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In your role as a medical expert, you are tasked with examining a provided clinical text to identify specific cancer hallmarks. This is a multi-class classification assignment, and you should assign one or more labels from the list below to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | With one exception , all the patients had at least a single recurrences of their primary mixed tumor , but two or more recurrences were the norm before development of metastatic foci . | Activating invasion & metastasis (IM) | hoc |
Your responsibility as a medical expert is to review a given clinical text for the presence of specific cancer hallmarks. This is a multi-class classification task, and you should assign one or more labels from the provided list to the text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | The metastases were discovered from six to 52 years following the occurrence of the primary tumor . | Activating invasion & metastasis (IM) | hoc |
Your responsibility as a medical expert is to review a given clinical text for the presence of specific cancer hallmarks. This is a multi-class classification task, and you should assign one or more labels from the provided list to the text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | Metastatic deposits were identified in bone , lung , regional lymph nodes , skin , kidney , retroperitoneum , oral cavity , pharynx , calvarium , and central nervous system . | Activating invasion & metastasis (IM) | hoc |
In your role as a medical expert, you are tasked with examining a provided clinical text to identify specific cancer hallmarks. This is a multi-class classification assignment, and you should assign one or more labels from the list below to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | The metastases either occurred simultaneously with an episode of recurrent mixed tumor ( n = 5 ) or from 5 to 29 years after a recurrence ( n = 6 ) . | Activating invasion & metastasis (IM) | hoc |
Your role as a medical expert involves annotating a provided clinical text to identify the presence of specific cancer-related hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the input text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | The treatment of the primary , recurrent , and metastatic neoplasms was surgical excision . | null | hoc |
Your role as a medical expert involves annotating a provided clinical text to identify the presence of specific cancer-related hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the input text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | Follow-up , ranging from 8 months to 16 years following the diagnosis of MZMT , revealed seven patients to be alive without disease ( 64% ) and two dead of causes unrelated to metastatic disease ( 18% ) . | Activating invasion & metastasis (IM) | hoc |
As a medical expert, your task is to analyze a given clinical text and identify specific cancer hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | Two patients ( 18% ) died as a direct result of metastatic tumor at 3 and 2 years after metastasis of their mixed tumors . | Activating invasion & metastasis (IM) | hoc |
Your role as a medical expert involves annotating a provided clinical text to identify the presence of specific cancer-related hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the input text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | Flow cytometric analysis revealed a diploid DNA cell population in the primary and/or metastatic tumors in nine cases . | Activating invasion & metastasis (IM) | hoc |
In your capacity as a medical expert, your task is to assess a provided clinical text for indications of specific cancer hallmarks. This is a multi-class classification challenge, and you should assign one or more labels from the list below to the text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | Aneuploid DNA cell content was identified in two of the cases . | Genome instability & mutation (GI) | hoc |
Your role as a medical expert involves annotating a provided clinical text to identify the presence of specific cancer-related hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the input text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | DNA ploidy levels and cell proliferation rates were compared with those of conventional benign mixed tumors and also with malignant mixed tumors . | Genome instability & mutation (GI) | hoc |
In your capacity as a medical expert, your task is to assess a provided clinical text for indications of specific cancer hallmarks. This is a multi-class classification challenge, and you should assign one or more labels from the list below to the text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | Retrospective analysis of histologic parameters ( mitotic rate , cellular pleomorphism , infiltrative growth , vascular or lymphatic invasion ) and flow cytometric analysis failed to identify criteria to predict the development of metastasis in these neoplasms . | Activating invasion & metastasis (IM) | hoc |
Your role as a medical expert involves annotating a provided clinical text to identify the presence of specific cancer-related hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the input text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | Depression is the most common psychiatric syndrome in cancer patients and adversely affects anti-cancer immune system and life quality of patients . | null | hoc |
In your capacity as a medical expert, your task is to assess a provided clinical text for indications of specific cancer hallmarks. This is a multi-class classification challenge, and you should assign one or more labels from the list below to the text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | Antidepressant desipramine ( DMI ) is clinically prescribed in the auxiliary treatment of cancer patients . | null | hoc |
