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In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | Using reverse transcriptase combined with polymerase chain reactions in the analysis of a number of lipoma cell lines and primary lipomas , it appeared that LPP is frequently rearranged also in cases without a cytogenetically detectable involvement of 3q27 - q28 . | Using : O
reverse : O
transcriptase : O
combined : O
with : O
polymerase : O
chain : O
reactions : O
in : O
the : O
analysis : O
of : O
a : O
number : O
of : O
lipoma : B
cell : O
lines : O
and : O
primary : B
lipomas : I
, : O
it : O
appeared : O
that : O
LPP : O
is : O
frequently : O
rearranged : O
also : O
in : O
cases : O
without : O
a : O
cytogenetically : O
detectable : O
involvement : O
of : O
3q27 : O
- : O
q28 : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | Two alternative HMGIC / LPP hybrid transcripts have been detected ; the difference between them is mainly the presence of either two or three LIM domains in the predicted HMGI - C / LPP fusion proteins . . | Two : O
alternative : O
HMGIC : O
/ : O
LPP : O
hybrid : O
transcripts : O
have : O
been : O
detected : O
; : O
the : O
difference : O
between : O
them : O
is : O
mainly : O
the : O
presence : O
of : O
either : O
two : O
or : O
three : O
LIM : O
domains : O
in : O
the : O
predicted : O
HMGI : O
- : O
C : O
/ : O
LPP : O
fusion : O
proteins : O
. : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | Absence of disease phenotype and intergenerational stability of the CAG repeat in transgenic mice expressing the human Huntington disease transcript . | Absence : O
of : O
disease : O
phenotype : O
and : O
intergenerational : O
stability : O
of : O
the : O
CAG : O
repeat : O
in : O
transgenic : O
mice : O
expressing : O
the : O
human : O
Huntington : B
disease : I
transcript : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | The mutation underlying Huntington disease ( HD ) is CAG expansion in the first exon of the HD gene . | The : O
mutation : O
underlying : O
Huntington : B
disease : I
( : O
HD : B
) : O
is : O
CAG : O
expansion : O
in : O
the : O
first : O
exon : O
of : O
the : O
HD : B
gene : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | In order to investigate the role of CAG expansion in the pathogenesis of HD , we have produced transgenic mice containing the full length human HD cDNA with 44 CAG repeats . | In : O
order : O
to : O
investigate : O
the : O
role : O
of : O
CAG : O
expansion : O
in : O
the : O
pathogenesis : O
of : O
HD : B
, : O
we : O
have : O
produced : O
transgenic : O
mice : O
containing : O
the : O
full : O
length : O
human : O
HD : B
cDNA : O
with : O
44 : O
CAG : O
repeats : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | By 1 year , these mice have no behavioral abnormalities and morphometric analysis at 6 ( one animal ) and 9 ( two animals ) months age revealed no changes . | By : O
1 : O
year : O
, : O
these : O
mice : O
have : O
no : O
behavioral : B
abnormalities : I
and : O
morphometric : O
analysis : O
at : O
6 : O
( : O
one : O
animal : O
) : O
and : O
9 : O
( : O
two : O
animals : O
) : O
months : O
age : O
revealed : O
no : O
changes : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | Despite high levels of mRNA expression , there was no evidence of the HD gene product in any of these transgenic mice . | Despite : O
high : O
levels : O
of : O
mRNA : O
expression : O
, : O
there : O
was : O
no : O
evidence : O
of : O
the : O
HD : B
gene : O
product : O
in : O
any : O
of : O
these : O
transgenic : O
mice : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | In vitro transfection studies indicated that the inclusion of 120 bp of the 5 UTR in the cDNA construct and the presence of a frameshift mutation at nucleotide 2349 prevented expression of the HD cDNA . | In : O
vitro : O
transfection : O
studies : O
indicated : O
that : O
the : O
inclusion : O
of : O
120 : O
bp : O
of : O
the : O
5 : O
UTR : O
in : O
the : O
cDNA : O
construct : O
and : O
the : O
presence : O
of : O
a : O
frameshift : O
mutation : O
at : O
nucleotide : O
2349 : O
prevented : O
expression : O
of : O
the : O
HD : B
cDNA : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | These findings suggest that the pathogenesis of HD is not mediated through DNA - protein interaction and that presence of the RNA transcript with an expanded CAG repeat is insufficient to cause the disease . | These : O
findings : O
suggest : O
that : O
the : O
pathogenesis : O
of : O
HD : B
is : O
not : O
mediated : O
through : O
DNA : O
- : O
protein : O
interaction : O
and : O
that : O
presence : O
of : O
the : O
RNA : O
transcript : O
with : O
an : O
expanded : O
CAG : O
repeat : O
is : O
insufficient : O
to : O
cause : O
the : O
disease : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | Rather , translation of the CAG is crucial for the pathogenesis of HD . | Rather : O
, : O
translation : O
of : O
the : O
CAG : O
is : O
crucial : O
for : O
the : O
pathogenesis : O
of : O
HD : B
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | In contrast to that seen in humans , the CAG repeat in these mice was remarkably stable in 97 meioses . | In : O
contrast : O
to : O
that : O
seen : O
in : O
humans : O
, : O
the : O
CAG : O
repeat : O
in : O
these : O
mice : O
was : O
remarkably : O
stable : O
in : O
97 : O
meioses : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | This suggests that genomic sequences may play a critical role in influencing repeat instability . . | This : O
suggests : O
that : O
genomic : O
sequences : O
may : O
