instruction
stringclasses 38
values | input
stringlengths 1
1.31k
⌀ | output
stringlengths 3
2.36k
⌀ | source
stringclasses 9
values |
|---|---|---|---|
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | Mutations of the BRCA1 gone in humans are associated with predisposition to breast and ovarian cancers . | Mutations : O
of : O
the : O
BRCA1 : O
gone : O
in : O
humans : O
are : O
associated : O
with : O
predisposition : O
to : O
breast : B
and : I
ovarian : I
cancers : I
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | We show here that Brca1 + / - mice are normal and fertile and lack tumors by age eleven months . | We : O
show : O
here : O
that : O
Brca1 : O
+ : O
/ : O
- : O
mice : O
are : O
normal : O
and : O
fertile : O
and : O
lack : O
tumors : B
by : O
age : O
eleven : O
months : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | Homozygous Brca1 ( 5 - 6 ) mutant mice die before day 7 . | Homozygous : O
Brca1 : O
( : O
5 : O
- : O
6 : O
) : O
mutant : O
mice : O
die : O
before : O
day : O
7 : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | 5 of embryogenesis . | 5 : O
of : O
embryogenesis : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | Mutant embryos are poorly developed , with no evidence of mesoderm formation . | Mutant : O
embryos : O
are : O
poorly : O
developed : O
, : O
with : O
no : O
evidence : O
of : O
mesoderm : O
formation : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | The extraembryonic region is abnormal , but aggregation with wild - type tetraploid embryos does not rescue the lethality . | The : O
extraembryonic : O
region : O
is : O
abnormal : O
, : O
but : O
aggregation : O
with : O
wild : O
- : O
type : O
tetraploid : O
embryos : O
does : O
not : O
rescue : O
the : O
lethality : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | In vivo , mutant embryos do not exhibit increased apoptosis but show reduced cell proliferation accompanied by decreased expression of cyclin E and mdm - 2 , a regulator of p53 activity . | In : O
vivo : O
, : O
mutant : O
embryos : O
do : O
not : O
exhibit : O
increased : O
apoptosis : O
but : O
show : O
reduced : O
cell : O
proliferation : O
accompanied : O
by : O
decreased : O
expression : O
of : O
cyclin : O
E : O
and : O
mdm : O
- : O
2 : O
, : O
a : O
regulator : O
of : O
p53 : O
activity : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | The expression of cyclin - dependent kinase inhibitor p21 is dramatically increased in the mutant embryos . | The : O
expression : O
of : O
cyclin : O
- : O
dependent : O
kinase : O
inhibitor : O
p21 : O
is : O
dramatically : O
increased : O
in : O
the : O
mutant : O
embryos : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | Buttressing these in vivo observations is the fact that mutant blastocyst growth is grossly impaired in vitro . | Buttressing : O
these : O
in : O
vivo : O
observations : O
is : O
the : O
fact : O
that : O
mutant : O
blastocyst : O
growth : O
is : O
grossly : O
impaired : O
in : O
vitro : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | Thus , the death of Brca1 ( 5 - 6 ) mutant embryos prior to gastrulation may be due to a failure of the proliferative burst required for the development of the different germ layers . | Thus : O
, : O
the : O
death : O
of : O
Brca1 : O
( : O
5 : O
- : O
6 : O
) : O
mutant : O
embryos : O
prior : O
to : O
gastrulation : O
may : O
be : O
due : O
to : O
a : O
failure : O
of : O
the : O
proliferative : O
burst : O
required : O
for : O
the : O
development : O
of : O
the : O
different : O
germ : O
layers : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | Increased coronary heart disease in Japanese - American men with mutation in the cholesteryl ester transfer protein gene despite increased HDL levels . | Increased : O
coronary : B
heart : I
disease : I
in : O
Japanese : O
- : O
American : O
men : O
with : O
mutation : O
in : O
the : O
cholesteryl : O
ester : O
transfer : O
protein : O
gene : O
despite : O
increased : O
HDL : O
levels : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | Plasma high density lipoprotein ( HDL ) levels are strongly genetically determined and show a general inverse relationship with coronary heart disease ( CHD ) . | Plasma : O
high : O
density : O
lipoprotein : O
( : O
HDL : O
) : O
levels : O
are : O
strongly : O
genetically : O
determined : O
and : O
show : O
a : O
general : O
inverse : O
relationship : O
with : O
coronary : B
heart : I
disease : I
( : O
CHD : B
) : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | The cholesteryl ester transfer protein ( CETP ) mediates the transfer of cholesteryl esters from HDL to other lipoproteins and is a key participant in the reverse transport of cholesterol from the periphery to the liver . | The : O
cholesteryl : O
ester : O
transfer : O
protein : O
( : O
CETP : O
) : O
mediates : O
the : O
transfer : O
of : O
cholesteryl : O
esters : O
from : O
HDL : O
to : O
other : O
lipoproteins : O
and : O
is : O
a : O
key : O
participant : O
in : O
the : O
reverse : O
transport : O
of : O
cholesterol : O
from : O
the : O
periphery : O
to : O
the : O
liver : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | A high prevalence of two different CETP gene mutations ( D442G , 5 . 1 % ; intron 14G A , 0 . 5 % ) , was found in 3 , 469 men of Japanese ancestry in the Honolulu Heart Program and mutations were associated with decreased CETP ( - 35 % ) and increased HDL chol levels ( + 10 % for D442G ) . | A : O
high : O
prevalence : O
of : O
