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In your role as a medical expert, you are tasked with examining a provided clinical text to identify specific cancer hallmarks. This is a multi-class classification assignment, and you should assign one or more labels from the list below to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
With one exception , all the patients had at least a single recurrences of their primary mixed tumor , but two or more recurrences were the norm before development of metastatic foci .
|
Activating invasion & metastasis (IM)
|
hoc
|
Your responsibility as a medical expert is to review a given clinical text for the presence of specific cancer hallmarks. This is a multi-class classification task, and you should assign one or more labels from the provided list to the text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
The metastases were discovered from six to 52 years following the occurrence of the primary tumor .
|
Activating invasion & metastasis (IM)
|
hoc
|
Your responsibility as a medical expert is to review a given clinical text for the presence of specific cancer hallmarks. This is a multi-class classification task, and you should assign one or more labels from the provided list to the text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
Metastatic deposits were identified in bone , lung , regional lymph nodes , skin , kidney , retroperitoneum , oral cavity , pharynx , calvarium , and central nervous system .
|
Activating invasion & metastasis (IM)
|
hoc
|
In your role as a medical expert, you are tasked with examining a provided clinical text to identify specific cancer hallmarks. This is a multi-class classification assignment, and you should assign one or more labels from the list below to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
The metastases either occurred simultaneously with an episode of recurrent mixed tumor ( n = 5 ) or from 5 to 29 years after a recurrence ( n = 6 ) .
|
Activating invasion & metastasis (IM)
|
hoc
|
Your role as a medical expert involves annotating a provided clinical text to identify the presence of specific cancer-related hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the input text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
The treatment of the primary , recurrent , and metastatic neoplasms was surgical excision .
| null |
hoc
|
Your role as a medical expert involves annotating a provided clinical text to identify the presence of specific cancer-related hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the input text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
Follow-up , ranging from 8 months to 16 years following the diagnosis of MZMT , revealed seven patients to be alive without disease ( 64% ) and two dead of causes unrelated to metastatic disease ( 18% ) .
|
Activating invasion & metastasis (IM)
|
hoc
|
As a medical expert, your task is to analyze a given clinical text and identify specific cancer hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
Two patients ( 18% ) died as a direct result of metastatic tumor at 3 and 2 years after metastasis of their mixed tumors .
|
Activating invasion & metastasis (IM)
|
hoc
|
Your role as a medical expert involves annotating a provided clinical text to identify the presence of specific cancer-related hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the input text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
Flow cytometric analysis revealed a diploid DNA cell population in the primary and/or metastatic tumors in nine cases .
|
Activating invasion & metastasis (IM)
|
hoc
|
In your capacity as a medical expert, your task is to assess a provided clinical text for indications of specific cancer hallmarks. This is a multi-class classification challenge, and you should assign one or more labels from the list below to the text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
Aneuploid DNA cell content was identified in two of the cases .
|
Genome instability & mutation (GI)
|
hoc
|
Your role as a medical expert involves annotating a provided clinical text to identify the presence of specific cancer-related hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the input text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
DNA ploidy levels and cell proliferation rates were compared with those of conventional benign mixed tumors and also with malignant mixed tumors .
|
Genome instability & mutation (GI)
|
hoc
|
In your capacity as a medical expert, your task is to assess a provided clinical text for indications of specific cancer hallmarks. This is a multi-class classification challenge, and you should assign one or more labels from the list below to the text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
Retrospective analysis of histologic parameters ( mitotic rate , cellular pleomorphism , infiltrative growth , vascular or lymphatic invasion ) and flow cytometric analysis failed to identify criteria to predict the development of metastasis in these neoplasms .
|
Activating invasion & metastasis (IM)
|
hoc
|
Your role as a medical expert involves annotating a provided clinical text to identify the presence of specific cancer-related hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the input text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
Depression is the most common psychiatric syndrome in cancer patients and adversely affects anti-cancer immune system and life quality of patients .
| null |
hoc
|
In your capacity as a medical expert, your task is to assess a provided clinical text for indications of specific cancer hallmarks. This is a multi-class classification challenge, and you should assign one or more labels from the list below to the text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
Antidepressant desipramine ( DMI ) is clinically prescribed in the auxiliary treatment of cancer patients .
| null |
hoc
|
In your role as a medical expert, you are tasked with examining a provided clinical text to identify specific cancer hallmarks. This is a multi-class classification assignment, and you should assign one or more labels from the list below to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
Increasing evidences suggest that DMI has a broad spectrum of target-off biological effects , such as anticancer properties .
