ChEMBL ID
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CHEMBL2114731 | F | PubChem BioAssay. Mycobacterium tuberculosis BioA enzyme inhibitor Measured in Biochemical System Using Plate Reader - 2163-03_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) | Mycobacterium tuberculosis UT205 | nan | nan | BAO_0000217 | biochemical format | 8 | 8 - Homologous single protein target assigned | nan | PubChem BioAssays | 1097669 | nan | nan | nan | nan | CHEMBL1201862 | nan | nan | nan | nan | nan | nan | nan | nan | nan | nan | nan | nan | nan |
CHEMBL3832909 | F | Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063; Growth inhibition at 20 uM in CAMBH media using NBS plates. | Klebsiella pneumoniae | nan | nan | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | ATCC 700603; MDR | CO-ADD antimicrobial screening data | 573 | nan | nan | nan | nan | CHEMBL3832881 | nan | 10.6019/CHEMBL3832881 | nan | nan | nan | nan | nan | standard_type:ASSAY_TEST standard_relation:None standard_value:None standard_units:None comments:None | standard_type:CONC standard_relation:= standard_value:20.0 standard_units:uM comments:None | standard_type:DETECTION_METHOD standard_relation:None standard_value:None standard_units:None comments:None | standard_type:MEDIA standard_relation:None standard_value:None standard_units:None comments:None | standard_type:PLATE_TYPE standard_relation:None standard_value:None standard_units:None comments:None | standard_type:TIME standard_relation:= standard_value:18.0 standard_units:hr comments:None | nan | nan | nan | nan | nan |
CHEMBL1667530 | F | Antimicrobial activity against Klebsiella pneumoniae isolate M2 harboring qnrS1 gene by agar dilution method | Klebsiella pneumoniae | 3 | 3 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | isolate M2 | Scientific Literature | 573 | nan | nan | nan | nan | CHEMBL1649485 | 19364872 | 10.1128/aac.01722-08 | 2009 | Antimicrob Agents Chemother | 53 | 2632 | 2635 | nan | nan | nan | nan | nan | nan |
CHEMBL997700 | F | Antitubercular activity against Mycobacterium tuberculosis H37Rv after 4 days by microplate alamar blue assay | Mycobacterium tuberculosis | 25 | 25 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | H37Rv | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1141707 | 18774716 | 10.1016/j.bmcl.2008.08.027 | 2008 | Bioorg Med Chem Lett | 18 | 5311 | 5315 | nan | nan | nan | nan | nan | nan |
CHEMBL974548 | F | Antibacterial activity against Streptococcus pneumoniae ATCC 49619 after 24 hrs by twofold serial dilution method | Streptococcus pneumoniae | 10 | 10 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 1313 | nan | nan | nan | nan | CHEMBL1155937 | 18650090 | 10.1016/j.bmcl.2008.07.007 | 2008 | Bioorg Med Chem Lett | 18 | 4678 | 4681 | nan | nan | nan | nan | nan | nan |
CHEMBL1803418 | F | Antibacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 after 14 days by microplate alamar blue assay | Mycobacterium tuberculosis | 12 | 12 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | H37Rv ATCC 27294 | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1800046 | 21678907 | 10.1021/jm2000085 | 2011 | J Med Chem | 54 | 4964 | 4976 | nan | nan | nan | nan | nan | nan |
CHEMBL1168598 | F | Antibacterial activity against Mycobacterium tuberculosis H37Rv infected in human THP1 cells assessed as reduction of bacterial burden at 20 uM after 48 hrs | Mycobacterium tuberculosis | 5 | 5 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | H37Rv | Scientific Literature | 1773 | nan | nan | THP-1 | nan | CHEMBL1165932 | 20462762 | 10.1016/j.bmc.2010.04.051 | 2010 | Bioorg Med Chem | 18 | 3783 | 3789 | nan | nan | nan | nan | nan | nan |
CHEMBL1104781 | F | Antimycobacterial activity against isoniazid-resistant Mycobacterium tuberculosis H37Rv at 2 ug/ml by radiometric BACTEC assay | Mycobacterium tuberculosis | 2 | 2 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | H37Rv | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1157790 | 20420370 | 10.1021/jm100165w | 2010 | J Med Chem | 53 | 4130 | 4140 | nan | nan | nan | nan | nan | nan |
CHEMBL993640 | F | Antibacterial activity against carbapenem-resistant Klebsiella pneumoniae 490 isolate producing KPC3 and TEM1 carbapenemases | Klebsiella pneumoniae | 12 | 12 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 573 | nan | nan | nan | nan | CHEMBL1155771 | 17562800 | 10.1128/aac.00299-07 | 2007 | Antimicrob Agents Chemother | 51 | 3026 | 3029 | nan | nan | nan | nan | nan | nan |
CHEMBL813025 | F | In vitro antibacterial activity against erythromycin susceptible Streptococcus pneumoniae 49619 | Streptococcus pneumoniae | 6 | 6 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 1313 | nan | nan | nan | nan | CHEMBL1148318 | 15163176 | 10.1021/jm034233n | 2004 | J Med Chem | 47 | 2965 | 2968 | nan | nan | nan | nan | nan | nan |
CHEMBL858368 | F | The compound was tested in vitro for minimum inhibitory concentration against Klebsiella pneumoniae A | Klebsiella pneumoniae | 12 | 12 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 573 | nan | nan | nan | nan | CHEMBL1125212 | 1910090 | 10.1021/jm00113a026 | 1991 | J Med Chem | 34 | 2857 | 2864 | nan | nan | nan | nan | nan | nan |
CHEMBL924559 | F | Antimicrobial activity against Streptococcus pneumoniae | Streptococcus pneumoniae | 2 | 2 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 1313 | nan | nan | nan | nan | CHEMBL1145519 | 17568739 | 10.1038/nature05689 | 2007 | Nature | 447 | 817 | 822 | nan | nan | nan | nan | nan | nan |