two : O
different : O
CETP : O
gene : O
mutations : O
( : O
D442G : O
, : O
5 : O
. : O
1 : O
% : O
; : O
intron : O
14G : O
A : O
, : O
0 : O
. : O
5 : O
% : O
) : O
, : O
was : O
found : O
in : O
3 : O
, : O
469 : O
men : O
of : O
Japanese : O
ancestry : O
in : O
the : O
Honolulu : O
Heart : O
Program : O
and : O
mutations : O
were : O
associated : O
with : O
decreased : O
CETP : O
( : O
- : O
35 : O
% : O
) : O
and : O
increased : O
HDL : O
chol : O
levels : O
( : O
+ : O
10 : O
% : O
for : O
D442G : O
) : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | However , the overall prevalence of definite CHD was 21 % in men with mutations and 16 % in men without mutations . | However : O
, : O
the : O
overall : O
prevalence : O
of : O
definite : O
CHD : B
was : O
21 : O
% : O
in : O
men : O
with : O
mutations : O
and : O
16 : O
% : O
in : O
men : O
without : O
mutations : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | The relative risk ( RR ) of CHD was 1 . | The : O
relative : O
risk : O
( : O
RR : O
) : O
of : O
CHD : B
was : O
1 : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | 43 in men with mutations ( P < . 05 ) ; after adjustment for CHD risk factors , the RR was 1 . | 43 : O
in : O
men : O
with : O
mutations : O
( : O
P : O
< : O
. : O
05 : O
) : O
; : O
after : O
adjustment : O
for : O
CHD : B
risk : O
factors : O
, : O
the : O
RR : O
was : O
1 : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | 55 ( P = . 02 ) ; after additional adjustment for HDL levels , the RR was 1 . | 55 : O
( : O
P : O
= : O
. : O
02 : O
) : O
; : O
after : O
additional : O
adjustment : O
for : O
HDL : O
levels : O
, : O
the : O
RR : O
was : O
1 : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | 68 ( P = . 008 ) . | 68 : O
( : O
P : O
= : O
. : O
008 : O
) : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | Similar RR values were obtained for the D442G mutation alone . | Similar : O
RR : O
values : O
were : O
obtained : O
for : O
the : O
D442G : O
mutation : O
alone : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | Increased CHD in men with mutations was primarily observed for HDL chol 41 - 60 mg / dl ; for HDL chol > 60 mg / dl men with and without mutations had low CHD prevalence . | Increased : O
CHD : B
in : O
men : O
with : O
mutations : O
was : O
primarily : O
observed : O
for : O
HDL : O
chol : O
41 : O
- : O
60 : O
mg : O
/ : O
dl : O
; : O
for : O
HDL : O
chol : O
> : O
60 : O
mg : O
/ : O
dl : O
men : O
with : O
and : O
without : O
mutations : O
had : O
low : O
CHD : B
prevalence : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | Thus , genetic CETP deficiency appears to be an independent risk factor for CHD , primarily due to increased CHD prevalence in men with the D442G mutation and HDL cholesterol between 41 and 60 mg / dl . | Thus : O
, : O
genetic : O
CETP : B
deficiency : I
appears : O
to : O
be : O
an : O
independent : O
risk : O
factor : O
for : O
CHD : B
, : O
primarily : O
due : O
to : O
increased : O
CHD : B
prevalence : O
in : O
men : O
with : O
the : O
D442G : O
mutation : O
and : O
HDL : O
cholesterol : O
between : O
41 : O
and : O
60 : O
mg : O
/ : O
dl : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | The findings suggest that both HDL concentration and the dynamics of cholesterol transport through HDL ( i . e . , reverse cholesterol transport ) determine the anti - atherogenicity of the HDL fraction . | The : O
findings : O
suggest : O
that : O
both : O
HDL : O
concentration : O
and : O
the : O
dynamics : O
of : O
cholesterol : O
transport : O
through : O
HDL : O
( : O
i : O
. : O
e : O
. : O
, : O
reverse : O
cholesterol : O
transport : O
) : O
determine : O
the : O
anti : O
- : O
atherogenicity : O
of : O
the : O
HDL : O
fraction : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | Mapping the homolog of the human Rb1 gene to chromosome 14 of higher primates . | Mapping : O
the : O
homolog : O
of : O
the : O
human : O
Rb1 : O
gene : O
to : O
chromosome : O
14 : O
of : O
higher : O
primates : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | The Rb1 gene has been implicated with retinoblastoma and is located on human Chromosome ( Chr ) 13q14 . | The : O
Rb1 : O
gene : O
has : O
been : O
implicated : O
with : O
retinoblastoma : B
and : O
is : O
located : O
on : O
human : O
Chromosome : O
( : O
Chr : O
) : O
13q14 : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | 2 2 . | 2 : O
2 : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | A unique sequence human Rb1 cosmid DNA probe has been used to localize this region on apes Chr 14 by the FISH technique . | A : O
unique : O
sequence : O
human : O
Rb1 : O
cosmid : O
DNA : O
probe : O
has : O
been : O
used : O
to : O
localize : O
this : O
region : O
on : O
apes : O
Chr : O
14 : O
by : O
the : O
FISH : O
technique : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | The conservation of the Rb1 gene in higher primates at the corresponding equivalent chromosome locus ( 14q14 ) of the human may serve as a phylogenetic marker to further trace the evolutionary pathway of human descent . | The : O
conservation : O
of : O
the : O
Rb1 : O
gene : O
in : O
higher : O
primates : O
at : O
the : O
corresponding : O
equivalent : O
chromosome : O
locus : O
( : O
14q14 : O
) : O
of : O
the : O
human : O
may : O
serve : O
as : O
a : O
phylogenetic : O
marker : O
to : O
further : O
trace : O
the : O
evolutionary : O
pathway : O
of : O
human : O