play : O
a : O
critical : O
role : O
in : O
influencing : O
repeat : O
instability : O
. : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | FISH studies in a patient with sporadic aniridia and t ( 7 ; 11 ) ( q31 . 2 ; p13 ) . | FISH : O
studies : O
in : O
a : O
patient : O
with : O
sporadic : B
aniridia : I
and : O
t : O
( : O
7 : O
; : O
11 : O
) : O
( : O
q31 : O
. : O
2 : O
; : O
p13 : O
) : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | A 2 year old female presenting with bilateral sporadic aniridia was found to have an apparently balanced reciprocal translocation with a chromosome 11 breakpoint within band p13 . | A : O
2 : O
year : O
old : O
female : O
presenting : O
with : O
bilateral : B
sporadic : I
aniridia : I
was : O
found : O
to : O
have : O
an : O
apparently : O
balanced : O
reciprocal : O
translocation : O
with : O
a : O
chromosome : O
11 : O
breakpoint : O
within : O
band : O
p13 : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | Fluorescence in situ hybridisation ( FISH ) studies with distal 11p13 specific cosmids showed that the chromosome 11 breakpoint lay between the aniridia ( PAX6 ) locus and a region approximately 100 kb distal to PAX6 defined by the cosmid FO2121 . | Fluorescence : O
in : O
situ : O
hybridisation : O
( : O
FISH : O
) : O
studies : O
with : O
distal : O
11p13 : O
specific : O
cosmids : O
showed : O
that : O
the : O
chromosome : O
11 : O
breakpoint : O
lay : O
between : O
the : O
aniridia : B
( : O
PAX6 : O
) : O
locus : O
and : O
a : O
region : O
approximately : O
100 : O
kb : O
distal : O
to : O
PAX6 : O
defined : O
by : O
the : O
cosmid : O
FO2121 : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | Although this patient did not have a detectable deletion within PAX6 , her aniridia may have resulted from a disruption of the distal chromatin domain containing either enhancers or regulators for PAX6 . | Although : O
this : O
patient : O
did : O
not : O
have : O
a : O
detectable : O
deletion : O
within : O
PAX6 : O
, : O
her : O
aniridia : B
may : O
have : O
resulted : O
from : O
a : O
disruption : O
of : O
the : O
distal : O
chromatin : O
domain : O
containing : O
either : O
enhancers : O
or : O
regulators : O
for : O
PAX6 : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | This case may therefore be another example of aniridia caused by a position effect as recently described in two familial aniridia patients in which the phenotype cosegregated with chromosome abnormalities with 11p13 breakpoints . . | This : O
case : O
may : O
therefore : O
be : O
another : O
example : O
of : O
aniridia : B
caused : O
by : O
a : O
position : O
effect : O
as : O
recently : O
described : O
in : O
two : O
familial : B
aniridia : I
patients : O
in : O
which : O
the : O
phenotype : O
cosegregated : O
with : O
chromosome : B
abnormalities : I
with : O
11p13 : O
breakpoints : O
. : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | Muscle expression of glucose - 6 - phosphate dehydrogenase deficiency in different variants . | Muscle : O
expression : O
of : O
glucose : B
- : I
6 : I
- : I
phosphate : I
dehydrogenase : I
deficiency : I
in : O
different : O
variants : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | Muscle expression of G6PD deficiency has been investigated in Mediterranean , Seattle - like and A - variants . | Muscle : O
expression : O
of : O
G6PD : B
deficiency : I
has : O
been : O
investigated : O
in : O
Mediterranean : O
, : O
Seattle : O
- : O
like : O
and : O
A : O
- : O
variants : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | G6PD activity was detected in samples obtained from biopsies on the quadriceps muscle of seven males and one female . | G6PD : O
activity : O
was : O
detected : O
in : O
samples : O
obtained : O
from : O
biopsies : O
on : O
the : O
quadriceps : O
muscle : O
of : O
seven : O
males : O
and : O
one : O
female : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | The type of genetic variant was determined by molecular analysis of DNA , extracted from blood samples . | The : O
type : O
of : O
genetic : O
variant : O
was : O
determined : O
by : O
molecular : O
analysis : O
of : O
DNA : O
, : O
extracted : O
from : O
blood : O
samples : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | All variants showed the enzyme defect in muscle . | All : O
variants : O
showed : O
the : O
enzyme : O
defect : O
in : O
muscle : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | A statistically significant relationship was found in the activity of G6PD between erythrocytes and muscle of the male subjects ( r = 0 . 968 ; p = 0 . 00008 ) . | A : O
statistically : O
significant : O
relationship : O
was : O
found : O
in : O
the : O
activity : O
of : O
G6PD : O
between : O
erythrocytes : O
and : O
muscle : O
of : O
the : O
male : O
subjects : O
( : O
r : O
= : O
0 : O
. : O
968 : O
; : O
p : O
= : O
0 : O
. : O
00008 : O
) : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | The equation for the best fit line was Y = 0 . | The : O
equation : O
for : O
the : O
best : O
fit : O
line : O
was : O
Y : O
= : O
0 : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | 390X + 0 . | 390X : O
+ : O
0 : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | 198 198 . | 198 : O
198 : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | The results suggest that , for a given variant , the extent of the enzyme defect in muscle may be determined , using this equation , from the G6PD activity of erythrocytes | The : O
results : O
suggest : O
that : O
, : O
for : O
a : O
given : O
variant : O
, : O
the : O
extent : O
