptococcus constellatus obtained from patient with cystic fibrosis assessed as non-susceptible isolates grown on brain heart infusion agar at 15 ug/ml after 24 hrs at 37 degC by disk diffusion method | Streptococcus constellatus | 2 | 2 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 76860 | nan | nan | nan | nan | CHEMBL1629685 | 20404127 | 10.1128/aac.01845-09 | 2010 | Antimicrob Agents Chemother | 54 | 2823 | 2829 | nan | nan | nan | nan | nan | nan |
CHEMBL1653745 | F | Antimicrobial activity against Klebsiella pneumoniae isolate 202 transconjugant expressing aac(6')-Ib-cr gene | Klebsiella pneumoniae | 8 | 8 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | isolate 202 | Scientific Literature | 573 | nan | nan | nan | nan | CHEMBL1649439 | 19289526 | 10.1128/aac.01534-08 | 2009 | Antimicrob Agents Chemother | 53 | 2643 | 2645 | nan | nan | nan | nan | nan | nan |
CHEMBL801917 | F | Antibacterial activity against Streptococcus pneumoniae 1629 | Streptococcus pneumoniae | 5 | 5 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 1313 | nan | nan | nan | nan | CHEMBL1136775 | 12699381 | 10.1021/jm0204035 | 2003 | J Med Chem | 46 | 1627 | 1635 | nan | nan | nan | nan | nan | nan |
CHEMBL1217738 | F | Antimicrobial activity against Mycobacterium tuberculosis 8C5 harboring embC13 CGG-CTG(Arg-Leu) mutation in embCAB gene after 4 weeks by Bactec 460TB method | Mycobacterium tuberculosis | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | 8C5 | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1212742 | 19822701 | 10.1128/aac.01288-09 | 2010 | Antimicrob Agents Chemother | 54 | 103 | 108 | nan | nan | nan | nan | nan | nan |
CHEMBL1663062 | F | Antimicrobial activity against blaKPC-positive Klebsiella pneumoniae S3 by broth microdilution method | Klebsiella pneumoniae | 10 | 10 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | S3 | Scientific Literature | 573 | nan | nan | nan | nan | CHEMBL1649191 | 19258268 | 10.1128/aac.01355-08 | 2009 | Antimicrob Agents Chemother | 53 | 1998 | 2004 | nan | nan | nan | nan | nan | nan |
CHEMBL1653754 | F | Ratio of MIC for Klebsiella pneumoniae isolate 202 transconjugant to MIC for azide-resistant Escherichia coli J60 | nan | 2 | 2 | BAO_0000019 | assay format | 0 | 0 - Default value - Target unknown or has yet to be assigned | nan | Scientific Literature | nan | nan | nan | nan | nan | CHEMBL1649439 | 19289526 | 10.1128/aac.01534-08 | 2009 | Antimicrob Agents Chemother | 53 | 2643 | 2645 | nan | nan | nan | nan | nan | nan |
CHEMBL1105348 | F | Antiviral activity against Influenza B virus Malaysia/2506/2004 infected MDCK cells assessed as inhibition of virus-induced cytopathic effect after 3 days | Influenza B virus | 3 | 4 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | B/Malaysia/2506/2004 | Scientific Literature | 11520 | nan | nan | MDCK | nan | CHEMBL1156973 | 20231094 | 10.1016/j.bmcl.2010.02.074 | 2010 | Bioorg Med Chem Lett | 20 | 2601 | 2604 | nan | nan | nan | nan | nan | nan |
CHEMBL1653740 | F | Antimicrobial activity against Klebsiella pneumoniae isolate 132 expressing aac(6')-Ib-cr gene | Klebsiella pneumoniae | 8 | 8 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | isolate 132 | Scientific Literature | 573 | nan | nan | nan | nan | CHEMBL1649439 | 19289526 | 10.1128/aac.01534-08 | 2009 | Antimicrob Agents Chemother | 53 | 2643 | 2645 | nan | nan | nan | nan | nan | nan |
CHEMBL2016048 | F | Antiviral activity against Vaccinia virus infected in human lung fibroblast assessed as inhibition of virus-induced cytopathic effect at 0.32 to 100 uM | Vaccinia virus | 35 | 35 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 10245 | nan | nan | nan | nan | CHEMBL2010803 | 22405290 | 10.1016/j.ejmech.2012.02.046 | 2012 | Eur J Med Chem | 51 | 227 | 238 | nan | nan | nan | nan | nan | nan |
CHEMBL1116958 | A | Selectivity ratio of IC50 for MDCK cells to EC50 for inhibition of virus-induced cytopathic effect of Influenza A virus Wisconsin/67/2005/H3N2 | nan | 3 | 4 | BAO_0000219 | cell-based format | 0 | 0 - Default value - Target unknown or has yet to be assigned | nan | Scientific Literature | nan | nan | nan | MDCK | nan | CHEMBL1156973 | 20231094 | 10.1016/j.bmcl.2010.02.074 | 2010 | Bioorg Med Chem Lett | 20 | 2601 | 2604 | nan | nan | nan | nan | nan | nan |
CHEMBL967121 | A | Biodistribution in lung of C57BL/6 mouse bearing mouse B16-F0 cells at 0.74 to 0.92 MBq, iv after 1 hr | Mus musculus | 4 | 4 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | C57BL/6 | Scientific Literature | 10090 | CHEMBL3638235 | Lung | B16-F0 | nan | CHEMBL1155960 | 18656367 | 10.1016/j.bmc.2008.07.015 | 2008 | Bioorg Med Chem | 16 | 7671 | 7690 | nan | nan | nan | nan | nan | nan |
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