unprocessed
stringlengths 304
1.61k
| processed
stringlengths 4
1.52k
|
|---|---|
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The rate of resolution of the radiographic findings may be helpful in distinguishing between true pyeloureteritis cystica and submucosal hemorrhage .
### Output Text: | The rate of resolution of the radiographic findings may be helpful in distinguishing between true pyeloureteritis cystica and submucosal hemorrhage . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Nephrotoxic effects in high - risk patients undergoing angiography .
### Output Text: | Nephrotoxic effects in high - risk patients undergoing angiography . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: BACKGROUND : The use of iodinated contrast medium can result in nephropathy .
### Output Text: | BACKGROUND : The use of iodinated contrast medium can result in nephropathy . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Whether iso - osmolar contrast medium is less nephrotoxic than low - osmolar contrast medium in high - risk patients is uncertain .
### Output Text: | Whether iso - osmolar contrast medium is less nephrotoxic than low - osmolar contrast medium in high - risk patients is uncertain . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: METHODS : We conducted a randomized , double - blind , prospective , multicenter study comparing the nephrotoxic effects of an iso - osmolar , dimeric , nonionic contrast medium , iodixanol , with those of a low - osmolar , nonionic , monomeric contrast medium , iohexol .
### Output Text: | METHODS : We conducted a randomized , double - blind , prospective , multicenter study comparing the nephrotoxic effects of an iso - osmolar , dimeric , nonionic contrast medium , <span class="chemical">iodixanol</span> , with those of a low - osmolar , nonionic , monomeric contrast medium , <span class="chemical">iohexol</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The study involved 129 patients with diabetes with serum creatinine concentrations of 1 . 5 to 3 . 5 mg per deciliter who underwent coronary or aortofemoral angiography .
### Output Text: | The study involved 129 patients with diabetes with serum <span class="chemical">creatinine</span> concentrations of 1 . 5 to 3 . 5 mg per deciliter who underwent coronary or aortofemoral angiography . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The primary end point was the peak increase from base line in the creatinine concentration during the three days after angiography .
### Output Text: | The primary end point was the peak increase from base line in the <span class="chemical">creatinine</span> concentration during the three days after angiography . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Other end points were an increase in the creatinine concentration of 0 . 5 mg per deciliter or more , an increase of 1 . 0 mg per deciliter or more , and a change in the creatinine concentration from day 0 to day 7 .
### Output Text: | Other end points were an increase in the <span class="chemical">creatinine</span> concentration of 0 . 5 mg per deciliter or more , an increase of 1 . 0 mg per deciliter or more , and a change in the <span class="chemical">creatinine</span> concentration from day 0 to day 7 . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: RESULTS : The creatinine concentration increased significantly less in patients who received iodixanol .
### Output Text: | RESULTS : The <span class="chemical">creatinine</span> concentration increased significantly less in patients who received <span class="chemical">iodixanol</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: From day 0 to day 3 , the mean peak increase in creatinine was 0 . 13 mg per deciliter in the iodixanol group and 0 . 55 mg per deciliter in the iohexol group ( P = 0 . 001 ; the increase with iodixanol minus the increase with iohexol , - 0 . 42 mg per deciliter [ 95 percent confidence interval , - 0 . 73 to - 0 . 22 ] ) .
### Output Text: | From day 0 to day 3 , the mean peak increase in <span class="chemical">creatinine</span> was 0 . 13 mg per deciliter in the <span class="chemical">iodixanol</span> group and 0 . 55 mg per deciliter in the <span class="chemical">iohexol</span> group ( P = 0 . 001 ; the increase with <span class="chemical">iodixanol</span> minus the increase with <span class="chemical">iohexol</span> , - 0 . 42 mg per deciliter [ 95 percent confidence interval , - 0 . 73 to - 0 . 22 ] ) . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Two of the 64 patients in the iodixanol group ( 3 percent ) had an increase in the creatinine concentration of 0 . 5 mg per deciliter or more , as compared with 17 of the 65 patients in the iohexol group ( 26 percent ) ( P = 0 . 002 ; odds ratio for such an increase in the iodixanol group , 0 . 09 [ 95 percent confidence interval , 0 . 02 to 0 . 41 ] ) .
