ChEMBL ID
stringlengths 12
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| Assay Type
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stringlengths 18
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| Organism
stringclasses 304
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stringclasses 166
values | Activities
stringclasses 176
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stringclasses 10
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stringlengths 1
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stringclasses 17
values | Tax ID
stringclasses 283
values | Tissue ChEMBL ID
stringclasses 67
values | Tissue Name
stringclasses 70
values | Cell Type
stringclasses 314
values | Subcellular Fraction
stringclasses 14
values | Document ChEMBL ID
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| PubMed ID
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8
| DOI
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31
| Year
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stringclasses 244
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stringlengths 1
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stringlengths 1
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| Assay Parameters
stringclasses 285
values | Assay Classification L1
stringclasses 37
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stringclasses 134
values | Variant Sequence Accession
stringclasses 21
values | Variant Sequence Mutation
stringclasses 50
values |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CHEMBL5143199 | B | Inhibition of recombinant SARS-COV2 main protease expressed in Escherichia coli Rosetta cells at 5 uM using DABCYL-KTSAVLQSGFRKME-EDANS as substrate pre-incubated for 60 mins followed by substarte addition measured at 5 min by FRET-based assay relative to control | Severe acute respiratory syndrome coronavirus 2 | 1 | 1 | BAO_0000219 | cell-based format | 9 | 9 - Direct single protein target assigned | nan | Scientific Literature | 2697049 | nan | nan | nan | nan | CHEMBL5137122 | 36098617 | 10.1021/acs.jnatprod.2c00521 | 2022 | J Nat Prod | 85 | 2340 | 2350 | nan | nan | nan | nan | nan | nan |
CHEMBL5233152 | F | Synergistic antibacterial activity against Klebsiella pneumoniae B9 assessed as reduction in colony forming unit at 5 uM measured at 6 to 24 hrs in the presence of 4 ug/ml of colistin by time-kill assay | Klebsiella pneumoniae | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | B9 | Scientific Literature | 573 | nan | nan | nan | nan | CHEMBL5230178 | 36846374 | 10.1039/d2md00370h | 2023 | RSC Med Chem | 14 | 247 | 252 | nan | nan | nan | nan | nan | nan |
CHEMBL4199288 | B | Inhibition of human lung tryptase using Z-glypro-arg-AMC incubated for 3 mins by spectrophotometry | Homo sapiens | 1 | 1 | BAO_0000224 | protein format | 5 | 5 - Multiple direct protein targets may be assigned | nan | Scientific Literature | 9606 | nan | nan | nan | nan | CHEMBL4196099 | 29775297 | 10.1021/acs.jmedchem.8b00173 | 2018 | J Med Chem | 61 | 7425 | 7447 | nan | nan | nan | nan | nan | nan |
CHEMBL5233492 | F | Antibacterial activity against Mycobacterium tuberculosis | Mycobacterium tuberculosis | 2 | 2 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL5233210 | 31761383 | 10.1016/j.ejmech.2019.111893 | 2020 | Eur J Med Chem | 186 | 111893 | 111893 | nan | nan | nan | nan | nan | nan |
