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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CHEMBL1675146 | F | Antibacterial activity against ceftazidime-susceptible Klebsiella pneumoniae by CLSI M7-A7 broth microdilution method | Klebsiella pneumoniae | 9 | 27 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 573 | nan | nan | nan | nan | CHEMBL1671626 | 18625769 | 10.1128/aac.00149-08 | 2008 | Antimicrob Agents Chemother | 52 | 3398 | 3407 | nan | nan | nan | nan | nan | nan |
CHEMBL1675149 | F | Antibacterial activity against ceftazidime-nonsusceptible Klebsiella pneumoniae by CLSI M7-A7 broth microdilution method | Klebsiella pneumoniae | 9 | 27 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 573 | nan | nan | nan | nan | CHEMBL1671626 | 18625769 | 10.1128/aac.00149-08 | 2008 | Antimicrob Agents Chemother | 52 | 3398 | 3407 | nan | nan | nan | nan | nan | nan |
CHEMBL1954152 | F | Antitubercular activity against multidrug-resistant isoniazid, rifampicin, ethambutol, pyrazinamide, rifabutin, thioacetazone/ethionamide-resistant Mycobacterium tuberculosis clinical isolate by microbroth dilution assay | Mycobacterium tuberculosis | 3 | 3 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1949614 | 21691438 | 10.1021/ml200036r | 2011 | ACS Med Chem Lett | 2 | 466 | 470 | nan | nan | nan | nan | nan | nan |
CHEMBL1262706 | F | Antibacterial activity against mef(E)-positive Streptococcus pneumoniae isolate Spain 9V-3 by broth microdilution method | Streptococcus pneumoniae | 7 | 7 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | isolate Spain 9V-3 | Scientific Literature | 1313 | nan | nan | nan | nan | CHEMBL1255352 | 18362188 | 10.1128/aac.01487-07 | 2008 | Antimicrob Agents Chemother | 52 | 1964 | 1969 | nan | nan | nan | nan | nan | nan |
CHEMBL1010127 | F | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 by microplate alamar blue assay | Mycobacterium tuberculosis | 14 | 14 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | H37Rv | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1154486 | 18436347 | 10.1016/j.ejmech.2008.02.022 | 2009 | Eur J Med Chem | 44 | 289 | 295 | nan | nan | nan | nan | nan | nan |
CHEMBL741413 | F | Reduction in eosinophil count in murine asthma model tested in vivo by po administration at a dose of 10 mg/kg (peroral) | Mus musculus | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 10090 | nan | nan | nan | nan | CHEMBL1146634 | 14552799 | 10.1016/s0960-894x(03)00760-1 | 2003 | Bioorg Med Chem Lett | 13 | 3875 | 3878 | standard_type:DOSE standard_relation:= standard_value:10.0 standard_units:mg.kg-1 comments:None | standard_type:ROUTE standard_relation:None standard_value:None standard_units:None comments:None | nan | nan | nan | nan | nan |
CHEMBL706707 | F | Minimum inhibitory concentration required to reduce virus induced cytopathicity by 50% was determined against influenza B virus in MDCK cells | Canis lupus familiaris | 4 | 4 | BAO_0000219 | cell-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 9615 | nan | nan | MDCK | nan | CHEMBL1126305 | 1326633 | 10.1021/jm00096a012 | 1992 | J Med Chem | 35 | 3372 | 3377 | nan | nan | nan | nan | nan | nan |
CHEMBL798559 | A | In vivo biodistribution of [125I]QNP in the lung of female fisher VAF rats at 60 minutes | Rattus norvegicus | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 10116 | CHEMBL3638235 | Lung | nan | nan | CHEMBL1127012 | 8464039 | 10.1021/jm00059a009 | 1993 | J Med Chem | 36 | 848 | 854 | nan | nan | nan | nan | nan | nan |
CHEMBL1674895 | F | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae ATCC 6301 infected in iv dosed Swiss Webster mouse administered at 1 to 3 hrs post infection measured after 3 days | Streptococcus pneumoniae | 2 | 2 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | ATCC 6301 | Scientific Literature | 1313 | nan | nan | nan | nan | CHEMBL1671654 | 19273686 | 10.1128/aac.00833-08 | 2009 | Antimicrob Agents Chemother | 53 | 2028 | 2033 | nan | nan | nan | nan | nan | nan |
CHEMBL1930450 | F | Antituberculosis activity against Mycobacterium tuberculosis H37Rv by twofold serial dilution method | Mycobacterium tuberculosis | 23 | 23 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | H37Rv | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1926666 | 22153872 | 10.1016/j.bmc.2011.11.020 | 2012 | Bioorg Med Chem | 20 | 137 | 144 | nan | nan | nan | nan | nan | nan |
CHEMBL1245576 | F | Antibacterial activity against 1.5 x 10'7 CFU Streptococcus pneumoniae serotype 2 infected in semitherapeutic C57BL/6 mouse model assessed as reduction of bacteremia at 20 mg/kg, ip measured after 1 day post infection | Streptococcus pneumoniae | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | serotype 2 | Scientific Literature | 1313 | nan | nan | nan | nan | CHEMBL1240356 | 19917756 | 10.1128/aac.00943-09 | 2010 | Antimicrob Agents Chemother | 54 | 707 | 717 | standard_type:DOSE standard_relation:= standard_value:20.0 standard_units:mg.kg-1 comments:None | standard_type:ROUTE standard_relation:None standard_value:None standard_units:None comments:None | nan | nan | nan | nan | nan |
CHEMBL647671 | B | In vitro blocking of beta adrenergic receptor in guinea pig trachea | Cavia porcellus | 68 | 68 | BAO_0000221 | tissue-based format | 4 | 4 - Multiple homologous protein targets may be assigned | nan | Scientific Literature | 10141 | CHEMBL3638261 | Trachea | nan | nan | CHEMBL1122794 | 6146718 | 10.1021/jm00374a013 | 1984 | J Med Chem | 27 | 1007 | 1016 | nan | nan | nan | nan | nan | nan |