of : O
the : O
enzyme : O
defect : O
in : O
muscle : O
may : O
be : O
determined : O
, : O
using : O
this : O
equation : O
, : O
from : O
the : O
G6PD : O
activity : O
of : O
erythrocytes : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | Gene therapy for phenylketonuria . | Gene : O
therapy : O
for : O
phenylketonuria : B
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | Classical phenylketonuria ( PKU ) is an autosomal recessive disorder caused by a deficiency of hepatic phenylalanine hydroxylase ( PAH ) . | Classical : O
phenylketonuria : B
( : O
PKU : B
) : O
is : O
an : O
autosomal : B
recessive : I
disorder : I
caused : O
by : O
a : O
deficiency : B
of : I
hepatic : I
phenylalanine : I
hydroxylase : I
( : O
PAH : O
) : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | Limitations of the current dietary treatment for PKU have led to the development of potential treatments based on somatic gene transfer . | Limitations : O
of : O
the : O
current : O
dietary : O
treatment : O
for : O
PKU : B
have : O
led : O
to : O
the : O
development : O
of : O
potential : O
treatments : O
based : O
on : O
somatic : O
gene : O
transfer : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | Three different vector systems have been examined . | Three : O
different : O
vector : O
systems : O
have : O
been : O
examined : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | Vectors derived from a recombinant retrovirus or a DNA / protein complex can efficiently transduce the PAH cDNA into PAH - deficient hepatocytes in vitro , but the application of these vector systems is presently limited by their low transduction efficiency in vivo . | Vectors : O
derived : O
from : O
a : O
recombinant : O
retrovirus : O
or : O
a : O
DNA : O
/ : O
protein : O
complex : O
can : O
efficiently : O
transduce : O
the : O
PAH : O
cDNA : O
into : O
PAH : B
- : I
deficient : I
hepatocytes : O
in : O
vitro : O
, : O
but : O
the : O
application : O
of : O
these : O
vector : O
systems : O
is : O
presently : O
limited : O
by : O
their : O
low : O
transduction : O
efficiency : O
in : O
vivo : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | In contrast , a vector derived from a recombinant adenovirus can restore 10 % - 80 % of normal hepatic PAH activity into PAH - deficient mice , which completely normalizes serum phenylalanine levels . | In : O
contrast : O
, : O
a : O
vector : O
derived : O
from : O
a : O
recombinant : O
adenovirus : O
can : O
restore : O
10 : O
% : O
- : O
80 : O
% : O
of : O
normal : O
hepatic : O
PAH : O
activity : O
into : O
PAH : B
- : I
deficient : I
mice : O
, : O
which : O
completely : O
normalizes : O
serum : O
phenylalanine : O
levels : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | This treatment is transient and cannot be effectively re - administered due to the presence of neutralizing antibodies directed against the recombinant adenoviral vector . | This : O
treatment : O
is : O
transient : O
and : O
cannot : O
be : O
effectively : O
re : O
- : O
administered : O
due : O
to : O
the : O
presence : O
of : O
neutralizing : O
antibodies : O
directed : O
against : O
the : O
recombinant : O
adenoviral : O
vector : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | However , these findings suggest that PKU can be completely corrected by somatic gene therapy , and provide some direction for the future development of adenoviral vectors . . | However : O
, : O
these : O
findings : O
suggest : O
that : O
PKU : B
can : O
be : O
completely : O
corrected : O
by : O
somatic : O
gene : O
therapy : O
, : O
and : O
provide : O
some : O
direction : O
for : O
the : O
future : O
development : O
of : O
adenoviral : O
vectors : O
. : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | Exon - intron structure of the human neuronal nicotinic acetylcholine receptor alpha 4 subunit ( CHRNA4 ) . | Exon : O
- : O
intron : O
structure : O
of : O
the : O
human : O
neuronal : O
nicotinic : O
acetylcholine : O
receptor : O
alpha : O
4 : O
subunit : O
( : O
CHRNA4 : O
) : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | The human neuronal nicotinic acetylcholine receptor alpha 4 subunit gene ( CHRNA4 ) is located in the candidate region for three different phenotypes benign familial neonatal convulsions , autosomal dominant nocturnal frontal lobe epilepsy , and low - voltage EEG . | The : O
human : O
neuronal : O
nicotinic : O
acetylcholine : O
receptor : O
alpha : O
4 : O
subunit : O
gene : O
( : O
CHRNA4 : O
) : O
is : O
located : O
in : O
the : O
candidate : O
region : O
for : O
three : O
different : O
phenotypes : O
benign : B
familial : I
neonatal : I
convulsions : I
, : O
autosomal : B
dominant : I
nocturnal : I
frontal : I
lobe : I
epilepsy : I
, : O
and : O
low : O
- : O
voltage : O
EEG : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | Recently , a missense mutation in transmembrane domain 2 of CHRNA4 was found to be associated with autosomal dominant nocturnal frontal lobe epilepsy in one extended pedigree . | Recently : O
, : O
a : O
missense : O
mutation : O
in : O
transmembrane : O
domain : O
2 : O
of : O
CHRNA4 : O
was : O
found : O
to : O
be : O
associated : O
with : O
autosomal : B
dominant : I
nocturnal : I
frontal : I
lobe : I
epilepsy : I
in : O
one : O
extended : O
pedigree : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | We have determined the genomic organization of CHRNA4 , which consists of six exons distributed over approximately 17 kb of genomic DNA . | We : O
have : O
determined : O
the : O
genomic : O
organization : O
of : O
CHRNA4 : O
, : O
