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The Climate in the European Union and the Enlarged European Region is a Determinant of the COVID-19 Case Fatality Ratio | Climate could influence the COVID-19 pandemic, but while no evidence has been advanced on the influence of colder climates, some studies have provided data to support a possible heat-related protective factor The objective is to verify whether areas with a Cold Temperate Climate (TC) have a higher Case Fatality Ratio (CFR) for COVID-19 than areas with a Cold Climate (CC) or with a Mediterranean Climate (MC) in the European Union and the Enlarged European Region Countries or regions were subdivided into 3 groups according to the Koppen climate classification system: TC (Cfa, Cfb and Cfc in the Koppen system);MC (Csa, Csb);CC (D and E in the Koppen system) The total number of cases and the total number of deaths were detected on 13 August 2020 on the COVID-19 Map-Johns Hopkins Coronavirus Resource Center-the CFR was thus calculated by area Living in TC areas is strongly associated with risk of a high Case Fatality Ratio for COVID-19, OR for MC=0 42, IC 95% 0 41-0 43;OR for CC=0 33, IC 95% 0 33-0 35 The results are confirmed in the EU, OR per MC=0 85, CI 95% 0 84-0 87;OR per CC=0 63, IC 95% 0 61-0 65 The study found that the IC in a humid temperate climate is associated with higher CFR with respect to the coldest and warmest temperate climates in Europe This does not appear to be the only determinant of the pandemic | Please summerize the given abstract to a title |
Using the hierarchy of control technologies to improve healthcare facility infection control: lessons from severe acute respiratory syndrome. | Health care facilities need to review their infection control plans to prepare for the possible resurgence of severe acute respiratory syndrome, other emerging pathogens, familiar infectious agents such as tuberculosis and influenza, and bioterrorist threats. This article describes the classic "hierarchy of control technologies" that was successfully used by occupational and environmental medicine professionals to protect workers from illness and death during the resurgence of tuberculosis in the 1990s. Also discussed are related guidelines from building and equipment professional organizations and novel infection control techniques used successfully by various hospitals in Asia, Canada, and the United States during the 2003 severe acute respiratory syndrome epidemic. Taken together, they suggest a framework upon which a comprehensive infection control plan can be crafted to prevent the spread of deadly infectious agents to health care workers (clinicians and paraprofessionals), uninfected patients and visitors. | Please summerize the given abstract to a title |
Clearing the Smoke Screen: Smoking, Alcohol Consumption, and Stress Management Techniques among Canadian Long-Term Care Workers | BACKGROUND: Currently, there is abundant research indicating that smoking and alcohol consumption have significant impacts on morbidity and mortality, though little is known about these behaviors among Canadian health care workers. The objective of this study was to examine health and coping behaviors, such as smoking and alcohol consumption as well as stress management techniques, among health care workers consisting of gendered, racialized, and immigrant employees. METHODS: Drawing on a single-case, mixed-methods study in Ontario, Canada, this paper presents under-researched data about smoking practices, alcohol consumption, and stress management techniques among health care workers in labor-intensive, high-stress, high-turnover environments. In particular, it identifies the various mechanisms for maintaining health and well-being. RESULTS: The findings suggest that 7.7% of survey respondents reported smoking while 43.4% reported alcohol consumption, which were reported more frequently among immigrants than among non-immigrants. Participants also reported health-promoting activities in face-to-face interviews, such as mindful breathing techniques and drawing upon social support, while a few respondents reported alcohol consumption to specifically cope with sleep disturbances and job stress. CONCLUSIONS: Although smoking and alcohol consumption were both connected with coping strategies and leisure, they were predominant in immigrant groups compared to non-immigrant groups. | Please summerize the given abstract to a title |
Ultrasonographic Evaluation of Three Approaches for Botulinum Toxin Injection into Tibialis Posterior Muscle in Chronic Stroke Patients with Equinovarus Foot: An Observational Study | Spastic equinovarus (SEV) foot deformity is commonly observed in patients with post-stroke spasticity. Tibialis posterior (TP) is a common target for botulinum toxin type-A (BoNT-A) injection, as a first-line treatment in non-fixed SEV deformity. For this deep muscle, ultrasonographic guidance is crucial to achieving maximum accuracy for the BoNT-A injection. In current clinical practice, there are three approaches to target the TP: an anterior, a posteromedial, and a posterior. To date, previous studies have failed to identify the best approach for needle insertion into TP. To explore the ultrasonographic characteristics of these approaches, we investigated affected and unaffected legs of 25 stroke patients with SEV treated with BoNT-A. We evaluated the qualitative (echo intensity) and quantitative (muscle depth, muscle thickness, overlying muscle, subcutaneous tissue, cross-sectional area) ultrasound characteristics of the three approaches for TP injection. In our sample, we observed significant differences among almost all the parameters of the three approaches, except for the safety window. Moreover, our analysis showed significant differences in cross-sectional area between treated and untreated. Advantages and disadvantages of each approach were investigated. Our findings can thus provide a suitable reference for clinical settings, especially for novice operators. | Please summerize the given abstract to a title |
Punctuating the equilibrium: an application of policy theory to COVID-19 | COVID-19 has taught us that, when inadequately addressed, preexisting policy problems (e.g. weak coordination of healthcare and gaps in income supports) exacerbate the cost of crises (including deaths) and make policy responses more difficult. On a more hopeful note, the pandemic has also revealed that policymakers and bureaucrats, reputed as defenders of the status quo and glacially paced, are capable of moving nimbly when seized with necessity. This manuscript draws on Baumgartner and Jones' punctuated-equilibrium theory to analyze and demonstrate how policy responses to the pandemic, largely in Canada but also globally, were shaped by preexisting problems (periods of equilibrium). It then raises the question: Will future policy reflect lessons learned through COVID-19, to not only mitigate risks from further crises, but also tackle many other policy challenges? It would seem we can no longer accept the excuse that problems are too complex or time-consuming to tackle. | Please summerize the given abstract to a title |
Understanding Knowledgeable Workers’ Behavior Toward COVID-19 Information Sharing Through WhatsApp in Pakistan | Using social media through mobile has become a major source of disseminating information; however, the motivations that impact social media users’ intention and actual information-sharing behavior need further examination. To this backdrop, drawing on the uses and gratifications theory, theory of prosocial behavior, and theory of planned behavior, we aim to examine various motivations toward information-sharing behaviors in a specific context [coronavirus disease 2019 (COVID-19)]. We collected data from 388 knowledgeable workers through Google Forms and applied structural equation modeling to test the hypotheses. We noted that individuals behave seriously toward crisis-related information, as they share COVID-19 information on WhatsApp not only to be entertained and seek status or information but also to help others. Further, we noted norms of reciprocation, habitual diversion, and socialization as motivators that augment WhatsApp users’ positive attitude toward COVID-19 information-sharing behavior. | Please summerize the given abstract to a title |
Effects of virtual learning environments: A scoping review of literature | The purpose of this scoping review is to isolate and investigate the existing data and research that identifies if the synchronous face-to-face visual presence of a teacher in a virtual learning environment (VLE) is a significant factor in a student’s ability to maintain good mental health. While the present research on this explicit interaction among VLE implementation and student mental health is limited, the material suggests a framework for strong utilization of VLEs. Overall, our research has shown that authentic, high quality VLEs are ones that have as their primary focus the communication between students and their teachers and between students and their peers. This communication is best generated through synchronous connections where there exists the ability to convey the student’s immediate needs in real-time. Our research results and discussion will outline how a team approach that brings together teachers, students, administration, counsellors, mental health support staff, instructional designers, and ICT specialists is necessary to create a genuinely enriching VLE where both learning and social-emotional needs can be met. The authors present a case for further study in order to reveal the nature of the interaction among VLEs and student mental health. | Please summerize the given abstract to a title |
Partnering with Agents: How the Covid‐19 Pandemic changed Relations between the UK Government and Public Service Contractors | The contracting out of public goods and services has become a central feature of the UK's state machinery, with more than £350 billion spent annually on services ranging from rubbish collection to building submarines. In response to the Covid‐19 pandemic, the UK government took the unprecedented step of incorporating private providers at a national scale to deliver emergency services which were previously the purview of the state. To achieve this, the government used emergency legislation temporarily to remove competitive tenders and reduced reporting processes. In doing so, it substantially re‐orientated its relationship with private providers, moving from a position of a principal granting its authority to deliver services to something more akin to a partner organisation leveraging private resources. This shift in power dynamics, coupled with an ongoing government ambition to expand the UK's public service markets, risks a permanent change in government‐provider relations, to the detriment of the UK's contracting out framework. | Please summerize the given abstract to a title |