| null |
hoc
|
In your capacity as a medical expert, your task is to assess a provided clinical text for indications of specific cancer hallmarks. This is a multi-class classification challenge, and you should assign one or more labels from the list below to the text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
Our previous study revealed that DMI at the clinical relevant concentrations could induce CHOP-dependent apoptotic death in C6 glioma cells .
| null |
hoc
|
Your role as a medical expert involves annotating a provided clinical text to identify the presence of specific cancer-related hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the input text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
In this study , we further explored the pro-autophagic effect of DMI in C6 glioma cells and its underlying mechanism .
| null |
hoc
|
In your capacity as a medical expert, your task is to assess a provided clinical text for indications of specific cancer hallmarks. This is a multi-class classification challenge, and you should assign one or more labels from the list below to the text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
Treatment with DMI could induce autophagic cell death characterized by the formation of autophagosome and the elevated level of autophagic protein Beclin-1 and cellular redistribution of marker LC3 .
|
Resisting cell death (CD)
|
hoc
|
As a medical expert, your task is to analyze a given clinical text and identify specific cancer hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
Meanwhile , DMI inhibited the activation of PI3K-AKT-mTOR pathway which is considered as a negative regulator of autophagy .
|
Resisting cell death (CD)
|
hoc
|
In your role as a medical expert, you are tasked with examining a provided clinical text to identify specific cancer hallmarks. This is a multi-class classification assignment, and you should assign one or more labels from the list below to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
Furthermore , DMI activated PERK-eIF2α and ATF6 of endoplasmic reticulum ( ER ) stress pathway , while knockdown of PERK with the PERK-specific short interfering RNA ( siRNA ) could obviously attenuate the autophagy .
|
Resisting cell death (CD)
|
hoc
|
As a medical expert, your task is to analyze a given clinical text and identify specific cancer hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
The results strongly suggested that DMI could induce autophagy through the PERK-ER stress pathway in C6 glioma cells .
|
Resisting cell death (CD)
|
hoc
|
Your role as a medical expert involves annotating a provided clinical text to identify the presence of specific cancer-related hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the input text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
Our findings provided new insights into another beneficial potential of antidepressant DMI in the adjuvant therapy of cancer .
| null |
hoc
|
In your role as a medical expert, you are tasked with examining a provided clinical text to identify specific cancer hallmarks. This is a multi-class classification assignment, and you should assign one or more labels from the list below to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
BACKGROUND & AIMS Hepatocytes are considered an exception of the paradigmatic inverse correlation between cell proliferation and terminal differentiation .
| null |
hoc
|
As a medical expert, your task is to analyze a given clinical text and identify specific cancer hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
In fact , hepatic vital functions are guaranteed by proliferating parenchymal cells during liver regeneration .
| null |
hoc
|
In your capacity as a medical expert, your task is to assess a provided clinical text for indications of specific cancer hallmarks. This is a multi-class classification challenge, and you should assign one or more labels from the list below to the text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
However , a fine molecular characterization of the relationship between proliferation and differentiation in hepatocytes has been hampered by the lack of reliable in vivo or in vitro models .
| null |
hoc
|
In your capacity as a medical expert, your task is to assess a provided clinical text for indications of specific cancer hallmarks. This is a multi-class classification challenge, and you should assign one or more labels from the list below to the text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
METHODS The hepatocyte terminal differentiation program was characterized in the immortalized , untransformed and differentiated hepatocytic cell line MMH , using several techniques .
| null |
hoc
|
In your capacity as a medical expert, your task is to assess a provided clinical text for indications of specific cancer hallmarks. This is a multi-class classification challenge, and you should assign one or more labels from the list below to the text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
Particularly , two-dimensional difference gel electrophoresis combined to tandem mass spectrometry proteomic approach was used .
| null |
hoc
|
In your capacity as a medical expert, your task is to assess a provided clinical text for indications of specific cancer hallmarks. This is a multi-class classification challenge, and you should assign one or more labels from the list below to the text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
Cell cycle and cell adhesion properties of MMH have been altered using either myc-overexpression and MEK1/2 inhibition or a constitutive active beta-catenin mutant , respectively .
| null |
hoc
|
Your responsibility as a medical expert is to review a given clinical text for the presence of specific cancer hallmarks. This is a multi-class classification task, and you should assign one or more labels from the provided list to the text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
RESULTS The hepatocyte terminal differentiation program is stimulated by the exit from the cell cycle induced by cell-cell contact .