which : O
consists : O
of : O
six : O
exons : O
distributed : O
over : O
approximately : O
17 : O
kb : O
of : O
genomic : O
DNA : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | The nucleotide sequence obtained from the genomic regions adjacent to the exon boundaries enabled us to develop a set of primer pairs for PCR amplification of the complete coding region . | The : O
nucleotide : O
sequence : O
obtained : O
from : O
the : O
genomic : O
regions : O
adjacent : O
to : O
the : O
exon : O
boundaries : O
enabled : O
us : O
to : O
develop : O
a : O
set : O
of : O
primer : O
pairs : O
for : O
PCR : O
amplification : O
of : O
the : O
complete : O
coding : O
region : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | The sequence analysis provides the basis for a comprehensive mutation screening of CHRNA4 in the above - mentioned phenotypes and possibly in other types of idiopathic epilepsies . . | The : O
sequence : O
analysis : O
provides : O
the : O
basis : O
for : O
a : O
comprehensive : O
mutation : O
screening : O
of : O
CHRNA4 : O
in : O
the : O
above : O
- : O
mentioned : O
phenotypes : O
and : O
possibly : O
in : O
other : O
types : O
of : O
idiopathic : B
epilepsies : I
. : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | Ashkenazi Jewish population frequencies for common mutations in BRCA1 and BRCA2 . | Ashkenazi : O
Jewish : O
population : O
frequencies : O
for : O
common : O
mutations : O
in : O
BRCA1 : O
and : O
BRCA2 : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | BRCA1 and BRCA2 are the two major identified causes of inherited breast cancer , with mutations in either gene conferring up to 80 - 90 % lifetime risk of breast cancer in carrier females . | BRCA1 : O
and : O
BRCA2 : O
are : O
the : O
two : O
major : O
identified : O
causes : O
of : O
inherited : B
breast : I
cancer : I
, : O
with : O
mutations : O
in : O
either : O
gene : O
conferring : O
up : O
to : O
80 : O
- : O
90 : O
% : O
lifetime : O
risk : O
of : O
breast : B
cancer : I
in : O
carrier : O
females : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | Mutations in BRCA1 account for approximately 45 % of familial breast cancer and 90 % of inherited breast / ovarian cancer , whereas mutations in BRCA2 account for a comparable percentage of inherited breast cancer cases . | Mutations : O
in : O
BRCA1 : O
account : O
for : O
approximately : O
45 : O
% : O
of : O
familial : B
breast : I
cancer : I
and : O
90 : O
% : O
of : O
inherited : B
breast : I
/ : I
ovarian : I
cancer : I
, : O
whereas : O
mutations : O
in : O
BRCA2 : O
account : O
for : O
a : O
comparable : O
percentage : O
of : O
inherited : B
breast : I
cancer : I
cases : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | Over 85 distinct BRCA1 mutations and a growing list of BRCA2 mutations have been identified , with the majority resulting in protein truncation . | Over : O
85 : O
distinct : O
BRCA1 : O
mutations : O
and : O
a : O
growing : O
list : O
of : O
BRCA2 : O
mutations : O
have : O
been : O
identified : O
, : O
with : O
the : O
majority : O
resulting : O
in : O
protein : O
truncation : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | A specific BRCA1 mutation , 185delAG , has a reported increased carrier frequency of approximately 0 . | A : O
specific : O
BRCA1 : O
mutation : O
, : O
185delAG : O
, : O
has : O
a : O
reported : O
increased : O
carrier : O
frequency : O
of : O
approximately : O
0 : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | 9 % in the Ashkenazi Jewish population , but is also found in rare non - Jewish patients with a different haplotype . | 9 : O
% : O
in : O
the : O
Ashkenazi : O
Jewish : O
population : O
, : O
but : O
is : O
also : O
found : O
in : O
rare : O
non : O
- : O
Jewish : O
patients : O
with : O
a : O
different : O
haplotype : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | The 6174delT mutation in BRCA2 was recently identified as a frequent mutation in 8 out of 107 Ashkenazi Jewish women diagnosed with breast cancer by age 50 ( ref . 8 ) , as well as in three Ashkenazi male breast cancer patients . | The : O
6174delT : O
mutation : O
in : O
BRCA2 : O
was : O
recently : O
identified : O
as : O
a : O
frequent : O
mutation : O
in : O
8 : O
out : O
of : O
107 : O
Ashkenazi : O
Jewish : O
women : O
diagnosed : O
with : O
breast : B
cancer : I
by : O
age : O
50 : O
( : O
ref : O
. : O
8 : O
) : O
, : O
as : O
well : O
as : O
in : O
three : O
Ashkenazi : O
male : B
breast : I
cancer : I
patients : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | We have conducted a large - scale population study to investigate the prevalence of specific BRCA1 and BRCA2 mutations in Ashkenazi Jewish individuals who were unselected for breast cancer . | We : O
have : O
conducted : O
a : O
large : O
- : O
scale : O
population : O
study : O
to : O
investigate : O
the : O
prevalence : O
of : O
specific : O
BRCA1 : O
and : O
BRCA2 : O
mutations : O
in : O
Ashkenazi : O
Jewish : O
individuals : O
who : O
were : O
unselected : O
for : O
breast : B
cancer : I
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | BRCA1 mutation screening on approximately 3 , 000 Ashkenazi Jewish samples determined a carrier frequency of 1 . | BRCA1 : O
mutation : O
screening : O
on : O
approximately : O
3 : O
, : O
000 : O
Ashkenazi : O
Jewish : O
samples : O
determined : O
a : O
carrier : O
frequency : O
of : O
1 : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | 09 % for the 185delAG mutation and 0 . | 09 : O
% : O
for : O
the : O
185delAG : O
mutation : O
and : O
