Split (2)

train · 59.3M rows

text stringlengths 37 951k
गया. आठ ग्राम वाली गिन्नी 26,400 रुपये प्रति इकाई के पहले के स्तर पर रही. हालांकि अंतर्राष्ट्रीय बाजार में सोना मामूली बढ़कर 1295.50 डॉलर प्रति औंस पर रहा जबकि चांदी बढ़त के साथ 15.13 डॉलर प्रति औंस पर रही. मनरेगा से तालाबों को मिला नया जीवन उधर बताया गया कि मांझा मीरापुर द्वाबा के अभिलेख हाईकोर्ट के आदेश से सील किए गए हैं। इसी के चलते फिलहाल निरीक्षण कार्य स्थगित कर दिया गया है। चैत्र मास की शुक्ल पक्ष में पड़ने वाली एकादशी को कामदा एकादशी कहा जाता है। आज 7 अप्रैल के दिन यह शुभ घड़ी है। परिवारों को मुआवजा, नौकरी की मांग सवाल : कोरोना के बाद लगी पूर्णबंदी का फिल्मजगत पर काफी असर हुआ है। आप पर क्या असर हो रहा है? ससुर को पता ही नहीं, अब दामाद नहीं रहे ताज के रेड जोन (स्मारक परिसर) में सीआइएसएफ और यलो जोन (500 मीटर की परिधि) में पुलिस सुरक्षा व्यवस्था संभालती है। ताज के 500 मीटर के दायरे में ड्रोन उड़ाना प्रतिबंधित है। इसके बावजूद यहां सैलानी जानकारी के अभाव में ड्रोन उड़ा देते हैं। दुष्कर्म के दोषी को दस वर्ष के कारावास की सजा हसनपुर। गुरुवार रात आई आंधी और बारिश से जगहजगह विद्युत पोल टूटकर</s>
# Задание 2 # Опишите классы графического объекта, прямоугольника и объекта, который может обрабатывать # нажатия мыши. Опишите класс кнопки. Создайте объект кнопки и обычного прямоугольника. Вызовите # метод нажатия на кнопку. class Rectangle: left_down = [100, 50] right_up = [250, 175] class Click(Rectangle): def __init__(self, x_new, y_new): self.x = x_new self.y = y_new def do_click(self): if self.left_down[0] < self.x < self.right_up[0] and \ self.left_down[1] < self.y < self.right_up[1]: print('You hit the rectangle with click') else: print('You missed the target with a click') while True: print('Where do you want to click?') x = int(input('Enter coordinate x: ')) y = int(input('Enter coordinate y: ')) click = Click(x, y) click.do_click() again = input('Do you want to try again (Yes/No)?') if not again.lower() in ['yes', 'y']: break
Top Fixes To Put Your Thesis On Track People go through struggles with their dissertations at different phases of writing it. From generating the idea to the process of handing it over to the supervisors, it may be a daunting task to many students. Whenever you feel like you are putting up a struggle, be aware that you are not alone. Several hundreds of thousands have walked the same path as you and have made it. The grapples are standard, and your goals are achievable. The essence of a dissertation is to answer a question. - Identify your research question and recap it. Most advisors want to see this first. Make sure your research question is simple but informative. What is its motive, and what are you trying to answer? - What to do if you are stuck at the beginning The best way to start your dissertation is through reading. It will help you in getting your ideas flowing seamlessly. You will have ideas of what got discussed in your topic’s area and the issues that surround it. - What to do if you lack what to say If you find yourself backed in this corner, do thorough research. Look for arguments, patterns, or themes through other people’s work that may spark great discussions. - Let your instincts lead you Studies have shown that 90% of the time, people are always right when they trust their gut. If you feel something catches your attention or you have an interest in it, go with it. As you go through the reading process, make sure you note down things that catch your attention. - Write down all information you find Have a stack of index cards to help you take down short notes while reading. They are easier to handle and move around than notebooks. With this at hand, write everything down because your memory may fail you, as you may painfully try to remember a small detail but fail to find it. - What to do if you hit a dead-end If you are struggling, make it a habit of working every day, weekends included. It will help you stay on track with your work. It is easy to pick up from where you left if it was soon as yesterday. Getting back to a task you have stopped for a week or so will be confusing. - What to do if you are lagging Go to your advisor and discuss this issue to have options. Assess the situation and see if you can compensate for the lost time by adding a few extra hours every day. You can vent for a time extension. - What to do if you feel you have a terrible idea If you put too much time on a project, you will start doubting your work. Your work gets done when it is more right than wrong. Remember that you don’t need to be perfect. The examiners will give you suggestions, in the long run, no matter how brilliant your topic might be. However, to make your thesis paper better, feel free to reach out a professional coursework writing service and find the help you need. - What to do if your idea is not viable You will need to account for your project and develop a different approach. You should know that most academic works go hand in hand with other people’s work. Someone somewhere is always looking for answers to the same questions you are asking. If you find yourself in this situation, reach out and contact the owner.
साउथ एमसीडी के हाउस टैक्स दोगुना किए जाने के खिलाफ कांग्रेस ने आंदोलन की धमकी दी है। कांग्रेस के पूर्व विधायक मुकेश शर्मा ने बुधवार को आरोप लगाया है कि साउथ एमसीडी ने अपने इलाके में हाउस टैक्स दोगुना कर दिया है, इससे जनता में काफी रोष है, अगर साउथ एमसीडी ने इसे वापस नहीं लिया वो इसके खिलाफ सड़कों पर उतरेंगे, सड़क जाम कर देंगे। बुधवार को एक प्रेस कांफ्रेंस कर कांग्रेस के पूर्व विधायक मुकेश शर्मा ने यह जानकारी दी। उन्होंने कहा कि जिन संपत्तियों में किराएदार हैं उनमें सीधा हाउस टैक्स दोगुना करने का आदेश जारी हो गया है। उन्होंने कहा कि साउथ एमसीडी में सैकड़ों अनधिकृत कॉलोनियां और शहरीकृत गांव इससे प्रभावित होंगे। वहां के लोग एमसीडी के इस फैसले से गुस्से में हैं। मुकेश ने कहा कि इन इलाकों में लोगों को साउथ एमसीडी की तरफ से लोगों को बाकायदा नोटिस जारी किया जा रहा है। उन्हें डर दिखा कर वसूली की जा रही है। मुकेश शर्मा ने यह भी आरोप लगाया कि एमसीडी के इस फैसले को दिल्ली सरकार की भी अनुमति है। क्योंकि दिल्ली सरकार का शहरी विकास मंत्रालय सीधे तौर पर एमसीडी के प्रस्ताव को देखता है। कांग्रेस में गुटबाजी चरम पर! प्रदेश कांग्रेस में गुटबाजी चरम पर पहुंच चुकी है। जनहित के मुद्दे पर भी खुलकर गुटबाजी हो रही है। कांग्रेस के पूर्व विधायक ने साउथ एमसीडी द्वारा हाउस टैक्स बढ़ाए जाने के खिलाफ आंदोलन करने की सूचना मीडियाकर्मियों को मंगलवार को दी थी। जैसे ही इसकी सूचना प्रदेश कांग्रेस को लगी उन्होंने भी गुरुवार को इस मुद्दे को लेकर प्रेस कांफ्रेंस की घोषणा की। लेकिन मुकेश शर्मा के आंदोलन के एलान के बाद बुधवार की शाम को प्रदेश कांग्रेस ने अपनी प्रेस कांफ्रेंस रद्द कर दी। सूत्रों का कहना है कि जनहित के मुद्दे पर भी कांग्रेस के लोग साथ चलने को तैयार नहीं है। जबकि अभी कांग्रेस को अपनी जमीं फिर से बेहतर करने के लिए एक साथ मिलकर बीजेपी और आप के खिलाफ सड़कों पर उतरना चाहिए था।
Spiced Parsnip Cupcakes Recipe Dean Edwards, TV chef and ex Masterchef finalist, gets cooking with whole grains and shares a great recipe using vegetables in baking Cost Per Serving Nutrition Per Serving - Calories350 kcal Calories are a measure of the amount of energy in food and drink. Your weight depends on the balance between how much energy you consume and how much energy you use up. If you eat or drink more than you use you can gain weight. If you don’t eat enough you can lose it. Your body wouldn’t function without fat. Fat is an essential part of a healthy balanced diet. It provides fat soluble vitamins and essential fatty acids. But as fat is a rich source of energy (calories), it can easily contribute to weight gain. On average as a nation it seems we’re consuming too much saturated fat. Eating too much can increase your cholesterol, which is a risk factor for heart disease. Replacing saturated fats with unsaturated fats can help maintain healthy cholesterol levels, and reduce the risk of heart disease. Starchy foods like bread, breakfast cereals or potatoes are a good source of carbohydrate and should make up just over a third of the food you eat. When eaten, carbohydrates are broken down into glucose, which is used to fuel cells in your body like brain and muscle cells. Some people think starchy carbohydrates are fattening, but gram for gram it contains less than half the calories of fat. Choose whole grain or high fibre varieties where you can as they often contain more nutrients. On average in the UK we eat too much sugar. Foods and drinks high in sugars are not needed in the diet. So if you have them, make sure they're infrequent and in small amounts, or you risk tooth decay or obesity. Fibre is classed as a carbohydrate and you should aim to eat 30g fibre each day. Eating plenty of fibre is good for your digestive health and is associated with a lower risk of heart disease, stroke, type 2 diabetes and some cancers. All cells and tissues contain protein, so it’s essential for growth, repair and good health. Protein from animal sources such as meat, fish, eggs and dairy products contain all the essential amino acids (the building blocks of protein) needed by the body. If you're vegetarian or vegan, you can get the protein you need through eating a variety of different plant sources such as pulses, nuts and cereals. A small amount of salt is needed in your diet but too much can raise your blood pressure, which increases risk of health problems such as heart disease and stroke. Adults shouldn’t eat more than about 1 teaspoon (6g) per day – and that includes salt already in the foods you eat, not just the salt you add, so check nutrition labels on food packs. Thanks for rating. Now leave a tip or review - Preheat the oven to 180°C, 160°C fan or gas mark 4. Line a 12-hole muffin tin with paper cake cases. - Whisk the butter and sugar together until pale and fluffy, then beat in the eggs, one at a time. - Tip in the flour, mixed spice and baking powder and mix them in. Stir in the milk and then the grated parsnip. - Spoon the mixture into the cake cases until about 2/3 full and bake for 20-30 minutes, or until golden and cooked through. Allow to cool slightly in the tin, then take them out and cool completely on a wire rack. - Blend the cream cheese with icing sugar, to taste. Put the mixture into a piping bag fitted with a small star nozzle and pipe it on top of the cakes (or spread the mixture on the top of the cakes with a palette knife). - Garnish each cupcake with a little fresh lemon thyme or mint, then serve. - Increase the number of muffins you make to 15 or 16 to improve nutrition - To reduce fat and saturated fat content use reduced fat cream cheese
The world’s first application of subsea LiDAR data used to 3D Print an accurate 1:1 physical model of a damaged well part has been announced by Fugro and 3D at Depth, a global provider of advanced subsea LiDAR systems and solutions. The ability to use accurate spatial data in subsea part fabrication with 3D printing, introduces a wide range of possibilities to reduce costs across intervention planning and Life of Field programs. The subsea part fabrication was part of a larger project conducted in early 2016, using 3D at Depth’s subsea LiDAR SL 2 technology and point cloud software. Project Has Cost Effective Implications Across Life of Field Programs and Intervention Planning 3D at Depth was contracted by Fugro to perform subsea laser scanning services on a well abandonment project in Oceania, Australia. The Plugged and Abandoned (P&A) wells located in a water depth of circa 110 meters, were drilled decades earlier and suspended at the time of drilling. Access to accurate data of the manufacture and specifications of these wellheads was limited due to their age. In order to assess feasible options for abandonment, detailed measurements needed to be acquired to achieve final abandoned status. The survey used Fugro’s multi-role intervention vessel, the “Rem Etive” fitted with two work class remotely operated vehicles (ROVs). One of the two FCV Work Class ROVs, of 3000m depth rating, was fitted with an SL2 Subsea LiDAR laser, manufactured and operated by 3D at Depth. The laser was mounted on the crash bar of the Fugro FCV3000 WROV sending near real-time data to the operator on the vessel via a fibre optic multiplexor. Subsea LiDAR Data Collection Approximately 44 million data points were collected at the well in 13.5 hours. The LiDAR laser data was processed using point cloud processing tools to compute the spatial relationships, measurements and orientations of the seabed structures. The resulting deliverables included a 3D point cloud database, a dimensional report for each well, CAD files and a 360° animation of each well, modelled from the point cloud. In addition to subsea LiDAR data, physical measurements were collected by the Fugro ROV using different sizes of V-gauges and rulers. Cross-referencing of the physical and LiDAR measurements with the original drawings helped identify discrepancies in existing drawing dimensions. 3D Print Process (Additive Manufacturing) To create a 1:1 model for the design of an appropriate ‘hot tap’ connector, a 3D print of the top of the well, with its damaged stub, at full scale was required. As the large size of the well cap structure made the cost prohibitive, a hybrid Computer Numeric Control (CNC) machining process, combined with a 3D print of the damaged part, was proposed by 3D at Depth as a viable alternative solution. The first step was to re-processes the point cloud data from the top of the well and then create 3D CAD models of the separate parts. However, this process proved more challenging than first thought due to the complexity of the shape. For this particular part the auto meshing algorithms which convert point clouds into surfaces did not perform well and as a result the CAD model was developed manually, which is also common when modelling complex shapes from terrestrial laser scans. The part was then 3D printed by means of Fused Deposition Modelling (FDM) technology using Acrylonitrile Butadiene Styrene (ABS) thermoplastic material. One of the other two CNC machined parts was made from Acetal and the well cap from ultra-high-molecular-weight polyethylene (UHMWPE). “While the individual sector scans provide millimeter accuracies, the wide area point cloud can provide a 3D dataset of centimeter accuracy across an entire drill center,” confirms Adam Lowry, MD of 3D at Depth Pty Ltd. “Wide area point clouds, when used for planning, have proven to avoid costly surprises which are otherwise only discovered after the intervention vessel is actually on location. Cost savings can be realised from almost any situation where accurate spatial data would be beneficial to planning intervention operations.” 3D at Depth was the first company to commercialize subsea LiDAR technology for oil and gas offshore hydrocarbon extraction. Today, 3D at Depth Subsea LiDAR data is used across a wide range of applications including subsea metrology and complex metrology, IMR planning, as-built surveys, dimensional control surveys, pipeline damage, pipeline curvature, scour quantification, subsea structure movement, scientific seafloor mapping and investigations, historic preservation, and offshore wind farms.
In 1987, Ullah et al. published a paper about a simple and novel granulation process called moisture-activated dry granulation (MADG) (1). In this granulation process, a small amount of water is used to activate the granule formation (i.e., perform agglomeration) without requiring hot air drying of the granules. After creating the moist agglomerates, this process uses stepwise addition and blending of common pharmaceutical ingredients that absorb and distribute moisture, thus resulting in a uniform, free-flowing, and compactible granulation. In 1990, Chen published a study comparing the MADG process with the conventional granulation processes for sematilide hydrochloride tablets (2). Although the active pharmaceutical ingredient (API) in the formulation was cohesive and fluffy, the granulation made with the MADG process was generally comparable with that made through the wet-granulation and roller-compaction processes. In addition, the authors found that MADG was not only a shorter process, but that the final granulation made with the MADG process showed superior flowability and better tablet-content uniformity. In 1994, Christensen employed the MADG process to successfully make pharmaceutical granulations with micro crystalline cellulose, potato starch, and both of these excipients (3). The knowledge that the pharmaceutical industry has gained during the past several years about excipients used for solid dosage forms, the associated granulation equipment, and the manufacturing processes has fostered the acceptance of the MADG formulation process. The authors previously provided a roadmap for selecting excipients and equipment for the MADG process (4). They also described a step-by-step procedure for MADG-based formulation development.This article evaluates the effects of the formulation and process variables on the MADG process, provides examples of the MADG formulation-development and manufacturing processes, and introduces existing and new pharmaceutical excipients that are well-suited for the MADG process. This article also highlights the advantages and wide applicability of the MADG process in solid dosage form formulation development. Active pharmaceutical ingredients. Acetaminophen USP (Rhodia, Cranbury, NJ) and Compounds A, B, C, D (Bristol-Myers Squibb, BMS, New York) were used. At room temperature, the ingredients' water solubility ranged from slightly soluble to practically insoluble. Their particle size (d90) ranged from <20 μm to <200 μm. Excipients. The authors used lactose monohydrate NF (Sheffield Pharma Ingredients, New York), mannitol USP (Pearlitol 160 C, Roquette America, Keokuk, IA), povidone USP (PVP K-12, International Specialty Products, ISP, Wayne, NJ), hydroxypropyl cellulose NF (HPC EXF, Hercules, Wilmington, DE), copovidone NF (BASF Ludwigshafen, Germany), maltodextrin NF (Maltrin 180, Grain Processing, Muscatine, IA), microcrystalline cellulose NF (Avicel PH200 Low Moisture, FMC BioPolymer, Philadelphia); microcrystalline cellulose NF (Avicel PH102, FMC BioPolymer), silicon dioxide NF (Aeroperl 300, Evonik Degussa, Essen, Germany), crospovidone NF (ISP), and magnesium stearate NF (Mallinckrodt, Hazelwood, MO). Manufacturing equipment. High-shear granulators commonly used in the pharmaceutical industry were selected for the MADG process based on the experimental scale. Diosna P1/6 2 L (DIOSNA Dierks und Söhne, Germany) and Aeromatic-Fielder PMA 150 L (Hampshire, England) were used for 400-g and 30-kg batch sizes, respectively. The water-delivery system used for the granulation process was a digital gear pump (model 75111-30, Cole-Palmer, Vernon Hills, IL) equipped with a pressure nozzle (Düsen-Schlick, Coburg, Germany), or any atomization nozzles that can provide similar hollow-cone or flat-fan spray patterns. A Carver press (Carver, Wabash, IN) was used for pellet compaction. During the agglomeration stage, all or part of the API is mixed with fillers and a granulating binder to obtain a uniform mixture. During mixing, a small amount of water (1–4% of the weight of the entire formula) is sprayed onto the powder blend, thus enabling the water droplets to moisten the binder to make it moist and tacky. The API and excipient particles bind together as the mixer impellers or blades move them in a circular motion. The resulting agglomerates are small, spherelike granules with a typical particle size of 150–500 μm. In the next stage of the process, moisture absorbents such as microcrystalline cellulose or silicon dioxide are added while mixing continues. The entire mixture becomes drier as some of the water in the moist agglomerates is released to the moisture absorbents. The agglomerates remain largely intact during the moisture-distribution stage, although the larger particles often break up. Disintegrant is added to the mixture at this stage and blended. Then, while mixing continues, lubricant is added and blended for sufficient time to achieve adequate lubricity. This completes the MADG granulation process, which takes about 15 min.
विगत अनेक वर्षो से किसानो द्वारा समय समय पर सरकारो से अपनी समस्याओ का स्थायी समाधान निकालने की मांग की गई। किन्तु सरकारो द्वारा इसका स्थायी हल निकालने मे कोई रुचि नही दिखाई । दिनोदिन किसानो की परेशानी बढ़ती रही। पिछले कुछ समय से किसानो को कुछ उम्मीद बनी कि, अब शायद उसकी समस्याए समाप्त होगी किन्तु जब यह उम्मीद टूटने लगी तो देश के किसानो मे आक्रोश फैला। अभी हाल ही मे कृषि उत्पाद के दाम समर्थन मूल्य से नीचे आ गए, सरकार द्वारा खरीद कि पर्याप्त व्यवस्था नही थी, भुगतान भी नही हो रहा था। ऐसे अनेकों कारणो से किसान आंदोलन के लिए उद्वेलित हुये। इन सब बातो को देखते हुये भारतीय किसान संघ ने भी कई प्रांतो मे आंदोलन शुरू किए। लेकिन भारतीय किसान संघ का यह सिद्धान्त है कि, हम हमेशा देशहित का ध्यान पहले रखेंगे। आंदोलन शांतिपूर्ण रहेगा, उसमे हिंसा नही होने देंगे तथा कार्यकर्ता पूर्ण अनुशासन मे रहेंगे। लेकिन आंदोलन मे मालवा मे जब हमारे आंदोलन मे कुछ बाहरी तत्व शामिल होकर हिंसा फैलाने कि जानकारी हुई तथा उसी समय सरकार द्वारा क्षेत्रीय मांगो को मान्य कर लिया गया, तब आंदोलन वापस लिया गया। हमे प्राप्त सूचना सच साबित हुई तथा उन तत्वो द्वारा हिंसा फैलाने का प्रयास किया गया। तमिलनाडू, महाराष्ट्र, राजस्थान मे भी आंदोलन हुये। राजस्थान मे भारतीय किसान संघ द्वारा किया गया आंदोलन भी अनुशासनबद्ध और अहिंसक रहा किन्तु स्वरूप बड़ा होने से अंत मे सरकार को झुकना पड़ा तथा किसानो कि सभी मांगे मान ली गई।इसके बावजूद अभी भी किसानो मे बहुत आक्रोश व्याप्त है। इस पर हम सतत विचार कर रहे है। भारतीय किसान संघ कि स्थापना से ही यह मान्यता रही है कि, किसान को उसकी उत्पाद का लागत मूल्य तथा उस पर लाभांश जोड़कर लाभकारी मूल्य प्राप्त होना चाहिए। लेकिन दुर्भाग्य से देश मे कई सरकारे आने जाने के बाद भी अभी तक लाभकारी मूल्य प्राप्त नही हो सका। देश मे कृषि उत्पाद आयात निर्यात कि अब तक कोई ठोस नीति नही बन सकी। लिसके अभाव मे कृषि उत्पाद का जो आयात निर्यात होता है उसमे किसान हित को कोई महत्व नही दिया जाता है। जिसका परिणाम यह होता है कि बम्पर फसल आने के बावजूद या तो निर्यात प्रतिबन्धित किया जाता है या आयात किया जाता है। दोनों ही परिस्थितियो मे कृषि उत्पाद के मूल्य धराशायी हो जाते है और किसान ठगा सा रह जाता है। इस वर्ष ऐसा ही दलहन के मामले मे हुआ। किसान के उत्पादन का सरकार द्वारा घोषित समर्थन मूल्य से बाज़ार मे जब उक्त उत्पाद का दाम कम होता है तब उसकी पूर्ति के लिए सरकार द्वारा एक मूल्य स्थिरीकरण कोष बनाकर, भावांतर योजना तत्काल लागू कि जाए। जैसा कि मध्य प्रदेश एवं आंधप्रदेश मे किया गया है। खाद्य प्रसंस्करण, पशुपालन एवं डेरी आदि को बढ़ावा देकर गावों से होने वाले पलायन को रोका जा सकता है। जिससे ग्रामीण युवाओ को रोजगार के अवसर, गावों मे ही उपलब्ध होंगे और नशे एवं अपराधो पर भी अंकुश लगेगा। ऐसी गंभीर परिस्थिति मे सरकार को हड़बड़ाहट मे कर्जमाफ़ी का निर्णय न लेकर, देश के सभी किसानो को प्रति एकड़ एक निश्चित राशि तय कर सीधे उनके खाते मे जमा करने कि योजना बनाकर उसे तत्काल लागू करना चाहिए। उपरोक्त सभी बिन्दुओ को ध्यान मे रखते हुए केंद्र एवं राज्य सरकारे संसद एवं विधान सभाओ का विशेष सत्र बुलाकर, किसान संगठनो का सहयोग लेकर, राजनैतिक मतभेद भूलकर, भारत एक कृषि प्रधान देश है इस वाक्य को चरितार्थ करने के लिए, कृषि क्षेत्र के लिए समग्र कृषि रोड मैप तैयार करे। तभी किसान कि समस्याओ का स्थायी समाधान हो सकेगा।
That no free government, or the blessing of liberty, can be preserved to any people but by a firm adherence to justice, moderation, temperance, frugality, and virtue, and by frequent recurrence to fundamental principles. Topics: Liberty, Government Wondering Whom to Read Next? - James Madison American Statesman, President - Thomas Jefferson American Head of State - John Marshall American Judge - George Washington American Head of State - Martha Washington American First Lady - Robert E. Lee American Military General - John Randolph American Politician - Jane Addams American Social Reformer - Charles Mingus American Jazz Bassist, Composer - Raymond Chandler American Novelist
फाइनेंशियल टाइम्स की खबर के अनुसार प्रधानमंत्री बोरिस जॉनसन की सरकार एक घरेलू कानून की योजना बना रही है जो उत्तरी आयरलैंड के ब्रिटिश क्षेत्र और यूरोपीय संघ के सदस्य आयरलैंड के बीच खुली सीमा बनाए रखने की प्रतिबद्धताओं को कमतर करने से संबंधित है। 1481 ग्रेगोरी कैलंडर का एक साधारण वर्ष है। अभियोजक ने ब्रिटेन की इस अदालत को बताया कि सउदी अरब में समलैंगिकता अवैध है और इस आरोप में मौत की सजा भी हो सकती है। (भाषा) इसलाम. नहीं हुआ तो न्यायालय का लेंगे सहारा कोरोना महामारी की दूसरी लहर के कमज़ोर पड़ने के साथ ही एक और अच्छी ख़बर इस वक़्त में आई है। ख़बर यह है कि ड्रंग कंट्रोलर जनरल ऑफ़ इंडिया (डीसीजीआई) ने शुक्रवार को सीरम इंस्टीट्यूट ऑफ़ इंडिया को भारत में रूस की वैक्सीन स्पुतनिक बनाने की अनुमति दे दी है। यह तीसरी वैक्सीन होगी, जो भारत में बनाई जाएगी। खुद के साथ की थी पूल पार्टी पिछले साल बॉलीवुड एक्ट्रेस सुष्मिता सेन ने अपने ब्वॉयफ्रेंड रितिक भसीन से ब्रेकअप कर लिया। वे दोनों पिछले चार सालों से एक दूसरे को डेट कर रहे थे। बताया जाता है कि इतने कम वक्त में ही दोनों का रिश्ता कई बार टूटने की कगार पर</s>
Many human cancers, particularly gliomas and acute myelogenous leukemia (AML), contain mutations in the genes IDH1 or IDH2, which encode two isoforms of the metabolic enzyme isocitrate dehydrogenase (1, 2). These mutant enzymes produce the (R)-enantiomer of 2-hydroxyglutaric acid [(R)-2HG], a molecule that inhibits histone- and DNA-modifying enzymes, thereby altering gene expression and promoting the acquisition of malignant features (3–5). Reports by Losman et al. (6) as well as by Wang et al. (7) and Rohle et al. (8) on pages 622 and 626 of this issue, respectively, find that inhibitors of the mutant forms of IDH1/2 suppress the growth of (R)-2HG–producing tumor cells (6–8). The findings imply that curtailing (R)-2HG supply normalizes gene expression and reverses malignancy.
भी हुई थी। खतरों के खिलाड़ी में कई बार कंटेस्टेंट टास्क के दौरान घायल हो जाते हैं। तबेले में सोया था युवक, बदमाशों ने चाकू से गोदकर किया घायल, मारी गोली जानकारी के अनुसार जैसलमेर सदर पुलिस थाने में तैनात कांस्टेबल आत्माराम की फेसबुक आईडी हैक हो गई है। हैकर ने उसकी फेसबुक प्रोफोइल में नाम बदलकर एलेक्स मोर्गन कर दिया है। इसके साथ ही उसे कमांडो बताया गया है। फेसबुक आईडी में उसका पता बदलकर अफगानिस्तान के काबुल का निवासी बताया है। गौरतलब है कि राजस्थान के सीमावर्ती इलाके जैसलमेर में लोगों की फेसबुक आईडी हैक किए जाने का सप्ताहभर में यह दूसरा मामला है। कांस्टेबल से पहले एक युवक की आईडी हैक कर ली गई थी। भीख मांगकर कर रहे गुजारा बता दे की पूर्व में मुंबई की बांद्रा कोर्ट में अरबाज व मलाइका का तलाक हो चूका है तथा अब यह दोनों ही अलग अलग रह रहे है. दोनों को तलाक आपसी मंजूरी पर दिया गया है. अब मलाइका के साथ में अपने सारे रिश्ते नाते तोड़ने के बाद अब एक बार फिर से अरबाज की पूर्व पत्नी मलाइका अरोरा सुर्खियों में चल रही है. बीजेपी और शिवसेना के रिश्तों को लेकर भी कई कार्टून बनाए गए</s>
Not a member yet? Join now Whichever way the vote goes, today is a historic day for Britain and for the EU. Let's cast an InterNations vote and see what we think it may happen. R=RemainL=Leave I bet on remain, so the score is Protected content . Cast your vote, add it to the previous score and write the total. Let's vote! :) PS: If what you THINK will happen is different from what you WANT to happen, please vote for what you WANT to happen. This way we may get a more accurate result.
The information below pertains only to real property as opposed to personal property. As a property owner, you should be diligent in regard to your property and finances. What follows is important information provided by the FB All parties to a real estate transaction are potential targets of wire fraud and may lose hundreds of thousands of dollars because they simply relied on the wire instructions received via email, without further verification. If funds are to be wired in conjunction with this real estate transaction, it is strongly recommended that verbal verification of wire instructions, through a known trusted phone number made prior to sending funds. - Never rely on emails purporting to change wire instructions. Parties to a transaction rarely change wire instructions in the course of a transaction. - Always Verify wire instructions, specifically the routing number and account number, by calling the party who sent the instructions to you. Do not use the phone number provided in the email containing the instructions, use phone numbers you have called before or can otherwise verify. Obtain the phone number of relevant parties to the transaction as soon as an escrow account is opened. Do not send an email to verify as the email address may be incorrect or the email may be intercepted by the fraudster. - Use complex email passwords that employ a combination of mixed case, numbers, and symbols. Make your passwords greater than eight (8) characters. Also, change your password often and do NOT reuse the same password for other online accounts. - Use multi-factor authentication for email accounts. Your email provider, or IT staff, may have specific instructions on how to implement this feature. This is a type of Financial institution fraud and is characterized by some type of material misstatement, misrepresentation, or omission in relation to a mortgage loan which is then relied upon by a lender. A lie that influences a bank’s decision about whether, for example, to approve a loan, accept a reduced payoff amount, or agree to certain repayment terms is mortgage fraud. There are two distinct areas of mortgage fraud. Fraud for profit: Those who commit this type of mortgage fraud are often industry insiders using their specialized knowledge or authority to commit or facilitate the fraud. Fraud for profit aims not to secure housing, but rather to misuse the mortgage lending process to steal cash and equity from lenders or homeowners. Fraud for housing: This type of fraud is typically represented by illegal actions taken by a borrower motivated to acquire or maintain ownership of a house. The borrower may, for example, misrepresent income and asset information on a loan application or entice an appraiser to manipulate a property’s appraised value. Common Examples of mortgage fraud. - Title Transfer: The most dangerous scheme is the “bailout” that never quite works. This scenario includes various schemes in which the homeowner surrenders title to the house in the belief that within the deal, they’ll be able to remain in the home as a renter, and eventually buy it back. Homeowners are sometimes told that surrendering title is necessary so that someone with a better credit rating can secure new financing to prevent the loss of the home. But the terms of these deals are almost invariably so onerous that the buyback becomes impossible, the homeowner loses possession permanently, and the “rescuers” end up with all or most of the home’s equity, often evicting the original homeowner. Another scam convinces the homeowner to transfer title to a “federal land grant” with the false promise that this prevents the lender from foreclosing. - Foreclosure rescue schemes: The perpetrators identify homeowners who are in foreclosure or at risk of defaulting on their mortgage loan and then mislead them into believing they can save their homes by transferring the deed or putting the property in the name of an investor. The perpetrators profit by selling the property to an investor or straw borrower, creating equity using a fraudulent appraisal, and stealing the seller proceeds or fees paid by the homeowners. The homeowners are sometimes told they can pay rent for at least a year and repurchase the property once their credit has been reestablished. However, the perpetrators fail to make the mortgage payments and usually the property goes into foreclosure. - Loan modification schemes: Similar to foreclosure rescue scams, these schemes involve perpetrators purporting to assist homeowners who are delinquent in their mortgage payments and are on the verge of losing their home by offering to renegotiate the terms of the homeowners’ loan with the lender. The scammers, however, demand large fees up front and often negotiate unfavorable terms for the clients, or do not negotiate at all. Usually, the homeowners ultimately lose their homes. - Equity skimming: An investor may use a straw buyer, false income documents, and false credit reports to obtain a mortgage loan in the straw buyer’s name. Subsequent to closing, the straw buyer signs the property over to the investor in a quit claim deed, which relinquishes all rights to the property and provides no guaranty to title. The investor does not make any mortgage payments and rents the property until foreclosure takes place several months later. - Silent second: The buyer of a property borrows the down payment from the seller through the issuance of a non-disclosed second mortgage. The primary lender believes the borrower has invested his own money in the down payment, when in fact, it is borrowed. The second mortgage may not be recorded to further conceal its status from the primary lender. - Home equity conversion mortgage (HECM): A HECM is a reverse mortgage loan product insured by the Federal Housing Administration to borrowers who are 62 years or older, own their own property (or have a small mortgage balance), occupy the property as their primary residence, and participate in HECM counseling. It provides homeowners access to equity in their homes, usually in a lump sum payment. Perpetrators taking advantage of the HECM program recruit seniors through local churches, investment seminars, and television, radio, billboard, and mailer advertisements. The scammers then obtain a HECM in the name of the recruited homeowner to convert equity in the homes into cash. The scammers keep the cash and pay a fee to the senior citizen or take the full amount unbeknownst to the senior citizen. No loan payment or repayment is required until the borrower no longer uses the house as a primary residence. In the scheme, the appraisals on the home are vastly inflated and the lender does not detect the fraud until the homeowner dies and the true value of the property is discovered. - Commercial real estate loans: Owners of distressed commercial real estate (or those acting on their behalf) obtain financing by manipulating the property’s appraised value. Bogus leases may be created to exaggerate the building’s profitability, thus inflating the value as determined using the ‘income method’ for property valuation. Fraudulent appraisals trick lenders into extending loans to the owner. As cash flows are lower than stated, the borrower struggles to maintain the property and repairs are neglected. By the time the commercial loans are in default, the lender is often left with dilapidated or difficult-to-rent commercial property. Many of the methods of committing mortgage fraud that are found in residential real estate are also present in commercial loan fraud. Signs for Real Estate Fraud: Anyone can be vulnerable to real estate fraud and identity theft, however, the elderly and economically challenged traditionally have been targeted. Below are some common warning signs of real estate fraud: - You receive official documents indicating a transfer of your property and you have no knowledge of the transaction; - You did not receive a property tax bill. This can be the first sign of fraud; and - You receive mortgage documents or payment books for loans for which you never applied. Please see our other related articles Disclaimer: Every situation is different and particular facts may vary thereby changing or altering a possible course of action or conclusion. The information contained herein is intended to be general in nature as laws vary between federal, state, counties, and municipalities and therefore may not apply to any given matter. This information is not intended to be legal advice or relied upon as a legal opinion, course of action, accounting, tax or other professional service. You should consult the proper legal or professional advisor knowledgeable in the area that pertains to your particular situation.