| null |
hoc
|
Your responsibility as a medical expert is to review a given clinical text for the presence of specific cancer hallmarks. This is a multi-class classification task, and you should assign one or more labels from the provided list to the text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
Comparative proteomic analysis of proliferating versus quiescent hepatocytes validated the importance of contact inhibition , identifying 68 differently expressed gene products , representing 49 unique proteins .
|
Evading growth suppressors (GS)
|
hoc
|
In your role as a medical expert, you are tasked with examining a provided clinical text to identify specific cancer hallmarks. This is a multi-class classification assignment, and you should assign one or more labels from the list below to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
Notably , enzymes involved in important liver functions such as detoxification processes , lipid metabolism , iron and vitamin A storage and secretion , anti-inflammatory response and exocytosis were found significantly up-regulated in quiescent hepatocytes .
| null |
hoc
|
In your role as a medical expert, you are tasked with examining a provided clinical text to identify specific cancer hallmarks. This is a multi-class classification assignment, and you should assign one or more labels from the list below to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
Finally , we found that : ( i ) cell cycle arrest induced by MEK1/2 inhibition is not sufficient to induce hepatic product expression ; ( ii ) constitutive activation of beta-catenin counteracts the contact inhibition-induced terminal differentiation .
|
Evading growth suppressors (GS)
|
hoc
|
In your capacity as a medical expert, your task is to assess a provided clinical text for indications of specific cancer hallmarks. This is a multi-class classification challenge, and you should assign one or more labels from the list below to the text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
CONCLUSION The hepatocyte terminal differentiation program requires a quiescent state maintained by cell-cell contact through the E-cadherin/beta-catenin pathway , rather than the inhibition of proliferation .
| null |
hoc
|
In your role as a medical expert, you are tasked with examining a provided clinical text to identify specific cancer hallmarks. This is a multi-class classification assignment, and you should assign one or more labels from the list below to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
PURPOSE Steroid hormones and growth factors affect lung cancer , and it is possible they act in concert to influence patient outcome .
| null |
hoc
|
As a medical expert, your task is to analyze a given clinical text and identify specific cancer hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
EXPERIMENTAL DESIGN Primary lung tumors and normal lung tissue were analyzed for expression and localization of estrogen receptor α and β-1 ( ERα and ERβ ) , aromatase , progesterone receptor ( PR ) , and epidermal growth factor receptor ( EGFR ) .
| null |
hoc
|
Your responsibility as a medical expert is to review a given clinical text for the presence of specific cancer hallmarks. This is a multi-class classification task, and you should assign one or more labels from the provided list to the text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
RESULTS Tumors expressed higher levels of ERβ compared to matched normal lung , whereas the reverse was true of PR .
|
Sustaining proliferative signaling (PS)
|
hoc
|
Your role as a medical expert involves annotating a provided clinical text to identify the presence of specific cancer-related hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the input text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
High cytoplasmic ERβ expression was identified as an independent negative prognostic predictor of overall survival ( OS ; HR = 1.67 ) , and low total PR was identified as an independent negative predictor of time to progression ( TTP ; HR = 1.59 ) .
|
Sustaining proliferative signaling (PS)
|
hoc
|
In your role as a medical expert, you are tasked with examining a provided clinical text to identify specific cancer hallmarks. This is a multi-class classification assignment, and you should assign one or more labels from the list below to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
After adjusting for stage , age , sex , and smoking , combined high cytoplasmic ERβ and low total PR showed enhanced effects on OS ( HR = 2.64 ) and on TTP ( HR = 6.02 ) .
| null |
hoc
|
In your capacity as a medical expert, your task is to assess a provided clinical text for indications of specific cancer hallmarks. This is a multi-class classification challenge, and you should assign one or more labels from the list below to the text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
Further effects on OS were observed when EGFR expression was included ( HR = 5.32 ) .
|
Sustaining proliferative signaling (PS)
|
hoc
|
As a medical expert, your task is to analyze a given clinical text and identify specific cancer hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
Patients with low cytoplasmic ERβ , low aromatase , low EGFR , and high total PR had shorter OS than patients with the opposite pattern ( HR = 6.60 ) .
|
Sustaining proliferative signaling (PS)
|
hoc
|
Your responsibility as a medical expert is to review a given clinical text for the presence of specific cancer hallmarks. This is a multi-class classification task, and you should assign one or more labels from the provided list to the text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
Contribution of these markers to survival showed no significant sex differences in a multivariable model .
