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Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | Analysis of the intragenic polymorphism D17S855 supports common origins of the mutations . | Analysis : O
of : O
the : O
intragenic : O
polymorphism : O
D17S855 : O
supports : O
common : O
origins : O
of : O
the : O
mutations : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | Eleven of the 15 kindreds manifesting BRCA1 mutations were breast - ovarian cancer families , several of them with a predominant ovarian cancer phenotype . | Eleven : O
of : O
the : O
15 : O
kindreds : O
manifesting : O
BRCA1 : O
mutations : O
were : O
breast : B
- : I
ovarian : I
cancer : I
families : O
, : O
several : O
of : O
them : O
with : O
a : O
predominant : O
ovarian : B
cancer : I
phenotype : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | The set of 32 families in which no BRCA1 alterations were detected included 1 breast - ovarian cancer kindred manifesting clear linkage to the BRCA1 region and loss of the wild - type chromosome in associated tumors . | The : O
set : O
of : O
32 : O
families : O
in : O
which : O
no : O
BRCA1 : O
alterations : O
were : O
detected : O
included : O
1 : O
breast : B
- : I
ovarian : I
cancer : I
kindred : O
manifesting : O
clear : O
linkage : O
to : O
the : O
BRCA1 : O
region : O
and : O
loss : O
of : O
the : O
wild : O
- : O
type : O
chromosome : O
in : O
associated : O
tumors : B
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | Other tumor types found in BRCA1 mutation / haplotype carriers included prostatic , pancreas , skin , and lung cancer , a malignant melanoma , an oligodendroglioma , and a carcinosarcoma . | Other : O
tumor : B
types : O
found : O
in : O
BRCA1 : O
mutation : O
/ : O
haplotype : O
carriers : O
included : O
prostatic : B
, : I
pancreas : I
, : I
skin : I
, : I
and : I
lung : I
cancer : I
, : O
a : O
malignant : B
melanoma : I
, : O
an : O
oligodendroglioma : B
, : O
and : O
a : O
carcinosarcoma : B
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | In all , 12 of 16 kindreds manifesting BRCA1 mutation or linkage contained ovarian cancer , as compared with only 6 of the remaining 31 families ( P < . 001 ) . | In : O
all : O
, : O
12 : O
of : O
16 : O
kindreds : O
manifesting : O
BRCA1 : O
mutation : O
or : O
linkage : O
contained : O
ovarian : B
cancer : I
, : O
as : O
compared : O
with : O
only : O
6 : O
of : O
the : O
remaining : O
31 : O
families : O
( : O
P : O
< : O
. : O
001 : O
) : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | The present study confirms the involvement of BRCA1 in disease predisposition for a subset of hereditary breast cancer families often characterized by ovarian cancers . | The : O
present : O
study : O
confirms : O
the : O
involvement : O
of : O
BRCA1 : O
in : O
disease : O
predisposition : O
for : O
a : O
subset : O
of : O
hereditary : B
breast : I
cancer : I
families : O
often : O
characterized : O
by : O
ovarian : B
cancers : I
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | Rapid detection of regionally clustered germ - line BRCA1 mutations by multiplex heteroduplex analysis . | Rapid : O
detection : O
of : O
regionally : O
clustered : O
germ : O
- : O
line : O
BRCA1 : O
mutations : O
by : O
multiplex : O
heteroduplex : O
analysis : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | UKCCCR Familial Ovarian Cancer Study Group . | UKCCCR : O
Familial : O
Ovarian : B
Cancer : I
Study : O
Group : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | Germ - line mutations of the BRCA1 gene are responsible for a substantial proportion of families with multiple cases of early - onset breast and / or ovarian cancer . | Germ : O
- : O
line : O
mutations : O
of : O
the : O
BRCA1 : O
gene : O
are : O
responsible : O
for : O
a : O
substantial : O
proportion : O
of : O
families : O
with : O
multiple : O
cases : O
of : O
early : O
- : O
onset : O
breast : B
and : I
/ : I
or : I
ovarian : I
cancer : I
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | Since the isolation of BRCA1 last year , > 65 distinct mutations scattered throughout the coding region have been detected , making analysis of the gene time consuming and technically challenging . | Since : O
the : O
isolation : O
of : O
BRCA1 : O
last : O
year : O
, : O
> : O
65 : O
distinct : O
mutations : O
scattered : O
throughout : O
the : O
coding : O
region : O
have : O
been : O
detected : O
, : O
making : O
analysis : O
of : O
the : O
gene : O
time : O
consuming : O
and : O
technically : O
challenging : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | We have developed a multiplex heteroduplex analysis that is designed to analyze one - quarter of the coding sequence in a single - step screening procedure and that will detect approximately 50 % of all BRCA1 mutations so far reported in breast / ovarian cancer families . | We : O
have : O
developed : O
a : O
multiplex : O
heteroduplex : O
analysis : O
that : O
is : O
designed : O
to : O
analyze : O
one : O
- : O
quarter : O
of : O
the : O
coding : O
sequence : O
in : O
a : O
single : O
- : O
step : O
screening : O
procedure : O
and : O
that : O
will : O
detect : O
approximately : O