Medical Definition of Diastrophic dysplasia Diastrophic dysplasia: An inherited skeletal disorder involving significantly short stature (dwarfism). Characteristic features at birth include short birth length with short limbs (short-limbed dwarfism), "hitchhiker thumb", and clubfeet. Palatal malformations such as cleft palate or submucous cleft of the palate are present in 50% of patients. There is swelling of the ears in the first days to weeks of life in 80% of children; the swelling then spontaneously subsides but later the ears have a "cauliflower" appearance. Fingers are short and broad and show ulnar deviation (are inclined away from the thumb). The thumb itself has a hitch-hiker-type appearance. There is increased death rate in infancy due to problems breathing, but thereafter people with diastrophic dysplasia have a normal life span. Orthopedic problems are common. The joints can be dislocated, especially the shoulder, elbows, hips, and patellae (knee caps). Flexion contractures of the knees and shoulders are common. Scoliosis (sideways curvature of the spine) is not present at birth but often develops and is progresses particularly in the early teen years. Treatment of the scoliosis includes bracing and occasionally, spinal fusion. Progressive kyphosis (forward bending of the spine) can also occur with what is called subluxation (slippage) which can result in compression of the spinal cord. The average length of babies with diastrophic dysplasia at birth is 16 1/2 inches (42 cms). The average adult height is slightly under 4 feet -- 46-47 inches (118 cms) to be exact. The final adult height is influenced by the presence of scoliosis, hip contractures and knee contractures, and foot deformities. Diastrophic dysplasia is inherited as an autosomal recessive condition meaning that the gene for diastrophic dysplasia is on one of the nonsex chromosomes and average-sized parents have a 1 in 4 (25%) chance of having additional children with diastrophic dysplasia. The gene for diastrophic dysplasia is on chromosome 5q32-q33.1 and is called "diastrophic dysplasia sulfate transporter" (DTDST). Prenatal diagnosis has been performed for diastrophic dysplasia by ultrasound and by molecular DNA diagnosis to detect DTDST. Diastrophic dysplasia was first clearly delineated by Maroteaux and Lamy in France in 1960. The term "diastrophic" was borrowed by Lamy and Maroteaux from geology: diastrophism is the process of bending of the earth's crust by which mountains, continents, ocean basins, etc., are formed. Dysplasia means abnormal in form.Source: MedTerms™ Medical Dictionary Last Editorial Review: 6/9/2016 Medical Dictionary Definitions A - Z Search Medical Dictionary
: Deep vein thrombosis (DVT), a frequent complication of spinal cord injury, is occasionally caused by neurogenic heterotopic ossification (NHO). In most cases of NHO, the hip joint is affected. Herein, we present a case of paraplegia following radiation-induced myelopathy that presented with left leg swelling due to DVT in the common iliac vein (CIV) caused by venous compression by NHO on the anterior lower lumbar spine. : A 28-year-old man with complete paraplegia due to radiation-induced myelopathy presented with left lower extremity swelling 6 years after the onset of paraplegia. DVT in the left CIV was observed on computed tomography venography. The left CIV was significantly compressed between the NHO at the anterior longitudinal ligament of the lumbar spine and the right common iliac artery, suggestive of May-Thurner syndrome. Slightly distal to that compressed area, the left CIV was significantly compressed by the large NHO at the anterior longitudinal ligament of the lumbar spine. : We believe that such compression of the left CIV would have contributed to the development of DVT. This case shows that DVT might be caused by NHO at the anterior aspect of the lumbar vertebral body, and this may help clinicians identify the main cause of DVT in the leg.
Strengthening of Small Lebanese Economic Actors through a Range of Services Number of Beneficiaries: Integrating support for ecological transition and innovative and adapted financial products- Tarik Akhdar Nurturing Prosperity: Our project’s grand vision was to ignite a renaissance in Lebanon‘s rural and agricultural economy, championing responsible growth and sustainable approaches. Our tailored goals encompassed empowering cooperatives and micro-enterprises to embrace eco-friendly practices, while enhancing the capacities of FTL, FTTL, and Al Majmoua to amplify Fair Trade‘s reach and foster ecological and social transitions. A substantial impact awaits, benefiting over 1123 individuals, including 562 remarkable women, paving the way for a brighter future.
पटना। मैं तेरी दुनिया छोड़ चला मोबाइल पर यह गाना फुल साउंड में बजाकर अपने पॉकेट में रखा और गले में फंदा डालकर पेड़ से झूल गया। आत्महत्या करने का यह तरीका देखकर गांव वाले भी चकरा गए। लोगों ने युवक को देखा तो पेड़ से उतारा, तबतक उसकी मौत हो चुकी थी। घटना पटना के दुल्हिनबाजार की है, जहां शुक्रवार की देर शाम एक युवक ने एनएच-९८ के मुख्य पथ के किनारे स्थित एक पेड़ में फांसी का फंदा डालकर लटक गया और अपनी जान दे दी। लोगों ने इसकी सूचना पुलिस को दी, पुलिसशव जब्त कर मामले की जांच कर रही है। मिली जानकारी के मुताबिक मृतक युवक रानीतालाब थाना क्षेत्र के निसरपुरा गांव निवासी वंशी मांझी का पुत्र हरिया मांझी (३५) है। बताया जाता है कि युवक मंदबुद्धि था और हाल ही में उसकी शादी हुई थी। पत्नी को जब पता चला कि उसका पति मंदबुद्धि है तो वह उसे छोड़कर चली गई थी। युवक इसके बाद डिप्रेशन में रहता था। कल शाम वह घर से निकलकर चुपचाप सड़क के किनारे बैठा था और मोबाइल से गाना सुन रहा था। उसके बाद उसने मोबाइल पॉकेट में डाल पेड़ से लटककर अपनी जान दे दी। उसका शव संदिग्ध स्थिति में निसरपुरा चैनपुरा गांव के समीप पीपल के पेड़ से लटका मिला। पुलिस शव बरामद करने के बाद मामले की जांच कर रही है। परिजनों ने कोई लिखित शिकायत नहीं की है।
A Complete Guide to Install SSL certificate in Tomcat Server. Tomcat also knew as Apache tomcat is a well-renowned name in the network category. Its popularity lies in being an open source web server by Apache Software Foundation. It basically supports Java-based applications (Java server pages (JSP) and Java servlets) by being a pure Java HTTP web server. You should follow instructions to installing SSL certificate in Tomcat. Generating Certificate Signing Request (CSR): Before obtaining a Certificate from SSL2BUY, you need to create a CSR. With the help of this CSR, the CA will issue the certificate identifying your website as secured. Below are the steps given to creating a CSR: Local certificate creation: keytool -genkey -alias tomcat -keyalg RSA -keystore <your_keystore_filename> Note: In the few cases, you will have added the domain of your website (for e.g. www.yoursite.org) in the “first-and lastname” fields for creating a working certificate. Now, for creating the CSR, type the following command: keytool -certreq -keyalg RSA -alias tomcat -file certreq.csr -keystore <your_keystore_filename> Now you have a file named certreq.csr that you can present to the Certificate Authority. CA certification installation using X.509 format - Select proper primary and secondary intermediate certificate. - Copy-paste the contents of primary and secondary intermediate certificate in two separate text files, of course. Make sure that there are no white spaces, line breaks and extra lines in the file. - Name the primary intermediate certificate text file as primary-inter.cer - To import the above certificate into the keystore uses the following command keytool -import -trustcacerts -alias primaryIntermediate -keystore your_keystore_filename -file primary_inter.cer - Name the secondary intermediate certificate text file as secondary_inter.cer. - In order to import the certificate, use the following command into the keystore. keytool -import -trustcacerts -alias secondaryIntermediate -keystore your_keystore_filename -file secondary_inter.cer Install SSL certificate You have to download or copy-paste the certificate which you have received through e-mail. For the certificate which is emailed as an attachment, download and use it as it is. For the certificate which is forwarded as in text format; copy and paste it into a text file. Please do not use Microsoft Word for this purpose as it will enumerate extra characters. Also, make sure that there are no white spaces or extra lines in the file. It will look something like this: -----BEGIN CERTIFICATE----- [encoded data] -----END CERTIFICATE----- The five dashes after and before “Begin Certificate” & “End Certificate” are compulsory. There should be no white spaces, line breaks, and additional certificates. Type the command to import the SSL certificate as given below: Keytool -import -trustcacerts -alias your_alias_name -keystore your_keystore_filename -file your_certificate_filename Note: The alias name should not be different from that mentioned during the generation of the private key and CSR. Verify the contents of the Certificate To list the contents of the keystore please type the following command: keytool -list -v -keystore your_keystore_filename >output_filename You will be able to view the content of the output in the following manner: The SSL certificate should be imported under the alias “Entry Type” of PrivateKeyEntry or KeyEntry, if it is not so then please import it into the Private Key alias. To enable SSL configuration your server.xml file - Open the server.xml config file in the text editor. - Search for the secure element in your config file (try searching for SSL Connector). By default, it should look something like this: <-- SSL Connector on Port 8443 --> <!-- <Connector className="org.apache.coyote.tomcat4.CoyoteConnector" port="8443" minProcessors="5" maxProcessors="75" enableLookups="false" acceptCount="10" connectionTimeout="60000" debug="0" scheme="https" secure="true"> <Factory className="org.apache.coyote.tomcat4.CoyoteServerSocketFactory" clientAuth="false" protocol="TLS" keystoreFile="insert path to the keystore here"> keystorePass="insert keystore password here"> </Connector> --> - Make sure the “keystoreFile” directive is citing the correct keystore and the “keystorePass” directive is addressing the correct keystore password. NOTE: These directives are case-sensitive! Make sure the letters “F” and “P” in “keystoreFile” and “keystorePass” are in upper case. - If your keystore contains more than one private key alias, please add the “keyAlias” directive to reference the correct private key alias name. keystoreFile=”insert path to the keystore here” keystorePass=”insert keystore password here” keyAlias=”insert private key alias here”/> - Save the changes. - Stop and Restart Tomcat In order to verify the contents of the certificate, use the installation checker. For further information, please refer to the Tomcat Web site.
Design of Intelligent Thin-Walled Composite Beams This paper reports a further study on the design of intelligent thin-walled composite beams using piezoelectric materials to actively control their transient vibrations. A theorem of sensibility is proved to establish the sensibility of modal vibration by distributed sensors. In the case of non-exact sensing, a sensing residual is defined to quantify the error in motion sensing. Distributed actuators are designed based on the principle of moment excitation. Actuating spill over is also defined to quantify the error in motion actuation. A theorem of sensing residual is discovered, which reveals the physical nature of the sensing residual and its effect on active controlling process. An application example is presented.
Japan was in the forefront of tank technology in the 1930s, introducing a number of innovations such as diesel tank engines. Tank production in the 1930s was also much greater than that of many European armies, due to the conflict in China. In the period 1931 - 1938, the Japanese had built nearly 1,700 tanks, which put them into fourth place in the world behind only the Soviet Union, France and Germany. \| By the time the Japanese started their war with China in 1937, they had eight tank regiments in the field. \| Japanese tank units played a key role in the early victories of December 1941- January 1942 against the US Army in the Philippines and the British Army in Malaya. Despite their success, after 1941, the shift in strategic focus of the Japanese war effort changed industrial priorities from the needs of the army \| to warship and aircraft construction, so tank production fell in the later years of the war. \| However, Japan did continue to build tanks, even to increase output during 1940 and 1941. But after reaching peak annual production in 1942 the tank building industry declined and was unable to catch up. Japan's most modem tanks were reserved for a last-ditch defense of the Home Islands in 1945 - a final battle that never took place.
from board import Board class Game: def __init__(self, player_x, player_o): self._board = Board() self._player_x = player_x self._player_o = player_o self._current_player = player_x def run_game(self): # print("Starting a new game.") is_game_complete = False winner_symbol = None while not is_game_complete: self._board.print_board() move_tuple = () current_player_symbol = self.__get_player_symbol(self._current_player) non_current_player_symbol = self.__get_player_symbol(self.__get_non_current_player()) while not self._board.make_move(move_tuple, current_player_symbol): move_tuple = self._current_player.move(self._board, current_player_symbol, non_current_player_symbol) self.__get_non_current_player().update_opponent_move(self._board, non_current_player_symbol, current_player_symbol) is_game_complete, winner_symbol = self._board.check_game_complete_and_get_winner_symbol() self.__switch_player() self.__forward_match_winner_results(winner_symbol) if winner_symbol: print("Player {player_symbol} won.".format(player_symbol=winner_symbol)) else: print("It's a draw.") def __get_non_current_player(self): return self._player_x if self._current_player == self._player_o else self._player_o def __forward_match_winner_results(self, winner_symbol): self._player_x.receive_game_results('x', winner_symbol) self._player_o.receive_game_results('o', winner_symbol) def __get_player_symbol(self, player): if player == self._player_x: return "x" elif player == self._player_o: return "o" def __switch_player(self): self._current_player = self._player_o if (self._current_player == self._player_x) else self._player_x
- Setting up your NEEO for the first time - Is the NEEO app needed for setup? - NEEO can't find my Wi-Fi network - Can I use NEEO with my own power supply? - How can I create a NEEO Account? - Can you add support for my favorite devices? - Do you have a community? - How can I join the BETA Team? - Can I use NEEO without internet connection? - Does my Smartphone and the NEEO Brain needs to be in the same Network? - Where can I find the serial number? - If I have two NEEO Remotes will one over-rule the other? Ask our community Get help from our friends on Planet NEEO, the place to share your stories, ideas and requests.visit planet neeo
ढाई माह की है और उनके पास बिस्तर पर ही थी। गांव निवासी टेड़ई के दो बैल भी करंट की चपेट में आने से मर गए। 25 से 30 घरों के बिजली के उपकरण जल गए। इससे लोगों को दो लाख रुपये से अधिक का नुकसान हुआ। कई घरों की वायरिंग जल गई। ग्रामीणों का कहना है कि 33 हजार वोल्टेज के तार के ढेर नीचे लटक जाने व जर्जर हो जाने की जानकारी लिखित रूप से दो माह पूर्व विजली बिभाग के अधिकारियों को दी गई थी। लेकिन विभागीय अधिकारियों व कर्मचारियों की लापरवाही के चलते घटना घट गई। ग्राम प्रधान इंद्रावती देवी ने बताया की जर्जर तारों से की जा रही बिजली आपूर्ति के विषय में बिजली विभाग के अधिकारियों को अवगत कराया गया था फिर भी उसको नहीं सुधरवाया गया। बरसात के दिनों में करंट से ज्यादा खतरा बना है। इसलिए जर्जर तारों की मरम्मत करानी चाहिए, पर विभाग पहल नहीं कर रहा है। इसके लिए आंदोलन किया जाएगा। मुंबई। अमिताभ बच्चन ( ) फिलहाल कौन बनेगा करोड़पति सीजन 12 () होस्ट कर रहे हैं। इसके लिए उन्हें करीब 1517 घंटे काम करना पड़ रहा है। बिग बी शूटिंग में इतने बिजी हैं कि कई बार वो</s>
Bright lights in the big city – Buenos Aires never fails to stun with its beautiful architecture and unique rhythm © alex_black, Shutterstock Part New York, part Paris, but all Buenos Aires, this vast city never gives a dull first impression. Beautiful European architecture stands among the bland North American-style high-rise buildings, garish neon lights and advertising billboards. Cobbled old artisan streets lead to 21st-century docklands development, and then to a riverside wilderness. The energy of big-city traffic and gridlock, the pulsing nightlife where dinner can start at midnight, and the large and long-established metro system imply prosperity – though there’s bleak backstreet poverty too. The city’s inhabitants came to be referred to as porteños or port residents, a great mix of Italian, Spanish, British, Jewish, Afro-Argentine, German, and Portuguese immigrants. It is a unique city within Argentina and the people even have a characteristic accent that differs from the rest of the country. The city effortlessly blends South American colour, rhythm and spice with European elegance, style and sophistication and North American economic and commercial ambitions, all the while maintaining a culture, a language, folklore, music and dance that is purely Argentine, and distinctly porteño. And yes, tango really is everywhere, from the gaudy street-dancer kitsch of Caminito to the urgent city-music fusion pouring out of shops and restaurants. The city is referred to as the Capital Federal, or sometimes the Ciudad Autónoma de Buenos Aires or Autonomous City of BA, or shortened to ‘BsAs’. It has a population of over three million; the metropolitan area of Gran Buenos Aires, also known as the Gran Aldea (great village), includes the Capital Federal and surrounding districts, or partidos, and reaches a population of 13 million. Around 1910, Buenos Aires became the first South American city to reach a population of one million; its inhabitants came to be referred to as porteños or port residents, a great mix of Italian, Spanish, British, Jewish, Afro-Argentine, German, and Portuguese immigrants. It is a unique city within Argentina and the people even have a characteristic accent that differs from the rest of the country. Buenos Aires was actually founded twice, some say even three times. The first was in 1536, by Pedro de Mendoza, leading one of the first Spanish expeditions to Argentina. He arrived at a large estuary that had been previously claimed by Juan Díaz de Solís in 1516 on the first, and unfortunately fatal, expedition to Argentina, sailing down from Brazil in search of a southern passage to the Pacific. This second voyage followed the fall of the Inca Empire in 1532; the King of Spain, Carlos I, sent Mendoza’s group to counter Portuguese advances in the territory. The group was able to settle on the southwestern bank of the estuary, and the settlement was soon named Nuestra Señora Santa María del Buen Aire. However, the native Americans who were long established in the area did not perceive their lands as available for settlement. Their warriors, who had already become skilled horsemen, launched repeated attacks upon the settlement and any exploration parties it attempted to send out. Shortage of food and supplies led Mendoza to abandon the settlement in 1537. It was not until 1580 that Buenos Aires was founded for the second time at the ‘River of Silver’ (Río de la Plata, or River Plate) by Juan de Garay. His intention was to establish the Río de la Plata as a gateway for trade. It was during these early days of pioneering the pampas that the leather and beef industry was born, and so was born the famous gaucho or Argentine cowboy. Rudimentary plans for a town took shape with streets laid out in a grid. In the centre was established the Plaza Mayor, today the Plaza de Mayo, and a fort was erected on the site where the Executive Office Building now stands. Buenos Aires was subordinate to Asunción, which was in turn subordinate to the Viceroyalty of Lima, which was subordinate then to Madrid, the Spanish capital; it would take a couple of centuries for Buenos Aires to grow and match Lima’s level of power and status. Meanwhile, it was cut off from communication with Spain owing to colonial and mercantile bureaucracy. The large trading fleets from Spain would stop in Cuba and at Portobello on the Isthmus of Panamá, send their goods by mule across the isthmus to the Pacific and load them onto fresh ships for Callao, near Lima. This route was relatively safe from attack but very lengthy and costly and Buenos Aires was quite neglected. Buenos Aires was only permitted to receive registered ships, sailing only every year or so, and up to five years could pass without a registered ship arriving from Spain. The porteños in those days suffered greatly under this system; culturally they could not adapt to the Querandí’s hunting-and-gathering lifestyle, and it was inevitable that bootlegging would become a means of survival. Against Spanish authorisation, the porteños began trading with the British and Portuguese vessels that passed; and what they had to trade was leather. Cattle and horses abandoned by the Mendoza expedition had by this time grown into semi-wild herds that populated the pampas. The leather was too crude to trade with Spain, but it was acceptable for contraband trade. It was during these early days of pioneering the pampas that the leather and beef industry was born, and so was born the famous gaucho or Argentine cowboy. The colourful street museum and alley of Caminito in the La Boca neighbourhood © Luis Argerich, Wikipedia The increase in commercial activity, smuggling and the slave trade caused Buenos Aires to expand. By 1776, its population exceeded 25,000; Spain had come to recognise the importance of Buenos Aires and in that year made it the capital of the newly created Viceroyalty of the River Plate, which included the wealthy silver region of Potosí (in present-day Bolivia). In 1778, the Atlantic ports were allowed to trade freely, giving a big boost to the city’s growth. In 1800, the British Empire began implementing its colonial expansion policies and the Río de la Plata was in its sights as a potential British base for trade. The first attack on Buenos Aires in 1806, led by Commander Beresford, was opposed by Spanish troops led by Santiago de Liniers from Montevideo (taking command in the absence of Viceroy Rafael de Sobremonte, who had fled at the onset of the attack), together with an urban militia of Spanish civilians, Creole patricios and peasant gauchos. The battle was short and the British force surrendered and was interned in Luján. A second ill-advised attack in July 1807 by 10,000 men under Major-General John Whitelock was repelled by the heroic defence of the urban militia, aided by women and children using such tactics as pouring boiling oil and water from windows and rooftops and firing cannons from balconies (in particular the balcony of Defensa 372, now the Museo Nacional del Grabado). Whitelock’s headstrong frontal attack on the fortified city resulted in the immediate loss of almost a third of his men. He accepted a truce offered by Liniers and was evacuated to Montevideo, from where he returned to Britain to face court martial. These battles are known as La Reconquista and La Defensa and were remarkable because the residents themselves, the porteños, organised their own defence without the aid of the colonial power and with decisions being made without reference to Madrid or intervention from the viceroy. Meanwhile in Europe, Napoleon had crossed Spain to invade Portugal (allied with Britain) with the assistance of Charles IV; Charles was forced to abdicate and was replaced on the throne by Ferdinand. Napoleon forcibly re-established Charles as king, in order for Charles to then yield it to Napoleon, who then put his brother Joseph on the Spanish throne. This created anti-French sentiment in Buenos Aires leading to the execution of Liniers solely on the basis of his French name. On 25 May 1810, the citizens of Buenos Aires revolted and disposed of Viceroy Sobremonte for he was seen as a coward and not capable of protecting the River Plate. The May Revolution of 1810 replaced him with an autonomous governing body. Buenos Aires itself had reached a population of over 300,000, and recognisable neighbourhoods, barrios, had been established. Some consider the city to have had a third founding with mass immigration in the late 19th century. A century later, Buenos Aires’s population had grown eightfold and the city was modern and cosmopolitan. The first subway line (the first in Latin America) opened in 1911, and the city’s first skyscraper, the Barolo Building, appeared in 1920. By 1950, Buenos Aires was one of the largest cities in the world.
The Deity and Ministry of the Holy Spirit looks at who is the Holy Spirit and what role does He play in the Trinity and in the life of the Christian? This five part series explores the above question and reveals the vital ministry the Holy Spirit performs at salvation and continuing in the believers journey to maturity. The teachings include: - The Deity of the Holy Spirit - The Holy Spirit and Salvation - The Holy Spirit's Ministry In Us - The Holy Spirit's Ministry Through Us - The Baptism in the Holy Spirit
Learn something new every day More Info... by email Pruritus vulvae is the medical term for a persistent, uncomfortable itch on and around the vulva. It is a very common problem among women of all ages, and most cases are caused by irritation from clothing, sweat, or mild allergic reactions to soaps or hygiene products. In some instances, however, pruritus vulvae can be a sign of a more serious underlying condition, such as a sexually transmitted disease or a yeast infection. Home remedies and over-the-counter products are usually successful at treating minor pruritus vulvae symptoms. An itch that persists for more than a few days or becomes distressing enough to affect daily life needs to be addressed by a doctor. Many factors can contribute to pruritus vulvae, including poor hygiene practices, using scented soaps or cleansers, and wearing tight underwear made from synthetic materials. A woman may also experience an allergic reaction to a particular feminine hygiene product, clothing detergent, or contraceptive that causes redness and itching around the vagina. Bacterial and fungal infections are not as common, but they can represent potentially serious health problems when they occur. In most cases, frequent or constant itching is the only symptom of pruritus vulvae. The skin may appear redder than usual or develop a bumpy rash due to inflammation. If an underlying infection is present, there may be swelling in the area and a white or yellow foamy discharge from the vagina. Urination and sexual intercourse might be painful, and the condition can make it difficult to rest comfortably at night. Many women find that their symptoms tend to worsen when they are under a lot of stress. Relatively mild instances of pruritus vulvae tend to respond well to home treatments. A woman can usually relieve itching by washing her vulva twice daily with warm water and avoiding chemical irritants such as soaps and perfumes. It is helpful to wear loose-fitting cotton underwear to reduce friction and prevent excessive sweating in the genital region. If itching persists, an over-the-counter unscented moisturizer or anti-inflammatory cream may help. Doctors strongly discourage women from scratching, as doing so can cause further irritation and leave the skin more susceptible to bacterial infections. Women who experience lasting symptoms should schedule appointments with their gynecologists. A doctor can physically inspect the vulva and ask about symptoms to make a basic diagnosis. He or she might decide to test blood, urine, or skin samples to screen for different types of underlying infections. In addition to encouraging home care techniques, the doctor may prescribe a high-strength antibacterial or antifungal medication to use for about two weeks. With treatment and follow-up preventive care, most cases of pruritus vulvae can be cured.
Construct the likelihood with asymmetric uncertainties I want to study the correlation between 2 parameters, this is done by fitting a straight line. I have uncertainties on both parameters. I want to solve my problem using the Bayesian approach, i.e. I construct my likelihood, assume some prior information on the slope and $y$-intercept, and then I will get my posterior distribution. Then I would sample from my posterior distribution using MCMC. The first step would be to construct my likelihood: Assume the data come from a line of equation $y = mx + b$. Then the likelihood would be: $$P(D\|\theta, I) = \frac{1}{\sqrt{2\pi \sigma^2}} \exp(-\frac{(y - mx - b)^2}{2\sigma^2})$$ However, in my case the uncertainties are asymmetric, how can I construct my likelihood? For example, my data look something like this: $x^{\sigma +}_{\sigma -}$ and $y^{\sigma +}_{\sigma -}$ One way to solve this out is to calculate the average of the lower and upper uncertainties, so that: $$\sigma = \frac{\sigma^+ + \sigma^-}{2}$$ Now I have symmetric uncertainties, and then I will be able to construct my likelihood. Is there another method to solve this out? • You need to choose a distribution that models your measurement errors. Gaussian obviously can't capture the asymmetry. Can you put your measurement error data plotted so that we can recommend a likelihood? Apr 12, 2015 at 14:59 • @Memming, my data do NOT come from repetition of measurements. My data resembles properties of exoplanets. So, for example let's assume I have 10 different planets, each data point refers to the mass of the exoplanets. Example: mass of planet 1 = $3^{+1}_{-0.25}$. I am assuming that the errors are drawn from a normal distribution with mean 0 and variance $\sigma^+$ and $\sigma^-$. Apr 12, 2015 at 15:07 • I see. You could cut two Gaussians in half, and stitch together to make a frankenstein distribution in that case. Apr 12, 2015 at 15:20 • @Memming Can you give me please more details or references, this is the first time I come across cutting 2 gaussians in half! Thanks a lot :) Apr 12, 2015 at 15:23 You could cut two Gaussians in half, and stitch together to make a split normal distribution of your noise $\epsilon$: $$P(\epsilon) = N(\epsilon; 0, \sigma^+)I(\epsilon > 0) + N(\epsilon; 0, \sigma^-)I(\epsilon < 0)$$ where $I$ is the indicator function. Below is an example probability density function.
[purchase_link id=”4521″ text=”Add to Cart” style=”button” color=”blue”] The height comparison tool works for a wide variety of people and objects. For example, you can compare celebrity heights. Other height comparisons include presidents, nationalities, hominids, fictional characters, athletes, animals, buildings, vehicles, and even celestial objects. The height comparison tool can also do custom height comparisons where you input height measurements and perhaps even a custom image. Press the ‘Next’ button to see another random height comparison. Otherwise, use the forms labeled ‘Left’ and ‘Right’ below to setup your own height comparison. Choose a category and subject to compare and then press the update button. Don’t forget to share your height comparison by using the copy to clipboard button and pasting it on social media or anywhere on the web. See below for more information on the height comparison tool. Units: imperial metric Using the Height Comparison Tool The height comparison tool can be used in the basic way explained above. It can also be used to do custom comparisons. For example, if you want to compare your own height with, say, Robert Wadlow, you can do so as follows: Set Robert Wadlow for one side, and then for the other side select the category ‘Average Person’ and then select either average male or female. Next input your height. If you want to get a bit more advanced, you can take a picture of yourself, crop it so that there is no space above or below your body (you can do this with Microsoft Paint or Word), and then upload it to a file sharing service such as Drop Box. Next, get the url for the image and paste it in the Image url text box. You might have noticed the adjustment field. This is to account for such things as footwear, like high heels, and slouching. It is typically set at 1” as that is the approximate thickness of most shoes. But for celebrity height comparisons where women often have high heels, the adjustment can be changed to, say, 4”. To see an example of this, consider the Jennefer Aniston height comparison with Zeng Jinlian, the tallest women on record to have lived. While Jennifer Aniston is wearing what look to be about 4″ heels, Zeng Jinlian is hunched over with her scoliosis and so is given a -4″ adjustment. The adjustment field can also be used for other objects such as, say, a flag pole or antennae on a skyscraper. The height comparison tool can also compare lengths as follows: If the width of an image is much greater than the height, the length data is also provided in the output. The length data is secondary as it is dependant on the image proportions, and thus may not be as accurate. That being said, subjects like the Titanic and Blue Whale were added with correct length as the priority. To achieve this for a custom image, set the height to the true length multiplied by the image height in pixels over the image width in pixels. Units for Height Comparisons You can select between metric and imperial. The input is then either cm or inches and feet. The output automatically changes to larger units such as m, km, and miles as larger objects are compared. The Height Comparison Scaling Exponent You may have noticed the scaling exponent field. This is the power to which height scales with mass by, and thereby volume too. Other height comparison tools assume a cubic relationship, where proportions are maintained as people get larger. This is in contrast to the Body Mass Index, which assumes a square relationship. In actuality, humans scale somewhere between cube and square, somewhere around 2.5. That’s why this is the default scaling exponent. The scaling exponent only comes into play when doing height comparisons that use the default male and female silhouettes. This is because these, unlike the specific images, must scale to a variety of sizes. With a scaling exponent of 2.5, people get a bit narrower as they get taller. If you increase this number, this will be diminished and vice versa. Origin of the Height Comparison Tool The height comparison tool was originally built to give people an appreciation for tall people and height differences. This explains the presence of Robert Wadlow, Zeng Jinlian, and Yao Ming. The project grew from there to look at tall outside of humans and that’s where Chewbaka, the Saturn V rocket, and the Burg Khalafi came in. Going forward, the plan is to include anything noteworthy for height, whether tall or short, as well as interesting for comparisons sake. This includes ancient hominids, presidents, athletes, celebrities, fictional characters, and inanimate objects. Who wouldn’t want to see what Lebron James looks like next to Bigfoot? Perhaps you feel like contributing to the height comparison project. The simplest way is to gather some height data, preferably in metric, and send it to [email protected]. If you have time, images would be helpful too. Please remove the backgrounds and crop to fit the subject. There are many programs you can do this with, Microsoft Word being just one. If you do provide images, please make sure they can be shared for free, such as with a Creative Commons license (Flickr and Wikicommons are good places to look), and please include the attribution link or html code. So what do you think of the height comparison tool? Do you have any suggestions? Please share your comparisons by using the copy to clipboard button and posting it to social media or anywhere on the web.
Container Closure Integrity Testing is performed to evaluate the adequacy of a closure in maintaining a sterile barrier. Of primary concern is whether the container can provide an effective barrier against ingress of microorganisms and other substances that may compromise or contaminate the product. In the past, sterility testing was performed to demonstrate container integrity; however, due to the insensitivity and other complications associated with sterility tests, a variety of container and closure integrity tests were developed. While no strict standard exists for all integrity test methods, the Parenteral Drug Association (PDA) Technical Report (TR) 27 and FDA guidance on the subject does have recommendations for integrity test performance. It is recommended that container closure integrity testing during initial packaging validations incorporate both physical and microbial challenge tests. Nelson Labs offers a variety of methods to evaluate container closure integrity. The microbial challenge test is performed as a direct evaluation of the container and closures ability to prevent microbial ingress. All sterile pharmaceutical containers must not allow organisms into the container which would contaminate the product. A commonly accepted microbial challenge method is integrity testing via microbial immersion. The PDA TR 27 encourages that the challenge should simulate worst-case production and shipment conditions. At Nelson Labs we have a unique challenge apparatus, which allows testing to be performed under a variety of both negative (vacuum) and positive pressures. This allows simulation of all types of production and shipment methods, including air freight. Many manufacturers are not sure when or how often they should conduct Container Closure Integrity, but the testing is extremely important to ensure the product will remain sterile in the package configuration for the shelf life of the product. Container Closure Integrity Testing should be conducted during the initial packaging validation. Additionally, as detailed in the FDA Guidance document on the subject, testing should be performed as part of the stability protocol in lieu of Sterility Testing. Testing should be conducted annually on production lots to monitor for any changes in the process and/or materials.
