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गया. आठ ग्राम वाली गिन्नी 26,400 रुपये प्रति इकाई के पहले के स्तर पर रही. हालांकि अंतर्राष्ट्रीय बाजार में सोना मामूली बढ़कर 1295.50 डॉलर प्रति औंस पर रहा जबकि चांदी बढ़त के साथ 15.13 डॉलर प्रति औंस पर रही. मनरेगा से तालाबों को मिला नया जीवन उधर बताया गया कि मांझा मीरापुर द्वाबा के अभिलेख हाईकोर्ट के आदेश से सील किए गए हैं। इसी के चलते फिलहाल निरीक्षण कार्य स्थगित कर दिया गया है। चैत्र मास की शुक्ल पक्ष में पड़ने वाली एकादशी को कामदा एकादशी कहा जाता है। आज 7 अप्रैल के दिन यह शुभ घड़ी है। परिवारों को मुआवजा, नौकरी की मांग सवाल : कोरोना के बाद लगी पूर्णबंदी का फिल्मजगत पर काफी असर हुआ है। आप पर क्या असर हो रहा है? ससुर को पता ही नहीं, अब दामाद नहीं रहे ताज के रेड जोन (स्मारक परिसर) में सीआइएसएफ और यलो जोन (500 मीटर की परिधि) में पुलिस सुरक्षा व्यवस्था संभालती है। ताज के 500 मीटर के दायरे में ड्रोन उड़ाना प्रतिबंधित है। इसके बावजूद यहां सैलानी जानकारी के अभाव में ड्रोन उड़ा देते हैं। दुष्कर्म के दोषी को दस वर्ष के कारावास की सजा हसनपुर। गुरुवार रात आई आंधी और बारिश से जगहजगह विद्युत पोल टूटकर</s>
# Задание 2 # Опишите классы графического объекта, прямоугольника и объекта, который может обрабатывать # нажатия мыши. Опишите класс кнопки. Создайте объект кнопки и обычного прямоугольника. Вызовите # метод нажатия на кнопку. class Rectangle: left_down = [100, 50] right_up = [250, 175] class Click(Rectangle): def __init__(self, x_new, y_new): self.x = x_new self.y = y_new def do_click(self): if self.left_down[0] < self.x < self.right_up[0] and \ self.left_down[1] < self.y < self.right_up[1]: print('You hit the rectangle with click') else: print('You missed the target with a click') while True: print('Where do you want to click?') x = int(input('Enter coordinate x: ')) y = int(input('Enter coordinate y: ')) click = Click(x, y) click.do_click() again = input('Do you want to try again (Yes/No)?') if not again.lower() in ['yes', 'y']: break
Top Fixes To Put Your Thesis On Track People go through struggles with their dissertations at different phases of writing it. From generating the idea to the process of handing it over to the supervisors, it may be a daunting task to many students. Whenever you feel like you are putting up a struggle, be aware that you are not alone. Several hundreds of thousands have walked the same path as you and have made it. The grapples are standard, and your goals are achievable. The essence of a dissertation is to answer a question. - Identify your research question and recap it. Most advisors want to see this first. Make sure your research question is simple but informative. What is its motive, and what are you trying to answer? - What to do if you are stuck at the beginning The best way to start your dissertation is through reading. It will help you in getting your ideas flowing seamlessly. You will have ideas of what got discussed in your topic’s area and the issues that surround it. - What to do if you lack what to say If you find yourself backed in this corner, do thorough research. Look for arguments, patterns, or themes through other people’s work that may spark great discussions. - Let your instincts lead you Studies have shown that 90% of the time, people are always right when they trust their gut. If you feel something catches your attention or you have an interest in it, go with it. As you go through the reading process, make sure you note down things that catch your attention. - Write down all information you find Have a stack of index cards to help you take down short notes while reading. They are easier to handle and move around than notebooks. With this at hand, write everything down because your memory may fail you, as you may painfully try to remember a small detail but fail to find it. - What to do if you hit a dead-end If you are struggling, make it a habit of working every day, weekends included. It will help you stay on track with your work. It is easy to pick up from where you left if it was soon as yesterday. Getting back to a task you have stopped for a week or so will be confusing. - What to do if you are lagging Go to your advisor and discuss this issue to have options. Assess the situation and see if you can compensate for the lost time by adding a few extra hours every day. You can vent for a time extension. - What to do if you feel you have a terrible idea If you put too much time on a project, you will start doubting your work. Your work gets done when it is more right than wrong. Remember that you don’t need to be perfect. The examiners will give you suggestions, in the long run, no matter how brilliant your topic might be. However, to make your thesis paper better, feel free to reach out a professional coursework writing service and find the help you need. - What to do if your idea is not viable You will need to account for your project and develop a different approach. You should know that most academic works go hand in hand with other people’s work. Someone somewhere is always looking for answers to the same questions you are asking. If you find yourself in this situation, reach out and contact the owner.
साउथ एमसीडी के हाउस टैक्स दोगुना किए जाने के खिलाफ कांग्रेस ने आंदोलन की धमकी दी है। कांग्रेस के पूर्व विधायक मुकेश शर्मा ने बुधवार को आरोप लगाया है कि साउथ एमसीडी ने अपने इलाके में हाउस टैक्स दोगुना कर दिया है, इससे जनता में काफी रोष है, अगर साउथ एमसीडी ने इसे वापस नहीं लिया वो इसके खिलाफ सड़कों पर उतरेंगे, सड़क जाम कर देंगे। बुधवार को एक प्रेस कांफ्रेंस कर कांग्रेस के पूर्व विधायक मुकेश शर्मा ने यह जानकारी दी। उन्होंने कहा कि जिन संपत्तियों में किराएदार हैं उनमें सीधा हाउस टैक्स दोगुना करने का आदेश जारी हो गया है। उन्होंने कहा कि साउथ एमसीडी में सैकड़ों अनधिकृत कॉलोनियां और शहरीकृत गांव इससे प्रभावित होंगे। वहां के लोग एमसीडी के इस फैसले से गुस्से में हैं। मुकेश ने कहा कि इन इलाकों में लोगों को साउथ एमसीडी की तरफ से लोगों को बाकायदा नोटिस जारी किया जा रहा है। उन्हें डर दिखा कर वसूली की जा रही है। मुकेश शर्मा ने यह भी आरोप लगाया कि एमसीडी के इस फैसले को दिल्ली सरकार की भी अनुमति है। क्योंकि दिल्ली सरकार का शहरी विकास मंत्रालय सीधे तौर पर एमसीडी के प्रस्ताव को देखता है। कांग्रेस में गुटबाजी चरम पर! प्रदेश कांग्रेस में गुटबाजी चरम पर पहुंच चुकी है। जनहित के मुद्दे पर भी खुलकर गुटबाजी हो रही है। कांग्रेस के पूर्व विधायक ने साउथ एमसीडी द्वारा हाउस टैक्स बढ़ाए जाने के खिलाफ आंदोलन करने की सूचना मीडियाकर्मियों को मंगलवार को दी थी। जैसे ही इसकी सूचना प्रदेश कांग्रेस को लगी उन्होंने भी गुरुवार को इस मुद्दे को लेकर प्रेस कांफ्रेंस की घोषणा की। लेकिन मुकेश शर्मा के आंदोलन के एलान के बाद बुधवार की शाम को प्रदेश कांग्रेस ने अपनी प्रेस कांफ्रेंस रद्द कर दी। सूत्रों का कहना है कि जनहित के मुद्दे पर भी कांग्रेस के लोग साथ चलने को तैयार नहीं है। जबकि अभी कांग्रेस को अपनी जमीं फिर से बेहतर करने के लिए एक साथ मिलकर बीजेपी और आप के खिलाफ सड़कों पर उतरना चाहिए था।
Spiced Parsnip Cupcakes Recipe Dean Edwards, TV chef and ex Masterchef finalist, gets cooking with whole grains and shares a great recipe using vegetables in baking Cost Per Serving Nutrition Per Serving - Calories350 kcal Calories are a measure of the amount of energy in food and drink. Your weight depends on the balance between how much energy you consume and how much energy you use up. If you eat or drink more than you use you can gain weight. If you don’t eat enough you can lose it. Your body wouldn’t function without fat. Fat is an essential part of a healthy balanced diet. It provides fat soluble vitamins and essential fatty acids. But as fat is a rich source of energy (calories), it can easily contribute to weight gain. On average as a nation it seems we’re consuming too much saturated fat. Eating too much can increase your cholesterol, which is a risk factor for heart disease. Replacing saturated fats with unsaturated fats can help maintain healthy cholesterol levels, and reduce the risk of heart disease. Starchy foods like bread, breakfast cereals or potatoes are a good source of carbohydrate and should make up just over a third of the food you eat. When eaten, carbohydrates are broken down into glucose, which is used to fuel cells in your body like brain and muscle cells. Some people think starchy carbohydrates are fattening, but gram for gram it contains less than half the calories of fat. Choose whole grain or high fibre varieties where you can as they often contain more nutrients. On average in the UK we eat too much sugar. Foods and drinks high in sugars are not needed in the diet. So if you have them, make sure they're infrequent and in small amounts, or you risk tooth decay or obesity. Fibre is classed as a carbohydrate and you should aim to eat 30g fibre each day. Eating plenty of fibre is good for your digestive health and is associated with a lower risk of heart disease, stroke, type 2 diabetes and some cancers. All cells and tissues contain protein, so it’s essential for growth, repair and good health. Protein from animal sources such as meat, fish, eggs and dairy products contain all the essential amino acids (the building blocks of protein) needed by the body. If you're vegetarian or vegan, you can get the protein you need through eating a variety of different plant sources such as pulses, nuts and cereals. A small amount of salt is needed in your diet but too much can raise your blood pressure, which increases risk of health problems such as heart disease and stroke. Adults shouldn’t eat more than about 1 teaspoon (6g) per day – and that includes salt already in the foods you eat, not just the salt you add, so check nutrition labels on food packs. Thanks for rating. Now leave a tip or review - Preheat the oven to 180°C, 160°C fan or gas mark 4. Line a 12-hole muffin tin with paper cake cases. - Whisk the butter and sugar together until pale and fluffy, then beat in the eggs, one at a time. - Tip in the flour, mixed spice and baking powder and mix them in. Stir in the milk and then the grated parsnip. - Spoon the mixture into the cake cases until about 2/3 full and bake for 20-30 minutes, or until golden and cooked through. Allow to cool slightly in the tin, then take them out and cool completely on a wire rack. - Blend the cream cheese with icing sugar, to taste. Put the mixture into a piping bag fitted with a small star nozzle and pipe it on top of the cakes (or spread the mixture on the top of the cakes with a palette knife). - Garnish each cupcake with a little fresh lemon thyme or mint, then serve. - Increase the number of muffins you make to 15 or 16 to improve nutrition - To reduce fat and saturated fat content use reduced fat cream cheese
The world’s first application of subsea LiDAR data used to 3D Print an accurate 1:1 physical model of a damaged well part has been announced by Fugro and 3D at Depth, a global provider of advanced subsea LiDAR systems and solutions. The ability to use accurate spatial data in subsea part fabrication with 3D printing, introduces a wide range of possibilities to reduce costs across intervention planning and Life of Field programs. The subsea part fabrication was part of a larger project conducted in early 2016, using 3D at Depth’s subsea LiDAR SL 2 technology and point cloud software. Project Has Cost Effective Implications Across Life of Field Programs and Intervention Planning 3D at Depth was contracted by Fugro to perform subsea laser scanning services on a well abandonment project in Oceania, Australia. The Plugged and Abandoned (P&A) wells located in a water depth of circa 110 meters, were drilled decades earlier and suspended at the time of drilling. Access to accurate data of the manufacture and specifications of these wellheads was limited due to their age. In order to assess feasible options for abandonment, detailed measurements needed to be acquired to achieve final abandoned status. The survey used Fugro’s multi-role intervention vessel, the “Rem Etive” fitted with two work class remotely operated vehicles (ROVs). One of the two FCV Work Class ROVs, of 3000m depth rating, was fitted with an SL2 Subsea LiDAR laser, manufactured and operated by 3D at Depth. The laser was mounted on the crash bar of the Fugro FCV3000 WROV sending near real-time data to the operator on the vessel via a fibre optic multiplexor. Subsea LiDAR Data Collection Approximately 44 million data points were collected at the well in 13.5 hours. The LiDAR laser data was processed using point cloud processing tools to compute the spatial relationships, measurements and orientations of the seabed structures. The resulting deliverables included a 3D point cloud database, a dimensional report for each well, CAD files and a 360° animation of each well, modelled from the point cloud. In addition to subsea LiDAR data, physical measurements were collected by the Fugro ROV using different sizes of V-gauges and rulers. Cross-referencing of the physical and LiDAR measurements with the original drawings helped identify discrepancies in existing drawing dimensions. 3D Print Process (Additive Manufacturing) To create a 1:1 model for the design of an appropriate ‘hot tap’ connector, a 3D print of the top of the well, with its damaged stub, at full scale was required. As the large size of the well cap structure made the cost prohibitive, a hybrid Computer Numeric Control (CNC) machining process, combined with a 3D print of the damaged part, was proposed by 3D at Depth as a viable alternative solution. The first step was to re-processes the point cloud data from the top of the well and then create 3D CAD models of the separate parts. However, this process proved more challenging than first thought due to the complexity of the shape. For this particular part the auto meshing algorithms which convert point clouds into surfaces did not perform well and as a result the CAD model was developed manually, which is also common when modelling complex shapes from terrestrial laser scans. The part was then 3D printed by means of Fused Deposition Modelling (FDM) technology using Acrylonitrile Butadiene Styrene (ABS) thermoplastic material. One of the other two CNC machined parts was made from Acetal and the well cap from ultra-high-molecular-weight polyethylene (UHMWPE). “While the individual sector scans provide millimeter accuracies, the wide area point cloud can provide a 3D dataset of centimeter accuracy across an entire drill center,” confirms Adam Lowry, MD of 3D at Depth Pty Ltd. “Wide area point clouds, when used for planning, have proven to avoid costly surprises which are otherwise only discovered after the intervention vessel is actually on location. Cost savings can be realised from almost any situation where accurate spatial data would be beneficial to planning intervention operations.” 3D at Depth was the first company to commercialize subsea LiDAR technology for oil and gas offshore hydrocarbon extraction. Today, 3D at Depth Subsea LiDAR data is used across a wide range of applications including subsea metrology and complex metrology, IMR planning, as-built surveys, dimensional control surveys, pipeline damage, pipeline curvature, scour quantification, subsea structure movement, scientific seafloor mapping and investigations, historic preservation, and offshore wind farms.
In 1987, Ullah et al. published a paper about a simple and novel granulation process called moisture-activated dry granulation (MADG) (1). In this granulation process, a small amount of water is used to activate the granule formation (i.e., perform agglomeration) without requiring hot air drying of the granules. After creating the moist agglomerates, this process uses stepwise addition and blending of common pharmaceutical ingredients that absorb and distribute moisture, thus resulting in a uniform, free-flowing, and compactible granulation. In 1990, Chen published a study comparing the MADG process with the conventional granulation processes for sematilide hydrochloride tablets (2). Although the active pharmaceutical ingredient (API) in the formulation was cohesive and fluffy, the granulation made with the MADG process was generally comparable with that made through the wet-granulation and roller-compaction processes. In addition, the authors found that MADG was not only a shorter process, but that the final granulation made with the MADG process showed superior flowability and better tablet-content uniformity. In 1994, Christensen employed the MADG process to successfully make pharmaceutical granulations with micro crystalline cellulose, potato starch, and both of these excipients (3). The knowledge that the pharmaceutical industry has gained during the past several years about excipients used for solid dosage forms, the associated granulation equipment, and the manufacturing processes has fostered the acceptance of the MADG formulation process. The authors previously provided a roadmap for selecting excipients and equipment for the MADG process (4). They also described a step-by-step procedure for MADG-based formulation development.This article evaluates the effects of the formulation and process variables on the MADG process, provides examples of the MADG formulation-development and manufacturing processes, and introduces existing and new pharmaceutical excipients that are well-suited for the MADG process. This article also highlights the advantages and wide applicability of the MADG process in solid dosage form formulation development. Active pharmaceutical ingredients. Acetaminophen USP (Rhodia, Cranbury, NJ) and Compounds A, B, C, D (Bristol-Myers Squibb, BMS, New York) were used. At room temperature, the ingredients' water solubility ranged from slightly soluble to practically insoluble. Their particle size (d90) ranged from <20 μm to <200 μm. Excipients. The authors used lactose monohydrate NF (Sheffield Pharma Ingredients, New York), mannitol USP (Pearlitol 160 C, Roquette America, Keokuk, IA), povidone USP (PVP K-12, International Specialty Products, ISP, Wayne, NJ), hydroxypropyl cellulose NF (HPC EXF, Hercules, Wilmington, DE), copovidone NF (BASF Ludwigshafen, Germany), maltodextrin NF (Maltrin 180, Grain Processing, Muscatine, IA), microcrystalline cellulose NF (Avicel PH200 Low Moisture, FMC BioPolymer, Philadelphia); microcrystalline cellulose NF (Avicel PH102, FMC BioPolymer), silicon dioxide NF (Aeroperl 300, Evonik Degussa, Essen, Germany), crospovidone NF (ISP), and magnesium stearate NF (Mallinckrodt, Hazelwood, MO). Manufacturing equipment. High-shear granulators commonly used in the pharmaceutical industry were selected for the MADG process based on the experimental scale. Diosna P1/6 2 L (DIOSNA Dierks und Söhne, Germany) and Aeromatic-Fielder PMA 150 L (Hampshire, England) were used for 400-g and 30-kg batch sizes, respectively. The water-delivery system used for the granulation process was a digital gear pump (model 75111-30, Cole-Palmer, Vernon Hills, IL) equipped with a pressure nozzle (Düsen-Schlick, Coburg, Germany), or any atomization nozzles that can provide similar hollow-cone or flat-fan spray patterns. A Carver press (Carver, Wabash, IN) was used for pellet compaction. During the agglomeration stage, all or part of the API is mixed with fillers and a granulating binder to obtain a uniform mixture. During mixing, a small amount of water (1–4% of the weight of the entire formula) is sprayed onto the powder blend, thus enabling the water droplets to moisten the binder to make it moist and tacky. The API and excipient particles bind together as the mixer impellers or blades move them in a circular motion. The resulting agglomerates are small, spherelike granules with a typical particle size of 150–500 μm. In the next stage of the process, moisture absorbents such as microcrystalline cellulose or silicon dioxide are added while mixing continues. The entire mixture becomes drier as some of the water in the moist agglomerates is released to the moisture absorbents. The agglomerates remain largely intact during the moisture-distribution stage, although the larger particles often break up. Disintegrant is added to the mixture at this stage and blended. Then, while mixing continues, lubricant is added and blended for sufficient time to achieve adequate lubricity. This completes the MADG granulation process, which takes about 15 min.
