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clinicalnlplab
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BC5CDR_chemical_dev

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In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Early identification , eg by polymerase chain reaction of those patients at risk of disseminated adenovirus disease may permit earlier antiviral treatment and better evaluation of therapeutic response . ### Output Text:
Early identification , eg by polymerase chain reaction of those patients at risk of disseminated adenovirus disease may permit earlier antiviral treatment and better evaluation of therapeutic response .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: CONCLUSIONS : Two of 5 children with severe adenovirus disease treated with intravenous ribavirin recovered . ### Output Text:
CONCLUSIONS : Two of 5 children with severe adenovirus disease treated with intravenous <span class="chemical">ribavirin</span> recovered .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: The availability of newer rapid diagnostic techniques , such as polymerase chain reaction , may make earlier , more effective treatment of adenovirus infection possible . ### Output Text:
The availability of newer rapid diagnostic techniques , such as polymerase chain reaction , may make earlier , more effective treatment of adenovirus infection possible .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Given the seriousness and increasing prevalence of adenovirus disease in certain hosts , especially children , a large , multicenter clinical trial of potentially useful anti - adenoviral therapies , such as intravenous ribavirin , is clearly required to demonstrate the most effective and least toxic therapy . ### Output Text:
Given the seriousness and increasing prevalence of adenovirus disease in certain hosts , especially children , a large , multicenter clinical trial of potentially useful anti - adenoviral therapies , such as intravenous <span class="chemical">ribavirin</span> , is clearly required to demonstrate the most effective and least toxic therapy .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Delayed asystolic cardiac arrest after diltiazem overdose ; resuscitation with high dose intravenous calcium . ### Output Text:
Delayed asystolic cardiac arrest after <span class="chemical">diltiazem</span> overdose ; resuscitation with high dose intravenous <span class="chemical">calcium</span> .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: A 51 year old man took a mixed overdose including 1 . 8 - 3 . 6 g of diltiazem , paracetamol , aspirin , isosorbide nitrate , and alcohol . ### Output Text:
A 51 year old man took a mixed overdose including 1 . 8 - 3 . 6 g of <span class="chemical">diltiazem</span> , <span class="chemical">paracetamol</span> , <span class="chemical">aspirin</span> , <span class="chemical">isosorbide</span> <span class="chemical">nitrate</span> , and <span class="chemical">alcohol</span> .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: He initially presented to hospital after six hours with mild hypotension and was treated with activated charcoal and intravenous fluids . ### Output Text:
He initially presented to hospital after six hours with mild hypotension and was treated with activated charcoal and intravenous fluids .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Eighteen hours after the overdose he had two generalised tonic - clonic seizures . ### Output Text:
Eighteen hours after the overdose he had two generalised tonic - clonic seizures .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: The patient remained unresponsive with junctional bradycardia , unrecordable blood pressure , and then became asystolic . ### Output Text:
The patient remained unresponsive with junctional bradycardia , unrecordable blood pressure , and then became asystolic .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: He was resuscitated with high dose ( 13 . 5 g ) intravenous calcium and adrenaline ( epinephrine ) . ### Output Text:
He was resuscitated with high dose ( 13 . 5 g ) intravenous <span class="chemical">calcium</span> and <span class="chemical">adrenaline</span> ( <span class="chemical">epinephrine</span> ) .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: He required inotropic support and temporary pacing over the next 48 hours . ### Output Text:
He required inotropic support and temporary pacing over the next 48 hours .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: This case suggests there is a role for aggressive high dose intravenous calcium therapy in severe diltiazem overdose , particularly with the onset of asystole . ### Output Text:
This case suggests there is a role for aggressive high dose intravenous <span class="chemical">calcium</span> therapy in severe <span class="chemical">diltiazem</span> overdose , particularly with the onset of asystole .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: It should be considered early in cases of cardiac arrest after diltiazem overdose . ### Output Text:
It should be considered early in cases of cardiac arrest after <span class="chemical">diltiazem</span> overdose .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: The case also highlights the problems with delayed toxicity when whole bowel irrigation is not administered . ### Output Text:
The case also highlights the problems with delayed toxicity when whole bowel irrigation is not administered .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Low - molecular - weight heparin for the treatment of patients with mechanical heart valves . ### Output Text:
<span class="chemical">Low - molecular - weight heparin</span> for the treatment of patients with mechanical heart valves .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: BACKGROUND : The interruption of oral anticoagulant ( OAC ) administration is sometimes indicated in patients with mechanical heart valves , mainly before noncardiac surgery , non - surgical interventions , and pregnancy . ### Output Text:
BACKGROUND : The interruption of oral anticoagulant ( OAC ) administration is sometimes indicated in patients with mechanical heart valves , mainly before noncardiac surgery , non - surgical interventions , and pregnancy .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Unfractionated heparin ( UH ) is currently the substitute for selected patients . ### Output Text:
<span class="chemical">Unfractionated heparin</span> ( <span class="chemical">UH</span> ) is currently the substitute for selected patients .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Low - molecular - weight heparin ( LMWH ) offers theoretical advantages over UH , but is not currently considered in clinical guidelines as an alternative to UH in patients with prosthetic valves . ### Output Text:
<span class="chemical">Low - molecular - weight heparin</span> ( <span class="chemical">LMWH</span> ) offers theoretical advantages over <span class="chemical">UH</span> , but is not currently considered in clinical guidelines as an alternative to <span class="chemical">UH</span> in patients with prosthetic valves .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: HYPOTHESIS : The aim of the present study was to review the data accumulated so far on the use of LMWH in this patient population and to discuss its applicability in common practice . ### Output Text:
HYPOTHESIS : The aim of the present study was to review the data accumulated so far on the use of <span class="chemical">LMWH</span> in this patient population and to discuss its applicability in common practice .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: METHODS : For this paper , the current medical literature on LMWH in patients with mechanical heart valves was extensively reviewed . ### Output Text:
METHODS : For this paper , the current medical literature on <span class="chemical">LMWH</span> in patients with mechanical heart valves was extensively reviewed .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: RESULTS : There were eight series and six case reports . ### Output Text:
RESULTS : There were eight series and six case reports .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: None of the studies was randomized , and only one was prospective . ### Output Text:
None of the studies was randomized , and only one was prospective .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Data to establish the thromboembolic risk were incomplete . ### Output Text:
Data to establish the thromboembolic risk were incomplete .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: After excluding case reports , the following groups were constructed : ( a ) short - term administration , after valve insertion ( n = 212 ) ; ( b ) short - term , perioperative ( noncardiac ) / periprocedural ( n = 114 ) ; ( c ) long - term , due to intolerance to OAC ( n = 16 ) ; ( d ) long - term , in pregnancy ( n = 10 ) . ### Output Text:
After excluding case reports , the following groups were constructed : ( a ) short - term administration , after valve insertion ( n = 212 ) ; ( b ) short - term , perioperative ( noncardiac ) / periprocedural ( n = 114 ) ; ( c ) long - term , due to intolerance to OAC ( n = 16 ) ; ( d ) long - term , in pregnancy ( n = 10 ) .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: The incidence rate of thromboembolism was 0 . 9 % for all the studies and 0 . 5 , 0 , 20 , and 0 % in groups a , b , c , and d , respectively ; for hemorrhage , the overall rate was 3 . 4 % ( 3 . 8 , 2 . 6 , 10 , and 0 % for the respective groups ) . ### Output Text:
The incidence rate of thromboembolism was 0 . 9 % for all the studies and 0 . 5 , 0 , 20 , and 0 % in groups a , b , c , and d , respectively ; for hemorrhage , the overall rate was 3 . 4 % ( 3 . 8 , 2 . 6 , 10 , and 0 % for the respective groups ) .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: CONCLUSIONS : In patients with mechanical heart valves , short - term LMWH therapy compares favorably with UH . ### Output Text:
CONCLUSIONS : In patients with mechanical heart valves , short - term <span class="chemical">LMWH</span> therapy compares favorably with <span class="chemical">UH</span> .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Data on mid - and long - term LMWH administration in these patients are sparse . ### Output Text:
Data on mid - and long - term <span class="chemical">LMWH</span> administration in these patients are sparse .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Further randomized studies are needed to confirm the safety and precise indications for the use of LMWH in patients with mechanical heart valves . ### Output Text:
Further randomized studies are needed to confirm the safety and precise indications for the use of <span class="chemical">LMWH</span> in patients with mechanical heart valves .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Cardiac arrest after intravenous metoclopramide - a case of five repeated injections of metoclopramide causing five episodes of cardiac arrest . ### Output Text:
Cardiac arrest after intravenous <span class="chemical">metoclopramide</span> - a case of five repeated injections of <span class="chemical">metoclopramide</span> causing five episodes of cardiac arrest .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: We describe a patient where intravenous injection of metoclopramide was immediately followed by asystole repeatedly . ### Output Text:
We describe a patient where intravenous injection of <span class="chemical">metoclopramide</span> was immediately followed by asystole repeatedly .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: The patient received metoclopramide 10 mg i . v . five times during 48 h . ### Output Text:
The patient received <span class="chemical">metoclopramide</span> 10 mg i . v . five times during 48 h .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: After interviewing the attending nurses and reviewing the written documentation , it is clear that every administration of metoclopramide was immediately ( within s ) followed by asystole . ### Output Text:
After interviewing the attending nurses and reviewing the written documentation , it is clear that every administration of <span class="chemical">metoclopramide</span> was immediately ( within s ) followed by asystole .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: The asystole lasted 15 - 30 s on four occasions , on one occasion it lasted 2 min . ### Output Text:
The asystole lasted 15 - 30 s on four occasions , on one occasion it lasted 2 min .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: The patient received atropine 0 . 5 - 1 mg and chest compressions , before sinus rhythm again took over . ### Output Text:
The patient received <span class="chemical">atropine</span> 0 . 5 - 1 mg and chest compressions , before sinus rhythm again took over .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: We interpret this as episodes of cardiac arrest caused by metoclopramide . ### Output Text:
We interpret this as episodes of cardiac arrest caused by <span class="chemical">metoclopramide</span> .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: The rapid injection via the central venous route and the concomitant tapering of dopamine infusion might have contributed in precipitating the adverse drug reaction . ### Output Text:
The rapid injection via the central venous route and the concomitant tapering of <span class="chemical">dopamine</span> infusion might have contributed in precipitating the adverse drug reaction .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Immunohistochemical study on inducible type of nitric oxide ( iNOS ) , basic fibroblast growth factor ( bFGF ) and tumor growth factor - beta1 ( TGF - beta1 ) in arteritis induced in rats by fenoldopam and theophylline , vasodilators . ### Output Text:
Immunohistochemical study on inducible type of <span class="chemical">nitric oxide</span> ( iNOS ) , basic fibroblast growth factor ( bFGF ) and tumor growth factor - beta1 ( TGF - beta1 ) in arteritis induced in rats by <span class="chemical">fenoldopam</span> and <span class="chemical">theophylline</span> , vasodilators .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Arteritis induced in rats by vasodilators , fenoldopam and theophylline , was examined immunohistochemically for expressions of inducible type of nitric oxide synthase ( iNOS ) , basic fibroblast growth factor ( bFGF ) and tumor growth factor - beta1 ( TGF - beta1 ) . ### Output Text:
Arteritis induced in rats by vasodilators , <span class="chemical">fenoldopam</span> and <span class="chemical">theophylline</span> , was examined immunohistochemically for expressions of inducible type of <span class="chemical">nitric oxide</span> synthase ( iNOS ) , basic fibroblast growth factor ( bFGF ) and tumor growth factor - beta1 ( TGF - beta1 ) .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Rats were administered fenoldopam for 24 hours by intravenous infusion with or without following repeated daily oral administrations of theophylline . ### Output Text:
Rats were administered <span class="chemical">fenoldopam</span> for 24 hours by intravenous infusion with or without following repeated daily oral administrations of <span class="chemical">theophylline</span> .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Irrespective of theophylline administration , iNOS antigens were remarkably abundant in ED - 1 - positive cells on day 5 and 8 post - fenoldopam - infusion ( DPI ) ; bFGF antigens were remarkably abundant in ED - 1 - positive cells on 1 and 3 DPI ; TGF - beta1 antigens were observed in ED - 1 - positive cells on and after 5 DPI . ### Output Text:
Irrespective of <span class="chemical">theophylline</span> administration , iNOS antigens were remarkably abundant in ED - 1 - positive cells on day 5 and 8 post - <span class="chemical">fenoldopam</span> - infusion ( DPI ) ; bFGF antigens were remarkably abundant in ED - 1 - positive cells on 1 and 3 DPI ; TGF - beta1 antigens were observed in ED - 1 - positive cells on and after 5 DPI .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: These results suggest that the peak expression of iNOS antigen was followed by that of bFGF antigen , and bFGF may have a suppressive effect on iNOS expression in these rat arteritis models . ### Output Text:
These results suggest that the peak expression of iNOS antigen was followed by that of bFGF antigen , and bFGF may have a suppressive effect on iNOS expression in these rat arteritis models .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: On the other hand , TGF - beta1 was not considered to have a suppressive effect on iNOS expression in these models . ### Output Text:
On the other hand , TGF - beta1 was not considered to have a suppressive effect on iNOS expression in these models .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: The striatum as a target for anti - rigor effects of an antagonist of mGluR1 , but not an agonist of group II metabotropic glutamate receptors . ### Output Text:
The striatum as a target for anti - rigor effects of an antagonist of mGluR1 , but not an agonist of group II metabotropic <span class="chemical">glutamate</span> receptors .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: The aim of the present study was to find out whether the metabotropic receptor 1 ( mGluR1 ) and group II mGluRs , localized in the striatum , are involved in antiparkinsonian - like effects in rats . ### Output Text:
The aim of the present study was to find out whether the metabotropic receptor 1 ( mGluR1 ) and group II mGluRs , localized in the striatum , are involved in antiparkinsonian - like effects in rats .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Haloperidol ( 1 mg / kg ip ) induced parkinsonian - like muscle rigidity , measured as an increased resistance of a rat ' s hind foot to passive flexion and extension at the ankle joint . ### Output Text:
<span class="chemical">Haloperidol</span> ( 1 mg / kg ip ) induced parkinsonian - like muscle rigidity , measured as an increased resistance of a rat ' s hind foot to passive flexion and extension at the ankle joint .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: ( RS ) - 1 - aminoindan - 1 , 5 - dicarboxylic acid ( AIDA ; 0 . 5 - 15 microg / 0 . 5 microl ) , a potent and selective mGluR1 antagonist , or ( 2R , 4R ) - 4 - aminopyrrolidine - 2 , 4 - dicarboxylate ( 2R , 4R - APDC ; 7 . 5 - 15 microg / 0 . 5 microl ) , a selective group II agonist , was injected bilaterally into the striatum of haloperidol - treated animals . ### Output Text:
<span class="chemical">( RS ) - 1 - aminoindan - 1 , 5 - dicarboxylic acid</span> ( <span class="chemical">AIDA</span> ; 0 . 5 - 15 microg / 0 . 5 microl ) , a potent and selective mGluR1 antagonist , or <span class="chemical">( 2R , 4R ) - 4 - aminopyrrolidine - 2 , 4 - dicarboxylate</span> ( <span class="chemical">2R , 4R - APDC</span> ; 7 . 5 - 15 microg / 0 . 5 microl ) , a selective group II agonist , was injected bilaterally into the striatum of <span class="chemical">haloperidol</span> - treated animals .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: AIDA in doses of 7 . 5 - 15 microg / 0 . 5 microl diminished the haloperidol - induced muscle rigidity . ### Output Text:
<span class="chemical">AIDA</span> in doses of 7 . 5 - 15 microg / 0 . 5 microl diminished the <span class="chemical">haloperidol</span> - induced muscle rigidity .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: In contrast , 2R , 4R - APDC injections were ineffective . ### Output Text:
In contrast , <span class="chemical">2R , 4R - APDC</span> injections were ineffective .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: The present results may suggest that the blockade of striatal mGluR1 , but not the stimulation of group II mGluRs , may ameliorate parkinsonian muscle rigidity . ### Output Text:
The present results may suggest that the blockade of striatal mGluR1 , but not the stimulation of group II mGluRs , may ameliorate parkinsonian muscle rigidity .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: A phase II study of thalidomide in advanced metastatic renal cell carcinoma . ### Output Text:
A phase II study of <span class="chemical">thalidomide</span> in advanced metastatic renal cell carcinoma .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: OBJECTIVES : To evaluate the toxicity and activity of thalidomide in patients with advanced metastatic renal cell cancer and to measure changes of one angiogenic factor , vascular endothelial growth factor ( VEGF ) 165 , with therapy . ### Output Text:
OBJECTIVES : To evaluate the toxicity and activity of <span class="chemical">thalidomide</span> in patients with advanced metastatic renal cell cancer and to measure changes of one angiogenic factor , vascular endothelial growth factor ( VEGF ) 165 , with therapy .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: PATIENTS AND METHODS : 29 patients were enrolled on a study of thalidomide using an intra - patient dose escalation schedule . ### Output Text:
PATIENTS AND METHODS : 29 patients were enrolled on a study of <span class="chemical">thalidomide</span> using an intra - patient dose escalation schedule .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Patients began thalidomide at 400 mg / d and escalated as tolerated to 1200 mg / d by day 54 . ### Output Text:
Patients began <span class="chemical">thalidomide</span> at 400 mg / d and escalated as tolerated to 1200 mg / d by day 54 .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Fifty - nine per cent of patients had had previous therapy with IL - 2 and 52 % were performance status 2 or 3 . ### Output Text:
Fifty - nine per cent of patients had had previous therapy with IL - 2 and 52 % were performance status 2 or 3 .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Systemic plasma VEGF165 levels were measured by dual monoclonal ELISA in 8 patients . ### Output Text:
Systemic plasma VEGF165 levels were measured by dual monoclonal ELISA in 8 patients .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: RESULTS : 24 patients were evaluable for response with one partial response of 11 months duration of a patient with hepatic and pulmonary metastases ( 4 % ) , one minor response , and 2 patients stable for over 6 months . ### Output Text:
RESULTS : 24 patients were evaluable for response with one partial response of 11 months duration of a patient with hepatic and pulmonary metastases ( 4 % ) , one minor response , and 2 patients stable for over 6 months .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Somnolence and constipation were prominent toxicities and most patients could not tolerate the 1200 mg / day dose level . ### Output Text:
Somnolence and constipation were prominent toxicities and most patients could not tolerate the 1200 mg / day dose level .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Systemic plasma VEGF165 levels did not change with therapy . ### Output Text:
Systemic plasma VEGF165 levels did not change with therapy .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: CONCLUSION : These results are consistent with a low level of activity of thalidomide in renal cell carcinoma . ### Output Text:
CONCLUSION : These results are consistent with a low level of activity of <span class="chemical">thalidomide</span> in renal cell carcinoma .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Administration of doses over 800 mg / day was difficult to achieve in this patient population , however lower doses were practical . ### Output Text:
Administration of doses over 800 mg / day was difficult to achieve in this patient population , however lower doses were practical .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: The dose - response relationship , if any , of thalidomide for renal cell carcinoma is unclear . ### Output Text:
The dose - response relationship , if any , of <span class="chemical">thalidomide</span> for renal cell carcinoma is unclear .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Can lidocaine reduce succinylcholine induced postoperative myalgia ? ### Output Text:
Can <span class="chemical">lidocaine</span> reduce <span class="chemical">succinylcholine</span> induced postoperative myalgia ?