### Output Text: | Two of the 64 patients in the <span class="chemical">iodixanol</span> group ( 3 percent ) had an increase in the <span class="chemical">creatinine</span> concentration of 0 . 5 mg per deciliter or more , as compared with 17 of the 65 patients in the <span class="chemical">iohexol</span> group ( 26 percent ) ( P = 0 . 002 ; odds ratio for such an increase in the <span class="chemical">iodixanol</span> group , 0 . 09 [ 95 percent confidence interval , 0 . 02 to 0 . 41 ] ) . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: No patient receiving iodixanol had an increase of 1 . 0 mg per deciliter or more , but 10 patients in the iohexol group ( 15 percent ) did .
### Output Text: | No patient receiving <span class="chemical">iodixanol</span> had an increase of 1 . 0 mg per deciliter or more , but 10 patients in the <span class="chemical">iohexol</span> group ( 15 percent ) did . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The mean change in the creatinine concentration from day 0 to day 7 was 0 . 07 mg per deciliter in the iodixanol group and 0 . 24 mg per deciliter in the iohexol group ( P = 0 . 003 ; value in the iodixanol group minus the value in the iohexol group , - 0 . 17 mg per deciliter [ 95 percent confidence interval , - 0 . 34 to - 0 . 07 ] ) .
### Output Text: | The mean change in the <span class="chemical">creatinine</span> concentration from day 0 to day 7 was 0 . 07 mg per deciliter in the <span class="chemical">iodixanol</span> group and 0 . 24 mg per deciliter in the <span class="chemical">iohexol</span> group ( P = 0 . 003 ; value in the <span class="chemical">iodixanol</span> group minus the value in the <span class="chemical">iohexol</span> group , - 0 . 17 mg per deciliter [ 95 percent confidence interval , - 0 . 34 to - 0 . 07 ] ) . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: CONCLUSIONS : Nephropathy induced by contrast medium may be less likely to develop in high - risk patients when iodixanol is used rather than a low - osmolar , nonionic contrast medium .
### Output Text: | CONCLUSIONS : Nephropathy induced by contrast medium may be less likely to develop in high - risk patients when <span class="chemical">iodixanol</span> is used rather than a low - osmolar , nonionic contrast medium . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Protective effect of edaravone against streptomycin - induced vestibulotoxicity in the guinea pig .
### Output Text: | Protective effect of <span class="chemical">edaravone</span> against <span class="chemical">streptomycin</span> - induced vestibulotoxicity in the guinea pig . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: This study investigated alleviation of streptomycin - induced vestibulotoxicity by edaravone in guinea pigs .
### Output Text: | This study investigated alleviation of <span class="chemical">streptomycin</span> - induced vestibulotoxicity by <span class="chemical">edaravone</span> in guinea pigs . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Edaravone , a free radical scavenger , has potent free radical quenching action and is used in clinical practice to treat cerebral infarction .
### Output Text: | <span class="chemical">Edaravone</span> , a free radical scavenger , has potent free radical quenching action and is used in clinical practice to treat cerebral infarction . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Streptomycin was administered to the inner ear by osmotic pump for 24 h , and edaravone ( n = 8 ) or saline ( n = 6 ) was intraperitoneally injected once a day for 7 days .
### Output Text: | <span class="chemical">Streptomycin</span> was administered to the inner ear by osmotic pump for 24 h , and <span class="chemical">edaravone</span> ( n = 8 ) or saline ( n = 6 ) was intraperitoneally injected once a day for 7 days . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: We observed horizontal vestibulo - ocular reflex as a marker of postoperative vestibular function .
### Output Text: | We observed horizontal vestibulo - ocular reflex as a marker of postoperative vestibular function . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Animals injected with saline showed statistically smaller gains than those injected with edaravone .
### Output Text: | Animals injected with saline showed statistically smaller gains than those injected with <span class="chemical">edaravone</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: These results suggest that edaravone suppresses streptomycin - induced vestibulotoxicity .
### Output Text: | These results suggest that <span class="chemical">edaravone</span> suppresses <span class="chemical">streptomycin</span> - induced vestibulotoxicity . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Levodopa - induced oromandibular dystonia in progressive supranuclear palsy .
### Output Text: | <span class="chemical">Levodopa</span> - induced oromandibular dystonia in progressive supranuclear palsy . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Levodopa - induced dyskinesias have been reported in Parkinson ' s disease and multiple system atrophy .
### Output Text: | <span class="chemical">Levodopa</span> - induced dyskinesias have been reported in Parkinson ' s disease and multiple system atrophy . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Cranial dystonias are rare in patients with progressive supranuclear palsy ( PSP ) .