0 : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | 13 % for the 5382insC mutation . | 13 : O
% : O
for : O
the : O
5382insC : O
mutation : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | BRCA2 analysis on 3 , 085 individuals from the same population showed a carrier frequency of 1 . | BRCA2 : O
analysis : O
on : O
3 : O
, : O
085 : O
individuals : O
from : O
the : O
same : O
population : O
showed : O
a : O
carrier : O
frequency : O
of : O
1 : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | 52 % for the 6174delT mutation . | 52 : O
% : O
for : O
the : O
6174delT : O
mutation : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | This expanded population - based study confirms that the BRCA1 185delAG mutation and the BRCA2 6174delT mutation constitute the two most frequent mutation alleles predisposing to hereditary breast cancer among the Ashkenazim , and suggests a relatively lower penetrance for the 6174delT mutation in BRCA2 | This : O
expanded : O
population : O
- : O
based : O
study : O
confirms : O
that : O
the : O
BRCA1 : O
185delAG : O
mutation : O
and : O
the : O
BRCA2 : O
6174delT : O
mutation : O
constitute : O
the : O
two : O
most : O
frequent : O
mutation : O
alleles : O
predisposing : O
to : O
hereditary : B
breast : I
cancer : I
among : O
the : O
Ashkenazim : O
, : O
and : O
suggests : O
a : O
relatively : O
lower : O
penetrance : O
for : O
the : O
6174delT : O
mutation : O
in : O
BRCA2 : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | Dual roles of ATM in the cellular response to radiation and in cell growth control . | Dual : O
roles : O
of : O
ATM : O
in : O
the : O
cellular : O
response : O
to : O
radiation : O
and : O
in : O
cell : O
growth : O
control : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | The gene mutated in ataxia - telangiectasia ( AT ) patients , denoted ATM , encodes a putative protein or lipid kinase . | The : O
gene : O
mutated : O
in : O
ataxia : B
- : I
telangiectasia : I
( : O
AT : B
) : O
patients : O
, : O
denoted : O
ATM : O
, : O
encodes : O
a : O
putative : O
protein : O
or : O
lipid : O
kinase : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | To elucidate the functions of ATM , we disrupted the mouse ATM gene through homologous recombination in mice . | To : O
elucidate : O
the : O
functions : O
of : O
ATM : O
, : O
we : O
disrupted : O
the : O
mouse : O
ATM : O
gene : O
through : O
homologous : O
recombination : O
in : O
mice : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | Consistent with cellular defects of AT patients , the ATM - / - cells are hypersensitive to gamma - irradiation and defective in cell - cycle arrest following radiation , correlating with a defective up - regulation of p53 . | Consistent : O
with : O
cellular : O
defects : O
of : O
AT : B
patients : O
, : O
the : O
ATM : O
- : O
/ : O
- : O
cells : O
are : O
hypersensitive : O
to : O
gamma : O
- : O
irradiation : O
and : O
defective : O
in : O
cell : O
- : O
cycle : O
arrest : O
following : O
radiation : O
, : O
correlating : O
with : O
a : O
defective : O
up : O
- : O
regulation : O
of : O
p53 : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | In addition , ATM - / - mouse thymocytes are more resistant to apoptosis induced by gamma - irradiation than normal thymocytes . | In : O
addition : O
, : O
ATM : O
- : O
/ : O
- : O
mouse : O
thymocytes : O
are : O
more : O
resistant : O
to : O
apoptosis : O
induced : O
by : O
gamma : O
- : O
irradiation : O
than : O
normal : O
thymocytes : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | ATM - / - fibroblasts are inefficient in G1 to S - phase progression following serum stimulation and senesce after only a few passages in culture . | ATM : O
- : O
/ : O
- : O
fibroblasts : O
are : O
inefficient : O
in : O
G1 : O
to : O
S : O
- : O
phase : O
progression : O
following : O
serum : O
stimulation : O
and : O
senesce : O
after : O
only : O
a : O
few : O
passages : O
in : O
culture : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | They have an increased constitutive level of p21CP1 / WAF1 . | They : O
have : O
an : O
increased : O
constitutive : O
level : O
of : O
p21CP1 : O
/ : O
WAF1 : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | The ATM protein is therefore critical both for cellular responses to ionizing radiation and for normal cell - cycle progression . | The : O
ATM : O
protein : O
is : O
therefore : O
critical : O
both : O
for : O
cellular : O
responses : O
to : O
ionizing : O
radiation : O
and : O
for : O
normal : O
cell : O
- : O
cycle : O
progression : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | ATM + / - fibroblasts and thymocytes showed intermediately defective responses to irradiation but no growth defect , suggesting that the increased cancer risk of AT heterozygotes could be attributable to poor checkpoint function . . | ATM : O
+ : O
/ : O
- : O
fibroblasts : O
and : O
thymocytes : O
showed : O
intermediately : O
defective : O
responses : O
to : O
irradiation : O
but : O
no : O
growth : O
defect : O
, : O
suggesting : O
that : O
the : O
increased : O
cancer : B
risk : O
of : O
AT : B
heterozygotes : O
could : O
be : O
attributable : O
to : O
poor : O
checkpoint : O
function : O
. : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | Targeted disruption of ATM leads to growth retardation , chromosomal fragmentation during meiosis , immune defects , and thymic lymphoma . | Targeted : O
disruption : O
of : O
ATM : O
leads : O
to : O
growth : B
retardation : I
, : O
chromosomal : B
fragmentation : I
during : I
meiosis : I
, : O
immune : B
defects : I
, : O
and : O
thymic : B