Large inguinal bladder hernias: can a preoperative diagnosis be made? ConclusionThe main objectives in treatment of inguinal bladder hernia are to preserve the voiding function and to avoid bladder injuries in a tension-free hernia repair. To our knowledge, this is the first series of cases in which all inguinal bladder hernias were diagnosed preoperatively. CONCLUSIONS: Ovarian inguinal hernias should be considered among the differential diagnoses of a groin mass or swelling. In women of reproductive age, repair of the hernia with the intent to preserve fertility is of critical importance. PMID: 31696731 [PubMed - as supplied by publisher] Conclusion: A combination of laparoscopic reduction and nonsutured PEG gastropexy is a safe and effective alternative treatment for high-risk patients (with significant morbidity and mortality) with symptomatic PHs. Most patients (80%) returned to normal oral intake postprocedure and were discharged home within 3 d. PMID: 31624456 [PubMed - in process] ConclusionAs PDH can lead to major and life threatening complications, it must remain in our minds as a possible cause of intestinal obstruction. Abstract Lumbar hernias are from weakened areas in the posterior lateral abdominal wall. Minimally invasive techniques are recommended for nonmidline abdominal wall hernias. Endoscopic methods utilizing the subcutaneous space only are rarely reported. A 66-year-old man presented with abdominal pain and a computed tomography (CT) scan revealing a lumbar hernia. The procedure was done utilizing the subcutaneous space to open the hernia sac and repair the defect in layers. A sublay mesh and an onlay mesh were used within the subcutaneous pocket. The patient had an uneventful postoperative course and was discharged ho... We present a case of a 60-year-old male patient presented with bilateral inguinal swelling associated with urinary hesitancy and intermittency. He had undergone transabdominal preperitoneal (TAPP) repair for a left inguinal hernia 8 years ago. CT scan confirmed the presence of a bilateral hernia with the bladder herniating bilaterally. He underwent an elective bilateral open Lichtenstein tension-free mesh repair. AbstractForamen of Winslow hernia (FWH) is an extremely rare entity accounting for up to 8% of internal hernias and 0.08% of all hernias. Only 150 cases of FWH have been described in the literature to date with a peak incidence between the third and sixth decades of life. Three main mechanisms seem to be implicated in the FWH pathogenesis: (a) excessive viscera mobility, (b) abnormal enlargement of the foramen of Winslow, and (c) changes in the intra-abdominal pressure. The presence of an abnormally long bowel, enlargement of the right liver lobe or cholecystectomy, a “wandering cecum,” and defects of the gastr... Publication date: Available online 19 July 2019Source: International Journal of Surgery Case ReportsAuthor(s): Dario Iadicola, Massimo Branca, Massimo Lupo, Eugenia Maria Grutta, Stefano Mandalà, Gianfranco Cocorullo, Antonino MirabellaAbstractIntroductionTraumatic diaphragmatic injuries are rare complications resulting from a thoracic-abdominal blunt or penetrating trauma. Left-sided diaphragmatic injuries are more commonly reported in literature. Bilateral injuries are extremely rare, occurring in about 3% of the patients and just few cases reported in literature. Traumatic diaphragmatic hernias are definitely a m... ConclusionThe introduction of a liquid material which solidifies after injection in a short time (hydrogel) using a needle is feasible. The combined CT-scan and US image guidance allows for the percutaneous placement of the needle in the required location. The introduced hydrogel remains in this space, corresponding to the inguinal region, without moving. The placed hydrogel compresses the posterior wall composed of the transversalis fascia, supporting the potential use of hydrogel for hernia defects. ConclusionThe clinicians should consider this rare condition in the differential diagnosis of patients presenting with large paraumbilical hernias associated with classical symptoms of acute pancreatitis, particularly in the absence of typical risk factors for pancreatitis. An intravenous contrast-enhanced abdominal CT scan should be performed immediately in these patients. We recommend the patients and the surgeons to consider prompt surgical repair for paraumbilical hernias to avoid further complications and the higher incidence of morbidity and mortality associated with emergency surgeries. ConclusionGradual postoperative closure of a traumatic abdominal wall hernia with an ostomy in place may result in stomal stenosis. Stomal patency must be carefully evaluated during this process.
Below 300 (inshore waters) in British waters A bottlenose dolphin may be black, brown or dark grey on its back, with lighter flanks. They have a tall, sickle-shaped dorsal fin and pointed flippers. Bottlenose dolphins are highly social, intelligent animals, and individuals often co-operate in activities such as hunting, baby-sitting and defence against predators. They are most often found in small groups (of two to 50 animals), and alliances and relationships between individuals are complex. They are capable of problem solving and tool-use, and are inquisitive and playful, frequently seen riding the bow waves of ships and large whales. Length: 3.2 – 3.6m (males are slightly larger than females on average) Weight: Up to 650kg Lifespan: 40 – 45 years (males); up to 50 years (females) Mating occurs throughout the year but in British waters most births are between May and November. A single calf is born after a gestation of about 12 months and is dependent on milk for 18 to 20 months. It may continue to suck for several years while swimming, hunting and social skills are developed. Fish (including haddock, hake, trout, bass and sandeels), cephalopods and crustaceans. Inshore areas include estuaries and harbours, with brief forays into fresh water. Bottlenose dolphin are also found in more offshore waters. Killer whale and shark predation is less common in British waters than elsewhere. Boat strikes and entanglement in fishing gear, pollution and depletion of fish stocks. Status & conservation Native. It is a UKBAP priority species and is legally protected in British, Irish and European waters. Habitats in the Moray Firth in Scotland and Cardigan Bay in Wales are designated as Special Areas of Conservation under the EU Habitats Directive. UK population size & distribution Several hundred are resident in British waters. Resident populations in the Moray Firth and Cardigan Bay, and commonly spotted off the coast of southern Ireland and southwest England. Two semi-resident groups are found off the UK coast, in Cardigan Bay and the Moray Firth, which have both been designated SACs. Elsewhere, there are smaller groups off south Dorset, around Cornwall and in the Sound of Barra, Outer Hebrides. Did you know? Females sometimes act as midwives, helping during births by supporting the mother in the water or by pushing the calf up to the surface to breathe. One individual was observed biting through the umbilical cord.
Raph Koster introduces himself as an alien from another planet: a game designer. He's the author of The Theory of Fun. He starts by introducing structure in music and art with some cool audience participation. There are different dimensions to fun: Hard fun is about solving problems. The problems tend to be mathematical Therefore the grammar of hard games ignore presentation. He applies the theory of fun to Amazon.com and concludes that it's not structural, not fun. There a lots of sequential steps and don't provide any "fun" or feedback. The magic ingredients: - Territory - where you meet the challenge matters. Doing the same thing in different places should make a difference. The topology should affect the available options. - Preparation - when you buy it, what pages and interactions you saw should matter. Everything you did before should matter. The last interaction you had should matter (think of your opponents last move). Never start an interaction with no context. You must prepare for the encounter. - How - should involve skill on your part (eBay is more fun than Amazon). The core verb should be repeatable. Tricks and tips should matter. You should feel like you're growing more competent. Competition is an important element and people need to be able to see it. - What - buying different things should feel different. The same verb must be applicable in many different challenges. A given verb is a hammer. You should present them with lots of nails. - With - what tools you use should matter. Give users an array of tools to solve the problem. The system should give the user different rewards of different feedback based on how the challenge was met. - For? - you need feedback. A game that has only one possible outcome is boring. A lot of services drive you toward a given outcome and then they stop. Usually, the best feedback is a grater challenge. Sometimes it's a pleasant surprise. Either way it has to be highly visible. - Few? - don't always get what you want. Low risk activity for high reward is bad for fun. You need to drive users to challenges at the edge of their ability. - Phooey - fun comes from learning. Failure is important to learning. Making a wrong choice has to be a set back. Fun won't exist if there's no consequence. All of this can be quantified. You can give people ratings for how hard it is to accomplish a particular task. What is the challenge rating for buying a particular book at Amazon?
# Points A(3, 1), B(5, 1), C(a, b) and D(4, 3) are vertices of a parallelogram ABCD. Find the values of a and b. - Mathematics Sum Points A(3, 1), B(5, 1), C(a, b) and D(4, 3) are vertices of a parallelogram ABCD. Find the values of a and b. #### Solution The given points of the parallelogram are A(3, 1), B(5, 1), C(a, b) and D(4, 3). We know that the diagonals of a parallelogram bisect each other. So, O is the midpoint of AC and DB. So, ((3+"a")/2 ,(1+"b")/2) =((5+4)/2, (1+3)/2) ⇒ ((3+"a")/2 ,(1+"b")/2) = (9/2,4/2) ⇒ ((3+"a")/2 ,(1+"b")/2) = (9/2,2) On comparing we get (3+"a")/2 =9/2 ⇒ 3 + a = 9 ⇒ a = 6 Also, (1+"b")/2 = 2 ⇒ 1 +b = 4 ⇒ b = 3 Thus , a = 6, b = 3 Concept: Similarity of Triangles Is there an error in this question or solution?
- Cooking Time: - Preparation Time: - 1 tablespoon of oil - 2 tablespoons of butter - 1 tablespoon of grated lemon rind - 2 tablespoons of lemon juice - 2 tablespoons of fresh oregano leaves - 4 beef steaks, thick - black pepper - lemon slices or wedges for garnishing - Put oil and butter in a pan over medium heat. Add the lemon rind, lemon juice and oregano and sauté for 3-4 minutes. - Remove mixture from pan. - Increase temperature to hot. - Sprinkle steaks with pepper and cook in pan; cook each side for 3-4 minutes. - Arrange beef on a serving platter, sprinkle with lemon and oregano mixture. - Serve with fresh beans and pour the pan juices all over. - Garnish with lemon
When kids have trouble communicating If your child has language troubles, you’re not alone. Around three to five per cent of children experience difficulties in this area. The great news is that most language issues can be overcome or minimised with the right speech-language therapy. A child with language difficulties may have trouble understanding written and spoken language or gestures (known as receptive language), or find it hard to express themselves through the spoken or written word (known as expressive language). You might notice your child has trouble listening or following instructions. They might not have many words or speak infrequently, become frustrated because they can’t express themselves, give unusual answers to questions, or struggle to form clear written or spoken sentences. Below are the two main types of language difficulties for children, and what to expect from both. Receptive language Receptive language is the ability to understand words and signals. Children with receptive language issues may have trouble understanding what is being said or asked of them. Some children with receptive language difficulties become adept at picking up on key words or gestures. When this happens, it may appear like they understand what is being communicated when in fact they are using clues to guess and respond. Depending on their age, children with receptive language difficulties might: Struggle to understand and follow instructions Appear like they aren’t paying attention Repeat a question instead of providing an answer Give an unusual answer, as though they haven’t understood the question Have trouble concentrating on what’s being said Withdraw and avoid certain tasks and activities Expressive language Expressive language is the ability to communicate using words, facial expressions and gestures. Children with expressive language issues can usually form words, but have trouble understanding how words and sentences fit together to form meaning. Depending on their age, children with expressing language difficulties might: Have difficulty finding the right words to express themselves Not be talking Use shorter words and sentences compared to children of a similar age Frequently use the wrong words or leave out words in sentences (they might say “I going” instead of “I am going”) Have difficulty answering your questions Have difficulty telling you what they have been doing or retelling a story Often rely on using familiar phrases when speaking with others Remember, children develop language skills at different rates. Sometimes, they simply need a little extra help to catch up with their peers. Our Speech Pathology team can provide assessment and support for your family. Contact us for more information.
* All date and time are in GMT (UTC) time. User Activity Analysis With iPracticeMath, you are able to keep track of your tests, worksheets and other activities, and also gauge your own performance. - Generate a detailed report of all the tests attempted . - See how many questions you answered correctly - Find your accuracy rate for each topic and subtopic. - View total number of questions between specific dates or in a given time period. - Know your strong and weak areas in math. - See detail report for each subtopic. Please sign in to see your students performance analysis reports. Become a Member. Enjoy great benefits! - Track progress in real-time - Easy access to specialized user reports - View progress history - Get notified when new topics are added - Quiz and additional worksheets (coming soon) - Special certificates for registered users Register as teacher
टाटा संस के चेयरमैन बनाए जाएं, उन्हें हटाना गलत था। हालांकि, न्यायाधिकरण ने कहा कि बहाली आदेश चार सप्ताह बाद अमल में आएगा। टाटा संस को अपील करने के लिए यह समय दिया गया है। बता दें कि एनसीएलटी में केस हारने के बाद मिस्त्री अपीलेट ट्रिब्यूनल पहुंचे थे। एनसीएलटी ने नौ जुलाई, 2018 के फैसले में कहा था कि टाटा संस का बोर्ड सायरस मिस्त्री को चेयरमैन पद से हटाने के लिए सक्षम था। मिस्त्री को इसलिए हटाया गया, क्योंकि कंपनी बोर्ड और बड़े शेयरधारकों को उन पर भरोसा नहीं रहा था। अपीलेट ट्रिब्यूनल ने जुलाई में फैसला सुरक्षित रखा था। बता दें कि अक्तूबर 2016 में सायरस मिस्त्री टाटा संस के चेयरमैन पद से हटाए गए थे। दो महीने बाद मिस्त्री की ओर से सायरस इन्वेस्टमेंट प्राइवेट लिमिटेड और स्टर्लिंग इन्वेस्टमेंट कॉर्प ने टाटा संस के फैसले को एनसीएलटी की मुंबई बैंच में चुनौती दी थी। कंपनियों की दलील थी कि मिस्त्री को हटाने का फैसला कंपनीज एक्ट के नियमों के मुताबिक नहीं था। जुलाई 2018 में एनसीएलटी ने उनके दावे को खारिज कर दिया। बाद में सायरस मिस्त्री ने खुद एनसीएलटी के फैसले के खिलाफ अपील की थी। पुलिस का कहना है कि किशोरी लगातार बयान बदल</s>
पिताजी जोर से चिल्लाते हैं । प्रिंस दौड़कर आता है पूछता है क्या बात है पिताजी? प्रिंस लेकिन मेरी गाड़ी तो मेरा दोस्त ले गया है सुबह हीऔर आपकी गाड़ी भी ड्राइवर ये कहके ले गया की गाड़ी की ब्रेक चेक करवानी है। पिताजी ठीक है तो तू स्टेशन तो जा किसी की गाड़ी या किराया की करके? उसे बहुत खुशी मिलेगी। पिताजी तूझे शर्म नहीं आती ऐसा बोलते हुए ? घर में दो-दो गाड़ियां होते हुए भी घर की बेटी किसी टैक्सी या आटो से आयेगी ? क्या उसे हम सबका प्यार पाने का हक नहीं ? तेरा जितना अधिकार है इस घर में उतना ही तेरी बहन का भी है। कोई भी बेटी या बहन मायके छोड़ने के बाद वह पराई नहीं होती। मम्मी आप कुछ शरम तो कीजिये ऐसे जवान बेटे पर हाथ नहीं उठाते। पिताजी तुमने सुना नहीं इसने क्या कहा? अपनी बहन को पराया कहता है .ये वही बहन है जो इससे एक पल भी जुदा नहीं होती थी हर पल इसका ख्याल रखती थी। पाकेट मनी से भी बचाकर इसके लिए कुछ न कुछ खरीद देती थी। बिदाई के वक्त भी हमसे ज्यादा अपने भाई से गले लगकर रोई थी। और ये आज उसी बहन को पराया कहता है। प्रिंस -(मुस्कुराके) बुआ का भी तो आज ही जन्मदिन है पापा वह कई बार इस घर में आई है मगर हर बार आटो से आई हैआप कभी भी अपनी गाड़ी लेकर उन्हें लेने नहीं गयेमाना वह आज तंगी में है मगर कल वह भी बहुत अमीर थी आपकी और इस घर की उन्होंने दिल खोलकर सहायता और सहयोग किया है। बुआ भी इसी घर से बिदा हुई थी फिर रश्मि दी और बुआ में फर्क कैसा। रश्मि मेरी बहन है तो बुआ भी तो आपकी बहन है। कि तभी बाहर गाड़ी रूकने की आवाज आती है.तब तक पापा प्रिंस की बातों से पश्चाताप की आग में जलकर रोने लगे और इधर रश्मि भी दौड़कर पापा-मम्मी से गले मिलती है.. लेकिन उनकी हालत देखकर पूछती है कि क्या हुआ पापा? पापा तेरा भाई आज मेरा भी पापा बन गया है। रश्मि भाई की तरफ देखते हुए ऐ पागलनई गाड़ी न? बहुत ही अच्छी है मैंने ड्राइवर को पीछे बिठाकर खुद चलाके आई हूँ और कलर भी मेरी पसंद का है। प्रिंस हैप्पी बीर्थदय तो यू दीवह गाड़ी आपकी है और हमारी तरफ से आपको बीर्थदय गिफ्ट बहन सुनते ही खुशी से उछल पड़ती है की तभी बुआ भी अंदर आती है। बेटी और बहन दो बेहद अनमोल शब्द हैं जिनकी उम्र बहुत कम होती है। क्योंकि शादी के बाद एक बेटी और बहन किसी की पत्नी तो किसी की भाभी और किसी की बहू बनकर रह जाती है। शायद लड़कियाँ इसलिए मायके आती होंगी कि उन्हें फिर से बेटी और बहन शब्द सुनने को बहुत मन करता होगा ।
Graham, sharing his first post, has overcome his fear of bullying. Click to see Grahams post from 6/16/19 on @SoulEssenceChild Instagram. He has gained his inner strength through his energetic development and cannot be controlled by bullies. Afterall, when you understand it, the core of bullying is about energetic control of another person. Bullies use their sensing out of their fear of lack of control to fuel their bullying. Bullies, in their core of being, do not feel safe in the world. So, behind every bully is someone who is exercising control over them. They then move into the world looking to find a way to energetically control someone else, using bullying as a mechanism of control. Children who possess energetic boundaries are not affected by the energetic control of the bully. In a child’s energetic development Stage 01, Soul Self Entry is about gaining that internal control over self. Children listen to one voice file at night or in the morning for 30 days. It takes them through the labyrinth that has kept their soul from finding a way to be fully here on Earth. Being fully here brings them the internal control of self and therefore no matter how someone bullies them, the bully cannot control them. The children experience the safety of their internal self. The mechanisms of this have eluded humans until now – all can have energetic development. Purchase Soul Self Entry for your child. The voice files are appropriate for any human 6 years or older.
Many people live life unaware that they have hidden anger – suppressed anger that only occasionally surfaces. While this hidden anger is usually rooted in past childhood hurts, the underlying effects are always ready to surface on the scene. For example, when someone says or does something wrong, the one with suppressed anger often overreacts. When someone makes an innocent mistake, the magnitude of anger is out of proportion to the mistake. If you have hidden anger, you can find yourself at one extreme or another – from feeling hopeless to feeling hostile – and yet be totally unaware of why you are experiencing these feelings. The Bible makes it clear that some of our motives and emotions are hidden from our own view. Psalm 19:12 “Who can discern his errors? Forgive my hidden faults.” The hidden anger cues are: - Irritability over trivialities. - You smile on the outside, while you hurt on the inside. - You find your identity and worth in excessive work. - You deny ever being impatient. - You have to have the last word. - Those close to you say that you blame others. - You feel emotionally flat. - You find yourself quickly fatigued. - You have a loss of interest in life. - You become easily frustrated. When you discover that you might have hidden anger in your life, follow the counsel of Colossians 3:8 “You must rid yourselves of all such things as these: anger, rage, malice, slander, and filthy language from your lips.”
We are spending almost one fourth or one third of our life being schooled. What is the real purpose of school? To acquire knowledge/information? To be trained for jobs? To be a good person to society? Different people have different answers. Seth Godin gave several points in his video. One of his points on connecting dots emphasize on thinking instead of memorizing. Students need to be taught how to think and how to solve problems, not what to think and what to memorize. Once they learn the techniques of connecting dots, they will still be able to connect dots although the dots may change. Seth thinks there is no value to memorizing things. But I think memory work is necessary for learning. When students begin to learn a subject, they should first memorize facts, then understand and apply these facts into a creative process. If students are only tested about how much/how well they memorized (my school experience before I went to university), they will lose their interests. Before I went to university, I was taught to memorize things and I was tested about how well I memorized. In order to get a high score and be accepted by a good school, I need to focus on memory works. I often forgot the content after I turned in my tests. I didn’t know much about how to think. This is the wrong direction for education. Critical pedagogy suggests that teaching and learning should be contextual and aim at raising critical awareness among students. Critical pedagogy has been used by educators to refer to a broad range of pedagogies that employ critical theory, feminist theory, anti-racist theory, multicultural education, inclusive pedagogies, and so on. Geographic information systems (GIS) is an useful tool of critical pedagogy becasue it has the potential to help reproduce or transform oppressive conditions in society and it can be used to examine and build contexts that maximize students’ ability to analytically observe, consider, and respond to the world in which they live (Crampton and Krygier’s “An Introduction to Critical Cartography”). Below are two examples to illustrate how GIS can be used for critical educators to engage students in critical thinking. Veronica Velez, Daniel Solórzano, and Denise Pacheco explore the role of race and racism in shaping the historic, evolving spatial relationship between south Los Angeles high schools near the Alameda “Corridor,” and their surrounding communities. They apply GIS within a critical race methodology to examine geographic and social spaces, identify and challenge racism within these spaces as part of a larger goal of identifying and challenging all forms of subordination. They spatially examines how structural and institutional factors influence and shape racial dynamics and the power associated with those dynamics over time. Matthew W. Wilson’s Critical & Social Cartography seminar in Harvard Graduate School of Design asked students to think and make pretty maps by their analytical skills. In order to make pretty maps to reflect reality, what information should be included or excluded? How to represent different variables or types of information? How might a map designed to meet the needs? What would the students be required to do in order to create this map? Through the process of problem-posing, students were encoraged to think critically. Merging GIS and critical pedagogy requires that we ask how GIS can help students theorize from multiple perspectives about the role that space and spatial relationships play in their immediate lives, local communities, and beyond. As a widely applied tool, GIS can be applied to critical pedagogy. It is very inspiring to learn from this week’s reading materials that games (i.e., video games and role playing games) can contribute to student learning. Games are not only designed for fun. They can motivate and actively engage learners in the learning processs, and kills utilized in games can be translated to the real world. Thus, Game-Based learning and gamification get a lot of attention and are fast becoming used in the classroom (see more information about Game-Based learning from Jessica Trybus’s paper “Game-Based Learning: What it is, Why it Works, and Where it’s Going“). It seems like bringing games to the classroom might be an acceptable, even accredited, alternative strategy to education. I would also like to share an interesting TED talk by Jane McGonigal: Gaming can make a better world. According to McGonigal, if we can create engaging and fun games based on meaningful real world problems, we can leverage the combined knowledge, energy and enthusiasm to solve the world’s biggest problems and we can change the world. In the “Making the Grade: The Role of Assessment in Authentic Learning”, Marilyn Lombardi compared authentic assessment with traditional assessment. According to the information provided in Table 1, traditional assessments seem to have few positive characteristics. Thus, a movement from traditional assessment to authentic assessment improves teaching and learning (see more from Grant Wiggins’s “A True Test: Toward More Authentic and Equitable Assessment” and “The Case for Authentic Assessment“). From my experience, some mix of the two seem to be more appropriate and beneficial. As an instructor of an introductory Remote Sensing course, I applied traditional assessment tools (multiple-choice quizzes, short-answer exams, and essays) and authentic assessment (hands-on experiments, computer labs, and class projects). The combination of the two improves teaching and learning. Quizzes, which only have five multiple choice questions covering basic concepts and key ideas of a former lecture each time, help me measure students’ acquisition of knowledge and my teaching quality. When students made mistakes, they didn’t acquire the knowledge because of their misunderstanding or my unclear explanation. Then I can find another way to explain the concept clearly. The relationship between the time used to answer each question and accuracy of the question can reflect students’ learning in some way —shorter time with higher accuracy means students are likely acquire the knowledge, longer time with lower or even higher accuracy means students are not familiar with the knowledge, and shorter tiem with lower accuracy means students do not care. Hands-on experiments and computer labs, which are designed to introduce various useful equipments, software, and skills, help students apply the knowledge to solve real-world problems. Then students developed their own class projects related to their interests and I talked more about the topics they focused but not well covered in former classes. Authentic assessment complements traditional assessment but it increases my workload. My advisor is always trying to find a better way to mix the two for a large class. According to National Council for Excellence in Critical Thinking, critical thinking is “the intellectually disciplined process of actively and skillfully conceptualizing, applying, analyzing, synthesizing, and/or evaluating information gathered from, or generated by, observation, experience, reflection, reasoning, or communication, as a guide to belief and action.” Everyone endorses the teaching of critical thinking and every teacher try to build their teaching philosophy. But critical thinking taught in what fashion? And how to evaluate teaching effectiveness for critical thinking? In the field of Geography, there is a growing need for software training, especially for GIS and remote sensing. I think the best way to learn software is a question-driven approach or a project-oriented approach. Most of GIS and remote sensing courses use computer labs and customized class projects to help students to get familiar with software packages, and more importantly, to improve their skills in computer-aided problem-solving. Based on my experience as a teaching assistant and an instructor, two types of strategies are used mostly for computer labs. The first one is providing students with detailed step-by-step lab instructions. Students only need to follow the instructions and click the button even without thinking. There are less simple questions from students because they have all the information. But at the end of the courses, many students still know little about the software techniques. The second one is providing students with problems, goals and plenty of data. Students need to select their methods and data to support their analysis. It encourages students to think critically to solve the problems. Some students will find multiple ways to reach the goals and bring good ideas for their class projects, but many others, especially undergrads, still rely on instructors and teaching assistants to tell them step by step. They complain the second method is too hard and time consuming. They suggest instructors should provide step-by-step instructions from their evaluation. In such cases, evaluation is not effective. How to solve this mismatch problem? Blogging has become a popular and exciting activity in education. Teachers encourage students to write blogs or assignments, read and post comments on each others postings. It is a good way for communication and sharing ideas. Students will improve their writing and narrative skills with this activity. For seminar courses or courses in humanities and social science, blogging, instead of other traditional ways, may enhance students’ learning. However, for courses in natural science such as math or lab courses, I don’t think blogging is necessary or even useful. When teachers consider to use blogging for education purpose, they should think about the reason to use it, not just because it is popular and fancy. W. Gardner Campbell, Scott Rosenberg, Tim Hitchcock, Seth Godin and Tom Peters who only emphasize on the goodness of blogging are all from humanities and social science, I think people from natural science probably have different voices. Blogs are also used in middle and high school. Middle and high school blogging is like a web-based course site (blackboard, scholar, instructure canvas, etc) to provide information to students, parents, administration, or other teachers. Their blogs may include announcements, assignments, and discussion forum. Students can use blogs to discuss various topics and to interact with their teachers. Parents can use blogs to understand what is occurring in the class. The idea sounds great but I am not sure whether effective or not. Because the publicity of blogs may contain information from wrong points of view or extreme points of view which are harmful to young learners. In order to keep pace with the times, teachers should improve their teaching strategies with new technologies, but they need to be careful, especially for teachers of young learners.
KEY TECHNOLOGY AREA(S): Chemical/Biological Defense; Battlespace Environments; Sensors OBJECTIVE: Develop a Deep Learning (DL) threat detection solution using a fusion of imaging sensors and chemical/biological sensors to detect and locate concealed chemical threats (with potential capabilities for both biological and explosives threats). The developed architecture must be deployable on edge computing platforms for use in real time (better than 60 second detection, 60 frames per second for video sensors) standoff threat detection platforms (50 m) such as Unmanned Aerial Vehicles (UAVs) and Unmanned Ground Vehicles (UGVs). DESCRIPTION: Detection of concealed chemical threats through the development of sensor technology has improved over the last decade. Automated threat identification and location remains a challenge in operational environments. Multi-modal sensing promises to provide greater threat detection capability, as well as identification of threat location and type than individual sensing modalities can provide. Imaging solutions, such as infrared sensors, LIDAR, and RADAR, provide threat detection and location capabilities but cannot adequately differentiate chemical threat types. Chemical sensors provide remarkable capability of threat identification, and general vicinity detection but cannot adequately spatially locate chemical threats. A multi-modal approach to threat detection will provide improved situational awareness and inform appropriate threat response. DL algorithms have significantly improved the ability to autonomously detect a wide range of threats. Recent developments of DL algorithms combine audio and visual representations of a state to increase the correlation of input data to a specific target. Extrapolating from visual and auditory inputs to other sensing modalities will drive automated detection algorithms for chemical/biological threats for environmental awareness of operational environments. Development of a DL architecture that jointly exploits the signature from a chemical sensor with a threat signature from an imaging sensor has multiple benefits over single mode detection modalities by increasing threat detection confidence, as well as threat identification/classification. Additionally, multi-modal DL architectures have shown promise of being less vulnerable to adversarial examples, inputs modified by introducing small perturbations to deliberately fool a target model into outputting incorrect results, bringing an additional layer of security to Department of Defense (DoD) threat detection technologies. Phase I proposals should advance the state-of-the-art of automated chemical threat detection, location, and identification by incorporating multi-modal sensor inputs to a DL detection/identification process. To advance to a Phase II project, performers must demonstrate improved detection/identification rates higher than single mode detection techniques. It is expected that in Phase I and Phase II, performers will utilize Commercial-Off-the-Shelf (COTS) or novel sensor technologies. PHASE I: Develop and test a DL architecture that jointly exploits multi-modal sensor inputs for chemical threat detection and identification. Demonstrate the improved detection performance of the multi-modal DL architecture over single mode DL automated detection algorithms. During the Phase I project, the proof-of-concept demonstration should focus on the discrimination of at least two or more chemical threats with a clear path forward on implementing the DL architecture with low size, weight and power (SWaP) computing hardware for edge computing. Chemical warfare threats of all classes are of interested for threat detection and localization (better than 5 meter accuracy). Examples of chemical threats of interest include, but are not limited to, chlorine; tear gas/pepper spray; and nitrogen oxides. The Phase I deliverable should explain the algorithms tested, software concepts, hardware requirements, results of single mode and multimodal detection tests, and potential use cases and limitations identified within the Chemical and Biological Defense program. PHASE II: Phase II will focus on the development and testing of an embedded multi-modal DL algorithm on a field portable computational platform that can accept multiple sensor inputs. Design of the DL architecture will enable low SWaP requirements of the computation platform to enable ease of deployment to operational environments on small unmanned vehicles (UxV). Evaluation of the multi-modal DL chemical detection algorithms will be extended to multiple threat vectors and demonstrate improved threat detection and identification over single mode DL architectures. Laboratory based characterization and validation of the embedded DL algorithm will be required for a successful completion of Phase II. Technical demonstration and validation of the developed technology in operationally relevant environments will take place with government personnel. PHASE III: The expected Phase II end-product is a well-designed, deployable edge computing device with an embedded DL algorithm trained for detection of chemical threats that can be used on ground and aerial vehicles. Follow-on government and civilian activities are expected to be pursued by the offeror. Transition of the developed technology will require refined algorithm training and testing to optimize the threat detection capability for the chemical threats of concern, as well as extending the number of trained threats and modalities that can be identified. Edge case testing will also be explored and defined. PHASE III DUAL USE APPLICATIONS: Multi-modal target discrimination DL algorithms can support and enhance medical diagnostic applications for increased prognostic assurance. Additionally, leveraging multiple sensor inputs improves perception of a vehicle’s immediate environment. REFERENCES: 1. Zhang, Shiqing, et al. "Multimodal deep convolutional neural network for audio-visual emotion recognition." Proceedings of the 2016 ACM on International Conference on Multimedia Retrieval. 2016. 2. Alshemali, Basemah, and Jugal Kalita. "Improving the reliability of deep neural networks in NLP: A review." Knowledge-Based Systems 191 (2020): 105210. 3. Ortega, Juan DS, et al. "Multimodal fusion with deep neural networks for audio-video emotion recognition." arXiv preprint arXiv:1907.03196 (2019). 4. Le, Minh Hung, et al. "Automated diagnosis of prostate cancer in multi-parametric MRI based on multimodal convolutional neural networks." Physics in Medicine & Biology 62.16 (2017): 6497. 5. Giering, Michael, Vivek Venugopalan, and Kishore Reddy. "Multi-modal sensor registration for vehicle perception via deep neural networks." 2015 IEEE High Performance Extreme Computing Conference (HPEC). IEEE, 2015.
Novel rational drug design strategies with potential to revolutionize malaria chemotherapy. Muregi, F. W. Kirira, P. G. MetadataShow full item record Efforts to develop an effective malaria vaccine are yet to be successful and thus chemotherapy remains the mainstay of malaria control strategy. Plasmodium falciparum, the parasite that causes about 90% of all global malaria cases is increasingly becoming resistant to most antimalarial drugs in clinical use. This dire situation is aggravated by reports from Southeast Asia, of the parasite becoming resistant to the "magic bullet" artemisinins, the last line of defense in malaria chemotherapy. Drug development is a laborious and time consuming process, and thus antimalarial drug discovery approaches currently being deployed largely include optimization of therapy with available drugs--including combination therapy and developing analogues of the existing drugs. However, the latter strategy may be hampered by crossresistance, since agents that are closely related chemically may share similar mechanisms of action and/or targets. This may render new drugs ineffective even before they are brought to clinical use. Evaluation of drug-resistance reversers (chemosensitizers) against quinoline-based drugs such as chloroquine and mefloquine is another approach that is being explored. Recently, evaluation of new chemotherapeutic targets is gaining new impetus as knowledge of malaria parasite biology expands. Also, single but hybrid molecules with dual functionality and/or targets have been developed through rational drug design approach, termed as "covalent bitherapy". Since desperate times call for radical measures, this review aims to explore novel rational drug-design strategies potentially capable of revolutionizing malaria therapy. We thus explore malaria apoptosis machinery as a novel drug target, and also discuss the potential of hybrid molecules as well as prodrugs and double prodrugs in malaria chemotherapy.
Generally speaking, the nature of the work of journalists is similar to that of historians. Both collect facts, verify them and present news and insights that are based on the accumulated facts. That’s why newspapers are considered a great source of history. Sometimes an article penned by a journalist goes on to be considered a historical record of itself. However, there are some important differences between the two professions. The first is that journalists work in the present, while historians work in the past. Yet interestingly, both are capable of predicting the future. Another difference is that news journalists are required to record facts objectively, while historians often include their own points of view and analysis. This is the reason why history often presents us with varying accounts of the same event. The final difference is that historians have the benefit of hindsight to assist with their research, while journalists are limited to the information they are able to obtain under very tight time constraints. Historians are at greater liberty to include their opinions, whereas news journalists should avoid doing so at all costs. Therefore, when reading an article by a historian in a newspaper or magazine, be aware that some opinions may be being presented as facts.
In general, the most important advantage of investing in bonds is that they are relatively less risky than shares (stocks). In case of bankruptcy, a company must first repay bondholders and creditors and only then repay shareholders. Of course, this lower risk also has a disadvantage: the risk premium linked to bonds is lower, which causes their expected return to be lower than that of shares over the long term. This means that if a company does well, the returns you enjoy with bonds probably aren’t going to be as high as the returns from shares. Bonds pay a set interest rate, while the value of shares grows as the value of a company grows. There are two ways that you can achieve a return investing in bonds: This is the return that is obtained from the periodic interest payments. This is the return that is obtained when the market value of the bond increases. Reasons for this can be: Note: As discussed above, the price return also can be negative. For instance, if the credit risk increases or interest rates increase, the price return could be negative. Source: VanEck. The figure only considers the factors interest rates, price level and bond yields and does not take into account other criteria that could potentially negatively influence the bond price.