50 : O
% : O
of : O
all : O
BRCA1 : O
mutations : O
so : O
far : O
reported : O
in : O
breast : B
/ : I
ovarian : I
cancer : I
families : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | We have used this technique to analyze BRCA1 in 162 families with a history of breast and / or ovarian cancer and identified 12 distinct mutations in 35 families . . | We : O
have : O
used : O
this : O
technique : O
to : O
analyze : O
BRCA1 : O
in : O
162 : O
families : O
with : O
a : O
history : O
of : O
breast : B
and : I
/ : I
or : I
ovarian : I
cancer : I
and : O
identified : O
12 : O
distinct : O
mutations : O
in : O
35 : O
families : O
. : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | A previously undescribed mutation within the tetramerisation domain of TP53 in a family with Li - Fraumeni syndrome . | A : O
previously : O
undescribed : O
mutation : O
within : O
the : O
tetramerisation : O
domain : O
of : O
TP53 : O
in : O
a : O
family : O
with : O
Li : B
- : I
Fraumeni : I
syndrome : I
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | We report details of a family with classic Li - Fraumeni syndrome in which there is a mutation in codon 344 of the tumour suppressor gene TP53 . | We : O
report : O
details : O
of : O
a : O
family : O
with : O
classic : O
Li : B
- : I
Fraumeni : I
syndrome : I
in : O
which : O
there : O
is : O
a : O
mutation : O
in : O
codon : O
344 : O
of : O
the : O
tumour : B
suppressor : O
gene : O
TP53 : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | Codon 344 is a key residue within the tetramerisation domain , and the amino acid substitution of a proline for a leucine is predicted to have profound implications for tetramerisation and potentially DNA binding . | Codon : O
344 : O
is : O
a : O
key : O
residue : O
within : O
the : O
tetramerisation : O
domain : O
, : O
and : O
the : O
amino : O
acid : O
substitution : O
of : O
a : O
proline : O
for : O
a : O
leucine : O
is : O
predicted : O
to : O
have : O
profound : O
implications : O
for : O
tetramerisation : O
and : O
potentially : O
DNA : O
binding : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | This is the first report of a mutation at this residue in either sporadic tumours or in the germline and the first report of a germline mutation within the tetramerisation domain . | This : O
is : O
the : O
first : O
report : O
of : O
a : O
mutation : O
at : O
this : O
residue : O
in : O
either : O
sporadic : B
tumours : I
or : O
in : O
the : O
germline : O
and : O
the : O
first : O
report : O
of : O
a : O
germline : O
mutation : O
within : O
the : O
tetramerisation : O
domain : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | The family does not appear to be remarkable in the spectrum of tumours , and there is loss of the wild - type allele in a leiomyosarcoma from the proband . | The : O
family : O
does : O
not : O
appear : O
to : O
be : O
remarkable : O
in : O
the : O
spectrum : O
of : O
tumours : B
, : O
and : O
there : O
is : O
loss : O
of : O
the : O
wild : O
- : O
type : O
allele : O
in : O
a : O
leiomyosarcoma : B
from : O
the : O
proband : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | A cell line has been established from the tumour of the proband and cytogenetic and molecular studies carried out , providing an extensive analysis in this family . . | A : O
cell : O
line : O
has : O
been : O
established : O
from : O
the : O
tumour : B
of : O
the : O
proband : O
and : O
cytogenetic : O
and : O
molecular : O
studies : O
carried : O
out : O
, : O
providing : O
an : O
extensive : O
analysis : O
in : O
this : O
family : O
. : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | The spectrum of RB1 germ - line mutations in hereditary retinoblastoma . | The : O
spectrum : O
of : O
RB1 : O
germ : O
- : O
line : O
mutations : O
in : O
hereditary : B
retinoblastoma : I
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | We have searched for germ - line RB1 mutations in 119 patients with hereditary retinoblastoma . | We : O
have : O
searched : O
for : O
germ : O
- : O
line : O
RB1 : O
mutations : O
in : O
119 : O
patients : O
with : O
hereditary : B
retinoblastoma : I
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | Previous investigations by Southern blot hybridization and PCR fragment - length analysis had revealed mutations in 48 patients . | Previous : O
investigations : O
by : O
Southern : O
blot : O
hybridization : O
and : O
PCR : O
fragment : O
- : O
length : O
analysis : O
had : O
revealed : O
mutations : O
in : O
48 : O
patients : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | Here we report on the analysis of the remaining 71 patients . | Here : O
we : O
report : O
on : O
the : O
analysis : O
of : O
the : O
remaining : O
71 : O
patients : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | By applying heteroduplex analysis , nonisotopic SSCP , and direct sequencing , we detected germ - line mutations resulting in premature termination codons or disruption of splice signals in 51 ( 72 % ) of the 71 patients . | By : O
applying : O
heteroduplex : O
analysis : O
, : O
nonisotopic : O
SSCP : O
, : O
and : O
direct : O
sequencing : O
, : O
we : O
detected : O
germ : O