विगत अनेक वर्षो से किसानो द्वारा समय समय पर सरकारो से अपनी समस्याओ का स्थायी समाधान निकालने की मांग की गई। किन्तु सरकारो द्वारा इसका स्थायी हल निकालने मे कोई रुचि नही दिखाई । दिनोदिन किसानो की परेशानी बढ़ती रही। पिछले कुछ समय से किसानो को कुछ उम्मीद बनी कि, अब शायद उसकी समस्याए समाप्त होगी किन्तु जब यह उम्मीद टूटने लगी तो देश के किसानो मे आक्रोश फैला। अभी हाल ही मे कृषि उत्पाद के दाम समर्थन मूल्य से नीचे आ गए, सरकार द्वारा खरीद कि पर्याप्त व्यवस्था नही थी, भुगतान भी नही हो रहा था। ऐसे अनेकों कारणो से किसान आंदोलन के लिए उद्वेलित हुये। इन सब बातो को देखते हुये भारतीय किसान संघ ने भी कई प्रांतो मे आंदोलन शुरू किए। लेकिन भारतीय किसान संघ का यह सिद्धान्त है कि, हम हमेशा देशहित का ध्यान पहले रखेंगे। आंदोलन शांतिपूर्ण रहेगा, उसमे हिंसा नही होने देंगे तथा कार्यकर्ता पूर्ण अनुशासन मे रहेंगे। लेकिन आंदोलन मे मालवा मे जब हमारे आंदोलन मे कुछ बाहरी तत्व शामिल होकर हिंसा फैलाने कि जानकारी हुई तथा उसी समय सरकार द्वारा क्षेत्रीय मांगो को मान्य कर लिया गया, तब आंदोलन वापस लिया गया। हमे प्राप्त सूचना सच साबित हुई तथा उन तत्वो द्वारा हिंसा फैलाने का प्रयास किया गया। तमिलनाडू, महाराष्ट्र, राजस्थान मे भी आंदोलन हुये। राजस्थान मे भारतीय किसान संघ द्वारा किया गया आंदोलन भी अनुशासनबद्ध और अहिंसक रहा किन्तु स्वरूप बड़ा होने से अंत मे सरकार को झुकना पड़ा तथा किसानो कि सभी मांगे मान ली गई।इसके बावजूद अभी भी किसानो मे बहुत आक्रोश व्याप्त है। इस पर हम सतत विचार कर रहे है। भारतीय किसान संघ कि स्थापना से ही यह मान्यता रही है कि, किसान को उसकी उत्पाद का लागत मूल्य तथा उस पर लाभांश जोड़कर लाभकारी मूल्य प्राप्त होना चाहिए। लेकिन दुर्भाग्य से देश मे कई सरकारे आने जाने के बाद भी अभी तक लाभकारी मूल्य प्राप्त नही हो सका। देश मे कृषि उत्पाद आयात निर्यात कि अब तक कोई ठोस नीति नही बन सकी। लिसके अभाव मे कृषि उत्पाद का जो आयात निर्यात होता है उसमे किसान हित को कोई महत्व नही दिया जाता है। जिसका परिणाम यह होता है कि बम्पर फसल आने के बावजूद या तो निर्यात प्रतिबन्धित किया जाता है या आयात किया जाता है। दोनों ही परिस्थितियो मे कृषि उत्पाद के मूल्य धराशायी हो जाते है और किसान ठगा सा रह जाता है। इस वर्ष ऐसा ही दलहन के मामले मे हुआ। किसान के उत्पादन का सरकार द्वारा घोषित समर्थन मूल्य से बाज़ार मे जब उक्त उत्पाद का दाम कम होता है तब उसकी पूर्ति के लिए सरकार द्वारा एक मूल्य स्थिरीकरण कोष बनाकर, भावांतर योजना तत्काल लागू कि जाए। जैसा कि मध्य प्रदेश एवं आंधप्रदेश मे किया गया है। खाद्य प्रसंस्करण, पशुपालन एवं डेरी आदि को बढ़ावा देकर गावों से होने वाले पलायन को रोका जा सकता है। जिससे ग्रामीण युवाओ को रोजगार के अवसर, गावों मे ही उपलब्ध होंगे और नशे एवं अपराधो पर भी अंकुश लगेगा। ऐसी गंभीर परिस्थिति मे सरकार को हड़बड़ाहट मे कर्जमाफ़ी का निर्णय न लेकर, देश के सभी किसानो को प्रति एकड़ एक निश्चित राशि तय कर सीधे उनके खाते मे जमा करने कि योजना बनाकर उसे तत्काल लागू करना चाहिए। उपरोक्त सभी बिन्दुओ को ध्यान मे रखते हुए केंद्र एवं राज्य सरकारे संसद एवं विधान सभाओ का विशेष सत्र बुलाकर, किसान संगठनो का सहयोग लेकर, राजनैतिक मतभेद भूलकर, भारत एक कृषि प्रधान देश है इस वाक्य को चरितार्थ करने के लिए, कृषि क्षेत्र के लिए समग्र कृषि रोड मैप तैयार करे। तभी किसान कि समस्याओ का स्थायी समाधान हो सकेगा।
That no free government, or the blessing of liberty, can be preserved to any people but by a firm adherence to justice, moderation, temperance, frugality, and virtue, and by frequent recurrence to fundamental principles. Topics: Liberty, Government Wondering Whom to Read Next? - James Madison American Statesman, President - Thomas Jefferson American Head of State - John Marshall American Judge - George Washington American Head of State - Martha Washington American First Lady - Robert E. Lee American Military General - John Randolph American Politician - Jane Addams American Social Reformer - Charles Mingus American Jazz Bassist, Composer - Raymond Chandler American Novelist
फाइनेंशियल टाइम्स की खबर के अनुसार प्रधानमंत्री बोरिस जॉनसन की सरकार एक घरेलू कानून की योजना बना रही है जो उत्तरी आयरलैंड के ब्रिटिश क्षेत्र और यूरोपीय संघ के सदस्य आयरलैंड के बीच खुली सीमा बनाए रखने की प्रतिबद्धताओं को कमतर करने से संबंधित है। 1481 ग्रेगोरी कैलंडर का एक साधारण वर्ष है। अभियोजक ने ब्रिटेन की इस अदालत को बताया कि सउदी अरब में समलैंगिकता अवैध है और इस आरोप में मौत की सजा भी हो सकती है। (भाषा) इसलाम. नहीं हुआ तो न्यायालय का लेंगे सहारा कोरोना महामारी की दूसरी लहर के कमज़ोर पड़ने के साथ ही एक और अच्छी ख़बर इस वक़्त में आई है। ख़बर यह है कि ड्रंग कंट्रोलर जनरल ऑफ़ इंडिया (डीसीजीआई) ने शुक्रवार को सीरम इंस्टीट्यूट ऑफ़ इंडिया को भारत में रूस की वैक्सीन स्पुतनिक बनाने की अनुमति दे दी है। यह तीसरी वैक्सीन होगी, जो भारत में बनाई जाएगी। खुद के साथ की थी पूल पार्टी पिछले साल बॉलीवुड एक्ट्रेस सुष्मिता सेन ने अपने ब्वॉयफ्रेंड रितिक भसीन से ब्रेकअप कर लिया। वे दोनों पिछले चार सालों से एक दूसरे को डेट कर रहे थे। बताया जाता है कि इतने कम वक्त में ही दोनों का रिश्ता कई बार टूटने की कगार पर</s>
Many human cancers, particularly gliomas and acute myelogenous leukemia (AML), contain mutations in the genes IDH1 or IDH2, which encode two isoforms of the metabolic enzyme isocitrate dehydrogenase (1, 2). These mutant enzymes produce the (R)-enantiomer of 2-hydroxyglutaric acid [(R)-2HG], a molecule that inhibits histone- and DNA-modifying enzymes, thereby altering gene expression and promoting the acquisition of malignant features (3–5). Reports by Losman et al. (6) as well as by Wang et al. (7) and Rohle et al. (8) on pages 622 and 626 of this issue, respectively, find that inhibitors of the mutant forms of IDH1/2 suppress the growth of (R)-2HG–producing tumor cells (6–8). The findings imply that curtailing (R)-2HG supply normalizes gene expression and reverses malignancy.
भी हुई थी। खतरों के खिलाड़ी में कई बार कंटेस्टेंट टास्क के दौरान घायल हो जाते हैं। तबेले में सोया था युवक, बदमाशों ने चाकू से गोदकर किया घायल, मारी गोली जानकारी के अनुसार जैसलमेर सदर पुलिस थाने में तैनात कांस्टेबल आत्माराम की फेसबुक आईडी हैक हो गई है। हैकर ने उसकी फेसबुक प्रोफोइल में नाम बदलकर एलेक्स मोर्गन कर दिया है। इसके साथ ही उसे कमांडो बताया गया है। फेसबुक आईडी में उसका पता बदलकर अफगानिस्तान के काबुल का निवासी बताया है। गौरतलब है कि राजस्थान के सीमावर्ती इलाके जैसलमेर में लोगों की फेसबुक आईडी हैक किए जाने का सप्ताहभर में यह दूसरा मामला है। कांस्टेबल से पहले एक युवक की आईडी हैक कर ली गई थी। भीख मांगकर कर रहे गुजारा बता दे की पूर्व में मुंबई की बांद्रा कोर्ट में अरबाज व मलाइका का तलाक हो चूका है तथा अब यह दोनों ही अलग अलग रह रहे है. दोनों को तलाक आपसी मंजूरी पर दिया गया है. अब मलाइका के साथ में अपने सारे रिश्ते नाते तोड़ने के बाद अब एक बार फिर से अरबाज की पूर्व पत्नी मलाइका अरोरा सुर्खियों में चल रही है. बीजेपी और शिवसेना के रिश्तों को लेकर भी कई कार्टून बनाए गए</s>
Not a member yet? Join now Whichever way the vote goes, today is a historic day for Britain and for the EU. Let's cast an InterNations vote and see what we think it may happen. R=RemainL=Leave I bet on remain, so the score is Protected content . Cast your vote, add it to the previous score and write the total. Let's vote! :) PS: If what you THINK will happen is different from what you WANT to happen, please vote for what you WANT to happen. This way we may get a more accurate result.
The information below pertains only to real property as opposed to personal property. As a property owner, you should be diligent in regard to your property and finances. What follows is important information provided by the FB All parties to a real estate transaction are potential targets of wire fraud and may lose hundreds of thousands of dollars because they simply relied on the wire instructions received via email, without further verification. If funds are to be wired in conjunction with this real estate transaction, it is strongly recommended that verbal verification of wire instructions, through a known trusted phone number made prior to sending funds. - Never rely on emails purporting to change wire instructions. Parties to a transaction rarely change wire instructions in the course of a transaction. - Always Verify wire instructions, specifically the routing number and account number, by calling the party who sent the instructions to you. Do not use the phone number provided in the email containing the instructions, use phone numbers you have called before or can otherwise verify. Obtain the phone number of relevant parties to the transaction as soon as an escrow account is opened. Do not send an email to verify as the email address may be incorrect or the email may be intercepted by the fraudster. - Use complex email passwords that employ a combination of mixed case, numbers, and symbols. Make your passwords greater than eight (8) characters. Also, change your password often and do NOT reuse the same password for other online accounts. - Use multi-factor authentication for email accounts. Your email provider, or IT staff, may have specific instructions on how to implement this feature. This is a type of Financial institution fraud and is characterized by some type of material misstatement, misrepresentation, or omission in relation to a mortgage loan which is then relied upon by a lender. A lie that influences a bank’s decision about whether, for example, to approve a loan, accept a reduced payoff amount, or agree to certain repayment terms is mortgage fraud. There are two distinct areas of mortgage fraud. Fraud for profit: Those who commit this type of mortgage fraud are often industry insiders using their specialized knowledge or authority to commit or facilitate the fraud. Fraud for profit aims not to secure housing, but rather to misuse the mortgage lending process to steal cash and equity from lenders or homeowners. Fraud for housing: This type of fraud is typically represented by illegal actions taken by a borrower motivated to acquire or maintain ownership of a house. The borrower may, for example, misrepresent income and asset information on a loan application or entice an appraiser to manipulate a property’s appraised value. Common Examples of mortgage fraud. - Title Transfer: The most dangerous scheme is the “bailout” that never quite works. This scenario includes various schemes in which the homeowner surrenders title to the house in the belief that within the deal, they’ll be able to remain in the home as a renter, and eventually buy it back. Homeowners are sometimes told that surrendering title is necessary so that someone with a better credit rating can secure new financing to prevent the loss of the home. But the terms of these deals are almost invariably so onerous that the buyback becomes impossible, the homeowner loses possession permanently, and the “rescuers” end up with all or most of the home’s equity, often evicting the original homeowner. Another scam convinces the homeowner to transfer title to a “federal land grant” with the false promise that this prevents the lender from foreclosing. - Foreclosure rescue schemes: The perpetrators identify homeowners who are in foreclosure or at risk of defaulting on their mortgage loan and then mislead them into believing they can save their homes by transferring the deed or putting the property in the name of an investor. The perpetrators profit by selling the property to an investor or straw borrower, creating equity using a fraudulent appraisal, and stealing the seller proceeds or fees paid by the homeowners. The homeowners are sometimes told they can pay rent for at least a year and repurchase the property once their credit has been reestablished. However, the perpetrators fail to make the mortgage payments and usually the property goes into foreclosure. - Loan modification schemes: Similar to foreclosure rescue scams, these schemes involve perpetrators purporting to assist homeowners who are delinquent in their mortgage payments and are on the verge of losing their home by offering to renegotiate the terms of the homeowners’ loan with the lender. The scammers, however, demand large fees up front and often negotiate unfavorable terms for the clients, or do not negotiate at all. Usually, the homeowners ultimately lose their homes. - Equity skimming: An investor may use a straw buyer, false income documents, and false credit reports to obtain a mortgage loan in the straw buyer’s name. Subsequent to closing, the straw buyer signs the property over to the investor in a quit claim deed, which relinquishes all rights to the property and provides no guaranty to title. The investor does not make any mortgage payments and rents the property until foreclosure takes place several months later. - Silent second: The buyer of a property borrows the down payment from the seller through the issuance of a non-disclosed second mortgage. The primary lender believes the borrower has invested his own money in the down payment, when in fact, it is borrowed. The second mortgage may not be recorded to further conceal its status from the primary lender. - Home equity conversion mortgage (HECM): A HECM is a reverse mortgage loan product insured by the Federal Housing Administration to borrowers who are 62 years or older, own their own property (or have a small mortgage balance), occupy the property as their primary residence, and participate in HECM counseling. It provides homeowners access to equity in their homes, usually in a lump sum payment. Perpetrators taking advantage of the HECM program recruit seniors through local churches, investment seminars, and television, radio, billboard, and mailer advertisements. The scammers then obtain a HECM in the name of the recruited homeowner to convert equity in the homes into cash. The scammers keep the cash and pay a fee to the senior citizen or take the full amount unbeknownst to the senior citizen. No loan payment or repayment is required until the borrower no longer uses the house as a primary residence. In the scheme, the appraisals on the home are vastly inflated and the lender does not detect the fraud until the homeowner dies and the true value of the property is discovered. - Commercial real estate loans: Owners of distressed commercial real estate (or those acting on their behalf) obtain financing by manipulating the property’s appraised value. Bogus leases may be created to exaggerate the building’s profitability, thus inflating the value as determined using the ‘income method’ for property valuation. Fraudulent appraisals trick lenders into extending loans to the owner. As cash flows are lower than stated, the borrower struggles to maintain the property and repairs are neglected. By the time the commercial loans are in default, the lender is often left with dilapidated or difficult-to-rent commercial property. Many of the methods of committing mortgage fraud that are found in residential real estate are also present in commercial loan fraud. Signs for Real Estate Fraud: Anyone can be vulnerable to real estate fraud and identity theft, however, the elderly and economically challenged traditionally have been targeted. Below are some common warning signs of real estate fraud: - You receive official documents indicating a transfer of your property and you have no knowledge of the transaction; - You did not receive a property tax bill. This can be the first sign of fraud; and - You receive mortgage documents or payment books for loans for which you never applied. Please see our other related articles Disclaimer: Every situation is different and particular facts may vary thereby changing or altering a possible course of action or conclusion. The information contained herein is intended to be general in nature as laws vary between federal, state, counties, and municipalities and therefore may not apply to any given matter. This information is not intended to be legal advice or relied upon as a legal opinion, course of action, accounting, tax or other professional service. You should consult the proper legal or professional advisor knowledgeable in the area that pertains to your particular situation.