Electronic products include assembled PCBs, enclosures, and cable assemblies connecting their different parts. USB, Ethernet, CAN bus, and RF assemblies have cables and connectors. Many cables in a product are bound together to form harnesses. Harnesses are common in cars and industrial control systems. Power and signal cables are harnessed separately to avoid interference between them. From a cable assembly standpoint, as a designer, you need to choose the readily available components. This practice reduces preproduction and production lead times. It also provides insights between cost and performance trade-offs so that you could take quick PCB design-related decisions. Power cables typically have the cables and connectors or lugs as terminations. In power cables, the power and current ratings are important. And the wire gauge will depend on the current. For instance, 5 V is given at one end of the cable, which carries a current of 1 A and has a resistance of 1 ohm. The voltage drop across the cable will be 1 V. Therefore, at the other end, the voltage seen will be 5-1, equivalent to 4 V. This may not be acceptable in most applications; the power loss in the cable will be 1 W. To reduce the voltage drop and power loss, the cross-sectional area of the cable should be increased to reduce the resistance. The resistance of power cables should be typically in milliohms. An example of a communication cable is a USB cable. The parameters of a communication cable include the operating frequency, the cable impedance (typically either 50 or 90 ohms), types of shielding and whether the cable is twisted or untwisted, and types of connectors. What is a cable assembly? A cable assembly is a bunch of wires or cables grouped by a heavy-duty thermoplastic, thermoplastic rubber, or vinyl material sheath. Every cable assembly is shielded by a sheath material such as PVC, fluorocarbons, and elastomers to protect the operating environment. It also makes it more organized when in use. Cable assemblies typically have connectors at each end of the cable. What’s the purpose of a cable assembly? Cable assemblies are built to shield the interior wires or cables from heat, friction, moisture, abrasion, compression, etc. They are available in different shapes and sizes and designed based on the operating environment. Specifications for a cable assembly - Operating frequency: Operating frequency depends upon the cable size. A larger diameter cable will not support high frequencies but a small diameter cable will. - Current and voltage rating: The voltage and current ratings of a cable assembly indicate its operating range. - Voltage drop: A voltage drop occurs when the voltage at the end of a cable is lower than that at the beginning. It happens due to increased resistance in a circuit and can be reduced by increasing the diameter of a cable. - Insulation material: Insulation material surrounds the individual conductor wires. It aims to protect wires from mechanical stress and prevent shorts and dielectric breakdown from nearby electrical signals. - Insertion loss: It should be as low as possible because it indicates the ability to carry an RF signal efficiently. - American wire gauge (AWG): AWG is the US standard for measuring the diameter of electrical conductors. AWG gives the estimation of the current-carrying capacity of the wire. The higher the AWG, the thinner the wire will be. - Temperature rating: Temperature variations always affect the electrical performance of the cable assembly. High temperature increases the conductor resistivity leading to copper losses. Temperature changes also affect dielectric properties. That is why dielectric is usually the temperature-limiting factor (for Polyethylene, the temperature range is -65 ºC to +80 ºC and for PTFE, it is -75 ºC to +250 ºC). For extended applications above 150 ºC, solid Teflon cables are not recommended. - Flammability rating: Materials with good flammability values help to minimize the number of toxins released during short circuits. - Ingress protection (IP) rating: IP rating gives the acceptable measurement against obtrusion of solids and liquids into mechanical and electrical enclosures. A higher IP rating indicates better protection against water and other invasive elements. - Voltage standing wave ratio (VSWR): VSWR should be as low as possible. It indicates uniformity along the length of a cable, connection strength, and compensation in the connectors for transitions in the cable or connector interfaces. - Average power handling: It is related to the ability of the cable assembly to dissipate heat generated by resistive and dielectric losses. It is good to have high power handling. - Outgassing: It occurs when trapped gas is released in PCB. This is a matter of concern in outer space where low outgassing materials are required to maintain a clean environment. Selection parameters for a cable assembly - Cable type: When selecting a cable type, review your application’s requirements based on usage and environmental conditions (extreme or even hazardous). For instance, the cable type for an assembly in a military vehicle application will be different from the cable type required in a television studio. Likewise, consider the number of conductors needed and the wire gauges to support the system functionality. A cable can be of two types: signal-carrying and power cables. - Connector type: After selecting the cable, pick the connector type that works best for your application. Again, consider the environment and usage. Simplify this choice by communicating with a vendor who also assembles connectors and offers a variety of options from the top manufacturers. A connector distributor along with cable design and assembly capabilities is a good choice since they will provide a custom end-to-end solution that has been derived from years of experience. - Shielding: EMI caused by noise generated by nearby cables and electronics is responsible for disrupted connections. Communication should be intact even when equipment is handled roughly, and shielding provides that type of protection. Foil shielding offers EMI protection but tears easily, making it undesirable for extreme conditions. Braiding is another option. It is far more durable, allowing easy passage of the signal. - Overmold or cable clamp or heat shrink wrap: Overmold and cable clamps are used to secure connectors and cable junctions. They provide strain relief between the connectors and the cables. A cable clamp is a very basic option but heat shrink is the best. The heat shrink is applied over the connection area and is shrunk to provide a tight fit. It offers moderate strain relief protection and helps with moisture resistance. On the other hand, overmold is a lightweight and heavy-duty molded cover that provides the best strain relief. It is good to choose a vendor that performs overmolding in-house for the quickest turnaround time and quality. - Coupling mechanism: Threaded connectors offer a secure mated connection. Push-together connectors can be mated and unmated easily but generally aren’t as rugged as desired. Bayonet-style connectors ensure the proper alignment of the mating halves. - Quality: IPC-A-610, IPC/WHMA A-620 class 3, and UL certifications are essential. Follow the relevant certifications and standards concerning your region. - DFM: Lead times tend to change based on product availability, design complexity, and application requirements. Vendors with readily available components, custom design expertise, and specification-based assembly provide the fastest delivery. But along with quick delivery, choose a certified and trusted vendor. Quick design tips for a cable assembly Achieving strength and durability at the same time is an intense design challenge when working in a confined environment like a cable assembly. Issues could be inaccurate design, material incompatibility, connector mating, and many more. Some of the best design methods for cable assembly are listed below. - The wire bend radius should be as large as possible. Tight radiuses slow down the manufacturing process, inducing stress on the terminals inside the connectors, hence latent failures. - Always identify the UL style. It helps to figure out the wire flammability value. - Make room for dimensional tolerances. Specify all dimensions from the connector reference plane. - Always add plating (tin, silver, nickel) to the wire to avoid corrosion and oxidation. Plating is also suitable for high-frequency operations. - Avoid direct marking; use shrink tube markers or self-laminating labels. - Always specify the number of contacts. - Use screws to stick to the assembly. - A well-defined coupling mechanism is necessary. Every application comes with unique requirements, and a single cable assembly cannot fulfill all of them. Choose a vendor who will help you sail through these impactful decisions.
Neuroscientists in Bonn and Heidelberg have succeeded in providing new insights into how the brain works. Researchers at the DZNE and the German Cancer Research Center (DKFZ) analyzed tissue samples from mice to identify how two specific proteins, 'CKAMP44' and 'TARP Gamma-8', act upon the brain's memory center. These molecules, which have similar counterparts in humans, affect the connections between nerve cells and influence the transmission of nerve signals into the hippocampus, an area of the brain that plays a significant role in learning processes and the creation of memories. The results of the study have been published in the journal Neuron. Brain function depends on the active communication between nerve cells, known as neurons. For this purpose, neurons are woven together into a dense network where they constantly relay signals to one another. However, neurons do not form direct contacts with each other. Instead they are separated by an extremely narrow gap, known as the synapse. This gap is bridged by 'neurotransmitters', which carry nerve signals from one cell to the next. Specific molecular complexes in the cell's outer shell, so-called 'receptors', receive the signal by binding the neurotransmitters. This triggers an electrical impulse in the receptor-bearing cell and thus the nerve signal has moved on one neuron further. In the current study, a team led by Dr Jakob von Engelhardt focused on the AMPA receptors. These bind the neurotransmitter glutamate and are particularly common in the brain. "We looked at AMPA receptors in an area of the brain, which constitutes the main entrance to the hippocampus," explains von Engelhardt, who works for the DZNE and DKFZ. "The hippocampus is responsible for learning and memory formation. Among other things it processes and combines sensory perception. We therefore asked ourselves how the flow of information into the hippocampus is controlled." A pair of helpers Dr von Engelhardt's research team specifically focused on two protein molecules: 'CKAMP44' and 'TARP Gamma-8'. These proteins are present, along with AMPA receptors, in the 'granule' cells, which are neurons that receive signals from areas outside of the hippocampus. It was already known that these proteins form protein complexes with AMPA receptors. "We have now found out that they exert a significant influence on the functioning of glutamate receptors. Each in its own way, as chemically they are completely different," says the neuroscientist. "We identified that the ability of a nerve cell to receive signals doesn't depend solely on the actual receptors; CKAMP44 and TARP Gamma-8 are just as important. Their function cannot be separated from that of the receptors." This was the result of an analysis in which the researchers compared brain tissue from mice with a natural genotype with brain tissue from genetically modified mice. Neurons in the genetically modified animals were not able to produce either CKAMP44 or TARP Gamma-8 or both. The researchers discovered, among other things, that both proteins promote the transportation of glutamate receptors to the cell surface. "This means they influence how receptive the nerve cell is to incoming signals," says von Engelhardt. However, the number of receptors and thus the signal reception can be altered by neuronal activity. The von Engelhardt group found that in this regard the auxiliary molecules have different effects: TARP Gamma-8 is essential to ensure that more AMPA receptors are integrated into the synapse following a plasticity induction protocol, whereas CKAMP44 plays no role in this context. "Synapses alter their communication depending on their activity. This ability is called plasticity. Some of the changes involved are only temporary, others may last longer," explains von Engelhardt. "TARP Gamma-8 influences long-term plasticity. It makes the cell able to strengthen synaptic communication for a prolonged time-period. The larger the number of receptors on the receiving side of the synapse, the better the neuronal connection." The number of receptors doesn't change suddenly, but remains largely stable for a certain amount of time. "This condition may last for hours, days or even longer. This long-term effect is essential for the creation of memories. We can only remember things if the connections between neurons undergo a long-lasting change," says the scientist. Fast sequence of signals However, CKAMP44 and TARP Gamma-8 also act over shorter periods of time. The research team discovered that the molecules affect how quickly the AMPA receptors return to a receptive state. "If glutamate has docked on to a receptor, it takes a while until the receptor can react to the next neurotransmitter. CKAMP44 lengthens this period. In contrast, TARP Gamma-8 helps the receptor to recover more quickly," says von Engelhardt. Hence, CKAMP44 temporarily weakens the synaptic connection, while TARP Gamma-8 strengthens it. Through the interplay of these proteins the synapse is able to tune its sensitivity to a specific level. This condition can last from milliseconds to a few seconds before the strength of the connection is again adapted. Specialists refer to this as "short-term plasticity". "These molecules ultimately influence how well the nerve cell is able to react to a rapid succession of signals," the scientist summarises the findings. "Such a rapid firing enables neuronal networks to synchronize their activity, which is a common process in the brain." Much to the researchers' surprise, it turned out that the two proteins influence not only the synapse but also the shape of the nerve cells. In the absence of these auxiliary molecules, the neurons have fewer dendrites to establish contact with other nerve cells. "The organism can use CKAMP44 and TARP Gamma-8 molecules to regulate neuronal connections in a number of ways," von Engelhardt says. "This ability depends on the balance between the partners, as to some extent they have a contrary effect. The way in which the neurons of the hippocampus react to signals from other regions of the brain is therefore highly dependent on the presence and the expression ratio of these molecules." Since the two molecules act directly on the structure and function of synapses of granule cells, Jakob von Engelhardt considers it probable that they also have an influence on learning and memory.
In this blog our sustainable building expert Vilma Autio answers questions about the planning and building process of an accessible pilot dry toilet. Why did WASH and Grow! build an accessible dry toilet? The aim of the accessible latrine pilot was to enhance accessibility of the current Mifuko Trust latrine model while at the same time retaining the desirable chamber volume of at least one cubic meter and minimizing price increase. Accessibility is considered a crucial dimension in all human-rights based WASH projects. WASH activities are traditionally designed for ‘average’ persons in communities. Consequently, a large number of people are excluded from many WASH activities and facilities. However, every community is made up of a variety of individuals with a wide range of needs. For example, approximately 15 per cent of the world’s population, 1 billion people, live with disabilities. The majority, about 80 per cent, live in the Global South. Many of them are among the poorest, most marginalised and excluded groups in their communities. Access to safe and clean water and sanitation facilities is a basic right of all people, including children, persons with disabilities and older people. Improved access to WASH activities in community settings has a great impact on the health, hygiene, cleanliness, dignity and quality of life of persons with disabilities and other marginalised groups. Better access to such activities increases independence of marginalised persons while reducing the workload of family members in care-giving tasks. Accessible facilities are easier and safer to reach and use, resulting in a reduction of injuries. An inclusive approach can benefit diverse user groups and can offer a user-friendly and safer option for many community members. How was the planning process? Before revising the plans for the accessible toilet, the project team composed a best practice overview of accessible sanitation solutions by other organizations such as the Global Dry Toilet Association Finland, Disability Partnership Finland and GIZ (German Corporation for International Cooperation). The community members from various households in the project area in Makueni were also consulted. Plans for a fully accessible latrine model were then made based on these findings and they were reviewed by the beneficiaries before beginning the construction. What are the accessibility features of the toilet and which materials are used? The proposed latrine model is fully accessible for people utilizing a wheelchair or crutches as a mobility aid, or people who may need assistance or have otherwise reduced mobility. This also includes elderly people, who may find stairs and high thresholds difficult and may prefer to use a toilet with a seating option instead of the squatting toilet. Likewise people with for example impaired vision may find using this kind of toilet model more comfortable. The main accessibility features of the latrine include the following: • dimensioning spaces so that they cater to wheelchair users or persons who may need an assistant to use the latrine • removing thresholds that may propose a risk of tripping • replacing stairs with a ramp (with limited slope) to ensure easy access to the toilet space • enabling a movable seat option as well as a squatting option • installing proper hand rails where needed • installing wider doors • ensuring that hand washing station is easily reachable to all users The latrine was made using similar construction materials as the previous latrines, compressed earth bricks being the main material for walls, cement for the floor slab and wood and iron sheets for the roof. Materials should be durable and easy to keep clean. Where to build these kind of toilets? Ideally this would be a suitable model for a regular household toilet, however balancing accessibility and affordability is something that needs careful consideration. This kind of fully accessible latrine model is especially suitable for use in public spaces, such as educational and health care institutions and cultural institutions, where there is a need to cater to a large number of users with different abilities and needs. How shall we use the lessons learnt in the future of WASH and Grow!project? The pilot is a model that caters very well to the needs of all kinds of users, even those with severely impaired mobility, and would ideally be replicated for all beneficiary households. However, restraints related to cost and plot size need to be taken into consideration. The pilot can be presented as an example to households to showcase the level of accessibility that can be reached via considerate design and some extra cost. However, the model should be tailored to suit each household’s needs; even though future needs related to accessibility cannot be accurately forecasted as each individual’s abilities may vary greatly during their life due to for example illness, injury or aging. The best option may be to construct future toilets so that they can be utilized by persons of different ages and persons with minor disabilities related to mobility, and that can later be revised to cater to people with more severe disabilities if need be.
से सड़क मार्ग से जुड़ा है साथ ही इस क्षेत्र में मैट्रो भी जल्द ही शुरू होने वाली है। भारतीय रियल्टी केप्रबंध निदेशक और प्रमुख कार्यकारी एस के सयाल ने कहा कि हमें यह सूचित कर बहुत खुशी हो रही है कि हमने ईरॉस के साथ स्मार्ट परियोजना केे लिए करार किया है जो एनसीआर क्षेत्र मेंं आवासीय परियोजना क्षेत्र मेंं एक नया मानक स्थापित करेगी। और तस्वीरें देखिए यहां पर.. जानकारी के मुताबिक, मामला पाली जिले के गणेश नगर का है। यहां शनिवार सुबह 11 बजे मोहम्मद इकबाल टैक्सी खड़ी कर सुनसान इलाके की तरफ जाने लगा तो वहां से गुजर रही मोहल्ले की महिलाओं को उसके चलने के तरीके पर संदेह हुआ। इस पर महिलाओं ने उसे बच्चा चोर समझकर शोर मचा दिया। सेंचुरियन में भी चार तेज़ गेंदबाज करेंगे हमला : गिब्सन खुशहाली और सेक्स एकदूसरे के पूरक निगम क्षेत्र के अधिकांश जल कमल कलश बंद है। गर्मी बढ़ने के साथ ही इनकी उपयोगिता को ध्यान में रखते हुए उसे चालू किया जाएगा। इसके लिए कोशिश शुरू कर दी गई है। बहरहाल अब कोई जवाहरलाल नेहरू का अभिनय करना चाहे तो उसे कोई रोक नहीं सकता है इसलिए आज फूलपुर में राहुल गांधी का भाषण उसी तर्ज़</s>
Definitions of diffusion n. - The act of diffusing, or the state of being diffused; a spreading; extension; dissemination; circulation; dispersion. 2 n. - The act of passing by osmosis through animal membranes, as in the distribution of poisons, gases, etc., through the body. Unlike absorption, diffusion may go on after death, that is, after the blood ceases to circulate. 2 The word "diffusion" uses 9 letters: D F F I I N O S U. No direct anagrams for diffusion found in this word list. Words formed by adding one letter before or after diffusion (in bold), or to dffiinosu in any order: s - diffusions All words formed from diffusion by changing one letter Browse words starting with diffusion by next letter
जा रहे हैं तो इस बात की आशंका बढ़ रही हे कि ये निजी सेनाएं उन क्षेत्रों में खूब उत्पात मचाएंगी जहां उनके नेता को कम वोट मिलने का डर होगा। पर किसे फर्क पड़ता है कि उन दंगों में कितनी बड़ी मात्रा में लोग मारे भी जाते है। देखिए अयोध्या के आसपास क्या हो रहा है? बाबरी मस्जिद विवाद में अभी अदालत का फैसला आना है, पर शिवसैनिकों का जमवाड़ा वहां हो गया है। उन्होंने मुसलमानों और दलितों को इतना डरा दिया है कि वे लोग अपने घरबार छोड़ कर भाग रहे हैं। सिंघु बॉर्डर पर रोके गए किसानों की तरफ से कहा गया कि वह शांतिपूर्ण प्रदर्शन कर रहे हैं और इसे जारी रखेंगे. दूसरी ओर दिल्ली पुलिस ने दिल्ली सरकार से 9 स्टेडियम को अस्थाई जेल बनाने की इजाजत मांगी. प्रदर्शन कर रहे किसानों को गिरफ्तार करके इन जगहों पर लाया जाएगा. होम देश आर्मीनिया और अजरबैजान की लड़ाई में महाशक्तियां दे सकती हैं दखल, अड़ा... कांग्रेस महासचिव प्रियंका गांधी वाड्रा ने मंगलवार को दावा किया कि उत्तर प्रदेश में महिलाओं के खिलाफ अपराध की सैकड़ों घटनाएं होने के बाद भी योगी आदित्यनाथ सरकार की तरफ से महिला सुरक्षा के मुद्दे पर कोई हलचल नहीं दिख रही</s>
कोरोना के चलते पूरे देश में लॉकडाउन जारी है। इस दौरान शराब की दुकानें खोली गईं। शराब की बिक्री पर ७० प्रतिशत स्पेशल कोरोना टैक्स लागू किया गया था। अब ये मामला दिल्ली हाईकोर्ट में पहुंच गया है। दिल्ली हाईकोर्ट ने शराब पर ७० फीसदी कोरोना टैक्स लगाने पर अरविंद केजरीवाल सरकार से जवाब मांगा है। दिल्ली हाईकोर्ट के मुख्य न्यायाधीश डीएन पटेल और जस्टिस हरी शंकर की बेंच ने इस मसले पर सरकार को एक नोटिस जारी की है। जिसमें केजरीवाल सरकार को २९ मई तक जवाब देने का समय दिया गया है। हालांकि, पीटीआई के मुताबिक शुक्रवार को कोर्ट ने सरकार के टैक्स लगाने के फैसले पर फिलहाल रोक लगाने से इनकार कर दिया। कोर्ट ने कहा है कि दिल्ली सरकार का जवाब आने तक इंतजार करें उसके बाद इसपर फैसला किया जाएगा। सरकार के फैसले के खिलाफ याचिका दाखिल करने वाले याचिकाकर्ता ललित वेल्चा ने पीटीआई को बताया कि नोटिस जारी करते हुए अदालत ने कहा कि वह दिल्ली सरकार के जवाब का इंतजार करेंगे और फिलहाल के लिए इस पर अंतरिम स्थगन लगाने से इनकार कर दिया। वहीं दिल्ली सरकार के स्थायी वकील रमेश ने प्रशासन की तरफ से आई नोटिस को स्वीकार किया है। उन्होंने अतिरिक्त टैक्स वसूली को वैध ठहराने का संकेत देते हुए कहा कि इस संबंध में जल्द ही विस्तृत जवाब कोर्ट में दायर किया जाएगा। गौरतलब है कि दिल्ली सरकार ने तीन मई को १५० सरकारी शराब की दुकानों को खोले जाने की मंजूरी दी थी। सभी शराब की दुकानों में भीड़ उमड़ आई थी। ठीक एक दिन बाद सरकार ने शराब पर ७० फीसदी विशेष कोरोना शुल्कलगा दिया था। सरकार के इस फैसले के विरोध में बीते हफ्ते दिल्ली हाईकोर्ट में कई याचिकाएं दाखिल की गई थी। दाखिल याचिका में कहा गया है कि ७० फीसदी शुल्क बढ़ा देना गलत है।
We are often asked whether our 12 volt fridges can be run off the mains power while you're on a campsite hook-up. The short answer is no, not on their own... However, add an MPS box, and that is exactly what happens. Simply connect your 12volt supply and your 240v volt supply to the MPS unit - then plug your fridge into it. The MPS will automatically switch to using mains power to run your fridge whenever it's available. Why would you want to do this? Mainly because it allows your leisure battery to charge fully while you are hooked up to the mains, (without the fridge pinching power at the same time!). It allows your mains charger to operate as effectively as possible. Modern chargers go through several stages while charging up your battery but, if you are drawing power out at the same time as charging, that functionality is less effective. One other benefit of the MPS unit is that, in order to preserve battery power, you might choose to run your fridge 'colder' while on a mains supply - and then raise the thermostat setting when you are off-grid to use less power. - Switch mode, automatic priority for mains operation - Input voltage (AC) 110/230 V - Input voltage (DC) 12/24 V - Output voltage 24 V - Output current 3.00 A - Input frequency 50/60 Hz - IP class IP20 - Energy efficiency ≤87 % - Continuous power 25°C 75.00 W - Operating temperature min 0.00 °C - Operating temperature max 40.00 °C
The numerical description of case-hardening of PM-components requires material parameters in dependency of carbon concentration and porosity. Therefore a method to determine effective diffusion coefficients had to be developed. For quenching simulation the transformation behaviour was measured by quench-dilatometry, the mechanical beahviour was determined by deformation dilatometry and the thermo physical parameters were detected by DSC- and Laser-Flash testing. \|A mechanical surface treatment prior to case hardening enables to adjust a definite carbon profile during carburizing and so surface hardening of PM-components. The built-up numerical tools are able to predict the carbon depth profile and microstructure evolution in good agreement to the experimental results. The residual stress distribution, especially the compressive residual stresses in the surface layer, are overestimated. \| Nevertheless the simulations show the potential to describe case-hardening of graded porous PM-components.
What is it? Allergies are an abnormal response of the immune system. People who have allergies have an immune system that reacts to a usually harmless substance in the environment. This substance (pollen, mold, and animal dander, for example) is called an allergen. Allergies are a very common problem, affecting at least two out of every 10 Americans. Symptoms and Risks Sneezing, itchy, watery eyes, runny nose (clear discharge), coughing, nasal congestion, hives or other skin rash, headache and fatigue are some common symptoms of allergies. These symptoms may be mild to moderate but some allergic reactions can be severe and even life threatening. Skin prick test. This test is done by placing a drop of a solution containing a possible allergen on the skin, and a series of scratches or needle pricks allows the solution to enter the skin. If the skin develops a red, raised itchy area (called a wheal), it usually means that the person is allergic to that allergen. This is called a positive reaction. Other lab testing methods, such as radioallergosorbent testing (RAST) or an immunoassay capture test (ImmunoCAP, UniCAP, or Pharmacia CAP), may be used to provide more information. Your allergy test results may show that allergy treatment is a choice for you. There are several allergy treatment options. Over-the-counter and prescription medications can ease annoying symptoms. Allergy shots also help.
The world view of the people that lived in ancient Finland in pre-written times was animistic. They believed that everything in nature had it´s own soul and spirit. Animals were part of nature and they all had their own soul and spirit living inside them as well. Agriculture arrived at what is now known as Finland about 7000 years ago but even after it´s arrival fishing and hunting remained an important part of the culture. One of the most common elements in old Finnish folk belief was the connection to elements; earth, fire, air, and water. Especially elements of water and the earth were essential because they were closest to humans. Invisible spirits, animals, and plants were divided to represent different elements. Role of the animals was important and they often appear in Finnish folk songs and folk magic. In Finnish ancient pagan world view, väki is a common concept. Väki is the power and energy that flows through in every living being. Each element had its own väki. Men and women had their own väki. Forest had its own väki. Fire, iron and the dead all possessed väki. Väki of the animals was especially strong because their väki was always connected to their living environment. Ants belonged to earth and they represented the spirit of the forest. When the family moved into a new place they lifted stones to see which colored ants there was underneath. These colors had different symbolical meanings. In Finland and in Sweden there was a belief that spirit of a passed away relative could appear as an ant. Snakes were widely worshipped all across ancient Finland and Baltic countries. First literal mentions of keeping pet snakes come from the 16th century. Snakes were fed with cow´s or sheep´s milk and they were considered to be protectors of houses and buildings. Harming snakes was a serious crime. Snakes were sacred animals of the earth goddess Akka. Spring Equinox was known as Matopäivä in ancient Finland, ”day of the snakes”. During Spring Equinox Akka woke up from her winter sleep and snakes woke up from hibernation. They rose from the soil and danced in her honour. During this day it was forbidden for people to do any kind of housework that would implicate to snakes. Deers were connected to the power of the forest. A person who had eaten deer´s brains would see constant nightmares of dark creatures of the forest. Bears were the most worshipped animals in ancient Finland. In some areas, bears were even considered as gods. In Eastern Finland, there was a belief that bear was the sacred ancestor of the clan so the eating bear meat was forbidden. In western Finland bear hunting was common and bear meat was considered as a real treat. There is lots of archaeological evidence of bear cult and bear worship found from Finland. The bear was considered to be both a mythical ancestor and manifestation of the forest. Huntress goddess Mielikki and her husband forest god Tapio both had the ability to shapeshift themselves into bears. When a child dropped their first teeth that teeth were put into the oven and left as a sacrifice for the spider. It was believed that the spider would bring a new teeth rautahammas ”iron teeth” for the child. Passed away relatives could appear in the form of a spider. In the oldest layer of Finnish folklore, frogs were believed to be ancient water spirits. Väki of water was considered to be extremely powerful therefore frogs and fishes were often used in spells. In the Middle Ages frogs (and lizards) were demonized by the Catholic church and there was lots of superstitions and suspicions connected to them. Folk poems of the time describe frogs as spirits of children that were given birth in secret and we're left to marches to die by their mothers. In Finnish folklore, cats were protector spirits of buildings and cats were often kept as pets because they killed rodents. Witch hunts arrived in Finland and Sweden rather late compared to the rest of Europe and in Finland cats never had a reputation of being a witch´s pets so there never was massive cat burnings in Finland like there was in many other parts of Europe. In Finnish mythology, the cat was created in the sauna by tonttu (elf). It was believed that tonttu´s could shapeshift themselves into animals and take forms of a white cat. In some occasions, white cats were believed to be spirits of passed away relatives. Horses had an important role in the agrarian society. The first horse was called Iku-Tihku and it was made by the trolls inside a mountain. Iku-Tihku was made of fire and ice and it was a shamanic traveller. Ancient Finnish tribes believed that the world was made of different levels. Ylinen the upper world where the highest of the spirits lived. Keskinen the Middle world where animals, humans and elemental deities lived and Alinen the underworld, place of the dead. Iku-Tihku could only visit the Middle world during the wintertime because it would melt away in the summer. Trolls used Iku-Tihku as the prototype when they made other horses but they were all made of iron. Most often little birds were seen as good omens. If there was lots of little bird in the yard in the winter that would mean good crop for the next summer. Little birds were believed to be souls of passed away children. When a person took their last breath it was believed that their soul would fly away as a butterfly. Forest rabbits are very common animals in Finland. During winter time their fur changes it´s color to white to blends into the snow. In folklore, rabbit symbolizes intuition, learning, and cleverness. They were common magician´s familiars. Pronounced as Nee-na. Artist, illustrator, writer, watercolorist and a folklorist. Gryffinclaw. Comes from Finland. Likes cats, tea and period dramas. Love fandoms AOGG and Little Women (prefers books over the films). 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The AN/SPS-55 is a solid state, surface search and navigation radar capable of detecting targets from as close in as 50 yards and out to 50 miles and beyond, with good target resolution. The radar set uses several signal processing circuits to improve operation under certain prevailing conditions: Radar Set AN/SPS-55 consists of four major units: antenna group, radar receiver/transmitter, radar set control, and box switch. The system generates two selectable pulse widths. The RF frequency is tunable from 9.05 to 10.0 GHz with a minimum peak power out of 130 kW (measured at the magnetron). The linear array antenna, rotating in azimuth at 16 RPM, forms a beam narrow in azimuth (1.5°) and broad in elevation (-10° to +10°, centered on the horizon). Return target echoes are amplified and detected by the receiver and applied to a PPI. The target information can be displayed in either of two modes, a relative mode where zero degrees bearing on the PPI represents the heading of the ship or a true mode where zero degrees bearing - Fast Time Constant (FTC) circuit - Reduces clutter by displaying only the leading edge of the echo returns. - Sensitivity Time Control (STC) circuit - Reduces receiver gain at close-in ranges where clutter is strong, while allowing a gradual return to normal gain at longer ranges where clutter is less. - Sector Radiate Capability - Allows the operator to limit radiation to a selectable azimuth segment to minimize interference from other ships' radars or ECM equipment. Sources and Resources Maintained by Robert Sherman Originally created by John Pike Updated Tuesday, December 15, 1998 7:42:42 AM
""" Given two arrays, write a function to compute their intersection.""" class Solution: def intersect(self, nums1: List[int], nums2: List[int]) -> List[int]: res = [] x1, x2 = 0, 0 nums1.sort() nums2.sort() while x1 < len(nums1) and x2 < len(nums2): if nums1[x1] == nums2[x2]: res.append(nums1[x1]) x1 += 1 x2 += 1 elif nums1[x1] > nums2[x2]: x2 += 1 else: x1 += 1 return res # Solution 2 import collections res = [] x = collections.Counter(nums2) # or nums1, whatever. for n in nums1: if n in x and x[n] > 0: # it's True even if it's 0 res.append(n) x[n] -= 1 return res
MAYHEM The Solar and Heliospheric Observatory Spacecraft (SOHO) captured this image of a huge, curling solar prominence as it erupted from the sun on July 1, 2002. Prominences are huge clouds of relatively cool, dense plasma suspended in the sun's hot corona. Magnetic fields built up enormous forces that propelled particles out beyond the sun's surface. Emission in this spectral line shows the upper chromosphere at a temperature of about 60,000 degrees Kelvin (107,540 degrees Fahrenheit). NASA said the prominence appears to extend a distance of at least 30 times the diameter of Earth but would not head toward the planet. SOHO is a joint NASA/European Space Agency venture that observes the sun 24 hours a day.