CHEMBL1671351 | F | Antimicrobial activity against erythromycin-resistant Streptococcus pneumoniae A22072 expressing the mef gene by broth microdilution method | Streptococcus pneumoniae | 36 | 36 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | A22072 | Scientific Literature | 1313 | nan | nan | nan | nan | CHEMBL1667745 | 21159410 | 10.1016/j.ejmech.2010.11.035 | 2011 | Eur J Med Chem | 46 | 556 | 566 | nan | nan | nan | nan | nan | nan |
CHEMBL747369 | B | Inhibitory activity against influenza neuraminidase (Influenza B/Lee/40) | Influenza B virus | 4 | 4 | BAO_0000357 | single protein format | 8 | 8 - Homologous single protein target assigned | nan | Scientific Literature | 11520 | nan | nan | nan | nan | CHEMBL1131761 | 10406636 | 10.1016/s0960-894x(99)00280-2 | 1999 | Bioorg Med Chem Lett | 9 | 1751 | 1756 | nan | nan | nan | nan | nan | nan |
CHEMBL1267641 | F | Antimicrobial activity against ampicillin resistant nontypeable Haemophilus influenzae isolate BB1050 harboring with plasmid pB1000 bearing beta-lactamase ROB-1 by broth microdilution method | Haemophilus influenzae | 9 | 9 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | isolate BB1050 | Scientific Literature | 727 | nan | nan | nan | nan | CHEMBL1255399 | 20086141 | 10.1128/aac.01489-09 | 2010 | Antimicrob Agents Chemother | 54 | 1506 | 1511 | nan | nan | nan | nan | nan | nan |
CHEMBL1267552 | F | Antimicrobial activity against Haemophilus influenzae Rd KW20 by broth microdilution method | Haemophilus influenzae | 9 | 9 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | Rd KW20 | Scientific Literature | 727 | nan | nan | nan | nan | CHEMBL1255399 | 20086141 | 10.1128/aac.01489-09 | 2010 | Antimicrob Agents Chemother | 54 | 1506 | 1511 | nan | nan | nan | nan | nan | nan |
CHEMBL1267644 | F | Antimicrobial activity against ampicillin resistant serotype-e Haemophilus influenzae isolate BB1053 harboring with plasmid pB1000 bearing beta-lactamase ROB-1 by broth microdilution method | Haemophilus influenzae | 9 | 9 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | isolate BB1053 | Scientific Literature | 727 | nan | nan | nan | nan | CHEMBL1255399 | 20086141 | 10.1128/aac.01489-09 | 2010 | Antimicrob Agents Chemother | 54 | 1506 | 1511 | nan | nan | nan | nan | nan | nan |
CHEMBL1267642 | F | Antimicrobial activity against ampicillin resistant nontypeable Haemophilus influenzae isolate BB1051 harboring with plasmid pB1000 bearing beta-lactamase ROB-1 by broth microdilution method | Haemophilus influenzae | 9 | 9 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | isolate BB1051 | Scientific Literature | 727 | nan | nan | nan | nan | CHEMBL1255399 | 20086141 | 10.1128/aac.01489-09 | 2010 | Antimicrob Agents Chemother | 54 | 1506 | 1511 | nan | nan | nan | nan | nan | nan |
CHEMBL1266817 | A | Drug level in plasma of patient scheduled to undergo fiber-optic bronchoscopy at 400 mg/kg, po administered during fasting condition measured on 2 to 3 hrs prior to bronchoscopy by LC-MS analysis | Homo sapiens | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 9606 | CHEMBL3559721 | Plasma | nan | nan | CHEMBL1255232 | 17485507 | 10.1128/aac.00736-06 | 2008 | Antimicrob Agents Chemother | 52 | 1945 | 1951 | standard_type:DOSE standard_relation:= standard_value:400.0 standard_units:mg.kg-1 comments:None | standard_type:ROUTE standard_relation:None standard_value:None standard_units:None comments:None | nan | nan | nan | nan | nan |
CHEMBL1262449 | F | Antibacterial activity against multidrug resistant Streptococcus pneumoniae ATCC 49619 assessed as resistant strains by CLSI microdilution susceptibility testing method | Streptococcus pneumoniae | 8 | 8 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | ATCC 49619 | Scientific Literature | 1313 | nan | nan | nan | nan | CHEMBL1255263 | 18180346 | 10.1128/aac.01387-07 | 2008 | Antimicrob Agents Chemother | 52 | 1147 | 1149 | nan | nan | nan | nan | nan | nan |
CHEMBL738355 | F | Antitumor activity against M109 tumor murine lung carcinoma infected mice after ip administration using DMSO an saline as vehicle at a dose of 25 mg/kg/inj; 1/6 mice cured | Mus musculus | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 10090 | nan | nan | nan | nan | CHEMBL1126512 | nan | 10.1016/S0960-894X(00)80348-0 | 1993 | Bioorg Med Chem Lett | 3 | 1357 | 1360 | standard_type:ROUTE standard_relation:None standard_value:None standard_units:None comments:None | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS | Carcinoma Oncology Models | Neoplasm Oncology Models | Carcinoma | Neoplasms | nan | nan |
CHEMBL1053796 | F | Upregulation of dnaK RNA expression in Mycobacterium tuberculosis H37Rv ATCC 27294 at 2 to 10 ug/ml after 6 hrs by microarray analysis | Mycobacterium tuberculosis | 3 | 3 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | H37Rv ATCC 27294 | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1151981 | 19093848 | 10.1021/np800572r | 2009 | J Nat Prod | 72 | 360 | 365 | nan | nan | nan | nan | nan | nan |
CHEMBL879419 | F | Tested for inhibition of oxygen uptake by the compound included in an extract of Klebsiella pneumoniae along with substrate 1 at the dose of 0.8 mM; No inhibition | Klebsiella pneumoniae | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 573 | nan | nan | nan | nan | CHEMBL1127917 | nan | 10.1016/S0960-894X(01)80528-X | 1994 | Bioorg Med Chem Lett | 4 | 1537 | 1538 | nan | nan | nan | nan | nan | nan |
CHEMBL1173838 | F | Antiviral activity against influenza B virus assessed as inhibition of viral replication | Influenza B virus | 6 | 6 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 11520 | nan | nan | nan | nan | CHEMBL1177817 | 20558062 | 10.1016/j.bmcl.2010.05.083 | 2010 | Bioorg Med Chem Lett | 20 | 4088 | 4090 | nan | nan | nan | nan | nan | nan |