### Output Text: | Cranial dystonias are rare in patients with progressive supranuclear palsy ( PSP ) . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: In this report we describe an unusual case of reversible levodopa - induced Oromandibular dystonia ( OMD ) in a PSP patient to highlight the importance of recognizing this drug related complication in the management of PSP , and discuss the possible underlying pathophysiology .
### Output Text: | In this report we describe an unusual case of reversible <span class="chemical">levodopa</span> - induced Oromandibular dystonia ( OMD ) in a PSP patient to highlight the importance of recognizing this drug related complication in the management of PSP , and discuss the possible underlying pathophysiology . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Case report : Dexatrim ( Phenylpropanolamine ) as a cause of myocardial infarction .
### Output Text: | Case report : <span class="chemical">Dexatrim</span> ( <span class="chemical">Phenylpropanolamine</span> ) as a cause of myocardial infarction . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Phenylpropanolamine ( PPA ) is a sympathetic amine used in over - the - counter cold remedies and weight - control preparations worldwide .
### Output Text: | <span class="chemical">Phenylpropanolamine</span> ( <span class="chemical">PPA</span> ) is a sympathetic <span class="chemical">amine</span> used in over - the - counter cold remedies and weight - control preparations worldwide . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Its use has been associated with hypertensive episodes and hemorrhagic strokes in younger women .
### Output Text: | Its use has been associated with hypertensive episodes and hemorrhagic strokes in younger women . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Several reports have linked the abuse of PPA with myocardial injury , especially when overdose is involved .
### Output Text: | Several reports have linked the abuse of <span class="chemical">PPA</span> with myocardial injury , especially when overdose is involved . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: We report here the first case of Dexatrim ( PPA ) - induced myocardial injury in a young woman who was using it at recommended doses for weight control .
### Output Text: | We report here the first case of <span class="chemical">Dexatrim</span> ( <span class="chemical">PPA</span> ) - induced myocardial injury in a young woman who was using it at recommended doses for weight control . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: In addition , we review the 7 other cases of PPA related myocardial injury that have been reported so far .
### Output Text: | In addition , we review the 7 other cases of <span class="chemical">PPA</span> related myocardial injury that have been reported so far . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Physicians and patients should be alert to the potential cardiac risk associated with the use of PPA , even at doses generally considered to be safe .
### Output Text: | Physicians and patients should be alert to the potential cardiac risk associated with the use of <span class="chemical">PPA</span> , even at doses generally considered to be safe . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Differential diagnosis of high serum creatine kinase levels in systemic lupus erythematosus .
### Output Text: | Differential diagnosis of high serum <span class="chemical">creatine</span> kinase levels in systemic lupus erythematosus . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: We report the clinical and bioptic findings for a 57 - year - old woman with severe chloroquine - induced myopathy .
### Output Text: | We report the clinical and bioptic findings for a 57 - year - old woman with severe <span class="chemical">chloroquine</span> - induced myopathy . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Since 1989 , she had been suffering from systemic lupus erythematosus ( SLE ) with renal involvement and undergone periods of treatment with azathioprine and cyclophosphamide .
### Output Text: | Since 1989 , she had been suffering from systemic lupus erythematosus ( SLE ) with renal involvement and undergone periods of treatment with <span class="chemical">azathioprine</span> and <span class="chemical">cyclophosphamide</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Additional therapy with chloroquine ( CQ ) was started because of arthralgia .
### Output Text: | Additional therapy with <span class="chemical">chloroquine</span> ( <span class="chemical">CQ</span> ) was started because of arthralgia . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: At the same time , slightly increased creatine kinase ( CK ) levels were noted .
### Output Text: | At the same time , slightly increased <span class="chemical">creatine</span> kinase ( CK ) levels were noted . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Myositis was suspected , and the patient was treated with steroids .
### Output Text: | Myositis was suspected , and the patient was treated with <span class="chemical">steroids</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The CK increase persisted , however , and she developed progressive muscular weakness and muscular atrophy .
### Output Text: | The CK increase persisted , however , and she developed progressive muscular weakness and muscular atrophy . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Routine controls revealed markedly elevated CK levels of 1 , 700 U / l .
### Output Text: | Routine controls revealed markedly elevated CK levels of 1 , 700 U / l . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The neurological and electrophysiological findings were not typical of myositis .
### Output Text: | The neurological and electrophysiological findings were not typical of myositis . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Thus , muscle biopsy of the deltoid muscle was performed in order to exclude polymyositis or toxic myopathy .