Join the world in the celebration of International Thank You Day on Sunday 11 January 2015! Here are some beautiful Thank You Quotes that you can use in cards or just send via social media! Which one is your favourite? - Saying thank you is more than good manners.� It is good spirituality.� ~Alfred Painter - Kindness is the language which the deaf can hear and the blind can see.� Mark Twain - Unselfish and noble actions are the most radiant pages in the biography of souls.� ~David Thomas - I would maintain that thanks are the highest form of thought, and that gratitude is happiness doubled by wonder.� ~G.K. Chesterton - What we do for ourselves dies with us. What we do for others and the world remains and is immortal.� - Forget injuries, never forget kindnesses.� ~Confucius - Gratitude is the memory of the heart.� ~Jean Baptiste Massieu, translated from French - It’s nice to be important, but it’s more important to be nice.� ~Author Unknown - How beautiful a day can be When kindness touches it! - If the only prayer you said in your whole life was, “thank you,” that would suffice.� - Gratitude is not only the greatest of virtues, but the parent of all the others.� - The roots of all goodness lie in the soil of appreciation for goodness. The Dalai Lama - Feeling gratitude and not expressing it is like wrapping a present and not giving it.� William Arthur Ward Need to say a special Thank You? Send some thank you flowers from serenataflowers.com!Source: quotegarden.com & � write-out-loud.com
When computer scientist Christian Berger’s team sought to get its project about self-driving vehicle algorithms on the road, it faced a daunting obstacle. The scientists, at the University of Gothenburg in Sweden, found an overwhelming number of papers on the topic — more than 10,000 — in a systematic literature review. Investigating them properly would have taken a year, Berger says. Luckily, they had help: a literature-exploration tool powered by artificial intelligence (AI), called Iris.ai. Using a 300-to-500-word description of a researcher’s problem, or the URL of an existing paper, the Berlin-based service returns a map of thousands of matching documents, visually grouped by topic. The results, Berger says, provide “a quick and nevertheless precise overview of what should be relevant to a certain research question”. Iris.ai is among a bevy of new AI-based search tools offering targeted navigation of the knowledge landscape. Such tools include the popular Semantic Scholar, developed by the Allen Institute for Artificial Intelligence in Seattle, Washington, and Microsoft Academic. Although each tool serves a specific niche, they all provide scientists with a different look at the scientific literature than do conventional tools such as PubMed and Google Scholar. Many are helping researchers to validate existing scientific hypotheses. And some, by revealing hidden connections between findings, can even suggest new hypotheses for guiding experiments. Such tools provide “state-of-the-art information retrieval”, says Giovanni Colavizza, a research data scientist at the Alan Turing Institute in London, who studies full-text analysis of scholarly publications. Whereas conventional tools act largely as citation indices, AI-based ones can offer a more penetrating view of the literature, Colavizza says. That said, these tools are often expensive, and limited by the fraction of the scientific literature they search. “They are not meant to give you an exhaustive search,” says Suzanne Fricke, an animal-health librarian at Washington State University in Pullman, who has written a resource review on Semantic Scholar (S. Fricke J. Med. Lib. Assoc. 106, 145–147; 2018). Some, for example, “are meant to get you quickly caught up on a topic, which is why they should be used in conjunction with other tools”. Berger echoes this sentiment: “Blindly using any research engine doesn’t answer every question automatically.” Teaching science to machines AI-based ‘speed-readers’ are useful because the scientific literature is so vast. By one estimate, new papers are published worldwide at a rate of 1 million each year — that’s one every 30 seconds. It is practically impossible for researchers to keep up, even in their own narrow disciplines. So, some seek to computationally tame the flood. The algorithms powering such tools typically perform two functions — they extract scientific content and provide advanced services, such as filtering, ranking and grouping search results. Algorithms extracting scientific content often exploit natural language processing (NLP) techniques, which seek to interpret language as humans use it, Colavizza explains. Developers can use supervised machine learning, for example — which involves ‘tagging’ entities, such as a paper’s authors and references, in training sets to teach algorithms to identify and extract them. To provide more-advanced services, algorithms often construct ‘knowledge graphs’ that detail relationships between the extracted entities and show them to users. For example, the AI could suggest that a drug and a protein are related if they’re mentioned in the same sentence. “The knowledge graph encodes this as an explicit relationship in a database, and not just in a sentence on a document, essentially making it machine readable,” Colavizza says. Iris.ai takes a different approach, Colavizza notes, grouping documents into topics defined by the words they use. Iris.ai trawls the CORE collection, a searchable database of more than 134 million open-access papers, as well as journals to which the user’s library provides access. The tool blends three algorithms to create ‘document fingerprints’ that reflect word-usage frequencies, which are then used to rank papers according to relevance, says Iris.ai chief technology officer Viktor Botev. The result is a map of related papers, but eventually the company plans to supplement those results by identifying hypotheses explored in each paper as well. It is also developing a parallel, blockchain-based effort called Project Aiur, which seeks to use AI to check every aspect of a research paper against other scientific documents, thus validating hypotheses. Colavizza says that tools such as Iris.ai — free for basic queries, but costing upwards of €20,000 (US$23,000) a year for premium access, which allows more-nuanced searches — can accelerate researchers’ entry into new fields. “It facilitates initial exploration of the literature in a domain in which I’m marginally familiar,” he says. Experts seeking deeper insights into their own specialities might consider free AI-powered tools such as Microsoft Academic or Semantic Scholar, Colavizza suggests. Another similar option is Dimensions, a tool whose basic use is free but which costs to search and analyse grant and patent data, as well as to access data using the programmable Dimensions Search Language. (Dimensions is created by technology firm Digital Science, operated by the Holtzbrinck Publishing Group, which also has a majority share in Nature’s publisher.) Semantic Scholar has a browser-based search bar that closely mimics engines such as Google. But it gives more information than Google Scholar to help experts to prioritize results, Colavizza says. That includes popularity metrics, topics such as data sets and methods, and the exact excerpt in which text is cited. “I was very surprised to find that they also capture indirect citations,” Colavizza adds — such as when a method or idea is so well established that researchers don’t refer to its origin. Doug Raymond, Semantic Scholar’s general manager, says that one million people use the service each month. Semantic Scholar uses NLP to extract information while simultaneously building connections to determine whether information is relevant and reputable, Raymond says. It can identify non-obvious connections, such as methodologies in computer science that are relevant to computational biology, he adds, and it can help to identify unsolved problems or important hypotheses to validate or disprove. Currently, Semantic Scholar incorporates more than 40 million documents from computer and biomedical science, and its corpus is growing, says Raymond. “Ultimately, we’d like to incorporate all academic knowledge.” For other tools, such as SourceData from the European Molecular Biology Organization (EMBO) in Heidelberg, Germany, experimental data are a more central concern. As chief editor of Molecular Systems Biology, an EMBO publication, Thomas Lemberger wants to make the data underlying figures easier to find and interrogate. SourceData therefore delves into figures and their captions to list biological objects involved in an experiment, such as small molecules, genes or organisms. It then allows researchers to query those relationships, identifying papers that address the question. For instance, searching, ‘Does insulin affect glucose?’ retrieves ten papers in which the “influence of insulin (molecule) on glucose (molecule) is measured”. SourceData is at an early stage, Lemberger says, having generated a knowledge graph comprising 20,000 experiments that were manually curated during the editing process for roughly 1,000 articles. The online tool is currently limited to querying this data set, but Lemberger and his colleagues are training machine-learning algorithms on it. The SourceData team is also working on a modified neuroscience-focused version of the tool with an interdisciplinary neuroscience consortium led by neurobiologist Matthew Larkum at Humboldt University in Berlin. Elsewhere, IBM Watson Health in Cambridge, Massachusetts, announced in August that it will combine its AI with genomics data from Springer Nature to help oncologists to define treatments. (Nature’s news team is editorially independent of its publisher.) Among those embarking on hypothesis generation are the roughly 20 customers of Euretos, based in Utrecht, the Netherlands. Arie Baak, who co-founded Euretos, explains that the company sells tools to industry and academia, mainly for biomarker and drug-target discovery and validation, for prices he did not disclose. Euretos uses NLP to interpret research papers, but this is secondary to the 200-plus biomedical-data repositories it integrates. To understand them, the tool relies on the many ‘ontologies’ — that is, structured keyword lists — that life scientists have created to define and connect concepts in their subject areas. Baak demonstrates by searching for a signalling protein called CXCL13. Above the resulting publication list are categories such as ‘metabolites’ or ‘diseases’. The screen looks much like Google Scholar or PubMed at this stage, with an ordered list of results. But clicking on a category reveals extra dimensions. Selecting ‘genes’, for instance, pulls up a list of the genes associated with CXCL13, ranked by how many publications mention them; another click brings up diagrams illustrating connections between CXCL13 and other genes. Researchers at the Leiden University Medical Centre (LUMC) in the Netherlands have shown that this approach can yield new hypotheses, identifying candidate diseases that existing drugs might treat. The team presented its results at the Semantic Web Applications and Tools for Health Care and Life Sciences meeting in Rome in December 2017. They have also used Euretos to identify gene-expression changes in a neurological disorder called spinocerebellar ataxia type 3 (L. Toonen et al. Mol. Neurodegener. 13, 31; 2018). So, should researchers worry that AI-based hypothesis generation could put them out of a job? Not according to Colavizza. Hypothesis generation is a “very challenging ambition”, he says, and improvements initially will be incremental. The hypotheses suggested so far are therefore “mostly in the realm of the relatively unsurprising ones”, Colavizza says. That will probably change, of course. But surprising or not, computer-generated hypotheses must still be tested. And that requires human researchers. “One should never believe an auto-generated hypothesis first-hand without investigating the underlying evidence,” warns LUMC researcher Kristina Hettne. “Even though these tools can assist in collecting the known evidence, experimental validation is a must.” Nature 561, 273-274 (2018)
INTRO This is a communicative story creation activity that can be adapted to any holiday or festival in the year. STEP 1 Draw a brainstorm template on the board. (see Below). STEP 2 Brainstorm sets of words or write up pre-prepared sets of words. Actually, I like to mix the two together as it enables me to use target vocabulary and the brainstorm can be funny and spontaneous, warming the students to the activity. reindeer Santa Claus shepherd 3 wise men angel lost hamburger Year 2030 elephant broken heart Bangkok sunrise Xmas Eve Thai dancing carol earthquake broke confused complain disagree STEP 3 You need a set of words per 3 students. Also, remember a good story needs at a minimum 2 characters and a dilemma or bizarre situation. STEP 4 To elicit the vocab I often ask questions like… “What’s the name of a person in this class?” (putting students into the stories adds a lot more fun to the activity) “Give me a number” or ” Give me a negative adjective” Supposing you wanted to do a Christmas lesson you might select or elicit the words as in the sets above. STEP 5 Once you have sets of about 6-8 words form the students into groups of three and tell them to write a short story. I always model a crazy story to get them in the mood. Supposing they had the words below: MIDNIGHT, CARDS, DECORATE, GHOST, FRED FLINSTONE, CHRISTMAS EVE you might tell the story; “At midnight on Christmas Eve Fred Flintstone couldn’t sleep. He remembered he had forgotten to put his cards with his presents under the tree. So he went downstairs and suddenly he was wide awake. There was something white decorating the tree ……..”etc STEP 6 After the stories are finished stick the word sets to the walls around the classroom . One of the authors of the stories will stay to field questions while the other two will walk around the room to ask questions. To make this fun and a game give play money to the people answering questions. The questioners can only ask Yes and No questions and if they receive a “Yes” they will receive some money. It’s a good idea to elicit or drill Yes and No questions first. For example questions that could be asked for the story above might include: Did Fred Flintstone decorate a Christmas tree? Was Fred Flintstone at home? Did this story take place on Christmas Eve? etc. The questioners walk around the class trying to make as much money as possible. Don’t let the answerers reveal the details of their stories. Keep this as a “finale” to the class. Get everyone to sit down and the teacher or a student will read the stories. This is fun because a great deal of suspense should have been generated by the questioning. Past Continuous and “Used to” Exercises 10 Adjectives Exercises Including Adjectives for People and Things 6 Picture-Based Present Continuous Worksheets (PDF) 8 Preposition Exercises for Location, Time and Movement (PDF) 5 Useful Passive Voice Practice worksheets 6 Present Perfect Language and Speaking Worksheets Great Exercises for Conditionals (PDF)
X2 (F2, Cl2, Br2, I2) Apply FAST-ACT powder to fully cover liquid spill and absorb excess liquid. Pressurized cylinder can be used for vapor reduction. Adsorption forming metal haloride. Primary Mechanism Type Metal haloride. Ex. MgCl2 Reaction Rate (Slower to Faster) Reaction Rate: 4 FAST-ACT Application Methods: A. For trace liquid chemical contamination, apply FAST-ACT Powder from either a shaker or pail to the surface to fully absorb the compounds. Apply powder forming a ring around the hazard and then shake the powder directly onto hazard to thoroughly cover the liquid. Carefully Agitate all the powder to ensure all liquid has been adsorbed. B. Alternatively, for trace contamination on a surface, you can utilize a FAST-ACT Decon Mitt. Tear packet at the notch and remove the FAST-ACT Decon Mitt. Unfold mitt and insert hand, tightening the strap. Decontaminate surface by rubbing with pad side to remove liquid contamination. Shake and pat the mitt to release powder from the mitt to the surface. If liquid contamination is still present or suspected, repeat process with a new FAST-ACT Decon Mitt. C. For liquid contamination, directly apply the FAST-ACT Powder from a Shaker or Pail to the liquid to fully absorb the compound ensuring no liquid chemical remains. Apply powder forming a ring around the hazard and then shake the powder directly onto hazard to thoroughly cover the liquid. Carefully agitate all the powder to ensure all liquid has been adsorbed. D. For vapor contamination, utilize a FAST-ACT Pressurized Cylinder to dispense the product into the air space: Shake the FAST-ACT Pressurized Cylinder to loosen the contents. Pull the ring pin. Squeeze the lever and shake the cylinder in up and down motion to ensure maximum discharge of the FAST-ACT powder. Aim the hose and mist all powder in the direction of hazard. If liquid hazard is also present, sweep hose side to side to ensure complete coverage of liquid hazard.
की वजह से वीकेंड के दो दिनों में रिकॉर्ड तादाद में आ रहे सैलानी हफ्ते के अन्य दिनों में यहां आने को तरजीह देंगे। एएसआई के कुछ अफसरों का मानाना है कि चाहे स्टेप टिकटिंग हो या वीकेंड पर प्रवेश शुल्क दोगुना करने का मामला, देशविदेश से आने वाले सैलानियों की भीड़ पर टिकट महंगा होने का कोई असर नहीं होगा। अगर केंद्रीय संस्कृति मंत्री महेश शर्मा के प्रस्ताव को यदि मान लिया गया तो आने वाले समय में कभी भी वीकेंड यानी शनिवार और रविवार को ताजमहल पर प्रवेश शुल्क दोगुना हो सकता है। एएसआई इसे ताजमहल में लगातार बढ़ती जा रही सैलानियों की भीड़ के सही प्रबंधन के लिए जरूरी मान रही है। गौरतलब है कि दिसंबर को ही ताज में स्टेप टिकटिंग यानी मुख्य गुंबद के दीदार के लिए टिकट की कीमतों में इजाफा किया गया था और इसे 200 रुपये कर दिया गया था। पूरे स्कूल को खाली करा लिया गया है। 100 से अधिक बच्चों को स्कूल से निकाला गया है। अस्पताल के मुताबिक सभी छात्राओं की हालत खतरे से बाहर है। मौके पर पुलिस और बचाव दल उपस्थित हैं। राहत कार्य पूरे जोरशोर से चल रहे हैं। जिस कंटेनर से गैस लीक हुआ वह</s>
A database security firm researches new vulnerabilities as they are added to the CVE (Common Vulnerabilities and Exposures) List. This information is used to produce application monitoring and application probing products, including a real-time database intrusion detection tool and an application vulnerability auditing tool. The goal of the software quality effort is to provide an extensible framework to automate the execution and monitoring of vulnerabilities of each new build of the tools, with a variable target run of 20%-100% of the vulnerability test scripts per platform. How can the software quality effort for a database security tool increase test coverage over multiple builds with a dynamic environment consisting of multiple platforms of various patch levels? Implement an automation effort targeting high value processes in order to free up personnel for analysis and increase test coverage for each build with minimal automation script growth. - RTTS used a hybrid approach creating a proprietary Keyword Automation Test Framework (KATF) to automate processes and SQL-based data comparisons between a baseline reference platform (BRP) and the application under test. - Approximately 800 rules were validated utilizing approximately 3000 SQL test scripts against five major database platforms of varying configurations for the application monitoring application. - Approximately 90% of the available exploit data was sampled in a given run of the application monitoring application. - Several vulnerability-auditing tool processes were automated, allowing exact comparisons from backend to front-end of the application, covering approximately 10,000 vulnerabilities for each process. - The KATF was used to vet the consistency of the system for each build of the system compared to a BRP During the framework’s development, each additional test module increased test coverage and freed members of the software quality team to analyze higher priority issues. Each additional module increased test coverage by 10,000 test cases. Furthermore, increasing the number of Test Execution agents used in a full regression run increased test case execution throughput. For users of the automated test suite, minimal training is needed due to the flexible procedure configuration built. A test procedure can be defined by selecting any function, and the procedure can then target multiple test cases by automatically adapting its configuration. - The automated framework increased testing coverage by approximately 20-fold and decreased testing time by a factor of 5. - The software quality team was able to vet each build at a higher level, by letting the automated framework handle lower level regression while the team concentrated on higher priority issues. - Automated data verification between the backend and the front-end was implemented for the application under test along with consistency checking against a baseline reference platform. This allowed rapid localization of defects to specific application areas, resulting in quicker turnaround times for application builds. - Using a large sample size of vulnerability test scripts led to high-confidence-interval results due to greater code coverage.
The 'lollipop plot' above illustrates recurrent (observed in 3 or more out of 4440 TCGA tumor samples from 15 cancer types) and therefore potentially oncogenic missense mutations (click on 'Show Cancer Mutations'). The bar plot below shows the proportion of tumor samples that have any kind of altering mutation(s) in the given protein. Learn more about the integration of cancer data in PhosphoSitePlus: We integrated 4440 tumor samples from 15 cancer types from TCGA (The Cancer Genome Atlas). To retrieve more detailed mutation information, we recommend cBioPortal. We integrated the following cancer types:
Dairy Grazing: Herd Health Veterinary Medicine State Specialist Maintaining herd health and preventing disease is much more cost-effective than treating conditions. A well-designed herd health program minimizes death loss, introduction of new disease and loss of production efficiency due to disease. The best program for ensuring a high-quality health status for the herd on an individual farm will require the use and adaptation of an appropriate combination of the most current herd health techniques and technologies. Risk management plays a vital role in the development and implementation of an effective health program. Risk factors of a disease are those characteristics of the host, environment and pathogens (disease agents) that interact to contribute to the development of the disease. The risk management concept accounts for these complex interactions and serves as the foundation for the formulation and application of control measures (Figure 1). Figure 1. Risk management accounts for risk factors, which are interactions between the host, pathogens and the environment that contribute to development of a disease. Risk management also serves as the foundation for forming and applying control measures for the disease. Environmental risk factors The many environmental risk factors include sanitation, wind, rain, snow, ventilation and air quality, water quality, and population density. These risk factors can have both direct and indirect effects. Certain conditions allow more pathogens to survive in an environment, which increases contamination and raises the level of disease challenge to the animals in that environment. The effects of cold, heat, poor ventilation and crowding impose stress that weakens the animals’ immune response and increases the animals’ susceptibility to disease. Pathogen risk factors Pathogen risk factors include its virulence characteristics (ability to cause disease), reservoir of infection (source of the pathogen), amount of the organism to which the animal is exposed and mode of transmission. Typically, a pathogen causes a characteristic disease, but virulence may vary between strains of the disease agent with one strain causing a more severe level of disease. The ability of a pathogen to spread from animal to animal also can vary with strains. Vaccines may be effective against one particular strain of an agent but not against a different strain. Knowing the reservoir of infection or the source of the pathogen and mode of transmission can assist in formulating control measures. Host risk factors Host risk factors include the animal’s genetics, immune and nutritional status, and age at infection. Colostrum, the first milk a cow produces, provides antibodies against common diseases of newborn calves. The level of colostral immunity in a newborn calf is a major determinant of both resistance to and survival of these diseases. Several intestinal tract diseases that cause diarrhea are common in newborns due to high susceptibility at a young age but are uncommon in older animals because susceptibility decreases with age. However, some level of disease challenge is always present. Figure 2 depicts the concept of disease resistance versus challenge. As long as the level of resistance is maintained above the level of challenge, disease is unlikely to occur (Figure 2A). When the resistance level drops below the challenge level, the risk of disease is high (Figure 2B). The risk of disease is also high when the challenge level rises above the resistance level (Figure 2C). When reduced resistance and increased challenge occur at the same time (Figure 2D), animals are at extreme risk and disease outbreaks are likely. The best possible situation is when the resistance level is raised while, at the same time, the challenge level is lowered (Figure 2E). These guiding principles are used to develop, implement and monitor an effective health program. Work with your veterinarian to establish a vaccination schedule and management practices based on the prevalence and impact of specific diseases in your area. Unless a specific disease problem arises, minimum requirements should suffice. Primary consideration is given to infectious diseases that cause diarrhea, pneumonia, abortion, infertility and sudden death. Your veterinarian can help you determine the timing of initial and booster vaccinations that will maximize protection against the various diseases. Also, establish internal and external parasite control, based on your area, for each of the production stages. Monitor the level of parasitism through routine fecal examination for internal parasites and clinical observation of animals for external parasites, and refine the program as needed. About six weeks after turnout onto pasture is when fecal egg count most closely matches worm burden (the number of worms in the animal). Figure 2. As long as the level of disease resistance is maintained above the level of disease challenge, disease is unlikely to occur. Many management, environmental and physiological factors have a profound effect on the health of the young calf. During their first several months, calves are most susceptible to infectious diseases of the digestive and respiratory tracts. About 75 percent of the mortality of dairy animals less than 1 year old occurs during the first month of life. Calf health begins with prepartum cow care. An adequate dry period (minimum of six weeks) is necessary for the cow to replenish her reserves and store sufficient levels of antibodies in colostrum to protect the calf. Dry-cow vaccinations provide adequate immunization and enhance colostral antibody levels. When choosing which vaccinations to give, consider any specific health problems present on the dairy. Also, adequate bunk space for eating and pen space for lying down are necessary to optimal cow health during dry-cow care. Be sure each cow has at least 30 inches of bunk space and 100 square feet of pen space. Monitor cows during the calving process and help when needed. If maternity pens are used for calving, sanitation is the highest priority. Keep the maternity pens clean and dry. A pen should be used by one animal at a time and must be cleaned and disinfected between each use. Separate maternity pens from other pens and animals, and use them only for calving. Do not house sick animals in the maternity pens. Outside lots used for calving should be well-drained and covered with grass and should provide protection from the weather, such as windbreaks and shade. Wet or muddy areas should be fenced to prevent cows from loitering or calving in these areas. To reduce manure buildup in the maternity lots, leave animals in them for the shortest possible time. Dip the newborn calf’s navel cord in 7 percent iodine immediately after birth. As soon as possible after birth, separate the calf from the cow and place it in a clean, dry, draft-free environment. House calves individually in hutches at least 4 feet apart, or in groups in a well-drained pen. If the calves are housed in groups, each group should have no more than 8 to 10 animals of similar age for the first several weeks of age. Calves should receive 10 percent of body weight of high-quality colostrum within the first 12 hours of life: about 1 gallon for Holstein calves and 3 quarts for Jersey calves. Ideally, the calf should receive 2 quarts of colostrum within 1 hour of birth and an additional 2 quarts within the next 6 to 8 hours. If this is not possible, give the calf the full amount at the initial feeding. A calf that receives the full amount may not want to drink at the next feeding 12 hours later. The producer should not force this feeding but wait another 12 hours, when a vast majority of calves readily drink. Monitor colostrum quality to ensure that newborn calves are receiving high-quality colostrum. Antibody levels in colostrum from older cows are consistently higher than from first-lactation cows. A colostrometer is an excellent instrument for measuring colostrum quality. When using the colostrometer, make sure the colostrum is at room temperature. Producers can maintain a frozen-colostrum bank with colostrum from mature cows in case high-quality colostrum is unavailable. However, several diseases can be transmitted in colostrum. The diseases of major concern are Johne’s (pronounced “Yo-Knees”) disease and bovine leukosis (BLV). Once an animal is infected with either of these diseases, it remains infected for life. There is no prevention and no treatment for these diseases. So, calves should not receive colostrum from cows known to be positive for Johne’s or BLV. During the first month of life, the most common cause of sickness and death is calf scours (diarrhea). Several pathogens, including E. coli, rotavirus, coronavirus, salmonella, coccidia and cryptosporidia, cause calf scours. Although these agents can be present year-round, calf scours can become a significant problem under conditions of crowding, cold stress, inadequate nutrition and poor sanitation. Prevention is key. Adequate high-quality nutrition and clean, dry, draft-free housing are essential components of a prevention program. Specific preventive and treatment measures may be required in some situations. Young calves tend to become ill and die more during cold, wet, windy weather. In a cold environment, calves’ maintenance energy requirements are much higher, so their diet should be adapted. The dietary changes can include increasing fat content of the milk replacer or adding another feeding to the daily schedule. Calves fed milk replacers with less than 20 percent fat are at greater risk during the winter months, if housed in a cold environment. Young calves must be monitored on a regular basis, and the amount of liquid diet should be altered to sustain energy levels during cold conditions. Young calves should be offered a balanced calf starter and water as early as 1 week of age to increase the nutrient density of the total diet without inducing milk scours. Two important health-management practices that should be implemented during the preweaning period are dehorning and removal of extra teats. Calves can be dehorned as early as 2 to 3 weeks of age or as soon as the horn button can be felt. To prevent injury to the calf or the operator, use a restraint device such as a calf cradle or table; local anesthetics and/or analgesics are highly recommended. Electric dehorning is a safe, humane method for dehorning young calves. Proper procedure calls for the surface of the dehorner to be “cherry red” before it is touched to the horn button. The dehorner should be applied to the horn button using steady pressure for about 10 to 15 seconds or until a continuous copper-colored ring is displayed around the base of the horn. This procedure causes minimal pain to the calf and provides rapid destruction of the horn button. Each time a calf is restrained, examine the udder for extra teats. The four regular teats should be symmetrically arranged. Extra teats are usually smaller in size and located close to the main teats. Snip off the extra teats with a pair of scissors, and paint the cut surface with a topical antiseptic. If you are not absolutely sure which teats are the extras, consult your veterinarian. Vaccinations usually are unnecessary in the preweaning stage if the calf has received adequate colostral protection and is kept in a healthy environment. The calf’s immune system does not respond to stimulation, from either disease exposure or vaccination, to the same degree as an adult animal until after 3 months of age. Also, colostral antibodies can interact with vaccines and render most of them ineffective until the calf is more than 3 months old. Specific situations may require certain vaccinations in the preweaning stage. In this case, an intranasal or modified live vaccine (MLV) is preferable. Any vaccine given preweaning should be boostered after the calf reaches 3 months of age. Table 1. Recommended housing specifications for heifers. \|Age group\|\|Maximum head per group\|\|Age spread in group\|\|Area/head\|\|Feed-bunk space length/head\| \|0 to 2 months\|\|1\|\|—\|\|24.0 sq ft\|\|—\| \|2 to 3 months\|\|5\|\|1 week\|\|28.0 sq ft\|\|20 inches\| \|3 to 4 months\|\|10\|\|2 weeks\|\|28.0 sq ft\|\|20 inches\| \|4 to 6 months\|\|20\|\|3 to 4 weeks\|\|37.5 sq ft\|\|27 inches\| Colostral immunity begins to decline between 2 and 6 months of age, and the young calf begins to produce its own immunity. During this transition, calves can go through a period when they are more susceptible to diseases. Weaning often occurs in this transition period. Weaning is one of the most stressful periods in the life of the animal. Given the increased level of stress, waning of colostral protection and increased animal contact due to grouping, take special care during the weaning process to reduce the likelihood of disease outbreaks. Calves should remain in the hutches for two weeks after weaning to promote grain intake and decrease the stress of weaning. Calves can then be moved from the hutches into small groups. Small groups ease the transition from individual housing to group competition. These practices decrease the stress of weaning and help the calves maintain weight gains. Calves should receive their first series of vaccinations or boosters to any vaccines they were given earlier. Refer to the “Health management checklist: 2 to 6 months” for timing of vaccinations. Many vaccines are available to protect dairy replacement animals from diseases. Vaccines commonly used provide protection from brucellosis, infectious bovine rhinotracheitis (IBR), parainfluenza (PI3), bovine virus diarrhea (BVD), bovine respiratory syncytial virus (BRSV), clostridia (blackleg) and leptospirosis. Vaccines also are available to provide protection against pasteurella, hemophilus and pinkeye. Discuss the specific needs of your farm with the herd veterinarian. When administering vaccines, follow the label instructions. Respiratory diseases are the most common health problem in this growth stage. Prevention starts with proper housing and nutrition (energy is of utmost importance). Calves reared in confinement require clean, dry, properly ventilated housing. Provide clean, fresh water and adequate feed-bunk space. Group calves by size and age. Table 1 lists recommended housing specifications. Pasture-rearing calves from weaning to 6 months of age can be successful provided the quantity and quality of available grass is carefully monitored. Pasture alone is generally not recommended for calves less than 4 months old because the composition of pasture often fails to supply adequate nutrients. Calves 4 to 6 months old can graze on pasture with grain supplementation. The amount and blend of grain fed will depend upon the age of the animals and should be balanced to complement the quality of forage being fed. Gastrointestinal parasites can be a serious problem affecting the growth and performance of dairy calves reared on pasture. The eggs of gastrointestinal worms are passed onto the pasture in the feces of infected animals. The eggs hatch in the fecal pats, where the larval form of the worm grows to an infective stage. These infective larvae then move to blades of grass and then are ingested by the animal to complete the life cycle. Parasite control requires the establishment of good parasite management practices to reduce parasite loads in the animal and minimize pasture contamination. Calves less than 1 year old have little or no resistance to internal parasites, so calves should begin a routine deworming program starting at weaning. A deworming program should address the inhibited larval form of Ostertagia (brown stomach worm). The numbers of inhibited larval forms increase during adverse weather conditions such as dry, hot summers and cold winters. For adequate control, appropriate timing and use of deworming products that are effective against the inhibited larval forms are necessary. Both the summer- and winter-inhibited forms are found in Missouri. The major inhibited form will depend on the farm’s location in the state. Consult your veterinarian to find out the inhibited form most common in your area. Strategic deworming involving the use of anthelmintics (dewormers) at selected times combined with various systems of grazing management has been successful. The “treat and move” system involves deworming in late spring before infection pressure is high and then moving the animals to pasture ungrazed by cattle since the previous autumn. In rotational grazing systems, deworming at the start of the rotational pattern effectively “cleans out” the animals so that paddock contamination is reduced. In rotational systems where multiple groups of animals follow one another through the rotation, younger calves should lead, followed by older animals. At the end of the grazing period, pastures can be “dragged” to break up fecal pats and expose eggs and larvae to the effects of drying and sunlight, which aid in reducing contamination. Coccidiosis is another internal parasitic infection that can cause losses in calves. Coccidia are single-cell protozoa that live within the cells of the digestive tract. These organisms can cause extensive damage to the intestinal tract of calves 2 to 12 months of age. Severely infected calves may show signs of bloody diarrhea. Coccidiosis at the subclinical level (undetectable by usual clinical observations) reduces the growth rate of calves. Feeding concentrates, supplements and milk replacer that contain a coccidiostat will help prevent coccidiosis and promote healthy weight gains. Fly control is required during the fly season. It should begin before the fly season to prevent a population buildup and should continue until the first hard freeze. Routine manure and bedding removal help to eliminate fly larval development. The use of sprays on both the premises and livestock provides additional control. Insecticide ear tags and dust bags, along with systemic products, may be included in a fly control program. Animals housed in winter are susceptible to lice infestations. In young calves, severe lice infestations can lead to poor performance and anemia. Control measures for lice include a variety of sprays, dusts and pour-ons. Closely monitor animals for signs of lice, then institute appropriate control measures. Between the ages of 6 and 24 months, the major health problems of heifers on pasture are internal parasites, external parasites and infectious diseases that can cause respiratory and reproductive problems. Maintain internal and external parasite control as described in the previous section. Administer booster vaccinations against respiratory and reproductive diseases (IBR, PI3, BVD, BRSV and leptospirosis). Ideally, these boosters should be given between 60 and 30 days before breeding during a prebreeding examination. If bulls are to be turned in with the cows, be sure they are vaccinated as well. When administering vaccines, follow label instructions under advisement of your veterinarian. The breeding program for replacement heifers is a critical part of a successful dairy operation. Calving heifers by 24 months of age offers several economic advantages. Composite results from studies over the years show lifetime milk yield and lifetime profit are maximized when heifers calve for the first time between 23 and 25 months of age. Increasing age at first calving increases the nonproductive life of the heifer and delays returns of income from milk sales. It also increases the inventory of replacement heifers needed to maintain herd replacement rates. In seasonal breeding programs, replacement heifers must be developed so that their breeding season matches that of the lactating herd. To calve by 24 months of age, a heifer must conceive by 15 months of age. Age and, more important, size are the major factors contributing to the onset of puberty in heifers. Developing heifers to the proper target weight and height by 14 months of age ensures a higher percentage of cycling heifers at the time of breeding. Growth charts for various dairy breeds have been developed that can be used to monitor the progress of replacement heifers and recognize problems in feeding and management while there is still time to take corrective action. In other breeds, a target weight of 65 percent of mature weight at first breeding can be used as a guideline to monitor replacement-heifer development. The decision to use artificial insemination, natural service or a combination of the two needs careful consideration. This decision should be based on the availability of labor and breeding management skills. Before deciding to breed heifers using natural service, explore the disadvantages. Bulls often are difficult to handle, can