- : O
line : O
mutations : O
resulting : O
in : O
premature : O
termination : O
codons : O
or : O
disruption : O
of : O
splice : O
signals : O
in : O
51 : O
( : O
72 : O
% : O
) : O
of : O
the : O
71 : O
patients : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | Four patients also showed rare sequence variants . | Four : O
patients : O
also : O
showed : O
rare : O
sequence : O
variants : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | No region of the RB1 gene was preferentially involved in single base substitutions . | No : O
region : O
of : O
the : O
RB1 : O
gene : O
was : O
preferentially : O
involved : O
in : O
single : O
base : O
substitutions : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | Recurrent transitions were observed at most of the 14 codons within the RB1 . | Recurrent : O
transitions : O
were : O
observed : O
at : O
most : O
of : O
the : O
14 : O
codons : O
within : O
the : O
RB1 : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | No mutation was observed in exons 25 - 27 , although this region contains two CGA codons . | No : O
mutation : O
was : O
observed : O
in : O
exons : O
25 : O
- : O
27 : O
, : O
although : O
this : O
region : O
contains : O
two : O
CGA : O
codons : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | This suggests that mutations within the 3 - terminal region of the RB1 gene may not be oncogenic . | This : O
suggests : O
that : O
mutations : O
within : O
the : O
3 : O
- : O
terminal : O
region : O
of : O
the : O
RB1 : O
gene : O
may : O
not : O
be : O
oncogenic : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | When these data were combined with the results of our previous investigations , mutations were identified in a total of 99 ( 83 % ) of 119 patients . | When : O
these : O
data : O
were : O
combined : O
with : O
the : O
results : O
of : O
our : O
previous : O
investigations : O
, : O
mutations : O
were : O
identified : O
in : O
a : O
total : O
of : O
99 : O
( : O
83 : O
% : O
) : O
of : O
119 : O
patients : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | The spectrum comprises 15 % large deletions , 26 % small length alterations , and 42 % base substitutions . | The : O
spectrum : O
comprises : O
15 : O
% : O
large : O
deletions : O
, : O
26 : O
% : O
small : O
length : O
alterations : O
, : O
and : O
42 : O
% : O
base : O
substitutions : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | No correlation between the location of frameshift or nonsense mutations and phenotypic features , including age at diagnosis , the number of tumor foci , and manifestation of nonocular tumors was observed . . | No : O
correlation : O
between : O
the : O
location : O
of : O
frameshift : O
or : O
nonsense : O
mutations : O
and : O
phenotypic : O
features : O
, : O
including : O
age : O
at : O
diagnosis : O
, : O
the : O
number : O
of : O
tumor : B
foci : O
, : O
and : O
manifestation : O
of : O
nonocular : B
tumors : I
was : O
observed : O
. : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | Phenotypic characterization of individuals with 30 - 40 CAG repeats in the Huntington disease ( HD ) gene reveals HD cases with 36 repeats and apparently normal elderly individuals with 36 - 39 repeats . | Phenotypic : O
characterization : O
of : O
individuals : O
with : O
30 : O
- : O
40 : O
CAG : O
repeats : O
in : O
the : O
Huntington : B
disease : I
( : O
HD : B
) : O
gene : O
reveals : O
HD : B
cases : O
with : O
36 : O
repeats : O
and : O
apparently : O
normal : O
elderly : O
individuals : O
with : O
36 : O
- : O
39 : O
repeats : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | Abnormal CAG expansions in the IT - 15 gene are associated with Huntington disease ( HD ) . | Abnormal : O
CAG : O
expansions : O
in : O
the : O
IT : O
- : O
15 : O
gene : O
are : O
associated : O
with : O
Huntington : B
disease : I
( : O
HD : B
) : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | In the diagnostic setting it is necessary to define the limits of the CAG size ranges on normal and HD - associated chromosomes . | In : O
the : O
diagnostic : O
setting : O
it : O
is : O
necessary : O
to : O
define : O
the : O
limits : O
of : O
the : O
CAG : O
size : O
ranges : O
on : O
normal : O
and : O
HD : B
- : O
associated : O
chromosomes : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | Most large analyses that defined the limits of the normal and pathological size ranges employed PCR assays , which included the CAG repeats and a CCG repeat tract that was thought to be invariant . | Most : O
large : O
analyses : O
that : O
defined : O
the : O
limits : O
of : O
the : O
normal : O
and : O
pathological : O
size : O
ranges : O
employed : O
PCR : O
assays : O
, : O
which : O
included : O
the : O
CAG : O
repeats : O
and : O
a : O
CCG : O
repeat : O
tract : O
that : O
was : O
thought : O
to : O
be : O
invariant : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | Many of these experiments found an overlap between the normal and disease size ranges . | Many : O
of : O
these : O
experiments : O
found : O
an : O
overlap : O
between : O
the : O
normal : O
and : O
disease : O
size : O