CHEMBL1119065 | F | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv under dormancy-inducing hypoxic condition | Mycobacterium tuberculosis | 4 | 4 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | H37Rv | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1158611 | 20483615 | 10.1016/j.bmcl.2010.04.100 | 2010 | Bioorg Med Chem Lett | 20 | 3658 | 3663 | nan | nan | nan | nan | nan | nan |
CHEMBL1281324 | F | Antimicrobial activity against aac(6')-Ib-cr-positive Klebsiella pneumoniae WH99 harboring wild-type GyrA, ParC, GyrB and qnrB genes by agar dilution method | Klebsiella pneumoniae | 10 | 10 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | WH99 | Scientific Literature | 573 | nan | nan | nan | nan | CHEMBL1275556 | 18809939 | 10.1128/aac.00830-08 | 2008 | Antimicrob Agents Chemother | 52 | 4268 | 4273 | nan | nan | nan | nan | nan | nan |
CHEMBL700148 | F | Compound was evaluated for in vitro antibacterial activity against gram negative organism Klebsiella pneumoniae strain ATCC 10031 | Klebsiella pneumoniae | 10 | 10 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 573 | nan | nan | nan | nan | CHEMBL1131559 | 9871611 | 10.1016/s0960-894x(98)00063-8 | 1998 | Bioorg Med Chem Lett | 8 | 525 | 528 | nan | nan | nan | nan | nan | nan |
CHEMBL1831620 | F | Antimicrobial activity against non-replicating Mycobacterium tuberculosis | Mycobacterium tuberculosis | 2 | 2 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1828542 | 21783364 | 10.1016/j.bmcl.2011.06.076 | 2011 | Bioorg Med Chem Lett | 21 | 5589 | 5593 | nan | nan | nan | nan | nan | nan |
CHEMBL1216576 | F | Antibacterial activity against macrolide-resistant Haemophilus influenzae 4437 infected in NCI-H292 cells assessed as decrease in viable bacterial count at 64 ug/ml by 3-h invasion assay | Haemophilus influenzae | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | 4437 | Scientific Literature | 727 | nan | nan | NCI-H292 | nan | CHEMBL1212794 | 19949056 | 10.1128/aac.00524-09 | 2010 | Antimicrob Agents Chemother | 54 | 757 | 762 | nan | nan | nan | nan | nan | nan |
CHEMBL1679851 | F | Antimicrobial activity against Pseudomonas aeruginosa isolate PA22 obtained from patient with cystic fibrosis harboring beta-lactamase AmpD1 Gly148ala and Asp183Tyr mutant by disk diffusion method | Pseudomonas aeruginosa | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | isolate PA22 | Scientific Literature | 287 | nan | nan | nan | nan | CHEMBL1671636 | 18779353 | 10.1128/aac.00341-08 | 2008 | Antimicrob Agents Chemother | 52 | 3922 | 3927 | nan | nan | nan | nan | nan | nan |
CHEMBL1675233 | F | Antibacterial activity against ROB-1 producing ICE- negative Haemophilus influenzae Rd transformant harboring plasmid PB1000 by broth microdilution method | Haemophilus influenzae | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | Rd | Scientific Literature | 727 | nan | nan | nan | nan | CHEMBL1671749 | 20713676 | 10.1128/aac.00263-10 | 2010 | Antimicrob Agents Chemother | 54 | 4945 | 4947 | nan | nan | nan | nan | nan | nan |
CHEMBL875635 | A | Radioactivity was determined in lung tissues of female fischer 344 rats by intravenous administration after 2 hours | Rattus norvegicus | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 10116 | CHEMBL3638235 | Lung | nan | nan | CHEMBL1122968 | 3981533 | 10.1021/jm00382a003 | 1985 | J Med Chem | 28 | 408 | 413 | nan | nan | nan | nan | nan | nan |
CHEMBL1068293 | F | Antiviral activity against human influenza A virus A/WSN/33 (H1N1) in MDCK cells assessed as reduction of virus-induced cytopathic effect | Influenza A virus | 66 | 66 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | A/WSN/1933(H1N1) | Scientific Literature | 11320 | nan | nan | MDCK | nan | CHEMBL1156875 | 20092255 | 10.1021/jm901570x | 2010 | J Med Chem | 53 | 1519 | 1533 | nan | nan | nan | nan | nan | nan |
CHEMBL1676813 | F | Antiviral activity against Influenza A virus (A/Washington/29/2009(H1N1)) infected in MDCK cells from Mill Hill assessed as log reduction in viral titer at 128 uM after 24 hrs by immunofluorescent assay | Influenza A virus (A/Washington/29/2009(H1N1)) | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 667723 | nan | nan | MDCK | nan | CHEMBL1671691 | 20350949 | 10.1128/aac.01739-09 | 2010 | Antimicrob Agents Chemother | 54 | 2517 | 2524 | nan | nan | nan | nan | nan | nan |
CHEMBL1676693 | F | Antibacterial activity against 7.5 x 10'8 CFU Haemophilus influenzae hd2 infected in ICR mouse systemic infection model assessed as mouse protection administered orally twice after 1 and 4 hrs post infection measured after 48 hrs | Haemophilus influenzae | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | hd2 | Scientific Literature | 727 | nan | nan | nan | nan | CHEMBL1671764 | 20855730 | 10.1128/aac.00723-10 | 2010 | Antimicrob Agents Chemother | 54 | 5359 | 5362 | nan | nan | nan | nan | nan | nan |
CHEMBL1287471 | F | Antimicrobial activity against aac(6')-Ib-cr-positive Klebsiella pneumoniae JN41 harboring GyrA S83I, ParC S80I mutant, wild-type GyrB and qnrB genes by agar dilution method | Klebsiella pneumoniae | 10 | 10 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | JN41 | Scientific Literature | 573 | nan | nan | nan | nan | CHEMBL1275556 | 18809939 | 10.1128/aac.00830-08 | 2008 | Antimicrob Agents Chemother | 52 | 4268 | 4273 | nan | nan | nan | nan | nan | nan |