### Output Text: | Thus , muscle biopsy of the deltoid muscle was performed in order to exclude polymyositis or toxic myopathy . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: As it revealed chloroquine - induced myopathy , medication was stopped .
### Output Text: | As it revealed <span class="chemical">chloroquine</span> - induced myopathy , medication was stopped . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Discriminating between primary SLE - induced affection of the musculoskeletal system and drug - induced side effects is important for appropriate treatment of SLE patients .
### Output Text: | Discriminating between primary SLE - induced affection of the musculoskeletal system and drug - induced side effects is important for appropriate treatment of SLE patients . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Seizure associated with sleep deprivation and sustained - release bupropion .
### Output Text: | Seizure associated with sleep deprivation and sustained - release <span class="chemical">bupropion</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: This case report describes a generalized seizure associated with sustained - release bupropion use and sleep deprivation .
### Output Text: | This case report describes a generalized seizure associated with sustained - release <span class="chemical">bupropion</span> use and sleep deprivation . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The subject , a 31 - year - old female smoker , was participating in a clinical trial evaluating an investigational medication for smoking cessation that used sustained - release bupropion as an active control .
### Output Text: | The subject , a 31 - year - old female smoker , was participating in a clinical trial evaluating an investigational medication for smoking cessation that used sustained - release <span class="chemical">bupropion</span> as an active control . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: After 5 weeks of bupropion use , the subject experienced a generalized tonic clonic seizure after staying up nearly all night packing and moving to a new residence .
### Output Text: | After 5 weeks of <span class="chemical">bupropion</span> use , the subject experienced a generalized tonic clonic seizure after staying up nearly all night packing and moving to a new residence . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The patient had no other risk factors for seizures .
### Output Text: | The patient had no other risk factors for seizures . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: We suggest that sleep deprivation may add to the risk of bupropion - associated seizures .
### Output Text: | We suggest that sleep deprivation may add to the risk of <span class="chemical">bupropion</span> - associated seizures . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Postoperative myalgia after succinylcholine : no evidence for an inflammatory origin .
### Output Text: | Postoperative myalgia after <span class="chemical">succinylcholine</span> : no evidence for an inflammatory origin . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: A common side effect associated with succinylcholine is postoperative myalgia .
### Output Text: | A common side effect associated with <span class="chemical">succinylcholine</span> is postoperative myalgia . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The pathogenesis of this myalgia is still unclear ; inflammation has been suggested but without convincing evidence .
### Output Text: | The pathogenesis of this myalgia is still unclear ; inflammation has been suggested but without convincing evidence . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: We designed the present study to investigate whether an inflammatory reaction contributes to this myalgia .
### Output Text: | We designed the present study to investigate whether an inflammatory reaction contributes to this myalgia . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The incidence and severity of succinylcholine - associated myalgia was determined in 64 patients pretreated with saline or dexamethasone before succinylcholine ( n = 32 for each ) .
### Output Text: | The incidence and severity of <span class="chemical">succinylcholine</span> - associated myalgia was determined in 64 patients pretreated with saline or <span class="chemical">dexamethasone</span> before <span class="chemical">succinylcholine</span> ( n = 32 for each ) . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Incidence and severity of myalgia did not differ significantly between the two groups : 15 patients in the dexamethasone group complained of myalgia compared with 18 patients in the saline group , and severe myalgia was reported by five patients and three patients , respectively ( not significant ) .
### Output Text: | Incidence and severity of myalgia did not differ significantly between the two groups : 15 patients in the <span class="chemical">dexamethasone</span> group complained of myalgia compared with 18 patients in the saline group , and severe myalgia was reported by five patients and three patients , respectively ( not significant ) . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: At 48 h after surgery , 12 patients in both groups still suffered from myalgia ( not significant ) .
### Output Text: | At 48 h after surgery , 12 patients in both groups still suffered from myalgia ( not significant ) . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: In addition , interleukin - 6 ( IL - 6 ) as an early marker of inflammation was assessed in a subgroup of 10 patients pretreated with saline .
### Output Text: | In addition , interleukin - 6 ( IL - 6 ) as an early marker of inflammation was assessed in a subgroup of 10 patients pretreated with saline . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: We found an increase of IL - 6 for only three patients , but only one patient reported myalgia ; no relationship between myalgia and the increase of IL - 6 was found .