lymphoma : I
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | ATM , the gene mutated in the inherited human disease ataxia - telangiectasia , is a member of a family of kinases involved in DNA metabolism and cell - cycle checkpoint control . | ATM : O
, : O
the : O
gene : O
mutated : O
in : O
the : O
inherited : B
human : I
disease : I
ataxia : B
- : I
telangiectasia : I
, : O
is : O
a : O
member : O
of : O
a : O
family : O
of : O
kinases : O
involved : O
in : O
DNA : O
metabolism : O
and : O
cell : O
- : O
cycle : O
checkpoint : O
control : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | To help clarify the physiological roles of the ATM protein , we disrupted the ATM gene in mice through homologous recombination . | To : O
help : O
clarify : O
the : O
physiological : O
roles : O
of : O
the : O
ATM : O
protein : O
, : O
we : O
disrupted : O
the : O
ATM : O
gene : O
in : O
mice : O
through : O
homologous : O
recombination : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | Initial evaluation of the ATM knockout animals indicates that inactivation of the mouse ATM gene recreates much of the phenotype of ataxia - telangiectasia . | Initial : O
evaluation : O
of : O
the : O
ATM : O
knockout : O
animals : O
indicates : O
that : O
inactivation : O
of : O
the : O
mouse : O
ATM : O
gene : O
recreates : O
much : O
of : O
the : O
phenotype : O
of : O
ataxia : B
- : I
telangiectasia : I
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | The homozygous mutant ( ATM - / - ) mice are viable , growth - retarded , and infertile . | The : O
homozygous : O
mutant : O
( : O
ATM : O
- : O
/ : O
- : O
) : O
mice : O
are : O
viable : O
, : O
growth : O
- : O
retarded : O
, : O
and : O
infertile : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | The infertility of ATM - / - mice results from meiotic failure . | The : O
infertility : B
of : O
ATM : O
- : O
/ : O
- : O
mice : O
results : O
from : O
meiotic : O
failure : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | Meiosis is arrested at the zygotene / pachytene stage of prophase I as a result of abnormal chromosomal synapsis and subsequent chromosome fragmentation . | Meiosis : O
is : O
arrested : O
at : O
the : O
zygotene : O
/ : O
pachytene : O
stage : O
of : O
prophase : O
I : O
as : O
a : O
result : O
of : O
abnormal : O
chromosomal : O
synapsis : O
and : O
subsequent : O
chromosome : O
fragmentation : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | Immune defects also are evident in ATM - / - mice , including reduced numbers of B220 + CD43 - pre - B cells , thymocytes , and peripheral T cells , as well as functional impairment of T - cell - dependent immune responses . | Immune : B
defects : I
also : O
are : O
evident : O
in : O
ATM : O
- : O
/ : O
- : O
mice : O
, : O
including : O
reduced : O
numbers : O
of : O
B220 : O
+ : O
CD43 : O
- : O
pre : O
- : O
B : O
cells : O
, : O
thymocytes : O
, : O
and : O
peripheral : O
T : O
cells : O
, : O
as : O
well : O
as : O
functional : O
impairment : O
of : O
T : O
- : O
cell : O
- : O
dependent : O
immune : O
responses : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | The cerebella of ATM - / - mice appear normal by histologic examination at 3 to 4 months and the mice have no gross behavioral abnormalities . | The : O
cerebella : O
of : O
ATM : O
- : O
/ : O
- : O
mice : O
appear : O
normal : O
by : O
histologic : O
examination : O
at : O
3 : O
to : O
4 : O
months : O
and : O
the : O
mice : O
have : O
no : O
gross : O
behavioral : B
abnormalities : I
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | The majority of mutant mice rapidly develop thymic lymphomas and die before 4 months of age . | The : O
majority : O
of : O
mutant : O
mice : O
rapidly : O
develop : O
thymic : B
lymphomas : I
and : O
die : O
before : O
4 : O
months : O
of : O
age : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | These findings indicate that the ATM gene product plays an essential role in a diverse group of cellular processes , including meiosis , the normal growth of somatic tissues , immune development , and tumor suppression . . | These : O
findings : O
indicate : O
that : O
the : O
ATM : O
gene : O
product : O
plays : O
an : O
essential : O
role : O
in : O
a : O
diverse : O
group : O
of : O
cellular : O
processes : O
, : O
including : O
meiosis : O
, : O
the : O
normal : O
growth : O
of : O
somatic : O
tissues : O
, : O
immune : O
development : O
, : O
and : O
tumor : B
suppression : O
. : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | Cloning and characterization of human very - long - chain acyl - CoA dehydrogenase cDNA , chromosomal assignment of the gene and identification in four patients of nine different mutations within the VLCAD gene . | Cloning : O
and : O
characterization : O
of : O
human : O
very : O
- : O
long : O
- : O
chain : O
acyl : O
- : O
CoA : O
dehydrogenase : O
cDNA : O
, : O
chromosomal : O
assignment : O
of : O
the : O
gene : O
and : O
identification : O
in : O
four : O
patients : O
of : O
nine : O
different : O
mutations : O
within : O
the : O
VLCAD : O
gene : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | Very - long - chain acyl - CoA dehydrogenase ( VLCAD ) is one of four straight - chain acyl - CoA dehydrogenase ( ACD ) enzymes , which are all nuclear encoded mitochondrial flavoproteins catalyzing the initial step in fatty acid beta - oxidation . | Very : O
- : O
long : O
- : O
chain : O
acyl : O
- : O
CoA : O
dehydrogenase : O
( : O
VLCAD : O
) : O
is : O
one : O
of : O
four : O
straight : O
- : O
chain : O
acyl : O
- : O