CHEMBL1674941 | F | Antifungal activity against Aspergillus fumigatus CBS 144.89 infected in immunosuppressed wild-type C57BL/6 mouse assessed as clearance of fungal forms in lung at 4.5 mg/kg administered intratracheally on days 1, 4, 7 and 11 one day post infection measured after 21 days relative to untreated control | Aspergillus fumigatus | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | CBS 144.89 | Scientific Literature | 746128 | nan | nan | nan | nan | CHEMBL1671621 | 18606837 | 10.1128/aac.00526-08 | 2008 | Antimicrob Agents Chemother | 52 | 3118 | 3126 | standard_type:DOSE standard_relation:= standard_value:4.5 standard_units:mg.kg-1 comments:None | standard_type:ROUTE standard_relation:None standard_value:None standard_units:None comments:None | nan | nan | nan | nan | nan |
CHEMBL1218178 | F | Antimicrobial activity against Klebsiella pneumoniae 2878 strain expressing beta-lactamase VIM-19 by microdilution method in presence of 4 ug/ml Tazobactam | Klebsiella pneumoniae | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | 2878 | Scientific Literature | 573 | nan | nan | nan | nan | CHEMBL1212777 | 19901092 | 10.1128/aac.00017-09 | 2010 | Antimicrob Agents Chemother | 54 | 466 | 470 | nan | nan | nan | nan | nan | nan |
CHEMBL751640 | F | Minimum bactericidal concentration against Mycobacterium tuberculosis H37Ra | Mycobacterium tuberculosis | 3 | 3 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1130732 | 9871661 | 10.1016/s0960-894x(98)00017-1 | 1998 | Bioorg Med Chem Lett | 8 | 237 | 242 | nan | nan | nan | nan | nan | nan |
CHEMBL1121093 | F | Antibacterial activity against Streptococcus pneumoniae ATCC 6305 after overnight incubation by broth microdilution method | Streptococcus pneumoniae | 5 | 5 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | ATCC 6305 | Scientific Literature | 1313 | nan | nan | nan | nan | CHEMBL1158567 | 20382539 | 10.1016/j.bmc.2010.03.045 | 2010 | Bioorg Med Chem | 18 | 3053 | 3058 | nan | nan | nan | nan | nan | nan |
CHEMBL690593 | F | Minimum inhibitory concentration against sens CL strain of Haemophilus influenzae | Haemophilus influenzae | 3 | 3 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 727 | nan | nan | nan | nan | CHEMBL1123985 | 3172134 | 10.1021/jm00118a022 | 1988 | J Med Chem | 31 | 1987 | 1993 | nan | nan | nan | nan | nan | nan |
CHEMBL619511 | F | Growth inhibitory effect of compound was measured on A-549 human lung adenocarcinoma cancer cell line | Homo sapiens | 2 | 2 | BAO_0000219 | cell-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 9606 | nan | nan | A549 | nan | CHEMBL1131717 | 10360750 | 10.1016/s0960-894x(99)00211-5 | 1999 | Bioorg Med Chem Lett | 9 | 1429 | 1432 | nan | nan | nan | nan | nan | nan |
CHEMBL824132 | F | Inhibition of anti-IgE stimulated release of leukotriene C4/D4 (LTC4/D4) from human chopped lung by 50% of control value | Homo sapiens | 6 | 6 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 9606 | nan | nan | nan | nan | CHEMBL1126285 | 1372359 | 10.1021/jm00083a023 | 1992 | J Med Chem | 35 | 958 | 965 | nan | nan | nan | nan | nan | nan |
CHEMBL723451 | F | Evaluated for median life span in mice inoculated with lewis lung carcinoma at a dose of 50 mg/kg (Experiment-1) | Mus musculus | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 10090 | nan | nan | nan | nan | CHEMBL1122352 | 6827564 | 10.1021/jm00357a024 | 1983 | J Med Chem | 26 | 445 | 448 | standard_type:DOSE standard_relation:= standard_value:50.0 standard_units:mg.kg-1 comments:None | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS | Carcinoma Oncology Models | Carcinoma Oncology Models | Carcinoma | Lewis Lung Carcinoma | nan | nan |
CHEMBL1262716 | F | Antimicrobial activity against macrolide-resistant Streptococcus pneumoniae by agar dilution method | Streptococcus pneumoniae | 6 | 18 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 1313 | nan | nan | nan | nan | CHEMBL1255353 | 18362189 | 10.1128/aac.01620-07 | 2008 | Antimicrob Agents Chemother | 52 | 2279 | 2282 | nan | nan | nan | nan | nan | nan |
CHEMBL1653213 | F | Antiviral activity against Vaccinia virus WR ATCC VR-1354 infected through intraperitoneal route in BALB/c mouse assessed as reduction of viral load in lung at 100 mg/kg, po qd measured after 5 days postinfection by RT-PCR analysis relative to control | Vaccinia virus WR | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | ATCC VR-1354 | Scientific Literature | 10254 | nan | nan | nan | nan | CHEMBL1649270 | 19752270 | 10.1128/aac.00678-09 | 2009 | Antimicrob Agents Chemother | 53 | 4999 | 5009 | standard_type:DOSE standard_relation:= standard_value:100.0 standard_units:mg.kg-1 comments:None | standard_type:ROUTE standard_relation:None standard_value:None standard_units:None comments:None | nan | nan | nan | nan | nan |
CHEMBL714767 | F | Antiviral activity was determined against Influenza virus A(strain Ishikawa) in MDCK cells by measuring concentration required to reduce virus induced cytopathogenicity by 50%. | Canis lupus familiaris | 5 | 5 | BAO_0000219 | cell-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 9615 | nan | nan | MDCK | nan | CHEMBL1128227 | 7853337 | 10.1021/jm00003a007 | 1995 | J Med Chem | 38 | 443 | 452 | nan | nan | nan | nan | nan | nan |
CHEMBL1832147 | F | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv after 28 days by agar dilution method | Mycobacterium tuberculosis | 26 | 26 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | H37Rv | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1828532 | 21723649 | 10.1016/j.ejmech.2011.06.014 | 2011 | Eur J Med Chem | 46 | 4827 | 4833 | nan | nan | nan | nan | nan | nan |