CHEMBL711839 | B | Inhibition of [3H]LTD4 binding on guinea-pig lung membranes | Cavia porcellus | 24 | 38 | BAO_0000221 | tissue-based format | 9 | 9 - Direct single protein target assigned | nan | Scientific Literature | 10141 | CHEMBL3638235 | Lung | nan | Membrane | CHEMBL1128611 | nan | 10.1016/0960-894X(95)00265-U | 1995 | Bioorg Med Chem Lett | 5 | 1615 | 1620 | nan | nan | nan | nan | nan | nan |
CHEMBL1955531 | F | Antituberculosis activity against isoniazid-, rifampin-resistant Mycobacterium tuberculosis isolate D | Mycobacterium tuberculosis | 2 | 2 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | isolate D | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1949543 | 22326144 | 10.1016/j.ejmech.2012.01.011 | 2012 | Eur J Med Chem | 50 | 18 | 26 | nan | nan | nan | nan | nan | nan |
CHEMBL1955543 | F | Selectivity ratio of IC50 for human THP1 cells to MIC for INH-resistant Mycobacterium tuberculosis isolate B | nan | 2 | 2 | BAO_0000219 | cell-based format | 0 | 0 - Default value - Target unknown or has yet to be assigned | nan | Scientific Literature | nan | nan | nan | THP-1 | nan | CHEMBL1949543 | 22326144 | 10.1016/j.ejmech.2012.01.011 | 2012 | Eur J Med Chem | 50 | 18 | 26 | nan | nan | nan | nan | nan | nan |
CHEMBL979599 | F | Antimicrobial activity against Mycobacterium tuberculosis H160 by agar dilution method | Mycobacterium tuberculosis | 15 | 15 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1149760 | 17499886 | 10.1016/j.ejmech.2007.03.012 | 2008 | Eur J Med Chem | 43 | 210 | 221 | nan | nan | nan | nan | nan | nan |
CHEMBL752559 | F | Evaluated in vitro for antiproliferative activity against NYH cell lines derived from small cell lung cancer | Homo sapiens | 20 | 20 | BAO_0000219 | cell-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 9606 | nan | nan | NSCLC | nan | CHEMBL1130292 | nan | 10.1016/S0960-894X(97)10152-4 | 1997 | Bioorg Med Chem Lett | 7 | 3095 | 3100 | nan | nan | nan | nan | nan | nan |
CHEMBL1266067 | F | Antibacterial activity against Klebsiella pneumoniae isolate VA375 with blaKPC-3, qnrA1, blaTEM-1, blaSHV-11 genes by CLSI method | Klebsiella pneumoniae | 15 | 15 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | isolate VA375 | Scientific Literature | 573 | nan | nan | nan | nan | CHEMBL1255372 | 18426899 | 10.1128/aac.00158-08 | 2008 | Antimicrob Agents Chemother | 52 | 2680 | 2682 | nan | nan | nan | nan | nan | nan |
CHEMBL1265976 | F | Antibacterial activity against Streptococcus pneumoniae isolate OC6610 assessed as log reduction in bacterial growth at 2 times MIC measured at 6 hrs by time-kill assay | Streptococcus pneumoniae | 2 | 2 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | isolate OC6610 | Scientific Literature | 1313 | nan | nan | nan | nan | CHEMBL1255444 | 20176911 | 10.1128/aac.01374-09 | 2010 | Antimicrob Agents Chemother | 54 | 1955 | 1964 | nan | nan | nan | nan | nan | nan |
CHEMBL1046583 | F | Antiviral activity against influenza A virus H1N1:H3N2 infected in african MDCK cells at subtoxic concentration | Influenza A virus | 4 | 4 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | H1N1:H3N2 | Scientific Literature | 11320 | nan | nan | MDCK | nan | CHEMBL1154091 | 19535252 | 10.1016/j.bmc.2009.05.076 | 2009 | Bioorg Med Chem | 17 | 4961 | 4967 | nan | nan | nan | nan | nan | nan |
CHEMBL1016717 | F | Bactericidal activity against beta lactamase-negative ampicillin-resistant Haemophilus influenzae infected in kinetic model assessed as reduction in colony count at simulated free serum concentration of 400 mg, po bid after 8 hrs | Haemophilus influenzae | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 727 | nan | nan | nan | nan | CHEMBL1138533 | 17664320 | 10.1128/aac.01530-06 | 2007 | Antimicrob Agents Chemother | 51 | 3699 | 3706 | nan | nan | nan | nan | nan | nan |
CHEMBL1016724 | F | Bactericidal activity against beta lactamase-negative ampicillin-resistant Haemophilus influenzae infected in kinetic model assessed as reduction in colony count at simulated total serum concentration of 400 mg, po bid after 30 hrs | Haemophilus influenzae | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 727 | nan | nan | nan | nan | CHEMBL1138533 | 17664320 | 10.1128/aac.01530-06 | 2007 | Antimicrob Agents Chemother | 51 | 3699 | 3706 | nan | nan | nan | nan | nan | nan |
CHEMBL1002986 | B | Inhibition of full length Mycobacterium tuberculosis H37Rv recombinant carbonic anhydrase 3 expressed in Escherichia coli BL21 by stopped flow CO2 hydration assay | Mycobacterium tuberculosis H37Rv | 37 | 37 | BAO_0000019 | assay format | 0 | 0 - Default value - Target unknown or has yet to be assigned | nan | Scientific Literature | 83332 | nan | nan | nan | nan | CHEMBL1138443 | 19338333 | 10.1021/jm9003126 | 2009 | J Med Chem | 52 | 3116 | 3120 | nan | nan | nan | nan | nan | nan |
CHEMBL991324 | F | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv infected Swiss mouse assessed as reduction of bacterial count in lungs at 25 mg/kg 5 times weekly for 4 weeks | Mycobacterium tuberculosis | 2 | 2 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | H37Rv | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1143400 | 15591164 | 10.1126/science.1106753 | 2005 | Science | 307 | 223 | 227 | standard_type:DOSE standard_relation:= standard_value:25.0 standard_units:mg.kg-1 comments:None | nan | nan | nan | nan | nan |
CHEMBL955472 | F | Antibacterial activity against beta-lactamase nonproducing ampicillin resistant Haemophilus influenzae group IIc isolates with acrR baseC insertion mutation by broth microdilution method | Haemophilus influenzae | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 727 | nan | nan | nan | nan | CHEMBL1150802 | 17470649 | 10.1128/aac.00354-07 | 2007 | Antimicrob Agents Chemother | 51 | 2564 | 2573 | nan | nan | nan | nan | nan | nan |