### Output Text: | We found an increase of IL - 6 for only three patients , but only one patient reported myalgia ; no relationship between myalgia and the increase of IL - 6 was found . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: In conclusion , there is no evidence for an inflammatory origin of succinylcholine - associated myalgia .
### Output Text: | In conclusion , there is no evidence for an inflammatory origin of <span class="chemical">succinylcholine</span> - associated myalgia . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: IMPLICATIONS : Administration of dexamethasone before succinylcholine was not effective in decreasing the incidence or the severity of succinylcholine - induced postoperative myalgia .
### Output Text: | IMPLICATIONS : Administration of <span class="chemical">dexamethasone</span> before <span class="chemical">succinylcholine</span> was not effective in decreasing the incidence or the severity of <span class="chemical">succinylcholine</span> - induced postoperative myalgia . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Furthermore , there was no significant relationship between postoperative myalgia and time course of interleukin - 6 concentrations , a marker of inflammation .
### Output Text: | Furthermore , there was no significant relationship between postoperative myalgia and time course of interleukin - 6 concentrations , a marker of inflammation . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Pretreatment with dexamethasone is not justified to prevent postoperative myalgia after succinylcholine .
### Output Text: | Pretreatment with <span class="chemical">dexamethasone</span> is not justified to prevent postoperative myalgia after <span class="chemical">succinylcholine</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Effect of lindane on hepatic and brain cytochrome P450s and influence of P450 modulation in lindane induced neurotoxicity .
### Output Text: | Effect of <span class="chemical">lindane</span> on hepatic and brain cytochrome P450s and influence of P450 modulation in <span class="chemical">lindane</span> induced neurotoxicity . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Oral administration of lindane ( 2 . 5 , 5 , 10 and 15 mg / kg , body weight ) for 5 days was found to produce a dose - dependent increase in the activity of P450 dependent 7 - ethoxyresorufin - O - deethylase ( EROD ) , 7 - pentoxyresorufin - O - dealkylase ( PROD ) and N - nitrosodimethylamine demethylase ( NDMA - d ) in rat brain and liver .
### Output Text: | Oral administration of <span class="chemical">lindane</span> ( 2 . 5 , 5 , 10 and 15 mg / kg , body weight ) for 5 days was found to produce a dose - dependent increase in the activity of P450 dependent 7 - ethoxyresorufin - O - deethylase ( EROD ) , 7 - pentoxyresorufin - O - dealkylase ( PROD ) and <span class="chemical">N - nitrosodimethylamine</span> demethylase ( <span class="chemical">NDMA</span> - d ) in rat brain and liver . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: A significant increase in the hepatic and brain P450 monooxygenases was also observed when the duration of exposure of low dose ( 2 . 5 mg / kg ) of lindane was increased from 5 days to 15 or 21 days .
### Output Text: | A significant increase in the hepatic and brain P450 monooxygenases was also observed when the duration of exposure of low dose ( 2 . 5 mg / kg ) of <span class="chemical">lindane</span> was increased from 5 days to 15 or 21 days . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: As observed with different doses , the magnitude of induction in the activity of P450 monooxygenases was several fold higher in liver microsomes when compared with the brain .
### Output Text: | As observed with different doses , the magnitude of induction in the activity of P450 monooxygenases was several fold higher in liver microsomes when compared with the brain . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Western blotting studies have indicated that the increase in the P450 enzymes could be due to the increase in the expression of P450 1A1 / 1A2 , 2B1 / 2B2 and 2E1 isoenzymes .
### Output Text: | Western blotting studies have indicated that the increase in the P450 enzymes could be due to the increase in the expression of P450 1A1 / 1A2 , 2B1 / 2B2 and 2E1 isoenzymes . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: In vitro studies using organic inhibitors specific for individual P450 isoenzymes and antibody inhibition experiments have further demonstrated that the increase in the activity of PROD , EROD and NDMA - d are due to the increase in the levels of P450 2B1 / 2B2 , 1A1 / 1A2 and 2E1 isoenzymes , respectively .
### Output Text: | In vitro studies using organic inhibitors specific for individual P450 isoenzymes and antibody inhibition experiments have further demonstrated that the increase in the activity of PROD , EROD and <span class="chemical">NDMA</span> - d are due to the increase in the levels of P450 2B1 / 2B2 , 1A1 / 1A2 and 2E1 isoenzymes , respectively . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Induction studies have further shown that while pretreatment of 3 - methylcholanthrene ( MC ) , an inducer of P4501A1 / 1A2 , did not produce any significant effect in the incidence of lindane induced convulsions , pretreatment with phenobarbital ( PB ) , an inducer of P450 2B1 / 2B2 or ethanol , an inducer of P450 2E1 catalysed reactions , significantly increased the incidence of lindane induced convulsions .