|
Sustaining proliferative signaling (PS)
|
hoc
|
As a medical expert, your task is to analyze a given clinical text and identify specific cancer hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
ERα was elevated in tumors but was not predictive of survival , and appears to represent a variant ERα protein that is only recognized by a C-terminal antibody .
|
Sustaining proliferative signaling (PS)
|
hoc
|
Your role as a medical expert involves annotating a provided clinical text to identify the presence of specific cancer-related hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the input text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
CONCLUSIONS Hormonal and EGFR pathways together may contribute to lung cancer prognosis .
|
Sustaining proliferative signaling (PS)
|
hoc
|
As a medical expert, your task is to analyze a given clinical text and identify specific cancer hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
Lung tumors with high ERβ-1/low PR may define patients with aggressive biology .
|
Sustaining proliferative signaling (PS)
|
hoc
|
Your responsibility as a medical expert is to review a given clinical text for the presence of specific cancer hallmarks. This is a multi-class classification task, and you should assign one or more labels from the provided list to the text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
A validation study is necessary to fully assess the predictive value of these markers .
| null |
hoc
|
As a medical expert, your task is to analyze a given clinical text and identify specific cancer hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
Glutathione S-transferase ( GST ) class Mu activity was determined in 145 unrelated hospital patients in Berlin by measuring their conjugation activity towards the specific substrate trans-stilbene oxide ( TSO ) with two substrate concentrations ( 50 and 250 microM ) in homogenates prepared from lymphocytes .
| null |
hoc
|
In your role as a medical expert, you are tasked with examining a provided clinical text to identify specific cancer hallmarks. This is a multi-class classification assignment, and you should assign one or more labels from the list below to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
Eighty individuals ( 55.2% ) had an activity lower than 10 pmol/min/10(6) lymphocytes and were classified as GST class Mu deficient .
| null |
hoc
|
In your role as a medical expert, you are tasked with examining a provided clinical text to identify specific cancer hallmarks. This is a multi-class classification assignment, and you should assign one or more labels from the list below to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
In 142 of 145 cases , phenotype was confirmed by the results of a genotyping procedure using the polymerase chain reaction technique .
| null |
hoc
|
In your capacity as a medical expert, your task is to assess a provided clinical text for indications of specific cancer hallmarks. This is a multi-class classification challenge, and you should assign one or more labels from the list below to the text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
Two fragments of 273 and about 650 bp including one and two introns , respectively , could always be amplified from genomic DNA in individuals with high GST class Mu activity and could not be amplified in persons with impaired glutathione-TSO conjugation activity .
| null |
hoc
|
As a medical expert, your task is to analyze a given clinical text and identify specific cancer hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
This indicates that persons with low activity carry a large deletion mutation within the GST class Mu gene .
|
Genome instability & mutation (GI)
|
hoc
|
Your responsibility as a medical expert is to review a given clinical text for the presence of specific cancer hallmarks. This is a multi-class classification task, and you should assign one or more labels from the provided list to the text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
The enzymatically determined antimode between low and high activity determined as 10 pmol/min/1 million lymphocytes in the assay with 50 microM TSO could be clearly confirmed by genotyping .
| null |
hoc
|
As a medical expert, your task is to analyze a given clinical text and identify specific cancer hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
To investigate whether the Bcl-2 gene family is involved in modulating mechanism of apoptosis and change of cell cycle protein induced by curcumin in acute myeloid leukemia HL-60 cell line and primary acute myelogenous leukemic cells , the Bcl-2 family member Mcl-1 , Bax and Bak and cell cycle proteins including P27kipl , P21wafl , cyclin D3 and pRbp- were selected and their expression detected by SABC immuno-histochemical stain method .
| null |
hoc
|
Your responsibility as a medical expert is to review a given clinical text for the presence of specific cancer hallmarks. This is a multi-class classification task, and you should assign one or more labels from the provided list to the text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
The attitude of sub-G1 peak in DNA histogram was determined by FCM .
| null |
hoc
|
In your role as a medical expert, you are tasked with examining a provided clinical text to identify specific cancer hallmarks. This is a multi-class classification assignment, and you should assign one or more labels from the list below to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
The TUNEL positive cell percentage was identified by terminal deoxynucleotidyl transferase ( TdT)-mediated Biotin dUNP end labeling technique .
| null |
hoc
|
As a medical expert, your task is to analyze a given clinical text and identify specific cancer hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
It was found that when HL-60 cells were treated with 25 mumol/L curcumin for 24 h , the expression level of Mcl-1 was down-regulated , but that of Bax and Bak up-regulated time-dependently .