In your role as a medical expert, you are tasked with examining a provided clinical text to identify specific cancer hallmarks. This is a multi-class classification assignment, and you should assign one or more labels from the list below to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | Increasing evidences suggest that DMI has a broad spectrum of target-off biological effects , such as anticancer properties . | null | hoc |
In your capacity as a medical expert, your task is to assess a provided clinical text for indications of specific cancer hallmarks. This is a multi-class classification challenge, and you should assign one or more labels from the list below to the text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | Our previous study revealed that DMI at the clinical relevant concentrations could induce CHOP-dependent apoptotic death in C6 glioma cells . | null | hoc |
Your role as a medical expert involves annotating a provided clinical text to identify the presence of specific cancer-related hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the input text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | In this study , we further explored the pro-autophagic effect of DMI in C6 glioma cells and its underlying mechanism . | null | hoc |
In your capacity as a medical expert, your task is to assess a provided clinical text for indications of specific cancer hallmarks. This is a multi-class classification challenge, and you should assign one or more labels from the list below to the text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | Treatment with DMI could induce autophagic cell death characterized by the formation of autophagosome and the elevated level of autophagic protein Beclin-1 and cellular redistribution of marker LC3 . | Resisting cell death (CD) | hoc |
As a medical expert, your task is to analyze a given clinical text and identify specific cancer hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | Meanwhile , DMI inhibited the activation of PI3K-AKT-mTOR pathway which is considered as a negative regulator of autophagy . | Resisting cell death (CD) | hoc |
In your role as a medical expert, you are tasked with examining a provided clinical text to identify specific cancer hallmarks. This is a multi-class classification assignment, and you should assign one or more labels from the list below to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | Furthermore , DMI activated PERK-eIF2α and ATF6 of endoplasmic reticulum ( ER ) stress pathway , while knockdown of PERK with the PERK-specific short interfering RNA ( siRNA ) could obviously attenuate the autophagy . | Resisting cell death (CD) | hoc |
As a medical expert, your task is to analyze a given clinical text and identify specific cancer hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | The results strongly suggested that DMI could induce autophagy through the PERK-ER stress pathway in C6 glioma cells . | Resisting cell death (CD) | hoc |
Your role as a medical expert involves annotating a provided clinical text to identify the presence of specific cancer-related hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the input text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | Our findings provided new insights into another beneficial potential of antidepressant DMI in the adjuvant therapy of cancer . | null | hoc |
In your role as a medical expert, you are tasked with examining a provided clinical text to identify specific cancer hallmarks. This is a multi-class classification assignment, and you should assign one or more labels from the list below to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | BACKGROUND & AIMS Hepatocytes are considered an exception of the paradigmatic inverse correlation between cell proliferation and terminal differentiation . | null | hoc |
As a medical expert, your task is to analyze a given clinical text and identify specific cancer hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | In fact , hepatic vital functions are guaranteed by proliferating parenchymal cells during liver regeneration . | null | hoc |
In your capacity as a medical expert, your task is to assess a provided clinical text for indications of specific cancer hallmarks. This is a multi-class classification challenge, and you should assign one or more labels from the list below to the text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | However , a fine molecular characterization of the relationship between proliferation and differentiation in hepatocytes has been hampered by the lack of reliable in vivo or in vitro models . | null | hoc |
In your capacity as a medical expert, your task is to assess a provided clinical text for indications of specific cancer hallmarks. This is a multi-class classification challenge, and you should assign one or more labels from the list below to the text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | METHODS The hepatocyte terminal differentiation program was characterized in the immortalized , untransformed and differentiated hepatocytic cell line MMH , using several techniques . | null | hoc |
In your capacity as a medical expert, your task is to assess a provided clinical text for indications of specific cancer hallmarks. This is a multi-class classification challenge, and you should assign one or more labels from the list below to the text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | Particularly , two-dimensional difference gel electrophoresis combined to tandem mass spectrometry proteomic approach was used . | null | hoc |
In your capacity as a medical expert, your task is to assess a provided clinical text for indications of specific cancer hallmarks. This is a multi-class classification challenge, and you should assign one or more labels from the list below to the text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | Cell cycle and cell adhesion properties of MMH have been altered using either myc-overexpression and MEK1/2 inhibition or a constitutive active beta-catenin mutant , respectively . | null | hoc |