CHEMBL1953145 | F | Antiviral activity against Influenza A virus (A/Vietnam/1194/2004(H5N1)) infected in MDCK cells assessed as inhibition of viral replication by plaque reduction assay | Influenza A virus (A/Vietnam/1194/2004(H5N1)) | 27 | 27 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 644788 | nan | nan | MDCK | nan | CHEMBL1949531 | 22226654 | 10.1016/j.bmcl.2011.12.076 | 2012 | Bioorg Med Chem Lett | 22 | 1415 | 1420 | nan | nan | nan | nan | nan | nan |
CHEMBL1827091 | F | Antitubercular activity against Mycobacterium tuberculosis | Mycobacterium tuberculosis | 44 | 44 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1821556 | 21755942 | 10.1021/jm1010644 | 2011 | J Med Chem | 54 | 5639 | 5659 | nan | nan | nan | nan | nan | nan |
CHEMBL631822 | A | Organ distribution in rat lung 2 hr after intravenous injection | Rattus norvegicus | 5 | 5 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 10116 | CHEMBL3638235 | Lung | nan | nan | CHEMBL1121543 | 7420357 | 10.1021/jm00184a012 | 1980 | J Med Chem | 23 | 1127 | 1130 | nan | nan | nan | nan | nan | nan |
CHEMBL715582 | F | Compound was tested for antiviral activity against Herpes Simplex virus Type-1(HFEM) in human lung fibroblasts (MRC-5) | Homo sapiens | 1 | 1 | BAO_0000219 | cell-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 9606 | nan | nan | MRC5 | nan | CHEMBL1123836 | 3040998 | 10.1021/jm00392a020 | 1987 | J Med Chem | 30 | 1636 | 1642 | nan | nan | nan | nan | nan | nan |
CHEMBL715942 | F | Compound was tested for antiviral activity against Herpes Simplex virus Type-1(18189) in human lung fibroblasts (MRC-5) | Homo sapiens | 1 | 1 | BAO_0000219 | cell-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 9606 | nan | nan | MRC5 | nan | CHEMBL1123836 | 3040998 | 10.1021/jm00392a020 | 1987 | J Med Chem | 30 | 1636 | 1642 | nan | nan | nan | nan | nan | nan |
CHEMBL1249102 | F | Antibacterial activity against drug resistant Mycobacterium tuberculosis containing phenotypic katG315 mutation assessed as cumulative microbial sensitivity by phenotypic drug susceptibility testing | Mycobacterium tuberculosis | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1240374 | 20008778 | 10.1128/aac.00964-09 | 2010 | Antimicrob Agents Chemother | 54 | 1075 | 1081 | nan | nan | nan | nan | nan | nan |
CHEMBL1267375 | F | Antimicrobial activity against Influenza A virus (A/Puerto Rico/8/34(H1N1)) infected in BALB/c mouse assessed as increase in mouse survival at 4.7 mg/kg, itn administered for 7 days before infection | Influenza A virus | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | A/Puerto Rico/8/1934(H1N1) | Scientific Literature | 11320 | nan | nan | nan | nan | CHEMBL1255395 | 20047917 | 10.1128/aac.01311-09 | 2010 | Antimicrob Agents Chemother | 54 | 1256 | 1264 | standard_type:DOSE standard_relation:= standard_value:4.7 standard_units:mg.kg-1 comments:None | nan | nan | nan | nan | nan |
CHEMBL1267154 | F | Antibacterial activity against vancomycin intermediate Staphylococcus aureus Mu50 infected in ddY mouse assessed as decrease in lung abscesses at 100 mg/kg, ip after 3 days | Staphylococcus aureus | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | Mu50 | Scientific Literature | 1280 | nan | nan | nan | nan | CHEMBL1255367 | 18391033 | 10.1128/aac.01532-07 | 2008 | Antimicrob Agents Chemother | 52 | 2163 | 2168 | standard_type:DOSE standard_relation:= standard_value:100.0 standard_units:mg.kg-1 comments:None | standard_type:ROUTE standard_relation:None standard_value:None standard_units:None comments:None | nan | nan | nan | nan | nan |
CHEMBL1267030 | F | Antibacterial activity against methicillin-resistant Staphylococcus aureus NUMR101 infected in ddY mouse assessed as viable bacteria in lungs at 100 mg/kg, ip administered 1 day postinfection (Rvb=8.42 +/- 0.50 log CFU/ml) | Staphylococcus aureus | 2 | 2 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | NUMR101 | Scientific Literature | 1280 | nan | nan | nan | nan | CHEMBL1255367 | 18391033 | 10.1128/aac.01532-07 | 2008 | Antimicrob Agents Chemother | 52 | 2163 | 2168 | standard_type:DOSE standard_relation:= standard_value:100.0 standard_units:mg.kg-1 comments:None | standard_type:ROUTE standard_relation:None standard_value:None standard_units:None comments:None | nan | nan | nan | nan | nan |
CHEMBL694707 | F | Minimum inhibitory concentration required for antiviral activity to reduce TK Varicella Zoster virus (VZV) (07/1) induced cytopathicity in human embryonic lung cells (HEL) | Homo sapiens | 14 | 14 | BAO_0000219 | cell-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 9606 | nan | nan | HEL | nan | CHEMBL1127647 | 8176708 | 10.1021/jm00035a010 | 1994 | J Med Chem | 37 | 1307 | 1311 | nan | nan | nan | nan | nan | nan |
CHEMBL940505 | F | Antimycobacterial activity against Mycobacterium tuberculosis H37Ra by microplate alamar blue assay | Mycobacterium tuberculosis | 6 | 6 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | H37Ra | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1150578 | 11277765 | 10.1021/np0004404 | 2001 | J Nat Prod | 64 | 385 | 388 | nan | nan | nan | nan | nan | nan |
CHEMBL1167757 | B | Inhibition of N-terminal histidine-tagged Mycobacterium tuberculosis PTPB expressed in Escherichia coli BL21 (DE3) after 45 mins by fluorescence assay | Mycobacterium tuberculosis | 1 | 1 | BAO_0000019 | assay format | 9 | 9 - Direct single protein target assigned | nan | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1165932 | 20462762 | 10.1016/j.bmc.2010.04.051 | 2010 | Bioorg Med Chem | 18 | 3783 | 3789 | nan | nan | nan | nan | nan | nan |