ranges : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | Subsequent findings that the CCG repeats vary by 8 trinucleotide lengths suggested that the limits of the normal and disease size ranges should be reevaluated with assays that exclude the CCG polymorphism . | Subsequent : O
findings : O
that : O
the : O
CCG : O
repeats : O
vary : O
by : O
8 : O
trinucleotide : O
lengths : O
suggested : O
that : O
the : O
limits : O
of : O
the : O
normal : O
and : O
disease : O
size : O
ranges : O
should : O
be : O
reevaluated : O
with : O
assays : O
that : O
exclude : O
the : O
CCG : O
polymorphism : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | Since patients with between 30 and 40 repeats are rare , a consortium was assembled to collect such individuals . | Since : O
patients : O
with : O
between : O
30 : O
and : O
40 : O
repeats : O
are : O
rare : O
, : O
a : O
consortium : O
was : O
assembled : O
to : O
collect : O
such : O
individuals : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | All 178 samples were reanalyzed in Cambridge by using assays specific for the CAG repeats . | All : O
178 : O
samples : O
were : O
reanalyzed : O
in : O
Cambridge : O
by : O
using : O
assays : O
specific : O
for : O
the : O
CAG : O
repeats : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | We have optimized methods for reliable sizing of CAG repeats and show cases that demonstrate the dangers of using PCR assays that include both the CAG and CCG polymorphisms . | We : O
have : O
optimized : O
methods : O
for : O
reliable : O
sizing : O
of : O
CAG : O
repeats : O
and : O
show : O
cases : O
that : O
demonstrate : O
the : O
dangers : O
of : O
using : O
PCR : O
assays : O
that : O
include : O
both : O
the : O
CAG : O
and : O
CCG : O
polymorphisms : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | Seven HD patients had 36 repeats , which confirms that this allele is associated with disease . | Seven : O
HD : B
patients : O
had : O
36 : O
repeats : O
, : O
which : O
confirms : O
that : O
this : O
allele : O
is : O
associated : O
with : O
disease : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | Individuals without apparent symptoms or signs of HD were found at 36 repeats ( aged 74 , 78 , 79 , and 87 years ) , 37 repeats ( aged 69 years ) , 38 repeats ( aged 69 and 90 years ) , and 39 repeats ( aged 67 , 90 , and 95 years ) . | Individuals : O
without : O
apparent : O
symptoms : O
or : O
signs : O
of : O
HD : B
were : O
found : O
at : O
36 : O
repeats : O
( : O
aged : O
74 : O
, : O
78 : O
, : O
79 : O
, : O
and : O
87 : O
years : O
) : O
, : O
37 : O
repeats : O
( : O
aged : O
69 : O
years : O
) : O
, : O
38 : O
repeats : O
( : O
aged : O
69 : O
and : O
90 : O
years : O
) : O
, : O
and : O
39 : O
repeats : O
( : O
aged : O
67 : O
, : O
90 : O
, : O
and : O
95 : O
years : O
) : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | The detailed case histories of an exceptional case from this series will be presented a 95 - year - old man with 39 repeats who did not have classical features of HD . | The : O
detailed : O
case : O
histories : O
of : O
an : O
exceptional : O
case : O
from : O
this : O
series : O
will : O
be : O
presented : O
a : O
95 : O
- : O
year : O
- : O
old : O
man : O
with : O
39 : O
repeats : O
who : O
did : O
not : O
have : O
classical : O
features : O
of : O
HD : B
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | The apparently healthy survival into old age of some individuals with 36 - 39 repeats suggests that the HD mutation may not always be fully penetrant . . | The : O
apparently : O
healthy : O
survival : O
into : O
old : O
age : O
of : O
some : O
individuals : O
with : O
36 : O
- : O
39 : O
repeats : O
suggests : O
that : O
the : O
HD : B
mutation : O
may : O
not : O
always : O
be : O
fully : O
penetrant : O
. : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | Identification and expression of eight novel mutations among non - Jewish patients with Canavan disease . | Identification : O
and : O
expression : O
of : O
eight : O
novel : O
mutations : O
among : O
non : O
- : O
Jewish : O
patients : O
with : O
Canavan : B
disease : I
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | Canavan disease is inherited as an autosomal recessive trait that is caused by the deficiency of aspartoacylase ( ASPA ) . | Canavan : B
disease : I
is : O
inherited : O
as : O
an : O
autosomal : O
recessive : O
trait : O
that : O
is : O
caused : O
by : O
the : O
deficiency : B
of : I
aspartoacylase : I
( : O
ASPA : O
) : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | The majority of patients with Canavan disease are from an Ashkenazi Jewish background . | The : O
majority : O
of : O
patients : O
with : O
Canavan : B
disease : I
are : O
from : O
an : O
Ashkenazi : O
Jewish : O
background : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | Mutations in ASPA that lead to loss of enzymatic activity have been identified , and E285A and Y231X are the two predominant mutations that account for 97 % of the mutant chromosomes in Ashkenazi Jewish patients . | Mutations : O
in : O
ASPA : O
that : O
lead : O
to : O
loss : O
of : O
enzymatic : O
activity : O
have : O
been : O
identified : O
, : O
and : O
E285A : O
and : O