Willingness of lay people to perform resuscitation during a pandemic crisis of Covid-19 disease | Introduction: The pandemic crisis of Covid-19 disease caused by novel coronavirus SARS-CoV-2 was associated with increased fear of infection among majority of population This retrospective observation aim to find out if the presence of augmented feeling of infectious disease transmission risk affect the willingness of lay people to provide resuscitation (CPR), which is considered to be an aerosol-generating procedure with high COVID-transmission risk 1,2 Methods: Retrospective analysis of the registry of the cardiac arrests in the capital city of the Czech Republic, which were dealt with by Prague Emergency Medical Services (EMS) during COVID-19 outbreak period (March and April 2020), compared to the same period of the year 2019 All EMS-resuscitated patients with pre-EMS-arrival out-of-hospital cardiac arrest (CA) were included Results: During the study periods, Prague EMS dealt with 74 CA in 2019 compared to 75 CA in 2020, respectively In 2019, Lay CPR was provided in 63 cases (85%), in 2020 in 65 cases (86%);p > 0 05 Mouth-to-mouth ventilation was provided in 4 cases in 2019 and 3 cases in 2020 (p > 0 05) Primary outcome (return of spontaneous circulation in the out-of-hospital environment) was achieved in 37 (2019) vs 32 (2020) cases (p > 0 05) We were also not informed about any case of non-willingness to provide layperson CPR, as happened in Australia 3 Conclusion: Willingness of lay people in the city of Prague to provide CPR was not affected by the pandemic situation in general The primary outcome was also not affected Despite the fact that reasons for this were not surveyed, the effect of telephone assisted CPR is playing a crucial role during the last decades 4 | Please summerize the given abstract to a title |
WHO Report: COVID-19 Was a Preventable Disaster | Failures in preparation and response led to a worsened crisis. | Please summerize the given abstract to a title |
Embedded Bilateralism, Integration Theory, and European Crisis Politics: France, Germany, and the Birth of the EU Corona Recovery Fund* | What explains the creation of the EU corona recovery fund? Why did the Union agree on a large-scale financial response to the corona pandemic, despite member states' very different immediate reactions to the crisis and their opposing attitudes towards common debt? This article argues for the decisiveness of France and Germany's role within the Union and their tight bilateral political cooperation. The ‘embedded bilateralism’ approach to European integration and EU politics explains how and why France and Germany, starting from different poles, came together and established joint positions, paving the way for an overall European compromise. Focusing on these two countries' particular leadership role advances the theoretical debate about the actors most crucial for driving European integration, especially in times of severe crisis. © 2021 The Authors. JCMS: Journal of Common Market Studies published by University Association for Contemporary European Studies and John Wiley & Sons Ltd. | Please summerize the given abstract to a title |
Colorectal Cancer: In the Pursuit of Health Equity | Colorectal cancer mortality has decreased considerably following the adoption of national screening programs, yet, within at-risk subgroups, there continue to be measurable differences in clinical outcomes from variations in screening, receipt of chemotherapy, radiation or surgery, access to clinical trials, research participation, and survivorship. These disparities are well-described and some have worsened over time. Disparities identified have included race and ethnicity, age (specifically young adults), socioeconomic status, insurance access, geography, and environmental exposures. In the context of the COVID-19 pandemic, colorectal cancer care has necessarily shifted dramatically, with broad, immediate uptake of telemedicine, transition to oral medications when feasible, and considerations for sequence of treatment. However, it has additionally marginalized patients with colorectal cancer with historically disparate cancer-specific outcomes; among them, uninsured, low-income, immigrant, and ethnic-minority patients-all of whom are more likely to become infected, be hospitalized, and die of either COVID-19 or colorectal cancer. Herein, we outline measurable disparities, review implemented solutions, and define strategies toward ensuring that all have a fair and just opportunity to be as healthy as possible. | Please summerize the given abstract to a title |
Detection of Viral RNA Fragments in Human iPSC-Cardiomyocytes following Treatment with Extracellular Vesicles from SARS-CoV-2 Coding-Sequence-Overexpressing Lung Epithelial Cells | The novel coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved into a worldwide pandemic. Early data suggest that the prevalence and severity of COVID-19 appear to be higher among patients with underlying cardiovascular risk factors. Despite the expression of angiotensin-converting enzyme 2 (ACE2), a functional receptor for SARS-CoV-2 infection, in cardiomyocytes, there has been no conclusive evidence of direct viral infection although the presence of inflammation and viral genome within the hearts of COVID-19 patients have been reported. Here we transduced A549 lung epithelial cells with lentivirus overexpressing selected genes of the SARS-CoV-2. We then isolated extracellular vesicles (EVs) from the supernatant of A549 cells and detected the presence of viral RNA within the purified EVs. Importantly, we observed that human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) were able to actively uptake these EVs and viral genes were subsequently detected in the cardiomyocytes. Accordingly, uptake of EVs containing viral genes led to an upregulation of inflammation-related genes in hiPSC-CMs. Thus, our findings indicate that SARS-CoV-2 RNA-containing EVs represent an indirect route of viral RNA entry into cardiomyocytes. | Please summerize the given abstract to a title |
Auxetic Metamaterials for Biomedical Devices: Current Situation, Main Challenges, and Research Trends | Auxetic metamaterials are characterized by a negative Poisson ratio (NPR) and display an unexpected property of lateral expansion when stretched and densification when compressed. Auxetic properties can be achieved by designing special microstructures, hence their classification as metamaterials, and can be manufactured with varied raw materials and methods. Since work in this field began, auxetics have been considered for different biomedical applications, as some biological tissues have auxetic-like behaviour due to their lightweight structure and morphing properties, which makes auxetics ideal for interacting with the human body. This research study is developed with the aim of presenting an updated overview of auxetic metamaterials for biomedical devices. It stands out for providing a comprehensive view of medical applications for auxetics, including a focus on prosthetics, orthotics, ergonomic appliances, performance enhancement devices, in vitro medical devices for interacting with cells, and advanced medicinal clinical products, especially tissue engineering scaffolds with living cells. Innovative design and simulation approaches for the engineering of auxetic-based products are covered, and the relevant manufacturing technologies for prototyping and producing auxetics are analysed, taking into consideration those capable of processing biomaterials and enabling multi-scale and multi-material auxetics. An engineering design rational for auxetics-based medical devices is presented with integrative purposes. Finally, key research, development and expected technological breakthroughs are discussed. | Please summerize the given abstract to a title |
Financial Stress in Emerging Adults with Type 1 Diabetes in the United States. | OBJECTIVE To describe the relationships among financial stress factors (perceived stress, financial stress, and financial independence) and psychological factors (depressive symptoms, trait anxiety, and diabetes distress) on self-management outcomes (HbA1c and diabetes-related quality of life) in emerging adults with type 1 diabetes. RESEARCH DESIGN AND METHODS A descriptive, correlational, cross-sectional study examined413 emerging adults, ages 18-25, from the Type 1 Diabetes Exchange Clinic Registry. Data were collected viaREDCap surveys using the Personal Financial Well-Being Scale, Willingness to Pay Scale, Financial Independence Visual Analog Scale, Center for Epidemiological Studies-Depression Inventory, State-Trait Anxiety Inventory, The Type 1 Diabetes Distress Scale, and Diabetes Quality of Life Measure. Hierarchical Multiple Regression analyses explored significant barriers to self-management outcomes. RESULTS Hierarchical Multiple Regression analyses revealed that 20.6% of variance in HbA1c (F=15.555, p<.001) was explained by greater financial stress (β=-.197, p<.001), willingness to pay (β=-.220, p < .001), disease duration (β = .119, p = .014), and diabetes distress (β=.181, p<.001); 64.5% of the variance in diabetes-related quality of life (F=148.469, p<.001) wassignificantly explained by greater financial stress (β=-.112, p = .002), diabetes distress (β=.512, p<.001), trait anxiety (β=.183, p=.001) and depressive symptoms (β=.162, p=.001). CONCLUSIONS Greater financial stress and psychological factors have detrimental impacts on self-management outcomes during emerging adulthood. Diabetes providers need to identify and address these factors in routine care and advocate for policy changes to support improved self-management outcomes. This article is protected by copyright. All rights reserved. | Please summerize the given abstract to a title |
The CRISPR-Cas toolbox for analytical and diagnostic assay development. | Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and CRISPR-associated (Cas) systems have revolutionized biological and biomedical sciences in many ways. The last few years have also seen tremendous interest in deploying the CRISPR-Cas toolbox for analytical and diagnostic assay development because CRISPR-Cas is one of the most powerful classes of molecular machineries for the recognition and manipulation of nucleic acids. In the short period of development, many CRISPR-enabled assays have already established critical roles in clinical diagnostics, biosensing, and bioimaging. We describe in this review the recent advances and design principles of CRISPR mediated analytical tools with an emphasis on the functional roles of CRISPR-Cas machineries as highly efficient binders and molecular scissors. We highlight the diverse engineering approaches for molecularly modifying CRISPR-Cas machineries and for devising better readout platforms. We discuss the potential roles of these new approaches and platforms in enhancing assay sensitivity, specificity, multiplexity, and clinical outcomes. By illustrating the biochemical and analytical processes, we hope this review will help guide the best use of the CRISPR-Cas toolbox in detecting, quantifying and imaging biologically and clinically important molecules and inspire new ideas, technological advances and engineering strategies for addressing real-world challenges such as the on-going COVID-19 pandemic. | Please summerize the given abstract to a title |