Medical Definition of Diastrophic dysplasia Diastrophic dysplasia: An inherited skeletal disorder involving significantly short stature (dwarfism). Characteristic features at birth include short birth length with short limbs (short-limbed dwarfism), "hitchhiker thumb", and clubfeet. Palatal malformations such as cleft palate or submucous cleft of the palate are present in 50% of patients. There is swelling of the ears in the first days to weeks of life in 80% of children; the swelling then spontaneously subsides but later the ears have a "cauliflower" appearance. Fingers are short and broad and show ulnar deviation (are inclined away from the thumb). The thumb itself has a hitch-hiker-type appearance. There is increased death rate in infancy due to problems breathing, but thereafter people with diastrophic dysplasia have a normal life span. Orthopedic problems are common. The joints can be dislocated, especially the shoulder, elbows, hips, and patellae (knee caps). Flexion contractures of the knees and shoulders are common. Scoliosis (sideways curvature of the spine) is not present at birth but often develops and is progresses particularly in the early teen years. Treatment of the scoliosis includes bracing and occasionally, spinal fusion. Progressive kyphosis (forward bending of the spine) can also occur with what is called subluxation (slippage) which can result in compression of the spinal cord. The average length of babies with diastrophic dysplasia at birth is 16 1/2 inches (42 cms). The average adult height is slightly under 4 feet -- 46-47 inches (118 cms) to be exact. The final adult height is influenced by the presence of scoliosis, hip contractures and knee contractures, and foot deformities. Diastrophic dysplasia is inherited as an autosomal recessive condition meaning that the gene for diastrophic dysplasia is on one of the nonsex chromosomes and average-sized parents have a 1 in 4 (25%) chance of having additional children with diastrophic dysplasia. The gene for diastrophic dysplasia is on chromosome 5q32-q33.1 and is called "diastrophic dysplasia sulfate transporter" (DTDST). Prenatal diagnosis has been performed for diastrophic dysplasia by ultrasound and by molecular DNA diagnosis to detect DTDST. Diastrophic dysplasia was first clearly delineated by Maroteaux and Lamy in France in 1960. The term "diastrophic" was borrowed by Lamy and Maroteaux from geology: diastrophism is the process of bending of the earth's crust by which mountains, continents, ocean basins, etc., are formed. Dysplasia means abnormal in form.Source: MedTerms™ Medical Dictionary Last Editorial Review: 6/9/2016 Medical Dictionary Definitions A - Z Search Medical Dictionary
: Deep vein thrombosis (DVT), a frequent complication of spinal cord injury, is occasionally caused by neurogenic heterotopic ossification (NHO). In most cases of NHO, the hip joint is affected. Herein, we present a case of paraplegia following radiation-induced myelopathy that presented with left leg swelling due to DVT in the common iliac vein (CIV) caused by venous compression by NHO on the anterior lower lumbar spine. : A 28-year-old man with complete paraplegia due to radiation-induced myelopathy presented with left lower extremity swelling 6 years after the onset of paraplegia. DVT in the left CIV was observed on computed tomography venography. The left CIV was significantly compressed between the NHO at the anterior longitudinal ligament of the lumbar spine and the right common iliac artery, suggestive of May-Thurner syndrome. Slightly distal to that compressed area, the left CIV was significantly compressed by the large NHO at the anterior longitudinal ligament of the lumbar spine. : We believe that such compression of the left CIV would have contributed to the development of DVT. This case shows that DVT might be caused by NHO at the anterior aspect of the lumbar vertebral body, and this may help clinicians identify the main cause of DVT in the leg.
Strengthening of Small Lebanese Economic Actors through a Range of Services Number of Beneficiaries: Integrating support for ecological transition and innovative and adapted financial products- Tarik Akhdar Nurturing Prosperity: Our project’s grand vision was to ignite a renaissance in Lebanon‘s rural and agricultural economy, championing responsible growth and sustainable approaches. Our tailored goals encompassed empowering cooperatives and micro-enterprises to embrace eco-friendly practices, while enhancing the capacities of FTL, FTTL, and Al Majmoua to amplify Fair Trade‘s reach and foster ecological and social transitions. A substantial impact awaits, benefiting over 1123 individuals, including 562 remarkable women, paving the way for a brighter future.
पटना। मैं तेरी दुनिया छोड़ चला मोबाइल पर यह गाना फुल साउंड में बजाकर अपने पॉकेट में रखा और गले में फंदा डालकर पेड़ से झूल गया। आत्महत्या करने का यह तरीका देखकर गांव वाले भी चकरा गए। लोगों ने युवक को देखा तो पेड़ से उतारा, तबतक उसकी मौत हो चुकी थी। घटना पटना के दुल्हिनबाजार की है, जहां शुक्रवार की देर शाम एक युवक ने एनएच-९८ के मुख्य पथ के किनारे स्थित एक पेड़ में फांसी का फंदा डालकर लटक गया और अपनी जान दे दी। लोगों ने इसकी सूचना पुलिस को दी, पुलिसशव जब्त कर मामले की जांच कर रही है। मिली जानकारी के मुताबिक मृतक युवक रानीतालाब थाना क्षेत्र के निसरपुरा गांव निवासी वंशी मांझी का पुत्र हरिया मांझी (३५) है। बताया जाता है कि युवक मंदबुद्धि था और हाल ही में उसकी शादी हुई थी। पत्नी को जब पता चला कि उसका पति मंदबुद्धि है तो वह उसे छोड़कर चली गई थी। युवक इसके बाद डिप्रेशन में रहता था। कल शाम वह घर से निकलकर चुपचाप सड़क के किनारे बैठा था और मोबाइल से गाना सुन रहा था। उसके बाद उसने मोबाइल पॉकेट में डाल पेड़ से लटककर अपनी जान दे दी। उसका शव संदिग्ध स्थिति में निसरपुरा चैनपुरा गांव के समीप पीपल के पेड़ से लटका मिला। पुलिस शव बरामद करने के बाद मामले की जांच कर रही है। परिजनों ने कोई लिखित शिकायत नहीं की है।
A Complete Guide to Install SSL certificate in Tomcat Server. Tomcat also knew as Apache tomcat is a well-renowned name in the network category. Its popularity lies in being an open source web server by Apache Software Foundation. It basically supports Java-based applications (Java server pages (JSP) and Java servlets) by being a pure Java HTTP web server. You should follow instructions to installing SSL certificate in Tomcat. Generating Certificate Signing Request (CSR): Before obtaining a Certificate from SSL2BUY, you need to create a CSR. With the help of this CSR, the CA will issue the certificate identifying your website as secured. Below are the steps given to creating a CSR: Local certificate creation: keytool -genkey -alias tomcat -keyalg RSA -keystore <your_keystore_filename> Note: In the few cases, you will have added the domain of your website (for e.g. www.yoursite.org) in the “first-and lastname” fields for creating a working certificate. Now, for creating the CSR, type the following command: keytool -certreq -keyalg RSA -alias tomcat -file certreq.csr -keystore <your_keystore_filename> Now you have a file named certreq.csr that you can present to the Certificate Authority. CA certification installation using X.509 format - Select proper primary and secondary intermediate certificate. - Copy-paste the contents of primary and secondary intermediate certificate in two separate text files, of course. Make sure that there are no white spaces, line breaks and extra lines in the file. - Name the primary intermediate certificate text file as primary-inter.cer - To import the above certificate into the keystore uses the following command keytool -import -trustcacerts -alias primaryIntermediate -keystore your_keystore_filename -file primary_inter.cer - Name the secondary intermediate certificate text file as secondary_inter.cer. - In order to import the certificate, use the following command into the keystore. keytool -import -trustcacerts -alias secondaryIntermediate -keystore your_keystore_filename -file secondary_inter.cer Install SSL certificate You have to download or copy-paste the certificate which you have received through e-mail. For the certificate which is emailed as an attachment, download and use it as it is. For the certificate which is forwarded as in text format; copy and paste it into a text file. Please do not use Microsoft Word for this purpose as it will enumerate extra characters. Also, make sure that there are no white spaces or extra lines in the file. It will look something like this: -----BEGIN CERTIFICATE----- [encoded data] -----END CERTIFICATE----- The five dashes after and before “Begin Certificate” & “End Certificate” are compulsory. There should be no white spaces, line breaks, and additional certificates. Type the command to import the SSL certificate as given below: Keytool -import -trustcacerts -alias your_alias_name -keystore your_keystore_filename -file your_certificate_filename Note: The alias name should not be different from that mentioned during the generation of the private key and CSR. Verify the contents of the Certificate To list the contents of the keystore please type the following command: keytool -list -v -keystore your_keystore_filename >output_filename You will be able to view the content of the output in the following manner: The SSL certificate should be imported under the alias “Entry Type” of PrivateKeyEntry or KeyEntry, if it is not so then please import it into the Private Key alias. To enable SSL configuration your server.xml file - Open the server.xml config file in the text editor. - Search for the secure element in your config file (try searching for SSL Connector). By default, it should look something like this: <-- SSL Connector on Port 8443 --> <!-- <Connector className="org.apache.coyote.tomcat4.CoyoteConnector" port="8443" minProcessors="5" maxProcessors="75" enableLookups="false" acceptCount="10" connectionTimeout="60000" debug="0" scheme="https" secure="true"> <Factory className="org.apache.coyote.tomcat4.CoyoteServerSocketFactory" clientAuth="false" protocol="TLS" keystoreFile="insert path to the keystore here"> keystorePass="insert keystore password here"> </Connector> --> - Make sure the “keystoreFile” directive is citing the correct keystore and the “keystorePass” directive is addressing the correct keystore password. NOTE: These directives are case-sensitive! Make sure the letters “F” and “P” in “keystoreFile” and “keystorePass” are in upper case. - If your keystore contains more than one private key alias, please add the “keyAlias” directive to reference the correct private key alias name. keystoreFile=”insert path to the keystore here” keystorePass=”insert keystore password here” keyAlias=”insert private key alias here”/> - Save the changes. - Stop and Restart Tomcat In order to verify the contents of the certificate, use the installation checker. For further information, please refer to the Tomcat Web site.
Design of Intelligent Thin-Walled Composite Beams This paper reports a further study on the design of intelligent thin-walled composite beams using piezoelectric materials to actively control their transient vibrations. A theorem of sensibility is proved to establish the sensibility of modal vibration by distributed sensors. In the case of non-exact sensing, a sensing residual is defined to quantify the error in motion sensing. Distributed actuators are designed based on the principle of moment excitation. Actuating spill over is also defined to quantify the error in motion actuation. A theorem of sensing residual is discovered, which reveals the physical nature of the sensing residual and its effect on active controlling process. An application example is presented.
Japan was in the forefront of tank technology in the 1930s, introducing a number of innovations such as diesel tank engines. Tank production in the 1930s was also much greater than that of many European armies, due to the conflict in China. In the period 1931 - 1938, the Japanese had built nearly 1,700 tanks, which put them into fourth place in the world behind only the Soviet Union, France and Germany. \| By the time the Japanese started their war with China in 1937, they had eight tank regiments in the field. \| Japanese tank units played a key role in the early victories of December 1941- January 1942 against the US Army in the Philippines and the British Army in Malaya. Despite their success, after 1941, the shift in strategic focus of the Japanese war effort changed industrial priorities from the needs of the army \| to warship and aircraft construction, so tank production fell in the later years of the war. \| However, Japan did continue to build tanks, even to increase output during 1940 and 1941. But after reaching peak annual production in 1942 the tank building industry declined and was unable to catch up. Japan's most modem tanks were reserved for a last-ditch defense of the Home Islands in 1945 - a final battle that never took place.
from board import Board class Game: def __init__(self, player_x, player_o): self._board = Board() self._player_x = player_x self._player_o = player_o self._current_player = player_x def run_game(self): # print("Starting a new game.") is_game_complete = False winner_symbol = None while not is_game_complete: self._board.print_board() move_tuple = () current_player_symbol = self.__get_player_symbol(self._current_player) non_current_player_symbol = self.__get_player_symbol(self.__get_non_current_player()) while not self._board.make_move(move_tuple, current_player_symbol): move_tuple = self._current_player.move(self._board, current_player_symbol, non_current_player_symbol) self.__get_non_current_player().update_opponent_move(self._board, non_current_player_symbol, current_player_symbol) is_game_complete, winner_symbol = self._board.check_game_complete_and_get_winner_symbol() self.__switch_player() self.__forward_match_winner_results(winner_symbol) if winner_symbol: print("Player {player_symbol} won.".format(player_symbol=winner_symbol)) else: print("It's a draw.") def __get_non_current_player(self): return self._player_x if self._current_player == self._player_o else self._player_o def __forward_match_winner_results(self, winner_symbol): self._player_x.receive_game_results('x', winner_symbol) self._player_o.receive_game_results('o', winner_symbol) def __get_player_symbol(self, player): if player == self._player_x: return "x" elif player == self._player_o: return "o" def __switch_player(self): self._current_player = self._player_o if (self._current_player == self._player_x) else self._player_x
- Setting up your NEEO for the first time - Is the NEEO app needed for setup? - NEEO can't find my Wi-Fi network - Can I use NEEO with my own power supply? - How can I create a NEEO Account? - Can you add support for my favorite devices? - Do you have a community? - How can I join the BETA Team? - Can I use NEEO without internet connection? - Does my Smartphone and the NEEO Brain needs to be in the same Network? - Where can I find the serial number? - If I have two NEEO Remotes will one over-rule the other? Ask our community Get help from our friends on Planet NEEO, the place to share your stories, ideas and requests.visit planet neeo
ढाई माह की है और उनके पास बिस्तर पर ही थी। गांव निवासी टेड़ई के दो बैल भी करंट की चपेट में आने से मर गए। 25 से 30 घरों के बिजली के उपकरण जल गए। इससे लोगों को दो लाख रुपये से अधिक का नुकसान हुआ। कई घरों की वायरिंग जल गई। ग्रामीणों का कहना है कि 33 हजार वोल्टेज के तार के ढेर नीचे लटक जाने व जर्जर हो जाने की जानकारी लिखित रूप से दो माह पूर्व विजली बिभाग के अधिकारियों को दी गई थी। लेकिन विभागीय अधिकारियों व कर्मचारियों की लापरवाही के चलते घटना घट गई। ग्राम प्रधान इंद्रावती देवी ने बताया की जर्जर तारों से की जा रही बिजली आपूर्ति के विषय में बिजली विभाग के अधिकारियों को अवगत कराया गया था फिर भी उसको नहीं सुधरवाया गया। बरसात के दिनों में करंट से ज्यादा खतरा बना है। इसलिए जर्जर तारों की मरम्मत करानी चाहिए, पर विभाग पहल नहीं कर रहा है। इसके लिए आंदोलन किया जाएगा। मुंबई। अमिताभ बच्चन ( ) फिलहाल कौन बनेगा करोड़पति सीजन 12 () होस्ट कर रहे हैं। इसके लिए उन्हें करीब 1517 घंटे काम करना पड़ रहा है। बिग बी शूटिंग में इतने बिजी हैं कि कई बार वो</s>
Bright lights in the big city – Buenos Aires never fails to stun with its beautiful architecture and unique rhythm © alex_black, Shutterstock Part New York, part Paris, but all Buenos Aires, this vast city never gives a dull first impression. Beautiful European architecture stands among the bland North American-style high-rise buildings, garish neon lights and advertising billboards. Cobbled old artisan streets lead to 21st-century docklands development, and then to a riverside wilderness. The energy of big-city traffic and gridlock, the pulsing nightlife where dinner can start at midnight, and the large and long-established metro system imply prosperity – though there’s bleak backstreet poverty too. The city’s inhabitants came to be referred to as porteños or port residents, a great mix of Italian, Spanish, British, Jewish, Afro-Argentine, German, and Portuguese immigrants. It is a unique city within Argentina and the people even have a characteristic accent that differs from the rest of the country. The city effortlessly blends South American colour, rhythm and spice with European elegance, style and sophistication and North American economic and commercial ambitions, all the while maintaining a culture, a language, folklore, music and dance that is purely Argentine, and distinctly porteño. And yes, tango really is everywhere, from the gaudy street-dancer kitsch of Caminito to the urgent city-music fusion pouring out of shops and restaurants. The city is referred to as the Capital Federal, or sometimes the Ciudad Autónoma de Buenos Aires or Autonomous City of BA, or shortened to ‘BsAs’. It has a population of over three million; the metropolitan area of Gran Buenos Aires, also known as the Gran Aldea (great village), includes the Capital Federal and surrounding districts, or partidos, and reaches a population of 13 million. Around 1910, Buenos Aires became the first South American city to reach a population of one million; its inhabitants came to be referred to as porteños or port residents, a great mix of Italian, Spanish, British, Jewish, Afro-Argentine, German, and Portuguese immigrants. It is a unique city within Argentina and the people even have a characteristic accent that differs from the rest of the country. Buenos Aires was actually founded twice, some say even three times. The first was in 1536, by Pedro de Mendoza, leading one of the first Spanish expeditions to Argentina. He arrived at a large estuary that had been previously claimed by Juan Díaz de Solís in 1516 on the first, and unfortunately fatal, expedition to Argentina, sailing down from Brazil in search of a southern passage to the Pacific. This second voyage followed the fall of the Inca Empire in 1532; the King of Spain, Carlos I, sent Mendoza’s group to counter Portuguese advances in the territory. The group was able to settle on the southwestern bank of the estuary, and the settlement was soon named Nuestra Señora Santa María del Buen Aire. However, the native Americans who were long established in the area did not perceive their lands as available for settlement. Their warriors, who had already become skilled horsemen, launched repeated attacks upon the settlement and any exploration parties it attempted to send out. Shortage of food and supplies led Mendoza to abandon the settlement in 1537. It was not until 1580 that Buenos Aires was founded for the second time at the ‘River of Silver’ (Río de la Plata, or River Plate) by Juan de Garay. His intention was to establish the Río de la Plata as a gateway for trade. It was during these early days of pioneering the pampas that the leather and beef industry was born, and so was born the famous gaucho or Argentine cowboy. Rudimentary plans for a town took shape with streets laid out in a grid. In the centre was established the Plaza Mayor, today the Plaza de Mayo, and a fort was erected on the site where the Executive Office Building now stands. Buenos Aires was subordinate to Asunción, which was in turn subordinate to the Viceroyalty of Lima, which was subordinate then to Madrid, the Spanish capital; it would take a couple of centuries for Buenos Aires to grow and match Lima’s level of power and status. Meanwhile, it was cut off from communication with Spain owing to colonial and mercantile bureaucracy. The large trading fleets from Spain would stop in Cuba and at Portobello on the Isthmus of Panamá, send their goods by mule across the isthmus to the Pacific and load them onto fresh ships for Callao, near Lima. This route was relatively safe from attack but very lengthy and costly and Buenos Aires was quite neglected. Buenos Aires was only permitted to receive registered ships, sailing only every year or so, and up to five years could pass without a registered ship arriving from Spain. The porteños in those days suffered greatly under this system; culturally they could not adapt to the Querandí’s hunting-and-gathering lifestyle, and it was inevitable that bootlegging would become a means of survival. Against Spanish authorisation, the porteños began trading with the British and Portuguese vessels that passed; and what they had to trade was leather. Cattle and horses abandoned by the Mendoza expedition had by this time grown into semi-wild herds that populated the pampas. The leather was too crude to trade with Spain, but it was acceptable for contraband trade. It was during these early days of pioneering the pampas that the leather and beef industry was born, and so was born the famous gaucho or Argentine cowboy. The colourful street museum and alley of Caminito in the La Boca neighbourhood © Luis Argerich, Wikipedia The increase in commercial activity, smuggling and the slave trade caused Buenos Aires to expand. By 1776, its population exceeded 25,000; Spain had come to recognise the importance of Buenos Aires and in that year made it the capital of the newly created Viceroyalty of the River Plate, which included the wealthy silver region of Potosí (in present-day Bolivia). In 1778, the Atlantic ports were allowed to trade freely, giving a big boost to the city’s growth. In 1800, the British Empire began implementing its colonial expansion policies and the Río de la Plata was in its sights as a potential British base for trade. The first attack on Buenos Aires in 1806, led by Commander Beresford, was opposed by Spanish troops led by Santiago de Liniers from Montevideo (taking command in the absence of Viceroy Rafael de Sobremonte, who had fled at the onset of the attack), together with an urban militia of Spanish civilians, Creole patricios and peasant gauchos. The battle was short and the British force surrendered and was interned in Luján. A second ill-advised attack in July 1807 by 10,000 men under Major-General John Whitelock was repelled by the heroic defence of the urban militia, aided by women and children using such tactics as pouring boiling oil and water from windows and rooftops and firing cannons from balconies (in particular the balcony of Defensa 372, now the Museo Nacional del Grabado). Whitelock’s headstrong frontal attack on the fortified city resulted in the immediate loss of almost a third of his men. He accepted a truce offered by Liniers and was evacuated to Montevideo, from where he returned to Britain to face court martial. These battles are known as La Reconquista and La Defensa and were remarkable because the residents themselves, the porteños, organised their own defence without the aid of the colonial power and with decisions being made without reference to Madrid or intervention from the viceroy. Meanwhile in Europe, Napoleon had crossed Spain to invade Portugal (allied with Britain) with the assistance of Charles IV; Charles was forced to abdicate and was replaced on the throne by Ferdinand. Napoleon forcibly re-established Charles as king, in order for Charles to then yield it to Napoleon, who then put his brother Joseph on the Spanish throne. This created anti-French sentiment in Buenos Aires leading to the execution of Liniers solely on the basis of his French name. On 25 May 1810, the citizens of Buenos Aires revolted and disposed of Viceroy Sobremonte for he was seen as a coward and not capable of protecting the River Plate. The May Revolution of 1810 replaced him with an autonomous governing body. Buenos Aires itself had reached a population of over 300,000, and recognisable neighbourhoods, barrios, had been established. Some consider the city to have had a third founding with mass immigration in the late 19th century. A century later, Buenos Aires’s population had grown eightfold and the city was modern and cosmopolitan. The first subway line (the first in Latin America) opened in 1911, and the city’s first skyscraper, the Barolo Building, appeared in 1920. By 1950, Buenos Aires was one of the largest cities in the world.