Y231X : O
are : O
the : O
two : O
predominant : O
mutations : O
that : O
account : O
for : O
97 : O
% : O
of : O
the : O
mutant : O
chromosomes : O
in : O
Ashkenazi : O
Jewish : O
patients : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | The current study was aimed at finding the molecular basis of Canavan disease in 25 independent patients of non - Jewish background . | The : O
current : O
study : O
was : O
aimed : O
at : O
finding : O
the : O
molecular : O
basis : O
of : O
Canavan : B
disease : I
in : O
25 : O
independent : O
patients : O
of : O
non : O
- : O
Jewish : O
background : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | Eight novel and three previously characterized mutations accounted for 80 % ( 40 / 50 ) of mutant chromosomes . | Eight : O
novel : O
and : O
three : O
previously : O
characterized : O
mutations : O
accounted : O
for : O
80 : O
% : O
( : O
40 : O
/ : O
50 : O
) : O
of : O
mutant : O
chromosomes : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | The A305E missense mutation accounted for 48 % ( 24 / 50 ) of mutant chromosomes in patients of western European descent , while the two predominant Jewish mutations each accounted for a single mutant chromosome . | The : O
A305E : O
missense : O
mutation : O
accounted : O
for : O
48 : O
% : O
( : O
24 : O
/ : O
50 : O
) : O
of : O
mutant : O
chromosomes : O
in : O
patients : O
of : O
western : O
European : O
descent : O
, : O
while : O
the : O
two : O
predominant : O
Jewish : O
mutations : O
each : O
accounted : O
for : O
a : O
single : O
mutant : O
chromosome : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | The eight novel mutations identified included 1 - and 4 - bp deletions ( 32 deltaT and 876 deltaAGAA , respectively ) and I16T , G27R , D114E , G123E , C152Y , and R168C missense mutations . | The : O
eight : O
novel : O
mutations : O
identified : O
included : O
1 : O
- : O
and : O
4 : O
- : O
bp : O
deletions : O
( : O
32 : O
deltaT : O
and : O
876 : O
deltaAGAA : O
, : O
respectively : O
) : O
and : O
I16T : O
, : O
G27R : O
, : O
D114E : O
, : O
G123E : O
, : O
C152Y : O
, : O
and : O
R168C : O
missense : O
mutations : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | The homozygous 32 deltaT deletion was identified in the only known patient of African - American origin with Canavan disease . | The : O
homozygous : O
32 : O
deltaT : O
deletion : O
was : O
identified : O
in : O
the : O
only : O
known : O
patient : O
of : O
African : O
- : O
American : O
origin : O
with : O
Canavan : B
disease : I
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | The heterozygosity for 876 deltaAGAA mutation was identified in three independent patients from England . | The : O
heterozygosity : O
for : O
876 : O
deltaAGAA : O
mutation : O
was : O
identified : O
in : O
three : O
independent : O
patients : O
from : O
England : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | Six single - base changes leading to missense mutations were identified in patients from Turkey ( D114E , R168C ) , The Netherlands ( I16T ) , Germany ( G27R ) , Ireland ( C152Y ) , and Canada ( G123E ) . | Six : O
single : O
- : O
base : O
changes : O
leading : O
to : O
missense : O
mutations : O
were : O
identified : O
in : O
patients : O
from : O
Turkey : O
( : O
D114E : O
, : O
R168C : O
) : O
, : O
The : O
Netherlands : O
( : O
I16T : O
) : O
, : O
Germany : O
( : O
G27R : O
) : O
, : O
Ireland : O
( : O
C152Y : O
) : O
, : O
and : O
Canada : O
( : O
G123E : O
) : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | A PCR - based protocol is described that was used to introduce mutations in wild - type cDNA . | A : O
PCR : O
- : O
based : O
protocol : O
is : O
described : O
that : O
was : O
used : O
to : O
introduce : O
mutations : O
in : O
wild : O
- : O
type : O
cDNA : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | In vitro expression of mutant cDNA clones demonstrated that all of these mutations led to a deficiency of ASPA and should therefore result in Canavan disease . . | In : O
vitro : O
expression : O
of : O
mutant : O
cDNA : O
clones : O
demonstrated : O
that : O
all : O
of : O
these : O
mutations : O
led : O
to : O
a : O
deficiency : B
of : I
ASPA : I
and : O
should : O
therefore : O
result : O
in : O
Canavan : B
disease : I
. : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | Identification and chromosomal localization of Atm , the mouse homolog of the ataxia - telangiectasia gene . | Identification : O
and : O
chromosomal : O
localization : O
of : O
Atm : O
, : O
the : O
mouse : O
homolog : O
of : O
the : O
ataxia : B
- : I
telangiectasia : I
gene : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | Atm , the mouse homolog of the human ATM gene defective in ataxia - telangiectasia ( A - T ) , has been identified . | Atm : O
, : O
the : O
mouse : O
homolog : O
of : O
the : O
human : O
ATM : O
gene : O
defective : O
in : O
ataxia : B
- : I
telangiectasia : I
( : O
A : B
- : I
T : I
) : O
, : O
has : O
been : O
identified : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | The entire coding sequence of the Atm transcript was cloned and found to contain an open reading frame encoding a protein of 3066 amino acids with 84 % overall identity and 91 % similarity to the human ATM protein . | The : O