The emerging role of perivascular cells (pericytes) in viral pathogenesis | Viruses may exploit the cardiovascular system to facilitate transmission or within-host dissemination, and the symptoms of many viral diseases stem at least in part from a loss of vascular integrity. The microvascular architecture is comprised of an endothelial cell barrier ensheathed by perivascular cells (pericytes). Pericytes are antigen-presenting cells (APCs) and play crucial roles in angiogenesis and the maintenance of microvascular integrity through complex reciprocal contact-mediated and paracrine crosstalk with endothelial cells. We here review the emerging ways that viruses interact with pericytes and pay consideration to how these interactions influence microvascular function and viral pathogenesis. Major outcomes of virus-pericyte interactions include vascular leakage or haemorrhage, organ tropism facilitated by barrier disruption, including viral penetration of the blood-brain barrier and placenta, as well as inflammatory, neurological, cognitive and developmental sequelae. The underlying pathogenic mechanisms may include direct infection of pericytes, pericyte modulation by secreted viral gene products and/or the dysregulation of paracrine signalling from or to pericytes. Viruses we cover include the herpesvirus human cytomegalovirus (HCMV, Human betaherpesvirus 5), the retrovirus human immunodeficiency virus (HIV; causative agent of acquired immunodeficiency syndrome, AIDS, and HIV-associated neurocognitive disorder, HAND), the flaviviruses dengue virus (DENV), Japanese encephalitis virus (JEV) and Zika virus (ZIKV), and the coronavirus severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2; causative agent of coronavirus disease 2019, COVID-19). We touch on promising pericyte-focussed therapies for treating the diseases caused by these important human pathogens, many of which are emerging viruses or are causing new or long-standing global pandemics. | Please summerize the given abstract to a title |
Protect Against Unintentional Insider Threats: The risk of an employee's cyber misconduct on a Social Media Site | Social Media is a cyber-security risk for every business. What do people share on the Internet? Almost everything about oneself is shared: friendship, demographics, family, activities, and work-related information. This could become a potential risk in every business if the organization's policies, training and technology fail to properly address these issues. In many cases, it is the employees' behaviour that can put key company information at danger. Social media has turned into a reconnaissance tool for malicious actors and users accounts are now seen as a goldmine for cyber criminals. Investigation of Social Media is in the embryonic stage and thus, is not yet well understood. This research project aims to collect and analyse open-source data from LinkedIn, discover data leakage and analyse personality types through software as a service (SAAS). The final aim of the study is to understand if there are behavioral factors that can predicting one's attitude toward disclosing sensitive data. | Please summerize the given abstract to a title |
How Will the Future of Work Shape the OSH Professional of the Future? A Workshop Summary | Rapid and profound changes anticipated in the future of work will have significant implications for the education and training of occupational safety and health (OSH) professionals and the workforce. As the nature of the workplace, work, and the workforce change, the OSH field must expand its focus to include existing and new hazards (some yet unknown), consider how to protect the health and well-being of a diverse workforce, and understand and mitigate the safety implications of new work arrangements. Preparing for these changes is critical to developing proactive systems that can protect workers, prevent injury and illness, and promote worker well-being. An in-person workshop held on February 3–4, 2020 at The University of Texas Health Science Center (UTHealth) School of Public Health in Houston, Texas, USA, examined some of the challenges and opportunities OSH education will face in both academic and industry settings. The onslaught of the COVID-19 global pandemic reached the United States one month after this workshop and greatly accelerated the pace of change. This article summarizes presentations from national experts and thought leaders across the spectrum of OSH and professionals in the fields of strategic foresight, systems thinking, and industry, and provides recommendations for the field. | Please summerize the given abstract to a title |
Posttraumatic stress symptoms and associated comorbidity during the COVID-19 pandemic in Ireland: A population based study | The prevalence of posttraumatic stress disorder (PTSD) as it relates to people’s experiences of the COVID-19 pandemic has yet to determined. This study was conducted to determine rates of COVID-19 related PTSD in the Irish general population, the level of comorbidity with depression and anxiety, and sociodemographic risk factors associated with COVID-19 related PTSD. A nationally representative sample of adults from the general population of the Republic of Ireland (N = 1,041) completed self-report measures of all study variables. The rate of COVID-19 related PTSD was 17.7% (95% CI = 15.35 - 19.99%: n=184), and comorbidity with generalized anxiety (49.5%) and depression (53.8%) was high. Meeting the diagnostic requirement for COVID-19 related PTSD was associated with younger age, male sex, living in a city, living with children, moderate and high perceived risk of COVID-19 infection, and screening positive for anxiety or depression. Traumatic stress problems related to the COVID-19 pandemic are common in the general population. Our results show that health professionals responsible for responding to the COVID-19 pandemic should expect to routinely encounter traumatic stress problems. | Please summerize the given abstract to a title |
Effects of COVID-19 Pandemic on Children, Adolescents and Young Adults with Asthma in Rhode Island: Patterns in Emergency Department Utilization with Geospatial Mapping | In Rhode Island, asthma-related emergency department utilization significantly decreased during the first ten months of the COVID-19 pandemic (1/1/20-10/31/20) compared to previous years. ED utilization rates remained highest in high-risk, urban communities also most affected by COVID-19, highlighting the need for future research and intervention aimed at supporting high-risk, urban youth and young adults with asthma. | Please summerize the given abstract to a title |
COVID-19 and traumatic stress: The role of perceived vulnerability, COVID-19-related worries, and social isolation | The purpose of the present study was to propose and test two models to understand the relationship between perceived vulnerability to COVID-19 (PVC) and COVID-19-related traumatic stress (TS), as well as the variables that may mediate and moderate this relationship among individuals who have not yet been infected with COVID-19. Using an online survey, data were collected between late March and early April 2020. Participants were recruited through Amazon Mechanical Turk and included 747 adults living in the United States. Supporting our hypotheses, results indicated that both COVID-19-related worries and social isolation were significant mediators of the relationship between PVC and TS (Model 1). In addition, the results of a moderated mediation analysis indicated that the indirect effect of PVC on TS through COVID-19-related worries was stronger for participants who reported greater social isolation (Model 2). Although future research is needed, these findings suggest that both social isolation and disease-related worries may be important variables that can be targeted in interventions to reduce pandemic-related TS. | Please summerize the given abstract to a title |
Architectural design strategies for infection prevention and control (IPC) in health-care facilities: towards curbing the spread of Covid-19 | Background: Sustainable design strategies are targeted at finding architectural solutions that reassure the well-being and coexistence of inorganic features, living organisms, and humans that make up the ecosystem. The emergence of the novel coronavirus, an increase in microbial resistance, and lack of a vaccine for the present pandemic have made it imperative to appraise the preventive strategies employed during the pre-antibiotic period. Sustainable architecture for children's hospital design and childcare facilities, apart from low energy and carbon emission, must integrate design strategies to confront the impact of infectious diseases. Aim: The aim of the paper is to identify how the space patients and health-care workers0 occupy can be made safer from an architectural design perspective with the view of developing guidelines for policymakers and highlighting the architect's role in combating the pandemic. Objectives: The objectives include; to examine the evolution of medical architecture and the nexus between infectious diseases and architectural space and suggest a design approach that enhances infection prevention and control (IPC). Method: The paper relied on existing literature, interviews, and interactions with healthcare workers. Results/Conclusion: The findings showed that design strategies have always played a significant role in infection prevention and control (IPC) and could as well be a panacea for curbing the spread of Covid -19. | Please summerize the given abstract to a title |
Bactrian camels shed large quantities of Middle East respiratory syndrome coronavirus (MERS-CoV) after experimental infection | In 2012, Middle East respiratory syndrome coronavirus (MERS-CoV) emerged. To date, more than 2300 cases have been reported, with an approximate case fatality rate of 35%. Epidemiological investigations identified dromedary camels as the source of MERS-CoV zoonotic transmission and evidence of MERS-CoV circulation has been observed throughout the original range of distribution. Other new-world camelids, alpacas and llamas, are also susceptible to MERS-CoV infection. Currently, it is unknown whether Bactrian camels are susceptible to infection. The distribution of Bactrian camels overlaps partly with that of the dromedary camel in west and central Asia. The receptor for MERS-CoV, DPP4, of the Bactrian camel was 98.3% identical to the dromedary camel DPP4, and 100% identical for the 14 residues which interact with the MERS-CoV spike receptor. Upon intranasal inoculation with 107 plaque-forming units of MERS-CoV, animals developed a transient, primarily upper respiratory tract infection. Clinical signs of the MERS-CoV infection were benign, but shedding of large quantities of MERS-CoV from the URT was observed. These data are similar to infections reported with dromedary camel infections and indicate that Bactrians are susceptible to MERS-CoV and given their overlapping range are at risk of introduction and establishment of MERS-CoV within the Bactrian camel populations. | Please summerize the given abstract to a title |