descent : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | Wiskott - Aldrich syndrome : no strict genotype - phenotype correlations but clustering of missense mutations in the amino - terminal part of the WASP gene product . | Wiskott : B
- : I
Aldrich : I
syndrome : I
: : O
no : O
strict : O
genotype : O
- : O
phenotype : O
correlations : O
but : O
clustering : O
of : O
missense : O
mutations : O
in : O
the : O
amino : O
- : O
terminal : O
part : O
of : O
the : O
WASP : O
gene : O
product : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | The Wiskott - Aldrich syndrome protein ( WASP ) gene was found to be mutated in patients presenting with WAS and in patients showing X - linked thrombocytopenia . | The : O
Wiskott : B
- : I
Aldrich : I
syndrome : I
protein : O
( : O
WASP : O
) : O
gene : O
was : O
found : O
to : O
be : O
mutated : O
in : O
patients : O
presenting : O
with : O
WAS : B
and : O
in : O
patients : O
showing : O
X : B
- : I
linked : I
thrombocytopenia : I
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | Mutation analysis in 19 families of German , Swiss and Turkish descent by single - strand conformation polymorphism and sequencing resulted in the detection of seven novel and 10 known mutations . | Mutation : O
analysis : O
in : O
19 : O
families : O
of : O
German : O
, : O
Swiss : O
and : O
Turkish : O
descent : O
by : O
single : O
- : O
strand : O
conformation : O
polymorphism : O
and : O
sequencing : O
resulted : O
in : O
the : O
detection : O
of : O
seven : O
novel : O
and : O
10 : O
known : O
mutations : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | A striking clustering of missense mutations in the first four exons contrasted with a random distribution of nonsense mutations . | A : O
striking : O
clustering : O
of : O
missense : O
mutations : O
in : O
the : O
first : O
four : O
exons : O
contrasted : O
with : O
a : O
random : O
distribution : O
of : O
nonsense : O
mutations : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | More than 85 % of all known missense mutations were localized in the amino - terminal stretch of the WASP gene product ; this region contained a mutational hot spot at codon 86 . | More : O
than : O
85 : O
% : O
of : O
all : O
known : O
missense : O
mutations : O
were : O
localized : O
in : O
the : O
amino : O
- : O
terminal : O
stretch : O
of : O
the : O
WASP : O
gene : O
product : O
; : O
this : O
region : O
contained : O
a : O
mutational : O
hot : O
spot : O
at : O
codon : O
86 : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | No genotype - phenotype correlation emerged after a comparison of the identified mutations with the resulting clinical picture for a classical WAS phenotype . | No : O
genotype : O
- : O
phenotype : O
correlation : O
emerged : O
after : O
a : O
comparison : O
of : O
the : O
identified : O
mutations : O
with : O
the : O
resulting : O
clinical : O
picture : O
for : O
a : O
classical : O
WAS : B
phenotype : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | A substitution at codon 86 resulted in an extremely variable expression of the disease in a large Swiss family . | A : O
substitution : O
at : O
codon : O
86 : O
resulted : O
in : O
an : O
extremely : O
variable : O
expression : O
of : O
the : O
disease : O
in : O
a : O
large : O
Swiss : O
family : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | An extended homology search revealed a distant relationship of this stretch to the vasodilator - stimulated phosphoprotein ( VASP ) , which is involved in the maintenance of cyto - architecture by interacting with actin - like filaments . . | An : O
extended : O
homology : O
search : O
revealed : O
a : O
distant : O
relationship : O
of : O
this : O
stretch : O
to : O
the : O
vasodilator : O
- : O
stimulated : O
phosphoprotein : O
( : O
VASP : O
) : O
, : O
which : O
is : O
involved : O
in : O
the : O
maintenance : O
of : O
cyto : O
- : O
architecture : O
by : O
interacting : O
with : O
actin : O
- : O
like : O
filaments : O
. : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | Influence of PAX6 gene dosage on development : overexpression causes severe eye abnormalities . | Influence : O
of : O
PAX6 : O
gene : O
dosage : O
on : O
development : O
: : O
overexpression : O
causes : O
severe : O
eye : B
abnormalities : I
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | Aniridia in man and Small eye in mice are semidominant developmental disorders caused by mutations within the paired box gene PAX6 . | Aniridia : B
in : O
man : O
and : O
Small : O
eye : O
in : O
mice : O
are : O
semidominant : B
developmental : I
disorders : I
caused : O
by : O
mutations : O
within : O
the : O
paired : O
box : O
gene : O
PAX6 : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | Whereas heterozygotes suffer from iris hypoplasia , homozygous mice lack eyes and nasal cavities and exhibit brain abnormalities . | Whereas : O
heterozygotes : O
suffer : O
from : O
iris : B
hypoplasia : I
, : O
homozygous : O
mice : O
lack : O
eyes : O
and : O
nasal : O
cavities : O
and : O
exhibit : O
brain : B
abnormalities : I
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | To investigate the role of gene dosage in more detail , we have generated yeast artificial chromosome transgenic mice carrying the human PAX6 locus . | To : O
investigate : O
the : O
role : O
of : O
gene : O
dosage : O
in : O
more : O
detail : O
, : O
we : O
have : O
generated : O
yeast : O
artificial : O
chromosome : O
transgenic : O
mice : O
carrying : O
the : O
human : O
PAX6 : O