CHEMBL5159782 | F | Antiviral activity against influenza A virus H5N1 infected in dog MDCK cells assessed as inhibition of virus particles replication at 1 uM incubated for 48 hrs by crystal violet staining based plaque formation assay | Influenza A virus | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | H5N1 | Scientific Literature | 11320 | nan | nan | MDCK | nan | CHEMBL5154759 | 35212527 | 10.1021/acs.jmedchem.1c01257 | 2022 | J Med Chem | 65 | 3814 | 3832 | nan | nan | nan | nan | nan | nan |
CHEMBL5098361 | F | Synergistic antibacterial activity against carbapenem-resistant Klebsiella pneumoniae expressing NDM-1 measured after 18 hrs in the presence of meropenem | Klebsiella pneumoniae | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 573 | nan | nan | nan | nan | CHEMBL5096195 | 34225181 | 10.1016/j.ejmech.2021.113667 | 2021 | Eur J Med Chem | 223 | 113667 | 113667 | nan | nan | nan | nan | nan | nan |
CHEMBL5036109 | F | Protection against Influenza A virus (A/Puerto Rico/8/34 (H1N1)) infected in Balb/c mouse at 4.2 uM/kg, IN administered once daily for 7 days starting from 24 hrs post viral infection | Influenza A virus | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | A/Puerto Rico/8/1934(H1N1) | Scientific Literature | 11320 | nan | nan | nan | nan | CHEMBL5034038 | 34797984 | 10.1021/acs.jmedchem.1c01531 | 2021 | J Med Chem | 64 | 17403 | 17412 | nan | nan | nan | nan | nan | nan |
CHEMBL5034152 | F | Anti-tumor activity against mouse lewis lung carcinoma cells allografted in C57BL6 mouse assessed as reduction in tumor growth at 2 mg/kg, ig for 21 days relative to control | Mus musculus | 1 | 1 | BAO_0000218 | organism-based format | 0 | 0 - Default value - Target unknown or has yet to be assigned | nan | Scientific Literature | 10090 | nan | nan | Lewis lung carcinoma cell line | nan | CHEMBL5033993 | 34037385 | 10.1021/acs.jmedchem.1c00370 | 2021 | J Med Chem | 64 | 7646 | 7666 | nan | nan | nan | nan | nan | nan |
CHEMBL4010211 | F | Antibacterial activity against Pseudomonas aeruginosa PA1145 in BALB/c mouse model of lung infection assessed as reduction in log10CFU per gram of lung at 15 mg/kg, iv bid administered 2 to 12 hrs of post-infection measured after 24 hrs relative to untreated control | Pseudomonas aeruginosa | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | PA1145 | Scientific Literature | 287 | nan | nan | nan | nan | CHEMBL4007456 | 28248499 | 10.1021/acs.jmedchem.6b01903 | 2017 | J Med Chem | 60 | 2498 | 2512 | nan | nan | nan | nan | nan | nan |
CHEMBL5105375 | T | Toxicity in BALB/c nude mouse xenografted with human NCI-H460 cells assessed as morphological change in lung at 0.2 mg/kg administered ip, qd for 2 weeks | Mus musculus | 1 | 1 | BAO_0000218 | organism-based format | 0 | 0 - Default value - Target unknown or has yet to be assigned | BALB/c nude | Scientific Literature | 10090 | CHEMBL3638235 | Lung | NCI-H460 | nan | CHEMBL5104115 | 35617856 | 10.1016/j.ejmech.2022.114463 | 2022 | Eur J Med Chem | 238 | 114463 | 114463 | nan | nan | nan | nan | nan | nan |
CHEMBL5235082 | F | Antitubercular activity against Mycobacterium tuberculosis H37 Rv ATCC 27294 incubated for 7 days by Alamar blue assay | Mycobacterium tuberculosis | 2 | 2 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | H37 Rv ATCC 27294 | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL5233258 | 32731188 | 10.1016/j.ejmech.2020.112609 | 2020 | Eur J Med Chem | 204 | 112609 | 112609 | nan | nan | nan | nan | nan | nan |