CHEMBL1114706 | B | Inhibition of Mycobacterium tuberculosis recombinant lumazine synthase at enzyme-inhibitor complex state after 30 mins by fluorescence assay | Mycobacterium tuberculosis | 6 | 6 | BAO_0000357 | single protein format | 9 | 9 - Direct single protein target assigned | nan | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1157805 | 20430628 | 10.1016/j.bmc.2010.03.072 | 2010 | Bioorg Med Chem | 18 | 3518 | 3534 | nan | nan | nan | nan | nan | nan |
CHEMBL630511 | A | Tested for biodistribution of radioactivity after 1 hr of intravenous injection in mice lung | Mus musculus | 2 | 2 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 10090 | CHEMBL3638235 | Lung | nan | nan | CHEMBL1127612 | 8057303 | 10.1021/jm00042a014 | 1994 | J Med Chem | 37 | 2609 | 2618 | nan | nan | nan | nan | nan | nan |
CHEMBL770883 | F | Compound measured for hyperpolarization of smooth muscle cells of the rabbit main pulmonary artery at concentration 0.1 uM. | Oryctolagus cuniculus | 8 | 8 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 9986 | nan | nan | nan | nan | CHEMBL1125774 | 1920358 | 10.1021/jm00114a017 | 1991 | J Med Chem | 34 | 3074 | 3085 | nan | nan | nan | nan | nan | nan |
CHEMBL1662861 | B | Displacement of Biocillin FL from Streptococcus pneumoniae 2527 PBP3 | Streptococcus pneumoniae | 5 | 5 | BAO_0000019 | assay format | 0 | 0 - Default value - Target unknown or has yet to be assigned | 2527 | Scientific Literature | 1313 | nan | nan | nan | nan | CHEMBL1649182 | 19237649 | 10.1128/aac.01566-08 | 2009 | Antimicrob Agents Chemother | 53 | 2176 | 2180 | nan | nan | nan | nan | nan | nan |
CHEMBL1799450 | F | Antimicrobial activity against Klebsiella pneumoniae CCM 2318 after 18 hrs by microdilution method | Klebsiella pneumoniae | 12 | 12 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | CCM 2318 | Scientific Literature | 573 | nan | nan | nan | nan | CHEMBL1795313 | 21543140 | 10.1016/j.ejmech.2011.04.012 | 2011 | Eur J Med Chem | 46 | 2895 | 2900 | nan | nan | nan | nan | nan | nan |
CHEMBL1226476 | B | Inhibition of penicillin-resistant Streptococcus pneumoniae 5204 PBP2x after 120 mins by SDS-PAGE | Streptococcus pneumoniae | 1 | 1 | BAO_0000357 | single protein format | 8 | 8 - Homologous single protein target assigned | 5204 | Scientific Literature | 1313 | nan | nan | nan | nan | CHEMBL1221205 | 17676039 | 10.1038/nchembio.2007.21 | 2007 | Nat Chem Biol | 3 | 565 | 569 | nan | nan | nan | nan | nan | nan |
CHEMBL1119575 | F | Antimicrobial activity against Klebsiella pneumoniae 63 after 20 hrs by broth microdilution method | Klebsiella pneumoniae | 2 | 2 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | 63 | Scientific Literature | 573 | nan | nan | nan | nan | CHEMBL1155452 | 20565063 | 10.1021/jm100378b | 2010 | J Med Chem | 53 | 5240 | 5247 | nan | nan | nan | nan | nan | nan |
CHEMBL775542 | F | The cysts/g of lung (% of control ) is calculated at a dose of 10.6 umol/kg/day against Pneumocystis carinii in rats | Rattus norvegicus | 3 | 3 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 10116 | nan | nan | nan | nan | CHEMBL1131570 | 9438029 | 10.1021/jm970570i | 1998 | J Med Chem | 41 | 124 | 129 | nan | nan | nan | nan | nan | nan |
CHEMBL1663210 | F | Antiviral activity against amantadine-sensitive Influenza A virus A/Hong Kong/8/68 (H3N2) infected in MDCK cells assessed as host cell survival after 72 hrs by CCK8 method | Influenza A virus | 15 | 15 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | A/Hong Kong/8/68 (H3N2) | Scientific Literature | 11320 | nan | nan | MDCK | nan | CHEMBL1649372 | 21094565 | 10.1016/j.ejmech.2010.10.010 | 2011 | Eur J Med Chem | 46 | 52 | 57 | nan | nan | nan | nan | nan | nan |
CHEMBL1653742 | F | Antimicrobial activity against Klebsiella pneumoniae isolate 135 expressing aac(6')-Ib-cr gene | Klebsiella pneumoniae | 8 | 8 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | isolate 135 | Scientific Literature | 573 | nan | nan | nan | nan | CHEMBL1649439 | 19289526 | 10.1128/aac.01534-08 | 2009 | Antimicrob Agents Chemother | 53 | 2643 | 2645 | nan | nan | nan | nan | nan | nan |
CHEMBL1659425 | F | Antimicrobial activity against beta-lactamase-positive ampicillin-resistant Haemophilus influenzae harboring fst1 mutant gene by broth microdilution method | Haemophilus influenzae | 1 | 3 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 727 | nan | nan | nan | nan | CHEMBL1649234 | 19651910 | 10.1128/aac.00192-09 | 2009 | Antimicrob Agents Chemother | 53 | 4225 | 4230 | nan | nan | nan | nan | nan | nan |
CHEMBL1659431 | F | Antimicrobial activity against beta-lactamase-positive ampicillin-resistant Haemophilus influenzae harboring fst1 mutant gene assessed as susceptible isolates by broth microdilution method in presence of beta-lactamase inhibitor clavulanic acid | Haemophilus influenzae | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 727 | nan | nan | nan | nan | CHEMBL1649234 | 19651910 | 10.1128/aac.00192-09 | 2009 | Antimicrob Agents Chemother | 53 | 4225 | 4230 | nan | nan | nan | nan | nan | nan |
CHEMBL751395 | F | In vitro antibacterial activity against Mycobacterium tuberculosis strain H37Rv | Mycobacterium tuberculosis | 2 | 2 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1129033 | 8576909 | 10.1021/jm9509556 | 1996 | J Med Chem | 39 | 673 | 679 | nan | nan | nan | nan | nan | nan |
CHEMBL1659976 | F | Antimicrobial activity against multidrug-resistant Klebsiella pneumoniae isolates assessed as resistance isolates by microdilution method | Klebsiella pneumoniae | 3 | 3 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 573 | nan | nan | nan | nan | CHEMBL1649286 | 19770287 | 10.1128/aac.00556-09 | 2009 | Antimicrob Agents Chemother | 53 | 4504 | 4507 | nan | nan | nan | nan | nan | nan |