The Deity and Ministry of the Holy Spirit looks at who is the Holy Spirit and what role does He play in the Trinity and in the life of the Christian? This five part series explores the above question and reveals the vital ministry the Holy Spirit performs at salvation and continuing in the believers journey to maturity. The teachings include: - The Deity of the Holy Spirit - The Holy Spirit and Salvation - The Holy Spirit's Ministry In Us - The Holy Spirit's Ministry Through Us - The Baptism in the Holy Spirit
Learn something new every day More Info... by email Pruritus vulvae is the medical term for a persistent, uncomfortable itch on and around the vulva. It is a very common problem among women of all ages, and most cases are caused by irritation from clothing, sweat, or mild allergic reactions to soaps or hygiene products. In some instances, however, pruritus vulvae can be a sign of a more serious underlying condition, such as a sexually transmitted disease or a yeast infection. Home remedies and over-the-counter products are usually successful at treating minor pruritus vulvae symptoms. An itch that persists for more than a few days or becomes distressing enough to affect daily life needs to be addressed by a doctor. Many factors can contribute to pruritus vulvae, including poor hygiene practices, using scented soaps or cleansers, and wearing tight underwear made from synthetic materials. A woman may also experience an allergic reaction to a particular feminine hygiene product, clothing detergent, or contraceptive that causes redness and itching around the vagina. Bacterial and fungal infections are not as common, but they can represent potentially serious health problems when they occur. In most cases, frequent or constant itching is the only symptom of pruritus vulvae. The skin may appear redder than usual or develop a bumpy rash due to inflammation. If an underlying infection is present, there may be swelling in the area and a white or yellow foamy discharge from the vagina. Urination and sexual intercourse might be painful, and the condition can make it difficult to rest comfortably at night. Many women find that their symptoms tend to worsen when they are under a lot of stress. Relatively mild instances of pruritus vulvae tend to respond well to home treatments. A woman can usually relieve itching by washing her vulva twice daily with warm water and avoiding chemical irritants such as soaps and perfumes. It is helpful to wear loose-fitting cotton underwear to reduce friction and prevent excessive sweating in the genital region. If itching persists, an over-the-counter unscented moisturizer or anti-inflammatory cream may help. Doctors strongly discourage women from scratching, as doing so can cause further irritation and leave the skin more susceptible to bacterial infections. Women who experience lasting symptoms should schedule appointments with their gynecologists. A doctor can physically inspect the vulva and ask about symptoms to make a basic diagnosis. He or she might decide to test blood, urine, or skin samples to screen for different types of underlying infections. In addition to encouraging home care techniques, the doctor may prescribe a high-strength antibacterial or antifungal medication to use for about two weeks. With treatment and follow-up preventive care, most cases of pruritus vulvae can be cured.
Construct the likelihood with asymmetric uncertainties I want to study the correlation between 2 parameters, this is done by fitting a straight line. I have uncertainties on both parameters. I want to solve my problem using the Bayesian approach, i.e. I construct my likelihood, assume some prior information on the slope and $y$-intercept, and then I will get my posterior distribution. Then I would sample from my posterior distribution using MCMC. The first step would be to construct my likelihood: Assume the data come from a line of equation $y = mx + b$. Then the likelihood would be: $$P(D\|\theta, I) = \frac{1}{\sqrt{2\pi \sigma^2}} \exp(-\frac{(y - mx - b)^2}{2\sigma^2})$$ However, in my case the uncertainties are asymmetric, how can I construct my likelihood? For example, my data look something like this: $x^{\sigma +}_{\sigma -}$ and $y^{\sigma +}_{\sigma -}$ One way to solve this out is to calculate the average of the lower and upper uncertainties, so that: $$\sigma = \frac{\sigma^+ + \sigma^-}{2}$$ Now I have symmetric uncertainties, and then I will be able to construct my likelihood. Is there another method to solve this out? • You need to choose a distribution that models your measurement errors. Gaussian obviously can't capture the asymmetry. Can you put your measurement error data plotted so that we can recommend a likelihood? Apr 12, 2015 at 14:59 • @Memming, my data do NOT come from repetition of measurements. My data resembles properties of exoplanets. So, for example let's assume I have 10 different planets, each data point refers to the mass of the exoplanets. Example: mass of planet 1 = $3^{+1}_{-0.25}$. I am assuming that the errors are drawn from a normal distribution with mean 0 and variance $\sigma^+$ and $\sigma^-$. Apr 12, 2015 at 15:07 • I see. You could cut two Gaussians in half, and stitch together to make a frankenstein distribution in that case. Apr 12, 2015 at 15:20 • @Memming Can you give me please more details or references, this is the first time I come across cutting 2 gaussians in half! Thanks a lot :) Apr 12, 2015 at 15:23 You could cut two Gaussians in half, and stitch together to make a split normal distribution of your noise $\epsilon$: $$P(\epsilon) = N(\epsilon; 0, \sigma^+)I(\epsilon > 0) + N(\epsilon; 0, \sigma^-)I(\epsilon < 0)$$ where $I$ is the indicator function. Below is an example probability density function.
[purchase_link id=”4521″ text=”Add to Cart” style=”button” color=”blue”] The height comparison tool works for a wide variety of people and objects. For example, you can compare celebrity heights. Other height comparisons include presidents, nationalities, hominids, fictional characters, athletes, animals, buildings, vehicles, and even celestial objects. The height comparison tool can also do custom height comparisons where you input height measurements and perhaps even a custom image. Press the ‘Next’ button to see another random height comparison. Otherwise, use the forms labeled ‘Left’ and ‘Right’ below to setup your own height comparison. Choose a category and subject to compare and then press the update button. Don’t forget to share your height comparison by using the copy to clipboard button and pasting it on social media or anywhere on the web. See below for more information on the height comparison tool. Units: imperial metric Using the Height Comparison Tool The height comparison tool can be used in the basic way explained above. It can also be used to do custom comparisons. For example, if you want to compare your own height with, say, Robert Wadlow, you can do so as follows: Set Robert Wadlow for one side, and then for the other side select the category ‘Average Person’ and then select either average male or female. Next input your height. If you want to get a bit more advanced, you can take a picture of yourself, crop it so that there is no space above or below your body (you can do this with Microsoft Paint or Word), and then upload it to a file sharing service such as Drop Box. Next, get the url for the image and paste it in the Image url text box. You might have noticed the adjustment field. This is to account for such things as footwear, like high heels, and slouching. It is typically set at 1” as that is the approximate thickness of most shoes. But for celebrity height comparisons where women often have high heels, the adjustment can be changed to, say, 4”. To see an example of this, consider the Jennefer Aniston height comparison with Zeng Jinlian, the tallest women on record to have lived. While Jennifer Aniston is wearing what look to be about 4″ heels, Zeng Jinlian is hunched over with her scoliosis and so is given a -4″ adjustment. The adjustment field can also be used for other objects such as, say, a flag pole or antennae on a skyscraper. The height comparison tool can also compare lengths as follows: If the width of an image is much greater than the height, the length data is also provided in the output. The length data is secondary as it is dependant on the image proportions, and thus may not be as accurate. That being said, subjects like the Titanic and Blue Whale were added with correct length as the priority. To achieve this for a custom image, set the height to the true length multiplied by the image height in pixels over the image width in pixels. Units for Height Comparisons You can select between metric and imperial. The input is then either cm or inches and feet. The output automatically changes to larger units such as m, km, and miles as larger objects are compared. The Height Comparison Scaling Exponent You may have noticed the scaling exponent field. This is the power to which height scales with mass by, and thereby volume too. Other height comparison tools assume a cubic relationship, where proportions are maintained as people get larger. This is in contrast to the Body Mass Index, which assumes a square relationship. In actuality, humans scale somewhere between cube and square, somewhere around 2.5. That’s why this is the default scaling exponent. The scaling exponent only comes into play when doing height comparisons that use the default male and female silhouettes. This is because these, unlike the specific images, must scale to a variety of sizes. With a scaling exponent of 2.5, people get a bit narrower as they get taller. If you increase this number, this will be diminished and vice versa. Origin of the Height Comparison Tool The height comparison tool was originally built to give people an appreciation for tall people and height differences. This explains the presence of Robert Wadlow, Zeng Jinlian, and Yao Ming. The project grew from there to look at tall outside of humans and that’s where Chewbaka, the Saturn V rocket, and the Burg Khalafi came in. Going forward, the plan is to include anything noteworthy for height, whether tall or short, as well as interesting for comparisons sake. This includes ancient hominids, presidents, athletes, celebrities, fictional characters, and inanimate objects. Who wouldn’t want to see what Lebron James looks like next to Bigfoot? Perhaps you feel like contributing to the height comparison project. The simplest way is to gather some height data, preferably in metric, and send it to [email protected]. If you have time, images would be helpful too. Please remove the backgrounds and crop to fit the subject. There are many programs you can do this with, Microsoft Word being just one. If you do provide images, please make sure they can be shared for free, such as with a Creative Commons license (Flickr and Wikicommons are good places to look), and please include the attribution link or html code. So what do you think of the height comparison tool? Do you have any suggestions? Please share your comparisons by using the copy to clipboard button and posting it to social media or anywhere on the web.
Container Closure Integrity Testing is performed to evaluate the adequacy of a closure in maintaining a sterile barrier. Of primary concern is whether the container can provide an effective barrier against ingress of microorganisms and other substances that may compromise or contaminate the product. In the past, sterility testing was performed to demonstrate container integrity; however, due to the insensitivity and other complications associated with sterility tests, a variety of container and closure integrity tests were developed. While no strict standard exists for all integrity test methods, the Parenteral Drug Association (PDA) Technical Report (TR) 27 and FDA guidance on the subject does have recommendations for integrity test performance. It is recommended that container closure integrity testing during initial packaging validations incorporate both physical and microbial challenge tests. Nelson Labs offers a variety of methods to evaluate container closure integrity. The microbial challenge test is performed as a direct evaluation of the container and closures ability to prevent microbial ingress. All sterile pharmaceutical containers must not allow organisms into the container which would contaminate the product. A commonly accepted microbial challenge method is integrity testing via microbial immersion. The PDA TR 27 encourages that the challenge should simulate worst-case production and shipment conditions. At Nelson Labs we have a unique challenge apparatus, which allows testing to be performed under a variety of both negative (vacuum) and positive pressures. This allows simulation of all types of production and shipment methods, including air freight. Many manufacturers are not sure when or how often they should conduct Container Closure Integrity, but the testing is extremely important to ensure the product will remain sterile in the package configuration for the shelf life of the product. Container Closure Integrity Testing should be conducted during the initial packaging validation. Additionally, as detailed in the FDA Guidance document on the subject, testing should be performed as part of the stability protocol in lieu of Sterility Testing. Testing should be conducted annually on production lots to monitor for any changes in the process and/or materials.
Large inguinal bladder hernias: can a preoperative diagnosis be made? ConclusionThe main objectives in treatment of inguinal bladder hernia are to preserve the voiding function and to avoid bladder injuries in a tension-free hernia repair. To our knowledge, this is the first series of cases in which all inguinal bladder hernias were diagnosed preoperatively. CONCLUSIONS: Ovarian inguinal hernias should be considered among the differential diagnoses of a groin mass or swelling. In women of reproductive age, repair of the hernia with the intent to preserve fertility is of critical importance. PMID: 31696731 [PubMed - as supplied by publisher] Conclusion: A combination of laparoscopic reduction and nonsutured PEG gastropexy is a safe and effective alternative treatment for high-risk patients (with significant morbidity and mortality) with symptomatic PHs. Most patients (80%) returned to normal oral intake postprocedure and were discharged home within 3 d. PMID: 31624456 [PubMed - in process] ConclusionAs PDH can lead to major and life threatening complications, it must remain in our minds as a possible cause of intestinal obstruction. Abstract Lumbar hernias are from weakened areas in the posterior lateral abdominal wall. Minimally invasive techniques are recommended for nonmidline abdominal wall hernias. Endoscopic methods utilizing the subcutaneous space only are rarely reported. A 66-year-old man presented with abdominal pain and a computed tomography (CT) scan revealing a lumbar hernia. The procedure was done utilizing the subcutaneous space to open the hernia sac and repair the defect in layers. A sublay mesh and an onlay mesh were used within the subcutaneous pocket. The patient had an uneventful postoperative course and was discharged ho... We present a case of a 60-year-old male patient presented with bilateral inguinal swelling associated with urinary hesitancy and intermittency. He had undergone transabdominal preperitoneal (TAPP) repair for a left inguinal hernia 8 years ago. CT scan confirmed the presence of a bilateral hernia with the bladder herniating bilaterally. He underwent an elective bilateral open Lichtenstein tension-free mesh repair. AbstractForamen of Winslow hernia (FWH) is an extremely rare entity accounting for up to 8% of internal hernias and 0.08% of all hernias. Only 150 cases of FWH have been described in the literature to date with a peak incidence between the third and sixth decades of life. Three main mechanisms seem to be implicated in the FWH pathogenesis: (a) excessive viscera mobility, (b) abnormal enlargement of the foramen of Winslow, and (c) changes in the intra-abdominal pressure. The presence of an abnormally long bowel, enlargement of the right liver lobe or cholecystectomy, a “wandering cecum,” and defects of the gastr... Publication date: Available online 19 July 2019Source: International Journal of Surgery Case ReportsAuthor(s): Dario Iadicola, Massimo Branca, Massimo Lupo, Eugenia Maria Grutta, Stefano Mandalà, Gianfranco Cocorullo, Antonino MirabellaAbstractIntroductionTraumatic diaphragmatic injuries are rare complications resulting from a thoracic-abdominal blunt or penetrating trauma. Left-sided diaphragmatic injuries are more commonly reported in literature. Bilateral injuries are extremely rare, occurring in about 3% of the patients and just few cases reported in literature. Traumatic diaphragmatic hernias are definitely a m... ConclusionThe introduction of a liquid material which solidifies after injection in a short time (hydrogel) using a needle is feasible. The combined CT-scan and US image guidance allows for the percutaneous placement of the needle in the required location. The introduced hydrogel remains in this space, corresponding to the inguinal region, without moving. The placed hydrogel compresses the posterior wall composed of the transversalis fascia, supporting the potential use of hydrogel for hernia defects. ConclusionThe clinicians should consider this rare condition in the differential diagnosis of patients presenting with large paraumbilical hernias associated with classical symptoms of acute pancreatitis, particularly in the absence of typical risk factors for pancreatitis. An intravenous contrast-enhanced abdominal CT scan should be performed immediately in these patients. We recommend the patients and the surgeons to consider prompt surgical repair for paraumbilical hernias to avoid further complications and the higher incidence of morbidity and mortality associated with emergency surgeries. ConclusionGradual postoperative closure of a traumatic abdominal wall hernia with an ostomy in place may result in stomal stenosis. Stomal patency must be carefully evaluated during this process.
Below 300 (inshore waters) in British waters A bottlenose dolphin may be black, brown or dark grey on its back, with lighter flanks. They have a tall, sickle-shaped dorsal fin and pointed flippers. Bottlenose dolphins are highly social, intelligent animals, and individuals often co-operate in activities such as hunting, baby-sitting and defence against predators. They are most often found in small groups (of two to 50 animals), and alliances and relationships between individuals are complex. They are capable of problem solving and tool-use, and are inquisitive and playful, frequently seen riding the bow waves of ships and large whales. Length: 3.2 – 3.6m (males are slightly larger than females on average) Weight: Up to 650kg Lifespan: 40 – 45 years (males); up to 50 years (females) Mating occurs throughout the year but in British waters most births are between May and November. A single calf is born after a gestation of about 12 months and is dependent on milk for 18 to 20 months. It may continue to suck for several years while swimming, hunting and social skills are developed. Fish (including haddock, hake, trout, bass and sandeels), cephalopods and crustaceans. Inshore areas include estuaries and harbours, with brief forays into fresh water. Bottlenose dolphin are also found in more offshore waters. Killer whale and shark predation is less common in British waters than elsewhere. Boat strikes and entanglement in fishing gear, pollution and depletion of fish stocks. Status & conservation Native. It is a UKBAP priority species and is legally protected in British, Irish and European waters. Habitats in the Moray Firth in Scotland and Cardigan Bay in Wales are designated as Special Areas of Conservation under the EU Habitats Directive. UK population size & distribution Several hundred are resident in British waters. Resident populations in the Moray Firth and Cardigan Bay, and commonly spotted off the coast of southern Ireland and southwest England. Two semi-resident groups are found off the UK coast, in Cardigan Bay and the Moray Firth, which have both been designated SACs. Elsewhere, there are smaller groups off south Dorset, around Cornwall and in the Sound of Barra, Outer Hebrides. Did you know? Females sometimes act as midwives, helping during births by supporting the mother in the water or by pushing the calf up to the surface to breathe. One individual was observed biting through the umbilical cord.