CHEMBL5235188 | F | Antibacterial activity against Mycobacterium tuberculosis H37Rv MTCC 200 strain assessed as bacterial growth inhibition | Mycobacterium tuberculosis | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | H37Rv MTCC 200 | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL5233261 | 33388593 | 10.1016/j.ejmech.2020.113069 | 2021 | Eur J Med Chem | 212 | 113069 | 113069 | nan | nan | nan | nan | nan | nan |
CHEMBL5261296 | F | Antiviral activity against oseltamivir resistant Influenza A virus A/Georgia/20/2006 (H1N1) infected in MDCK cells incubated for 72 hrs by cell protection assay | Influenza A virus | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | A/Georgia/20/2006 (H1N1) | Scientific Literature | 11320 | nan | nan | MDCK | nan | CHEMBL5260803 | 28197322 | 10.1021/acsmedchemlett.6b00486 | 2017 | ACS Med Chem Lett | 8 | 256 | 260 | nan | nan | nan | nan | nan | nan |
CHEMBL4815677 | F | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv incubated for 5 days by microplate alamar blue assay | Mycobacterium tuberculosis | 16 | 16 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | H37Rv | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL4813957 | 33588179 | 10.1016/j.ejmech.2021.113266 | 2021 | Eur J Med Chem | 215 | 113266 | 113266 | nan | nan | nan | nan | nan | nan |
CHEMBL5108869 | A | Ex vivo biodistribution in SJL mouse lung at 3.7 MBq,iv measured after 30 mins in presence of C-11 radiotracer by gamma counter method | Mus musculus | 1 | 1 | BAO_0000218 | organism-based format | 0 | 0 - Default value - Target unknown or has yet to be assigned | SJL | Scientific Literature | 10090 | CHEMBL3638235 | Lung | nan | nan | CHEMBL5107960 | 35308025 | 10.1039/d1md00357g | 2022 | RSC Med Chem | 13 | 202 | 207 | nan | nan | nan | nan | nan | nan |
CHEMBL4881605 | F | Lung NCI-1-1460 cell line MDS Pharma Services Proliferation Assay | Homo sapiens | 1 | 8 | BAO_0000219 | cell-based format | 0 | 0 - Default value - Target unknown or has yet to be assigned | nan | Donated Chemical Probes - SGC Frankfurt | 9606 | nan | nan | Lung NCI-1-1460 | nan | CHEMBL4507274 | nan | 10.6019/CHEMBL4507274 | 2021 | nan | nan | nan | nan | nan | nan | nan | nan | nan | nan |
CHEMBL5143159 | F | Antiviral activity against Influenza A virus A/WSN/33(H1N1) infected in HEK293T cells assessed as inhibition of viral replication at 50 uM by Gaussia luciferase assay | Influenza A virus | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | A/WSN/33(H1N1) | Scientific Literature | 11320 | nan | nan | HEK293T | nan | CHEMBL5137116 | 36040315 | 10.1021/acs.jnatprod.2c00335 | 2022 | J Nat Prod | 85 | 2142 | 2148 | nan | nan | nan | nan | nan | nan |
CHEMBL5215160 | F | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv assessed as reduction in bacterial growth and measured after 7 days by resazurin assay | Mycobacterium tuberculosis | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | H37Rv | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL5214886 | 33190957 | 10.1016/j.ejmech.2020.112967 | 2021 | Eur J Med Chem | 210 | 112967 | 112967 | nan | nan | nan | nan | nan | nan |
CHEMBL5247890 | F | Synergistic antibacterial activity against Klebsiella pneumoniae 11978 producing OXA-48 assessed as cefepime MIC at 8 ug/ml by broth microdilution method | Klebsiella pneumoniae | 3 | 3 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 573 | nan | nan | nan | nan | CHEMBL5247575 | 29627985 | 10.1021/acs.jmedchem.8b00091 | 2018 | J Med Chem | 61 | 4067 | 4086 | nan | nan | nan | nan | nan | nan |