### Output Text: | Induction studies have further shown that while pretreatment of <span class="chemical">3 - methylcholanthrene</span> ( <span class="chemical">MC</span> ) , an inducer of P4501A1 / 1A2 , did not produce any significant effect in the incidence of <span class="chemical">lindane</span> induced convulsions , pretreatment with <span class="chemical">phenobarbital</span> ( PB ) , an inducer of P450 2B1 / 2B2 or <span class="chemical">ethanol</span> , an inducer of P450 2E1 catalysed reactions , significantly increased the incidence of <span class="chemical">lindane</span> induced convulsions . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Similarly , when the P450 - mediated metabolism of lindane was blocked by cobalt chloride incidence of convulsions was increased in animals treated with lindane indicating that lindane per se or its metabolites formed by PB or ethanol inducible P450 isoenzymes are involved in its neurobehavioral toxicity .
### Output Text: | Similarly , when the P450 - mediated metabolism of <span class="chemical">lindane</span> was blocked by <span class="chemical">cobalt chloride</span> incidence of convulsions was increased in animals treated with <span class="chemical">lindane</span> indicating that <span class="chemical">lindane</span> per se or its metabolites formed by PB or <span class="chemical">ethanol</span> inducible P450 isoenzymes are involved in its neurobehavioral toxicity . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Absolute and attributable risk of venous thromboembolism in women on combined cyproterone acetate and ethinylestradiol .
### Output Text: | Absolute and attributable risk of venous thromboembolism in women on combined <span class="chemical">cyproterone acetate</span> and <span class="chemical">ethinylestradiol</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: OBJECTIVE : To achieve absolute risk estimates of venous thromboembolism ( VTE ) among women on cyproterone acetate plus ethinylestradiol ( CPA / EE ) , and among women on combined oral contraceptives ( COCs ) .
### Output Text: | OBJECTIVE : To achieve absolute risk estimates of venous thromboembolism ( VTE ) among women on <span class="chemical">cyproterone acetate</span> plus <span class="chemical">ethinylestradiol</span> ( <span class="chemical">CPA</span> / <span class="chemical">EE</span> ) , and among women on <span class="chemical">combined oral contraceptives</span> ( <span class="chemical">COCs</span> ) . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: METHODS : From the Danish National Register of Patients ( NRP ) , 1996 to 1998 , the records of 1 . 1 million Danish women , ages 15 to 44 years , were searched for evidence of VTE .
### Output Text: | METHODS : From the Danish National Register of Patients ( NRP ) , 1996 to 1998 , the records of 1 . 1 million Danish women , ages 15 to 44 years , were searched for evidence of VTE . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: COC use was ascertained through mailed questionnaires .
### Output Text: | <span class="chemical">COC</span> use was ascertained through mailed questionnaires . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Sales statistics of COCs and CPA / EE were provided through Danish Drug Statistics .
### Output Text: | Sales statistics of <span class="chemical">COCs</span> and <span class="chemical">CPA</span> / <span class="chemical">EE</span> were provided through Danish Drug Statistics . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: RESULTS : During the time frame of the study , 330 women were found to have had VTE while on COCs .
### Output Text: | RESULTS : During the time frame of the study , 330 women were found to have had VTE while on <span class="chemical">COCs</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Of these women , 67 were on levonorgestrel - containing COCs .
### Output Text: | Of these women , 67 were on <span class="chemical">levonorgestrel</span> - containing <span class="chemical">COCs</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Eleven were on CPA / EE .
### Output Text: | Eleven were on <span class="chemical">CPA</span> / <span class="chemical">EE</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The corresponding absolute risk of VTE was 3 . 4 ( range , 3 . 1 - 3 . 8 ) per 10 000 women years among the women on COCs , 4 . 2 ( range , 3 . 2 - 5 . 2 ) per 10 000 women years among women on levonorgestrel - containing COCs , and 3 . 1 ( range , 1 . 3 - 4 . 9 ) per 10 000 women years among the women on CPA / EE .