Raph Koster introduces himself as an alien from another planet: a game designer. He's the author of The Theory of Fun. He starts by introducing structure in music and art with some cool audience participation. There are different dimensions to fun: Hard fun is about solving problems. The problems tend to be mathematical Therefore the grammar of hard games ignore presentation. He applies the theory of fun to Amazon.com and concludes that it's not structural, not fun. There a lots of sequential steps and don't provide any "fun" or feedback. The magic ingredients: - Territory - where you meet the challenge matters. Doing the same thing in different places should make a difference. The topology should affect the available options. - Preparation - when you buy it, what pages and interactions you saw should matter. Everything you did before should matter. The last interaction you had should matter (think of your opponents last move). Never start an interaction with no context. You must prepare for the encounter. - How - should involve skill on your part (eBay is more fun than Amazon). The core verb should be repeatable. Tricks and tips should matter. You should feel like you're growing more competent. Competition is an important element and people need to be able to see it. - What - buying different things should feel different. The same verb must be applicable in many different challenges. A given verb is a hammer. You should present them with lots of nails. - With - what tools you use should matter. Give users an array of tools to solve the problem. The system should give the user different rewards of different feedback based on how the challenge was met. - For? - you need feedback. A game that has only one possible outcome is boring. A lot of services drive you toward a given outcome and then they stop. Usually, the best feedback is a grater challenge. Sometimes it's a pleasant surprise. Either way it has to be highly visible. - Few? - don't always get what you want. Low risk activity for high reward is bad for fun. You need to drive users to challenges at the edge of their ability. - Phooey - fun comes from learning. Failure is important to learning. Making a wrong choice has to be a set back. Fun won't exist if there's no consequence. All of this can be quantified. You can give people ratings for how hard it is to accomplish a particular task. What is the challenge rating for buying a particular book at Amazon?
# Points A(3, 1), B(5, 1), C(a, b) and D(4, 3) are vertices of a parallelogram ABCD. Find the values of a and b. - Mathematics Sum Points A(3, 1), B(5, 1), C(a, b) and D(4, 3) are vertices of a parallelogram ABCD. Find the values of a and b. #### Solution The given points of the parallelogram are A(3, 1), B(5, 1), C(a, b) and D(4, 3). We know that the diagonals of a parallelogram bisect each other. So, O is the midpoint of AC and DB. So, ((3+"a")/2 ,(1+"b")/2) =((5+4)/2, (1+3)/2) ⇒ ((3+"a")/2 ,(1+"b")/2) = (9/2,4/2) ⇒ ((3+"a")/2 ,(1+"b")/2) = (9/2,2) On comparing we get (3+"a")/2 =9/2 ⇒ 3 + a = 9 ⇒ a = 6 Also, (1+"b")/2 = 2 ⇒ 1 +b = 4 ⇒ b = 3 Thus , a = 6, b = 3 Concept: Similarity of Triangles Is there an error in this question or solution?
- Cooking Time: - Preparation Time: - 1 tablespoon of oil - 2 tablespoons of butter - 1 tablespoon of grated lemon rind - 2 tablespoons of lemon juice - 2 tablespoons of fresh oregano leaves - 4 beef steaks, thick - black pepper - lemon slices or wedges for garnishing - Put oil and butter in a pan over medium heat. Add the lemon rind, lemon juice and oregano and sauté for 3-4 minutes. - Remove mixture from pan. - Increase temperature to hot. - Sprinkle steaks with pepper and cook in pan; cook each side for 3-4 minutes. - Arrange beef on a serving platter, sprinkle with lemon and oregano mixture. - Serve with fresh beans and pour the pan juices all over. - Garnish with lemon
When kids have trouble communicating If your child has language troubles, you’re not alone. Around three to five per cent of children experience difficulties in this area. The great news is that most language issues can be overcome or minimised with the right speech-language therapy. A child with language difficulties may have trouble understanding written and spoken language or gestures (known as receptive language), or find it hard to express themselves through the spoken or written word (known as expressive language). You might notice your child has trouble listening or following instructions. They might not have many words or speak infrequently, become frustrated because they can’t express themselves, give unusual answers to questions, or struggle to form clear written or spoken sentences. Below are the two main types of language difficulties for children, and what to expect from both. Receptive language Receptive language is the ability to understand words and signals. Children with receptive language issues may have trouble understanding what is being said or asked of them. Some children with receptive language difficulties become adept at picking up on key words or gestures. When this happens, it may appear like they understand what is being communicated when in fact they are using clues to guess and respond. Depending on their age, children with receptive language difficulties might: Struggle to understand and follow instructions Appear like they aren’t paying attention Repeat a question instead of providing an answer Give an unusual answer, as though they haven’t understood the question Have trouble concentrating on what’s being said Withdraw and avoid certain tasks and activities Expressive language Expressive language is the ability to communicate using words, facial expressions and gestures. Children with expressive language issues can usually form words, but have trouble understanding how words and sentences fit together to form meaning. Depending on their age, children with expressing language difficulties might: Have difficulty finding the right words to express themselves Not be talking Use shorter words and sentences compared to children of a similar age Frequently use the wrong words or leave out words in sentences (they might say “I going” instead of “I am going”) Have difficulty answering your questions Have difficulty telling you what they have been doing or retelling a story Often rely on using familiar phrases when speaking with others Remember, children develop language skills at different rates. Sometimes, they simply need a little extra help to catch up with their peers. Our Speech Pathology team can provide assessment and support for your family. Contact us for more information.
* All date and time are in GMT (UTC) time. User Activity Analysis With iPracticeMath, you are able to keep track of your tests, worksheets and other activities, and also gauge your own performance. - Generate a detailed report of all the tests attempted . - See how many questions you answered correctly - Find your accuracy rate for each topic and subtopic. - View total number of questions between specific dates or in a given time period. - Know your strong and weak areas in math. - See detail report for each subtopic. Please sign in to see your students performance analysis reports. Become a Member. Enjoy great benefits! - Track progress in real-time - Easy access to specialized user reports - View progress history - Get notified when new topics are added - Quiz and additional worksheets (coming soon) - Special certificates for registered users Register as teacher
टाटा संस के चेयरमैन बनाए जाएं, उन्हें हटाना गलत था। हालांकि, न्यायाधिकरण ने कहा कि बहाली आदेश चार सप्ताह बाद अमल में आएगा। टाटा संस को अपील करने के लिए यह समय दिया गया है। बता दें कि एनसीएलटी में केस हारने के बाद मिस्त्री अपीलेट ट्रिब्यूनल पहुंचे थे। एनसीएलटी ने नौ जुलाई, 2018 के फैसले में कहा था कि टाटा संस का बोर्ड सायरस मिस्त्री को चेयरमैन पद से हटाने के लिए सक्षम था। मिस्त्री को इसलिए हटाया गया, क्योंकि कंपनी बोर्ड और बड़े शेयरधारकों को उन पर भरोसा नहीं रहा था। अपीलेट ट्रिब्यूनल ने जुलाई में फैसला सुरक्षित रखा था। बता दें कि अक्तूबर 2016 में सायरस मिस्त्री टाटा संस के चेयरमैन पद से हटाए गए थे। दो महीने बाद मिस्त्री की ओर से सायरस इन्वेस्टमेंट प्राइवेट लिमिटेड और स्टर्लिंग इन्वेस्टमेंट कॉर्प ने टाटा संस के फैसले को एनसीएलटी की मुंबई बैंच में चुनौती दी थी। कंपनियों की दलील थी कि मिस्त्री को हटाने का फैसला कंपनीज एक्ट के नियमों के मुताबिक नहीं था। जुलाई 2018 में एनसीएलटी ने उनके दावे को खारिज कर दिया। बाद में सायरस मिस्त्री ने खुद एनसीएलटी के फैसले के खिलाफ अपील की थी। पुलिस का कहना है कि किशोरी लगातार बयान बदल</s>
पिताजी जोर से चिल्लाते हैं । प्रिंस दौड़कर आता है पूछता है क्या बात है पिताजी? प्रिंस लेकिन मेरी गाड़ी तो मेरा दोस्त ले गया है सुबह हीऔर आपकी गाड़ी भी ड्राइवर ये कहके ले गया की गाड़ी की ब्रेक चेक करवानी है। पिताजी ठीक है तो तू स्टेशन तो जा किसी की गाड़ी या किराया की करके? उसे बहुत खुशी मिलेगी। पिताजी तूझे शर्म नहीं आती ऐसा बोलते हुए ? घर में दो-दो गाड़ियां होते हुए भी घर की बेटी किसी टैक्सी या आटो से आयेगी ? क्या उसे हम सबका प्यार पाने का हक नहीं ? तेरा जितना अधिकार है इस घर में उतना ही तेरी बहन का भी है। कोई भी बेटी या बहन मायके छोड़ने के बाद वह पराई नहीं होती। मम्मी आप कुछ शरम तो कीजिये ऐसे जवान बेटे पर हाथ नहीं उठाते। पिताजी तुमने सुना नहीं इसने क्या कहा? अपनी बहन को पराया कहता है .ये वही बहन है जो इससे एक पल भी जुदा नहीं होती थी हर पल इसका ख्याल रखती थी। पाकेट मनी से भी बचाकर इसके लिए कुछ न कुछ खरीद देती थी। बिदाई के वक्त भी हमसे ज्यादा अपने भाई से गले लगकर रोई थी। और ये आज उसी बहन को पराया कहता है। प्रिंस -(मुस्कुराके) बुआ का भी तो आज ही जन्मदिन है पापा वह कई बार इस घर में आई है मगर हर बार आटो से आई हैआप कभी भी अपनी गाड़ी लेकर उन्हें लेने नहीं गयेमाना वह आज तंगी में है मगर कल वह भी बहुत अमीर थी आपकी और इस घर की उन्होंने दिल खोलकर सहायता और सहयोग किया है। बुआ भी इसी घर से बिदा हुई थी फिर रश्मि दी और बुआ में फर्क कैसा। रश्मि मेरी बहन है तो बुआ भी तो आपकी बहन है। कि तभी बाहर गाड़ी रूकने की आवाज आती है.तब तक पापा प्रिंस की बातों से पश्चाताप की आग में जलकर रोने लगे और इधर रश्मि भी दौड़कर पापा-मम्मी से गले मिलती है.. लेकिन उनकी हालत देखकर पूछती है कि क्या हुआ पापा? पापा तेरा भाई आज मेरा भी पापा बन गया है। रश्मि भाई की तरफ देखते हुए ऐ पागलनई गाड़ी न? बहुत ही अच्छी है मैंने ड्राइवर को पीछे बिठाकर खुद चलाके आई हूँ और कलर भी मेरी पसंद का है। प्रिंस हैप्पी बीर्थदय तो यू दीवह गाड़ी आपकी है और हमारी तरफ से आपको बीर्थदय गिफ्ट बहन सुनते ही खुशी से उछल पड़ती है की तभी बुआ भी अंदर आती है। बेटी और बहन दो बेहद अनमोल शब्द हैं जिनकी उम्र बहुत कम होती है। क्योंकि शादी के बाद एक बेटी और बहन किसी की पत्नी तो किसी की भाभी और किसी की बहू बनकर रह जाती है। शायद लड़कियाँ इसलिए मायके आती होंगी कि उन्हें फिर से बेटी और बहन शब्द सुनने को बहुत मन करता होगा ।
Graham, sharing his first post, has overcome his fear of bullying. Click to see Grahams post from 6/16/19 on @SoulEssenceChild Instagram. He has gained his inner strength through his energetic development and cannot be controlled by bullies. Afterall, when you understand it, the core of bullying is about energetic control of another person. Bullies use their sensing out of their fear of lack of control to fuel their bullying. Bullies, in their core of being, do not feel safe in the world. So, behind every bully is someone who is exercising control over them. They then move into the world looking to find a way to energetically control someone else, using bullying as a mechanism of control. Children who possess energetic boundaries are not affected by the energetic control of the bully. In a child’s energetic development Stage 01, Soul Self Entry is about gaining that internal control over self. Children listen to one voice file at night or in the morning for 30 days. It takes them through the labyrinth that has kept their soul from finding a way to be fully here on Earth. Being fully here brings them the internal control of self and therefore no matter how someone bullies them, the bully cannot control them. The children experience the safety of their internal self. The mechanisms of this have eluded humans until now – all can have energetic development. Purchase Soul Self Entry for your child. The voice files are appropriate for any human 6 years or older.
Many people live life unaware that they have hidden anger – suppressed anger that only occasionally surfaces. While this hidden anger is usually rooted in past childhood hurts, the underlying effects are always ready to surface on the scene. For example, when someone says or does something wrong, the one with suppressed anger often overreacts. When someone makes an innocent mistake, the magnitude of anger is out of proportion to the mistake. If you have hidden anger, you can find yourself at one extreme or another – from feeling hopeless to feeling hostile – and yet be totally unaware of why you are experiencing these feelings. The Bible makes it clear that some of our motives and emotions are hidden from our own view. Psalm 19:12 “Who can discern his errors? Forgive my hidden faults.” The hidden anger cues are: - Irritability over trivialities. - You smile on the outside, while you hurt on the inside. - You find your identity and worth in excessive work. - You deny ever being impatient. - You have to have the last word. - Those close to you say that you blame others. - You feel emotionally flat. - You find yourself quickly fatigued. - You have a loss of interest in life. - You become easily frustrated. When you discover that you might have hidden anger in your life, follow the counsel of Colossians 3:8 “You must rid yourselves of all such things as these: anger, rage, malice, slander, and filthy language from your lips.”
We are spending almost one fourth or one third of our life being schooled. What is the real purpose of school? To acquire knowledge/information? To be trained for jobs? To be a good person to society? Different people have different answers. Seth Godin gave several points in his video. One of his points on connecting dots emphasize on thinking instead of memorizing. Students need to be taught how to think and how to solve problems, not what to think and what to memorize. Once they learn the techniques of connecting dots, they will still be able to connect dots although the dots may change. Seth thinks there is no value to memorizing things. But I think memory work is necessary for learning. When students begin to learn a subject, they should first memorize facts, then understand and apply these facts into a creative process. If students are only tested about how much/how well they memorized (my school experience before I went to university), they will lose their interests. Before I went to university, I was taught to memorize things and I was tested about how well I memorized. In order to get a high score and be accepted by a good school, I need to focus on memory works. I often forgot the content after I turned in my tests. I didn’t know much about how to think. This is the wrong direction for education. Critical pedagogy suggests that teaching and learning should be contextual and aim at raising critical awareness among students. Critical pedagogy has been used by educators to refer to a broad range of pedagogies that employ critical theory, feminist theory, anti-racist theory, multicultural education, inclusive pedagogies, and so on. Geographic information systems (GIS) is an useful tool of critical pedagogy becasue it has the potential to help reproduce or transform oppressive conditions in society and it can be used to examine and build contexts that maximize students’ ability to analytically observe, consider, and respond to the world in which they live (Crampton and Krygier’s “An Introduction to Critical Cartography”). Below are two examples to illustrate how GIS can be used for critical educators to engage students in critical thinking. Veronica Velez, Daniel Solórzano, and Denise Pacheco explore the role of race and racism in shaping the historic, evolving spatial relationship between south Los Angeles high schools near the Alameda “Corridor,” and their surrounding communities. They apply GIS within a critical race methodology to examine geographic and social spaces, identify and challenge racism within these spaces as part of a larger goal of identifying and challenging all forms of subordination. They spatially examines how structural and institutional factors influence and shape racial dynamics and the power associated with those dynamics over time. Matthew W. Wilson’s Critical & Social Cartography seminar in Harvard Graduate School of Design asked students to think and make pretty maps by their analytical skills. In order to make pretty maps to reflect reality, what information should be included or excluded? How to represent different variables or types of information? How might a map designed to meet the needs? What would the students be required to do in order to create this map? Through the process of problem-posing, students were encoraged to think critically. Merging GIS and critical pedagogy requires that we ask how GIS can help students theorize from multiple perspectives about the role that space and spatial relationships play in their immediate lives, local communities, and beyond. As a widely applied tool, GIS can be applied to critical pedagogy. It is very inspiring to learn from this week’s reading materials that games (i.e., video games and role playing games) can contribute to student learning. Games are not only designed for fun. They can motivate and actively engage learners in the learning processs, and kills utilized in games can be translated to the real world. Thus, Game-Based learning and gamification get a lot of attention and are fast becoming used in the classroom (see more information about Game-Based learning from Jessica Trybus’s paper “Game-Based Learning: What it is, Why it Works, and Where it’s Going“). It seems like bringing games to the classroom might be an acceptable, even accredited, alternative strategy to education. I would also like to share an interesting TED talk by Jane McGonigal: Gaming can make a better world. According to McGonigal, if we can create engaging and fun games based on meaningful real world problems, we can leverage the combined knowledge, energy and enthusiasm to solve the world’s biggest problems and we can change the world. In the “Making the Grade: The Role of Assessment in Authentic Learning”, Marilyn Lombardi compared authentic assessment with traditional assessment. According to the information provided in Table 1, traditional assessments seem to have few positive characteristics. Thus, a movement from traditional assessment to authentic assessment improves teaching and learning (see more from Grant Wiggins’s “A True Test: Toward More Authentic and Equitable Assessment” and “The Case for Authentic Assessment“). From my experience, some mix of the two seem to be more appropriate and beneficial. As an instructor of an introductory Remote Sensing course, I applied traditional assessment tools (multiple-choice quizzes, short-answer exams, and essays) and authentic assessment (hands-on experiments, computer labs, and class projects). The combination of the two improves teaching and learning. Quizzes, which only have five multiple choice questions covering basic concepts and key ideas of a former lecture each time, help me measure students’ acquisition of knowledge and my teaching quality. When students made mistakes, they didn’t acquire the knowledge because of their misunderstanding or my unclear explanation. Then I can find another way to explain the concept clearly. The relationship between the time used to answer each question and accuracy of the question can reflect students’ learning in some way —shorter time with higher accuracy means students are likely acquire the knowledge, longer time with lower or even higher accuracy means students are not familiar with the knowledge, and shorter tiem with lower accuracy means students do not care. Hands-on experiments and computer labs, which are designed to introduce various useful equipments, software, and skills, help students apply the knowledge to solve real-world problems. Then students developed their own class projects related to their interests and I talked more about the topics they focused but not well covered in former classes. Authentic assessment complements traditional assessment but it increases my workload. My advisor is always trying to find a better way to mix the two for a large class. According to National Council for Excellence in Critical Thinking, critical thinking is “the intellectually disciplined process of actively and skillfully conceptualizing, applying, analyzing, synthesizing, and/or evaluating information gathered from, or generated by, observation, experience, reflection, reasoning, or communication, as a guide to belief and action.” Everyone endorses the teaching of critical thinking and every teacher try to build their teaching philosophy. But critical thinking taught in what fashion? And how to evaluate teaching effectiveness for critical thinking? In the field of Geography, there is a growing need for software training, especially for GIS and remote sensing. I think the best way to learn software is a question-driven approach or a project-oriented approach. Most of GIS and remote sensing courses use computer labs and customized class projects to help students to get familiar with software packages, and more importantly, to improve their skills in computer-aided problem-solving. Based on my experience as a teaching assistant and an instructor, two types of strategies are used mostly for computer labs. The first one is providing students with detailed step-by-step lab instructions. Students only need to follow the instructions and click the button even without thinking. There are less simple questions from students because they have all the information. But at the end of the courses, many students still know little about the software techniques. The second one is providing students with problems, goals and plenty of data. Students need to select their methods and data to support their analysis. It encourages students to think critically to solve the problems. Some students will find multiple ways to reach the goals and bring good ideas for their class projects, but many others, especially undergrads, still rely on instructors and teaching assistants to tell them step by step. They complain the second method is too hard and time consuming. They suggest instructors should provide step-by-step instructions from their evaluation. In such cases, evaluation is not effective. How to solve this mismatch problem? Blogging has become a popular and exciting activity in education. Teachers encourage students to write blogs or assignments, read and post comments on each others postings. It is a good way for communication and sharing ideas. Students will improve their writing and narrative skills with this activity. For seminar courses or courses in humanities and social science, blogging, instead of other traditional ways, may enhance students’ learning. However, for courses in natural science such as math or lab courses, I don’t think blogging is necessary or even useful. When teachers consider to use blogging for education purpose, they should think about the reason to use it, not just because it is popular and fancy. W. Gardner Campbell, Scott Rosenberg, Tim Hitchcock, Seth Godin and Tom Peters who only emphasize on the goodness of blogging are all from humanities and social science, I think people from natural science probably have different voices. Blogs are also used in middle and high school. Middle and high school blogging is like a web-based course site (blackboard, scholar, instructure canvas, etc) to provide information to students, parents, administration, or other teachers. Their blogs may include announcements, assignments, and discussion forum. Students can use blogs to discuss various topics and to interact with their teachers. Parents can use blogs to understand what is occurring in the class. The idea sounds great but I am not sure whether effective or not. Because the publicity of blogs may contain information from wrong points of view or extreme points of view which are harmful to young learners. In order to keep pace with the times, teachers should improve their teaching strategies with new technologies, but they need to be careful, especially for teachers of young learners.