CoA : O
dehydrogenase : O
( : O
ACD : O
) : O
enzymes : O
, : O
which : O
are : O
all : O
nuclear : O
encoded : O
mitochondrial : O
flavoproteins : O
catalyzing : O
the : O
initial : O
step : O
in : O
fatty : O
acid : O
beta : O
- : O
oxidation : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | We have used the very fast , Rapid Amplification of cDNA Ends ( RACE ) based strategy to obtain the sequence of cDNAs encoding human VLCAD from placenta and fibroblasts . | We : O
have : O
used : O
the : O
very : O
fast : O
, : O
Rapid : O
Amplification : O
of : O
cDNA : O
Ends : O
( : O
RACE : O
) : O
based : O
strategy : O
to : O
obtain : O
the : O
sequence : O
of : O
cDNAs : O
encoding : O
human : O
VLCAD : O
from : O
placenta : O
and : O
fibroblasts : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | Alignment of the predicted amino acid sequence of human VLCAD with those of the other human ACD enzymes revealed extensive sequence homology . | Alignment : O
of : O
the : O
predicted : O
amino : O
acid : O
sequence : O
of : O
human : O
VLCAD : O
with : O
those : O
of : O
the : O
other : O
human : O
ACD : O
enzymes : O
revealed : O
extensive : O
sequence : O
homology : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | Moreover , human VLCAD and human acyl - CoA oxidase showed extensive sequence homology corroborating the notion that these genes are evolutionarily related . | Moreover : O
, : O
human : O
VLCAD : O
and : O
human : O
acyl : O
- : O
CoA : O
oxidase : O
showed : O
extensive : O
sequence : O
homology : O
corroborating : O
the : O
notion : O
that : O
these : O
genes : O
are : O
evolutionarily : O
related : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | Southern blot analysis of genomic DNA from hybrid cell lines was used to localize the VLCAD gene to human chromosome 17p11 . | Southern : O
blot : O
analysis : O
of : O
genomic : O
DNA : O
from : O
hybrid : O
cell : O
lines : O
was : O
used : O
to : O
localize : O
the : O
VLCAD : O
gene : O
to : O
human : O
chromosome : O
17p11 : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | 2 - p11 . | 2 : O
- : O
p11 : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | 13105 . | 13105 : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | Using Northern and Western blot analysis to investigate the tissue specific distribution of VLCAD mRNA and protein in several human tissues we showed that VLCAD is most abundant in heart and skeletal muscle . | Using : O
Northern : O
and : O
Western : O
blot : O
analysis : O
to : O
investigate : O
the : O
tissue : O
specific : O
distribution : O
of : O
VLCAD : O
mRNA : O
and : O
protein : O
in : O
several : O
human : O
tissues : O
we : O
showed : O
that : O
VLCAD : O
is : O
most : O
abundant : O
in : O
heart : O
and : O
skeletal : O
muscle : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | This agrees well with the fact that cardiac and muscle symptoms are characteristic for patients with VLCAD deficiency . | This : O
agrees : O
well : O
with : O
the : O
fact : O
that : O
cardiac : O
and : O
muscle : O
symptoms : O
are : O
characteristic : O
for : O
patients : O
with : O
VLCAD : B
deficiency : I
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | Northern blot analysis and sequencing of cloned PCR amplified VLCAD cDNA from four unrelated patients with VLCAD deficiency showed that VLCAD mRNA was undetectable in one patient and that the other three have mutations in both VLCAD alleles . | Northern : O
blot : O
analysis : O
and : O
sequencing : O
of : O
cloned : O
PCR : O
amplified : O
VLCAD : O
cDNA : O
from : O
four : O
unrelated : O
patients : O
with : O
VLCAD : B
deficiency : I
showed : O
that : O
VLCAD : O
mRNA : O
was : O
undetectable : O
in : O
one : O
patient : O
and : O
that : O
the : O
other : O
three : O
have : O
mutations : O
in : O
both : O
VLCAD : O
alleles : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | Western blot analysis of patient fibroblasts showed that the identified mutations result in severely reduced amounts of VLCAD protein . | Western : O
blot : O
analysis : O
of : O
patient : O
fibroblasts : O
showed : O
that : O
the : O
identified : O
mutations : O
result : O
in : O
severely : O
reduced : O
amounts : O
of : O
VLCAD : O
protein : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | Molecular bases of combined subtotal deficiencies of C6 and C7 : their effects in combination with other C6 and C7 deficiencies . | Molecular : O
bases : O
of : O
combined : B
subtotal : I
deficiencies : I
of : I
C6 : I
and : I
C7 : I
: : O
their : O
effects : O
in : O
combination : O
with : O
other : O
C6 : B
and : I
C7 : I
deficiencies : I
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | Combined subtotal deficiency of C6 and C7 , in which both proteins are expressed at very low levels , has been observed in homozygous form in two families . | Combined : B
subtotal : I
deficiency : I
of : I
C6 : I
and : I
C7 : I
, : O
in : O
which : O
both : O
proteins : O
are : O
expressed : O
at : O
very : O
low : O
levels : O
, : O
has : O
been : O
observed : O
in : O
homozygous : O
form : O
in : O
two : O
families : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | A defect at the 5 splice donor site of intron 15 of the C6 gene explains the low molecular weight of the C6 protein and is probably responsible for its low expressed concentration . | A : O
defect : O
at : O
the : O
5 : O
splice : O
donor : O
site : O
of : O
intron : O
15 : O
of : O
the : O
C6 : O
gene : O
explains : O
the : O
low : O
molecular : O
weight : O
of : O
the : O
C6 : O
protein : O
and : O