Prevalence and incidence of anti-SARS-CoV-2 antibodies among healthcare workers in Belgian hospitals before vaccination: a prospective cohort study | OBJECTIVES: To describe prevalence and incidence of anti-SARS-CoV-2 antibodies among Belgian hospital healthcare workers (HCW) in April–December 2020. DESIGN: Prospective cohort study. Follow-up was originally planned until September and later extended. SETTING: Multicentre study, 17 hospitals. PARTICIPANTS: 50 HCW were randomly selected per hospital. HCW employed beyond the end of the study and whose profession involved contact with patients were eligible. 850 HCW entered the study in April–May 2020, 673 HCW (79%) attended the September visit and 308 (36%) the December visit. OUTCOME MEASURES: A semiquantitative ELISA was used to detect IgG against SARS-CoV-2 in serum (Euroimmun) at 10 time points. In seropositive samples, neutralising antibodies were measured using a virus neutralisation test. Real-time reverse transcription PCR (RT-qPCR) was performed to detect SARS-CoV-2 on nasopharyngeal swabs. Participant characteristics and the presence of symptoms were collected via an online questionnaire. RESULTS: Among all participants, 80% were women, 60% nurses and 21% physicians. Median age was 40 years. The seroprevalence remained relatively stable from April (7.7% (95% CI: 4.8% to 12.1%) to September (8.2% (95% CI: 5.7% to 11.6%)) and increased thereafter, reaching 19.7% (95% CI: 12.0% to 30.6%) in December 2020. 76 of 778 initially seronegative participants seroconverted during the follow-up (incidence: 205/1000 person-years). Among all seropositive individuals, 118/148 (80%) had a positive neutralisation test, 83/147 (56%) presented or reported a positive RT-qPCR, and 130/147 (88%) reported COVID-19-compatible symptoms at least once. However, only 46/73 (63%) of the seroconverters presented COVID-19-compatible symptoms in the month prior to seroconversion. CONCLUSIONS: The seroprevalence among hospital HCW was slightly higher than that of the general Belgian population but followed a similar evolution, suggesting that infection prevention and control measures were effective and should be strictly maintained. After two SARS-CoV-2 waves, 80% of HCW remained seronegative, justifying their prioritisation in the vaccination strategy. TRIAL REGISTRATION NUMBER: NCT04373889 | Please summerize the given abstract to a title |
Development of the 12-Item Social Media Disinformation Scale and its Association With Social Media Addiction and Mental Health Related to COVID-19 in Tunisia: Survey-Based Pilot Case Study | BACKGROUND: In recent years, online disinformation has increased. Fake news has been spreading about the COVID-19 pandemic. Since January 2020, the culprits and antidotes to disinformation have been digital media and social media. OBJECTIVE: Our study aimed to develop and test the psychometric properties of the 12-item Social Media Disinformation Scale (SMDS-12), which assesses the consumption, confidence, and sharing of information related to COVID-19 by social media users. METHODS: A total of 874 subjects were recruited over two phases: the exploratory phase group had a mean age of 28.39 years (SD 9.32) and the confirmatory phase group had a mean age of 32.84 years (SD 12.72). Participants completed the SMDS-12, the Internet Addiction Test, the COVID-19 Fear Scale, and the 10-item Perceived Stress Scale. The SMDS-12 was initially tested by exploratory factor analysis and was subsequently tested by confirmatory factor analysis. RESULTS: The test supported the three-factor structure. In addition, no items were removed from the measurement scale, with three factors explaining up to 73.72% of the total variance, and the items had a lambda factor loading ranging from 0.73 to 0.85. Subsequently, confirmatory factor analysis confirmed the robustness of the measure by referring to a wide range of goodness-of-fit indices that met the recommended standards. The construct validity of the scale was supported by its convergent and discriminant validity. The reliability of the instrument examined by means of three internal consistency indices, and the corrected item-total correlation, demonstrated that the three dimensions of the instrument were reliable: Cronbach α values were .89, .88, and .88 for the consumption, confidence, and sharing subscales, respectively. The corrected item-total correlation ranged from 0.70 to 0.78. The correlation of the instrument’s dimensions with internet addiction and mental health factors showed positive associations. CONCLUSIONS: The SMDS-12 can be reliably utilized to measure the credibility of social media disinformation and can be adapted to measure the credibility of disinformation in other contexts. | Please summerize the given abstract to a title |
Perceived Discrimination and Psychological Distress: A Survey of Filipinx Americans in Massachusetts during the COVID-19 Pandemic | The onset of the COVID-19 pandemic has led to an upsurge of discrimination against Asian American populations, and Filipinx Americans (FA) have reported high cases of perceived discrimination. Prior studies have shown a relationship between experiences of discrimination and poor mental health. The purpose of this study was to examine the association of perceived discrimination and psychological distress among FA living in Massachusetts from a survey collected during the COVID-19 pandemic (N = 133). Multiple regression analysis revealed that experiences of perceived discrimination were associated with psychological distress. Older participants were less likely to report psychological distress. Compared to men, womxn were more likely to report psychological distress. Our findings highlight the potential mental health consequences of perceived discrimination experienced by FA, which may have been exacerbated during the COVID-19 pandemic. | Please summerize the given abstract to a title |
A look at the global impact of SARS CoV-2 on orthopedic services | BACKGROUND: The COVID-19 pandemic profoundly impacted healthcare institutions worldwide. Particularly, orthopedic departments had to adapt their operational models. PURPOSE: This review aimed to quantify the reduction in surgical and outpatient caseloads, identify other significant trends and ascertain the impact of these trends on orthopedic residency training programs. METHODS: Medline and Embase were searched for articles describing case load for surgeries, outpatient clinic attendance, or emergency department (ED) visits. Statistical analysis of quantitative data was performed after a Freeman-Tukey double arcsine transformation. Results were pooled with random effects by DerSimonian and Laird model. When insufficient data was available, a systematic approach was used to present the results instead. RESULTS: A total of 23 studies were included in this study. The number of elective surgeries, trauma procedures and outpatient attendance decreased by 80% (2013/17400, 0.20, CI: 0.12 to 0.29), 47% (3887/17561, 0.53, CI: 0.37 to 0.69) and 63% (84174/123967, 0.37, CI: 0.24 to 0.51) respectively. During the pandemic, domestic injuries and polytrauma increased. Residency training was disrupted due to diminished clinical exposure and changing teaching methodologies. Additionally, residents had more duties which contributed to a lower quality of life. CONCLUSIONS: The COVID-19 pandemic has made an unprecedented impact on orthopedics departments worldwide. The slow return of orthopedic departments to normalcy and the compromised training of residents due to the pandemic points to an uncertain future for healthcare institutions worldwide, wherein the impact of this pandemic may yet still be felt far in the future. | Please summerize the given abstract to a title |
PREDICTORS AND OUTCOMES OF BACTERIAL AND FUNGAL SUPERINFECTIONS IN CRITICALLY ILL PATIENTS WITH COVID-19 | TOPIC: Chest Infections TYPE: Original Investigations PURPOSE: Secondary infections are well-described complications in patients with viral pneumonia and are associated with increased mortality and morbidity (1). A recent meta-analysis reported that secondary infections in critically ill Coronavirus Disease 19 (COVID-19) patients in intensive care unit (ICU) are around 14% (2). Most of the studies are limited by false-positive cultures in non-sterile body fluids (2). Our study aims to assess the burden of secondary infections by focusing on the positive rate of sterile body fluid cultures in ICU patients, to examine associated risk factors and to assess their impact on outcome. METHODS: Retrospective analysis of all adult patients with COVID-related acute respiratory distress syndrome (ARDS) admitted to the ICUs of a quaternary care hospital between 03/01/2020 and 05/31/2020. Patients who had positive sterile body fluid (blood, peritoneal, pleural or cerebrospinal fluid) cultures for bacteria or fungi, were compared with those without positive cultures. RESULTS: Of the 210 patients admitted to our ICU with COVID-19 related ARDS, 55 patients (26%) had positive sterile body fluid cultures, of which 37 grew bacteria, 7 fungi and 11 both. Patients with positive cultures were similar in terms of baseline demographics, comorbidities and severity of illness at ICU admission to those patients without positive cultures. Peak inflammatory markers were significantly higher in the positive culture group. In the positive culture group, the rates of receipt of steroids (78% vs. 61%, p=0.02) and convalescent plasma (64% vs. 45%, p=0.03) were significantly higher. The prevalence of acute kidney injury (AKI) requiring dialysis was significantly greater in the positive culture group (55% vs. 28%, p<0.001). There was no difference in terms of mortality between the two groups. However, mechanical ventilation (MV) free days at day 28 were significantly lower in the positive culture group (Mean ± S.D: 2.7 ± 5.7 vs. 6 ± 9.9, p=0.004). CONCLUSIONS: Our study shows that the incidence of superinfections in COVID-19 patients admitted to ICUs is higher than previously reported. The higher incidence is comparable to the rate of superinfections in the H1N1 influenza pandemic of 2009 (2). However, the high rates of steroid and plasma administration in our positive culture group may also have contributed to the high incidence of secondary infections. Our results have also shown that these infections may prolong ventilatory support as well as increase the likelihood of developing AKI requiring dialysis. Therefore, intensivists need to be vigilant about not missing superinfections in patients with COVID-19 which can negatively impact patient outcomes. CLINICAL IMPLICATIONS: This study will help to identify the risk factors associated with higher incidence of secondary infections in patients with COVID-19, and will assist physicians to identify and treat them early in the course of disease. 1. I. Martín-Loeches, A. Sanchez-Corral, E. Diaz, R.M. Granada, et al., H1N1 SEMICYUC Working Group Community-acquired respiratory coinfection in critically ill patients with pandemic 2009 influenza A(H1N1) virus. Chest, 139 (2011), pp. 555-562. 2. Lansbury L, Lim B, Baskaran V, Lim WS. Co-infections in people with COVID-19: a systematic review and meta-analysis. J Infect. 2020;81(2):266-275. DISCLOSURES: No relevant relationships by ALEENA ARSHAD, source=Web Response No relevant relationships by Dipak Chandy, source=Web Response No relevant relationships by Oleg Epelbaum, source=Web Response No relevant relationships by Daniel Greenberg, source=Web Response No relevant relationships by Muhammad Rizwan, source=Web Response No relevant relationships by Hamid Yaqoob, source=Web Response | Please summerize the given abstract to a title |