### Output Text: | The corresponding absolute risk of VTE was 3 . 4 ( range , 3 . 1 - 3 . 8 ) per 10 000 women years among the women on <span class="chemical">COCs</span> , 4 . 2 ( range , 3 . 2 - 5 . 2 ) per 10 000 women years among women on <span class="chemical">levonorgestrel</span> - containing <span class="chemical">COCs</span> , and 3 . 1 ( range , 1 . 3 - 4 . 9 ) per 10 000 women years among the women on <span class="chemical">CPA</span> / <span class="chemical">EE</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: CONCLUSION : Our results suggest the absolute risk of VTE among Danish women on COCs is similar to that among women taking CPA / EE .
### Output Text: | CONCLUSION : Our results suggest the absolute risk of VTE among Danish women on <span class="chemical">COCs</span> is similar to that among women taking <span class="chemical">CPA</span> / <span class="chemical">EE</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Comparison of developmental toxicology of aspirin ( acetylsalicylic acid ) in rats using selected dosing paradigms .
### Output Text: | Comparison of developmental toxicology of <span class="chemical">aspirin</span> ( <span class="chemical">acetylsalicylic acid</span> ) in rats using selected dosing paradigms . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: BACKGROUND : Analysis of the literature for nonsteroidal anti - inflammatory drugs ( NSAIDs ) suggests that a low incidence of developmental anomalies occurs in rats given NSAIDs on specific days during organogenesis .
### Output Text: | BACKGROUND : Analysis of the literature for nonsteroidal anti - inflammatory drugs ( NSAIDs ) suggests that a low incidence of developmental anomalies occurs in rats given NSAIDs on specific days during organogenesis . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Aspirin ( acetylsalicylic acid [ ASA ] ) , an irreversible cyclooxygenase 1 and 2 inhibitor , induces developmental anomalies when administered to Wistar rats on gestational day ( GD ) 9 , 10 , or 11 ( Kimmel CA , Wilson JG , Schumacher HJ . Teratology 4 : 15 - 24 , 1971 ) .
### Output Text: | <span class="chemical">Aspirin</span> ( <span class="chemical">acetylsalicylic acid</span> [ <span class="chemical">ASA</span> ] ) , an irreversible cyclooxygenase 1 and 2 inhibitor , induces developmental anomalies when administered to Wistar rats on gestational day ( GD ) 9 , 10 , or 11 ( Kimmel CA , Wilson JG , Schumacher HJ . Teratology 4 : 15 - 24 , 1971 ) . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: There are no published ASA studies using the multiple dosing paradigm of GDs 6 to 17 .
### Output Text: | There are no published <span class="chemical">ASA</span> studies using the multiple dosing paradigm of GDs 6 to 17 . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Objectives of the current study were to compare results between Sprague - Dawley ( SD ) and Wistar strains when ASA is administered on GD 9 , 10 , or 11 ; to compare the malformation patterns following single and multiple dosings during organogenesis in SD rats ; and to test the hypothesis that maternal gastrointestinal toxicity confounds the detection of low incidence malformations with ASA when a multiple dosing paradigm is used .
### Output Text: | Objectives of the current study were to compare results between Sprague - Dawley ( SD ) and Wistar strains when <span class="chemical">ASA</span> is administered on GD 9 , 10 , or 11 ; to compare the malformation patterns following single and multiple dosings during organogenesis in SD rats ; and to test the hypothesis that maternal gastrointestinal toxicity confounds the detection of low incidence malformations with <span class="chemical">ASA</span> when a multiple dosing paradigm is used . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: METHODS : ASA was administered as a single dose on GD 9 ( 0 , 250 , 500 , or 625 mg / kg ) , 10 ( 0 , 500 , 625 , or 750 mg / kg ) , or 11 ( 0 , 500 , 750 , or 1000 mg / kg ) and from GD 6 to GD 17 ( 0 , 50 , 125 , or 250 mg / kg a day ) in the multiple dose study to SD rats .
### Output Text: | METHODS : <span class="chemical">ASA</span> was administered as a single dose on GD 9 ( 0 , 250 , 500 , or 625 mg / kg ) , 10 ( 0 , 500 , 625 , or 750 mg / kg ) , or 11 ( 0 , 500 , 750 , or 1000 mg / kg ) and from GD 6 to GD 17 ( 0 , 50 , 125 , or 250 mg / kg a day ) in the multiple dose study to SD rats . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Animals were killed on GD 21 , and fetuses were examined viscerally .