KEY TECHNOLOGY AREA(S): Chemical/Biological Defense; Battlespace Environments; Sensors OBJECTIVE: Develop a Deep Learning (DL) threat detection solution using a fusion of imaging sensors and chemical/biological sensors to detect and locate concealed chemical threats (with potential capabilities for both biological and explosives threats). The developed architecture must be deployable on edge computing platforms for use in real time (better than 60 second detection, 60 frames per second for video sensors) standoff threat detection platforms (50 m) such as Unmanned Aerial Vehicles (UAVs) and Unmanned Ground Vehicles (UGVs). DESCRIPTION: Detection of concealed chemical threats through the development of sensor technology has improved over the last decade. Automated threat identification and location remains a challenge in operational environments. Multi-modal sensing promises to provide greater threat detection capability, as well as identification of threat location and type than individual sensing modalities can provide. Imaging solutions, such as infrared sensors, LIDAR, and RADAR, provide threat detection and location capabilities but cannot adequately differentiate chemical threat types. Chemical sensors provide remarkable capability of threat identification, and general vicinity detection but cannot adequately spatially locate chemical threats. A multi-modal approach to threat detection will provide improved situational awareness and inform appropriate threat response. DL algorithms have significantly improved the ability to autonomously detect a wide range of threats. Recent developments of DL algorithms combine audio and visual representations of a state to increase the correlation of input data to a specific target. Extrapolating from visual and auditory inputs to other sensing modalities will drive automated detection algorithms for chemical/biological threats for environmental awareness of operational environments. Development of a DL architecture that jointly exploits the signature from a chemical sensor with a threat signature from an imaging sensor has multiple benefits over single mode detection modalities by increasing threat detection confidence, as well as threat identification/classification. Additionally, multi-modal DL architectures have shown promise of being less vulnerable to adversarial examples, inputs modified by introducing small perturbations to deliberately fool a target model into outputting incorrect results, bringing an additional layer of security to Department of Defense (DoD) threat detection technologies. Phase I proposals should advance the state-of-the-art of automated chemical threat detection, location, and identification by incorporating multi-modal sensor inputs to a DL detection/identification process. To advance to a Phase II project, performers must demonstrate improved detection/identification rates higher than single mode detection techniques. It is expected that in Phase I and Phase II, performers will utilize Commercial-Off-the-Shelf (COTS) or novel sensor technologies. PHASE I: Develop and test a DL architecture that jointly exploits multi-modal sensor inputs for chemical threat detection and identification. Demonstrate the improved detection performance of the multi-modal DL architecture over single mode DL automated detection algorithms. During the Phase I project, the proof-of-concept demonstration should focus on the discrimination of at least two or more chemical threats with a clear path forward on implementing the DL architecture with low size, weight and power (SWaP) computing hardware for edge computing. Chemical warfare threats of all classes are of interested for threat detection and localization (better than 5 meter accuracy). Examples of chemical threats of interest include, but are not limited to, chlorine; tear gas/pepper spray; and nitrogen oxides. The Phase I deliverable should explain the algorithms tested, software concepts, hardware requirements, results of single mode and multimodal detection tests, and potential use cases and limitations identified within the Chemical and Biological Defense program. PHASE II: Phase II will focus on the development and testing of an embedded multi-modal DL algorithm on a field portable computational platform that can accept multiple sensor inputs. Design of the DL architecture will enable low SWaP requirements of the computation platform to enable ease of deployment to operational environments on small unmanned vehicles (UxV). Evaluation of the multi-modal DL chemical detection algorithms will be extended to multiple threat vectors and demonstrate improved threat detection and identification over single mode DL architectures. Laboratory based characterization and validation of the embedded DL algorithm will be required for a successful completion of Phase II. Technical demonstration and validation of the developed technology in operationally relevant environments will take place with government personnel. PHASE III: The expected Phase II end-product is a well-designed, deployable edge computing device with an embedded DL algorithm trained for detection of chemical threats that can be used on ground and aerial vehicles. Follow-on government and civilian activities are expected to be pursued by the offeror. Transition of the developed technology will require refined algorithm training and testing to optimize the threat detection capability for the chemical threats of concern, as well as extending the number of trained threats and modalities that can be identified. Edge case testing will also be explored and defined. PHASE III DUAL USE APPLICATIONS: Multi-modal target discrimination DL algorithms can support and enhance medical diagnostic applications for increased prognostic assurance. Additionally, leveraging multiple sensor inputs improves perception of a vehicle’s immediate environment. REFERENCES: 1. Zhang, Shiqing, et al. "Multimodal deep convolutional neural network for audio-visual emotion recognition." Proceedings of the 2016 ACM on International Conference on Multimedia Retrieval. 2016. 2. Alshemali, Basemah, and Jugal Kalita. "Improving the reliability of deep neural networks in NLP: A review." Knowledge-Based Systems 191 (2020): 105210. 3. Ortega, Juan DS, et al. "Multimodal fusion with deep neural networks for audio-video emotion recognition." arXiv preprint arXiv:1907.03196 (2019). 4. Le, Minh Hung, et al. "Automated diagnosis of prostate cancer in multi-parametric MRI based on multimodal convolutional neural networks." Physics in Medicine & Biology 62.16 (2017): 6497. 5. Giering, Michael, Vivek Venugopalan, and Kishore Reddy. "Multi-modal sensor registration for vehicle perception via deep neural networks." 2015 IEEE High Performance Extreme Computing Conference (HPEC). IEEE, 2015.
Novel rational drug design strategies with potential to revolutionize malaria chemotherapy. Muregi, F. W. Kirira, P. G. MetadataShow full item record Efforts to develop an effective malaria vaccine are yet to be successful and thus chemotherapy remains the mainstay of malaria control strategy. Plasmodium falciparum, the parasite that causes about 90% of all global malaria cases is increasingly becoming resistant to most antimalarial drugs in clinical use. This dire situation is aggravated by reports from Southeast Asia, of the parasite becoming resistant to the "magic bullet" artemisinins, the last line of defense in malaria chemotherapy. Drug development is a laborious and time consuming process, and thus antimalarial drug discovery approaches currently being deployed largely include optimization of therapy with available drugs--including combination therapy and developing analogues of the existing drugs. However, the latter strategy may be hampered by crossresistance, since agents that are closely related chemically may share similar mechanisms of action and/or targets. This may render new drugs ineffective even before they are brought to clinical use. Evaluation of drug-resistance reversers (chemosensitizers) against quinoline-based drugs such as chloroquine and mefloquine is another approach that is being explored. Recently, evaluation of new chemotherapeutic targets is gaining new impetus as knowledge of malaria parasite biology expands. Also, single but hybrid molecules with dual functionality and/or targets have been developed through rational drug design approach, termed as "covalent bitherapy". Since desperate times call for radical measures, this review aims to explore novel rational drug-design strategies potentially capable of revolutionizing malaria therapy. We thus explore malaria apoptosis machinery as a novel drug target, and also discuss the potential of hybrid molecules as well as prodrugs and double prodrugs in malaria chemotherapy.
Generally speaking, the nature of the work of journalists is similar to that of historians. Both collect facts, verify them and present news and insights that are based on the accumulated facts. That’s why newspapers are considered a great source of history. Sometimes an article penned by a journalist goes on to be considered a historical record of itself. However, there are some important differences between the two professions. The first is that journalists work in the present, while historians work in the past. Yet interestingly, both are capable of predicting the future. Another difference is that news journalists are required to record facts objectively, while historians often include their own points of view and analysis. This is the reason why history often presents us with varying accounts of the same event. The final difference is that historians have the benefit of hindsight to assist with their research, while journalists are limited to the information they are able to obtain under very tight time constraints. Historians are at greater liberty to include their opinions, whereas news journalists should avoid doing so at all costs. Therefore, when reading an article by a historian in a newspaper or magazine, be aware that some opinions may be being presented as facts.
In general, the most important advantage of investing in bonds is that they are relatively less risky than shares (stocks). In case of bankruptcy, a company must first repay bondholders and creditors and only then repay shareholders. Of course, this lower risk also has a disadvantage: the risk premium linked to bonds is lower, which causes their expected return to be lower than that of shares over the long term. This means that if a company does well, the returns you enjoy with bonds probably aren’t going to be as high as the returns from shares. Bonds pay a set interest rate, while the value of shares grows as the value of a company grows. There are two ways that you can achieve a return investing in bonds: This is the return that is obtained from the periodic interest payments. This is the return that is obtained when the market value of the bond increases. Reasons for this can be: Note: As discussed above, the price return also can be negative. For instance, if the credit risk increases or interest rates increase, the price return could be negative. Source: VanEck. The figure only considers the factors interest rates, price level and bond yields and does not take into account other criteria that could potentially negatively influence the bond price.
Electronic products include assembled PCBs, enclosures, and cable assemblies connecting their different parts. USB, Ethernet, CAN bus, and RF assemblies have cables and connectors. Many cables in a product are bound together to form harnesses. Harnesses are common in cars and industrial control systems. Power and signal cables are harnessed separately to avoid interference between them. From a cable assembly standpoint, as a designer, you need to choose the readily available components. This practice reduces preproduction and production lead times. It also provides insights between cost and performance trade-offs so that you could take quick PCB design-related decisions. Power cables typically have the cables and connectors or lugs as terminations. In power cables, the power and current ratings are important. And the wire gauge will depend on the current. For instance, 5 V is given at one end of the cable, which carries a current of 1 A and has a resistance of 1 ohm. The voltage drop across the cable will be 1 V. Therefore, at the other end, the voltage seen will be 5-1, equivalent to 4 V. This may not be acceptable in most applications; the power loss in the cable will be 1 W. To reduce the voltage drop and power loss, the cross-sectional area of the cable should be increased to reduce the resistance. The resistance of power cables should be typically in milliohms. An example of a communication cable is a USB cable. The parameters of a communication cable include the operating frequency, the cable impedance (typically either 50 or 90 ohms), types of shielding and whether the cable is twisted or untwisted, and types of connectors. What is a cable assembly? A cable assembly is a bunch of wires or cables grouped by a heavy-duty thermoplastic, thermoplastic rubber, or vinyl material sheath. Every cable assembly is shielded by a sheath material such as PVC, fluorocarbons, and elastomers to protect the operating environment. It also makes it more organized when in use. Cable assemblies typically have connectors at each end of the cable. What’s the purpose of a cable assembly? Cable assemblies are built to shield the interior wires or cables from heat, friction, moisture, abrasion, compression, etc. They are available in different shapes and sizes and designed based on the operating environment. Specifications for a cable assembly - Operating frequency: Operating frequency depends upon the cable size. A larger diameter cable will not support high frequencies but a small diameter cable will. - Current and voltage rating: The voltage and current ratings of a cable assembly indicate its operating range. - Voltage drop: A voltage drop occurs when the voltage at the end of a cable is lower than that at the beginning. It happens due to increased resistance in a circuit and can be reduced by increasing the diameter of a cable. - Insulation material: Insulation material surrounds the individual conductor wires. It aims to protect wires from mechanical stress and prevent shorts and dielectric breakdown from nearby electrical signals. - Insertion loss: It should be as low as possible because it indicates the ability to carry an RF signal efficiently. - American wire gauge (AWG): AWG is the US standard for measuring the diameter of electrical conductors. AWG gives the estimation of the current-carrying capacity of the wire. The higher the AWG, the thinner the wire will be. - Temperature rating: Temperature variations always affect the electrical performance of the cable assembly. High temperature increases the conductor resistivity leading to copper losses. Temperature changes also affect dielectric properties. That is why dielectric is usually the temperature-limiting factor (for Polyethylene, the temperature range is -65 ºC to +80 ºC and for PTFE, it is -75 ºC to +250 ºC). For extended applications above 150 ºC, solid Teflon cables are not recommended. - Flammability rating: Materials with good flammability values help to minimize the number of toxins released during short circuits. - Ingress protection (IP) rating: IP rating gives the acceptable measurement against obtrusion of solids and liquids into mechanical and electrical enclosures. A higher IP rating indicates better protection against water and other invasive elements. - Voltage standing wave ratio (VSWR): VSWR should be as low as possible. It indicates uniformity along the length of a cable, connection strength, and compensation in the connectors for transitions in the cable or connector interfaces. - Average power handling: It is related to the ability of the cable assembly to dissipate heat generated by resistive and dielectric losses. It is good to have high power handling. - Outgassing: It occurs when trapped gas is released in PCB. This is a matter of concern in outer space where low outgassing materials are required to maintain a clean environment. Selection parameters for a cable assembly - Cable type: When selecting a cable type, review your application’s requirements based on usage and environmental conditions (extreme or even hazardous). For instance, the cable type for an assembly in a military vehicle application will be different from the cable type required in a television studio. Likewise, consider the number of conductors needed and the wire gauges to support the system functionality. A cable can be of two types: signal-carrying and power cables. - Connector type: After selecting the cable, pick the connector type that works best for your application. Again, consider the environment and usage. Simplify this choice by communicating with a vendor who also assembles connectors and offers a variety of options from the top manufacturers. A connector distributor along with cable design and assembly capabilities is a good choice since they will provide a custom end-to-end solution that has been derived from years of experience. - Shielding: EMI caused by noise generated by nearby cables and electronics is responsible for disrupted connections. Communication should be intact even when equipment is handled roughly, and shielding provides that type of protection. Foil shielding offers EMI protection but tears easily, making it undesirable for extreme conditions. Braiding is another option. It is far more durable, allowing easy passage of the signal. - Overmold or cable clamp or heat shrink wrap: Overmold and cable clamps are used to secure connectors and cable junctions. They provide strain relief between the connectors and the cables. A cable clamp is a very basic option but heat shrink is the best. The heat shrink is applied over the connection area and is shrunk to provide a tight fit. It offers moderate strain relief protection and helps with moisture resistance. On the other hand, overmold is a lightweight and heavy-duty molded cover that provides the best strain relief. It is good to choose a vendor that performs overmolding in-house for the quickest turnaround time and quality. - Coupling mechanism: Threaded connectors offer a secure mated connection. Push-together connectors can be mated and unmated easily but generally aren’t as rugged as desired. Bayonet-style connectors ensure the proper alignment of the mating halves. - Quality: IPC-A-610, IPC/WHMA A-620 class 3, and UL certifications are essential. Follow the relevant certifications and standards concerning your region. - DFM: Lead times tend to change based on product availability, design complexity, and application requirements. Vendors with readily available components, custom design expertise, and specification-based assembly provide the fastest delivery. But along with quick delivery, choose a certified and trusted vendor. Quick design tips for a cable assembly Achieving strength and durability at the same time is an intense design challenge when working in a confined environment like a cable assembly. Issues could be inaccurate design, material incompatibility, connector mating, and many more. Some of the best design methods for cable assembly are listed below. - The wire bend radius should be as large as possible. Tight radiuses slow down the manufacturing process, inducing stress on the terminals inside the connectors, hence latent failures. - Always identify the UL style. It helps to figure out the wire flammability value. - Make room for dimensional tolerances. Specify all dimensions from the connector reference plane. - Always add plating (tin, silver, nickel) to the wire to avoid corrosion and oxidation. Plating is also suitable for high-frequency operations. - Avoid direct marking; use shrink tube markers or self-laminating labels. - Always specify the number of contacts. - Use screws to stick to the assembly. - A well-defined coupling mechanism is necessary. Every application comes with unique requirements, and a single cable assembly cannot fulfill all of them. Choose a vendor who will help you sail through these impactful decisions.