CHEMBL1670216 | F | Antimycobacterial activity against drug-sensitive Mycobacterium tuberculosis isolate 2 | Mycobacterium tuberculosis | 2 | 2 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | isolate 2 | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1667806 | 21232949 | 10.1016/j.bmcl.2010.12.084 | 2011 | Bioorg Med Chem Lett | 21 | 899 | 903 | nan | nan | nan | nan | nan | nan |
CHEMBL1670230 | F | Antimycobacterial activity against drug-sensitive Mycobacterium tuberculosis isolate 16 | Mycobacterium tuberculosis | 2 | 2 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | isolate 16 | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1667806 | 21232949 | 10.1016/j.bmcl.2010.12.084 | 2011 | Bioorg Med Chem Lett | 21 | 899 | 903 | nan | nan | nan | nan | nan | nan |
CHEMBL955549 | B | Inhibition of bocillin FL binding to penicillin-resistant Streptococcus pneumoniae OC 8819 penicillin-binding protein 2b | Streptococcus pneumoniae | 3 | 3 | BAO_0000019 | assay format | 0 | 0 - Default value - Target unknown or has yet to be assigned | nan | Scientific Literature | 1313 | nan | nan | nan | nan | CHEMBL1157359 | 17470659 | 10.1128/aac.00029-07 | 2007 | Antimicrob Agents Chemother | 51 | 2621 | 2624 | nan | nan | nan | nan | nan | nan |
CHEMBL956455 | A | Apparent volume of distribution in tuberculosis patient at 600 mg, po | Homo sapiens | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 9606 | nan | nan | nan | nan | CHEMBL1150797 | 17452486 | 10.1128/aac.01550-06 | 2007 | Antimicrob Agents Chemother | 51 | 2546 | 2551 | nan | nan | nan | nan | nan | nan |
CHEMBL1675484 | A | Biodistribution in trachea of BALB/cAnNCrlCrlj mouse at 0.5 umol/kg administered as [14C]labeled compound intranasally as single dose measured 0.25 hrs post dose by liquid scintillation counting | Mus musculus | 3 | 3 | BAO_0000218 | organism-based format | 0 | 0 - Default value - Target unknown or has yet to be assigned | BALB/cAnNCrlCrlj | Scientific Literature | 10090 | CHEMBL3638261 | Trachea | nan | nan | CHEMBL1671670 | 19687241 | 10.1128/aac.00731-09 | 2009 | Antimicrob Agents Chemother | 53 | 4845 | 4851 | nan | nan | nan | nan | nan | nan |
CHEMBL813786 | F | Compound was evaluated for inhibitory activity against Park S Streptococcus pneumoniae; No growth | Streptococcus pneumoniae | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 1313 | nan | nan | nan | nan | CHEMBL1130994 | 9871746 | 10.1016/s0960-894x(98)00204-2 | 1998 | Bioorg Med Chem Lett | 8 | 1261 | 1266 | nan | nan | nan | nan | nan | nan |
CHEMBL1655545 | F | Antimicrobial activity against Pseudomonas aeruginosa isolate 3020S obtained from cystic fibrosis patient by disk diffusion method | Pseudomonas aeruginosa | 9 | 9 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | isolate 3020S | Scientific Literature | 287 | nan | nan | nan | nan | CHEMBL1649198 | 19258280 | 10.1128/aac.01024-08 | 2009 | Antimicrob Agents Chemother | 53 | 1987 | 1997 | nan | nan | nan | nan | nan | nan |
CHEMBL1291402 | F | Antiviral activity against influenza B virus infected in MDCK cells assessed as cell viability at 100 ug/ml after 2 days by MTS assay | Influenza B virus | 12 | 12 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 11520 | nan | nan | MDCK | nan | CHEMBL1287642 | 20724039 | 10.1016/j.ejmech.2010.07.058 | 2010 | Eur J Med Chem | 45 | 5474 | 5479 | nan | nan | nan | nan | nan | nan |
CHEMBL1264786 | F | Antimicrobial activity against Pseudomonas aeruginosa isolate 1693c from fibrosis patient by Etest | Pseudomonas aeruginosa | 10 | 10 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | isolate 1693c | Scientific Literature | 287 | nan | nan | nan | nan | CHEMBL1255447 | 20194693 | 10.1128/aac.00816-09 | 2010 | Antimicrob Agents Chemother | 54 | 2219 | 2224 | nan | nan | nan | nan | nan | nan |
CHEMBL1264790 | F | Antimicrobial activity against Pseudomonas aeruginosa isolate 1247c from fibrosis patient by Etest | Pseudomonas aeruginosa | 10 | 10 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | isolate 1247c | Scientific Literature | 287 | nan | nan | nan | nan | CHEMBL1255447 | 20194693 | 10.1128/aac.00816-09 | 2010 | Antimicrob Agents Chemother | 54 | 2219 | 2224 | nan | nan | nan | nan | nan | nan |
CHEMBL1658954 | F | Antiviral activity against Influenza A virus (A/Vietnam/1203/2004 (H5N1)) harboring hemagglutininin A45S, K156E, P210Q, L313F mutant gene and neuraminidase H274Y mutant infected in MDCK cells selected at 781 uM of oseltamivir after 10 passage after 48 hrs by hemagglutininin titer assay | Influenza A virus (A/environment/Viet Nam/1203/2004(H5N1)) | 2 | 2 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 680789 | nan | nan | MDCK | nan | CHEMBL1649232 | 19651908 | 10.1128/aac.00334-09 | 2009 | Antimicrob Agents Chemother | 53 | 4433 | 4440 | nan | nan | nan | nan | nan | nan |
CHEMBL1932120 | F | Antibacterial activity against Streptococcus pneumoniae 1629 after 18 to 24 hrs by broth microdilution technique | Streptococcus pneumoniae | 13 | 13 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | 1629 | Scientific Literature | 1313 | nan | nan | nan | nan | CHEMBL1926622 | 22030032 | 10.1016/j.bmcl.2011.09.114 | 2011 | Bioorg Med Chem Lett | 21 | 7483 | 7488 | nan | nan | nan | nan | nan | nan |
CHEMBL1281152 | F | Antimicrobial activity against aac(6')-Ib-cr-positive Klebsiella pneumoniae SY26 harboring GyrA S83I, ParC S80I mutant, wild-type GyrB and qnrB genes by agar dilution method | Klebsiella pneumoniae | 10 | 10 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | SY26 | Scientific Literature | 573 | nan | nan | nan | nan | CHEMBL1275556 | 18809939 | 10.1128/aac.00830-08 | 2008 | Antimicrob Agents Chemother | 52 | 4268 | 4273 | nan | nan | nan | nan | nan | nan |