Your responsibility as a medical expert is to review a given clinical text for the presence of specific cancer hallmarks. This is a multi-class classification task, and you should assign one or more labels from the provided list to the text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | RESULTS The hepatocyte terminal differentiation program is stimulated by the exit from the cell cycle induced by cell-cell contact . | null | hoc |
Your responsibility as a medical expert is to review a given clinical text for the presence of specific cancer hallmarks. This is a multi-class classification task, and you should assign one or more labels from the provided list to the text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | Comparative proteomic analysis of proliferating versus quiescent hepatocytes validated the importance of contact inhibition , identifying 68 differently expressed gene products , representing 49 unique proteins . | Evading growth suppressors (GS) | hoc |
In your role as a medical expert, you are tasked with examining a provided clinical text to identify specific cancer hallmarks. This is a multi-class classification assignment, and you should assign one or more labels from the list below to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | Notably , enzymes involved in important liver functions such as detoxification processes , lipid metabolism , iron and vitamin A storage and secretion , anti-inflammatory response and exocytosis were found significantly up-regulated in quiescent hepatocytes . | null | hoc |
In your role as a medical expert, you are tasked with examining a provided clinical text to identify specific cancer hallmarks. This is a multi-class classification assignment, and you should assign one or more labels from the list below to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | Finally , we found that : ( i ) cell cycle arrest induced by MEK1/2 inhibition is not sufficient to induce hepatic product expression ; ( ii ) constitutive activation of beta-catenin counteracts the contact inhibition-induced terminal differentiation . | Evading growth suppressors (GS) | hoc |
In your capacity as a medical expert, your task is to assess a provided clinical text for indications of specific cancer hallmarks. This is a multi-class classification challenge, and you should assign one or more labels from the list below to the text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | CONCLUSION The hepatocyte terminal differentiation program requires a quiescent state maintained by cell-cell contact through the E-cadherin/beta-catenin pathway , rather than the inhibition of proliferation . | null | hoc |
In your role as a medical expert, you are tasked with examining a provided clinical text to identify specific cancer hallmarks. This is a multi-class classification assignment, and you should assign one or more labels from the list below to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | PURPOSE Steroid hormones and growth factors affect lung cancer , and it is possible they act in concert to influence patient outcome . | null | hoc |
As a medical expert, your task is to analyze a given clinical text and identify specific cancer hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | EXPERIMENTAL DESIGN Primary lung tumors and normal lung tissue were analyzed for expression and localization of estrogen receptor α and β-1 ( ERα and ERβ ) , aromatase , progesterone receptor ( PR ) , and epidermal growth factor receptor ( EGFR ) . | null | hoc |
Your responsibility as a medical expert is to review a given clinical text for the presence of specific cancer hallmarks. This is a multi-class classification task, and you should assign one or more labels from the provided list to the text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | RESULTS Tumors expressed higher levels of ERβ compared to matched normal lung , whereas the reverse was true of PR . | Sustaining proliferative signaling (PS) | hoc |
Your role as a medical expert involves annotating a provided clinical text to identify the presence of specific cancer-related hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the input text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | High cytoplasmic ERβ expression was identified as an independent negative prognostic predictor of overall survival ( OS ; HR = 1.67 ) , and low total PR was identified as an independent negative predictor of time to progression ( TTP ; HR = 1.59 ) . | Sustaining proliferative signaling (PS) | hoc |
In your role as a medical expert, you are tasked with examining a provided clinical text to identify specific cancer hallmarks. This is a multi-class classification assignment, and you should assign one or more labels from the list below to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | After adjusting for stage , age , sex , and smoking , combined high cytoplasmic ERβ and low total PR showed enhanced effects on OS ( HR = 2.64 ) and on TTP ( HR = 6.02 ) . | null | hoc |
In your capacity as a medical expert, your task is to assess a provided clinical text for indications of specific cancer hallmarks. This is a multi-class classification challenge, and you should assign one or more labels from the list below to the text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | Further effects on OS were observed when EGFR expression was included ( HR = 5.32 ) . | Sustaining proliferative signaling (PS) | hoc |
As a medical expert, your task is to analyze a given clinical text and identify specific cancer hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | Patients with low cytoplasmic ERβ , low aromatase , low EGFR , and high total PR had shorter OS than patients with the opposite pattern ( HR = 6.60 ) . | Sustaining proliferative signaling (PS) | hoc |
Your responsibility as a medical expert is to review a given clinical text for the presence of specific cancer hallmarks. This is a multi-class classification task, and you should assign one or more labels from the provided list to the text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | Contribution of these markers to survival showed no significant sex differences in a multivariable model . | Sustaining proliferative signaling (PS) | hoc |