CHEMBL5260257 | B | Inhibition of full length SARS-CoV-2 3CL protease expressed in Escherichia coli BL21 (DE3) using Dacyl-KTSAVLQSGFRKME-Edans fluorogenic peptide as substrate pre-incubated for 10 mins followed by substrate addition by FRET assay | Severe acute respiratory syndrome coronavirus 2 | 6 | 6 | BAO_0000019 | assay format | 9 | 9 - Direct single protein target assigned | nan | Scientific Literature | 2697049 | nan | nan | nan | nan | CHEMBL5257128 | 37187077 | 10.1016/j.bmc.2023.117316 | 2023 | Bioorg Med Chem | 87 | 117316 | 117316 | nan | nan | nan | nan | nan | nan |
CHEMBL5216483 | F | Antiviral activity against SARS-CoV-2 isolate 2019-nCoV/Italy-INMI1 infected in African green monkey Vero E6 cells assessed as reduction in viral replication at MOI of 0.01 incubated for 5 days by qRT-PCR analysis | Severe acute respiratory syndrome coronavirus 2 | 2 | 2 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | 2019-nCoV/Italy-INMI1 | Scientific Literature | 2697049 | nan | nan | Vero E6 | nan | CHEMBL5214928 | 35899912 | 10.1021/acs.jmedchem.2c00755 | 2022 | J Med Chem | 65 | 10195 | 10216 | nan | nan | nan | nan | nan | nan |
CHEMBL5040410 | A | Drug accumulation in mouse 4T1 cells implanted female BALB/c mouse lung at 0.5 mg/kg, iv by fluorescence detector | Mus musculus | 1 | 1 | BAO_0000218 | organism-based format | 0 | 0 - Default value - Target unknown or has yet to be assigned | BALB/c | Scientific Literature | 10090 | CHEMBL3638235 | Lung | 4T1 | nan | CHEMBL5038609 | 34547508 | 10.1016/j.ejmech.2021.113851 | 2021 | Eur J Med Chem | 226 | 113851 | 113851 | nan | nan | nan | nan | nan | nan |
CHEMBL4365274 | F | Antitubercular activity against Mycobacterium tuberculosis H37Rv ATCC 27294 assessed as bacterial growth inhibition incubated for 5 days by standard microdilution method | Mycobacterium tuberculosis | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | H37Rv ATCC 27294 | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL4364263 | 31195172 | 10.1016/j.ejmech.2019.05.082 | 2019 | Eur J Med Chem | 178 | 315 | 328 | nan | nan | nan | nan | nan | nan |
CHEMBL5120223 | A | Drug elimination in ICR mouse lung at 100 mg/kg, ip measured for 1.5 hrs by UPLC-MS/MS analysis | Mus musculus | 1 | 1 | BAO_0000218 | organism-based format | 0 | 0 - Default value - Target unknown or has yet to be assigned | ICR | Scientific Literature | 10090 | CHEMBL3638235 | Lung | nan | nan | CHEMBL5113532 | 36089748 | 10.1021/acs.jmedchem.2c00532 | 2022 | J Med Chem | 65 | 11970 | 11984 | nan | nan | nan | nan | nan | nan |
CHEMBL5259546 | F | Antiviral activity against Influenza B virus infected in dog MDCK cells assessed as inhibition of viral replication measured after 15 to 30 mins by neutral red dye based analysis | Influenza B virus | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 11520 | nan | nan | MDCK | nan | CHEMBL5257097 | 37077387 | 10.1021/acsmedchemlett.3c00048 | 2023 | ACS Med Chem Lett | 14 | 506 | 513 | nan | nan | nan | nan | nan | nan |
CHEMBL5259549 | T | Cytotoxicity against dog MDCK cells infected with Influenza A virus H3N2 assessed as reduction in cell viability by visual analysis | Canis lupus familiaris | 1 | 1 | BAO_0000219 | cell-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 9615 | nan | nan | MDCK | nan | CHEMBL5257097 | 37077387 | 10.1021/acsmedchemlett.3c00048 | 2023 | ACS Med Chem Lett | 14 | 506 | 513 | nan | nan | nan | nan | nan | nan |