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: This study was undertaken to determine the effect of lidocaine pretreatment on reduction of succinylcholine - induced myalgia in patients undergoing general anesthesia for gynecological surgery . ### Output Text:
This study was undertaken to determine the effect of <span class="chemical">lidocaine</span> pretreatment on reduction of <span class="chemical">succinylcholine</span> - induced myalgia in patients undergoing general anesthesia for gynecological surgery .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: One hundred and thirty - five patients were assigned to one of three groups in a prospective , double blind , randomized manner . ### Output Text:
One hundred and thirty - five patients were assigned to one of three groups in a prospective , double blind , randomized manner .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Group PS , the control group , received normal saline and succinylcholine 1 . 5 mg x kg ( - 1 ) ; Group LS , lidocaine 1 . 5 mg x kg ( - 1 ) and succinylcholine 1 . 5 mg x kg ( - 1 ) ; Group PR , normal saline and rocuronium 0 . 6 mg x kg ( - 1 ) . ### Output Text:
Group PS , the control group , received normal saline and <span class="chemical">succinylcholine</span> 1 . 5 mg x kg ( - 1 ) ; Group LS , <span class="chemical">lidocaine</span> 1 . 5 mg x kg ( - 1 ) and <span class="chemical">succinylcholine</span> 1 . 5 mg x kg ( - 1 ) ; Group PR , normal saline and <span class="chemical">rocuronium</span> 0 . 6 mg x kg ( - 1 ) .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Morphine 0 . 1 mg x kg ( - 1 ) iv was given for premedication and all patients were monitored with a noninvasive blood pressure monitor , ECG and pulse oximetry . ### Output Text:
<span class="chemical">Morphine</span> 0 . 1 mg x kg ( - 1 ) iv was given for premedication and all patients were monitored with a noninvasive blood pressure monitor , ECG and pulse oximetry .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Anesthesia was induced with 5 mg . kg ( - 1 ) thiopental iv . followed by succinylcholine ( Group PS , LS ) or rocuronium ( Group PR ) for tracheal intubation . ### Output Text:
Anesthesia was induced with 5 mg . kg ( - 1 ) <span class="chemical">thiopental</span> iv . followed by <span class="chemical">succinylcholine</span> ( Group PS , LS ) or <span class="chemical">rocuronium</span> ( Group PR ) for tracheal intubation .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Following administration of these agents , the presence , and degree of fasciculation were assessed visually on a four point scale by one investigator who was blinded to the drug administered . ### Output Text:
Following administration of these agents , the presence , and degree of fasciculation were assessed visually on a four point scale by one investigator who was blinded to the drug administered .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: The blood pressure and heart rate of each patient were monitored on nine occasions . ### Output Text:
The blood pressure and heart rate of each patient were monitored on nine occasions .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Twenty - four hours later , any myalgia experienced was assessed according to a structured questionaire and graded by a four point scale by one investigator blinded to the intraoperative management . ### Output Text:
Twenty - four hours later , any myalgia experienced was assessed according to a structured questionaire and graded by a four point scale by one investigator blinded to the intraoperative management .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: The results indicate that muscle fasciculation was not found in Group PR while the patients in Group LS had a lower incidence of muscle fasciculation than those in Group PS ( p < 0 . 001 ) . ### Output Text:
The results indicate that muscle fasciculation was not found in Group PR while the patients in Group LS had a lower incidence of muscle fasciculation than those in Group PS ( p < 0 . 001 ) .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: At 24 h , the incidence of myalgia was higher in Group PS than in Group LS and PR ( p < 0 . 05 ) . ### Output Text:
At 24 h , the incidence of myalgia was higher in Group PS than in Group LS and PR ( p < 0 . 05 ) .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: A correlation was not found between the incidence of myalgia and the occurrence of muscle fasciculation . ### Output Text:
A correlation was not found between the incidence of myalgia and the occurrence of muscle fasciculation .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: The changes in systolic and diastolic blood pressure and heart rate were not significant among the three groups . ### Output Text:
The changes in systolic and diastolic blood pressure and heart rate were not significant among the three groups .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: In conclusion , where succinylcholine is used , lidocaine is proven to be the useful pretreatment agent for the reduction of postoperative myalgia . ### Output Text:
In conclusion , where <span class="chemical">succinylcholine</span> is used , <span class="chemical">lidocaine</span> is proven to be the useful pretreatment agent for the reduction of postoperative myalgia .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Reduced sodium channel density , altered voltage dependence of inactivation , and increased susceptibility to seizures in mice lacking sodium channel beta 2 - subunits . ### Output Text:
Reduced <span class="chemical">sodium</span> channel density , altered voltage dependence of inactivation , and increased susceptibility to seizures in mice lacking <span class="chemical">sodium</span> channel beta 2 - subunits .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Sodium channel beta - subunits modulate channel gating , assembly , and cell surface expression in heterologous cell systems . ### Output Text:
<span class="chemical">Sodium</span> channel beta - subunits modulate channel gating , assembly , and cell surface expression in heterologous cell systems .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: We generated beta2 ( - / - ) mice to investigate the role of beta2 in control of sodium channel density , localization , and function in neurons in vivo . ### Output Text:
We generated beta2 ( - / - ) mice to investigate the role of beta2 in control of <span class="chemical">sodium</span> channel density , localization , and function in neurons in vivo .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Measurements of [ ( 3 ) H ] saxitoxin ( STX ) binding showed a significant reduction in the level of plasma membrane sodium channels in beta2 ( - / - ) neurons . ### Output Text:
Measurements of [ ( 3 ) H ] <span class="chemical">saxitoxin</span> ( <span class="chemical">STX</span> ) binding showed a significant reduction in the level of plasma membrane <span class="chemical">sodium</span> channels in beta2 ( - / - ) neurons .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: The loss of beta2 resulted in negative shifts in the voltage dependence of inactivation as well as significant decreases in sodium current density in acutely dissociated hippocampal neurons . ### Output Text:
The loss of beta2 resulted in negative shifts in the voltage dependence of inactivation as well as significant decreases in <span class="chemical">sodium</span> current density in acutely dissociated hippocampal neurons .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: The integral of the compound action potential in optic nerve was significantly reduced , and the threshold for action potential generation was increased , indicating a reduction in the level of functional plasma membrane sodium channels . ### Output Text:
The integral of the compound action potential in optic nerve was significantly reduced , and the threshold for action potential generation was increased , indicating a reduction in the level of functional plasma membrane <span class="chemical">sodium</span> channels .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: In contrast , the conduction velocity , the number and size of axons in the optic nerve , and the specific localization of Na ( v ) 1 . 6 channels in the nodes of Ranvier were unchanged . ### Output Text:
In contrast , the conduction velocity , the number and size of axons in the optic nerve , and the specific localization of <span class="chemical">Na</span> ( v ) 1 . 6 channels in the nodes of Ranvier were unchanged .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: beta2 ( - / - ) mice displayed increased susceptibility to seizures , as indicated by reduced latency and threshold for pilocarpine - induced seizures , but seemed normal in other neurological tests . ### Output Text:
beta2 ( - / - ) mice displayed increased susceptibility to seizures , as indicated by reduced latency and threshold for <span class="chemical">pilocarpine</span> - induced seizures , but seemed normal in other neurological tests .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Our observations show that beta2 - subunits play an important role in the regulation of sodium channel density and function in neurons in vivo and are required for normal action potential generation and control of excitability . ### Output Text:
Our observations show that beta2 - subunits play an important role in the regulation of <span class="chemical">sodium</span> channel density and function in neurons in vivo and are required for normal action potential generation and control of excitability .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Acute liver failure with concurrent bupropion and carbimazole therapy . ### Output Text:
Acute liver failure with concurrent <span class="chemical">bupropion</span> and <span class="chemical">carbimazole</span> therapy .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: OBJECTIVE : To report a case of fatal liver failure possibly associated with concurrent use of bupropion and carbimazole . ### Output Text:
OBJECTIVE : To report a case of fatal liver failure possibly associated with concurrent use of <span class="chemical">bupropion</span> and <span class="chemical">carbimazole</span> .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: CASE SUMMARY : A 41 - year - old Chinese man with a history of hyperthyroidism had been treated with carbimazole and propranolol for the past 5 years . ### Output Text:
CASE SUMMARY : A 41 - year - old Chinese man with a history of hyperthyroidism had been treated with <span class="chemical">carbimazole</span> and <span class="chemical">propranolol</span> for the past 5 years .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: He received a 10 - day course of bupropion as an aid for smoking cessation 10 weeks prior to presentation . ### Output Text:
He received a 10 - day course of <span class="chemical">bupropion</span> as an aid for smoking cessation 10 weeks prior to presentation .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: He developed acute liver failure with rapid deterioration of renal function . ### Output Text:
He developed acute liver failure with rapid deterioration of renal function .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Liver biopsy showed evidence of nonspecific drug - induced acute liver injury . ### Output Text:
Liver biopsy showed evidence of nonspecific drug - induced acute liver injury .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: His condition was further complicated by sepsis and coagulopathy . ### Output Text:
His condition was further complicated by sepsis and coagulopathy .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Death resulted 19 days after the onset of symptoms . ### Output Text:
Death resulted 19 days after the onset of symptoms .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: The likelihood that bupropion induced hepatotoxicity in our patient was possible , based on the Naranjo probability scale . ### Output Text:
The likelihood that <span class="chemical">bupropion</span> induced hepatotoxicity in our patient was possible , based on the Naranjo probability scale .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: DISCUSSION : Although there is increasing evidence of hepatotoxicity induced by bupropion , this is the first case of fatality that could have resulted from acute liver failure in a patient receiving bupropion while on concomitant treatment with carbimazole . ### Output Text:
DISCUSSION : Although there is increasing evidence of hepatotoxicity induced by <span class="chemical">bupropion</span> , this is the first case of fatality that could have resulted from acute liver failure in a patient receiving <span class="chemical">bupropion</span> while on concomitant treatment with <span class="chemical">carbimazole</span> .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: CONCLUSIONS : Clinicians should be aware of the possibility of acute liver insult induced by bupropion given concurrently with other hepatotoxic drugs . ### Output Text:
CONCLUSIONS : Clinicians should be aware of the possibility of acute liver insult induced by <span class="chemical">bupropion</span> given concurrently with other hepatotoxic drugs .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: Pyeloureteral filling defects associated with systemic anticoagulation : a case report . ### Output Text:
Pyeloureteral filling defects associated with systemic anticoagulation : a case report .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: The etiology of pyeloureteritis cystica has long been attributed to chronic infection and inflammation . ### Output Text:
The etiology of pyeloureteritis cystica has long been attributed to chronic infection and inflammation .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: A case is presented that is unique in that the acute onset and the rapid resolution of pyeloureteral filling defects in this patient were documented by radiography . ### Output Text:
A case is presented that is unique in that the acute onset and the rapid resolution of pyeloureteral filling defects in this patient were documented by radiography .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: There is no evidence of antecedent or concurrent infection in this patient . ### Output Text:
There is no evidence of antecedent or concurrent infection in this patient .
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities. ### Entity Markup Guides: Use <span class="chemical"> to denote a chemical. ### Input Text: The disease occurred subsequent to the initiation of heparin therapy for suspected pelvic thrombophlebitis and cleared rapidly subsequent to its discontinuation . ### Output Text:
The disease occurred subsequent to the initiation of <span class="chemical">heparin</span> therapy for suspected pelvic thrombophlebitis and cleared rapidly subsequent to its discontinuation .