Optimization of an Inclusion Body-Based Production of the Influenza Virus Neuraminidase in Escherichia coli | Neuraminidase (NA), as an important protein of influenza virus, represents a promising target for the development of new antiviral agents for the treatment and prevention of influenza A and B. Bacterial host strain Escherichia coli BL21 (DE3)pLysS containing the NA gene of the H1N1 influenza virus produced this overexpressed enzyme in the insoluble fraction of cells in the form of inclusion bodies. The aim of this work was to investigate the effect of independent variables (propagation time, isopropyl β-d-1-thiogalactopyranoside (IPTG) concentration and expression time) on NA accumulation in inclusion bodies and to optimize these conditions by response surface methodology (RSM). The maximum yield of NA (112.97 ± 2.82 U/g) was achieved under optimal conditions, namely, a propagation time of 7.72 h, IPTG concentration of 1.82 mM and gene expression time of 7.35 h. This study demonstrated that bacterially expressed NA was enzymatically active. | Please summerize the given abstract to a title |
A technology enabled learning model in healthcare during covid-19 | The World Health Organization has warned about the spread of communicable and non-communicable diseases especially in the developing coun-tries The COVID–19 has also emerged as one of the most challengeable pandemics of the whole world In current medical emergency, the virtual health education is much vital for handling alerts and outbreaks of diseases for a community of users The Information and Communication Technology provide an opportunity to deal with the challenges related to handling alerts and outbreaks of diseases The technology infrastructure in the developing countries is surging rise and can be used to develop Technology Enabled Learning Solutions for the basic health issues This paper presents a technology model for virtual education of the masses during the recent era of pandemic diseases like COVID–19 The paper focuses on the health issues both in the developed and the developing coun-tries It also examines the technology options available for basic health education Based on the literature review, opinion of health professionals and survey results on ICT accessibility, this paper presents a model of virtual online education on basic health issues for a rural community of users A pragmatic approach (from literature) has been employed with constructivism theory in order to build the model We have restricted our study to the geographical location of District Swat, Khyber Pakhtunkhwa and suggested sampling level of basic health education to address the research problems A prototype with basic health education modules was also developed to demonstrate and test the model The feedback has been found encouraging to develop a complete basic health education portal © 2021, Tech Science Press All rights reserved | Please summerize the given abstract to a title |
A Matter of Trust? Political Trust and the COVID-19 Pandemic | There is significant cross-country variation in Covid-19 fatalities worldwide. In this study, we analyze the relationship between political trust and fatalities of the Covid-19 pandemic. By performing a cross-country analysis and controlling for other determinants, we find that government trust is negatively associated with Covid-19 cases and deaths. Additionally, our findings suggest that risk communication, in the form of public information campaigns, only decreased Covid-19 cases and deaths in countries with high trust in government. We also find evidence that political trust decreases the risk of removing lockdown policies. | Please summerize the given abstract to a title |
Emergency upscaling of video consultation during the COVID-19 pandemic: Contrasting user experience with data insights from the electronic health record in a large academic hospital | BACKGROUND: Video consultation (VC) has been scaled up at our academic centre attempting to facilitate and accommodate patient-provider interaction in times of social distancing during the recent and ongoing COVID-19 pandemic. OBJECTIVES: This study evaluates qualitative outcomes with data insights from the electronic health record, to contrast satisfaction outcomes with the actual use of VC. METHODS: Healthcare providers and patients using VC during the COVID-19 pandemic at a large academic centre in the Netherlands were surveyed for user satisfaction and experiences with VC. In addition, quantitative technical assessment was performed using data related to VC from the EHR record. RESULTS: In total, 1,027/4,443 patients and 87/166 healthcare providers completed their online questionnaire. Users rated the use of VC during a pandemic with an average score of 8.3/10 and 7.6/10 respectively. Both groups believed the use of VC was a good solution to continue the provision of healthcare during this pandemic. The use of VC increased from 92 in March 2020 to 837 in April 2020. CONCLUSION: This study strongly signals that VC is an important modality in futureproofing outpatient care during and beyond pandemic times. Further development in end-user technology is needed for EHR integrated VC solutions. Guidelines needs to be developed advising both patients and healthcare providers. Such guidelines should not solely focus on technical implementation and troubleshooting, but must also consider important aspects such as digital health literacy, patient and provider authentication, privacy and ethics. | Please summerize the given abstract to a title |
WHO's surveillance system for attacks on health care is failing Ethiopia | Considerations in boosting COVID-19 vaccine universal booster shots. We need to reach the washingtonpost.com/outlook/2021/11/29/ booster-shots-universal-opinion/ (accessed Jan 25, 2022). of COVID-19 vaccines. Jan 21, 2022. https:// www.who.int/publications/i/item/who-sageroadmap-for-prioritizing-uses-of-covid-19vaccines (accessed Jan 25, 2022). by COVID-19 vaccination status and previous COVID-19 diagnosis-California and New York, May-November 2021. MMWR Morb Mortal Wkly Rep 2022;71: 125-131 | Please summerize the given abstract to a title |
COVID-19 school and kindergarten closure relates to children's social relationships: a longitudinal study in Japan | The COVID-19 pandemic has led children to experience school closures. Although increasing evidence suggests that such intense social quarantine influences children’s social relationships with others, longitudinal studies are limited. Using longitudinal data collected during (T1) and after (T2) intensive school closure and home confinement, this study investigated the impacts of social quarantine on children’s social relationships. Japanese parents of children aged 0–9 years (n = 425) completed an online questionnaire that examined children’s socio-emotional behavior and perceived proximity to parents or others. The results demonstrated that social quarantine was not significantly related to children’s socio-emotional behavior across all age groups. However, changes in children’s perceived proximity varied depending on certain age-related factors: elementary schoolers’ perceived closeness to parents significantly decreased after the reopening of schools, whereas that to others, such as peers, increased. Such effects were not observed in infants and preschoolers. The follow-up survey 9-month after the reopening of schools (T3; n = 130) did not detect significant differences in both children’s socio-emotional behavior and perceived proximity from that after the intense quarantine. These findings suggest that school closure and home confinement may have influenced children’s social development differently across their age, and its effects were larger in perceived closeness rather than social behavior. | Please summerize the given abstract to a title |
Ultrasound wave exchange between COVID-19 virus and host cells | BACKGROUND: A way to control or cure viral diseases like the Coronavirus is the use of exchanged waves between viral RNAs and cellular DNAs In this research, we propose a model to compare the structure of cells and Corona viruses with the structure of speakers/microphones and obtain the frequency and the shape of exchanged waves This is a theoretical and a mathematical model Real material of this model are both Coronaviruses and host cells METHODS: In this model, the cellular DNA and viral RNA are formed from charged particles and by their motions, some electromagnetic waves are emerged In fact, they act like the inductors within speakers/microphones and produce some magnetic fields These fields interact with charges around nuclear and viral membranes and produce some currents along them In these conditions, membranes act like the magnet within speakers/microphones and emit some new magnetic fields These fields interact with DNA and viral inductors, move them and produce some extra magnetic waves, These waves move charges along viral and nuclear membranes, vibrate them and produce some sound waves RESULTS: Shape of DNA ultrasound waves depend on their RNA/DNA sources A cellular DNA coils several times around the histone and supercoiled axes and produce linear, toroid and round inductors A viral RNA coils and creates round viral inductor These inductors are formed from hexagonal and pentagonal bases and emit hexagonal/pentagound linear/curved sound waves CONCLUSIONS: Frequency of DNA sound waves could be between 107 -1020 (Hz) Also, frequency of viral sound waves could be between 107 -1011 [KVirus/KCell] where KVirus, KCell are some constants depending on the genus of liquids within viral and cell membranes In some conditions, KVirus/KCell=1 and virus could be absorbed by cells | Please summerize the given abstract to a title |
Bacillus Calmette-Guérin-induced trained immunity protects against SARS-CoV-2 challenge in K18-hACE2 mice | SARS-CoV-2 has resulted in over 450 million confirmed cases since 2019. Although several vaccines have been certified by World Health Organization and are being vaccinated on a global scale, it has been reported that multiple SARS-CoV-2 variants can escape neutralisation by antibodies, resulting in vaccine breakthrough infections. Bacillus Calmette-Guérin (BCG) is known to induce heterologous protection based on trained immune responses. Here, we investigated whether BCG-induced trained immunity protected against SARS-CoV-2 challenge in the K18-hACE2 mouse model. Our data demonstrates that intravenous BCG vaccination induces robust trained innate immune responses and provides protection against wild-type SARS-CoV-2 as well as the B.1.617.1 and B.1.617.2 variants. Further studies suggest that myeloid cell differentiation and activation of the glycolysis pathway are associated with BCG-induced training immunity in the K18-hACE2 mice. Overall, our study provides the experimental evidence that establishes a causal relationship between intravenous BCG vaccination and protection against SARS-CoV-2 challenge. | Please summerize the given abstract to a title |