become dangerous and will increase wear and tear on facilities. They may be subfertile or infertile and can carry venereal diseases. Alternatively, artificial insemination (AI) programs require additional labor and management. A successful AI program requires heifers that are properly developed and cycling, adequate and accurate heat detection and appropriate insemination techniques. Estrus synchronization used in conjunction with AI can improve labor efficiency on most operations. Culling heifers is one of the most difficult and costly decisions facing the dairy producer. Make this decision in a timely manner, however, because delayed culling will increase expenses and lower returns. Respiratory diseases often are the major culprits that result in slowed growth and “poor doers.” Failing to cull these heifers will result in delayed age at breeding, potential difficulty in calving and poor cow performance. The most common physical abnormalities encountered in heifers are freemartinism and white heifer disease. Freemartinism occurs when a heifer is born as a twin with a bull. Developmentally, the male gonads develop before the female reproductive organs. Because of the shared blood supply, the male hormone prevents the proper development of the female reproductive organs. White heifer disease is a genetic disorder that also results in failure of the female reproductive organs to develop. Both conditions produce heifers that lack portions of their reproductive tracts and are infertile. Perform thorough rectal exams when heifers are between 6 and 12 months of age to evaluate the internal reproductive organs and identify these problems. Various injuries and disease processes can render a heifer unfit for the rigors of milk production. These injuries include conformational problems with feet, legs and the mammary gland. Upon diagnosis, heifers should be culled to minimize production costs. An adult-herd health program focuses mainly on maintaining adequate herd immunity through vaccination and minimizing the effects of metabolic diseases, mastitis and reproductive disorders. As with the young stock, establish health procedures based on the prevalence and impact of specific diseases. Fulfill minimum requirements unless a specific disease problem arises. Monitor the incidence of health problems and refine the program as needed. Vaccination schedules in adult dairy herds typically follow one of several protocols. The most common protocol involves administering vaccines either at dry-off or during the dry period, or at both times. An advantage of this protocol is that the animals are in the same stage of production, so booster vaccinations at this time increase the resistance to diseases that may affect reproductive performance in the subsequent pregnancy. Vaccinating at this time also increases the level of immunoglobulins in colostrum, which increases potential protection for newborn calves. A major disadvantage is the challenge of ensuring that all animals receive the health protocol. Cows can be missed unless good records are kept and the protocol is strictly adhered to. Over time, herd immunity decreases, which makes the animals more susceptible to disease challenge. Some producers simply schedule complete herd vaccinations on a specific day. The advantage to this protocol is that all animals are vaccinated. The disadvantage is that the animals are in different stages of production, so increased resistance may not match the disease challenge. Also, a drop in milk production can be expected for a period of several days from the stress of working the animals and the effects of the vaccinations. Vaccinations common to all dairies include infectious bovine rhinotracheitis (IBR), para-influenza (PI3), bovine virus diarrhea (BVD), bovine respiratory syncytial virus (BRSV) and leptospirosis. These vaccines should be administered on at least an annual basis, preferably prior to breeding. Vaccines also are available for a variety of other health problems. For example, scours vaccines are administered to cows to provide mastitis control and colostral protection for calves. The timing of administration is critical to the success of these vaccines. Discuss the specific vaccine needs of your farm with the herd veterinarian. When administering vaccines, follow the label instructions under the advisement of your veterinarian. Metabolic diseases are defined as disorders that are nutritional in origin and often result in acute symptoms that require treatment. Metabolic disorders most often occur from just before calving through peak lactation. The increased susceptibility during this time is associated with changes in metabolism during the transition from the relatively small nutritional demands of the dry period to large nutritional demands with the onset of lactation. Primary threats are milk fever, ketosis and indigestion (lactic acidosis), but grazing herds also need to be protected from grass tetany and bloat. Milk fever occurs at or near calving and is characterized by low blood calcium levels and muscular weakness. Besides the typical “downer cow” presentation, muscular weakness predisposes the cow to several calving-related complications, including prolonged calving, uterine prolapse and retained fetal membranes (afterbirth). Prevention and control centers around restricting calcium intake during the dry period so that calcium mobilization mechanisms in the body remain functional to move calcium from body stores at calving. Keeping calcium intake to less than 20 grams a day is ideal, but formulating diets to meet this requirement is very difficult. Diets with daily calcium intake below 80 to 100 grams a day are successful in minimizing the incidence of milk fever. Such a diet precludes the feeding of minerals containing calcium and feedstuffs known to be high in calcium, such as legumes, during the dry period. Use of anionic salts can help mitigate the effects of high potassium and/or calcium levels in the dry cow diet. Work with your nutritionist if you choose to use these feed additives. Ketosis results from impairment in metabolism of carbohydrates and volatile fatty acids (VFA) that leads to hypoglycemia (low blood sugar). Body fat is mobilized in response to hypoglycemia, and incomplete fat metabolism leads to ketone formation (ketosis). Ketosis is most common four to six weeks after calving when the drain on the cow’s glucose reserves is highest. Thus under- or overconditioned cows with inadequate feed intake following calving are likely candidates. Any condition that leads to reduced or inadequate feed intake ultimately results in ketosis. The use of monensin has proven to decrease the number of clinical and subclinical cases of ketosis in the dairy cow. Indigestion is associated with feed changes such as a switch from concentrate feeds to lush pasture or vice versa. Abrupt dietary changes or consumption of soured feedstuffs alters rumen pH and fermentation, which trigger indigestion. Depending on the abruptness of the change and the volume of feedstuffs consumed, this condition can vary from mild, simple indigestion to the more severe form (lactic acidosis), which can be life threatening. Indigestion can be a common problem in lactating cows when they are fed concentrates in the parlor during milking and then turned to roughages or pasture. This process, often called “slug feeding,” leads to continual fluctuation in ruminal pH and indigestion. The best prevention is feeding-management strategies that make dietary changes gradually. Major dietary transitions, such as switching dry-cow to lactating-cow rations, require an adaptation period of about three weeks. Gradual change from high-roughage to high-concentrate diets allows ruminal bacterial populations to adapt. Feeding rumen buffers such as sodium bicarbonate helps to reduce the risk. Grass tetany, which is potentially fatal, is characterized by low blood magnesium levels and, often, low blood calcium levels. The most common occurrence is in lactating cows shortly after they begin grazing lush, succulent grass pasture. Low levels of magnesium in lush plants and/or the competition for absorption between magnesium and other minerals are thought to cause grass tetany. Heavily fertilized pastures, especially wheat, appear to increase the risk. Dietary supplementation with a magnesium source such as magnesium oxide for cattle on tetany-type pastures is used as a preventive. Bloat is the excessive accumulation of fermentation gases within the rumen and can be in the form of free gas or foam (froth). Frothy bloat occurs in animals consuming a variety of feedstuffs. Lush forages have the potential to cause frothy bloat. The worst offenders include legumes such as alfalfa, sweet clover and red clover as well as lush wheat or ryegrass. Grazing management is important for control of bloat on pastures. Cattle should not be exposed to bloat-causing forages when hungry. Supplement with coarse roughages or grains to reduce intake of the pasture forages. Animals should be turned in to pastures after the dew has evaporated. Limit time on the pastures to less than two hours a day. On severely bloat-prone pastures, add the surfactant poloxalene (for example, Bloat Guard), which is highly effective in reducing losses from bloat. Mastitis is an inflammation of the mammary gland that results from the invasion of pathogenic organisms through the teat streak canal. Mastitis is reported as the most common disease affecting dairy cows worldwide. The National Institute for Research in Dairying (NIRD) and the National Mastitis Council (NMC) have outlined and promoted detailed mastitis control strategies. The major pathogens that cause mastitis are classified as contagious or environmental. Contagious pathogens are spread directly from animal to animal, and transmission of these agents occurs during milking. The most common contagious pathogens are Streptococcus agalactiae (Strep. ag.), Staphylococcus aureus (Staph. aureus) and Mycoplasma. Mycoplasma is very difficult to impossible to treat and most cows found with the organism need to be culled. If you suspect Mycoplasma, alert the lab you use for culturing because special media and conditions are needed to grow the organism, and the organism takes longer (10 to 14 days) to grow than the common bacteria. Environmental pathogens, as the name indicates, are commonly found in the environment. They are transmitted from the environment to the animal and can be spread at any time, not just during milking. The major environmental pathogens include E. coli (coliform), Streptococcus uberis (Strep. uberis) and Streptococcus dysgalactiae (Strep. dysgalactiae). Keeping cows from being exposed to mastitis-causing organisms is impossible. Two major objectives of a mastitis control program are to prevent new infections and to reduce the duration of infections. To accomplish these objectives, many producers have adopted some form of the “five-point plan.” The five-point plan consists of - Developing a proper milking procedure that considers hygiene, - Performing teat dipping and disinfecting at milking, - Maintaining milking machines, - Using dry-cow therapy and treating clinical cases - Culling persistently infected cows from the herd. Proper milking procedure includes premilking udder hygiene, stimulation of milk letdown, efficient milk removal and postmilking teat disinfection. The following principles are important for controlling the spread of contagious pathogens and preventing new infections caused by environmental organisms: - Establish a regular milking schedule in a stress-free environment. Rough handling, loud noises and inconsistent milking intervals induce stress that can counteract the effects of oxytocin and milk letdown. - Check udder and foremilk for mastitis. Look for early signs of mastitis, such as pain, heat or swelling. - Ensure that teats are clean and dry before milking. If udders are excessively dirty, wash and thoroughly dry the udder and teats. Avoid excessive wetting of the udder. Use single-service towels for each cow. Wear sanitized latex gloves during milking. Many producers implement a predip milking procedure to clean and sanitize teats. - Minimize the amount of air drawn into the system during attachment to minimize vacuum fluctuation. Adjust attachment during milking to keep the unit straight and level. - Do not remove the milking unit under vacuum. As soon as the cow is milked out, shut off the vacuum and allow the teat cups to gently fall off the teats. - Use an effective and safe postmilking teat germicide after every milking. Apply the germicide by spraying or dipping, and cover at least the lower half of the teat. Dry teats before exposing to cold and windy conditions. Maintain clean teat-dipping utensils. - Milk current clinical cases and cows with high somatic cell counts (SCC) and chronic clinical mastitis last. - Sample all clinical cases of mastitis. Take a sample from the affected quarter; label the vial with the date, cow number and quarter affected; and put the sample in the freezer or, if culturing for Mycoplasma, the refrigerator. If mastitis cases increase, the samples can be quickly sent off to be cultured. Proper installation, function and maintenance of milking equipment plays an integral role in milking efficiency and has a direct influence on the status of udder health. Guidelines are listed in Chapter 11, Facilities Design, in MU Extension publication M168, Dairy Grazing Manual. The proper management of dry cows is an extremely important component of a mastitis control program. The dry period offers the opportunity to improve udder health while the cow is not lactating. However, the beginning and end of the dry period are times of increased risk of infection. Cessation of hygienic milking practices such as teat dipping allows bacterial populations on teat skin to increase. Studies show that the teat canal is more penetrable early in the dry period and again late during the prepartum period. Marked changes in mammary gland secretions and in concentrations of protective factors during the dry period influence the variation in susceptibility to both environmental and contagious pathogens. Dry-cow therapy is the infusion of long-acting antibiotic preparations into each quarter at dry-off and is an extremely important procedure in a mastitis control program. The use of effective dry-cow products reportedly eliminates 70 to 90 percent of existing infections and reduces the incidence of new infections by 50 to 75 percent. To prevent contaminating the udder and causing infections, maintain strict sanitation during the procedure. Follow these steps to perform dry-cow treatment: - Completely milk out the udder. - Dip or spray all teats with effective germicide. - Disinfect each teat end with individual alcohol-soaked swabs. Swab far teats first and near teats last. Be careful not to touch teat ends after swabbing. - Infuse each quarter with a single-dose syringe of dry-cow preparation. Use the partial insertion technique of syringe cannula (no more than 4 mm). Infuse near teats first and far teats last. - A teat sealant may be used after the antibiotic treatment. Research has shown that for up to 10 to 14 days after dry off, as many as 50 percent of teats may not have fully keratinized, increasing the potential for infection by environmental organisms. If a herd has struggled with high bulk tank somatic cell count (SCC) or cows will be placed in a sacrifice paddock, the use of an internal teat sealant may be advisable. - Dip or spray all teats with effective teat germicide immediately after treatment. Follow all label directions, and observe milk withdrawal times, which are typically 30 to 42 days. Keep records of treatment dates to prevent potential residues in the subsequent lactation. Therapy during lactation Appropriate therapy of mastitis during lactation is another important component of udder health management. With the herd veterinarian, develop a treatment protocol for lactating cows. The level of udder health status and severity of cases are important considerations. The treatment protocol should be well defined and understood by everyone involved. Treatment should consider case characteristics, knowledge of the causative agent, stage of lactation, age of the cow, and duration and severity of the infection. Culling chronic infections The final step of the five-point plan is the selective removal from the herd of cows with chronic udder infections. Culling is the major control procedure for some specific mastitis pathogens, most notably infections with Staph. aureus. Cows infected with this organism have a poor cure rate (15 percent) and serve as a chronic source of infection for the rest of the herd. Most producers interpret this recommendation to mean that cows with recurrent episodes of mastitis should be eliminated. Certain strategies have established that cows having three or more cases of mastitis in a particular lactation be culled. Other strategies for deciding which cows with clinical cases of mastitis to cull involve evaluating other production parameters, such as age, feet and leg condition, milk production and stage of lactation. Available monitoring techniques and establishment of a defined culling program give producers a valuable opportunity to improve udder health by culling. Abortion causes significant economic losses for producers because of extended calving intervals, reduced milk production and loss of calves. Microorganisms that survive in the bloodstream of the cow and cross into the uterus can cause placentitis, or fetal death, and can cause abortion. Abortion events that occur only occasionally and at random are classified as sporadic. Abortion events that result in a high percentage of animals aborting in a short period of time are classified as epizootic. Microorganisms that are common in the environment of cows, such as Actinomyces pyogenes, Escherichia coli, Aspergillus, Bacillus and Streptococcus species, tend to cause sporadic abortion. Thus, reducing the number of microorganisms to which cows are exposed, through a prevention program focused on sanitation, will reduce the risk of sporadic abortion. Enhancing the health status of the cow through proper nutrition and environmental stress management (reduction of heat stress) will also reduce the risk of sporadic abortion. Commonly recognized diseases include Brucellosis, Leptospirosis, Infectious Bovine Rhinotracheitis (IBR) and Bovine Virus Diarrhea (BVD). Prevention of epizootic abortion focuses on proper immunization and disease control measures aimed at the elimination of carrier animals through testing and culling. Consult your veterinarian for more detailed information on disease controls for epizootic abortion. In addition, persistently infected BVD (BVD-PI) has become much better understood and needs to be addressed. (The most common way of testing for BVD-PI is submitting an ear notch from the calf. If BVD-PI is suspected, all calves, including bulls, stillborns, abortions and heifers must be tested. In addition, all newly purchased animals need to be tested.) A less commonly recognized microorganism that can produce sporadic and/or epizootic abortion is Listeria monocytogenes, which is often associated with feeding moldy silage. The newest recognized cause of abortion, discovered in 1984, is Neospora caninum. Neospora is a protozoal organism that infects dogs and is passed in their feces, thus exposing cattle to the organism. A vaccine for prevention of this disease is available, but its effectiveness has not yet been determined. Eliminate cow contact with dog feces. The risk of abortion can be reduced significantly through implementation of control measures that address environmental management aimed at reducing stress; proper nutrition and immunization to maximize immunity; and biosecurity measures focused on sanitation and the prevention of disease entry through new herd additions. Bovine lameness is a multifactorial problem that alters the animal’s gait and reduces performance. Many factors, including nutrition, genetics, facilities, environment and infectious organisms, predispose cattle to lameness. Two of the more commonly observed conditions on today’s dairy farms are laminitis (founder) and digital dermatitis (hairy heel warts). Laminitis, or founder, is a disease condition of the claw. This condition begins with a disturbance in the microcirculation of the foot that leads to inflammatory changes at the hoof soft tissue junction and results in impaired horn production and hemorrhage in the sole and hoof walls, which causes double soles, sole ulcers and abscesses. For diagnostic purposes, laminitis fits into one of three classifications: No immediate signs of lameness Rapid onset of lameness Characteristic deformation of the claw that develops over time The classical cause of laminitis is associated with feeding high levels of carbohydrates (ground grains), which results in rapid fermentation. The faster fermentation increases the level of lactic acid in the rumen, which triggers endotoxin release along with histamine response. All of this results in disturbance in the microcirculation of the foot and produces laminitis. Endotoxemia, which often follows severe mastitis and metritis, is also associated with laminitis. The circumstances that lead to endotoxemia are often observed as acute conditions resulting in severe lameness. Grass founder is a chronic form of laminitis associated with dramatic changes in nutrition, such as from poorly palatable stored winter forage to highly palatable lush spring pasture. Spring pasture is high in protein and soluble carbohydrates, both of which are considered factors that contribute to laminitis. Digital dermatitis, or hairy heel warts, is a contagious superficial inflammation of the heel. Two types of lesions have been observed with this disease. In some cases, the lesions are proliferative with wartlike projections; in other cases, they are more erosive with an ulcerlike appearance. The definitive cause of digital dermatitis has not yet been determined. However, the most reasonable explanation is that dermititis is a multifactorial disease in which spirochetes, together with either bacteria or viruses, develop an opportunistic pattern creating the disease. Foot hygiene is critical in dermatitis prevention and control because cows with clean feet are less likely to contract digital dermatitis. Also, reduction of high-moisture conditions is mandatory. This disease is contagious and can be spread from infected cattle to noninfected cattle, so take extreme care when purchasing new herd additions and ensure that hoof-trimming equipment is sterilized between farms and cows. For treatment recommendations, consult your veterinarian. Biosecurity refers to management practices that reduce the chances of infectious diseases being introduced onto the farm by animals or people. It also refers to practices that reduce the spread of diseases found on the farm. Certain segments of the livestock industry, most notably poultry and swine, have long-established, strict biosecurity plans. Although biosecurity measures are commonly discussed in general terms in the dairy industry, efforts to establish a coordinated biosecurity plan have recently received renewed interest. Establishing an effective biosecurity plan involves the following steps: - Set current and long-term goals. - Assess the risks of introduction or spread of the diseases in question. - Define objectives for control or prevention of the diseases in question. - Outline strategies to meet the defined objectives. - Monitor progress. Assessing the risks relates to the potential level of challenge to the herd. The level of relative herd risk can be classified on a herd basis as a closed, modified-open or open herd. In closed herds, all animals are raised on the premises, with no outside additions. These herds are located in areas of relative isolation with minimal contact with outside animals. Modified-open herds have small numbers of herd additions, such as the purchase of herd bulls or replacement heifers, on an intermittent basis. These herds are located in areas of moderate isolation with potential contact with outside animals from surrounding herds. Open herds have large numbers of outside animals introduced routinely. Open herds are often seen during the start-up phase of an operation, during a herd expansion or in herds with excessively high cull rates. The concept of Hazard Analysis and Critical Control Points (HAACCP) has been used to establish objectives and define strategies in biosecurity plans. HAACCP requires an understanding of disease transmission and identifies specific points at which producers should intervene. Certain strategies are common and often relate to simple, good husbandry practices. Many of these practices have been described in this guide. Reduce the risk of disease transmission on your farm by taking these precautions: - Maintain clean, dry, sanitary environments. - Prevent contamination such as manure on hair coat, feed and water. - Separate animals younger than 1 year of age from the adult herd. - Always work from younger to older animals. - Do not use “waste” feed from older animals to feed younger animals. - Wear clean boots and clothing, especially when working with calves. - Isolate sick animals. - Perform a necropsy on all dead animals. - Dispose of dead animals promptly. Prevent potential introduction of diseases from outside sources by taking these precautions: - Admit animals only from herds with known good health status. - Avoid buying animals from mixed sources. - Isolate new animals for at least 30 days. - Screen new animals for disease during an isolation period. - Transport purchased cattle in farm-owned vehicles if possible. Hired transporters should start with a clean truck. - Limit access to facilities by outsiders. Post warning signs. Johne’s disease and BLV Certain diseases, such as Johne’s disease and bovine leukosis (BLV), require special biosecurity considerations. As stated earlier, Johne’s disease and BLV do not have effective preventive measures such as vaccines, and once an animal is infected, it remains infected for life. Johne’s disease is a bacterial infection that affects the lower gut and causes chronic diarrhea and wasting. Young animals from birth to 6 months are most susceptible to infection. However, the disease has a long incubation period that can last years, and animals do not typically show clinical signs until they are adults. About 1 to 5 percent of infected animals show clinical signs in a given year. As the disease progresses, the organism is shed in the feces in increasing numbers. The organism has been shown to survive in the environment for up to a year. The major mode of transmission of Johne’s disease is fecal contamination from the infected animal. Colostrum and unpasteurized milk, especially from cows in the later stages of the disease, also can harbor the organism and serve as a source of infection. The disease may also be transmitted in utero (from an infected cow to its fetus); therefore, a calf can be born infected. Fecal culturing and serologic blood tests are available for diagnosing Johne’s disease. However, these tests are not foolproof and require careful interpretation. The following list describes major control measures for Johne’s disease: - Prevent infections by closing the herd to animals with unknown Johne’s disease status. - Secure replacements and herd additions from low-risk herds. - Reduce infections by manure management. - Reduce infections by colostrum and milk management. - Reduce infections by management of infected animals. Bovine leukosis (BLV) is a viral infection that affects lymphoid tissues, usually in the gut, uterus, heart, eye, spinal column and lymph nodes. The clinical signs of BLV relate to the tissues and organs affected. Like Johne’s disease, BLV has a long incubation period that can last years. Each year, 1 to 5 percent of infected animals show clinical disease. Clinical cases of BLV are most commonly seen in animals 4 to 8 years of age. BLV is most often transmitted by the transfer of infected lymphocytes (white blood cells) from an infected animal. Bloodsucking insects, multiple-use needles, rectal palpation using a common plastic sleeve and surgical procedures such as dehorning can spread the disease. As with Johne’s disease, BLV can be transmitted in colostrum and milk, and in utero transmission has been reported. Serologic blood tests are available for BLV. As with those for Johne’s disease, these tests require careful interpretation. The following list describes major control measures for BLV: - Prevent infections by single use of instruments and supplies such as sleeves and needles. - Reduce infections by colostrum and milk management. - Secure herd additions from known low-risk sources. - Reduce infections by isolating and segregating infected animals. - Reduce infections by testing and then culling/slaughtering infected animals. - Reduce infections with insect vector control. Growing interests and concerns about Johne’s disease and BLV has led many states, including Missouri, to adopt uniform guidelines for voluntary control programs. Information on these programs is available through your veterinarian. - Bailey, K., M. Bennett, J. Garrett, D. Hardin, J. Hoehne, R. Randle, J. Spain, B. Steevens, and J. Zulovich, eds. 1993. Missouri dairy plan. Columbia, Mo.: University of Missouri Extension. - Bailey, K., J. Garrett, D. Hardin, J. Hoehne, R. Randle, J. Spain, B. Steevens, and J. Zulovich, eds. 1994. Missouri system of dairy heifer production. Columbia, Mo.: University of Missouri Extension. - Greenough, Paul R., and A. David Weaver, eds. 1997. Lameness in cattle, 3rd ed. Philadelphia, Pa.: W.B. Saunders. - Howard, J.L., and R.A. Smith, eds. 1999. Current veterinary therapy 4: Food animal practice. Philadelphia, Pa.: W.B. Saunders. - Radostits, O.M., K.E. Leslie, and J. Fetrow, eds. 1994. Herd health: Food animal production medicine, 2nd ed. Philadelphia, Pa.: W.B. Saunders. - Van Horn, H.H., and C.J. Wilcox. 1992. Large dairy herd management. Champaign, Ill.: American Dairy Science Association. - Youngquist, Robert S., ed. 1997. Current therapy in large animal theriogenology. Philadelphia, Pa.: W.B. Saunders.
Writing is a missionary work. Books can multiply and go where I cannot, traveling the expanse of the globe. They disappear from bookshelves and pass between hands. My written works will live on once I'm gone in a legacy that will never be finished. I'm a missionary through my pen, and this is why I write.
As dogs age, they are more prone to getting lumps and bumps. One of the common types of bumps are lipomas, also sometimes called fatty tumors. While the word “tumors” sounds a bit scary, tumors are simply growths of abnormal tissue. Benign tumors are usually localized, and do not spread to other parts of the body (metastasize), whereas malignant tumors invade local tissue and can spread to other parts of the body. As with most fatty tumors on dogs, lipomas don’t have a clear cause; genetics, hormones, environment, and diet all can have some influence on their development. In this article, we’ll talk about lipomas and similar tumors, their diagnosis, and their treatment. Fatty Tumors On Dogs Lipomas are benign (non-cancerous) tumors made up of adipose (fat) tissue. They usually appear as discrete, soft, lumpy masses just under the surface of the skin and most will move freely when manipulated. Lipomas are generally found on the trunk (shoulders to hips) and near the top of the legs. However, in rare cases, they can also form in the abdomen, where a layer of adipose tissue cushions the abdominal organs. Older, obese female dogs are more likely to develop them. Doberman pinschers, Labrador retrievers, miniature schnauzers, cocker spaniels, Weimaraners, dachshunds, and small terriers are the breeds most at risk of developing lipomas. Most veterinarians will feel fairly confident in diagnosing a lipoma based on the age and breed of the dog, location of the mass, and the way the mass feels while being palpated. However, it is important to get a definitive diagnosis because 10-15% of mast cell tumors, which are malignant tumors, closely resemble lipomas by sight and feel. Since mast cell tumors have a better prognosis the earlier they are found, having every lump and bump checked out will aid in finding any possible malignant tumors that much sooner. Diagnosis of many tumors can be achieved via examination of cells collected from the mass with a procedure called fine needle aspiration (FNA). In this procedure, a needle attached to a syringe is inserted into the mass. The veterinarian will move the needle around to a few different places within the mass while pulling back on the syringe. This creates negative pressure within the syringe, drawing cells from the mass into the needle and syringe. The contents of the syringe are then “shot” onto several microscope slides by drawing back on the syringe and then quickly pressing the plunger. The slides are then stained and examined under a microscope. Since lipomas are composed of adipose (fat) tissue, visualization of this type of tissue on the slide is fairly diagnostic. Adipose tissue has very characteristic large, empty-looking cells, and often the material on the slide itself has a greasy texture to it. Many masses may have more than one type of tissue present, and so one drawback to fine needle aspiration is that it may be possible to miss sampling some cells, leading to a missed diagnosis. Because fine needle aspirates are not 100% accurate or diagnostic, your veterinarian should ask you to monitor the mass closely for any changes in size, appearance, or texture. If those occur, resampling of the mass with fine needle aspiration should be done at a minimum; your veterinarian may recommend a biopsy or complete removal of the tumor instead. Many veterinarians will usually recommend a wait-and-see approach to lipomas. If the mass remains relatively small, slow-growing, and in a location that doesn’t interfere with the dog’s movement, that may not be an unreasonable approach. Of course, if anything changes significantly, your dog should return to the veterinarian for re-evaluation as soon as possible. Another option is to forego the wait-and-see approach and proceed directly to surgical removal. The advantage to going directly to surgery is that the surgery is much easier while the mass is smaller. Many lipomas merge with the healthy fat tissue next to them, which makes it difficult for the surgeon to determine the edges of the tumor and therefore uncertain if they removed all of it. Some surgeons may recommend a weight-loss regimen for the dog starting several weeks before surgery; this may make it easier for the surgeon to visualize the edges of the tumor, ensuring complete removal. Another advantage of proceeding directly to surgery is that benign lipomas may be indistinguishable from the more malignant infiltrative lipomas and liposarcomas, so removing the tumor early on will improve the prognosis, should the tumor turn out to be one of those types of tumors. Infiltrative lipomas and liposarcomas are discussed in more detail later in this article. Surgical removal will also be more strongly recommended for large masses that interfere with the dog’s movement, cause discomfort, or interfere with normal bodily functions. Other treatment options for lipomas such as using steroid injections, liposuction, and laser therapy have been reported in the veterinary literature. The treatments had varying degrees of success and the number of patients in the studies were fairly small, so the jury is still out on adopting any of those options for treatment at this time. There is a rare variant of lipomas found in dachshunds, called diffuse lipomatosis, in which nearly the entire skin is affected, resulting in rolls of fat around the neck and trunk. Unfortunately, there is no treatment for this type of lipoma, though some veterinarians recommend surgical removal of any areas of tumor tissue that interferes with the dog’s quality of life. However, this is only a temporary fix as the tumor tissue will regrow. Infiltrative lipomas are very locally invasive tumors that arise from the fat cells and invade deep tissue such as muscle, nerves, and bone. However, they rarely spread to other sites (metastasize), and so are considered only partially malignant. The tumors appear to be soft, lumpy swellings in the fat layer under the skin, usually on the chest and legs. They are very rare in dogs, but are most common in middle-aged female doberman pinschers, Labrador retrievers, and miniature schnauzers. Diagnosis of these tumors can be difficult since results of a fine needle aspirate often appear the same as the more benign lipomas. The diagnosis comes from advanced imaging (CT or MRI), evidence of deep tissue involvement at the time of surgery for lipoma removal, or from pathology results of the removed tumor. Thus, it may be prudent to consider surgical removal of any lipomas on dogs that have been shown to be most at risk for infiltrative lipomas. Whenever possible due to the location of the tumor, surgical removal is recommended. The surgeon will remove as much of the tumor as possible (debulk the tumor), but due to the infiltrative nature of the tumor, it is nearly impossible to remove all of it. Surgery alone results in a 40% recurrence rate, and half of those cases recur within 8 months. Dogs that are treated with surgery alone lived about 18 months after diagnosis. The exception is if the tumor is on a leg — amputation of the entire limb would likely remove the entire tumor and be considered curative. Radiation therapy is usually recommended in conjunction with surgical debulking of the tumor. Radiation therapy consists of targeted doses of radiation daily for 15-18 treatments. The dogs are under general anesthesia for the 15-30 minutes of treatment, since they need to be absolutely still for correct targeting of the radiation. Side effects are generally mild, and include redness, irritation, and loss of fur in the area being treated. In one published study, 50% of dogs that had surgery followed by radiation therapy survived at least 40 months. In general, over 90% of dogs that have a full course of radiation therapy after surgery are disease free for at least a year. While it is possible to just do radiation therapy without the surgery, it’s generally not recommended. Radiation therapy is more effective when smaller amounts of tumor tissue is present, so debulking the tumor surgically first provides the best results. Chemotherapy is generally not effective for localized tumors such as infiltrative lipomas, and as such, is not usually recommended. In rare cases, a low-dose chemotherapy protocol designed to reduce the formation of new blood vessels may be used to prevent tumor recurrence by limiting new blood supply to the area of the tumor. Liposarcomas are rare malignant tumors of the adipose tissue underneath the skin. They are solitary masses without a clearly defined border. They usually develop on the chest or legs and can be either soft or firm to the touch. Liposarcomas are locally invasive, and may spread (metastasize) to the lungs, liver, spleen, or bones, though metastasis is not as likely with liposarcomas as it is with other cancers. Older male Shetland sheepdogs and beagles are most at risk for liposarcomas. Unfortunately, fine needle aspiration of a malignant liposarcoma usually yields cells that look like a benign lipoma. Thus a biopsy of the mass is usually needed to make a diagnosis; two different types of biopsies can be performed. With a tissue biopsy, your dog is administered a local anesthetic, and a small piece of the lump is removed and sent to the laboratory for analysis. While a definitive diagnosis is very likely with this approach, a drawback is that if the pathology results indicate a malignant growth, another procedure will have to be performed to remove the growth. An excisional biopsy is performed while your dog is under general anesthesia and involves the removal of the entire mass and as much of the surrounding tissue as possible to ensure that all of the tumor has been removed. This approach will yield a definitive diagnosis, and if it is a malignant growth, the pathologist will also comment on whether they believe all the tumor cells have been removed from the surgical site. This is done by evaluating the margins, or edges, of the removed tumor, looking for tumor cells among the normal tissue. A recent study showed that a liposarcoma diagnosis can also be made using a CT scan of the mass. A CT scan is basically a 3D X-ray of the area of interest. Because the dog cannot move during the time it takes to run the scan (between 20 and 60 minutes), general anesthesia is used to keep the dog still. Many specialty and referral veterinary practices have a CT scanner on site. Similar to infiltrative lipomas, surgical removal or debulking of the mass is the treatment of choice. Dogs who are diagnosed with liposarcoma by excisional biopsy but do not have the mass removed live an average of 183 days, or about six months. If the surgeon is unable to remove all of the tumor because of its location, survival time averages 649 days, or about a year and a half. If the surgeon was able to remove all of the tumor (called having “clean margins”), the average survival time increases to 1188 days, or over three years. Some studies are being done combining radiation therapy with surgical debulking of liposarcomas, particularly in cases where the surgeon was unable to achieve clean margins. Final results are still pending, but preliminary work appears promising. While jumping straight to surgical removal for presumed lipomas is probably not realistic for most owners, and may not be in the best interests of every dog, it is certainly important to make sure to have your veterinarian check lumps and bumps with a fine needle aspirate. Malignant mast cell tumors can look similar to lipomas in appearance, and some veterinarians have been caught off guard with assuming a dog has yet another lipoma only to find out differently when a fine needle aspirate was performed. If your dog is in one of the risk groups for infiltrative lipoma or liposarcoma, then keep in mind that a fine needle aspirate is likely not going to diagnose those more serious tumors, and at the very least, a tissue biopsy should be performed of any new masses. With careful monitoring of your dog’s lumps and bumps, you and your veterinarian can work together to keep your dog healthy for as long as possible.