is : O
probably : O
responsible : O
for : O
its : O
low : O
expressed : O
concentration : O
. : O | NCBI-disease |
In the provided text, your objective is to recognize and label Named Entities associated with diseases using the BIO labeling scheme. Start by marking the beginning of a disease-related phrase with B (Begin), and then continue with I (Inner) for the subsequent words within that phrase. Non-disease words should be labeled as O. | The C7 defect is more enigmatic the protein is of normal molecular weight , low circulating concentration , and altered isoelectric point . | The : O
C7 : O
defect : O
is : O
more : O
enigmatic : O
the : O
protein : O
is : O
of : O
normal : O
molecular : O
weight : O
, : O
low : O
circulating : O
concentration : O
, : O
and : O
altered : O
isoelectric : O
point : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | An Arg > Ser codon substitution in exon 11 is the only molecular alteration within the mature C7 protein . | An : O
Arg : O
> : O
Ser : O
codon : O
substitution : O
in : O
exon : O
11 : O
is : O
the : O
only : O
molecular : O
alteration : O
within : O
the : O
mature : O
C7 : O
protein : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | These defects are associated with a characteristic set of polymorphic DNA markers in the C6 / C7 region , forming a distinct haplotype . | These : O
defects : O
are : O
associated : O
with : O
a : O
characteristic : O
set : O
of : O
polymorphic : O
DNA : O
markers : O
in : O
the : O
C6 : O
/ : O
C7 : O
region : O
, : O
forming : O
a : O
distinct : O
haplotype : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | The haplotype has been found in combination with a number of other haplotypes containing defective genes that lead either to C6 or C7 deficiency , but with different consequences . | The : O
haplotype : O
has : O
been : O
found : O
in : O
combination : O
with : O
a : O
number : O
of : O
other : O
haplotypes : O
containing : O
defective : O
genes : O
that : O
lead : O
either : O
to : O
C6 : B
or : I
C7 : I
deficiency : I
, : O
but : O
with : O
different : O
consequences : O
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | Where it is combined with a C6 - deficient gene , the serum C7 levels can be surprisingly high , possibly because there is no C6 generating C56 to consume the C7 . | Where : O
it : O
is : O
combined : O
with : O
a : O
C6 : B
- : I
deficient : I
gene : O
, : O
the : O
serum : O
C7 : O
levels : O
can : O
be : O
surprisingly : O
high : O
, : O
possibly : O
because : O
there : O
is : O
no : O
C6 : O
generating : O
C56 : O
to : O
consume : O
the : O
C7 : O
. : O | NCBI-disease |
Your goal is to detect disease-related Named Entities within the text and apply the BIO labeling scheme. Begin by labeling the first word of a disease-related phrase as B (Begin), and then label the subsequent words in that phrase as I (Inner). Any words not related to diseases should be labeled as O. | In contrast , where the C7 genes are both defective ( but still partially functional ) , there may be a profound deficit of circulating C7 because there is ample C6 to produce C56 and consume the already small amount of C7 . | In : O
contrast : O
, : O
where : O
the : O
C7 : O
genes : O
are : O
both : O
defective : O
( : O
but : O
still : O
partially : O
functional : O
) : O
, : O
there : O
may : O
be : O
a : O
profound : O
deficit : O
of : O
circulating : O
C7 : O
because : O
there : O
is : O
ample : O
C6 : O
to : O
produce : O
C56 : O
and : O
consume : O
the : O
already : O
small : O
amount : O
of : O
C7 : O
. : O | NCBI-disease |
Your task is to spot mentions of diseases in the text and apply the BIO labeling scheme. For each disease-related phrase, label the initial word as B (Begin), and label the rest of the words in the phrase as I (Inner). Any words unrelated to diseases should receive an O label. | Each molecular defect has also been found in isolation and has the expected effect . . | Each : O
molecular : O
defect : O
has : O
also : O
been : O
found : O
in : O
isolation : O
and : O
has : O
the : O
expected : O
effect : O
. : O
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | Genetic bases of human complement C7 deficiency . | Genetic : O
bases : O
of : O
human : O
complement : B
C7 : I
deficiency : I
. : O | NCBI-disease |
Your objective is to find instances of diseases within the input text and apply the BIO labeling scheme. Label the first word of each disease-related phrase as B (Begin), and subsequently label the other words in the same phrase as I (Inner). Any words that do not pertain to diseases should be labeled as O. | Complement C7 deficiency ( C7D ) is associated frequently with recurrent bacterial infections , especially meningitis caused by Neisseria meningitidis . | Complement : B
C7 : I
deficiency : I
( : O
C7D : B
) : O
is : O
associated : O
frequently : O
with : O
recurrent : O
bacterial : B
infections : I
, : O
especially : O
meningitis : B
caused : O
by : O
Neisseria : B
meningitidis : I
. : O | NCBI-disease |
In the given text, your mission is to identify Named Entities referring to diseases and employ the BIO labeling scheme. Mark the start of a disease-related phrase with B (Begin), followed by I (Inner) for the remaining words within that phrase. All non-disease terms should be labeled as O. | We report in this work the molecular bases of C7D in two unrelated Japanese males . | We : O
report : O
in : O
this : O
work : O
the : O
molecular : O
bases : O
of : O
C7D : B
in : O
two : O
unrelated : O
Japanese : O
males : O
. : O | NCBI-disease |
Subsets and Splits