entire : O
coding : O
sequence : O
of : O
the : O
Atm : O
transcript : O
was : O
cloned : O
and : O
found : O
to : O
contain : O
an : O
open : O
reading : O
frame : O
encoding : O
a : O
protein : O
of : O
3066 : O
amino : O
acids : O
with : O
84 : O
% : O
overall : O
identity : O
and : O
91 : O
% : O
similarity : O
to : O
the : O
human : O
ATM : O
protein : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | Variable levels of expression of Atm were observed in different tissues . | Variable : O
levels : O
of : O
expression : O
of : O
Atm : O
were : O
observed : O
in : O
different : O
tissues : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | Fluorescence in situ hybridization and linkage analysis located the Atm gene on mouse chromosome 9 , band 9C , in a region homologous to the ATM region on human chromosome 11q22 - q23 . . | Fluorescence : O
in : O
situ : O
hybridization : O
and : O
linkage : O
analysis : O
located : O
the : O
Atm : O
gene : O
on : O
mouse : O
chromosome : O
9 : O
, : O
band : O
9C : O
, : O
in : O
a : O
region : O
homologous : O
to : O
the : O
ATM : O
region : O
on : O
human : O
chromosome : O
11q22 : O
- : O
q23 : O
. : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | The mouse homolog of the Wiskott - Aldrich syndrome protein ( WASP ) gene is highly conserved and maps near the scurfy ( sf ) mutation on the X chromosome . | The : O
mouse : O
homolog : O
of : O
the : O
Wiskott : B
- : I
Aldrich : I
syndrome : I
protein : O
( : O
WASP : O
) : O
gene : O
is : O
highly : O
conserved : O
and : O
maps : O
near : O
the : O
scurfy : O
( : O
sf : O
) : O
mutation : O
on : O
the : O
X : O
chromosome : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | The mouse WASP gene , the homolog of the gene mutated in Wiskott - Aldrich syndrome , has been isolated and sequenced . the predicted amino acid sequence is 86 % identical to the human WASP sequence . | The : O
mouse : O
WASP : O
gene : O
, : O
the : O
homolog : O
of : O
the : O
gene : O
mutated : O
in : O
Wiskott : B
- : I
Aldrich : I
syndrome : I
, : O
has : O
been : O
isolated : O
and : O
sequenced : O
. : O
the : O
predicted : O
amino : O
acid : O
sequence : O
is : O
86 : O
% : O
identical : O
to : O
the : O
human : O
WASP : O
sequence : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | A distinct feature of the mouse gene is an expanded polymorphic GGA trinucleotide repeat that codes for polyglycine and varies from 15 to 17 triplets in different Mus musculus strains . | A : O
distinct : O
feature : O
of : O
the : O
mouse : O
gene : O
is : O
an : O
expanded : O
polymorphic : O
GGA : O
trinucleotide : O
repeat : O
that : O
codes : O
for : O
polyglycine : O
and : O
varies : O
from : O
15 : O
to : O
17 : O
triplets : O
in : O
different : O
Mus : O
musculus : O
strains : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | The genomic structure of the mouse WASP gene is expressed as an approximately 2 . | The : O
genomic : O
structure : O
of : O
the : O
mouse : O
WASP : O
gene : O
is : O
expressed : O
as : O
an : O
approximately : O
2 : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | 4 - kb mRNA in thymus and spleen . | 4 : O
- : O
kb : O
mRNA : O
in : O
thymus : O
and : O
spleen : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | Chromosomal mapping in an interspecific M . | Chromosomal : O
mapping : O
in : O
an : O
interspecific : O
M : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | Musculus / M . spretus backcross placed the Wasp locus near the centromere of the mouse X chromosome , inseparable from Gata1 , Tcfe3 , and scurfy ( sf ) . | Musculus : O
/ : O
M : O
. : O
spretus : O
backcross : O
placed : O
the : O
Wasp : O
locus : O
near : O
the : O
centromere : O
of : O
the : O
mouse : O
X : O
chromosome : O
, : O
inseparable : O
from : O
Gata1 : O
, : O
Tcfe3 : O
, : O
and : O
scurfy : O
( : O
sf : O
) : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | This localization makes Wasp a candidate for involvement in scurfy , a T cell - mediated fatal lymphoreticular disease of mice that has previously been proposed as a mouse homolog of Wiskott - Aldrich syndrome . | This : O
localization : O
makes : O
Wasp : O
a : O
candidate : O
for : O
involvement : O
in : O
scurfy : O
, : O
a : O
T : O
cell : O
- : O
mediated : O
fatal : B
lymphoreticular : I
disease : I
of : O
mice : O
that : O
has : O
previously : O
been : O
proposed : O
as : O
a : O
mouse : O
homolog : O
of : O
Wiskott : B
- : I
Aldrich : I
syndrome : I
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | Northern analysis of sf tissue samples indicated the presence of WASP mRNA in liver and skin , presumably as a consequence of lymphocytic infiltration , but non abnormalities in the amount or size of mRNA present . | Northern : O
analysis : O
of : O
sf : O
tissue : O
samples : O
indicated : O
the : O
presence : O
of : O
WASP : O
mRNA : O
in : O
liver : O
and : O
skin : O
, : O
presumably : O
as : O
a : O
consequence : O
of : O
lymphocytic : O
infiltration : O
, : O
but : O
non : O
abnormalities : O
in : O
the : O
amount : O
or : O