### Output Text: | Animals were killed on GD 21 , and fetuses were examined viscerally . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: RESULTS : The literature evaluation suggested that NSAIDs induce ventricular septal defects ( VSDs ) and midline defects ( MDs ) in rats and diaphragmatic hernia ( DH ) , MDs , and VSDs in rabbits ( Cook JC et al . , 2003 ) ; hence , the present study focused on these malformations , even though ASA induces several other low - incidence malformations .
### Output Text: | RESULTS : The literature evaluation suggested that NSAIDs induce ventricular septal defects ( VSDs ) and midline defects ( MDs ) in rats and diaphragmatic hernia ( DH ) , MDs , and VSDs in rabbits ( Cook JC et al . , 2003 ) ; hence , the present study focused on these malformations , even though <span class="chemical">ASA</span> induces several other low - incidence malformations . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: In single dose studies , DH , MD , and VSD were induced on GDs 9 and 10 .
### Output Text: | In single dose studies , DH , MD , and VSD were induced on GDs 9 and 10 . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: VSD also was noted following treatment on GD 11 .
### Output Text: | VSD also was noted following treatment on GD 11 . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: In contrast , DH and MD were noted in the multiple dose study design only in the high - dose group , and VSD was noted across all dose groups .
### Output Text: | In contrast , DH and MD were noted in the multiple dose study design only in the high - dose group , and VSD was noted across all dose groups . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: CONCLUSIONS : High concordance in major developmental anomalies between Wistar and SD rats were noted with the exception of VSD in the SD rats and hydrocephalus in the Wistar rats .
### Output Text: | CONCLUSIONS : High concordance in major developmental anomalies between Wistar and SD rats were noted with the exception of VSD in the SD rats and hydrocephalus in the Wistar rats . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Variations and malformations were similar when ASA was administered as a single dose or during the period of organogenesis ( GDs 6 to 17 ) .
### Output Text: | Variations and malformations were similar when <span class="chemical">ASA</span> was administered as a single dose or during the period of organogenesis ( GDs 6 to 17 ) . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: It was also evident that , by titrating the dose to achieve a maximum tolerated dose , malformations that normally occur at low incidence , as reported from previous single dose studies , could also be induced with ASA given at multiple doses .
### Output Text: | It was also evident that , by titrating the dose to achieve a maximum tolerated dose , malformations that normally occur at low incidence , as reported from previous single dose studies , could also be induced with <span class="chemical">ASA</span> given at multiple doses . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Reversal of central benzodiazepine effects by flumazenil after intravenous conscious sedation with diazepam and opioids : report of a double - blind multicenter study .
### Output Text: | Reversal of central <span class="chemical">benzodiazepine</span> effects by <span class="chemical">flumazenil</span> after intravenous conscious sedation with <span class="chemical">diazepam</span> and opioids : report of a double - blind multicenter study . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The Flumazenil in Intravenous Conscious Sedation with Diazepam Multicenter Study Group II .
### Output Text: | The <span class="chemical">Flumazenil</span> in Intravenous Conscious Sedation with <span class="chemical">Diazepam</span> Multicenter Study Group II . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The efficacy and safety of a new benzodiazepine antagonist , flumazenil , were assessed in a double - blind multicenter study .
### Output Text: | The efficacy and safety of a new <span class="chemical">benzodiazepine</span> antagonist , <span class="chemical">flumazenil</span> , were assessed in a double - blind multicenter study . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Flumazenil ( mean dose , 0 . 76 mg ) or placebo ( mean dose , 8 . 9 ml ) was administered intravenously to 130 and 67 patients , respectively , who had been given diazepam in conjunction with an opioid ( fentanyl , meperidine , or morphine ) for the induction and maintenance of intravenous conscious sedation for diagnostic or therapeutic surgical procedures .
### Output Text: | <span class="chemical">Flumazenil</span> ( mean dose , 0 . 76 mg ) or placebo ( mean dose , 8 . 9 ml ) was administered intravenously to 130 and 67 patients , respectively , who had been given <span class="chemical">diazepam</span> in conjunction with an opioid ( <span class="chemical">fentanyl</span> , <span class="chemical">meperidine</span> , or <span class="chemical">morphine</span> ) for the induction and maintenance of intravenous conscious sedation for diagnostic or therapeutic surgical procedures . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The group assessable for efficacy comprised 122 patients treated with flumazenil and 64 patients given placebo .
### Output Text: | The group assessable for efficacy comprised 122 patients treated with <span class="chemical">flumazenil</span> and 64 patients given placebo . |
Subsets and Splits