| null |
hoc
|
As a medical expert, your task is to analyze a given clinical text and identify specific cancer hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
There was significant difference in the expression level of Mcl-1 , Bax and Bak between the curcumin-treated groups and control group ( P < 0.05-0.01 ) .
| null |
hoc
|
Your role as a medical expert involves annotating a provided clinical text to identify the presence of specific cancer-related hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the input text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
At the same time , curcumin had no effect on progress of cell cycle in primaty acute myelogenous leukemia at newly diagnosis , but could increase the peak of Sub-G1 ( P < 0.05 ) , and down-regulate the expression of Mcl-1 and up-regulate the expression of Bax and Bak with the difference being statistically significant .
|
Sustaining proliferative signaling (PS)
|
hoc
|
Your responsibility as a medical expert is to review a given clinical text for the presence of specific cancer hallmarks. This is a multi-class classification task, and you should assign one or more labels from the provided list to the text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
The expression of P27kipl , P21wafl and pRbp- were elevated and that of cyclin D3 decreased in the presence of curcumin .
|
Sustaining proliferative signaling (PS), Evading growth suppressors (GS)
|
hoc
|
Your role as a medical expert involves annotating a provided clinical text to identify the presence of specific cancer-related hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the input text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
These findings suggested that the Bcl-2 gene family indeed participated in the regulatory process of apoptosis induced by curcumin in HL-60 cells and AML cells .
|
Resisting cell death (CD)
|
hoc
|
As a medical expert, your task is to analyze a given clinical text and identify specific cancer hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
Curcumin can induce apoptosis of primary acute myelogenous leukemic cells and disturb cell cycle progression of HL-60 cells .
|
Sustaining proliferative signaling (PS), Resisting cell death (CD)
|
hoc
|
In your capacity as a medical expert, your task is to assess a provided clinical text for indications of specific cancer hallmarks. This is a multi-class classification challenge, and you should assign one or more labels from the list below to the text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
The mechanism appeared to be mediated by perturbing G0/G1 phases checkpoints which associated with up-regulation of P27kipl , P21wafl and pRbp- expression , and down-regulation of cyclin D3 .
|
Sustaining proliferative signaling (PS), Evading growth suppressors (GS)
|
hoc
|
In your capacity as a medical expert, your task is to assess a provided clinical text for indications of specific cancer hallmarks. This is a multi-class classification challenge, and you should assign one or more labels from the list below to the text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
The colon carcinoma cell line CC531 is metastatic to liver after splenic injection in syngeneic rats .
|
Activating invasion & metastasis (IM)
|
hoc
|
As a medical expert, your task is to analyze a given clinical text and identify specific cancer hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
After repeated in vivo passages , a subline was selected that produced liver metastases at a considerably higher rate than the original cell line .
|
Activating invasion & metastasis (IM)
|
hoc
|
In your role as a medical expert, you are tasked with examining a provided clinical text to identify specific cancer hallmarks. This is a multi-class classification assignment, and you should assign one or more labels from the list below to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
These cells were characterized by increased intracellular glutathione , proliferation and ability to restore glutathione after exposure to oxidative stress , thus indicating an elevated resistance to oxidative stress .
|
Tumor-promoting inflammation (TPI)
|
hoc
|
As a medical expert, your task is to analyze a given clinical text and identify specific cancer hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
Furthermore , the increased metastatic ability was also accompanied by increased proliferation rate , adhesion to extracellular matrix proteins and endothelial cells , and secretion of a 60 kD matrix metalloproteinase .
|
Activating invasion & metastasis (IM)
|
hoc
|
As a medical expert, your task is to analyze a given clinical text and identify specific cancer hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
When cultured in vitro for a prolonged time ( more than 30 trypsinizations ) , the cells showed a reduced in vivo metastatic ability , reduced secretion of three metalloproteinases including the 60 kD proteinase , and reduced intracellular glutathione .
|
Activating invasion & metastasis (IM)
|
hoc
|
In your role as a medical expert, you are tasked with examining a provided clinical text to identify specific cancer hallmarks. This is a multi-class classification assignment, and you should assign one or more labels from the list below to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None
|
These results indicate that metastatic ability can be influenced through several adaptive mechanisms , and that the cell's ability to resist oxidative stress and maintain intracellular glutathione are of central importance .
|
Activating invasion & metastasis (IM), Tumor-promoting inflammation (TPI)
|
hoc
|
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