locus : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | When crossed onto the Small eye background , the transgene rescues the mutant phenotype . | When : O
crossed : O
onto : O
the : O
Small : O
eye : O
background : O
, : O
the : O
transgene : O
rescues : O
the : O
mutant : O
phenotype : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | Strikingly , mice carrying multiple copies on a wild - type background show specific developmental abnormalities of the eye , but not of other tissues expressing the gene . | Strikingly : O
, : O
mice : O
carrying : O
multiple : O
copies : O
on : O
a : O
wild : O
- : O
type : O
background : O
show : O
specific : O
developmental : B
abnormalities : I
of : I
the : I
eye : I
, : O
but : O
not : O
of : O
other : O
tissues : O
expressing : O
the : O
gene : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | Thus , at least five different eye phenotypes are associated with changes in PAX6 expression . | Thus : O
, : O
at : O
least : O
five : O
different : O
eye : O
phenotypes : O
are : O
associated : O
with : O
changes : O
in : O
PAX6 : O
expression : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | We provide evidence that not only reduced , but also increased levels of transcriptional regulators can cause developmental defects . . | We : O
provide : O
evidence : O
that : O
not : O
only : O
reduced : O
, : O
but : O
also : O
increased : O
levels : O
of : O
transcriptional : O
regulators : O
can : O
cause : O
developmental : B
defects : I
. : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | Heterodimer formation and activity in the human enzyme galactose - 1 - phosphate uridylyltransferase . | Heterodimer : O
formation : O
and : O
activity : O
in : O
the : O
human : O
enzyme : O
galactose : O
- : O
1 : O
- : O
phosphate : O
uridylyltransferase : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | One of the fundamental questions concerning expression and function of dimeric enzymes involves the impact of naturally occurring mutations on subunit assembly and heterodimer activity . | One : O
of : O
the : O
fundamental : O
questions : O
concerning : O
expression : O
and : O
function : O
of : O
dimeric : O
enzymes : O
involves : O
the : O
impact : O
of : O
naturally : O
occurring : O
mutations : O
on : O
subunit : O
assembly : O
and : O
heterodimer : O
activity : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | This question is of particular interest for the human enzyme galactose - l - phosphate uridylyl - transferase ( GALT ) , impairment of which results in the inherited metabolic disorder galactosemia , because many if not most patients studied to date are compound heterozygotes rather than true molecular homozygotes . | This : O
question : O
is : O
of : O
particular : O
interest : O
for : O
the : O
human : O
enzyme : O
galactose : O
- : O
l : O
- : O
phosphate : O
uridylyl : O
- : O
transferase : O
( : O
GALT : O
) : O
, : O
impairment : O
of : O
which : O
results : O
in : O
the : O
inherited : B
metabolic : I
disorder : I
galactosemia : B
, : O
because : O
many : O
if : O
not : O
most : O
patients : O
studied : O
to : O
date : O
are : O
compound : O
heterozygotes : O
rather : O
than : O
true : O
molecular : O
homozygotes : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | Furthermore , the broad range of phenotypic severity observed in these patients raises the possibility that allelic combination , not just allelic constitution , may play some role in determining outcome . | Furthermore : O
, : O
the : O
broad : O
range : O
of : O
phenotypic : O
severity : O
observed : O
in : O
these : O
patients : O
raises : O
the : O
possibility : O
that : O
allelic : O
combination : O
, : O
not : O
just : O
allelic : O
constitution : O
, : O
may : O
play : O
some : O
role : O
in : O
determining : O
outcome : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | In the work described herein , we have selected two distinct naturally occurring null mutations of GALT , Q188R and R333W , and asked the questions ( i ) what are the impacts of these mutations on subunit assembly , and ( ii ) if heterodimers do form , are they active ? | In : O
the : O
work : O
described : O
herein : O
, : O
we : O
have : O
selected : O
two : O
distinct : O
naturally : O
occurring : O
null : O
mutations : O
of : O
GALT : O
, : O
Q188R : O
and : O
R333W : O
, : O
and : O
asked : O
the : O
questions : O
( : O
i : O
) : O
what : O
are : O
the : O
impacts : O
of : O
these : O
mutations : O
on : O
subunit : O
assembly : O
, : O
and : O
( : O
ii : O
) : O
if : O
heterodimers : O
do : O
form : O
, : O
are : O
they : O
active : O
? : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | To answer these questions , we have established a yeast system for the coexpression of epitope - tagged alleles of human GALT and investigated both the extent of specific GALT subunit interactions and the activity of defined heterodimer pools . | To : O
answer : O
these : O
questions : O
, : O
we : O
have : O
established : O
a : O
yeast : O
system : O
for : O
the : O
coexpression : O
of : O
epitope : O
- : O
tagged : O
alleles : O
of : O
human : O
GALT : O
and : O
investigated : O
both : O
the : O
extent : O
of : O
specific : O
GALT : O
subunit : O
interactions : O
and : O
the : O
activity : O
of : O
defined : O
heterodimer : O
pools : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | We have found that both homodimers and heterodimers do form involving each of the mutant subunits tested and that both heterodimer pools retain substantial enzymatic activity . | We : O