CHEMBL1659981 | F | Antimicrobial activity against Penicillin-, erythromycin-resistant Streptococcus pneumoniae 37 by microdilution method | Streptococcus pneumoniae | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | 37 | Scientific Literature | 1313 | nan | nan | nan | nan | CHEMBL1649287 | 19770288 | 10.1128/aac.00785-09 | 2009 | Antimicrob Agents Chemother | 53 | 4537 | 4539 | nan | nan | nan | nan | nan | nan |
CHEMBL1280354 | F | Antibacterial activity against Staphylococcus aureus 42 in presence of 1% bovine pulmonary surfactant by CLSI method | Staphylococcus aureus | 27 | 27 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | 42 | Scientific Literature | 1280 | CHEMBL3987925 | Pulmonary surfactant | nan | nan | CHEMBL1275584 | 20086142 | 10.1128/aac.01307-09 | 2010 | Antimicrob Agents Chemother | 54 | 1404 | 1413 | nan | nan | nan | nan | nan | nan |
CHEMBL761434 | F | Bronchoalveolar lavages was collected after 6 hr in an ascaris-induced nonhuman primate model of asthma at 30 mg/kg dose (for eotaxin) | nan | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | nan | nan | nan | nan | nan | CHEMBL1133605 | 10956206 | 10.1021/jm990615a | 2000 | J Med Chem | 43 | 2975 | 2981 | standard_type:DOSE standard_relation:= standard_value:30.0 standard_units:mg.kg-1 comments:None | nan | nan | nan | nan | nan |
CHEMBL690761 | B | Percent reduction in wet lung weight relative to body weight following elastase challenge. | nan | 19 | 19 | BAO_0000221 | tissue-based format | 8 | 8 - Homologous single protein target assigned | nan | Scientific Literature | nan | CHEMBL3638235 | Lung | nan | nan | CHEMBL1128453 | 7562931 | 10.1021/jm00020a011 | 1995 | J Med Chem | 38 | 3972 | 3982 | nan | nan | nan | nan | nan | nan |
CHEMBL1695204 | F | Antibacterial activity against Klebsiella pneumoniae ATCC 10031 by broth microdilution method | Klebsiella pneumoniae | 4 | 4 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | ATCC 10031 | Scientific Literature | 573 | nan | nan | nan | nan | CHEMBL1687796 | 20805391 | 10.1128/aac.00572-10 | 2010 | Antimicrob Agents Chemother | 54 | 4636 | 4642 | nan | nan | nan | nan | nan | nan |
CHEMBL694706 | F | Minimum inhibitory concentration required for antiviral activity to reduce Cytomegalovirus (CMV) (Davis) induced cytopathicity in human embryonic lung cells (HEL) | Homo sapiens | 14 | 14 | BAO_0000219 | cell-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 9606 | nan | nan | HEL | nan | CHEMBL1127647 | 8176708 | 10.1021/jm00035a010 | 1994 | J Med Chem | 37 | 1307 | 1311 | nan | nan | nan | nan | nan | nan |
CHEMBL1695715 | F | Antimycobacterial activity against mixture of fluoroquinolone-resistant and sensitive Mycobacterium tuberculosis Beijing genotype isolates carrying heteropeaks upon sequencing at mutation site and harboring gyrA A90V and D94A mutant genes | Mycobacterium tuberculosis | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1687749 | 19721073 | 10.1128/aac.00541-09 | 2009 | Antimicrob Agents Chemother | 53 | 4835 | 4839 | nan | nan | nan | nan | nan | nan |
CHEMBL1654492 | B | Ratio of Kcat to Km for Klebsiella pneumoniae AH27 CTX-M-15 beta-lactamase | Klebsiella pneumoniae | 8 | 8 | BAO_0000357 | single protein format | 9 | 9 - Direct single protein target assigned | AH27 | Scientific Literature | 573 | nan | nan | nan | nan | CHEMBL1649220 | 19620330 | 10.1128/aac.00461-09 | 2009 | Antimicrob Agents Chemother | 53 | 4518 | 4521 | nan | nan | nan | nan | nan | nan |
CHEMBL1696095 | F | Antibacterial activity against Streptococcus pneumoniae M55B overexpressing patA, patB and inactivated patB with single mutation by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | Streptococcus pneumoniae | 2 | 2 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | M55B | Scientific Literature | 1313 | nan | nan | nan | nan | CHEMBL1687824 | 20937787 | 10.1128/aac.00672-10 | 2011 | Antimicrob Agents Chemother | 55 | 190 | 196 | nan | nan | nan | nan | nan | nan |
CHEMBL1654883 | F | Antimicrobial activity against Mycobacterium tuberculosis harboring Mycobacterium smegmatis embB gene after 48 hrs by agar proportion method | Mycobacterium tuberculosis | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1649213 | 19596878 | 10.1128/aac.00162-09 | 2009 | Antimicrob Agents Chemother | 53 | 4138 | 4146 | nan | nan | nan | nan | nan | nan |
CHEMBL688038 | F | Total cultures(10) versus active (12)at 10e-9 M conc. in hamster tracheal organ culture assay (TOC) | Cricetulus griseus | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 10029 | CHEMBL3638261 | Trachea | nan | nan | CHEMBL1122284 | 6887203 | 10.1021/jm00363a013 | 1983 | J Med Chem | 26 | 1282 | 1293 | nan | nan | nan | nan | nan | nan |
CHEMBL1694604 | F | Antibacterial activity against fluoroquinolone, dye-resistant Streptococcus pneumoniae M296 overexpressing patA, patB by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | Streptococcus pneumoniae | 2 | 2 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | M296 | Scientific Literature | 1313 | nan | nan | nan | nan | CHEMBL1687824 | 20937787 | 10.1128/aac.00672-10 | 2011 | Antimicrob Agents Chemother | 55 | 190 | 196 | nan | nan | nan | nan | nan | nan |
CHEMBL816681 | F | In vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction | Cavia porcellus | 8 | 8 | BAO_0000221 | tissue-based format | 9 | 9 - Direct single protein target assigned | nan | Scientific Literature | 10141 | CHEMBL3638235 | Lung | nan | nan | CHEMBL1134858 | 12127519 | 10.1016/s0960-894x(02)00340-2 | 2002 | Bioorg Med Chem Lett | 12 | 2125 | 2128 | nan | nan | nan | nan | nan | nan |