Succubi, like the young princess Astarotte “Lotte” Ygvar, require the life seed from men to survive, replenish their magic, and continue the royal lineage of the magical realm. This means succubi are required to keep a harem of men close at hand. Ironically, Lotte despises men, which will put her life at risk once she matures. To convince her to fulfill her duties, one of her attendants, Judith Snorrevik, goes to the human realm to find a human male whom Lotte can tolerate. Judith returns with 23-year-old Naoya Touhara, a single father who unfortunately leaves his daughter, Asuha, behind in the human realm. As the first member of Lotte’s harem, Naoya quickly adapts to this new environment, serving the princess to make her happy, rather than viewing her with sexual intent. Unfortunately, when his daughter is allowed to arrive in the magical realm, Naoya’s relationship quickly worsens with Lotte. Even so, he strives to patch up their relationship. It soon becomes clear, however, that Naoya’s presence in the magical realm is more than just mere coincidence. As he develops his bond with Lotte, fate begins to pull together the connections that tie him and everyone else within this enchanting world. [Written by MAL Rewrite] Alternative Titles: Astarotte no Omocha!, Lotte no Omocha!, アスタロッテのおもちゃ！
पर कब्जा करके भेरू जी की जगह दबा दी थी। इसकी शिकायत कलेक्टर को थी। जिस पर राजस्व टीम मौके पर आई थी। इसी दौरान कंवरलाल दांगी, गोवर्धन गोरिलाल, रमेश, संजय, गिरिराज आदि ने हम पर पत्थर लाठी ओर धारदार हथियार से हमला कर दिया। वहीं संजय दांगी ने बतया की यह जमीन वर्ष 2000 में 9000 वर्गफिट फिट खरीदी थी। यहां खाली जगह थी। इन्होंने 2008 में यहां भेरूजी बैठा दिए, तभी से विवाद चल रहा है। जबकि इनके भेरूजी गार्डन के यहां बरगद के पेड़ के यहां है। संजय दांगी ने बताया कि यहा? मेरी निजी जमीन है । एनसीएल सिंगरौली के चीफ मैनेजर अरविंद कुमार सिन्हा की हत्या पतिपत्नी के रिश्तों में पैदा हुई कड़वाहट का परिणाम है। यह बात उनकी पत्नी गुंजा सिन्हा ने पुलिस को बतायी। पुलिस की टीम ने शनिवार को रांची के कोकर इलाके में स्थित अरविंद सिन्हा के आवास पर उनकी पत्नी गुंजा सिन्हा से पूछताछ की। इसी दौरान पत्नी ने अपना अपराध स्वीकार कर लिया। पहली बार त्रिस्तरीय पंचायत चुनाव में वोटिग करने का अवसर प्राप्त हुआ। कई बार लगा भी कि कोरोना संक्रमण फैलने से बूथों पर डर बना हुआ है, लेकिन इन सब डर को खत्म कर हमने उत्साह</s>
CBSE Class 10 Sample Paper for 2020 Boards - Maths Standard Class 10 Solutions of Sample Papers for Class 10 Boards ## If sin π + cos π =√3, then prove that tan π + cot π = 1 ### Transcript Question 32 (OR 1st question) If sin π + cos π =β3, then prove that tan π + cot π = 1 sin π + cos π =β3 Squaring both sides (sin π + cos π)2 = (β3)^2 (sin π + cos π)2 = 3 sin2 π + cos2 π + 2 cos ΞΈ sin ΞΈ = 3 Putting sin2 π + cos2 π = 1 1 + 2 cos ΞΈ sin ΞΈ = 3 2 cos ΞΈ sin ΞΈ = 3 β 1 2 cos ΞΈ sin ΞΈ = 2 cos ΞΈ sin ΞΈ = 1 We have to prove tan π + cot π = 1 Solving LHS tan π + cot π = sinβ‘π/cosβ‘π +cosβ‘π/sinβ‘π = (sin^2β‘π + cos^2β‘π)/(cosβ‘π sinβ‘π ) Putting sin2 π + cos2 π = 1 = 1/(cosβ‘π sinβ‘π ) From (1): cos ΞΈ sin ΞΈ = 1 = 1/1 = 1 = RHS Since LHS = RHS Hecne proved
# 16. 3Sum Closest Given an integer array `nums` of length `n` and an integer `target`, find three integers in `nums` such that the sum is closest to `target`. Return the sum of the three integers. You may assume that each input would have exactly one solution. Example 1: ``````Input: nums = [-1,2,1,-4], target = 1 Output: 2 Explanation: The sum that is closest to the target is 2. (-1 + 2 + 1 = 2). `````` Example 2: ``````Input: nums = [0,0,0], target = 1 Output: 0 Explanation: The sum that is closest to the target is 0. (0 + 0 + 0 = 0). `````` Constraints: • `3 <= nums.length <= 500` • `-1000 <= nums[i] <= 1000` • `-104 <= target <= 104` ``````class Solution { public: int threeSumClosest(vector<int>& nums, int target) { int closest = nums[0] + nums[1] + nums[2], n = nums.size(); int diff = abs(closest - target); sort(nums.begin(), nums.end()); for (int i = 0; i < n - 2; ++i) { if (i > 0 && nums[i] == nums[i - 1]) continue; int left = i + 1, right = n - 1; while (left < right) { int sum = nums[i] + nums[left] + nums[right]; int newDiff = abs(sum - target); if (diff > newDiff) { diff = newDiff; closest = sum; } if (sum < target) ++left; else --right; } } return closest; } }; `````` Github 同步地址： https://github.com/grandyang/leetcode/issues/16 3Sum Smaller 3Sum https://leetcode.com/problems/3sum-closest/ https://leetcode.com/problems/3sum-closest/discuss/7883/C%2B%2B-solution-O(n2)-using-sort https://leetcode.com/problems/3sum-closest/discuss/7872/Java-solution-with-O(n2)-for-reference LeetCode All in One 题目讲解汇总(持续更新中…) （欢迎加入博主的知识星球，博主将及时答疑解惑，并分享刷题经验与总结，快快加入吧～） \| Venmo 打赏 —\|— 微信打赏 Venmo 打赏（欢迎加入博主的知识星球，博主将及时答疑解惑，并分享刷题经验与总结，试运营期间前五十位可享受半价优惠～） × Help us with donation
sciencesolve \| Teacher \| (Level 3) Educator Emeritus Posted on De Moivre's theorem is helpful but, to use this theorem, you need to convert the algebraic from of complex number 1 + i into its polar form, using the following formulas, such that: `z = x + iy` `z = sqrt(x^2+y^2)(cos(tan^(-1)(y/x)) + isin (tan^(-1)(y/x)))` Identifying `x = 1` and `y = 1` and reasoning by analogy, yields: `z = sqrt(1^2+1^2)(cos (tan^(-1)(1)) + isin (tan^(-1)(1)))` `z = sqrt(2)(cos (pi/4) + isin (pi/4))` Raising to the given power yields: `z^(1/4) = (sqrt(2))^(1/4)(cos (pi/4) + isin (pi/4))^(1/4)` Using De Moivre's theorem yields: `z^(1/4) = (root(8)(2))(cos ((pi/4 + 2npi)/4) + isin ((pi/4 + 2npi)/4))` `z^(1/4) = (root(8)(2))(cos (pi/16 + npi/2) + isin (pi/16 + npi/2)), k = 0,1,2,3` Hence, evaluating `(1 + i)^(1/4)` yields `z^(1/4) = (root(8)(2))(cos (pi/16 + npi/2) + isin (pi/16 + npi/2)), k = 0,1,2,3.` Sources:
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# Proposition 14 To circumscribe a circle about a given equilateral and equiangular pentagon. Let ABCDE be the given pentagon, which is equilateral and equiangular. It is required to circumscribe a circle about the pentagon ABCDE. I.9 Bisect the angles BCD and CDE by the straight lines CF and DF respectively. Join the straight lines FB, FA, and FE from the point F at which the straight lines meet to the points B, A, and E. As in IV.13 Then in manner similar to the preceding it can be proved that the angles CBA, BAE, and AED are also bisected by the straight lines FB, FA, and FE respectively. I.6 Now, since the angle BCD equals the angle CDE, and the angle FCD is half of the angle BCD, and the angle CDF half of the angle CDE, therefore the angle FCD also equals the angle CDF, so that the side FC also equals the side FD. Similarly it can be proved that each of the straight lines FB, FA, and FE also equals each of the straight lines FC and FD. Therefore the five straight lines FA, FB, FC, FD, and FE equal one another. Therefore the circle described with center F and radius one of the straight lines FA, FB, FC, FD, or FE also passes through the remaining points, and is circumscribed. Let it be circumscribed, and let it be ABCDE. Therefore a circle has been circumscribed about the given equilateral and equiangular pentagon. Q.E.F. ## Guide The method given here to circumscribe a circle about any regular n-gon. Simply bisect two of the angles of the n-gon to find the center of the circle, then choose one of the lines from it to a vertex as the radius. This construction is used in propositions XIII.8 and XIII.18.
अहमदाबाद में आज (मंगलवार) सुबह पाटीदार नेता हार्दिक पटेल एक प्रेस कॉन्फ्रेंस करने वाले हैं। कॉन्फ्रेंस के दौरान हार्दिक कांग्रेस के साथ अपनी डील को जनता के सामने रखेंगे। इस दौरान वह हार्दिक सीडी कांड और उन पर लगे बाकी आरोपों पर भी बोलेंगे। जानकारी के मुताबिक हार्दिक कांग्रेस को समर्थन का एलान भी कर सकते हैं। बताया जा रहा है कि कांग्रेस और पाटीदार नेता हार्दिक पटेल के बीच पर्दे के पीछे बातचीत जरूर हुई है, लेकिन दोनों के बीच अभी तक कोई डील नहीं हुई है। इस कॉन्फ्रेंस के जरिए हार्दिक पास नेताओं की कांग्रेस के साथ हुई बैठक को लेकर भी जानकारी देंगे। वहीं, कांग्रेस ने अपने प्रत्याशियों की दो सूचियां भी जारी कर दी है। अब सबकी निगाहें हार्दिक के प्रेस कॉन्फ्रेंस पर टिकी हुई हैं। सूत्रों के मुताबिक पाटीदार नेता हार्दिक पटेल ने कांग्रेस से टिकट बंटवारे में ज्यादा से ज्यादा पाटीदारों को मौका देने की गुजारिश की है। हार्दिक ने अपने लोगों के लिए नहीं बल्कि खासी कांग्रेसी रहे पाटीदार नेताओं के लिए टिकट मांगा है। हार्दिक ने कांग्रेस से कहा है कि जो पाटीदार नेता लंबे समय से कांग्रेस से जुड़े हुए हैं उन्हें मौका दिया जाएगा तो वे और उनके साथ जुड़े लोग कांग्रेस का जमकर प्रचार करेंगे। हालांकि चर्चा ये भी है कि हार्दिक ने अपने तीन खास लोगों के लिए कांग्रेस से टिकट मांगा है।
primes = {2, 7, 13, 19} set (list = {12}) for i in range(1,n-1): set (k = list[0]) for p in primes: insert (pk) in to list unless (pk) is in list remove list[0] from list return list[0]
The following topics provide step-by-step examples of common deployment scenarios. In the Visual Studio Documentation - Deploying a Windows Application - Guides you through deploying an application to another computer. - Deploying a Web Solution - Guides you through deploying a Web application to a Web server. - Creating and Consuming a Merge Module - Guides you through packaging a component in a merge module and then including the merge module in an installer. - Creating a CAB File - Guides you through distributing an ActiveX control. - Creating a Custom Action - Guides you through creating a custom action to send a user to a Web site following installation. - Passing Data to a Custom Action - Guides you through creating a custom action to pass data entered during installation to a custom action that modifies a configuration file. - Using a Custom Action to Pre-compile an Assembly During Installation - Guides you through creating a custom action to pre-compile an assembly after installation. - Using a Custom Action to Create a Database During Installation - Guides you through creating a custom action to create a database during installation. - Redirecting an Application to Target a Different XML Web Service During Installation - Demonstrates how to create a Web application that can be redirected to target a different XML Web service by using the URL Behavior property, an Installer class, and a Web Setup project. - Visual Studio Walkthroughs - Gives a related list of walkthroughs for all areas of programming in Visual Studio.
चण्डीगढ़। हरियाणा में वर्ष २०१७ के दौरान कुरुक्षेत्र में आयोजित किए गए अन्तर्राष्ट्रीय गीता महोत्सव और सभी जिलों में आयोजित गीता महोत्सवों के आयोजन पर लगभग १९.१७ करोड़ रुपये की राशि खर्च हुई। शहरी स्थानीय निकाय मंत्री कविता जैन ने अन्तर्राष्ट्रीय गीता महोत्सव के आयोजन पर हुए खर्च के सम्बन्ध में पूछे गए एक प्रश्न का जवाब देते हुए कहा कि अन्तर्राष्ट्रीय गीता महोत्सव का आयोजन कुरुक्षेत्र विकास बोर्ड द्वारा और सभी जिलों में गीता महोत्सवों का आयोजन जिला प्रशासन द्वारा किया गया। उन्होंने कहा कि अन्तर्राष्ट्रीय गीता महोत्सव और गीता महोत्सव के दौरान सांस्कृतिक कार्यक्रमों शैक्षणिक एवं खेल प्रतियोगिताओं, राज्य मंडल एवं प्रदर्शनी, प्रचार, वैश्विक गीता पाठ एवं १८००० स्कूली छात्रों द्वारा अष्टादश श्लोकी गीता पाठ, कलाकारों एवं शिल्पकारों के लिए भोजन एवं जलपान, आवास एव बिस्तर, सजावट, परिवहन, अस्थायी विद्युत व्यवस्था, ध्वनि व्यवस्था, फोटोग्राफी एवं वीडियोग्राफी, सोशल मीडिया वैब कास्टिंग, अस्थायी सीसीटीवी की व्यवस्था, सफाई व्यवस्था, सांस्कृतिक कार्यक्रमों के लिए पण्डालों के निर्माण तथा अन्य कार्यों पर यह राशि खर्च की गई। सरकार ने गौवंश को प्लास्टिक और अन्य कचरा खाने से होने वाली बीमारियों व मृत्यु से बचाने के लिए बेसहारा गौवंश को गौशालाओं, नंदीशालाओं एवं गौवंश पुर्नवास केन्द्रों में भेजा जा रहा है। इसके अतिरिक्त, अत्यधिक तापमान से गायों के बचाने के लिए गौशाला में शैड व अन्य बुनियादी ढांचे बनाए जा रहे हैं।पशु पालन एवं डेरी विकास मंत्री ने आज यहां विधानसभा सत्र के दौरान सरकार द्वारा बेसहारा गौवंश को बचाने के लिए किए जा रहे कार्यों के सम्बन्ध में पूछे गए एक प्रश्न का जवाब देते हुए यह जानकारी दी। उन्होंने कहा कि प्रदेश में अक्तूबर,२०१६ से २० फरवरी, २०१८ तक कुल १२१७१२ बेसहारा गौवंश को नजदीकी गौशालाओं, नंदीशालाओं, गौ फाटकों एवं गौवंश पुर्नवास केन्द्रों में स्थानंतरित किया गया है। इसके अतिरिक्त, हरियाणा गौ सेवा आयोग द्वारा वर्ष २०१६-१७ एवं २०१७-१८ में बेसहारा गौवंश की देखभाल के लिए गौशाला में शैड व अन्य बुनियादी ढांचे बनाने के लिए ४०० लाख रुपये की राशि प्रदान की गई है।
Using the case of Chinese visiting scholars at one western Canadian University, this two-phase research project explores how fostering collaboration between international visiting scholars, the host university, and the community promotes internationalization. The first phase examines the impact of the visiting scholars’ social interaction on and off campus on the satisfaction and success of their stay in Canada. Based on these findings, phase two addresses ways the community could benefit from interacting with international visitors. As a result, a partnership model is proposed which connects the interests of the university, international visitors, and the local community and emphasizes mutual benefit, shared learning, cross cultural understanding, collaboration and sustainability. Introduction Many universities have seen an increasing number of Chinese visiting scholars spend a significant amount of time in their institutions (Zweig, Changgui & Rosen, 2004). While universities recognize visiting scholars as an important part of their international activity, little is known about the quality of the social exchange with visiting scholars both on and off campus and the impact of such international programs on personal, social and economic goals of all those participating. Even less is known about the local community’s knowledge and reaction towards visiting scholars and the potential benefits arising from interacting with them. With the death of Mao Zedong in 1976 and the new leadership under Deng Xiaoping, came a major policy shift in China from a focus on political development to one of economic pursuit. Among other things this led to new policies and strategies in the area of higher education. One of the initiatives to support the goal of modernizing the nation was the Chinese visiting scholars program-visiting scholar is a term originally used by the Chinese Government to describe scholars sent abroad to institutions of higher education to further their training instead of studying for degrees. Especially in the early years of this program, it was deemed an efficient way to upgrade credentials and training of existing Faculty members. Thus, upgrading became one of the long-term strategies for development in education. The period abroad generally ranged from several months to 2 years. Later, the concept was broadened to include anyone who studied or conducted research in a foreign university without pursuing a degree. In higher education, it was manifested in a two-way investment: inviting foreign experts to teach in Chinese universities and sending students and staff overseas to learn the “advanced technology mainly from the west” (Europe and North America) (Swieg et al. 2004). The implications for universities are numerous, as are the administrative challenges. Paying attention to the visiting scholars is about making sure we have a good relationship with our Chinese partners including government, business, and the local community. This requires strategic planning, a supportive infrastructure, faculty awareness and buy-in, and a commitment to internationalization in one’s institution that is multi-faceted, coordinated and integrated with the community. Promoting university community engagement with these scholars can contribute to creating a learning community. Further research needs to be undertaken to examine the interaction of visiting scholars and the community as an important element of a university’s internationalization strategy. The current study has been limited to one particular group of visiting scholars focussing on one aspect of their experience-social interaction. The research needs to look beyond the social interaction to include a wider range of experience. Studies of this nature need to extend to visiting scholars and students from other countries and regions. Creative Commons License This work is licensed under a Creative Commons Attribution 3.0 License. Miller, Marilyn Dr. and Blachford, Dongyan R. Dr. "A Model for a Sustainable Partnership: Connecting Chinese Visiting Scholars, the University and the Community," Comparative and International Education / Éducation Comparée et Internationale: Vol. 41 , Article 3. Available at: https://ir.lib.uwo.ca/cie-eci/vol41/iss1/3
# https://www.hackerrank.com/challenges/find-the-merge-point-of-two-joined-linked-lists def findMergeNode(head1, head2): if head1 is None or head2 is None or head1 == head2: return None s, n = set(), head1 while n: s.add(n) n = n.next n = head2 while n: if n in s: return n.data n = n.next return None
# Mass vs. Gravity and what our teachers have told us! by dttubbs Tags: gravity, mass, teachers, told P: 3 It seems that I have uncovered a great contradiction in modern thoughts on gravity. First, 2 statements that teachers have often used: 1) Gravity is dependent on the mass of an object. The higher the mass the stronger the gravitation field. 2) Two objects will fall to the earth with the same acceleration no matter what their mass. These two statement seem to contradict each other. The only possible resolution that i have come up with is that statement 2 is not actually correct. Instead there are slight differences in acceleration but these are not noticeable due to the infinitesimal mass of say a bowling ball and a feather compared to the earth as a whole. Does this mean that if there were another "earth" that had approximately the same mass and was dropped at the same time as the feather and the bowling ball, shouldn't the other "earth" fall at a much greater rate due to the immensely stronger gravitational field as opposed to the bowling ball or feather? I may be totaly out of it here but if anyone can shed some light onto this subject, I believe that it will make a most interesting conversation. Emeritus Sci Advisor PF Gold P: 16,091 The difference is how the various objects affect the earth, not the other way around. In other words, you can't notice the earth falling towards the feather while the feather falls to earth. However, you will notice the first earth falling towards the second earth while the second earth falls towards the first! P: 395 I see what you're saying, but there's an equation that answers your problem dealing with two "earths". Force of gravity = gravity constant[(mass of object1 * mass of object2) / (distance between center of masses)^2] I've forgotten the gravity constant, but a quick serach should be able to locate it. P: 196 Mass vs. Gravity and what our teachers have told us! Quote by dttubbs It seems that I have uncovered a great contradiction in modern thoughts on gravity. First, 2 statements that teachers have often used: 1) Gravity is dependent on the mass of an object. The higher the mass the stronger the gravitation field. 2) Two objects will fall to the earth with the same acceleration no matter what their mass. These two statement seem to contradict each other. The only possible resolution that i have come up with is that statement 2 is not actually correct. Instead there are slight differences in acceleration but these are not noticeable due to the infinitesimal mass of say a bowling ball and a feather compared to the earth as a whole. Does this mean that if there were another "earth" that had approximately the same mass and was dropped at the same time as the feather and the bowling ball, shouldn't the other "earth" fall at a much greater rate due to the immensely stronger gravitational field as opposed to the bowling ball or feather? I may be totaly out of it here but if anyone can shed some light onto this subject, I believe that it will make a most interesting conversation. Both statments are correct. To see how, first consider a mass we will call m1. Then we can write the equation for the gravitational attraction between m1 and the earth: F1 = Gm1Mearth/r^2 By Newton's Second Law: F1 = m1a Substitute this in for F1 in the gravitational equation: m1a = Gm1Mearth/r^2 Notice we can divide m1 out of both sides leaving: a = GMearth/r^2 In other words the acceleration (or the rate at which a body falls) is independent of its mass. P: 20 Quote by geometer Both statments are correct. To see how, first consider a mass we will call m1. Then we can write the equation for the gravitational attraction between m1 and the earth: F1 = Gm1Mearth/r^2 By Newton's Second Law: F1 = m1a Substitute this in for F1 in the gravitational equation: m1a = Gm1Mearth/r^2 Notice we can divide m1 out of both sides leaving: a = GMearth/r^2 In other words the acceleration (or the rate at which a body falls) is independent of its mass. #1 That's circular logic. You're using the equations to prove the equations. I think he wants an intuitive explanation of how the equations would still hold under the common ideas he listed. (Which they won't.) #2 Your equation, F = ma = GmM/r^2, only holds if there are two masses in the system. When you introduce a third mass you can no longer claim that the Net Force on m is equal to the force of gravity. The equation you used presupposes that the ONLY force on the object is the force of gravity caused by the mass M The original poster is right, anyway. This statment: Two objects will fall to the earth with the same acceleration no matter what their mass. Would need to be applied to ALL objects. Certainly Mars doesn't fall to the earth with the same acceleration as a bowling ball? Of course not, other forces interfere. In the same vein, dropping a bowling ball and a feather truly AREN'T isolated with the Earth. They each have an effect on each other and the gravity of the sun and the moon effects them and so does every other star in the universe. But these interferences are so small that it is a good general rule that stuff falls towards the earth at the same acceleration. But it doesn't even always hold, in our daily earth-bound lives. Tides for example. They defy the Earth's gravity and don't accelerate towards the Earth at the same rate as a bowling ball. This is because the moon inteferes of course. Tides are proof that statement 2 is only correct under certain circumstances. P: 540 Quote by dttubbs It seems that I have uncovered a great contradiction in modern thoughts on gravity. First, 2 statements that teachers have often used: 1) Gravity is dependent on the mass of an object. The higher the mass the stronger the gravitation field. 2) Two objects will fall to the earth with the same acceleration no matter what their mass. These two statement seem to contradict each other. The only possible resolution that i have come up with is that statement 2 is not actually correct. The higher the masses the higher the gravitational force between them, according to: $$GravitationalForce = \frac{GravitationalConstantMassAMassB}{DistanceBetweenMasses^2}$$ but also, the higher a mass of an object the less a fixed force will acccelerate it according to: $$GravitationalForce = MassObjectAcceleration$$ or $$Acceleration= \frac{GravitationalForce }{MassObject}$$ so on earth, $$GravitationalForceBowlingBall = \frac{GravitationalConstant MassBowlingBallMassEarth}{RadiusEarth^2}$$ and $$AccelerationBowlingBall = \frac{GravittionalForceBowlingBall}{MassBowlingBall}$$ will result in: $$AccelerationBowlingBall = \frac{GravitationalConstant MassBowlingBallMassEarth}{RadiusEarth^2MassBowlingBall}$$ which means: $$AccelerationBowlingBall = \frac{GravitationalConstantMassEarth}{RadiusEarth^2}$$ Thus, as you can see although the force does depend on the mass, the acceleration is independent of the mass, because the higher the mass the less it accelerates if a certain force acts on it. Emeritus PF Gold P: 29,243 Quote by dttubbs It seems that I have uncovered a great contradiction in modern thoughts on gravity. First, 2 statements that teachers have often used: 1) Gravity is dependent on the mass of an object. The higher the mass the stronger the gravitation field. 2) Two objects will fall to the earth with the same acceleration no matter what their mass. These two statement seem to contradict each other. The only possible resolution that i have come up with is that statement 2 is not actually correct. Instead there are slight differences in acceleration but these are not noticeable due to the infinitesimal mass of say a bowling ball and a feather compared to the earth as a whole. Does this mean that if there were another "earth" that had approximately the same mass and was dropped at the same time as the feather and the bowling ball, shouldn't the other "earth" fall at a much greater rate due to the immensely stronger gravitational field as opposed to the bowling ball or feather? I may be totaly out of it here but if anyone can shed some light onto this subject, I believe that it will make a most interesting conversation. What is happening here is that you are using the word "gravity" for two DIFFERENT things. There is a gravitational force, which is the WEIGHT, and the gravitational acceleration, which is usually designated as "g" (not "G", which is the universal gravitational constant). The weight W is defined as W = mg. Thus, already you can see it is dependent on the mass in question. However, the gravitational acceleration of that mass is g. It is independent of how large this mass is (at least, within this simple scenario where most terrestrial mechanics are applied). So next time, when you use the word "gravity", try to think what exactly it is that you are using it as. You will learn that in physics, "words" and phrases are ambiguous and vague. It is only when we realize the underlying mathematical description of it does it now become clear and unambiguous. Zz. Emeritus PF Gold P: 9,542 Quote by dttubbs It seems that I have uncovered a great contradiction in modern thoughts on gravity. First, 2 statements that teachers have often used: 1) Gravity is dependent on the mass of an object. The higher the mass the stronger the gravitation field. 2) Two objects will fall to the earth with the same acceleration no matter what their mass. These two statement seem to contradict each other. They don't contradict each other. The first is a statement about the strength of the gravitational force, or the gravitational field. The second is a statement about acceleration. The first statement is that F=-GmM/r^2. Combine this with Newton's second law, F=ma, and you get the equation ma=-GmM/r^2. If you just divide both sides by m, this simplifies to a=-GM/r^2. So, the acceleration is clearly independent of the mass m. As you can see, the second statement does not only not contradict the first. It is a consequence of the first. (Assuming the validity of Newton's second law, and the equivalence between inertial and gravitational mass). Sci Advisor HW Helper P: 1,772 There is one thing that has (I believe) been overlooked in all the prior posts (it's a long thread, with a lot of good stuff in it, so I apologize if it was already covered): We know that the earth also accelerates (theoreticaly) toward the other object, it is just so small an acceleration that it cannot possibly be measured. Gravitational acceleration always turns out to be equivalent to the gravitational field strength that the object is placed in. Therefore the earth will have a greater acceleration toward the more massive object than it will toward the less massive object. There would then be an a greater net acceleration of the more massive object from the earth's frame of reference. Again, this extra amount is purely theoretical and could not possibly be detected. My pet peeve: I wish teachers and textbooks would stop calling g the "acceleration due to gravity." It makes more sense to call it from the start "gravitational field strength" using the unit N/kg. FOrce of gravity = mg whether it is accelerating or not. N's 2nd law says a = F/m . When F = weight, then a = mg/m = g. P: 395 Wouldn't "dropping" a huge mass on the earth result in faster acceleration though? I thought the two masses would accelerate toward each other. (In this case the moon accelerating toward the earth at the earth's acceleration of gravity rate add to that the earth accelerating toward the moon at the moon's acceleration of gravity.) Emeritus PF Gold P: 29,243 Quote by Chi Meson There is one thing that has (I believe) been overlooked in all the prior posts (it's a long thread, with a lot of good stuff in it, so I apologize if it was already covered): We know that the earth also accelerates (theoreticaly) toward the other object, it is just so small an acceleration that it cannot possibly be measured. Gravitational acceleration always turns out to be equivalent to the gravitational field strength that the object is placed in. Er.... you will notice that in my reply to this thread, I did mention: "It is independent of how large this mass is (at least, within this simple scenario where most terrestrial mechanics are applied)." Considering that this person is already confused between the simple concept of "gravitational acceleration" and "gravitational force", I didn't want to invoke a more complicated discussion of such things. So no, I didn't "overlook" such possibility. I just didn't want to complicate things further. Zz. Sci Advisor HW Helper P: 1,772 Oh, so you did. I was rushing and looking for key words. This is a discussion that comes up every year in my AP class, and I thought it was worth mentioning specifically here. HW Helper P: 1,772 Quote by theCandyman Wouldn't "dropping" a huge mass on the earth result in faster acceleration though? I thought the two masses would accelerate toward each other. (In this case the moon accelerating toward the earth at the earth's acceleration of gravity rate add to that the earth accelerating toward the moon at the moon's acceleration of gravity.) Both of these accelrations are (mostly) centripetal and do not result in either body getting any closer tho the other (assuming circular orbit). P: 2 Quote by Chi Meson We know that the earth also accelerates (theoreticaly) toward the other object, it is just so small an acceleration that it cannot possibly be measured. Gravitational acceleration always turns out to be equivalent to the gravitational field strength that the object is placed in. Therefore the earth will have a greater acceleration toward the more massive object than it will toward the less massive object. You've perfectly described the dilemma I just can't rectify. How can the feather and bowling ball accelerate towards the earth at the same rate, yet the earth accelerate towards the objects at different rates? Does one "really" touch the earth sooner than the other? This is such a fundamental issue, but I can't logically describe why this is OK or consistent. I'm tutoring an English as a Second Language student and am struggling to put these ideas into simple vocabulary and clear examples. The math and the manipulation of equations is not an issue at all. We get that, but I would appreciate a more in depth explanation of this situation or thoughts on how to describe it better. P: 196 Quote by Sneaky You've perfectly described the dilemma I just can't rectify. How can the feather and bowling ball accelerate towards the earth at the same rate, yet the earth accelerate towards the objects at different rates? Does one "really" touch the earth sooner than the other? This is such a fundamental issue, but I can't logically describe why this is OK or consistent. I'm tutoring an English as a Second Language student and am struggling to put these ideas into simple vocabulary and clear examples. The math and the manipulation of equations is not an issue at all. We get that, but I would appreciate a more in depth explanation of this situation or thoughts on how to describe it better. Maybe the best way to explain this is to look back at my post where I did the math. In that post, we looked at the situation from M1's (call M1 a bowling ball just for fun) point of view and we discovered that all objects will fall towards the earth at a constant rate proportional to the earth's mass divided by the distance between the object and the center of the earth squared. But, we can turn the equation around and look at it from the Earth's point of view. We will find that if we substitute Mearth in to the F = ma part of the equation we will be able to divide out the mass of the earth and find that all objects will fall toward the bowling ball at an acceleration independent of their mass, but much much smaller than the bowling ball will fall towards the earth because the bowling is so much less massive than the earth. So, the reason for the different accelerations is that the masses are different. The earth attracts the bowling ball with a force proportional to its mass and the bowling ball attracts the earth with a force prorportional to its mass which is many orders of magnitude less than the earth's mass. Mentor P: 41,579 Quote by Sneaky You've perfectly described the dilemma I just can't rectify. How can the feather and bowling ball accelerate towards the earth at the same rate, yet the earth accelerate towards the objects at different rates? Because the feather and bowling ball are being pulled by the same gravitational field--that of the earth. But the earth is pulled by two different fields: a weak one due to the feather, and a stronger one due to the bowling ball. Does one "really" touch the earth sooner than the other? Of course, here I am talking about the acceleration of each object (feather, bowling ball, earth) with respect to an inertial frame (the center of mass frame). If you literally wanted the acceleration with respect to the earth (including the earth's acceleration) then you'd have to add the two accelerations. In that case, the bowling ball would hit the earth sooner than the feather (ignoring the vastly bigger effect due to air resistance) since the bowling ball accelerates the earth more. But realize this is a ludicrously small correction to the "acceleration due to gravity". g is typically given as 9.8 m/s^2; the additional acceleration due to the earth's response to a 5 kg bowling ball would be about 8.2E-24 m/s^2; and to a 5 g feather, 1/1000 of that. Just an amusing thought experiment. Sci Advisor HW Helper P: 1,772 I can't say it any better than that! HW Helper Thanks P: 10,779 Quote by Sneaky You've perfectly described the dilemma I just can't rectify. How can the feather and bowling ball accelerate towards the earth at the same rate, yet the earth accelerate towards the objects at different rates? Does one "really" touch the earth sooner than the other? This is such a fundamental issue, but I can't logically describe why this is OK or consistent. I'm tutoring an English as a Second Language student and am struggling to put these ideas into simple vocabulary and clear examples. The math and the manipulation of equations is not an issue at all. We get that, but I would appreciate a more in depth explanation of this situation or thoughts on how to describe it better. When two bodies attract each other and move towards each other their centre of mass stays steady. They fall toward the centre of mass and they will reach each other at the centre of mass. The distance between the centres is D. Then the distance of the bigger body from the CM is smaller than that of the smaller body. If the masses are M and m and the distances R and r, respectively, r=DM/(M+m) and R=Dm/(m+M). As the distance between the bodies decreases, the bodies accelerate at different rates as they fall towards each other. $$\frac{d^2r}{dt^2}=\frac{M}{M+m} \frac{d^2D}{dt^2}\mbox{ and } \frac{d^2R}{dt^2}=\frac{m}{M+m}\frac{d^2D}{dt^2}$$. With a little math, we can write the second time derivative of D. For the smaller body: $$m\frac{d^2r}{dt^2}=-\gamma \frac{mM}{D^2}$$ Replacing r with DM/(m+M), $$\frac{mM}{M+m} \frac{d^2D}{dt^2}=-\gamma \frac{mM}{D^2}$$ Rearranging a little: $$\frac{mM}{M+m}\frac{d^2D}{dt^2}=-\gamma\frac{\frac{mM}{M+m}*(m+M)}{D^2}$$ $$\mu=\frac{mM}{M+m}$$ is called "the reduced mass" of m and M. We get an equation of motion which looks like that for a single body of mass $$\mu$$ in the field of a central mass of (m+M). Its acceleration is proportional to the sum of the two masses. In this way, the acceleration of both a feather and the Earth towards their common CM is lower than those of a big stone and Earth - in principle. ehild Related Discussions General Physics 10 Introductory Physics Homework 2 Introductory Physics Homework 3 General Physics 15
The Maintenance Technician is responsible for operation, installation, diagnosis, troubleshooting, repair, preventive maintenance and overall proper function of all types of mechanical equipment, including but not limited to the following pumps, steam turbines, compressors, gear boxes, cooling fans, couplings, seals and all rotating equipment. JOB FUNCTIONS AND KEY RESPONSIBILITIES: MINIMUM ESSENTIAL QUALIFICATIONS: - Completes basic and routine maintenance tasks in support of operations - Conduct all job related tasks in a safe manner; comply with all governmental and corporate regulations (including site-specific procedures) related to occupational safety, employee health and the environment. - Conduct periodic inspection of the facility and report any unsafe condition or, conditions posing a potential conflict with environmental permits or regulations to local management. - Monitor operating conditions, report variances from normal conditions and take appropriate actions to maintain optimum process performance. - Complete all assigned tasks in assigned area(s) of responsibility including those related to compliance assurance. - Complete all deviation reports, including safety, environmental and work orders. - Help operations to prepare portions of the facility or specific items of equipment for maintenance or repair - Participate in emergency response activities - Complete preventative and corrective maintenance job requests - Assemble and repair equipment, while maintaining critical spare parts - Inspect dismantle, repair or replace pipes, valves and fittings - Work with contractors and company employees to complete plant turnarounds - Ability to walk down pipes and vessels using P&IDs', one-line and isometric drawings - Work may involve climbing at heights at or above six feet. - Ability to follow and adhere to all applicable safety regulations including, but not limited to, Targa's processes and procedures, Site Specific Rules, State and Federal regulations. - Ability to work in changing climate conditions and a plant environment - Must employ the use of Personal Protective Equipment (PPE) as required by the company's Environmental, Health, and Safety policies - Performs other work related duties as needed - Complete other general maintenance in other departments - Work with schedulers and other crafts in order to complete job assignments - High School Diploma or GED equivalent - Working knowledge of the English language, with the ability to speak, read and write to convey information - Ability to think critically and logically to identify the strengths and weaknesses of alternative solutions, conclusions or approaches to problems - Willingness to learn and accept constructive feedback - Basic pipe, valve and fitting knowledge - Possess and maintain a valid driver's license - Must work with a minimum of supervision and be able to manage time when given multiple tasks. - Ability to work overtime, weekends, holidays, and be able to respond to call-outs as need to fulfill business objectives. - Plant pipe, valve, vessels and other equipment maintenance experience - 2 to 3 year' in gas processing, petrochemical, liquid fractionation or refining facility other equipment maintenance experience - Proficient in the use of all Microsoft Office software modules, including Word, Excel, - Previous experience with a CMMS (Computerized maintenance management system) experience (SAP, Maximo etc.) - Experience with work permit process, conduct "What IF" Scenarios, Job Safety Analysis or Job Task Analysis EQUAL EMPLOYMENT OPPORTUNITY: - Ability to lift, push, and pull at least a minimum of 50lbs. - Ability to work in changing climate conditions. - Able to work in close quarters: i.e., work while kneeling, squatting, sitting, climbing, and standing. Targa Resources is an equal opportunity workplace. All employment decisions are made without regard to sex, race, color, religion, national origin, citizenship, age, disability, marital or veteran status, sexual orientation, gender identity or expression, or any other legally protected categories. This includes providing reasonable accommodation if requested for disabilities or religious beliefs and practices.