Relation of corona-specific health literacy to use of and trust in information sources during the COVID-19 pandemic | BACKGROUND: COVID-19 has developed into a worldwide pandemic which was accompanied by an «infodemic» consisting of much false and misleading information. To cope with these new challenges, health literacy plays an essential role. The aim of this paper is to present the findings of a trend study in Switzerland on corona-specific health literacy, the use of and trust in information sources during the COVID-19 pandemic, and their relationships. METHODS: Three online surveys each with approximately 1′020 individuals living in the German-speaking part of Switzerland (age ≥ 18 years) were conducted at different timepoints during the COVID-19 pandemic, namely spring, fall and winter 2020. For the assessment of corona-specific health literacy, a specifically developed instrument (HLS-COVID-Q22) was used. Descriptive, bivariate, and multivariate data analyses have been conducted. RESULTS: In general, a majority of the Swiss-German population reported sufficient corona-specific health literacy levels which increased during the pandemic: 54.6% participants in spring, 62.4% in fall and 63.3% in winter 2020 had sufficient corona-specific health literacy. Greatest difficulties concerned the appraisal of health information on the coronavirus. The most used information sources were television (used by 73.3% in spring, 70% in fall and 72.3% in winter) and the internet (used by 64.1, 64.8 and 66.5%). Although health professionals, health authorities and the info-hotline were rarely mentioned as sources for information on the coronavirus, respondents had greatest trust in them. On the other hand, social media were considered as the least trustworthy information sources. Respondents generally reporting more trust in the various information sources, tended to have higher corona-specific health literacy levels. CONCLUSIONS: Sufficient health literacy is an essential prerequisite for finding, understanding, appraising, and applying health recommendations, particularly in a situation where there is a rapid spread of a huge amount of information. The population should be supported in their capability in appraising the received information and in assessing the trustworthiness of different information sources. | Please summerize the given abstract to a title |
Nurse Leaders' Experiences and Learnings Navigating Through the Chaos of a Pandemic | This article explores the experiences and learnings of 2 ambulatory care nurse leaders on the front lines of the Covid-19 pandemic using the theory "navigating through chaos" as a framework. | Please summerize the given abstract to a title |
Human mobility and poverty as key drivers of COVID-19 transmission and control | BACKGROUND: Applying heavy nationwide restrictions is a powerful method to curtail COVID-19 transmission but poses a significant humanitarian and economic crisis. Thus, it is essential to improve our understanding of COVID-19 transmission, and develop more focused and effective strategies. As human mobility drives transmission, data from cellphone devices can be utilized to achieve these goals. METHODS: We analyzed aggregated and anonymized mobility data from the cell phone devices of> 3 million users between February 1, 2020, to May 16, 2020 - in which several movement restrictions were applied and lifted in Israel. We integrated these mobility patterns into age-, risk- and region-structured transmission model. Calibrated to coronavirus incidence in 250 regions covering Israel, we evaluated the efficacy and effectiveness in decreasing morbidity and mortality of applying localized and temporal lockdowns (stay-at-home order). RESULTS: Poorer regions exhibited lower and slower compliance with the restrictions. Our transmission model further indicated that individuals from impoverished areas were associated with high transmission rates. Considering a horizon of 1-3 years, we found that to reduce COVID-19 mortality, school closure has an adverse effect, while interventions focusing on the elderly are the most efficient. We also found that applying localized and temporal lockdowns during regional outbreaks reduces the overall mortality and morbidity compared to nationwide lockdowns. These trends were consistent across vast ranges of epidemiological parameters, and potential seasonal forcing. CONCLUSIONS: More resources should be devoted to helping impoverished regions. Utilizing cellphone data despite being anonymized and aggregated can help policymakers worldwide identify hotspots and apply designated strategies against future COVID-19 outbreaks. | Please summerize the given abstract to a title |
Diagnostic testing holds the key to NTD elimination | “Fit-for-purpose” diagnostic tests have emerged as a prerequisite to achieving global targets for the prevention, control, elimination, and eradication of neglected tropical diseases (NTDs), as highlighted by the World Health Organization’s (WHO) new roadmap. There is an urgent need for the development of new tools for those diseases for which no diagnostics currently exist and for improvement of existing diagnostics for the remaining diseases. Yet, efforts to achieve this, and other crosscutting ambitions, are fragmented, and the burden of these 20 debilitating diseases immense. Compounded by the Coronavirus Disease 2019 (COVID-19) pandemic, programmatic interruptions, systemic weaknesses, limited investment, and poor commercial viability undermine global efforts—with a lack of coordination between partners, leading to the duplication and potential waste of scant resources. Recognizing the pivotal role of diagnostic testing and the ambition of WHO, to move forward, we must create an ecosystem that prioritizes country-level action, collaboration, creativity, and commitment to new levels of visibility. Only then can we start to accelerate progress and make new gains that move the world closer to the end of NTDs. | Please summerize the given abstract to a title |
Oxidation of phthalate acid esters using hydrogen peroxide and polyoxometalate/graphene hybrids | Phthalate acid esters (PAEs) have been adsorbed and oxidatively degraded into small molecules including lactic acid (LA), formic acid (FA), H2O and CO2 using polyoxometalates (POMs)/graphene hybrids. We demonstrated that super-lower concentrations of PAEs could be oxidized, which was due to their unique structure. POM molecules have been embedded onto graphene to form H5PMo10V2O40@surfactant(n)/Graphene(L wt%) (abbreviated as HPMoV@Surf(n)/GO(L wt%)) using surfactants with the carbon chain length n = 2, 4, 6 and 8 for the loading of HPMoV. The coexistence of the graphene and surfactant layer (on HPMoV@Surf(n)/GO(20 wt%)) adsorbed PAE molecules and transported them rapidly to HPMoV active sites. And n values determined the electron transfer ability between graphene and POMs that promoted PAEs oxidation. The loading of POMs on the surface of graphene permitted HPMoV@Surf(n)/GO(L wt%) act as interfacial catalyst which degraded various PAEs (i.e., diethyl phthalate (DEP), diallyl phthalate (DAP) and di (2-ethylhexyl) phthalate (DEHP)) while removed more than 70% of TOC and COD. The degradation of DEP achieved 93.0% with HPMoV@Surf(n)/GO(20 wt%) and H2O2, which followed ï¬rst-order kinetics and the reaction activation energy (Ea) of 23.1 kJ/mol. Further, HPMoV@Surf(n)/GO(20 wt%) showed potential for the removal of PAEs in Wastewater Treatment Plant (WWTP), and the degradation efficiency for PAE (DEP) in secondary effluent achieved 55.0%. In addition, the loading method for POMs on graphene eliminated the leaching of POMs from graphene, and the degradation efficiency could still reach 88.1% after ten recycles. | Please summerize the given abstract to a title |
Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors | The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) is a global health emergency. An attractive drug target among coronaviruses is the main protease (Mpro, also called 3CLpro) because of its essential role in processing the polyproteins that are translated from the viral RNA. We report the x-ray structures of the unliganded SARS-CoV-2 Mpro and its complex with an α-ketoamide inhibitor. This was derived from a previously designed inhibitor but with the P3-P2 amide bond incorporated into a pyridone ring to enhance the half-life of the compound in plasma. On the basis of the unliganded structure, we developed the lead compound into a potent inhibitor of the SARS-CoV-2 Mpro The pharmacokinetic characterization of the optimized inhibitor reveals a pronounced lung tropism and suitability for administration by the inhalative route. | Please summerize the given abstract to a title |
Post-traumatic stress symptoms in hemodialysis patients with MERS-CoV exposure | BACKGROUND: Post-traumatic stress symptoms can occur in patients with medical illness. During the Middle East Respiratory Syndrome (MERS) outbreak in South Korea in 2015, some dialysis patients in three centers who were incidentally exposed to patients or medical staff with confirmed MERS-CoV infection were isolated to interrupt the spread of the infection. We aimed to investigate post-traumatic stress symptoms and risk factors among these patients. MATERIALS AND METHODS: In total, 116 hemodialysis (HD) patients in contact with MERS-CoV-confirmed subjects were isolated using three strategies, namely, single room isolation, cohort isolation, and self-quarantine. We used the Impact of Event Scale-Revised-Korean (IES-R-K) to examine post-traumatic stress symptoms at 12 months after the isolation period. RESULTS: Of the 116 HD patients, 27 were lost to follow-up. Of the 89 patients, 67 (75.3%) completed the questionnaires. Single room isolation was used on 40 (58.8%) of the patients, cohort isolation on 20 (29.4%), and self-imposed quarantine on 8 (11.8%). In total, 17.9% of participants (n = 12) reported post-traumatic stress symptoms exceeding the IES-R-K’s cutoff point (≧18). Prevalence rates of IES-R-K ≧18 did not differ significantly according to isolation method. However, isolation duration was linearly associated with the IES-R-K score (standardized β coefficient − 0.272, P = 0.026). Scores in Avoidance, Emotional numbing and Dissociation subscale were higher in patients with longer isolation period. CONCLUSION: MERS was a traumatic experience for quarantined HD patients. IES-R-K scores were not significantly different by isolation methods. However, short isolation was associated with post-traumatic stress symptoms. | Please summerize the given abstract to a title |