size : O
of : O
mRNA : O
present : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | Colchicine in breast milk of patients with familial Mediterranean fever . | Colchicine : O
in : O
breast : O
milk : O
of : O
patients : O
with : O
familial : B
Mediterranean : I
fever : I
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | OBJECTIVE . | OBJECTIVE : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | To clarify whether colchicine is excreted in breast milk , and to compare its concentrations in the serum and breast milk of lactating women who have familial Mediterranean fever ( FMF ) . | To : O
clarify : O
whether : O
colchicine : O
is : O
excreted : O
in : O
breast : O
milk : O
, : O
and : O
to : O
compare : O
its : O
concentrations : O
in : O
the : O
serum : O
and : O
breast : O
milk : O
of : O
lactating : O
women : O
who : O
have : O
familial : B
Mediterranean : I
fever : I
( : O
FMF : B
) : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | METHODS . | METHODS : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | Using a specific radioimmunoassay , we determined colchicine concentrations in the serum and breast milk of 4 patients at various time points , following oral administration of the drug . | Using : O
a : O
specific : O
radioimmunoassay : O
, : O
we : O
determined : O
colchicine : O
concentrations : O
in : O
the : O
serum : O
and : O
breast : O
milk : O
of : O
4 : O
patients : O
at : O
various : O
time : O
points : O
, : O
following : O
oral : O
administration : O
of : O
the : O
drug : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | The study evaluated 4 patients with FMF who had been taking colchicine on a long - term basis . | The : O
study : O
evaluated : O
4 : O
patients : O
with : O
FMF : B
who : O
had : O
been : O
taking : O
colchicine : O
on : O
a : O
long : O
- : O
term : O
basis : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | RESULTS . | RESULTS : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | Colchicine was found to be excreted in breast milk . | Colchicine : O
was : O
found : O
to : O
be : O
excreted : O
in : O
breast : O
milk : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | Its levels ranged between 1 . | Its : O
levels : O
ranged : O
between : O
1 : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | 9 and 8 . | 9 : O
and : O
8 : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | 6 ng / ml , which were similar to those found in the serum ( parallel concentration time curves ) . | 6 : O
ng : O
/ : O
ml : O
, : O
which : O
were : O
similar : O
to : O
those : O
found : O
in : O
the : O
serum : O
( : O
parallel : O
concentration : O
time : O
curves : O
) : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | However , there appeared to be a considerable variation in colchicine milk concentration among the different patients , which might be related to individual breast milk composition and , possibly , to other nutritional or metabolic factors . | However : O
, : O
there : O
appeared : O
to : O
be : O
a : O
considerable : O
variation : O
in : O
colchicine : O
milk : O
concentration : O
among : O
the : O
different : O
patients : O
, : O
which : O
might : O
be : O
related : O
to : O
individual : O
breast : O
milk : O
composition : O
and : O
, : O
possibly : O
, : O
to : O
other : O
nutritional : O
or : O
metabolic : O
factors : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | CONCLUSION . | CONCLUSION : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | The extensive peripheral tissue binding and relatively low concentration of colchicine in breast milk suggests that the amount ingested by the infant is small . | The : O
extensive : O
peripheral : O
tissue : O
binding : O
and : O
relatively : O
low : O
concentration : O
of : O
colchicine : O
in : O
breast : O
milk : O
suggests : O
that : O
the : O
amount : O
ingested : O
by : O
the : O
infant : O
is : O
small : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | Furthermore , based on our clinical experience , nursing appears to be safe for lactating women with FMF who continue to take colchicine . | Furthermore : O
, : O
based : O
on : O
our : O
clinical : O
experience : O
, : O
nursing : O
appears : O
to : O
be : O
safe : O
for : O
lactating : O
women : O
with : O
FMF : B
who : O
continue : O
to : O
take : O
colchicine : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | Abnormal myotonic dystrophy protein kinase levels produce only mild myopathy in mice . | Abnormal : O
myotonic : B
dystrophy : I
protein : O
kinase : O
levels : O
produce : O
only : O
mild : O
myopathy : B
in : O
mice : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | Myotonic dystrophy ( DM ) is commonly associated with CTG repeat expansions within the gene for DM - protein kinase ( DMPK ) . | Myotonic : B
dystrophy : I
( : O
DM : B
) : O
is : O
commonly : O
associated : O
with : O
CTG : O
repeat : O
expansions : O
within : O
the : O
gene : O
for : O
DM : O
- : O
protein : O
kinase : O
( : O
DMPK : O
) : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | The effect of altered expression levels of DMPK , which is ubiquitously expressed in all muscle cell lineages during development , was examined by disrupting the endogenous Dmpk gene and overexpressing a normal human DMPK transgene in mice . | The : O