have : O
found : O
that : O
both : O
homodimers : O
and : O
heterodimers : O
do : O
form : O
involving : O
each : O
of : O
the : O
mutant : O
subunits : O
tested : O
and : O
that : O
both : O
heterodimer : O
pools : O
retain : O
substantial : O
enzymatic : O
activity : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | These results are significant not only in terms of their implications for furthering our understanding of galactosemia and GALT holoenzyme structure - function relationships but also because the system described may serve as a model for similar studies of other complexes composed of multiple subunits . . | These : O
results : O
are : O
significant : O
not : O
only : O
in : O
terms : O
of : O
their : O
implications : O
for : O
furthering : O
our : O
understanding : O
of : O
galactosemia : B
and : O
GALT : O
holoenzyme : O
structure : O
- : O
function : O
relationships : O
but : O
also : O
because : O
the : O
system : O
described : O
may : O
serve : O
as : O
a : O
model : O
for : O
similar : O
studies : O
of : O
other : O
complexes : O
composed : O
of : O
multiple : O
subunits : O
. : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | Cleavage of huntingtin by apopain , a proapoptotic cysteine protease , is modulated by the polyglutamine tract . | Cleavage : O
of : O
huntingtin : O
by : O
apopain : O
, : O
a : O
proapoptotic : O
cysteine : O
protease : O
, : O
is : O
modulated : O
by : O
the : O
polyglutamine : O
tract : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | Apoptosis has recently been recognized as a mode of cell death in Huntington disease ( HD ) . | Apoptosis : O
has : O
recently : O
been : O
recognized : O
as : O
a : O
mode : O
of : O
cell : O
death : O
in : O
Huntington : B
disease : I
( : O
HD : B
) : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | Apopain , a human counterpart of the nematode cysteine protease death - gene product , CED - 3 , has a key role in proteolytic events leading to apoptosis . | Apopain : O
, : O
a : O
human : O
counterpart : O
of : O
the : O
nematode : O
cysteine : O
protease : O
death : O
- : O
gene : O
product : O
, : O
CED : O
- : O
3 : O
, : O
has : O
a : O
key : O
role : O
in : O
proteolytic : O
events : O
leading : O
to : O
apoptosis : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | Here we show that apoptotic extracts and apopain itself specifically cleave the HD gene product , huntingtin . | Here : O
we : O
show : O
that : O
apoptotic : O
extracts : O
and : O
apopain : O
itself : O
specifically : O
cleave : O
the : O
HD : B
gene : O
product : O
, : O
huntingtin : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | The rate of cleavage increases with the length of the huntingtin polyglutamine tract , providing an explanation for the gain - of - function associated with CAG expansion . | The : O
rate : O
of : O
cleavage : O
increases : O
with : O
the : O
length : O
of : O
the : O
huntingtin : O
polyglutamine : O
tract : O
, : O
providing : O
an : O
explanation : O
for : O
the : O
gain : O
- : O
of : O
- : O
function : O
associated : O
with : O
CAG : O
expansion : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | Our results show that huntingtin is cleaved by cysteine proteases and suggest that HD might be a disorder of inappropriate apoptosis . . | Our : O
results : O
show : O
that : O
huntingtin : O
is : O
cleaved : O
by : O
cysteine : O
proteases : O
and : O
suggest : O
that : O
HD : B
might : O
be : O
a : O
disorder : B
of : I
inappropriate : I
apoptosis : I
. : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | The 5 ' end of the BRCA1 gene lies within a duplicated region of human chromosome 17q21 . | The : O
5 : O
' : O
end : O
of : O
the : O
BRCA1 : O
gene : O
lies : O
within : O
a : O
duplicated : O
region : O
of : O
human : O
chromosome : O
17q21 : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | To begin to address the hypothesis that abnormal regulation of the breast / ovarian cancer susceptibility gene BRCA1 is a critical step in sporadic breast / ovarian tumorigenesis , we have determined the detailed structure of the BRCA1 genomic region . | To : O
begin : O
to : O
address : O
the : O
hypothesis : O
that : O
abnormal : O
regulation : O
of : O
the : O
breast : B
/ : I
ovarian : I
cancer : I
susceptibility : O
gene : O
BRCA1 : O
is : O
a : O
critical : O
step : O
in : O
sporadic : O
breast : O
/ : O
ovarian : O
tumorigenesis : O
, : O
we : O
have : O
determined : O
the : O
detailed : O
structure : O
of : O
the : O
BRCA1 : O
genomic : O
region : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | We show that this region of the genome contains a tandem duplication of approximately 30 kilobases , which results in two copies of BRCA1 exons 1 and 2 , of exons 1 and 3 of the adjacent 1A1 - 3B gene and of the previously reported 295 base pair intergenic region . | We : O
show : O
that : O
this : O
region : O
of : O
the : O
genome : O
contains : O
a : O
tandem : O
duplication : O
of : O
approximately : O
30 : O
kilobases : O
, : O
which : O
results : O
in : O
two : O
copies : O
of : O
BRCA1 : O
exons : O
1 : O
and : O
2 : O
, : O
of : O
exons : O
1 : O
and : O
3 : O
of : O
the : O
adjacent : O
1A1 : O
- : O
3B : O
gene : O
and : O
of : O
the : O
previously : O
reported : O
295 : O
base : O
pair : O
intergenic : O
region : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | Sequence analysis of the duplicated exons of BRCA1 and 1A1 - 3B and flanking genomic DNA reveals maintenance of the intron - exon structure and a high degree of nucleotide sequence identity , suggesting that these are non - processed pseudogenes and that the duplication is a recent event in evolutionary terms . | Sequence : O
analysis : O
of : O
the : O
duplicated : O
exons : O
of : O
BRCA1 : O
and : O
1A1 : O
- : O
3B : O
and : O
flanking : O
genomic : O
DNA : O
reveals : O
maintenance : O
of : O
the : O
intron : O
- : O
exon : O
structure : O
and : O
a : O
high : O
degree : O
of : O
nucleotide : O
sequence : O
identity : O
, : O
suggesting : O
that : O
these : O
are : O
non : O
- : O
processed : O
pseudogenes : O
and : O
that : O
the : O
duplication : O
is : O
a : O
recent : O
event : O
in : O
evolutionary : O
terms : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | We also show that a processed pseudogene of the acidic ribosomal phosphoprotein P1 ( ARPP1 ) is inserted directly upstream of pseudo - BRCA1 exon 1A . | We : O
also : O
show : O
that : O
a : O
processed : O
pseudogene : O
of : O
the : O
acidic : O
ribosomal : O
phosphoprotein : O
P1 : O
( : O
ARPP1 : O
) : O
is : O
inserted : O
directly : O
upstream : O
of : O
pseudo : O
- : O
BRCA1 : O
exon : O
1A : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | We believe that these findings could not only confound BRCA1 mutation analysis , but could have implications for the normal and abnormal regulation of BRCA1 transcription , translation and function . . | We : O
believe : O
that : O
these : O
findings : O
could : O
not : O
only : O
confound : O
BRCA1 : O
mutation : O
analysis : O
, : O
but : O
could : O
have : O
implications : O
for : O
the : O
normal : O
and : O
abnormal : O
regulation : O
of : O
BRCA1 : O
transcription : O
, : O
translation : O
and : O
function : O
. : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | Deletion of small nuclear ribonucleoprotein polypeptide N ( SNRPN ) in Prader - Willi syndrome detected by fluorescence in situ hybridization : two sibs with the typical phenotype without a cytogenetic deletion in chromosome 15q . | Deletion : O
of : O
small : O
nuclear : O
ribonucleoprotein : O
polypeptide : O
N : O
( : O
SNRPN : O
) : O
in : O
Prader : B
- : I
Willi : I
syndrome : I
detected : O
by : O
fluorescence : O
in : O
situ : O
hybridization : O
: : O
two : O
sibs : O
with : O
the : O
typical : O
phenotype : O
without : O
a : O
cytogenetic : O
deletion : O
in : O
chromosome : O
15q : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | The small nuclear ribonucleoprotein polypeptide N ( SNRPN ) gene is regarded as one of the candidates for Prader - Willi syndrome ( PWS ) . | The : O
small : O
nuclear : O
ribonucleoprotein : O
polypeptide : O
N : O
( : O
SNRPN : O
) : O
gene : O
is : O
regarded : O
as : O
one : O
of : O
the : O
candidates : O
for : O
Prader : B
- : I
Willi : I
syndrome : I
( : O
PWS : B
) : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | We describe two sibs with typical PWS presenting deletion of SNRPN detected by fluorescence in situ hybridization ( FISH ) . | We : O
describe : O
two : O
sibs : O
with : O
typical : O
PWS : B
presenting : O
deletion : O
of : O
SNRPN : O
detected : O
by : O
fluorescence : O
in : O
situ : O
hybridization : O
( : O
FISH : O
) : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | Neither a cytogenetically detectable 15q12 deletion nor a deletion for the D15S11 , D15S10 , and GABRB3 cosmid probes were found in either patient . | Neither : O
a : O
cytogenetically : O
detectable : O
15q12 : O
deletion : O
nor : O
a : O
deletion : O
for : O
the : O
D15S11 : O
, : O
D15S10 : O
, : O
and : O
GABRB3 : O
cosmid : O
probes : O
were : O
found : O
in : O
either : O
patient : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | This implies a smaller deletion limited to the PWS critical region . | This : O
implies : O
a : O
smaller : O
deletion : O
limited : O
to : O
the : O
PWS : B
critical : O
region : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | FISH with a SNRPN probe will permit analysis of PWS patients with limited deletions not detectable with other probes . . | FISH : O
with : O
a : O
SNRPN : O
probe : O
will : O
permit : O
analysis : O
of : O
PWS : B
patients : O
with : O
limited : O
deletions : O
not : O
detectable : O
with : O
other : O
probes : O
. : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | Expression of the von Hippel - Lindau disease tumour suppressor gene during human embryogenesis . | Expression : O
of : O
the : O
von : B
Hippel : I
- : I
Lindau : I
disease : I
tumour : I
suppressor : O
gene : O
during : O
human : O
embryogenesis : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | The von Hippel - Lindau ( VHL ) disease product is thought to down - regulate transcription by antagonizing elongin - enhanced transcriptional elongation . | The : O
von : B
Hippel : I
- : I
Lindau : I
( : I
VHL : I
) : I
disease : I
product : O
is : O
thought : O
to : O
down : O
- : O
regulate : O
transcription : O
by : O
antagonizing : O
elongin : O
- : O
enhanced : O
transcriptional : O
elongation : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | Germline VHL gene mutations predispose to the development of retinal , cerebellar and spinal haemangioblastomas , renal cell carcinoma and phaeochromocytoma . | Germline : O
VHL : B
gene : O
mutations : O
predispose : O
to : O
the : O
development : O
of : O
retinal : B
, : I
cerebellar : I
and : I
spinal : I
haemangioblastomas : I
, : O
renal : B
cell : I
carcinoma : I
and : O