CHEMBL1632679 | A | Drug level in lung transplant recipient invasive aspergillosis patient plasma at 150 mg, iv QD for 4 consecutive days measured after 18 hrs post last dose by HPLC | Homo sapiens | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 9606 | CHEMBL3559721 | Plasma | nan | nan | CHEMBL1629691 | 20439610 | 10.1128/aac.01647-09 | 2010 | Antimicrob Agents Chemother | 54 | 3451 | 3459 | nan | nan | nan | nan | nan | nan |
CHEMBL1678381 | F | Antiviral activity against adamantane-resistant zanamivir-,oseltamivir-susceptible Influenza A virus (A/pdm/New York/18/2009 (H1N1)) harboring M2 V28I, S31N mutant infected in MDCK cells assessed as inhibition of viral replication after 3 days by microscopic analysis using crystal violet stain | Influenza A virus (A/New York/18/2009(H1N1)) | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 643545 | nan | nan | MDCK | nan | CHEMBL1671691 | 20350949 | 10.1128/aac.01739-09 | 2010 | Antimicrob Agents Chemother | 54 | 2517 | 2524 | nan | nan | nan | nan | nan | nan |
CHEMBL1059752 | F | Antibacterial activity against Haemophilus influenzae isolate 280 by agar dilution method | Haemophilus influenzae | 28 | 28 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | isolate 280 | Scientific Literature | 727 | nan | nan | nan | nan | CHEMBL1153012 | 19376613 | 10.1016/j.ejmech.2009.03.024 | 2009 | Eur J Med Chem | 44 | 3217 | 3227 | nan | nan | nan | nan | nan | nan |
CHEMBL1036998 | F | Antitubercular activity against Mycobacterium tuberculosis H37Rv ATCC 27294 at <0.2 ug/ml by microplate Alamar blue assay | Mycobacterium tuberculosis | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | H37Rv ATCC 27294 | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1154715 | 19926361 | 10.1016/j.ejmech.2009.10.050 | 2010 | Eur J Med Chem | 45 | 602 | 607 | nan | nan | nan | nan | nan | nan |
CHEMBL1059754 | F | Antibacterial activity against Haemophilus influenzae isolate 283 by agar dilution method | Haemophilus influenzae | 28 | 28 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | isolate 283 | Scientific Literature | 727 | nan | nan | nan | nan | CHEMBL1153012 | 19376613 | 10.1016/j.ejmech.2009.03.024 | 2009 | Eur J Med Chem | 44 | 3217 | 3227 | nan | nan | nan | nan | nan | nan |
CHEMBL1072402 | F | Bronchoprotection in guinea pig Konzett-Roessler model assessed as inhibition of acetylcholine-induced increase in pulmonary resistance at 1 ug/kg, intratracheal administered after 3 acetylcholine challenges every 10 mins measured after 120 mins | Cavia porcellus | 4 | 4 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 10141 | nan | nan | nan | nan | CHEMBL1156887 | 20096576 | 10.1016/j.bmcl.2009.12.087 | 2010 | Bioorg Med Chem Lett | 20 | 1410 | 1414 | nan | RESPIRATORY SYSTEM | RESPIRATORY SYSTEM | Effects on Air Ways | Effects on Air Ways | Bronchospasmolytic Activity in Anesthetized Guinea Pigs (Konzett Rossler method) | General Airway Models | nan | nan |
CHEMBL1266470 | F | Antimicrobial activity against Klebsiella pneumoniae KP63 after 18 hrs by rapid INT colorimetric assay | Klebsiella pneumoniae | 5 | 5 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | KP63 | Scientific Literature | 573 | nan | nan | nan | nan | CHEMBL1255429 | 20160051 | 10.1128/aac.01533-09 | 2010 | Antimicrob Agents Chemother | 54 | 1749 | 1752 | nan | nan | nan | nan | nan | nan |
CHEMBL1066857 | F | Bronchoprotection in guinea pig Konzett-Roessler model assessed as inhibition of acetylcholine-induced increase in pulmonary resistance at 0.3 ug/kg, intratracheal administered after 3 acetylcholine challenges every 10 mins measured after 270 mins | Cavia porcellus | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 10141 | nan | nan | nan | nan | CHEMBL1156887 | 20096576 | 10.1016/j.bmcl.2009.12.087 | 2010 | Bioorg Med Chem Lett | 20 | 1410 | 1414 | nan | RESPIRATORY SYSTEM | RESPIRATORY SYSTEM | Effects on Air Ways | Effects on Air Ways | Bronchospasmolytic Activity in Anesthetized Guinea Pigs (Konzett Rossler method) | General Airway Models | nan | nan |
CHEMBL1266853 | F | Antimicrobial activity against Klebsiella pneumoniae isolate Kp6A expressing beta-lactamase OXA-48 and TEM-150 by Etest method | Klebsiella pneumoniae | 12 | 12 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | isolate Kp6A | Scientific Literature | 573 | nan | nan | nan | nan | CHEMBL1255404 | 20086157 | 10.1128/aac.01312-09 | 2010 | Antimicrob Agents Chemother | 54 | 1369 | 1373 | nan | nan | nan | nan | nan | nan |
CHEMBL1110675 | A | Biodistribution in human lung at 108.7 mg, iv after 3 hrs | Homo sapiens | 1 | 1 | BAO_0000218 | organism-based format | 0 | 0 - Default value - Target unknown or has yet to be assigned | nan | Scientific Literature | 9606 | CHEMBL3638235 | Lung | nan | nan | CHEMBL1156308 | 20205479 | 10.1021/jm901858n | 2010 | J Med Chem | 53 | 2882 | 2891 | nan | nan | nan | nan | nan | nan |
CHEMBL1662019 | F | Antimicrobial activity against Mycobacterium tuberculosis harboring 263V to I mutation in thymidylate synthase A by agar dilution method | Mycobacterium tuberculosis | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1649181 | 19237648 | 10.1128/aac.01197-08 | 2009 | Antimicrob Agents Chemother | 53 | 2100 | 2109 | nan | nan | nan | nan | nan | nan |