effect : O
of : O
altered : O
expression : O
levels : O
of : O
DMPK : O
, : O
which : O
is : O
ubiquitously : O
expressed : O
in : O
all : O
muscle : O
cell : O
lineages : O
during : O
development : O
, : O
was : O
examined : O
by : O
disrupting : O
the : O
endogenous : O
Dmpk : O
gene : O
and : O
overexpressing : O
a : O
normal : O
human : O
DMPK : O
transgene : O
in : O
mice : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | Nullizygous ( - / - ) mice showed only inconsistent and minor size changes in head and neck muscle fibres at older age , animals with the highest DMPK transgene expression showed hypertrophic cardiomyopathy and enhanced neonatal mortality . | Nullizygous : O
( : O
- : O
/ : O
- : O
) : O
mice : O
showed : O
only : O
inconsistent : O
and : O
minor : O
size : O
changes : O
in : O
head : O
and : O
neck : O
muscle : O
fibres : O
at : O
older : O
age : O
, : O
animals : O
with : O
the : O
highest : O
DMPK : O
transgene : O
expression : O
showed : O
hypertrophic : B
cardiomyopathy : I
and : O
enhanced : O
neonatal : O
mortality : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | However , both models lack other frequent DM symptoms including the fibre - type dependent atrophy , myotonia , cataract and male - infertility . | However : O
, : O
both : O
models : O
lack : O
other : O
frequent : O
DM : B
symptoms : O
including : O
the : O
fibre : O
- : O
type : O
dependent : O
atrophy : B
, : O
myotonia : B
, : O
cataract : B
and : O
male : B
- : I
infertility : I
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | These results strengthen the contention that simple loss - or gain - of - expression of DMPK is not the only crucial requirement for development of the disease . . | These : O
results : O
strengthen : O
the : O
contention : O
that : O
simple : O
loss : O
- : O
or : O
gain : O
- : O
of : O
- : O
expression : O
of : O
DMPK : O
is : O
not : O
the : O
only : O
crucial : O
requirement : O
for : O
development : O
of : O
the : O
disease : O
. : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | Mice lacking the myotonic dystrophy protein kinase develop a late onset progressive myopathy . | Mice : O
lacking : O
the : O
myotonic : B
dystrophy : I
protein : O
kinase : O
develop : O
a : O
late : O
onset : O
progressive : O
myopathy : B
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | Myotonic dystrophy ( DM ) is an autosomal dominant disorder resulting from the expansion of a CTG repeat in the 3 untranslated region of a putative protein kinase ( DMPK ) . | Myotonic : B
dystrophy : I
( : O
DM : B
) : O
is : O
an : O
autosomal : B
dominant : I
disorder : I
resulting : O
from : O
the : O
expansion : O
of : O
a : O
CTG : O
repeat : O
in : O
the : O
3 : O
untranslated : O
region : O
of : O
a : O
putative : O
protein : O
kinase : O
( : O
DMPK : O
) : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | To elucidate the role of DMPK in DM pathogenesis we have developed Dmpk deficient ( Dmpk - / - ) mice . | To : O
elucidate : O
the : O
role : O
of : O
DMPK : O
in : O
DM : B
pathogenesis : O
we : O
have : O
developed : O
Dmpk : B
deficient : I
( : O
Dmpk : O
- : O
/ : O
- : O
) : O
mice : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | Dmpk - / - mice develop a late - onset , progressive skeletal myopathy that shares some pathological features with DM . | Dmpk : O
- : O
/ : O
- : O
mice : O
develop : O
a : O
late : O
- : O
onset : O
, : O
progressive : B
skeletal : I
myopathy : I
that : O
shares : O
some : O
pathological : O
features : O
with : O
DM : B
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | Muscles from mature mice show variation in fibre size , increased fibre degeneration and fibrosis . | Muscles : O
from : O
mature : O
mice : O
show : O
variation : O
in : O
fibre : O
size : O
, : O
increased : O
fibre : B
degeneration : I
and : O
fibrosis : B
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | Adult Dmpk - / - mice show ultrastructural changes in muscle and a 50 % decrease in force generation compared to young mice . | Adult : O
Dmpk : O
- : O
/ : O
- : O
mice : O
show : O
ultrastructural : O
changes : O
in : O
muscle : O
and : O
a : O
50 : O
% : O
decrease : O
in : O
force : O
generation : O
compared : O
to : O
young : O
mice : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | Our results indicate that DMPK may be necessary for the maintenance of skeletal muscle structure and function and suggest that a decrease in DMPK levels may contribute to DM pathology . . | Our : O
results : O
indicate : O
that : O
DMPK : O
may : O
be : O
necessary : O
for : O
the : O
maintenance : O
of : O
skeletal : O
muscle : O
structure : O
and : O
function : O
and : O
suggest : O
that : O
a : O
decrease : O
in : O
DMPK : O
levels : O
may : O
contribute : O
to : O
DM : B
pathology : O
. : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse . | The : O
tumor : B
suppressor : O
gene : O
Brca1 : O
is : O
required : O
for : O
embryonic : O
cellular : O
proliferation : O
in : O
the : O
mouse : O
. : O | NCBI-disease |
Subsets and Splits