Neuroscientists in Bonn and Heidelberg have succeeded in providing new insights into how the brain works. Researchers at the DZNE and the German Cancer Research Center (DKFZ) analyzed tissue samples from mice to identify how two specific proteins, 'CKAMP44' and 'TARP Gamma-8', act upon the brain's memory center. These molecules, which have similar counterparts in humans, affect the connections between nerve cells and influence the transmission of nerve signals into the hippocampus, an area of the brain that plays a significant role in learning processes and the creation of memories. The results of the study have been published in the journal Neuron. Brain function depends on the active communication between nerve cells, known as neurons. For this purpose, neurons are woven together into a dense network where they constantly relay signals to one another. However, neurons do not form direct contacts with each other. Instead they are separated by an extremely narrow gap, known as the synapse. This gap is bridged by 'neurotransmitters', which carry nerve signals from one cell to the next. Specific molecular complexes in the cell's outer shell, so-called 'receptors', receive the signal by binding the neurotransmitters. This triggers an electrical impulse in the receptor-bearing cell and thus the nerve signal has moved on one neuron further. In the current study, a team led by Dr Jakob von Engelhardt focused on the AMPA receptors. These bind the neurotransmitter glutamate and are particularly common in the brain. "We looked at AMPA receptors in an area of the brain, which constitutes the main entrance to the hippocampus," explains von Engelhardt, who works for the DZNE and DKFZ. "The hippocampus is responsible for learning and memory formation. Among other things it processes and combines sensory perception. We therefore asked ourselves how the flow of information into the hippocampus is controlled." A pair of helpers Dr von Engelhardt's research team specifically focused on two protein molecules: 'CKAMP44' and 'TARP Gamma-8'. These proteins are present, along with AMPA receptors, in the 'granule' cells, which are neurons that receive signals from areas outside of the hippocampus. It was already known that these proteins form protein complexes with AMPA receptors. "We have now found out that they exert a significant influence on the functioning of glutamate receptors. Each in its own way, as chemically they are completely different," says the neuroscientist. "We identified that the ability of a nerve cell to receive signals doesn't depend solely on the actual receptors; CKAMP44 and TARP Gamma-8 are just as important. Their function cannot be separated from that of the receptors." This was the result of an analysis in which the researchers compared brain tissue from mice with a natural genotype with brain tissue from genetically modified mice. Neurons in the genetically modified animals were not able to produce either CKAMP44 or TARP Gamma-8 or both. The researchers discovered, among other things, that both proteins promote the transportation of glutamate receptors to the cell surface. "This means they influence how receptive the nerve cell is to incoming signals," says von Engelhardt. However, the number of receptors and thus the signal reception can be altered by neuronal activity. The von Engelhardt group found that in this regard the auxiliary molecules have different effects: TARP Gamma-8 is essential to ensure that more AMPA receptors are integrated into the synapse following a plasticity induction protocol, whereas CKAMP44 plays no role in this context. "Synapses alter their communication depending on their activity. This ability is called plasticity. Some of the changes involved are only temporary, others may last longer," explains von Engelhardt. "TARP Gamma-8 influences long-term plasticity. It makes the cell able to strengthen synaptic communication for a prolonged time-period. The larger the number of receptors on the receiving side of the synapse, the better the neuronal connection." The number of receptors doesn't change suddenly, but remains largely stable for a certain amount of time. "This condition may last for hours, days or even longer. This long-term effect is essential for the creation of memories. We can only remember things if the connections between neurons undergo a long-lasting change," says the scientist. Fast sequence of signals However, CKAMP44 and TARP Gamma-8 also act over shorter periods of time. The research team discovered that the molecules affect how quickly the AMPA receptors return to a receptive state. "If glutamate has docked on to a receptor, it takes a while until the receptor can react to the next neurotransmitter. CKAMP44 lengthens this period. In contrast, TARP Gamma-8 helps the receptor to recover more quickly," says von Engelhardt. Hence, CKAMP44 temporarily weakens the synaptic connection, while TARP Gamma-8 strengthens it. Through the interplay of these proteins the synapse is able to tune its sensitivity to a specific level. This condition can last from milliseconds to a few seconds before the strength of the connection is again adapted. Specialists refer to this as "short-term plasticity". "These molecules ultimately influence how well the nerve cell is able to react to a rapid succession of signals," the scientist summarises the findings. "Such a rapid firing enables neuronal networks to synchronize their activity, which is a common process in the brain." Much to the researchers' surprise, it turned out that the two proteins influence not only the synapse but also the shape of the nerve cells. In the absence of these auxiliary molecules, the neurons have fewer dendrites to establish contact with other nerve cells. "The organism can use CKAMP44 and TARP Gamma-8 molecules to regulate neuronal connections in a number of ways," von Engelhardt says. "This ability depends on the balance between the partners, as to some extent they have a contrary effect. The way in which the neurons of the hippocampus react to signals from other regions of the brain is therefore highly dependent on the presence and the expression ratio of these molecules." Since the two molecules act directly on the structure and function of synapses of granule cells, Jakob von Engelhardt considers it probable that they also have an influence on learning and memory.
In this blog our sustainable building expert Vilma Autio answers questions about the planning and building process of an accessible pilot dry toilet. Why did WASH and Grow! build an accessible dry toilet? The aim of the accessible latrine pilot was to enhance accessibility of the current Mifuko Trust latrine model while at the same time retaining the desirable chamber volume of at least one cubic meter and minimizing price increase. Accessibility is considered a crucial dimension in all human-rights based WASH projects. WASH activities are traditionally designed for ‘average’ persons in communities. Consequently, a large number of people are excluded from many WASH activities and facilities. However, every community is made up of a variety of individuals with a wide range of needs. For example, approximately 15 per cent of the world’s population, 1 billion people, live with disabilities. The majority, about 80 per cent, live in the Global South. Many of them are among the poorest, most marginalised and excluded groups in their communities. Access to safe and clean water and sanitation facilities is a basic right of all people, including children, persons with disabilities and older people. Improved access to WASH activities in community settings has a great impact on the health, hygiene, cleanliness, dignity and quality of life of persons with disabilities and other marginalised groups. Better access to such activities increases independence of marginalised persons while reducing the workload of family members in care-giving tasks. Accessible facilities are easier and safer to reach and use, resulting in a reduction of injuries. An inclusive approach can benefit diverse user groups and can offer a user-friendly and safer option for many community members. How was the planning process? Before revising the plans for the accessible toilet, the project team composed a best practice overview of accessible sanitation solutions by other organizations such as the Global Dry Toilet Association Finland, Disability Partnership Finland and GIZ (German Corporation for International Cooperation). The community members from various households in the project area in Makueni were also consulted. Plans for a fully accessible latrine model were then made based on these findings and they were reviewed by the beneficiaries before beginning the construction. What are the accessibility features of the toilet and which materials are used? The proposed latrine model is fully accessible for people utilizing a wheelchair or crutches as a mobility aid, or people who may need assistance or have otherwise reduced mobility. This also includes elderly people, who may find stairs and high thresholds difficult and may prefer to use a toilet with a seating option instead of the squatting toilet. Likewise people with for example impaired vision may find using this kind of toilet model more comfortable. The main accessibility features of the latrine include the following: • dimensioning spaces so that they cater to wheelchair users or persons who may need an assistant to use the latrine • removing thresholds that may propose a risk of tripping • replacing stairs with a ramp (with limited slope) to ensure easy access to the toilet space • enabling a movable seat option as well as a squatting option • installing proper hand rails where needed • installing wider doors • ensuring that hand washing station is easily reachable to all users The latrine was made using similar construction materials as the previous latrines, compressed earth bricks being the main material for walls, cement for the floor slab and wood and iron sheets for the roof. Materials should be durable and easy to keep clean. Where to build these kind of toilets? Ideally this would be a suitable model for a regular household toilet, however balancing accessibility and affordability is something that needs careful consideration. This kind of fully accessible latrine model is especially suitable for use in public spaces, such as educational and health care institutions and cultural institutions, where there is a need to cater to a large number of users with different abilities and needs. How shall we use the lessons learnt in the future of WASH and Grow!project? The pilot is a model that caters very well to the needs of all kinds of users, even those with severely impaired mobility, and would ideally be replicated for all beneficiary households. However, restraints related to cost and plot size need to be taken into consideration. The pilot can be presented as an example to households to showcase the level of accessibility that can be reached via considerate design and some extra cost. However, the model should be tailored to suit each household’s needs; even though future needs related to accessibility cannot be accurately forecasted as each individual’s abilities may vary greatly during their life due to for example illness, injury or aging. The best option may be to construct future toilets so that they can be utilized by persons of different ages and persons with minor disabilities related to mobility, and that can later be revised to cater to people with more severe disabilities if need be.
से सड़क मार्ग से जुड़ा है साथ ही इस क्षेत्र में मैट्रो भी जल्द ही शुरू होने वाली है। भारतीय रियल्टी केप्रबंध निदेशक और प्रमुख कार्यकारी एस के सयाल ने कहा कि हमें यह सूचित कर बहुत खुशी हो रही है कि हमने ईरॉस के साथ स्मार्ट परियोजना केे लिए करार किया है जो एनसीआर क्षेत्र मेंं आवासीय परियोजना क्षेत्र मेंं एक नया मानक स्थापित करेगी। और तस्वीरें देखिए यहां पर.. जानकारी के मुताबिक, मामला पाली जिले के गणेश नगर का है। यहां शनिवार सुबह 11 बजे मोहम्मद इकबाल टैक्सी खड़ी कर सुनसान इलाके की तरफ जाने लगा तो वहां से गुजर रही मोहल्ले की महिलाओं को उसके चलने के तरीके पर संदेह हुआ। इस पर महिलाओं ने उसे बच्चा चोर समझकर शोर मचा दिया। सेंचुरियन में भी चार तेज़ गेंदबाज करेंगे हमला : गिब्सन खुशहाली और सेक्स एकदूसरे के पूरक निगम क्षेत्र के अधिकांश जल कमल कलश बंद है। गर्मी बढ़ने के साथ ही इनकी उपयोगिता को ध्यान में रखते हुए उसे चालू किया जाएगा। इसके लिए कोशिश शुरू कर दी गई है। बहरहाल अब कोई जवाहरलाल नेहरू का अभिनय करना चाहे तो उसे कोई रोक नहीं सकता है इसलिए आज फूलपुर में राहुल गांधी का भाषण उसी तर्ज़</s>
Definitions of diffusion n. - The act of diffusing, or the state of being diffused; a spreading; extension; dissemination; circulation; dispersion. 2 n. - The act of passing by osmosis through animal membranes, as in the distribution of poisons, gases, etc., through the body. Unlike absorption, diffusion may go on after death, that is, after the blood ceases to circulate. 2 The word "diffusion" uses 9 letters: D F F I I N O S U. No direct anagrams for diffusion found in this word list. Words formed by adding one letter before or after diffusion (in bold), or to dffiinosu in any order: s - diffusions All words formed from diffusion by changing one letter Browse words starting with diffusion by next letter
जा रहे हैं तो इस बात की आशंका बढ़ रही हे कि ये निजी सेनाएं उन क्षेत्रों में खूब उत्पात मचाएंगी जहां उनके नेता को कम वोट मिलने का डर होगा। पर किसे फर्क पड़ता है कि उन दंगों में कितनी बड़ी मात्रा में लोग मारे भी जाते है। देखिए अयोध्या के आसपास क्या हो रहा है? बाबरी मस्जिद विवाद में अभी अदालत का फैसला आना है, पर शिवसैनिकों का जमवाड़ा वहां हो गया है। उन्होंने मुसलमानों और दलितों को इतना डरा दिया है कि वे लोग अपने घरबार छोड़ कर भाग रहे हैं। सिंघु बॉर्डर पर रोके गए किसानों की तरफ से कहा गया कि वह शांतिपूर्ण प्रदर्शन कर रहे हैं और इसे जारी रखेंगे. दूसरी ओर दिल्ली पुलिस ने दिल्ली सरकार से 9 स्टेडियम को अस्थाई जेल बनाने की इजाजत मांगी. प्रदर्शन कर रहे किसानों को गिरफ्तार करके इन जगहों पर लाया जाएगा. होम देश आर्मीनिया और अजरबैजान की लड़ाई में महाशक्तियां दे सकती हैं दखल, अड़ा... कांग्रेस महासचिव प्रियंका गांधी वाड्रा ने मंगलवार को दावा किया कि उत्तर प्रदेश में महिलाओं के खिलाफ अपराध की सैकड़ों घटनाएं होने के बाद भी योगी आदित्यनाथ सरकार की तरफ से महिला सुरक्षा के मुद्दे पर कोई हलचल नहीं दिख रही</s>
कोरोना के चलते पूरे देश में लॉकडाउन जारी है। इस दौरान शराब की दुकानें खोली गईं। शराब की बिक्री पर ७० प्रतिशत स्पेशल कोरोना टैक्स लागू किया गया था। अब ये मामला दिल्ली हाईकोर्ट में पहुंच गया है। दिल्ली हाईकोर्ट ने शराब पर ७० फीसदी कोरोना टैक्स लगाने पर अरविंद केजरीवाल सरकार से जवाब मांगा है। दिल्ली हाईकोर्ट के मुख्य न्यायाधीश डीएन पटेल और जस्टिस हरी शंकर की बेंच ने इस मसले पर सरकार को एक नोटिस जारी की है। जिसमें केजरीवाल सरकार को २९ मई तक जवाब देने का समय दिया गया है। हालांकि, पीटीआई के मुताबिक शुक्रवार को कोर्ट ने सरकार के टैक्स लगाने के फैसले पर फिलहाल रोक लगाने से इनकार कर दिया। कोर्ट ने कहा है कि दिल्ली सरकार का जवाब आने तक इंतजार करें उसके बाद इसपर फैसला किया जाएगा। सरकार के फैसले के खिलाफ याचिका दाखिल करने वाले याचिकाकर्ता ललित वेल्चा ने पीटीआई को बताया कि नोटिस जारी करते हुए अदालत ने कहा कि वह दिल्ली सरकार के जवाब का इंतजार करेंगे और फिलहाल के लिए इस पर अंतरिम स्थगन लगाने से इनकार कर दिया। वहीं दिल्ली सरकार के स्थायी वकील रमेश ने प्रशासन की तरफ से आई नोटिस को स्वीकार किया है। उन्होंने अतिरिक्त टैक्स वसूली को वैध ठहराने का संकेत देते हुए कहा कि इस संबंध में जल्द ही विस्तृत जवाब कोर्ट में दायर किया जाएगा। गौरतलब है कि दिल्ली सरकार ने तीन मई को १५० सरकारी शराब की दुकानों को खोले जाने की मंजूरी दी थी। सभी शराब की दुकानों में भीड़ उमड़ आई थी। ठीक एक दिन बाद सरकार ने शराब पर ७० फीसदी विशेष कोरोना शुल्कलगा दिया था। सरकार के इस फैसले के विरोध में बीते हफ्ते दिल्ली हाईकोर्ट में कई याचिकाएं दाखिल की गई थी। दाखिल याचिका में कहा गया है कि ७० फीसदी शुल्क बढ़ा देना गलत है।
We are often asked whether our 12 volt fridges can be run off the mains power while you're on a campsite hook-up. The short answer is no, not on their own... However, add an MPS box, and that is exactly what happens. Simply connect your 12volt supply and your 240v volt supply to the MPS unit - then plug your fridge into it. The MPS will automatically switch to using mains power to run your fridge whenever it's available. Why would you want to do this? Mainly because it allows your leisure battery to charge fully while you are hooked up to the mains, (without the fridge pinching power at the same time!). It allows your mains charger to operate as effectively as possible. Modern chargers go through several stages while charging up your battery but, if you are drawing power out at the same time as charging, that functionality is less effective. One other benefit of the MPS unit is that, in order to preserve battery power, you might choose to run your fridge 'colder' while on a mains supply - and then raise the thermostat setting when you are off-grid to use less power. - Switch mode, automatic priority for mains operation - Input voltage (AC) 110/230 V - Input voltage (DC) 12/24 V - Output voltage 24 V - Output current 3.00 A - Input frequency 50/60 Hz - IP class IP20 - Energy efficiency ≤87 % - Continuous power 25°C 75.00 W - Operating temperature min 0.00 °C - Operating temperature max 40.00 °C
The numerical description of case-hardening of PM-components requires material parameters in dependency of carbon concentration and porosity. Therefore a method to determine effective diffusion coefficients had to be developed. For quenching simulation the transformation behaviour was measured by quench-dilatometry, the mechanical beahviour was determined by deformation dilatometry and the thermo physical parameters were detected by DSC- and Laser-Flash testing. \|A mechanical surface treatment prior to case hardening enables to adjust a definite carbon profile during carburizing and so surface hardening of PM-components. The built-up numerical tools are able to predict the carbon depth profile and microstructure evolution in good agreement to the experimental results. The residual stress distribution, especially the compressive residual stresses in the surface layer, are overestimated. \| Nevertheless the simulations show the potential to describe case-hardening of graded porous PM-components.
What is it? Allergies are an abnormal response of the immune system. People who have allergies have an immune system that reacts to a usually harmless substance in the environment. This substance (pollen, mold, and animal dander, for example) is called an allergen. Allergies are a very common problem, affecting at least two out of every 10 Americans. Symptoms and Risks Sneezing, itchy, watery eyes, runny nose (clear discharge), coughing, nasal congestion, hives or other skin rash, headache and fatigue are some common symptoms of allergies. These symptoms may be mild to moderate but some allergic reactions can be severe and even life threatening. Skin prick test. This test is done by placing a drop of a solution containing a possible allergen on the skin, and a series of scratches or needle pricks allows the solution to enter the skin. If the skin develops a red, raised itchy area (called a wheal), it usually means that the person is allergic to that allergen. This is called a positive reaction. Other lab testing methods, such as radioallergosorbent testing (RAST) or an immunoassay capture test (ImmunoCAP, UniCAP, or Pharmacia CAP), may be used to provide more information. Your allergy test results may show that allergy treatment is a choice for you. There are several allergy treatment options. Over-the-counter and prescription medications can ease annoying symptoms. Allergy shots also help.
