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This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | It is unclear whether these changes are preserved during longer walnut supplementation and how these changes are associated with the observed changes in lipid metabolism. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Thus, CD4 cell count is one of the indicators of disease progression in HIV/AIDS and therefore can potentially influence a person’s self-perception of QoL. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In summary, in this prospective cohort of IBS-D patients who were not selected on the basis of prior response to a GFD, carriers of HLA-DQ2/8 actually had slower colonic transit than HLA-DQ2/8-negative patients. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, in the subsequent warming blastocyst-transfer (BT) cycles of our study, we noted that the low oxygen group resulted in more favorable clinical outcomes. |
This is a strong advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, this approach has been found to be often inadequate to attain long-term benefit (Keller and Boland, 1998; Montgomery and Kasper, 1998) and drugs that can be recommended for prophylaxis should offer good long-term tolerability at the full therapeutic dose. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In addition to the 4 myxomas in this study, 1 thrombus and 1 malignant fibrous histiocytoma had attachments to the interatrial septum. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | These patients are probably at the upper end of the coeliac disease fracture risk spectrum, but bone mineral density studies in coeliac disease suggest that as many as 40% of patients may have osteoporosis, with associated increased lifetime fracture risk. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Administration of bicarbonate is safe as we did not see severe hypokalemia or hypernatremia in our patients. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | After car ownership, age and gender may be the next most influential factors as studies found that women exercise less compared to men and that people are less active as they get older [70,71]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This is a hypothesis we are currently testing in our paradigm. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We observed a higher case fatality among patients from poorer households, and while a multitude of factors undoubtedly contributed to this excess mortality, it underlines the urgency of reducing delays wherever possible. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In view of these findings, the association between self-medication and beliefs in Specific-Necessity, General-Harm and General-Overuse could be attributed to the fact that patients with high positive beliefs about analgesics (Specific-Necessity) and low negative beliefs about medicines (General-Harm and General-Overuse) tend to perceive analgesic as a potential cure to dental pain. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Whether individuals are faced with addiction, serious mental illness, HIV/AIDS, or other disabilities (Rhoades, Browning, & Thorin, 1987), there is a value to increases in tolerance toward others and an esteem boost in relation to their own and society's perceptions of their conditions (Mayville & Penn, 1998). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | A further limitation is that our study considered residential food environment only. |
This is a strong advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | These characteristics are properties of an international high-risk clone (1) and underline that ST410 qualifies as a lineage with new international multidrug-resistant high-risk clones, which should be monitored closely in the future. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | They are also in keeping with anatomically constrained magnetoencephalography, which has revealed an anterior temporal supramodal convergence area involved in word comprehension (Marinkovic et al, 2003). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | One such intervention could be financial incentives for smoking cessation (Volpp et al, 2009). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In the present study, the rate of patients who had had mammography screening was 13.3%, and the rate of patients who had never had any screening tests was 68.9%. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Our main finding is that only 4.7% of people with SMI were screened for HCV infection over a 1-year period. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | 3.0T systems have higher signal-to-noise ratio (SNR) and CNR than 1.5T [16–19]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Since the aim of a screening program is to provide a decrease in morbidity and mortality due to the target disease the screening tests should be inexpensive, easy to perform and accessible to everyone (Baskan et al, 2012). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Fallers and non-fallers have greater gait variability than the young, as they are older, frailer, and in turn may not have the same intact sensory and motor function. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Mongolian ethnicity in Russia, Republic of Mongolia, and Inner Mongolia of China. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In the present study, low oxygen cultivation had more high quality cleavage-embryos and blastocysts available for cryopreservation, providing patients with more opportunities for achieving pregnancy. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Interestingly, during fibrosis progression, immune cells secret a variety of growth factors and inflammatory cytokines including IL-6, IFN-γ, IFN-α/β, and IL-22, which have been shown to play key roles in regulating liver fibrogenesis resulting in collagen deposition and the disruption of the normal liver architecture29,30. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | These organizations have jointly issued a position paper advocating instrument-based vision screening for children between the ages of 6 months and 3 years 5. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | It was problematic to use genes from the study of Nakagawa et al5 for functional annotation because those genes were selected on the basis of published evidence of their involvement in prostate cancer progression. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Estrogen administration in ovariectomized rats mutes glucocorticoid negative feedback, resulting in higher ACTH levels, whether corticosterone or a synthetic glucocorticoid is administered by single bolus injection to test fast feedback via nongenomic mechanisms (25) or infused continuously to test slow feedback via nuclear glucocorticoid receptors (4). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The solubility of gases in liquids changes with temperature. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Unexpectedly, the association detected for the sequence variant nearest to MS4A4E (rs670139) and a test of delayed word recall in whites was in the opposite direction from expectation based on the association with AD in the GWAS. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The differential effect of poverty on different age strata has more than one plausible explanation. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, there was no major difference in prediction capability between the two risk scores for all fractures. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In conclusion, BMIz trajectories in the first 2 years were associated with cardio-metabolic measures later in childhood, which in turn are known predictors of cardio-metabolic outcomes in adult life. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In human colorectal cancer, the intensity of angiogenin detection has been shown to correlate with microvessel density and focal macrophage infiltration [40]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Continuous infusion of remifentanil during general anesthesia in minor surgery may not be superior to volatile anesthesia without opioid in terms of overall complications. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This treatment strategy may lead to more favorable outcomes. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | CRP, produced by the liver as an acute phase protein, is a nonspecific marker generated in response to inflammatory stimuli. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In our study, food vendor density within 400 m buffer had a closer relationship with cardiovascular risk factors than density within 1600 m buffer and distance to the nearest food vendor. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Such daily separation intervals are similar to our maternal separation paradigm, since rat pups were separated from the dam for 45 min total/day, much longer then is typical for “handling” paradigms. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Therefore, pulmonary resection surgery has been advocated for selected patients who have localized disease and are able to tolerate resection to remove gross lesions that contain large numbers of bacilli (citation). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | One major limitation associated with the TSP approach, however, is that a large number of tests can lead to a large number of false-positive results. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In contrast, analyses of 158 SNPs in 11 genes involved in AD including BIN1, CLU, CR1, and PICALM showed no significant association with cognitive phenotypes such as a test of verbal fluency similar to the WFT in 505 participants from the Lothian Birth Cohort of 1921(mean age 79.1 years) and 998 participants from the Lothian Birth Cohort of 1936 (mean age 69.6 years) [Hamilton et al 2011]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Measurement issues pose challenges. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Although the NLR is limited in providing all necessary information as a predictive marker, it can still complement other inflammatory markers in predicting HCA. |
This is a weak advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Examples of such interventions could be; training school teachers to identify social anxiety among students or recruiting a psychological counselor; emphasizing on group learning activities so that fear of talking with people could be minimized. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Especially, AFM showed a similar trend regarding the profile of naïve and memory B and T cells, with significantly increased transitional B cells, CD4+ TCM cells and CD8+ TCM cells and significantly decreased IgD−CD27+ memory B cells, plasmablasts and CD4+ RTE compared to HC. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We found that maternal adiposity-related factors (ppBMI, GWG) were associated with BMIz trajectories reflecting larger child size (stable high-weight and rapid weight gain). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Phenotypic changes in repopulated B cells could account for this change in clinical course. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, when NPM/ALK expression was knocked out using an inducible siRNA silencing system, no significant evidence of BIM locus reacetylation could be found (Figure 6, C and D), suggesting that NPM/ALK expression is dispensable from maintaining BIM epigenetic silencing and that other, yet unknown pathways are required to maintain this process, probably involving DNMT1. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | ANP pretreatment reduces serum TNF-α levels and NF-κB activation by inhibiting IκB-phosphorylation in mice injected with LPS (29) and has a protective role against LPS-induced lung injury and endothelial barrier dysfunction (30). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | A recent study comparing three photoscreening devices showed Plusoptix to have good sensitivity and specificity compared to other devices. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Although the efficacy of intraoperative aprotinin in reducing postoperative bleeding seems confirmed by our results, its safety is still under investigation. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | There was, however, a systematic tendency towards higher numeric improvements in the PA group, ranging from 2.6 to 4.9 points on HOOS-Pain, HOOS-PS and HOOS-QOL, than in the LA group. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The characteristics of this Egyptian OXA-181/NDM-5-producing ST410 isolate correlate with the first OXA-181/NDM-5-producing ST410 isolate collected in Denmark, suggesting that the Danish patient, P1, most likely acquired the isolate during travel to Egypt in 2015. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Frequently, cross‐reactivity between species antibodies or elevated titers to more than one species is observed. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Our results showed that the 8-cm H2O PEEP could better improve ventilation (maximizing the recruitment of dependent lungs and minimizing the overdistension of nondependent lungs) and oxygenation (avoiding impairing PaO2/FiO2 and increasing the shunt upon the initiation of pneumoperitoneum) in patients undergoing laparoscopic surgery, without significantly interfering with other respiratory or hemodynamic parameters. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Infection status and history, via effects on acquired immunity, may also lead to individual and population-level differences in experienced tradeoffs with growth. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Third, we used convenience sampling: HIV-patients were recruited at a medical facility by the physicians, which may have increased the possibility of selection bias or decreased generalizability. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In our current study, we have shown that subjects treated with oxandrolone had a significantly higher MVV compared to untreated subjects (Figure 2), and that subjects treated with oxandrolone had a significantly higher VEMax compared to untreated subjects during maximal exercise (Figure 3). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The variability in aminoglycoside clearance was best explained by using a modified Cockcroft-Gault equation, omitting terms for weight and sex, with the addition of a morphomic measure of skeletal muscle mass. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Our results suggest that additional study is needed to test interventions to achieve BP control in this group of patients, who represented 21% of the study population. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In addition, the cardboard was only used for secondary packaging and was therefore not in direct contact with any food products. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | It should additionally be kept in mind that only the resting SPECT was repeated here for further comparisons of patient positions and that only patients with abnormal or at least doubtful stress SPECT findings in our current biker position could be included. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The combination of laparoscopic surgery and ERAS is not inferior to open, traditional surgery. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The agents used in the epidural space include an opioid and/or a local anesthetic, which can provide excellent analgesia with less systemic sedation (Desparmet, Hardart, & Yaster, 2003). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Although abstinence attempts continued throughout the 3-month study, the incidence of new quit attempts decreased over time. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | After accounting for biological sex, age group, onset age, and sexual orientation, the hormonal therapy status should affect the Masculinity/Femininity and Psychasthenia scores. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The vibrating sandals improved gait variability in fallers, but they did not reduce variability levels in elderly recurrent fallers to the baseline range of elderly non-fallers or young controls. |
This is a weak advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Advising clinicians on the respiratory presentations of EV-D68 and alerting them to known active circulation will help improve current under-ascertainment and consistency of recording. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The model here does not explicitly contain such a parameter, but the pruning effect emerges naturally based on the fact that the value of uncertainty resolution is lower for the branches of the model that start with large punishments and therefore, they are more likely to be pruned. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | On the other hand, the increased tooth size discrepancy of anterior ratio in our sample supports the finding of other studies, such as Crosby and Alexander,34 Freeman et al,35 Santoro et al,36 Bernabé et al,37 O’Mahony et al,30 and Araujo and Souki,38 which found that the percentage of tooth size discrepancy in anterior ratio was more than the overall ratio (17.5% to 37.9% anterior ratio, 5.4% to 13.5% overall ratio). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | No matter what protocol adopt, low oxygen cultivation indeed optimize patients’ treatment outcomes to some extent. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Despite this potential overestimation of impairment when object knowledge is assessed by verbal responses, the percentage of anomias associated with word definition (i.e. comprehension) failures was significantly higher than the percentage associated with object definition failures. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Such isolated emergence of anomia in patients with atrophy confined to the anterior tip of the left temporal lobe has been reported previously and found to represent a prodromal stage of semantic PPA in some, but not all, cases (Czarnecki et al, 2008; Mesulam et al, 2012). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, as a prospective study, the sample size of this study was relatively small, and further studies are needed. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Our clinical observations demonstrate that increased glomerular TNF expression in patients with FSGS correlates with reduced eGFR in the NEPTUNE cohort (Figure 3D) and with reduced ABCA1 expression in the ERCB cohort (Supplemental Figure 9), suggesting a role of local TNF in the pathogenesis of glomerular diseases. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In this study, breast cancer awareness was significantly associated with higher education and income levels. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | These correlations are consistent with a recent study on infants and young children investigating relationships between white matter myelination and early learning composite as well as verbal and nonverbal developmental quotients (8). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Indeed, while psychological distress can be inherent to being transsexual, it could also be socially induced by the society, peers and family2. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Training time needed for personnel to use the instrument was reasonable and the screening was well tolerated by pre-school children. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Despite being well-powered to confirm the majority of true associations, and identifying GSVs at similar overall frequencies to the original reports, only one reported association was confirmed using a case-control approach. |
This is a weak advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The hitherto aldosterone-to-renin ratio (ARR) is insisted to be a more valuable test than aldosterone levels for primary aldosteronism, and it could be an index for inappropriate aldosterone activity and salt sensitivity. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The proportion of asymptomatic relatives with reduced total IgG, IgM and/or IgA in the Iranian (13%) and Turkish (19%) cohorts was comparable to that in our cohort (8/47, 17%) 42,43. |
This is a strong advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Whether a goal of reduction only (example not in preparation for abstinence) should be accepted as a primary treatment goal among cannabis users is debatable (Lozano, Stephens, & Roffman, 2006). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, even in this initial step, MPI poor adults took longer than non-poor adults to seek help (with equivalent delays among poor and non-poor children). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Somewhat disappointingly, however, despite ongoing participating center guidance and encouragement to enroll, only a minority of searches were included in the trial. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | A delay of 2 months occurred between the dates when employees were probably exposed to C. burnetii and when environmental dust samples were collected. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | These scales can be considered neurotic-like, raising the question of whether MtFs are more neurotic than FtMs, because of stigma39. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Accordingly, genetic analysis of heritable quantitative endophenotypes such as cognitive function that are often considered as intermediates in the causal chain leading from risk allele to clinical disease may help to uncover loci that increase or reduce susceptibility to dementia in its preclinical phase [Bennett et al 2009; Carmelli et al 2002; Gottesman and Gould 2003; McClearn et al 1997; Shulman et al 2010; Swan et al 1990]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Our institutional experience also reflects the concept of multimodal pharmacological and nonpharmacological therapies. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In addition, the common SNPs analyzed in this study may not be the causal variant even in individuals of European descent, and differences in linkage disequilibrium and allele frequency between whites and African-Americans could also result in variation in the ability to detect associations in non-European individuals as well as in the direction of effect. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Alterations in jejunal mucosal TJ signaling have been described in IBS-D, but the relationship with HLA-DQ status was not previously investigated (25). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Low oxygen cultivation had more embryos available for cryopreservation, providing patients with more opportunities for achieving pregnancy in subsequent cycles, and thus optimizing the treatment outcomes. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In SF, angiogenin was found in a wide range of concentrations. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Thus, it is unclear if multiple introductions occurred, or if unknown carriers or contaminated environmental sources could link the spread between patients from these two PO10s. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | It may be useful, in future, to explore the effects of our short duration stress paradigm on more complex assessments of cognitive function then the tests employed here and in our companion paper. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | To our knowledge, this is the first study to examine the association between stress and severity of atopic dermatitis in an Asian population using national survey data. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The plasma homocystein levels is increas in arthritis [29]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In summary, the current results with cannabis users trying to change are very similar to those of our prior study of daily cannabis users (Hughes et al, 2008) and our prior studies of tobacco smokers using the same methodology (Hughes JR et al, 2014c; Peters & Hughes, 2009; Hughes et al, 2013). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In particular, Ronco et al. [16] proposed that plasma NGAL may be useful in the diagnosis and prevention of CRS if a curve of plasma values rather than a single plasma measurement is determined. |