CHEMBL5265568 | F | Antitubercular activity against Mycobacterium tuberculosis H37Rv assessed as bacterial growth inhibition | Mycobacterium tuberculosis | 12 | 12 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | H37Rv | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL5260858 | 36804747 | 10.1016/j.bmc.2023.117212 | 2023 | Bioorg Med Chem | 81 | 117212 | 117212 | nan | nan | nan | nan | nan | nan |
CHEMBL4022752 | T | Toxicity in diabetic ZDF rat assessed as increase in cyclin D1 mRNA levels in lung administered at 130 mg/kg/day infused over 20 hrs | Rattus norvegicus | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | ZDF | Scientific Literature | 10116 | CHEMBL3638235 | Lung | nan | nan | CHEMBL4020814 | 29016121 | 10.1021/acs.jmedchem.7b00922 | 2017 | J Med Chem | 60 | 8482 | 8514 | nan | ALIMENTARY TRACT AND METABOLISM | ALIMENTARY TRACT AND METABOLISM | Genetically Diabetic Animals | Measurement of Blood Glucose-Lowering and Antidiabetic Activity | Spontaneously Diabetic Rats: BB Rat, WBN/Kob Rat, Cohen Diabetic Rat, Goto-Kakizaki Rat, Zucker-Fatty Rat, Zucker Diabetic Fatty Rat Zdf/Drt-Fa, Wdf/Ta-Fa Rat, OLETF Rat, ESS-Rat, Obese SHR Rat, SHR/N-cp Rat, BHE Rat, LEW.1AR1/Ztm-iddm RAT | General Anti-Diabetic Activity | nan | nan |
CHEMBL5225100 | F | Antiviral activity against SARS-CoV-2 infected in human Calu-3 cells assessed as reduction in viral RNA level measured after 24 hrs by quantitative PCR analysis | Severe acute respiratory syndrome coronavirus 2 | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 2697049 | nan | nan | Calu-3 | nan | CHEMBL5223130 | 36169610 | 10.1021/acs.jmedchem.2c01005 | 2022 | J Med Chem | 65 | 12500 | 12534 | nan | nan | nan | nan | nan | nan |
CHEMBL5158458 | T | Toxicity in ICR mouse allografted with mouse H22 cells assessed as effect on lung morphology at 10 to 20 mg/kg, iv administered once a day for 21 days after 7 days of tumor implantation by H and E staining method | Mus musculus | 1 | 1 | BAO_0000218 | organism-based format | 0 | 0 - Default value - Target unknown or has yet to be assigned | ICR | Scientific Literature | 10090 | CHEMBL3638235 | Lung | nan | nan | CHEMBL5154722 | 35121201 | 10.1016/j.ejmech.2022.114155 | 2022 | Eur J Med Chem | 231 | 114155 | 114155 | nan | nan | nan | nan | nan | nan |
CHEMBL5096248 | F | Antiviral activity against SARS-CoV-2 | Severe acute respiratory syndrome coronavirus 2 | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 2697049 | nan | nan | nan | nan | CHEMBL5096141 | 33191083 | 10.1016/j.bmc.2020.115860 | 2021 | Bioorg Med Chem | 29 | 115860 | 115860 | nan | nan | nan | nan | nan | nan |
CHEMBL5216115 | F | Antitubercular activity against Mycobacterium tuberculosis H37Rv ATCC 25618 assessed as bacterial growth inhibition | Mycobacterium tuberculosis | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | H37Rv ATCC 25618 | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL5214920 | 35597009 | 10.1016/j.ejmech.2022.114454 | 2022 | Eur J Med Chem | 238 | 114454 | 114454 | nan | nan | nan | nan | nan | nan |
CHEMBL5225104 | F | Antiviral activity against SARS-CoV-2 2019-nCoV/USA_WA1/2020 infected in African green monkey Vero E6 cells assessed as reduction in virus induced cytopathic effect measured after 72 hrs | Severe acute respiratory syndrome coronavirus 2 | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | 2019-nCoV/USA_WA1/2020 | Scientific Literature | 2697049 | nan | nan | Vero E6 | nan | CHEMBL5223130 | 36169610 | 10.1021/acs.jmedchem.2c01005 | 2022 | J Med Chem | 65 | 12500 | 12534 | nan | nan | nan | nan | nan | nan |