As a medical expert, your task is to analyze a given clinical text and identify specific cancer hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | ERα was elevated in tumors but was not predictive of survival , and appears to represent a variant ERα protein that is only recognized by a C-terminal antibody . | Sustaining proliferative signaling (PS) | hoc |
Your role as a medical expert involves annotating a provided clinical text to identify the presence of specific cancer-related hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the input text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | CONCLUSIONS Hormonal and EGFR pathways together may contribute to lung cancer prognosis . | Sustaining proliferative signaling (PS) | hoc |
As a medical expert, your task is to analyze a given clinical text and identify specific cancer hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | Lung tumors with high ERβ-1/low PR may define patients with aggressive biology . | Sustaining proliferative signaling (PS) | hoc |
Your responsibility as a medical expert is to review a given clinical text for the presence of specific cancer hallmarks. This is a multi-class classification task, and you should assign one or more labels from the provided list to the text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | A validation study is necessary to fully assess the predictive value of these markers . | null | hoc |
As a medical expert, your task is to analyze a given clinical text and identify specific cancer hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | Glutathione S-transferase ( GST ) class Mu activity was determined in 145 unrelated hospital patients in Berlin by measuring their conjugation activity towards the specific substrate trans-stilbene oxide ( TSO ) with two substrate concentrations ( 50 and 250 microM ) in homogenates prepared from lymphocytes . | null | hoc |
In your role as a medical expert, you are tasked with examining a provided clinical text to identify specific cancer hallmarks. This is a multi-class classification assignment, and you should assign one or more labels from the list below to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | Eighty individuals ( 55.2% ) had an activity lower than 10 pmol/min/10(6) lymphocytes and were classified as GST class Mu deficient . | null | hoc |
In your role as a medical expert, you are tasked with examining a provided clinical text to identify specific cancer hallmarks. This is a multi-class classification assignment, and you should assign one or more labels from the list below to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | In 142 of 145 cases , phenotype was confirmed by the results of a genotyping procedure using the polymerase chain reaction technique . | null | hoc |
In your capacity as a medical expert, your task is to assess a provided clinical text for indications of specific cancer hallmarks. This is a multi-class classification challenge, and you should assign one or more labels from the list below to the text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | Two fragments of 273 and about 650 bp including one and two introns , respectively , could always be amplified from genomic DNA in individuals with high GST class Mu activity and could not be amplified in persons with impaired glutathione-TSO conjugation activity . | null | hoc |
As a medical expert, your task is to analyze a given clinical text and identify specific cancer hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | This indicates that persons with low activity carry a large deletion mutation within the GST class Mu gene . | Genome instability & mutation (GI) | hoc |
Your responsibility as a medical expert is to review a given clinical text for the presence of specific cancer hallmarks. This is a multi-class classification task, and you should assign one or more labels from the provided list to the text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | The enzymatically determined antimode between low and high activity determined as 10 pmol/min/1 million lymphocytes in the assay with 50 microM TSO could be clearly confirmed by genotyping . | null | hoc |
As a medical expert, your task is to analyze a given clinical text and identify specific cancer hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | To investigate whether the Bcl-2 gene family is involved in modulating mechanism of apoptosis and change of cell cycle protein induced by curcumin in acute myeloid leukemia HL-60 cell line and primary acute myelogenous leukemic cells , the Bcl-2 family member Mcl-1 , Bax and Bak and cell cycle proteins including P27kipl , P21wafl , cyclin D3 and pRbp- were selected and their expression detected by SABC immuno-histochemical stain method . | null | hoc |
Your responsibility as a medical expert is to review a given clinical text for the presence of specific cancer hallmarks. This is a multi-class classification task, and you should assign one or more labels from the provided list to the text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | The attitude of sub-G1 peak in DNA histogram was determined by FCM . | null | hoc |
In your role as a medical expert, you are tasked with examining a provided clinical text to identify specific cancer hallmarks. This is a multi-class classification assignment, and you should assign one or more labels from the list below to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | The TUNEL positive cell percentage was identified by terminal deoxynucleotidyl transferase ( TdT)-mediated Biotin dUNP end labeling technique . | null | hoc |
As a medical expert, your task is to analyze a given clinical text and identify specific cancer hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | It was found that when HL-60 cells were treated with 25 mumol/L curcumin for 24 h , the expression level of Mcl-1 was down-regulated , but that of Bax and Bak up-regulated time-dependently . | null | hoc |