phaeochromocytoma : B
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | In addition , somatic Inactivation of the VHL gene is frequent in sporadic renal cell carcinoma and haemangioblastoma . | In : O
addition : O
, : O
somatic : O
Inactivation : O
of : O
the : O
VHL : B
gene : O
is : O
frequent : O
in : O
sporadic : B
renal : I
cell : I
carcinoma : I
and : O
haemangioblastoma : B
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | Regulation of transcript elongation is an important control mechanism for gene expression and the VHL gene might modify the expression of proto - oncogenes and growth suppressor genes during embryogenesis . | Regulation : O
of : O
transcript : O
elongation : O
is : O
an : O
important : O
control : O
mechanism : O
for : O
gene : O
expression : O
and : O
the : O
VHL : B
gene : O
might : O
modify : O
the : O
expression : O
of : O
proto : O
- : O
oncogenes : O
and : O
growth : O
suppressor : O
genes : O
during : O
embryogenesis : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | We therefore investigated the expression of VHL mRNA during human embryogenesis by in situ hybridization studies at 4 , 6 and 10 weeks post conception . | We : O
therefore : O
investigated : O
the : O
expression : O
of : O
VHL : B
mRNA : O
during : O
human : O
embryogenesis : O
by : O
in : O
situ : O
hybridization : O
studies : O
at : O
4 : O
, : O
6 : O
and : O
10 : O
weeks : O
post : O
conception : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | Although VHL mRNA was expressed in all three germ layers , strong expression was noted in the central nervous system , kidneys , testis and lung . | Although : O
VHL : B
mRNA : O
was : O
expressed : O
in : O
all : O
three : O
germ : O
layers : O
, : O
strong : O
expression : O
was : O
noted : O
in : O
the : O
central : O
nervous : O
system : O
, : O
kidneys : O
, : O
testis : O
and : O
lung : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | Within the kidney , VHL mRNA was differentially expressed within renal tubules suggesting that the VHL gene product may have a specific role in kidney development . | Within : O
the : O
kidney : O
, : O
VHL : B
mRNA : O
was : O
differentially : O
expressed : O
within : O
renal : O
tubules : O
suggesting : O
that : O
the : O
VHL : B
gene : O
product : O
may : O
have : O
a : O
specific : O
role : O
in : O
kidney : O
development : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | Two alternatively spliced VHL mRNAs characterized by inclusion ( isoform I ) or exclusion ( isoform II ) of exon 2 are transcribed in adult tissues . | Two : O
alternatively : O
spliced : O
VHL : B
mRNAs : O
characterized : O
by : O
inclusion : O
( : O
isoform : O
I : O
) : O
or : O
exclusion : O
( : O
isoform : O
II : O
) : O
of : O
exon : O
2 : O
are : O
transcribed : O
in : O
adult : O
tissues : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | To investigate if the two isoforms are differentially expressed during embryogenesis , VHL mRNA was reverse transcribed from 13 fetal tissues ( 8 - 10 weeks gestation ) . | To : O
investigate : O
if : O
the : O
two : O
isoforms : O
are : O
differentially : O
expressed : O
during : O
embryogenesis : O
, : O
VHL : B
mRNA : O
was : O
reverse : O
transcribed : O
from : O
13 : O
fetal : O
tissues : O
( : O
8 : O
- : O
10 : O
weeks : O
gestation : O
) : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | The quantitative distribution of VHL mRNA within fetal tissues reflected that seen by in situ hybridization and the ratio of the two VHL isoforms was similar between tissues . | The : O
quantitative : O
distribution : O
of : O
VHL : B
mRNA : O
within : O
fetal : O
tissues : O
reflected : O
that : O
seen : O
by : O
in : O
situ : O
hybridization : O
and : O
the : O
ratio : O
of : O
the : O
two : O
VHL : B
isoforms : O
was : O
similar : O
between : O
tissues : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | Although the genes regulated by the VHL gene product have not yet been identified , our findings are compatible with the hypothesis that VHL - mediated control of transcriptional elongation may have a role in normal human development . . | Although : O
the : O
genes : O
regulated : O
by : O
the : O
VHL : B
gene : O
product : O
have : O
not : O
yet : O
been : O
identified : O
, : O
our : O
findings : O
are : O
compatible : O
with : O
the : O
hypothesis : O
that : O
VHL : B
- : O
mediated : O
control : O
of : O
transcriptional : O
elongation : O
may : O
have : O
a : O
role : O
in : O
normal : O
human : O
development : O
. : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | Genetic heterogeneity in hereditary breast cancer : role of BRCA1 and BRCA2 . | Genetic : O
heterogeneity : O
in : O
hereditary : B
breast : I
cancer : I
: : O
role : O
of : O
BRCA1 : O
and : O
BRCA2 : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | The common hereditary forms of breast cancer have been largely attributed to the inheritance of mutations in the BRCA1 or BRCA2 genes . | The : O
common : O
hereditary : O
forms : O
of : O
breast : B
cancer : I
have : O
been : O
largely : O
attributed : O
to : O
the : O
inheritance : O
of : O
mutations : O
in : O
the : O
BRCA1 : O
or : O
BRCA2 : O
genes : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | However , it is not yet clear what proportion of hereditary breast cancer is explained by BRCA1 and BRCA2 or by some other unidentified susceptibility gene ( s ) . | However : O
, : O
it : O
is : O
not : O
yet : O
clear : O
what : O
proportion : O