CHEMBL1681426 | F | Bactericidal activity against penicillin-sensitive Streptococcus pneumoniae ATCC 6303 at 8 times MIC after 24 hrs by time kill analysis | Streptococcus pneumoniae | 2 | 2 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | ATCC 6303 | Scientific Literature | 1313 | nan | nan | nan | nan | CHEMBL1671635 | 18779351 | 10.1128/aac.00427-08 | 2008 | Antimicrob Agents Chemother | 52 | 3994 | 4000 | nan | nan | nan | nan | nan | nan |
CHEMBL1681432 | F | Antimicrobial activity against penicillin-sensitive Streptococcus pneumoniae ATCC 6303 assessed as maximum killing rate constant | Streptococcus pneumoniae | 2 | 2 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | ATCC 6303 | Scientific Literature | 1313 | nan | nan | nan | nan | CHEMBL1671635 | 18779351 | 10.1128/aac.00427-08 | 2008 | Antimicrob Agents Chemother | 52 | 3994 | 4000 | nan | nan | nan | nan | nan | nan |
CHEMBL807298 | F | Antibacterial activity against Staphylococcus pneumoniae G9a was determined | Staphylococcus | 2 | 2 | BAO_0000019 | assay format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 1279 | nan | nan | nan | nan | CHEMBL1136146 | 12873484 | 10.1016/s0960-894x(03)00578-x | 2003 | Bioorg Med Chem Lett | 13 | 2641 | 2645 | nan | nan | nan | nan | nan | nan |
CHEMBL1677816 | F | Antiviral activity against oseltamivir-susceptible zanamivir-, adamantane-resistant Influenza A virus (A/Bethesda/956/2006(H3N2)) harboring neuraminidase R292K mutant and M2 S31N mutant infected in MDCK cells assessed as inhibition of viral replication after 3 days by microscopic analysis using crystal violet stain | Influenza A virus (A/Bethesda/956/2006(H3N2)) | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 742689 | nan | nan | MDCK | nan | CHEMBL1671691 | 20350949 | 10.1128/aac.01739-09 | 2010 | Antimicrob Agents Chemother | 54 | 2517 | 2524 | nan | nan | nan | nan | nan | nan |
CHEMBL1676078 | F | Antiviral activity against adamantane-resistant zanamivir-,oseltamivir-susceptible Influenza A virus (A/pdm/Mexico/4604/2009(H1N1)) harboring M2 V28I, S31N mutant infected in MDCK cells assessed as determination of viral titer in cell culture at 128 uM after 24 hrs by immunofluorescence assay | Influenza A virus (A/Mexico/4604/2009(H1N1)) | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 644888 | nan | nan | MDCK | nan | CHEMBL1671691 | 20350949 | 10.1128/aac.01739-09 | 2010 | Antimicrob Agents Chemother | 54 | 2517 | 2524 | nan | nan | nan | nan | nan | nan |
CHEMBL1676812 | F | Antiviral activity against Influenza A virus (A/Mexico/4604/2009(H1N1)) infected in MDCK cells from Mill Hill assessed as log reduction in viral titer at 128 uM after 24 hrs by immunofluorescent assay | Influenza A virus (A/Mexico/4604/2009(H1N1)) | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 644888 | nan | nan | MDCK | nan | CHEMBL1671691 | 20350949 | 10.1128/aac.01739-09 | 2010 | Antimicrob Agents Chemother | 54 | 2517 | 2524 | nan | nan | nan | nan | nan | nan |
CHEMBL657030 | B | Inhibitory activity against Carbonic anhydrase IV isolated from bovine lung | Bos taurus | 34 | 34 | BAO_0000357 | single protein format | 9 | 9 - Direct single protein target assigned | nan | Scientific Literature | 9913 | nan | nan | nan | nan | CHEMBL1136178 | 14611846 | 10.1016/s0960-894x(03)00580-8 | 2003 | Bioorg Med Chem Lett | 13 | 2867 | 2873 | nan | nan | nan | nan | nan | nan |
CHEMBL1177193 | B | Inhibition of N-terminal His-tagged Mycobacterium tuberculosis H37Rv IMPDH | Mycobacterium tuberculosis H37Rv | 12 | 12 | BAO_0000019 | assay format | 0 | 0 - Default value - Target unknown or has yet to be assigned | nan | Scientific Literature | 83332 | nan | nan | nan | nan | CHEMBL1177707 | 20491506 | 10.1021/jm100424m | 2010 | J Med Chem | 53 | 4768 | 4778 | nan | nan | nan | nan | nan | nan |
CHEMBL1251129 | F | Antibacterial activity against Klebsiella pneumoniae at 25 ug/ml after 18 hrs by cup plate method | Klebsiella pneumoniae | 4 | 4 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 573 | nan | nan | nan | nan | CHEMBL1250501 | 20705368 | 10.1016/j.ejmech.2010.07.015 | 2010 | Eur J Med Chem | 45 | 4545 | 4553 | nan | nan | nan | nan | nan | nan |
CHEMBL1787703 | F | Antibacterial activity against Klebsiella pneumoniae at 15 ug after 24 hrs by disc diffusion assay | Klebsiella pneumoniae | 9 | 9 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 573 | nan | nan | nan | nan | CHEMBL1781873 | 21444131 | 10.1016/j.ejmech.2011.02.060 | 2011 | Eur J Med Chem | 46 | 2075 | 2082 | nan | nan | nan | nan | nan | nan |
CHEMBL703681 | F | In vitro minimum inhibitory concentration against Klebsiella pneumoniae B54 | Klebsiella pneumoniae | 10 | 10 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 573 | nan | nan | nan | nan | CHEMBL1126791 | 8410974 | 10.1021/jm00070a005 | 1993 | J Med Chem | 36 | 2621 | 2626 | nan | nan | nan | nan | nan | nan |
CHEMBL1662822 | B | Displacement of Biocillin FL from Streptococcus pneumoniae 1077 PBP1A | Streptococcus pneumoniae | 5 | 5 | BAO_0000357 | single protein format | 8 | 8 - Homologous single protein target assigned | 1077 | Scientific Literature | 1313 | nan | nan | nan | nan | CHEMBL1649182 | 19237649 | 10.1128/aac.01566-08 | 2009 | Antimicrob Agents Chemother | 53 | 2176 | 2180 | nan | nan | nan | nan | nan | nan |
CHEMBL1662833 | B | Displacement of Biocillin FL from Streptococcus pneumoniae 3413 PBP2X | Streptococcus pneumoniae | 5 | 5 | BAO_0000357 | single protein format | 8 | 8 - Homologous single protein target assigned | 3413 | Scientific Literature | 1313 | nan | nan | nan | nan | CHEMBL1649182 | 19237649 | 10.1128/aac.01566-08 | 2009 | Antimicrob Agents Chemother | 53 | 2176 | 2180 | nan | nan | nan | nan | nan | nan |