CHEMBL1936489 | F | Antibacterial activity against Klebsiella pneumoniae after 24 hrs by microdilution method | Klebsiella pneumoniae | 22 | 22 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 573 | nan | nan | nan | nan | CHEMBL1932971 | 22209564 | 10.1016/j.ejmech.2011.12.012 | 2012 | Eur J Med Chem | 48 | 179 | 191 | nan | nan | nan | nan | nan | nan |
CHEMBL857222 | F | In vitro antibacterial activity of compound against Haemophilus influenzae ATCC 49247 was determined | Haemophilus influenzae | 4 | 4 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 727 | nan | nan | nan | nan | CHEMBL1130484 | nan | 10.1016/S0960-894X(97)00326-0 | 1997 | Bioorg Med Chem Lett | 7 | 1857 | 1862 | nan | nan | nan | nan | nan | nan |
CHEMBL1662845 | B | Displacement of Biocillin FL from Streptococcus pneumoniae 3243 PBP2A | Streptococcus pneumoniae | 5 | 5 | BAO_0000019 | assay format | 0 | 0 - Default value - Target unknown or has yet to be assigned | 3243 | Scientific Literature | 1313 | nan | nan | nan | nan | CHEMBL1649182 | 19237649 | 10.1128/aac.01566-08 | 2009 | Antimicrob Agents Chemother | 53 | 2176 | 2180 | nan | nan | nan | nan | nan | nan |
CHEMBL1831408 | F | Ratio of erythromycin-A MIC to compound MIC for erythromycin-resistant Streptococcus pneumoniae A22072 expressing mef gene | Streptococcus pneumoniae | 3 | 3 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | A22072 | Scientific Literature | 1313 | nan | nan | nan | nan | CHEMBL1828549 | 21855183 | 10.1016/j.ejmech.2011.08.001 | 2011 | Eur J Med Chem | 46 | 5196 | 5205 | nan | nan | nan | nan | nan | nan |
CHEMBL1167758 | B | Inhibition of Mycobacterium tuberculosis PTPA-mediated pNPP hydrolysis | Mycobacterium tuberculosis | 5 | 5 | BAO_0000357 | single protein format | 9 | 9 - Direct single protein target assigned | nan | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1165932 | 20462762 | 10.1016/j.bmc.2010.04.051 | 2010 | Bioorg Med Chem | 18 | 3783 | 3789 | nan | nan | nan | nan | nan | nan |
CHEMBL1059751 | F | Antibacterial activity against Haemophilus influenzae ATCC 49247 by agar dilution method | Haemophilus influenzae | 28 | 28 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | ATCC 49247 | Scientific Literature | 727 | nan | nan | nan | nan | CHEMBL1153012 | 19376613 | 10.1016/j.ejmech.2009.03.024 | 2009 | Eur J Med Chem | 44 | 3217 | 3227 | nan | nan | nan | nan | nan | nan |
CHEMBL1931815 | B | Competitive inhibition of Mycobacterium tuberculosis TMPK by Lineweaver-Burk analysis | Mycobacterium tuberculosis | 18 | 18 | BAO_0000357 | single protein format | 9 | 9 - Direct single protein target assigned | nan | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1926583 | 22061826 | 10.1016/j.bmc.2011.10.021 | 2011 | Bioorg Med Chem | 19 | 7603 | 7611 | nan | nan | nan | nan | nan | nan |
CHEMBL1245271 | F | Antibacterial activity against macrolide-resistant Streptococcus pneumoniae harboring mef(A) gene after overnight incubation by agar dilution method | Streptococcus pneumoniae | 9 | 18 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 1313 | nan | nan | nan | nan | CHEMBL1240350 | 19884376 | 10.1128/aac.01123-09 | 2010 | Antimicrob Agents Chemother | 54 | 230 | 238 | nan | nan | nan | nan | nan | nan |
CHEMBL1245259 | F | Antibacterial activity against penicillin-intermediate Streptococcus pneumoniae after overnight incubation by agar dilution method | Streptococcus pneumoniae | 9 | 18 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 1313 | nan | nan | nan | nan | CHEMBL1240350 | 19884376 | 10.1128/aac.01123-09 | 2010 | Antimicrob Agents Chemother | 54 | 230 | 238 | nan | nan | nan | nan | nan | nan |
CHEMBL1063022 | F | Antimicrobial activity against Mycobacterium tuberculosis H37Rv by microplate Alamar blue assay | Mycobacterium tuberculosis | 12 | 12 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | H37Rv | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1152337 | 19371071 | 10.1021/np800751j | 2009 | J Nat Prod | 72 | 894 | 899 | nan | nan | nan | nan | nan | nan |
CHEMBL1266535 | F | Antimicrobial activity against CTX-M-59 producing Klebsiella pneumoniae with PFGE pulsotype E by Etest in presence of clavulanic acid | Klebsiella pneumoniae | 2 | 2 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 573 | nan | nan | nan | nan | CHEMBL1255347 | 18347108 | 10.1128/aac.01440-07 | 2008 | Antimicrob Agents Chemother | 52 | 1790 | 1793 | nan | nan | nan | nan | nan | nan |
CHEMBL1107390 | F | Selectivity index, ratio of IC50 for african green monkey Vero cells to MIC for Mycobacterium tuberculosis Erdman | nan | 1 | 1 | BAO_0000219 | cell-based format | 0 | 0 - Default value - Target unknown or has yet to be assigned | nan | Scientific Literature | nan | nan | nan | Vero | nan | CHEMBL1157082 | 20218656 | 10.1021/np900674d | 2010 | J Nat Prod | 73 | 563 | 567 | nan | nan | nan | nan | nan | nan |
CHEMBL1947402 | F | Antimicrobial activity against Mycobacterium tuberculosis infected in BALB/c mouse assessed as fold reduction in lung CFU at 100 mg/kg, po administered 11 days after post infection qd for 5 days per week for 3 weeks relative to PA-824 | Mycobacterium tuberculosis | 11 | 11 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1944507 | 22148391 | 10.1021/jm2012276 | 2012 | J Med Chem | 55 | 312 | 326 | standard_type:DOSE standard_relation:= standard_value:100.0 standard_units:mg.kg-1 comments:None | standard_type:ROUTE standard_relation:None standard_value:None standard_units:None comments:None | nan | nan | nan | nan | nan |