The world view of the people that lived in ancient Finland in pre-written times was animistic. They believed that everything in nature had it´s own soul and spirit. Animals were part of nature and they all had their own soul and spirit living inside them as well. Agriculture arrived at what is now known as Finland about 7000 years ago but even after it´s arrival fishing and hunting remained an important part of the culture. One of the most common elements in old Finnish folk belief was the connection to elements; earth, fire, air, and water. Especially elements of water and the earth were essential because they were closest to humans. Invisible spirits, animals, and plants were divided to represent different elements. Role of the animals was important and they often appear in Finnish folk songs and folk magic. In Finnish ancient pagan world view, väki is a common concept. Väki is the power and energy that flows through in every living being. Each element had its own väki. Men and women had their own väki. Forest had its own väki. Fire, iron and the dead all possessed väki. Väki of the animals was especially strong because their väki was always connected to their living environment. Ants belonged to earth and they represented the spirit of the forest. When the family moved into a new place they lifted stones to see which colored ants there was underneath. These colors had different symbolical meanings. In Finland and in Sweden there was a belief that spirit of a passed away relative could appear as an ant. Snakes were widely worshipped all across ancient Finland and Baltic countries. First literal mentions of keeping pet snakes come from the 16th century. Snakes were fed with cow´s or sheep´s milk and they were considered to be protectors of houses and buildings. Harming snakes was a serious crime. Snakes were sacred animals of the earth goddess Akka. Spring Equinox was known as Matopäivä in ancient Finland, ”day of the snakes”. During Spring Equinox Akka woke up from her winter sleep and snakes woke up from hibernation. They rose from the soil and danced in her honour. During this day it was forbidden for people to do any kind of housework that would implicate to snakes. Deers were connected to the power of the forest. A person who had eaten deer´s brains would see constant nightmares of dark creatures of the forest. Bears were the most worshipped animals in ancient Finland. In some areas, bears were even considered as gods. In Eastern Finland, there was a belief that bear was the sacred ancestor of the clan so the eating bear meat was forbidden. In western Finland bear hunting was common and bear meat was considered as a real treat. There is lots of archaeological evidence of bear cult and bear worship found from Finland. The bear was considered to be both a mythical ancestor and manifestation of the forest. Huntress goddess Mielikki and her husband forest god Tapio both had the ability to shapeshift themselves into bears. When a child dropped their first teeth that teeth were put into the oven and left as a sacrifice for the spider. It was believed that the spider would bring a new teeth rautahammas ”iron teeth” for the child. Passed away relatives could appear in the form of a spider. In the oldest layer of Finnish folklore, frogs were believed to be ancient water spirits. Väki of water was considered to be extremely powerful therefore frogs and fishes were often used in spells. In the Middle Ages frogs (and lizards) were demonized by the Catholic church and there was lots of superstitions and suspicions connected to them. Folk poems of the time describe frogs as spirits of children that were given birth in secret and we're left to marches to die by their mothers. In Finnish folklore, cats were protector spirits of buildings and cats were often kept as pets because they killed rodents. Witch hunts arrived in Finland and Sweden rather late compared to the rest of Europe and in Finland cats never had a reputation of being a witch´s pets so there never was massive cat burnings in Finland like there was in many other parts of Europe. In Finnish mythology, the cat was created in the sauna by tonttu (elf). It was believed that tonttu´s could shapeshift themselves into animals and take forms of a white cat. In some occasions, white cats were believed to be spirits of passed away relatives. Horses had an important role in the agrarian society. The first horse was called Iku-Tihku and it was made by the trolls inside a mountain. Iku-Tihku was made of fire and ice and it was a shamanic traveller. Ancient Finnish tribes believed that the world was made of different levels. Ylinen the upper world where the highest of the spirits lived. Keskinen the Middle world where animals, humans and elemental deities lived and Alinen the underworld, place of the dead. Iku-Tihku could only visit the Middle world during the wintertime because it would melt away in the summer. Trolls used Iku-Tihku as the prototype when they made other horses but they were all made of iron. Most often little birds were seen as good omens. If there was lots of little bird in the yard in the winter that would mean good crop for the next summer. Little birds were believed to be souls of passed away children. When a person took their last breath it was believed that their soul would fly away as a butterfly. Forest rabbits are very common animals in Finland. During winter time their fur changes it´s color to white to blends into the snow. In folklore, rabbit symbolizes intuition, learning, and cleverness. They were common magician´s familiars. Pronounced as Nee-na. Artist, illustrator, writer, watercolorist and a folklorist. Gryffinclaw. Comes from Finland. Likes cats, tea and period dramas. Love fandoms AOGG and Little Women (prefers books over the films). Louisa May Alcott researcher. Please keep the comment section civil, respectful and connected to the topic at hand. Thank you. Spammy/passive-agressive comments will be blocked and reported. Get 2 free weeks on Skillshare. Click here to edit.
The AN/SPS-55 is a solid state, surface search and navigation radar capable of detecting targets from as close in as 50 yards and out to 50 miles and beyond, with good target resolution. The radar set uses several signal processing circuits to improve operation under certain prevailing conditions: Radar Set AN/SPS-55 consists of four major units: antenna group, radar receiver/transmitter, radar set control, and box switch. The system generates two selectable pulse widths. The RF frequency is tunable from 9.05 to 10.0 GHz with a minimum peak power out of 130 kW (measured at the magnetron). The linear array antenna, rotating in azimuth at 16 RPM, forms a beam narrow in azimuth (1.5°) and broad in elevation (-10° to +10°, centered on the horizon). Return target echoes are amplified and detected by the receiver and applied to a PPI. The target information can be displayed in either of two modes, a relative mode where zero degrees bearing on the PPI represents the heading of the ship or a true mode where zero degrees bearing - Fast Time Constant (FTC) circuit - Reduces clutter by displaying only the leading edge of the echo returns. - Sensitivity Time Control (STC) circuit - Reduces receiver gain at close-in ranges where clutter is strong, while allowing a gradual return to normal gain at longer ranges where clutter is less. - Sector Radiate Capability - Allows the operator to limit radiation to a selectable azimuth segment to minimize interference from other ships' radars or ECM equipment. Sources and Resources Maintained by Robert Sherman Originally created by John Pike Updated Tuesday, December 15, 1998 7:42:42 AM
""" Given two arrays, write a function to compute their intersection.""" class Solution: def intersect(self, nums1: List[int], nums2: List[int]) -> List[int]: res = [] x1, x2 = 0, 0 nums1.sort() nums2.sort() while x1 < len(nums1) and x2 < len(nums2): if nums1[x1] == nums2[x2]: res.append(nums1[x1]) x1 += 1 x2 += 1 elif nums1[x1] > nums2[x2]: x2 += 1 else: x1 += 1 return res # Solution 2 import collections res = [] x = collections.Counter(nums2) # or nums1, whatever. for n in nums1: if n in x and x[n] > 0: # it's True even if it's 0 res.append(n) x[n] -= 1 return res
MAYHEM The Solar and Heliospheric Observatory Spacecraft (SOHO) captured this image of a huge, curling solar prominence as it erupted from the sun on July 1, 2002. Prominences are huge clouds of relatively cool, dense plasma suspended in the sun's hot corona. Magnetic fields built up enormous forces that propelled particles out beyond the sun's surface. Emission in this spectral line shows the upper chromosphere at a temperature of about 60,000 degrees Kelvin (107,540 degrees Fahrenheit). NASA said the prominence appears to extend a distance of at least 30 times the diameter of Earth but would not head toward the planet. SOHO is a joint NASA/European Space Agency venture that observes the sun 24 hours a day.
Join the world in the celebration of International Thank You Day on Sunday 11 January 2015! Here are some beautiful Thank You Quotes that you can use in cards or just send via social media! Which one is your favourite? - Saying thank you is more than good manners.� It is good spirituality.� ~Alfred Painter - Kindness is the language which the deaf can hear and the blind can see.� Mark Twain - Unselfish and noble actions are the most radiant pages in the biography of souls.� ~David Thomas - I would maintain that thanks are the highest form of thought, and that gratitude is happiness doubled by wonder.� ~G.K. Chesterton - What we do for ourselves dies with us. What we do for others and the world remains and is immortal.� - Forget injuries, never forget kindnesses.� ~Confucius - Gratitude is the memory of the heart.� ~Jean Baptiste Massieu, translated from French - It’s nice to be important, but it’s more important to be nice.� ~Author Unknown - How beautiful a day can be When kindness touches it! - If the only prayer you said in your whole life was, “thank you,” that would suffice.� - Gratitude is not only the greatest of virtues, but the parent of all the others.� - The roots of all goodness lie in the soil of appreciation for goodness. The Dalai Lama - Feeling gratitude and not expressing it is like wrapping a present and not giving it.� William Arthur Ward Need to say a special Thank You? Send some thank you flowers from serenataflowers.com!Source: quotegarden.com & � write-out-loud.com
When computer scientist Christian Berger’s team sought to get its project about self-driving vehicle algorithms on the road, it faced a daunting obstacle. The scientists, at the University of Gothenburg in Sweden, found an overwhelming number of papers on the topic — more than 10,000 — in a systematic literature review. Investigating them properly would have taken a year, Berger says. Luckily, they had help: a literature-exploration tool powered by artificial intelligence (AI), called Iris.ai. Using a 300-to-500-word description of a researcher’s problem, or the URL of an existing paper, the Berlin-based service returns a map of thousands of matching documents, visually grouped by topic. The results, Berger says, provide “a quick and nevertheless precise overview of what should be relevant to a certain research question”. Iris.ai is among a bevy of new AI-based search tools offering targeted navigation of the knowledge landscape. Such tools include the popular Semantic Scholar, developed by the Allen Institute for Artificial Intelligence in Seattle, Washington, and Microsoft Academic. Although each tool serves a specific niche, they all provide scientists with a different look at the scientific literature than do conventional tools such as PubMed and Google Scholar. Many are helping researchers to validate existing scientific hypotheses. And some, by revealing hidden connections between findings, can even suggest new hypotheses for guiding experiments. Such tools provide “state-of-the-art information retrieval”, says Giovanni Colavizza, a research data scientist at the Alan Turing Institute in London, who studies full-text analysis of scholarly publications. Whereas conventional tools act largely as citation indices, AI-based ones can offer a more penetrating view of the literature, Colavizza says. That said, these tools are often expensive, and limited by the fraction of the scientific literature they search. “They are not meant to give you an exhaustive search,” says Suzanne Fricke, an animal-health librarian at Washington State University in Pullman, who has written a resource review on Semantic Scholar (S. Fricke J. Med. Lib. Assoc. 106, 145–147; 2018). Some, for example, “are meant to get you quickly caught up on a topic, which is why they should be used in conjunction with other tools”. Berger echoes this sentiment: “Blindly using any research engine doesn’t answer every question automatically.” Teaching science to machines AI-based ‘speed-readers’ are useful because the scientific literature is so vast. By one estimate, new papers are published worldwide at a rate of 1 million each year — that’s one every 30 seconds. It is practically impossible for researchers to keep up, even in their own narrow disciplines. So, some seek to computationally tame the flood. The algorithms powering such tools typically perform two functions — they extract scientific content and provide advanced services, such as filtering, ranking and grouping search results. Algorithms extracting scientific content often exploit natural language processing (NLP) techniques, which seek to interpret language as humans use it, Colavizza explains. Developers can use supervised machine learning, for example — which involves ‘tagging’ entities, such as a paper’s authors and references, in training sets to teach algorithms to identify and extract them. To provide more-advanced services, algorithms often construct ‘knowledge graphs’ that detail relationships between the extracted entities and show them to users. For example, the AI could suggest that a drug and a protein are related if they’re mentioned in the same sentence. “The knowledge graph encodes this as an explicit relationship in a database, and not just in a sentence on a document, essentially making it machine readable,” Colavizza says. Iris.ai takes a different approach, Colavizza notes, grouping documents into topics defined by the words they use. Iris.ai trawls the CORE collection, a searchable database of more than 134 million open-access papers, as well as journals to which the user’s library provides access. The tool blends three algorithms to create ‘document fingerprints’ that reflect word-usage frequencies, which are then used to rank papers according to relevance, says Iris.ai chief technology officer Viktor Botev. The result is a map of related papers, but eventually the company plans to supplement those results by identifying hypotheses explored in each paper as well. It is also developing a parallel, blockchain-based effort called Project Aiur, which seeks to use AI to check every aspect of a research paper against other scientific documents, thus validating hypotheses. Colavizza says that tools such as Iris.ai — free for basic queries, but costing upwards of €20,000 (US$23,000) a year for premium access, which allows more-nuanced searches — can accelerate researchers’ entry into new fields. “It facilitates initial exploration of the literature in a domain in which I’m marginally familiar,” he says. Experts seeking deeper insights into their own specialities might consider free AI-powered tools such as Microsoft Academic or Semantic Scholar, Colavizza suggests. Another similar option is Dimensions, a tool whose basic use is free but which costs to search and analyse grant and patent data, as well as to access data using the programmable Dimensions Search Language. (Dimensions is created by technology firm Digital Science, operated by the Holtzbrinck Publishing Group, which also has a majority share in Nature’s publisher.) Semantic Scholar has a browser-based search bar that closely mimics engines such as Google. But it gives more information than Google Scholar to help experts to prioritize results, Colavizza says. That includes popularity metrics, topics such as data sets and methods, and the exact excerpt in which text is cited. “I was very surprised to find that they also capture indirect citations,” Colavizza adds — such as when a method or idea is so well established that researchers don’t refer to its origin. Doug Raymond, Semantic Scholar’s general manager, says that one million people use the service each month. Semantic Scholar uses NLP to extract information while simultaneously building connections to determine whether information is relevant and reputable, Raymond says. It can identify non-obvious connections, such as methodologies in computer science that are relevant to computational biology, he adds, and it can help to identify unsolved problems or important hypotheses to validate or disprove. Currently, Semantic Scholar incorporates more than 40 million documents from computer and biomedical science, and its corpus is growing, says Raymond. “Ultimately, we’d like to incorporate all academic knowledge.” For other tools, such as SourceData from the European Molecular Biology Organization (EMBO) in Heidelberg, Germany, experimental data are a more central concern. As chief editor of Molecular Systems Biology, an EMBO publication, Thomas Lemberger wants to make the data underlying figures easier to find and interrogate. SourceData therefore delves into figures and their captions to list biological objects involved in an experiment, such as small molecules, genes or organisms. It then allows researchers to query those relationships, identifying papers that address the question. For instance, searching, ‘Does insulin affect glucose?’ retrieves ten papers in which the “influence of insulin (molecule) on glucose (molecule) is measured”. SourceData is at an early stage, Lemberger says, having generated a knowledge graph comprising 20,000 experiments that were manually curated during the editing process for roughly 1,000 articles. The online tool is currently limited to querying this data set, but Lemberger and his colleagues are training machine-learning algorithms on it. The SourceData team is also working on a modified neuroscience-focused version of the tool with an interdisciplinary neuroscience consortium led by neurobiologist Matthew Larkum at Humboldt University in Berlin. Elsewhere, IBM Watson Health in Cambridge, Massachusetts, announced in August that it will combine its AI with genomics data from Springer Nature to help oncologists to define treatments. (Nature’s news team is editorially independent of its publisher.) Among those embarking on hypothesis generation are the roughly 20 customers of Euretos, based in Utrecht, the Netherlands. Arie Baak, who co-founded Euretos, explains that the company sells tools to industry and academia, mainly for biomarker and drug-target discovery and validation, for prices he did not disclose. Euretos uses NLP to interpret research papers, but this is secondary to the 200-plus biomedical-data repositories it integrates. To understand them, the tool relies on the many ‘ontologies’ — that is, structured keyword lists — that life scientists have created to define and connect concepts in their subject areas. Baak demonstrates by searching for a signalling protein called CXCL13. Above the resulting publication list are categories such as ‘metabolites’ or ‘diseases’. The screen looks much like Google Scholar or PubMed at this stage, with an ordered list of results. But clicking on a category reveals extra dimensions. Selecting ‘genes’, for instance, pulls up a list of the genes associated with CXCL13, ranked by how many publications mention them; another click brings up diagrams illustrating connections between CXCL13 and other genes. Researchers at the Leiden University Medical Centre (LUMC) in the Netherlands have shown that this approach can yield new hypotheses, identifying candidate diseases that existing drugs might treat. The team presented its results at the Semantic Web Applications and Tools for Health Care and Life Sciences meeting in Rome in December 2017. They have also used Euretos to identify gene-expression changes in a neurological disorder called spinocerebellar ataxia type 3 (L. Toonen et al. Mol. Neurodegener. 13, 31; 2018). So, should researchers worry that AI-based hypothesis generation could put them out of a job? Not according to Colavizza. Hypothesis generation is a “very challenging ambition”, he says, and improvements initially will be incremental. The hypotheses suggested so far are therefore “mostly in the realm of the relatively unsurprising ones”, Colavizza says. That will probably change, of course. But surprising or not, computer-generated hypotheses must still be tested. And that requires human researchers. “One should never believe an auto-generated hypothesis first-hand without investigating the underlying evidence,” warns LUMC researcher Kristina Hettne. “Even though these tools can assist in collecting the known evidence, experimental validation is a must.” Nature 561, 273-274 (2018)

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YALM Pretraining Data - 5

The YALM Pretraining Data - 5 is a mix of English, Hindi, Math and Python Code taken from various sources for the Language modeling task and development of YALM(Yet Another Language Model).

Total Samples: 59M (~36B tokens with sample packing at 2048 Context)

Test Split: 6k Samples

Shuffle Seed: 101

Datasets:

English(70%):
- openbmb/Ultra-FineWeb
  - Language: English
  - Subset: en
  - Sources: fineweb
Hindi(20%):
- zicsx/mC4-Hindi-Cleaned
  - Language: Hindi
- anirudhlakhotia/baarat-batched-hindi-pre-training
  - Language: Hindi
Math(5%):
- HuggingFaceTB/finemath
  - Language: English
  - Subset: finemath-4plus
Code(5%):
- Avelina/python-edu-cleaned
  - Language: Python

Downloads last month: 36

Size of downloaded dataset files:

125 GB

Size of the auto-converted Parquet files:

125 GB

Number of rows:

59,256,976