CT lung lesions as predictors of early death or ICU admission in COVID-19 patients | OBJECTIVE: The main objective of this study was to investigate the prognostic value of early systematic chest computed tomography (CT) with quantification of lung lesions in coronavirus disease 2019 (COVID-19) patients. METHODS: We studied 572 patients diagnosed with COVID-19 (confirmed using polymerase chain reaction) for whom a chest CT was performed at hospital admission. Visual quantification was used to classify patients as per the percentage of lung parenchyma affected by COVID-19 lesions: normal CT, 0-10%, 11-25%, 26-50%, 51-75% and >75%. The primary endpoint was severe disease, defined by death or admission to the intensive care unit in the 7 days following first admission. RESULTS: The mean patient age was 66.0 ± 16.0 years, and 343/572 (60.0%) were men. The primary endpoint occurred in 206/572 patients (36.0%). The extent of lesions on initial CT was independently associated with prognosis (odds ratio = 2.35, 95% confidence interval 1.24-4.46; p < 0.01). Most patients with lung involvement >50% (66/95, 69.5%) developed severe disease compared to patients with lung involvement of 26-50% (70/171, 40.9%) and ≤25% (70/306, 22.9%) (p < 0.01 and p < 0.01, respectively). None of the patients with normal CT (0/14) had severe disease. CONCLUSION: Chest CT findings at admission are associated with outcome in COVID-19 patients. | Please summerize the given abstract to a title |
Claimed medical malpractice in fatal SARS-CoV-2 infections: the importance of combining ante- and post-mortem radiological data and autopsy findings for correct forensic analysis | We present the case of an elderly woman who died from COVID-19 during the first wave of the pandemic. The physicians in charge of the patient were later accused of medical malpractice resulting in the death of the patient. The article reviews the comprehensive medico-legal investigations into this case that included an analysis of the medical history, clinical imaging, post-mortem imaging, autopsy, histopathology, and microbiology as well as an assessment of the medical knowledge regarding transmission of the SARS-CoV-2 virus and the management of COVID-19 at the time of the patient's death. The investigation resulted in a verdict of not guilty. This case highlights the value of clinical and post-mortem imaging as well as various challenges of medico-legal investigations of COVID-19 related deaths. | Please summerize the given abstract to a title |
Risk conditions in healthcare workers of a pediatric coronavirus disease center in Mexico City | BACKGROUND: The new evere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is characterized by its high capacity to transmit. Health-care personnel is highly susceptible to becoming infected. This study aimed to determine the characteristics and known risk factors for contagion and severe outcomes of SARS-CoV-2 disease in health-care personnel of a pediatric coronavirus disease (COVID) center in Mexico City. METHODS: In the last week of March 2020 (at the beginning of phase 2 of the Ministry of Health's national campaign in Mexico), a study was conducted on healthcare workers of a pediatric COVID hospital in Mexico City. Using a virtual interview, we evaluated comorbidities, mobility, areas and functions where they carry out the activities, protection measures, contact history, and vaccination. According to their activities, healthcare workers were classified into the following areas: medical, nursing, other health-care personnel (researchers, nutritionists, rehabilitation, imaging, and laboratory), administrative, and other services. We compared the variables between the groups of healthcare workers with the X2 test. RESULTS: We included 812 participants. The mean age was 41 ± 11 years, and 33% were overweight or obese, 18% were over 60 years old, and 19% had high blood pressure. Medical and nursing personnel presented a higher proportion in the use of standard protection measures. CONCLUSIONS: Among healthcare workers, there are risk conditions for the development of complications in case of SARS-CoV-2 infection. Most medical and nursing personnel use standard protective measures. | Please summerize the given abstract to a title |
Prise en charge des infections des voies respiratoires basses de l'immunocompétent. Partie concernant les définitions, l'épidémiologie et les éléments du diagnostic | Particular attention is given to lower respiratory tract infections because of their frequency and potential severity. These infections represent a major cause of death worldwide and pneumonia remains the first cause of death from infectious origin in France. Three nosological entities are usually described according to the anatomic localization of the infectious process: acute bronchitis, pneumonia, and bronchopneumonia (if the infection involves the bronchial tree and the lung parenchyma). If bronchial infection occurs within the context of a chronic respiratory tract disease, it is called acute decompensation of chronic lung disease (usually chronic obstructive pulmonary disease). The major diagnostic difficulties are to be able to confirm alveolar implication in the infectious process and to determine the pathogenic agent(s) responsible for the clinical pattern. This information is essential for subsequent care depends. Apart from clinical examination, essential in this context, only chest-X-rays can be of any help to confirm alveolar involvement in the disease process. On the contrary, the interest of systematic microbiological confirmation and its value according to various techniques and swab conditions may be questioned for the clinical diagnosis. Microbiological confirmation does not seem essential in every case. The feasibility and relevance of microbiological techniques must be determined before any decision is taken on documentation. The microbiological documentation value depends on its yield and sensitivity profile in identifying the pathogen. | Please summerize the given abstract to a title |
Pituitary apoplexy: An emergent and potential life-threatening complication of pituitary adenomas | BACKGROUND: Pituitary apoplexy is an emergent and potential life-threatening complication of pituitary adenomas if not managed properly. The aim of our study is to present our series of pituitary adenomas and to focus on the clinical, radiological, and surgical characteristics of this rare complication. METHODS: In this study, a total of 143 patients with pituitary adenoma underwent surgical treatment between 2016 and 2018. All patients were operated using endoscopic endonasal transsphenoidal (EET) technique. The data of pituitary apoplexy cases were recorded. Resection rates, hormonal results, and visual outcomes of patients with pituitary apoplexy were evaluated. RESULTS: Of the 143 patients, 8 (5.59%) were presented with the symptoms and radiological findings of pituitary apoplexy. The mean age was 26.75 years, and 4 (50%) of them were male and 4 were female. Pre-operative mean Knosp grading score was 2.1 All of eight patients underwent emergent surgical intervention and total resection was achieved in 75% of patients with apoplexy. Hormone levels were significantly decreased after surgery (p<0.05), except prolactin (p>0.05). Cerebrospinal fluid leakage occurred in one pa-tient. None of the patient with pituitary apoplexy died in our series. CONCLUSION: Pituitary apoplexy is an important complication of pituitary adenomas. Early diagnosis and surgical intervention provide excellent ophthalmological and hormonal outcomes. Emergent EET approach is crucial for patients with ophthalmological findings and macroadenomas. | Please summerize the given abstract to a title |
Safeguarding children under Covid-19: What are we learning? | Purpose: The purpose of this paper is to identify and share learning about safeguarding children under Covid-19 drawn from a series of webinars held by the Association of Safeguarding Partners (www theASP org uk) The learning is relevant for health, police, local authority and other relevant safeguarding agencies and includes sharing information about both the challenges and opportunities presented during the Covid-19 pandemic By creating a webinar lead community of learning, lessons can be drawn that will help safeguard children during the remaining of the pandemic and during the release of lockdown as it emerges Design/methodology/approach: This paper summarises themes from discussions within three webinars run by The Association of Safeguarding Partners (TASP) (www theASP org uk) Each webinar was attended by between 60 and 80 participants, sessions involving presentations and discussions on topics such as “managing safeguarding reviews at a distance”, “the impact on early years’ provision” and “how work with families and children has changed with remote working methods” With the participants’ consent, webinars were recorded, and these can be viewed on www theasp co uk Webinars were supported by an on-line programme: “meeting sphere” capturing comments in a “chat” facility and providing capacity for participants to collectively code comments into themes Findings: Findings from the webinars note concerns about continuing and undetected abuse of children within and outside of the home;about the changing nature of criminal exploitation;and about the strains created by social distancing on children in families experiencing problems with poor mental health, drug and alcohol misuse and domestic abuse Findings include some important lessons, including the discovery of innovative ways of working, the rapid collation of data across partnerships and about different methods of engaging with children, young people and families Findings include suggestions about the impact of changes on the future safeguarding of children Originality/value: There is little published discussion of the implications of Covid-19 on practitioners working on safeguarding children While some research is emerging, there have been few opportunities for practitioners to listen to emerging practice ideas under Covid-19 or to discuss in an informal context how to address the new and emerging problems in safeguarding children This think piece contains original material from webinars held with safeguarding children practitioners and is valuable for those working to safeguard children during and post Covid-19 © 2020, Emerald Publishing Limited | Please summerize the given abstract to a title |
Illuminating the Gateway of Gene Silencing: Perspective of RNA Interference Technology in Clinical Therapeutics | A novel laboratory revolution for disease therapy, the RNA interference (RNAi) technology, has adopted a new era of molecular research as the next generation “Gene-targeted prophylaxis.” In this review, we have focused on the chief technological challenges associated with the efforts to develop RNAi-based therapeutics that may guide the biomedical researchers. Many non-curable maladies, like neurodegenerative diseases and cancers have effectively been cured using this technology. Rapid advances are still in progress for the development of RNAi-based technologies that will be having a major impact on medical research. We have highlighted the recent discoveries associated with the phenomenon of RNAi, expression of silencing molecules in mammals along with the vector systems used for disease therapeutics. | Please summerize the given abstract to a title |