of : O
hereditary : B
breast : I
cancer : I
is : O
explained : O
by : O
BRCA1 : O
and : O
BRCA2 : O
or : O
by : O
some : O
other : O
unidentified : O
susceptibility : O
gene : O
( : O
s : O
) : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | We describe the proportion of hereditary breast cancer explained by BRCA1 or BRCA2 in a sample of North American hereditary breast cancers and assess the evidence for additional susceptibility genes that may confer hereditary breast or ovarian cancer risk . | We : O
describe : O
the : O
proportion : O
of : O
hereditary : B
breast : I
cancer : I
explained : O
by : O
BRCA1 : O
or : O
BRCA2 : O
in : O
a : O
sample : O
of : O
North : O
American : O
hereditary : B
breast : I
cancers : I
and : O
assess : O
the : O
evidence : O
for : O
additional : O
susceptibility : O
genes : O
that : O
may : O
confer : O
hereditary : B
breast : I
or : I
ovarian : I
cancer : I
risk : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | Twenty - three families were identified through two high - risk breast cancer research programs . | Twenty : O
- : O
three : O
families : O
were : O
identified : O
through : O
two : O
high : O
- : O
risk : O
breast : B
cancer : I
research : O
programs : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | Genetic analysis was undertaken to establish linkage between the breast or ovarian cancer cases and markers on chromosomes 17q ( BRCA1 ) and 13q ( BRCA2 ) . | Genetic : O
analysis : O
was : O
undertaken : O
to : O
establish : O
linkage : O
between : O
the : O
breast : B
or : I
ovarian : I
cancer : I
cases : O
and : O
markers : O
on : O
chromosomes : O
17q : O
( : O
BRCA1 : O
) : O
and : O
13q : O
( : O
BRCA2 : O
) : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | Mutation analysis in the BRCA1 and BRCA2 genes was also undertaken in all families . | Mutation : O
analysis : O
in : O
the : O
BRCA1 : O
and : O
BRCA2 : O
genes : O
was : O
also : O
undertaken : O
in : O
all : O
families : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | The pattern of hereditary cancer in 14 ( 61 % ) of the 23 families studied was attributed to BRCA1 by a combination of linkage and mutation analyses . | The : O
pattern : O
of : O
hereditary : B
cancer : I
in : O
14 : O
( : O
61 : O
% : O
) : O
of : O
the : O
23 : O
families : O
studied : O
was : O
attributed : O
to : O
BRCA1 : O
by : O
a : O
combination : O
of : O
linkage : O
and : O
mutation : O
analyses : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | No families were attributed to BRCA2 . | No : O
families : O
were : O
attributed : O
to : O
BRCA2 : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | Five families ( 22 % ) provided evidence against linkage to both BRCA1 and BRCA2 . | Five : O
families : O
( : O
22 : O
% : O
) : O
provided : O
evidence : O
against : O
linkage : O
to : O
both : O
BRCA1 : O
and : O
BRCA2 : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | No BRCA1 or BRCA2 mutations were detected in these five families . | No : O
BRCA1 : O
or : O
BRCA2 : O
mutations : O
were : O
detected : O
in : O
these : O
five : O
families : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | The BRCA1 or BRCA2 status of four families ( 17 % ) could not be determined . | The : O
BRCA1 : O
or : O
BRCA2 : O
status : O
of : O
four : O
families : O
( : O
17 : O
% : O
) : O
could : O
not : O
be : O
determined : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | BRCA1 and BRCA2 probably explain the majority of hereditary breast cancer that exists in the North American population . | BRCA1 : O
and : O
BRCA2 : O
probably : O
explain : O
the : O
majority : O
of : O
hereditary : B
breast : I
cancer : I
that : O
exists : O
in : O
the : O
North : O
American : O
population : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | However , one or more additional genes may yet be found that explain some proportion of hereditary breast cancer . . | However : O
, : O
one : O
or : O
more : O
additional : O
genes : O
may : O
yet : O
be : O
found : O
that : O
explain : O
some : O
proportion : O
of : O
hereditary : B
breast : I
cancer : I
. : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | An intronic mutation in a lariat branchpoint sequence is a direct cause of an inherited human disorder ( fish - eye disease ) . | An : O
intronic : O
mutation : O
in : O
a : O
lariat : O
branchpoint : O
sequence : O
is : O
a : O
direct : O
cause : O
of : O
an : O
inherited : B
human : I
disorder : I
( : O
fish : B
- : I
eye : I
disease : I
) : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | The first step in the splicing of an intron from nuclear precursors of mRNA results in the formation of a lariat structure . | The : O
first : O
step : O
in : O
the : O
splicing : O
of : O
an : O
intron : O
from : O
nuclear : O
precursors : O
of : O
mRNA : O
results : O
in : O
the : O
formation : O
of : O
a : O
lariat : O
structure : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | A distinct intronic nucleotide sequence , known as the branchpoint region , plays a central role in this process . | A : O
distinct : O
intronic : O
nucleotide : O
sequence : O
, : O
known : O
as : O
the : O
branchpoint : O
region : O
, : O
plays : O
a : O
central : O
role : O
in : O
this : O
process : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | We here describe a point mutation in such a sequence . | We : O
here : O
describe : O
a : O
point : O
mutation : O
in : O
such : O
a : O
sequence : O
. : O | NCBI-disease |
Subsets and Splits