CHEMBL1266679 | A | AUC (0 to 24 hrs) in CSF of patient with intracerebral and leptomeningeal tuberculosis at 400 mg/kg, po QD measured on day 3 | Homo sapiens | 1 | 1 | BAO_0000218 | organism-based format | 0 | 0 - Default value - Target unknown or has yet to be assigned | nan | Scientific Literature | 9606 | CHEMBL3638212 | Cerebrospinal fluid | nan | nan | CHEMBL1255350 | 18362186 | 10.1128/aac.01637-07 | 2008 | Antimicrob Agents Chemother | 52 | 2293 | 2295 | standard_type:DOSE standard_relation:= standard_value:400.0 standard_units:mg.kg-1 comments:None | standard_type:ROUTE standard_relation:None standard_value:None standard_units:None comments:None | nan | nan | nan | nan | nan |
CHEMBL697337 | B | Compound tested for specific activity against rabbit lung Indoleethylamine-N-methyltransferase at oral dose of 20 mg/kg | Oryctolagus cuniculus | 1 | 1 | BAO_0000218 | organism-based format | 8 | 8 - Homologous single protein target assigned | nan | Scientific Literature | 9986 | nan | nan | nan | nan | CHEMBL1121475 | 7401104 | 10.1021/jm00181a014 | 1980 | J Med Chem | 23 | 773 | 780 | standard_type:DOSE standard_relation:= standard_value:20.0 standard_units:mg.kg-1 comments:None | standard_type:ROUTE standard_relation:None standard_value:None standard_units:None comments:None | nan | nan | nan | nan | nan |
CHEMBL691327 | F | Percent inhibition of the LTE4- induced contraction of guinea pig tracheal spirals at the concentration of 3.3 uM | Cavia porcellus | 9 | 9 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 10141 | CHEMBL3638261 | Trachea | nan | nan | CHEMBL1125163 | 2342071 | 10.1021/jm00168a036 | 1990 | J Med Chem | 33 | 1771 | 1781 | nan | RESPIRATORY SYSTEM | Effects on Air Ways | Bronchospasmolytic Activity in Anesthetized Guinea Pigs (Konzett Rossler method) | nan | nan |
CHEMBL1104484 | F | Selectivity index, ratio of IC50 for african green monkey Vero cells to MIC for Mycobacterium tuberculosis H37Rv ATCC 27294 by microplate alamar blue assay | nan | 19 | 19 | BAO_0000219 | cell-based format | 0 | 0 - Default value - Target unknown or has yet to be assigned | nan | Scientific Literature | nan | nan | nan | Vero | nan | CHEMBL1156236 | 20356752 | 10.1016/j.bmc.2010.03.018 | 2010 | Bioorg Med Chem | 18 | 2880 | 2886 | nan | nan | nan | nan | nan | nan |
CHEMBL1693410 | F | Antimicrobial activity against Pseudomonas aeruginosa isolate 4 obtained from cystic fibrosis patients after 16 to 20 hrs by broth microdilution method in presence of 120 uM carbonyl cyanide m-chlorophenyl-hydrazone | Pseudomonas aeruginosa | 3 | 3 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | isolate 4 | Scientific Literature | 287 | nan | nan | nan | nan | CHEMBL1687785 | 20713660 | 10.1128/aac.00009-10 | 2010 | Antimicrob Agents Chemother | 54 | 4772 | 4779 | nan | nan | nan | nan | nan | nan |
CHEMBL1040361 | F | Antimycobacterial activity against multidrug resistant Mycobacterium tuberculosis at 10 ug/ml after 72 hrs by LRP assay | Mycobacterium tuberculosis | 11 | 11 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1154054 | 19464085 | 10.1016/j.ejmech.2009.04.023 | 2009 | Eur J Med Chem | 44 | 3954 | 3960 | nan | nan | nan | nan | nan | nan |
CHEMBL1693327 | F | Effect on cellular respiration in human T47D cells assessed as oxygen consumption at 0.3 uM by cell-based reporter assay | Homo sapiens | 7 | 7 | BAO_0000219 | cell-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 9606 | nan | nan | T47D | nan | CHEMBL1687858 | 21214226 | 10.1021/np100762s | 2011 | J Nat Prod | 74 | 240 | 248 | nan | nan | nan | nan | nan | nan |
CHEMBL1662137 | F | Antimicrobial activity against multidrug resistant Klebsiella pneumoniae isolate 14 by broth dilution method | Klebsiella pneumoniae | 8 | 8 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | isolate 14 | Scientific Literature | 573 | nan | nan | nan | nan | CHEMBL1649134 | 19164140 | 10.1128/aac.00822-08 | 2009 | Antimicrob Agents Chemother | 53 | 1652 | 1656 | nan | nan | nan | nan | nan | nan |
CHEMBL1262977 | F | Antibacterial activity against amoxicillin-clavulanic acid resistant Streptococcus pneumoniae by microdilution method | Streptococcus pneumoniae | 1 | 2 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 1313 | nan | nan | nan | nan | CHEMBL1255272 | 18180358 | 10.1128/aac.01332-07 | 2008 | Antimicrob Agents Chemother | 52 | 1182 | 1183 | nan | nan | nan | nan | nan | nan |
CHEMBL1265973 | F | Antibacterial activity against Streptococcus pneumoniae isolate OC6585 assessed as log reduction in bacterial growth at 2 times MIC measured at 24 hrs by time-kill assay | Streptococcus pneumoniae | 2 | 2 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | isolate OC6585 | Scientific Literature | 1313 | nan | nan | nan | nan | CHEMBL1255444 | 20176911 | 10.1128/aac.01374-09 | 2010 | Antimicrob Agents Chemother | 54 | 1955 | 1964 | nan | nan | nan | nan | nan | nan |
CHEMBL718293 | F | Antiviral activity of compound was tested against influenza B,H1N1 virus infected MDCK cell lines | Canis lupus familiaris | 4 | 4 | BAO_0000219 | cell-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 9615 | nan | nan | MDCK | nan | CHEMBL1129609 | 8765514 | 10.1021/jm950891z | 1996 | J Med Chem | 39 | 3307 | 3318 | nan | nan | nan | nan | nan | nan |
CHEMBL1227843 | F | Antiviral activity against Influenza B virus Florida/4/2006 infected in MDCK cells assessed as reduction of viral yeild | Influenza B virus | 2 | 2 | BAO_0000219 | cell-based format | 1 | 1 - Target assigned is non-molecular | B/Florida/4/2006 | Scientific Literature | 11520 | nan | nan | MDCK | nan | CHEMBL1221294 | 20674371 | 10.1016/j.bmc.2010.07.017 | 2010 | Bioorg Med Chem | 18 | 6329 | 6339 | nan | nan | nan | nan | nan | nan |