CHEMBL1693426 | F | Antimicrobial activity against Pseudomonas aeruginosa isolate 12 obtained from cystic fibrosis patients after 16 to 20 hrs by broth microdilution method | Pseudomonas aeruginosa | 3 | 3 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | isolate 12 | Scientific Literature | 287 | nan | nan | nan | nan | CHEMBL1687785 | 20713660 | 10.1128/aac.00009-10 | 2010 | Antimicrob Agents Chemother | 54 | 4772 | 4779 | nan | nan | nan | nan | nan | nan |
CHEMBL715591 | F | compound was tested for antiviral activity against Herpes Simplex virus Type-2(17409) in human lung fibroblasts (MRC-5) | Homo sapiens | 1 | 1 | BAO_0000219 | cell-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 9606 | nan | nan | MRC5 | nan | CHEMBL1123836 | 3040998 | 10.1021/jm00392a020 | 1987 | J Med Chem | 30 | 1636 | 1642 | nan | nan | nan | nan | nan | nan |
CHEMBL690188 | F | In vitro minimum inhibitory concentration against Haemophilus influenzae DILL using standard agar dilution method | Haemophilus influenzae | 23 | 23 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 727 | nan | nan | nan | nan | CHEMBL1133079 | 10782693 | 10.1016/s0960-894x(00)00106-2 | 2000 | Bioorg Med Chem Lett | 10 | 815 | 819 | nan | nan | nan | nan | nan | nan |
CHEMBL1114806 | B | Inhibition of Influenza A PR/8/34 H1N1 virus neuraminidase activity by MUN-ANA substrate based fluorimetric assay | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | 27 | 52 | BAO_0000357 | single protein format | 9 | 9 - Direct single protein target assigned | nan | Scientific Literature | 211044 | nan | nan | nan | nan | CHEMBL1157844 | 20116898 | 10.1016/j.ejmech.2010.01.005 | 2010 | Eur J Med Chem | 45 | 1724 | 1730 | nan | nan | nan | nan | nan | nan |
CHEMBL1262036 | F | Antimicrobial activity against Streptococcus pneumoniae PU1071099 harboring 65WR66 deletion in ribosomal protein L4 by broth microdilution method | Streptococcus pneumoniae | 5 | 5 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | PU1071099 | Scientific Literature | 1313 | nan | nan | nan | nan | CHEMBL1255340 | 18316525 | 10.1128/aac.01383-07 | 2008 | Antimicrob Agents Chemother | 52 | 1653 | 1662 | nan | nan | nan | nan | nan | nan |
CHEMBL752239 | F | Flow cytometry proliferation assay in human lung NCI-460 cell line (Not tested) | Homo sapiens | 8 | 8 | BAO_0000219 | cell-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 9606 | nan | nan | NCI-H460 | nan | CHEMBL1136337 | 14552792 | 10.1016/s0960-894x(03)00792-3 | 2003 | Bioorg Med Chem Lett | 13 | 3841 | 3846 | nan | nan | nan | nan | nan | nan |
CHEMBL1666748 | F | Antibacterial activity against Klebsiella pneumoniae isolate 2-54 by broth dilution method | Klebsiella pneumoniae | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | isolate 2-54 | Scientific Literature | 573 | nan | nan | nan | nan | CHEMBL1649569 | 19528276 | 10.1128/aac.01574-08 | 2009 | Antimicrob Agents Chemother | 53 | 3582 | 3584 | nan | nan | nan | nan | nan | nan |
CHEMBL627215 | A | 200 mg/kg of [14C]- radiolabeled compound was orally (gavage) injected in rabbit 2 lung, and radioactivity content in feces was estimated | Oryctolagus cuniculus | 1 | 2 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 9986 | CHEMBL3638230 | Feces | nan | nan | CHEMBL1121475 | 7401104 | 10.1021/jm00181a014 | 1980 | J Med Chem | 23 | 773 | 780 | nan | nan | nan | nan | nan | nan |
CHEMBL1963889 | F | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the LXFL 529 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | nan | 13980 | 14071 | BAO_0000219 | cell-based format | 1 | 1 - Target assigned is non-molecular | nan | PubChem BioAssays | nan | nan | nan | LXFL 529 | nan | CHEMBL1201862 | nan | nan | nan | nan | nan | nan | nan | nan | nan | nan | nan | nan | nan |
CHEMBL1218328 | F | Ratio of fCmax to MIC90 for penicillin-intermediate Streptococcus pneumoniae | Streptococcus pneumoniae | 1 | 1 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 1313 | nan | nan | nan | nan | CHEMBL1212766 | 19884368 | 10.1128/aac.00682-09 | 2010 | Antimicrob Agents Chemother | 54 | 405 | 410 | nan | nan | nan | nan | nan | nan |
CHEMBL1821391 | B | Inhibition of Haemophilus influenzae DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate addition by spectrophotometry | Haemophilus influenzae | 26 | 26 | BAO_0000019 | assay format | 0 | 0 - Default value - Target unknown or has yet to be assigned | nan | Scientific Literature | 727 | nan | nan | nan | nan | CHEMBL1817628 | 21831637 | 10.1016/j.bmcl.2011.07.059 | 2011 | Bioorg Med Chem Lett | 21 | 5171 | 5176 | nan | nan | nan | nan | nan | nan |
CHEMBL805638 | F | In Vitro antibacterial activity against Streptococcus pneumoniae ATCC 6303 (Ery-S strain) | Streptococcus pneumoniae | 10 | 10 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 1313 | nan | nan | nan | nan | CHEMBL1145026 | 12723941 | 10.1021/jm025580k | 2003 | J Med Chem | 46 | 1795 | 1798 | nan | nan | nan | nan | nan | nan |
CHEMBL1954023 | F | Antitubercular activity against multidrug-resistant isoniazid, rifampicin, ethambutol, pyrazinamide, streptomycin, p-aminosalicylic acid-resistant Mycobacterium tuberculosis clinical isolate by microbroth dilution assay | Mycobacterium tuberculosis | 3 | 3 | BAO_0000218 | organism-based format | 1 | 1 - Target assigned is non-molecular | nan | Scientific Literature | 1773 | nan | nan | nan | nan | CHEMBL1949614 | 21691438 | 10.1021/ml200036r | 2011 | ACS Med Chem Lett | 2 | 466 | 470 | nan | nan | nan | nan | nan | nan |
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