Falcon High School students in Jordan Tunney’s Street Law class got to put on their detective hats and investigate a fictional cold case. It was a lesson in more than “just the facts.” For the unit on Criminal Justice, the students worked in teams to determine how evidence and testimony could exonerate a wrongfully-accused individual and lead them to the culprit. Communication and teamwork were essential as the investigators cracked the case and put the real "killer" behind bars. “Students were tasked with being critical of physical evidence, written testimony, and supporting facts that in the simulation led to the wrongful conviction of one and the true criminal to remain free,” Tunney said. Students were divided into two teams to share similar resources; one group had arrest records, crime scene photos, fingerprints, autopsy report while the other was provided with Person of Interest information of potential suspects. They had to write and communicate what they found since they could not hand evidence across from one group to the other. “Students had to not just think ‘this guy sounds guilty’ or ‘this alibi is air-tight’ but had to consider ‘why might this person lie’ or ‘does this statement have any support with evidence?’” Tunney said. “Reasoning and abstract thought can be pivotal in a criminal or civil litigation, but I connected their thought process to other academic pursuits, such as weighing textual evidence or primary vs. secondary source support in Social Studies and the weight of evidence in the Scientific Method.”
गाजीपुर न्यूज़ टीम, गाजीपुर गंगा में बढ़ाव जारी है। कई घाटों पर पानी चढ़ने लगा है। तटवर्ती इलाकों के लोग बढ़ाव की तेज रफ्तार से दहशत में हैं। सोमवार की सुबह पांच बजे जल स्तर ५८.१३ मीटर रिकार्ड हुआ जबकि इसके १२ घंटे पहले जल स्तर ५७.५ मीटर नापा गया था। सिंचाई विभाग के एक्सईएन आरके शर्मा ने बताया कि सुबह पांच बजे के बाद भी बढ़ाव जारी रहा। शाम दो बजे तक करीब आधा मीटर जलस्तर और ऊपर आ चुका है लेकिन इसके बाद से बढ़ने की रफ्तार कम हुई है। गंगा खतरे के निशान ६३.१० मीटर से करीब साढ़े चार मीटर नीचे बह रही हैं। जलवृद्धि का कारण मध्यप्रदेश के केन तथा बेतवा नदी का बढ़ाव है। एक्सईएन ने हरियाणा के हथनी कुंड बैराज से छोड़े गए पानी से गंगा में खतरे की गुंजाइश से इन्कार किया। कहे कि उस बैराज का पानी उधर ही रह जाएगा। उधर प्रशासन गंगा में बाढ़ को देखते हुए अलर्ट है। बावजूद तटवर्ती हिस्सों के लोग कटान तथा खेत में जलभराव को लेकर चिंतित हैं।
हम विशेष हैं डेल्टामैथ्रिन समाधान निर्माताओं और आपूर्तिकर्ताओं / कारखाने चीन से। कम कीमत / सस्ते के रूप में उच्च गुणवत्ता के साथ थोक डेल्टामैथ्रिन समाधान, चीन से अग्रणी ब्रांडों में से एक डेल्टामैथ्रिन समाधान में से एक, हेबी केक्सिंग फ़ार्मास्युटिकल को., लैड.। थोक चीन से डेल्टामैथ्रिन समाधान , लेकिन कम कीमत के अग्रणी निर्माताओं के रूप में सस्ते डेल्टामैथ्रिन समाधान खोजने की आवश्यकता है। बस डेल्टामैथ्रिन समाधान पर उच्च गुणवत्ता वाले ब्रांडों पा कारखाना उत्पादन, आप आप क्या चाहते हैं, बचत शुरू करते हैं और हमारे डेल्टामैथ्रिन समाधान का पता लगाने के बारे में भी राय, आप में सबसे तेजी से उत्तर हम करूँगा कर सकते हैं।
QT5-15 Automatic Brick Making Machine LONTTO QT5-15 concrete block making machine is the special equipment for the producing building blocks. The machine can widely use fly ash, slag, coal gangue or other industrial waste and river sand, gravel, cement and other materials to produce hollow blocks, color paver blocks, solid blocks. - Automatic with Siemens PLC control system - 5 PCS 8′ blocks/cycle with 15 seconds forming time. - High efficiency and strong steel frame. The machine consists of five parts: pallet feeder, block moulding machine, block conveyor, hydraulic station, and the electric control cabinet etc. - This machine is a comprehensive technical equipment for mechanical, hydraulic and computer automatic control. It is characterized by high efficiency, reasonable design, compact structure, simple operation and convenient maintenance. The products are formed mainly by hydraulic pressure, mechanical assisted, also with vibration pressurize. - The produced block products can withstand compressive strength of up to 15 MPa (megapascals), high compactness, with good anti-freeze and anti-seepage performance, excellent sound insulation, heat insulation and thermal insulation properties, accurate dimensions, good product consistency and low scrap rate. - The design and manufacture of QT5-15 Block Making Machine meets the requirements of the professional recommendation—JC/T920-2003 Building materials industrial block making machine - The block making machine has high degree of automation, intelligent electronic control, automatic process using advanced foreign PLC (programmable controller) intelligent control, equipped with product process data input, storage, touch screen, ideal and flexible man-machine dialogue interface. - The automatic control system contains advanced safety logic to control the interlock of the action and has a fault diagnosis system. - The reliability of the QT5-15 concrete block making machine is good. Its hydraulic system adopts well-designed and well-made hydraulic components with reasonable hydraulic system design. - The machine adopts an independent integrated hydraulic pump station to avoid the influence of machine vibration and dust on the hydraulic system, to ensure the working reliability of the hydraulic system. - This automatic brick making machine has the good adaptability to the raw materials, it using the advanced step by step vibration molding technology, can use various waste ash slag according to local conditions, reduce the dosage of cement reasonably, produce different kinds of bearing or non-bearing block products with high quality. - 6) This machine has the strong adaptability, it can adjust the products production quickly by changing the block moulds simply, to cater to the needs of the market to the greatest extent, make the machine has the maximum effectiveness. Tech Data of QT5-15 Block Machine: \|Name of the parameter\|\|Data\| \|Max. dimension of the main machine\|\|5120(L)×1950(W)×2810mm(H)\| \|Hydraulic system rated pressure\|\|15-20Mpa\| \|Main vibration type\|\|Platform vibration\| \|Vibration frequency\|\|4500-5100 times/min\| \|Height of bricks\|\|50-200mm\| \|Forming cycle\|\|15-25s, when adding pigment—20-25s\| Production capacity per hour \|Hollow block (390×190×190mm) 950pcs/hr.\| \|Standard brick (240×115×53mm) 6000pcs/hr.\| \|Porous block (240×115×90mm) 2880pcs/hr.\| \|Feeding hopper capacity\|\|Storage hopper effective volume 0.45m3\| \|Feeding car effective volume 0.15m3\| Per day(10 Hours)
Cold Lakeside Morning by Daniel Yuezhou Li Honorable - Natural Category School: University Transition Program Teacher: Ludmila Shepelev The awe-inspiring scene of steam rising off a serene lake early in the morning is a beautiful sight, one that owes its appearance to a physical phenomenon that happens in the fall known as steam fog or evaporation fog. The high heat capacity of water causes the lake to lose less heat overnight than the land around it. On clear nights, the cooler land chills the air around it. In the morning, as water evaporates from the surface of the lake, it condensates upon contact with the cool air above, forming tiny droplets of water. These tiny droplets of water constitute the fog, which appears similar to steam rising off the water, hence the name “steam fog”. This phenomenon occurs during the autumn because the lake is relatively warmer from retaining more summer heat than the land and air around it. In the spring, the lake is colder from the winter chill, and since water is slow to warm just like it is slow to cool, the lake ends up being colder than the air above it, which causes a different type of fog––advection fog.
The School of Operations Research and Information Engineering at Cornell is consistently placed among a handful of leading Operations Research programs worldwide. Our program fosters an intense collaborative research community in keeping with our history of academic excellence. Cornell’s program in Operations Research and Information Engineering is a rigorous program with approximately 225 undergraduates, 90 Master of Engineering students, and 40 Ph.D. students. Students have received a variety of awards and recognition including for example, recognition from INFORMS and SIAM and fellowships from the Hertz Foundation, National Science Foundation, National Institutes of Health, National Defense Sciences and Engineering, Department of the Navy, Department of Energy, and IBM. ORIE focuses on fundamental principles and methods but also uses contextual learning and design experiences to integrate the science with engineering. Our approach to engineering education, both graduate and undergraduate, emphasizes broad mastery of core areas of the discipline: - methods of optimization - applied probability modeling and statistical analysis - manufacturing systems design and operation - systems analysis and methodology. We invite you to join us!
Southern cultivator. (Augusta, Ga.) 1843-188? Place of Publication: - Augusta, Richmond county Dates of publication: - Began in 1843. - Agriculture--Southern States--Newspapers. - Augusta (Richmond County, Ga.)--Newspapers. - Richmond County (Ga.)--Newspapers. - A journal, devoted to the interests of Southern agriculture; designed to improve the mind, and elevate the character of the tillers of the soil, and to introduce a more enlightened system of culture. - Description based on: Vol. 22, no. 4 (April 1864); title from caption. Southern cultivator. April 1, 1867 J.W. and W.S. Jones published the first issue of the Southern Cultivator on March 1, 1843 in Augusta, Georgia. The paper was a semi-monthly journal that featured essays and educational materials related to southern agriculture. The first year included articles on subjects such as the preservation of peach trees, preparation for winter, and preventing whooping cough. After the Civil War, the Cultivator moved to Athens, Georgia with Wm. and W. L. Jones as the editors and publishers. The paper’s publishing frequency transitioned to monthly and it called itself an “Agricultural and Literary Monthly Publication.” The paper remained in Athens until 1881 when it began printing out of the offices of the Atlanta Constitution. The paper gradually absorbed other farm journals and became the Southern Cultivator and Dixie Farmer after merging with the Dixie Farmer in 1882. The Cultivator returned to semi-monthly publication in 1884 under the ownership of J.P. Harrison and Company. In the late 1880s, the journal was reorganized under the Cultivator Publishing Company, which retained ownership of the paper into the twentieth century.
LowRiderGhost write: I'm coming up with Fram #CH6000 or #CH6001, Emgo #1029800 or K&N #KN133. Just put those numbers in the search engines and the URL's (where to buy) will come up! :) Never owned a GS750 - did ride one once though (long time ago - friend had one). Did own the old predecessor to that model at one time: 1976 Suzuki GT750A LeMans (Water-Cooled Triple, 2-Stroke). Anyone remember that one?! Oh I do!!!! Isn't that the one that made the mememeemmememe sound when you were running it???
""" Create a function that returns True when num1 is equal to num2; otherwise return False. Examples is_same_num(4, 8) ➞ False is_same_num(2, 2) ➞ True is_same_num(2, "2") ➞ False Notes Don't forget to return the result. """ def is_same_num(num1, num2): return num1 == num2
Newswise — Pancreatic cancer’s low survival rate gives researchers from The University of Kansas Cancer Center even more reason to find a way to prevent and treat the hard-to-detect cancer. Drs. Snigdha and Sushanta Banerjee, Ph.D., a husband and wife research team at the Kansas City VA Medical Center, are working towards cutting off the growth of pancreatic tumors before they can metastasize throughout the body. Their main target is angiogenesis—or creating new blood vessels from existing ones. Pancreatic cancer and other cancers can only thrive, grow and spread if they have nutrients from blood, just like other tissues in our bodies. Cancer cells and tumors at first rely on nearby blood vessels to get what they need to survive, but, as tumors grow, they need to form new vessels. These vessels differ from those in regular tissue, Sushanta explained, which is part of the reason cancer can be so difficult to treat. “Tumor blood vessels are different than regular blood vessels,” said Sushanta. “Tumor vessels are sluggish and leaky, so when we try and treat cancer with drugs they can’t easily reach the tumor because the vessels aren’t strong.” In previous research, the Banerjees discovered that a particular protein, CCN1, is overexpressed in pancreatic cancer, which leads to tumor formation. Knowing that this protein could be a key target in treating pancreatic cancer, they sought to understand exactly how it works. In a recent paper published in Scientific Reports (Nature publishing group), they explain how CCN1 signals tumor angiogenesis in pancreatic cancer. CCN1 promotes new blood vessel growth in both normal and cancer tissues. But CCN1 does something extra when it’s secreted by pancreatic tumor cells as opposed to regular cells. It both promotes angiogenesis within the tumor and increased the migration of endothelial cells, which form the inner lining of blood vessels. This migration process is key in the formation of the tumor vessels, according to the National Cancer Institute. “The tumor cell secretes CCN1 into itself, which is a signal to start angiogenesis,” said Snigdha. “So it seems that if you can target CCN1 with a drug, then the tumor will shrink and stop growing.” There is another piece necessary for the pancreatic cancer cell to start forming its own blood vessels - through their research, the Banerjees found that CCN1 is a crucial regulator of SHh, or the “sonic hedgehog” gene. They found that SHh activated by CCN1 also promotes blood vessel formation in the pancreatic cancer cells.“Both of these components seem to be critical for angiogenesis,” said Sushanta. Understanding this process can lead to better targeted therapies for pancreatic cancer. When the Banerjees knocked down the CCN1 protein using shRNA, very few vessels and capillaries formed under mouse skin. This finding suggests that finding or creating a drug that silences CCN1 could slow down or even stop pancreatic cancer tumors from growing. Pancreatic cancer is one of the most aggressive cancers. Nearly 40,000 people are estimated to die from pancreatic cancer in 2014 and there will be around 46,000 new cases diagnosed, according to the National Cancer Institute. Only 6.7 percent of those diagnosed with pancreatic cancer will go on to live at least five years. “The next step would be to find an existing drug that can target the CCN1 protein, or create one,” said Snigdha. Funding sources: Merit Review Award grant from the Department of Veterans AffairsCo-authors: Gargi Maity (Cancer Research Unit, Kansas City VA Medical Center and Division of Hematology and Oncology, University of Kansas Medical Center), Smita Mehta (Cancer Research Unit, Kansas City VA Medical Center), Inamul Haque, (Cancer Research Unit, Kansas City VA Medical Center and Division of Hematology and Oncology, University of Kansas Medical Center), Kakali Dhar (Cancer Research Unit, Kansas City VA Medical Center) and Sandipto Sarkar (Cancer Research Unit, Kansas City VA Medical Center and Department of Pathology, University of Kansas Medical Center)
Not satisfied with students' progress on district- and state-mandated tests -- and after careful deliberation by administration and staff -- the Edwards Middle School implemented the Massachusetts Expanded Learning Time (ELT) Initiative in the 2006/07 school year. ELT has since become an integral part of the school day, where students receive an additional 60 minutes of support instruction in some core academic classes like English and math, and 90 minutes of electives in arts, sports and music, and other enrichment activities. In order to maximize the benefits of ELT for students, I looked for ways to fine tune my approach to teaching individualized learning in my English language arts classroom. One of the instructional models that informs my approach to teaching individualized learning is the Readers and Writers Workshop. This approach proved very helpful in optimizing ELT. Readers and Writers Workshop: An Instructional Model The workshop model for English instruction combined with an extended 60 minutes of ELT support for my struggling students provides an excellent springboard to plan and implement individualized instruction in my class. Readers and Writers Workshop is an instructional model that focuses on students as learners, as well as readers and writers in practice. As readers and writers, students are mentored, working in a supportive and collaborative environment with their mentor on touchstone texts. There is an inherent reading-writing connection with this instructional delivery system that includes the following phases: 1. Mini-lesson (10-15 minutes) This phase involves a teacher modeling a reading or writing strategy for the students to practice. It could also involve a "do now" to tap into students' prior knowledge. Students might build a schema around a specific strategy that the teacher had modeled previously -- or do an activity to see what they retained of the day's lesson. (See a a sample lesson plan (PDF).) 2. Guided or independent student practice (40-45 minutes) This is a student work time allocated for practicing the modeled strategy. During this phase the teacher circulates the room conferring with individuals and small groups. He takes notes, makes informal assessments, and provides one-on-one support to struggling learners. 3. Reflection (5-10 minutes) This phase allows the whole class to regroup and review the lesson objectives, share learning, and reflect on what worked or did not work. The workshop model provides for both independent and collaborative learning, and thus fosters student ownership of the learning process. This approach strongly emphasizes a student-centered approach to learning. Reaching All Learners in the ELA Classroom As a middle school ELA teacher, I continue to collaborate with my peers in the building and across the school district. I participate in planning and designing instruction, inquiry-based studies, and collaborative coaching and learning. These activities have provided me with a repertoire of research-based best practices to engage the readers and writers in my ELA classroom. I teach four core ELA classes Monday through Friday, and one support ELA class Monday through Thursday. Two of my core classes are inclusion, with a third of the students in each on individual education plans (IEP). I co-teach with a specialist who supports the students on IEP. The specialist and I also plan instruction to ensure that all students are able to effectively access the curriculum. We provide frequent check-ins and modify instruction to meet everyone's needs. Our instruction is focused on building stamina in reading and writing to produce critical thinkers and life-long learners. We use the following strategies: 1. Encourage independent reading From the first day of school, we encourage students to choose the books they read. We model how to choose and review a book for reading. We also encourage students to choose books at their independent reading level rather than at their frustration or difficult level. Students read for 30 minutes daily and complete an entry on the reading. (See sample reading questions (PDF).) Students are not only expanding their knowledge as good readers, they are also building reading stamina. 2. Design product-driven reading and writing instruction Plan units that are product-driven. (See a sample lesson plan template (PDF).) Have a key or an essential question that instruction seeks to address in the unit. It should become the epicenter of instruction, thus allowing for mastery. Students become stakeholders when they know the instructional objectives and learning outcome. 3. Pre-reading and pre-writing strategies Infuse pre-reading and pre-writing strategies to build schema. "What I know, what I want to know, and what I learned" (KWL), quick-writes, and vocabulary activities before reading and writing are very useful for tapping into students' prior knowledge and making connections in learning. Quick-writes also provide excellent seed ideas for writing. Expand students' word choice by previewing text vocabulary before reading and providing opportunities for students to find at least three synonyms for unfamiliar words. 4. Making meaning Provide instruction in basic reading strategies using reciprocal teaching practice that includes predicting, visualizing, questioning, clarifying, and summarizing. As students master these strategies, have them read in small groups of three or four, applying the strategies to their readings. Students should be encouraged to rotate roles. As they interact with the text, they are making meaning and comprehending the text. 5. Text annotation Teach students to mark or highlight text for main ideas and also for answers to specific questions. Text annotation is an excellent method to make meaning and provide evidence to support answers. 6. Ask text-based evidence questions Challenge students to provide specific evidence to support their answers. Use t-chart graphic organizers to have them identify specific lines from a text and explain their thoughts about the lines. 7. Immerse students in the genre Provide adequate opportunity -- one to two weeks -- for students to examine text features and structures, and to read and learn from mentor texts and literature before writing. 8. Provide options for writing As students examine mentor texts in their reading, provide a variety of writing samples for them to learn from. Teach a variety of genres. Encourage learning and practicing the craft of authors through modeling, conferring, and collaboration. 9. Analyze and interpret Teach strategies that emphasize analysis and interpretation -- examine author styles and use of language through literal and figurative analysis to get meaning from text. I apply this model to ELT by working with kids twice a day. In the morning class, it is strictly curriculum-driven; students are using the workshop as a means to their own learning. In the afternoon, I guide them to help remediate the skills they need to improve their comprehension. Have you used this workshop model, and if so, do you have any other techniques for how you've been able to individualize instruction? Please share any questions or experiences in the comments section below.
Beuys lets the medium take centre stage in this work. Made of five pieces of paper, it is titled after the distinctive brown oil paint the artist used, whose name translates as 'Brown cross'. Compared to his more delicate watercolour drawings of the 1950s, Beuys's Braunkreuz works are bold and have a sculptural aspect. The medium was named by the artist himself, whose love of language and word play is demonstrated in the name's composition, where two words compound to make a new word. This echoes the composition of the cross shape, where two elements intersect to form a third.
Have you ever struggled to find TV shows for your toddler that aren’t too overstimulating or too advanced for their age? Trust me, you’re not alone! As a parent or caregiver, it’s important to find age-appropriate and educational shows that can engage and entertain our little ones without overwhelming them. That’s why I’ve compiled a list of some of the best low-stimulating TV shows for toddlers (shows my toddler loves!) From Bluey to Franklin, these shows are sure to keep your kiddo entertained while also providing some valuable lessons! Best Low Stimulating Shows for Toddlers “Bluey” is an Australian animated children’s television series created by Joe Brumm. The show follows the adventures of a lovable Blue Heeler puppy named Bluey and her family, including her father Bandit, mother Chilli, and little sister Bingo. Set in Brisbane, the series explores the joys and challenges of everyday family life, emphasizing play, imagination, and strong family bonds. With its relatable stories, humor, and positive messages, “Bluey” has gained widespread acclaim for its appeal to both children and parents alike. Have you heard of the show Trash Truck? It’s a super cute and fun show for toddlers that’s definitely worth checking out. The show follows the adventures of a young boy named Hank and his best friend, a giant trash truck who loves to play and explore. Together, they go on all sorts of adventures, meeting new friends and learning new things along the way. One of the reasons Trash Truck is such a great show for toddlers is because it’s full of fun and excitement. Kids will love watching Hank and his trash truck friend zoom around town and discover new things together. But the show is more than just fun and games – it also teaches important lessons about friendship, empathy, and problem-solving. As Hank navigates the challenges of growing up, he learns how to be a good friend and how to work through difficult situations. Overall, if you’re looking for a show that’s both entertaining and educational for your little ones, Trash Truck is a great choice. It’s sure to become a favorite in your household in no time! The show features a group of adorable animal friends who love to read books and go on adventures. Each episode is centered around a different storybook, and the characters act out the story as they read it together. One of the reasons Storytime Book is such a great show for toddlers is because it promotes a love of reading and storytelling. Watching the characters act out stories in a fun and engaging way can help kids develop a deeper appreciation for books and reading. But the show also has important lessons about friendship, problem-solving, and empathy. As the animal friends navigate different storybook worlds, they learn how to work together and help each other out. Overall, if you’re looking for a show that’s both entertaining and educational for your little ones, Storytime Book is a great choice. It’s sure to inspire a love of reading and help your child learn important values along the way. Daniel Tiger’s Neighborhood The show is based on the beloved characters from Mr. Rogers’ Neighborhood and follows the adventures of a young tiger named Daniel and his friends. Each episode focuses on a different theme, such as sharing, kindness, or patience. One of the reasons Daniel Tiger’s Neighborhood is such a great show for toddlers is because it’s designed to teach important social and emotional skills. The characters model positive behavior, such as empathy and problem-solving, that kids can learn from and apply in their own lives. Another great thing about the show is the catchy songs that go along with each theme. The songs are easy for kids to sing along with and help reinforce the lessons in a fun and memorable way. Overall, if you’re looking for a show that’s both fun and educational for your little ones, Daniel Tiger’s Neighborhood is a great choice. It’s sure to entertain and inspire your child while teaching important life skills along the way. Chip and Potato “Chip and Potato” is a delightful animated series tailored for toddlers, offering a low-stimulating and calming experience. The show revolves around the adorable friendship between Chip, a pug, and Potato, a tiny mouse. With its gentle pace, colorful visuals, and positive messages about friendship and problem-solving, it’s a perfect choice for young viewers. “Tumble Leaf” is a captivating and tranquil show designed for toddlers. The stop-motion animated series follows Fig, a blue fox, as he explores a whimsical world filled with intriguing objects. With its soothing narration, imaginative storytelling, and emphasis on curiosity and discovery, “Tumble Leaf” provides a perfect blend of entertainment and education. Sea of Love “Sea of Love” is a heartwarming kids’ TV show that dives into the magical underwater world of friendship, adventure, and marine life. Join our young heroes as they explore the deep sea, solving mysteries, and learning valuable life lessons. With vibrant animation and captivating storytelling, it’s a delightful aquatic journey for young viewers. “Puffin Rock” is an enchanting animated series that transports young viewers to a picturesque island off the coast of Ireland. The show follows Oona, a curious and kind-hearted puffin, as she embarks on delightful adventures with her brother, Baba, and their friends. With its gentle storytelling and stunning visuals, “Puffin Rock” is a captivating and educational treat for children. Charlies Colorform City “Charlie’s Colorform City” is a vibrant and imaginative animated series perfect for preschoolers. Charlie, a lovable character, uses his Colorforms – magical stickers – to bring the world around him to life. With its creative storytelling, interactive elements, and lessons on problem-solving, the show sparks young children’s creativity and curiosity. “Arthur” is a beloved animated series that follows the adventures of an 8-year-old aardvark named Arthur Read. Set in the fictional town of Elwood City, the show portrays Arthur’s everyday life, school experiences, and interactions with family and friends. With its engaging stories and positive messages, “Arthur” has been praised for its educational value and entertainment for children of all ages. Llama Llama” is a heartwarming animated series based on the popular children’s book series by Anna Dewdney. The show centers around Llama Llama, a curious and lovable young llama, as he navigates various childhood experiences with the help of his family and friends. With its relatable themes and gentle life lessons, “Llama Llama” is a delightful and educational show for preschoolers. Ben and Holly’s Little Kingdom “Ben and Holly’s Little Kingdom” is a delightful animated series that follows the adventures of Ben Elf, a young elf, and Holly Thistle, a fairy princess. Set in a magical world filled with enchanting creatures, the show showcases their playful escapades, problem-solving skills, and the importance of friendship and cooperation. With its charming characters and imaginative storytelling, “Ben and Holly’s Little Kingdom” captivates young audiences and encourages their creativity. Take your parenting journey to the next level with our comprehensive ebook on Connected Parenting. Download this ebook now and embark on a transformative parenting experience that will strengthen your bond with your child and bring joy and fulfillment to your family life. “Twirlywoos” is a popular British-Canadian children’s television series created by Anne Wood and Steve Roberts. The show features adorable, bird-like characters called Twirlywoos, who live on a big red boat and explore the human world with curiosity and wonder. Each episode follows their amusing and educational adventures as they interact with everyday objects and people, promoting learning through play and discovery. The show is known for its colorful animation, catchy music, and entertaining humor, making it a hit among preschool audiences. If you’re looking for a great show to watch with your toddler, Care Bears is definitely worth considering! Here’s why: First of all, the show is specifically designed with young children in mind. It’s full of bright colors, catchy tunes, and easy-to-follow storylines that are perfect for little ones. But it’s not just fun – Care Bears also has a really positive message that focuses on kindness and empathy. These are important values that we want our kids to learn from an early age, and the show does a great job of promoting them in a way that’s easy for toddlers to understand. Another great thing about Care Bears is that it’s all about emotions and social skills. By watching the characters work through their own emotional struggles, toddlers can learn a lot about how to recognize and manage their own feelings. And the emphasis on friendship and empathy can help them develop better relationships with others, too. “Franklin” is an excellent low stimulating show for toddlers due to its gentle pacing and relatable themes. The animated series follows Franklin the turtle and his friends as they navigate everyday experiences, promoting emotional intelligence, problem-solving, and friendship. Its calm visuals and engaging storytelling offer a soothing and educational viewing experience for young children. “Little Bear” is another fantastic low stimulating show for toddlers. This gentle animated series revolves around the adventures of Little Bear and his woodland friends, fostering imagination, kindness, and creativity. With its slow-paced storytelling, warm visuals, and emphasis on friendship and family, “Little Bear” provides a comforting and enriching viewing experience for young audiences. Clifford the Big Red Dog “Clifford the Big Red Dog” is a wonderful low stimulating show for toddlers. This animated series features the lovable giant dog, Clifford, and his owner, Emily Elizabeth, as they embark on heartwarming adventures. The show’s positive messages, simple animations, and slower pace make it ideal for young viewers, offering valuable lessons in friendship, kindness, and empathy. Guess How Much I Love You “Guess How Much I Love You” is a beautiful low stimulating show for toddlers. Based on the classic children’s book, the animated series follows the endearing adventures of Little Nutbrown Hare and his father, Big Nutbrown Hare. The show’s calming visuals, sweet storytelling, and themes of love and connection create a soothing and heartwarming experience for young viewers. How Important Is It To Show Low Stimulating Shows to Toddlers Showing low stimulating shows to toddlers is highly important for their overall well-being and development. Toddlers’ brains are still developing, and exposure to excessive stimuli can overwhelm their senses and hinder cognitive growth. Low stimulating shows, with gentle visuals and calming content, promote healthy attention spans, emotional regulation, and creativity. These programs encourage imaginative play, critical thinking, and language development without overloading young minds. Moreover, limiting high-stimulation content reduces the risk of adverse effects on sleep patterns and behavior. By offering appropriate, age-specific shows, parents can create a balanced media experience that fosters learning, nurtures curiosity, and supports toddlers’ healthy growth and development. What Makes a Show Overly Stimulating for a Toddler? Several factors can make a show overly stimulating for a toddler: - Fast-Paced Visuals: Rapidly changing scenes, flashy animations, and bright colors can overwhelm a toddler’s developing visual system, making it hard for them to focus or process information. - Loud and Intense Sounds: High volume levels, loud music, and constant sound effects can be distressing to toddlers, leading to sensory overload and agitation. - Chaotic and Busy Scenes: Shows with numerous characters and complex storylines can be difficult for toddlers to follow, causing confusion and frustration. - Excessive Action and Violence: Programs with intense action or violence can be too emotionally intense for toddlers, making them anxious or scared. - Repetitive and Overused Content: Endless repetition of songs, phrases, or actions can become monotonous, reducing a toddler’s interest and engagement. - Lack of Predictability: Toddlers thrive on predictability and routine. Shows with unpredictable or jarring content can disrupt their sense of security. - Excessive Screen Time: Prolonged exposure to screens, even with low-stimulation content, can lead to negative effects on attention spans and overall development. What kid shows are not overstimulating? “Bluey,” “Twirlywoos,” “Puffin Rock,” and “Llama Llama” are excellent examples of kid shows that are not overstimulating. These series strike a balance between gentle storytelling, calming visuals, and age-appropriate content, offering young viewers an engaging and educational experience without overwhelming them with excessive stimulation. What shows are over stimulating for toddlers? Shows that are overstimulating for toddlers often have fast-paced visuals, loud and constant sounds, rapid scene changes, and intense action sequences. Some examples may include highly animated action shows or programs with rapid editing and bright, flashing colors that could overwhelm young viewers’ senses and attention spans. What is the best show for toddlers to fall asleep? “The Goodnight Show” by Sesame Street is an ideal choice for toddlers to fall asleep. This calming and soothing program features classic Sesame Street characters engaging in bedtime routines, gentle storytelling, and lullabies. Its soft visuals and relaxing content help create a peaceful environment, making it easier for little ones to drift off to sleep. Is CoComelon overstimulating? CoComelon is well-known for its vibrant and colorful animation, which can lead to overstimulation in toddlers. The constant visual stimuli, coupled with the repetitive songs and fast-paced scenes, may overwhelm young viewers and impact their attention spans. Parents should consider monitoring screen time and opting for more calming shows to create a balanced viewing experience for their children. How do you fix overstimulation in toddlers? To address overstimulation in toddlers, create a calming environment with minimal distractions. Offer predictable routines and limit excessive screen time, loud noises, or chaotic activities. Encourage soothing activities like reading, gentle play, or spending time in nature. Pay attention to the child’s cues and provide a safe space for relaxation and emotional regulation. Is Bluey Low stimulating? Yes, “Bluey” is considered low stimulating for toddlers. The show features gentle storytelling, colorful but not overwhelming animation, and relatable family scenarios. It promotes imaginative play and emotional learning without excessive stimuli, making it an excellent choice for young viewers’ development and engagement. What are signs of sensory overload in toddlers? Signs of sensory overload in toddlers include covering their ears, avoiding eye contact, becoming irritable or restless, displaying repetitive behaviors, having meltdowns or tantrums, or seeking isolation. They may also become overly clingy or resistant to touch. Each child’s response may vary, so understanding their unique cues is essential for addressing sensory overload effectively.
1. Fill Leo with Goodies Find the trumpet-shaped end, or cross-cut holes on the side and/or bottom of the toy. Push in the treats. 2. Connect Leo Toys Fold the trumpet-shaped end of one toy and pop it into the cross-cut hole of another. Each toy has two cross-cut holes so you can make all sorts of fun configurations for your dog. 3. Multiple Leo Toys When you attach several toys together, their hollow spaces become interconnected.That means treats can transfer from one toy to another - potentially limitless entertainment.
Links & Resources We will continue to share a number of links with you via our Facebook page which we hope will provide guidance and support for families. We understand it can be a little difficult to find a specific post in our timeline so we have listed below all the links we have included to date in one handy list. Multiplication and Division Games to play at home You do not need to print the instructions and you can write the equations and answers into your home learning books. Games to play at home: http://mathperspectives.com/wp-content/uploads/2020/04/Grab-a-Handful-At-Home-.pdf (Instructions don't need printing) Addition and Subtraction Activities Games to play at home: The resources that you will need for these games are: paper, a pencil/pen, a cup or bag, small items to count (such as counters, marbles, Lego bricks or dried pasta). You do not need to print the instructions and can write the equations and answers into your home learning books. Time Resources and Activities: You can play with setting time on the clock and explore how the clock works in relation to time including seconds, minutes and hours. - When cooking dinner (whether it be you or your grown ups), can you write down the timings? This includes how long it takes to prepare the food as well as how long it takes to bake a cake. - Can you time yourself doing your daily exercise? How long did it take? What time did you start? What time did you finish? - Can you challenge someone at home to the time game that Stephen Mulhern loves to play on his Saturday evening TV programme 'In for a Penny'? You decide on a set amount of seconds as the target (e.g. 10 seconds), the judge has a stopwatch and tells you when to begin. You need to tell the judge to stop the stopwatch when you think it has been that exact number of seconds. Keep taking it in turns and changing the target. Times Tables Songs: Many of you will be using Times Tables Rockstars to practise your times tables but you can also use songs. Here are some great ones that you might want to learn: The BBC Bitesize website is fantastic for reviewing topics and going over key skills. Here are some areas you might like to recap: - Addition and Subtraction: https://www.bbc.co.uk/bitesize/topics/zy2mn39 - Multiplication and Division: https://www.bbc.co.uk/bitesize/topics/z36tyrd - Fractions: https://www.bbc.co.uk/bitesize/topics/zhdwxnb Topmarks Website - Games and Activities: Topmarks is a great website for online learning games. We have selected some useful ones to support with various areas of learning. - Ordering numbers: - Multiplication, Division, Halving and Doubling: - Four Operations: Carol Vorderman - The Maths Factor: This website is free to sign up to. We would recommend your grown ups creating a login; you can then explore all of the online activities that they have available. - Printable maths board games (Mathopoly looks particularly fun!) https://www.twinkl.co.uk/resources/extra-subjects-parents/parents-activites-games/parents-number-maths-games - Printable maths board games - http://www.mathematicshed.com/uploads/1/2/5/7/12572836/21funmathgames.pd

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