As a medical expert, your task is to analyze a given clinical text and identify specific cancer hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | There was significant difference in the expression level of Mcl-1 , Bax and Bak between the curcumin-treated groups and control group ( P < 0.05-0.01 ) . | null | hoc |
Your role as a medical expert involves annotating a provided clinical text to identify the presence of specific cancer-related hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the input text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | At the same time , curcumin had no effect on progress of cell cycle in primaty acute myelogenous leukemia at newly diagnosis , but could increase the peak of Sub-G1 ( P < 0.05 ) , and down-regulate the expression of Mcl-1 and up-regulate the expression of Bax and Bak with the difference being statistically significant . | Sustaining proliferative signaling (PS) | hoc |
Your responsibility as a medical expert is to review a given clinical text for the presence of specific cancer hallmarks. This is a multi-class classification task, and you should assign one or more labels from the provided list to the text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | The expression of P27kipl , P21wafl and pRbp- were elevated and that of cyclin D3 decreased in the presence of curcumin . | Sustaining proliferative signaling (PS), Evading growth suppressors (GS) | hoc |
Your role as a medical expert involves annotating a provided clinical text to identify the presence of specific cancer-related hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the input text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | These findings suggested that the Bcl-2 gene family indeed participated in the regulatory process of apoptosis induced by curcumin in HL-60 cells and AML cells . | Resisting cell death (CD) | hoc |
As a medical expert, your task is to analyze a given clinical text and identify specific cancer hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | Curcumin can induce apoptosis of primary acute myelogenous leukemic cells and disturb cell cycle progression of HL-60 cells . | Sustaining proliferative signaling (PS), Resisting cell death (CD) | hoc |
In your capacity as a medical expert, your task is to assess a provided clinical text for indications of specific cancer hallmarks. This is a multi-class classification challenge, and you should assign one or more labels from the list below to the text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | The mechanism appeared to be mediated by perturbing G0/G1 phases checkpoints which associated with up-regulation of P27kipl , P21wafl and pRbp- expression , and down-regulation of cyclin D3 . | Sustaining proliferative signaling (PS), Evading growth suppressors (GS) | hoc |
In your capacity as a medical expert, your task is to assess a provided clinical text for indications of specific cancer hallmarks. This is a multi-class classification challenge, and you should assign one or more labels from the list below to the text if they are applicable:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | The colon carcinoma cell line CC531 is metastatic to liver after splenic injection in syngeneic rats . | Activating invasion & metastasis (IM) | hoc |
As a medical expert, your task is to analyze a given clinical text and identify specific cancer hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | After repeated in vivo passages , a subline was selected that produced liver metastases at a considerably higher rate than the original cell line . | Activating invasion & metastasis (IM) | hoc |
In your role as a medical expert, you are tasked with examining a provided clinical text to identify specific cancer hallmarks. This is a multi-class classification assignment, and you should assign one or more labels from the list below to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | These cells were characterized by increased intracellular glutathione , proliferation and ability to restore glutathione after exposure to oxidative stress , thus indicating an elevated resistance to oxidative stress . | Tumor-promoting inflammation (TPI) | hoc |
As a medical expert, your task is to analyze a given clinical text and identify specific cancer hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | Furthermore , the increased metastatic ability was also accompanied by increased proliferation rate , adhesion to extracellular matrix proteins and endothelial cells , and secretion of a 60 kD matrix metalloproteinase . | Activating invasion & metastasis (IM) | hoc |
As a medical expert, your task is to analyze a given clinical text and identify specific cancer hallmarks. This task is a multi-class classification, and you are required to assign one or more labels from the following list to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | When cultured in vitro for a prolonged time ( more than 30 trypsinizations ) , the cells showed a reduced in vivo metastatic ability , reduced secretion of three metalloproteinases including the 60 kD proteinase , and reduced intracellular glutathione . | Activating invasion & metastasis (IM) | hoc |
In your role as a medical expert, you are tasked with examining a provided clinical text to identify specific cancer hallmarks. This is a multi-class classification assignment, and you should assign one or more labels from the list below to the text if they are relevant:
Sustaining proliferative signaling (PS)
Evading growth suppressors (GS)
Resisting cell death (CD)
Enabling replicative immortality (RI)
Inducing angiogenesis (A)
Activating invasion & metastasis (IM)
Genome instability & mutation (GI)
Tumor-promoting inflammation (TPI)
Deregulating cellular energetics (CE)
Avoiding immune destruction (ID)
None | These results indicate that metastatic ability can be influenced through several adaptive mechanisms , and that the cell's ability to resist oxidative stress and maintain intracellular glutathione are of central importance . | Activating invasion & metastasis (IM), Tumor-promoting inflammation (TPI) | hoc |
Subsets and Splits