CHEMBL5225116 | B | Inhibition of SARS-CoV-2 Main protease by FRET assay | Severe acute respiratory syndrome coronavirus 2 | 7 | 7 | BAO_0000357 | single protein format | 9 | 9 - Direct single protein target assigned | nan | Scientific Literature | 2697049 | nan | nan | nan | nan | CHEMBL5223130 | 36169610 | 10.1021/acs.jmedchem.2c01005 | 2022 | J Med Chem | 65 | 12500 | 12534 | nan | nan | nan | nan | nan | nan |
CHEMBL5229468 | T | Selectivity index, ratio of IC50 for cytotoxicity against mouse pulmonary fibroblast cells to IC50 for cytotoxicity against mouse B16-F10 cells | nan | 2 | 2 | BAO_0000219 | cell-based format | 0 | 0 - Default value - Target unknown or has yet to be assigned | nan | Scientific Literature | nan | nan | nan | nan | nan | CHEMBL5226367 | 36542806 | 10.1021/acs.jnatprod.2c00880 | 2023 | J Nat Prod | 86 | 166 | 175 | nan | nan | nan | nan | nan | nan |
CHEMBL5258998 | F | Antibacterial activity against Streptococcus pneumoniae | Streptococcus pneumoniae | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 1313 | nan | nan | nan | nan | CHEMBL5257082 | 37030567 | 10.1016/j.bmcl.2023.129276 | 2023 | Bioorg Med Chem Lett | 87 | 129276 | 129276 | nan | nan | nan | nan | nan | nan |
CHEMBL5215165 | F | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv assessed as reduction in bacterial growth by MABA analysis | Mycobacterium tuberculosis | 7 | 7 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | H37Rv | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL5214886 | 33190957 | 10.1016/j.ejmech.2020.112967 | 2021 | Eur J Med Chem | 210 | 112967 | 112967 | nan | nan | nan | nan | nan | nan |
CHEMBL5159780 | F | Antiviral activity against influenza A virus H5N1 infected in dog MDCK cells assessed as reduction in viral nucleoprotein expression at 0.8 uM measured at 12 hrs post infection by Western blot analysis | Influenza A virus | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | H5N1 | Scientific Literature | 11320 | nan | nan | MDCK | nan | CHEMBL5154759 | 35212527 | 10.1021/acs.jmedchem.1c01257 | 2022 | J Med Chem | 65 | 3814 | 3832 | nan | nan | nan | nan | nan | nan |
CHEMBL5227019 | F | Antiviral activity against SARS-CoV-2 infected in Vero E6 cells assessed as reduction in viral replication measured after 24 hrs by plaque-reduction assay | Severe acute respiratory syndrome coronavirus 2 | 2 | 2 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 2697049 | nan | nan | nan | nan | CHEMBL5226291 | 33486200 | 10.1016/j.ejmech.2021.113157 | 2021 | Eur J Med Chem | 213 | 113157 | 113157 | nan | nan | nan | nan | nan | nan |
CHEMBL5231922 | F | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv at 32 microg/ml measured for 48 hrs under hypoxia condition by resazurin dye based microplate reader analysis relative to control | Mycobacterium tuberculosis | 4 | 4 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | H37Rv | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL5230134 | 33151678 | 10.1021/acs.jmedchem.0c01372 | 2020 | J Med Chem | 63 | 15726 | 15751 | nan | nan | nan | nan | nan | nan |
CHEMBL5243945 | T | Toxicity in ICR mouse xenografted with human H22 cells assessed as abnormalities in lung at 20 mg/kg, iv administered for 21 days | Mus musculus | 1 | 1 | BAO_0000218 | organism-based format | 0 | 0 - Default value - Target unknown or has yet to be assigned | ICR | Scientific Literature | 10090 | CHEMBL3638235 | Lung | nan | nan | CHEMBL5241127 | 36640595 | 10.1016/j.bmc.2023.117156 | 2023 | Bioorg Med Chem | 79 | 117156 | 117156 | nan | nan | nan | nan | nan | nan |
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