CHEMBL1246202 | F | Antitubercular activity against Mycobacterium tuberculosis ATCC 35801 infected in CD1 mouse lung at 25 mg/kg, iv after 6 weeks | Mycobacterium tuberculosis | 30 | 30 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | ATCC 35801 | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1240433 | 20576327 | 10.1016/j.ejmech.2010.05.035 | 2010 | Eur J Med Chem | 45 | 3831 | 3839 | standard_type:DOSE standard_relation:= standard_value:25.0 standard_units:mg.kg-1 comments:None | standard_type:ROUTE standard_relation:None standard_value:None standard_units:None comments:None | nan | nan | nan | nan | nan |
CHEMBL1041105 | F | Antimycobacterial activity against rifampicin-resistant Mycobacterium tuberculosis ATCC 35838 by twofold agar dilution method | Mycobacterium tuberculosis | 11 | 11 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | ATCC 35838 | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1155279 | 19595488 | 10.1016/j.ejmech.2009.06.005 | 2009 | Eur J Med Chem | 44 | 4734 | 4738 | nan | nan | nan | nan | nan | nan |
CHEMBL1246805 | F | Antitubercular activity against Mycobacterium tuberculosis ATCC 35801 infected in CD1 mouse spleen at 25 mg/kg, iv after 6 weeks | Mycobacterium tuberculosis | 30 | 30 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | ATCC 35801 | Scientific Literature | 1773 | CHEMBL3559722 | Spleen | nan | nan | CHEMBL1240433 | 20576327 | 10.1016/j.ejmech.2010.05.035 | 2010 | Eur J Med Chem | 45 | 3831 | 3839 | standard_type:DOSE standard_relation:= standard_value:25.0 standard_units:mg.kg-1 comments:None | standard_type:ROUTE standard_relation:None standard_value:None standard_units:None comments:None | nan | nan | nan | nan | nan |
CHEMBL619737 | A | Biodistribution of [123I]-label in rat lung was reported at 1 hr post injection. Value shown is %ID/g of tissue | Rattus norvegicus | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 10116 | CHEMBL3638235 | Lung | nan | nan | CHEMBL1130041 | 9171875 | 10.1021/jm960720+ | 1997 | J Med Chem | 40 | 1657 | 1667 | nan | nan | nan | nan | nan | nan |
CHEMBL1248985 | F | Ratio of AUC to MIC for Acinetobacter baumannii 1327 in pharmacokinetic-pharmacodynamic C57BL/6 mouse pneumonia model at 12 mg/kg, im | nan | 1 | 1 | BAO_0000218 | organism-based format | 0 | 0 - Default value - Target unknown or has yet to be assigned | nan | Scientific Literature | nan | nan | nan | nan | nan | CHEMBL1240392 | 20047914 | 10.1128/aac.00367-09 | 2010 | Antimicrob Agents Chemother | 54 | 1165 | 1172 | standard_type:DOSE standard_relation:= standard_value:12.0 standard_units:mg.kg-1 comments:None | standard_type:ROUTE standard_relation:None standard_value:None standard_units:None comments:None | nan | nan | nan | nan | nan |
CHEMBL624713 | F | In vitro cytotoxicity against A549 (human lung carcinoma) cell line. | Homo sapiens | 17 | 18 | BAO_0000219 | cell-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 9606 | nan | nan | A549 | nan | CHEMBL1127617 | 7914927 | 10.1021/jm00043a005 | 1994 | J Med Chem | 37 | 2655 | 2663 | nan | nan | nan | nan | nan | nan |
CHEMBL1687502 | F | Antitubercular activity against multidrug-resistant Mycobacterium tuberculosis H37Rv after 7 days by alamar blue assay | Mycobacterium tuberculosis | 50 | 50 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | H37Rv | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1681637 | 21277200 | 10.1016/j.bmcl.2010.12.128 | 2011 | Bioorg Med Chem Lett | 21 | 1515 | 1518 | nan | nan | nan | nan | nan | nan |
CHEMBL1247075 | F | Antimicrobial activity against Klebsiella pneumoniae clinical isolate assessed as resistance isolates by disk diffusion method | Klebsiella pneumoniae | 2 | 2 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 573 | nan | nan | nan | nan | CHEMBL1240398 | 20065055 | 10.1128/aac.01076-09 | 2010 | Antimicrob Agents Chemother | 54 | 1173 | 1178 | nan | nan | nan | nan | nan | nan |
CHEMBL1266064 | F | Antibacterial activity against Klebsiella pneumoniae isolate VA367 with blaKPC-3, qnrB19, blaTEM-1, blaSHV-11, blaSHV-12, aac(6')-1b genes by Etest method | Klebsiella pneumoniae | 5 | 5 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | isolate VA367 | Scientific Literature | 573 | nan | nan | nan | nan | CHEMBL1255372 | 18426899 | 10.1128/aac.00158-08 | 2008 | Antimicrob Agents Chemother | 52 | 2680 | 2682 | nan | nan | nan | nan | nan | nan |
CHEMBL635847 | A | Evaluated for biodistribution in rat lung after 1 min of administration | Rattus norvegicus | 4 | 4 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 10116 | CHEMBL3638235 | Lung | nan | nan | CHEMBL1122101 | 7108905 | 10.1021/jm00349a022 | 1982 | J Med Chem | 25 | 870 | 873 | nan | nan | nan | nan | nan | nan |
CHEMBL1033297 | F | Cytotoxicity against human lung cancer cells | Homo sapiens | 8 | 8 | BAO_0000219 | cell-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 9606 | nan | nan | Cancer cell lines | nan | CHEMBL1137805 | 11473418 | 10.1021/np000554f | 2001 | J Nat Prod | 64 | 896 | 898 | nan | nan | nan | nan | nan | nan |
CHEMBL1250673 | F | Antibacterial activity against streptomycin-resistant Mycobacterium tuberculosis after 7 days by microplate alamar blue assay | Mycobacterium tuberculosis | 11 | 11 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1250546 | 20833056 | 10.1016/j.bmc.2010.08.016 | 2010 | Bioorg Med Chem | 18 | 7274 | 7282 | nan | nan | nan | nan | nan | nan |
CHEMBL694532 | F | Dose for reversal of keratinization in epithelium of 50% of retinoid-deficient hamster tracheas in organ culture | Cricetulus griseus | 3 | 3 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 10029 | CHEMBL3638261 | Trachea | nan | nan | CHEMBL1123088 | 2578190 | 10.1021/jm00379a021 | 1985 | J Med Chem | 28 | 116 | 124 | nan | nan | nan | nan | nan | nan |
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