An Analysis of the Intention of Students Studying at Physical Education and Sports School to Use Synchronous Virtual Classroom Environments during the COVID-19 Pandemic Period | This study aims to analyze the intention of students studying at physical education and sports school to use synchronous virtual classroom environments during the Covid-19 pandemic period. The research was designed in a descriptive survey model with a quantitative approach. The study group of the research consists of 193 voluntary students studying at School of Physical Education and Sports in a State University in the spring semester of the 2020-2021 academic year. The data of the research were collected with the "Personal Information Form" and the "Synchronous Virtual Classroom Acceptance Scale" in order to determine the students' intention to use synchronous virtual classroom environments. It has been determined following the study that the intention of students to use synchronous virtual classroom environments is generally positive and these intentions are at higher level in the "Subjective Norm" and "Self-efficacy" sub-dimensions, and lower in the "Perceived Ease of Use" subdimension. We have found that the students' intention to use synchronous virtual classroom environments does not change significantly according to the variables of gender and the department they study, but changed significantly according to the variable of the class they studied while the students studying in the first year have more positive intentions to use the synchronous virtual classroom environments than the students studying in other classes. In addition, it has been concluded that the intention of using the synchronous virtual classroom environments of the students who have a personal computer and an internet-connected smart phone and the students who access the lessons from their home with a laptop computer is more positive than the other groups. | Please summerize the given abstract to a title |
The role of DBP gene polymorphisms in the prevalence of new coronavirus disease 2019 infection and mortality rate | Since December 2019, coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome coronavirus 2, has given rise to emerging respiratory infections with pandemic diffusion. The vitamin D binding protein (DBP) with emphasis on its regulation of total and free vitamin D metabolite levels participate in various clinical conditions. The main goal of this study was to evaluate if there was any association between the DBP gene polymorphism at rs7041 and rs4588 loci and the prevalence of COVID‐19 and its mortality rates caused among populations of 10 countries including Turkey. Positive significant correlations were found between the prevalence (per million) and mortality rates (per million), and GT genotype (P < .05) while there was a negative significant correlation between prevalence (per million) and mortality rates (per million), and TT genotype at rs7041 locus among all populations (P < .05). However, no significant correlation was found at rs4588 locus. GT genotype was found to confer this susceptibility to the populations of Germany, Mexico, Italy, Czech, and Turkey. The variations in the prevalence of COVID‐19 and its mortality rates among countries may be explained by Vitamin D metabolism differed by the DBP polymorphisms of rs7041 and rs4588. | Please summerize the given abstract to a title |
Limited impact of Delta variants mutations in the effectiveness of neutralization conferred by natural infection or COVID-19 vaccines in a Latino population | The SARS-CoV-2 pandemic has impacted public health systems all over the world. The Delta variant seems to possess enhanced transmissibility, but no clear evidence suggests it has increased virulence. Our data shows that pre-exposed individuals had similar neutralizing activity against the authentic COVID-19 strain and the Delta and Epsilon variants. After one vaccine dose, the neutralization capacity expands to all tested variants. Healthy vaccinated individuals showed a limited breadth of neutralization. One vaccine dose induced similar neutralizing antibodies against the Delta compared to the authentic strain. However, even after two doses, this capacity only expanded to the Epsilon variant. | Please summerize the given abstract to a title |
Application of an Artificial Intelligence Trilogy to Accelerate Processing of Suspected Patients With SARS-CoV-2 at a Smart Quarantine Station: Observational Study | BACKGROUND: As the COVID-19 epidemic increases in severity, the burden of quarantine stations outside emergency departments (EDs) at hospitals is increasing daily. To address the high screening workload at quarantine stations, all staff members with medical licenses are required to work shifts in these stations. Therefore, it is necessary to simplify the workflow and decision-making process for physicians and surgeons from all subspecialties. OBJECTIVE: The aim of this paper is to demonstrate how the National Cheng Kung University Hospital artificial intelligence (AI) trilogy of diversion to a smart quarantine station, AI-assisted image interpretation, and a built-in clinical decision-making algorithm improves medical care and reduces quarantine processing times. METHODS: This observational study on the emerging COVID-19 pandemic included 643 patients. An “AI trilogy” of diversion to a smart quarantine station, AI-assisted image interpretation, and a built-in clinical decision-making algorithm on a tablet computer was applied to shorten the quarantine survey process and reduce processing time during the COVID-19 pandemic. RESULTS: The use of the AI trilogy facilitated the processing of suspected cases of COVID-19 with or without symptoms; also, travel, occupation, contact, and clustering histories were obtained with the tablet computer device. A separate AI-mode function that could quickly recognize pulmonary infiltrates on chest x-rays was merged into the smart clinical assisting system (SCAS), and this model was subsequently trained with COVID-19 pneumonia cases from the GitHub open source data set. The detection rates for posteroanterior and anteroposterior chest x-rays were 55/59 (93%) and 5/11 (45%), respectively. The SCAS algorithm was continuously adjusted based on updates to the Taiwan Centers for Disease Control public safety guidelines for faster clinical decision making. Our ex vivo study demonstrated the efficiency of disinfecting the tablet computer surface by wiping it twice with 75% alcohol sanitizer. To further analyze the impact of the AI application in the quarantine station, we subdivided the station group into groups with or without AI. Compared with the conventional ED (n=281), the survey time at the quarantine station (n=1520) was significantly shortened; the median survey time at the ED was 153 minutes (95% CI 108.5-205.0), vs 35 minutes at the quarantine station (95% CI 24-56; P<.001). Furthermore, the use of the AI application in the quarantine station reduced the survey time in the quarantine station; the median survey time without AI was 101 minutes (95% CI 40-153), vs 34 minutes (95% CI 24-53) with AI in the quarantine station (P<.001). CONCLUSIONS: The AI trilogy improved our medical care workflow by shortening the quarantine survey process and reducing the processing time, which is especially important during an emerging infectious disease epidemic. | Please summerize the given abstract to a title |
Lateral interbody fusion at L4/5: management of the transitional psoas. | OBJECTIVE Managing retraction of the lumbar plexus is critical to safely performing lateral lumbar interbody fusion (LLIF) via the transpsoas approach. Occasionally, a transitional psoas is encountered at L4/5 and has been postulated to be a contraindication to transpsoas LLIF. A case series of patients with transitional psoas who underwent L4/5 LLIFs is presented. METHODS This retrospective review assessed 79 consecutive patients who underwent L4/5 LLIF during a 24-month period. Preoperative imaging was reviewed, and patients were classified into 2 groups: normal psoas or transitional psoas. Intraoperative features and outcomes were compared between groups. RESULTS Seventy-nine patients underwent L4/5 LLIFs, of whom 23 had transitional psoas anatomy and 56 had normal psoas anatomy. Among patients with transitional psoas, the center of the psoas was a mean (range) of 11.2 (5.2-26.6) mm in front of the center of the vertebral body compared with 2.0 (0-4) mm in the normal psoas group. The mean (range) retraction time was similar between groups (10.8 [6.7-14.9] minutes in the TP group versus 11.0 [7.8-15.0] minutes in the NP group). No permanent motor injuries occurred in either group, and no differences in length of stay or preoperative or postoperative Oswestry Disability Index scores were found between the groups. The protocol for L4/5 LLIF in patients with transitional psoas anatomy is described. CONCLUSIONS Transitional psoas anatomy is frequently encountered in surgical candidates for L4/5 LLIF. Through careful identification of the lumbar plexus and judicious retraction, the transpsoas LLIF can safely be performed in these patients. | Please summerize the given abstract to a title |
Dose-response relationship between cooking fumes exposures and lung cancer among Chinese nonsmoking women. | The high incidence of lung cancer among Chinese females, despite a low smoking prevalence, remains poorly explained. Cooking fume exposure during frying could be an important risk factor. We carried out a population-based case-control study in Hong Kong. Cases were Chinese female nonsmokers with newly diagnosed primary lung cancer. Controls were female nonsmokers randomly sampled from the community, frequency matched by age groups. Face-to-face interviews were conducted using a standardized questionnaire. The "total cooking dish-years," categorized by increments of 50, was used as a surrogate of cooking fumes exposure. Multiple unconditional logistic regression was used to estimate the odds ratios (OR) for different levels of exposure after adjusting for various potential confounding factors. We interviewed 200 cases and 285 controls. The ORs of lung cancer across increasing levels of cooking dish-years were 1, 1.17, 1.92, 2.26, and 6.15. After adjusting for age and other potential confounding factors, the increasing trend of ORs with increasing exposure categories became clearer, being 1, 1.31, 4.12, 4.68, and 34. The OR of lung cancer was highest for deep-frying (2.56 per 10 dish-years) followed by that of frying (1.47), and stir-frying had the lowest OR (1.12) among the three methods. Cumulative exposure to cooking by means of any form of frying could increase the risk of lung cancer in Hong Kong nonsmoking women. Practical means to reduce exposures to cooking fumes should be given top priority in future research. | Please summerize the given abstract to a title |
Serum biomarkers of oxidative stress in cats with feline infectious peritonitis | The purpose of this study was to elucidate the possible presence of oxidative stress in cats naturally affected by feline infectious peritonitis (FIP) by investigating two antioxidant biomarkers in serum: paraoxonase-1 (PON1) and total antioxidant capacity (TAC). PON1 was measured by spectrophotometric assays using three different substrates: p-nitrophenyl acetate (pNA), phenyl acetate (PA) and 5-thiobutil butyrolactone (TBBL), in order to evaluate possible differences between them. The PA and TBBL assays for PON1 and the assay for TAC were validated, providing acceptable precision and linearity although PA and TAC assays showed limit of detection higher than the values found in some cats with FIP. Cats with FIP and other inflammatory conditions showed lower PON1 values compared with a group of healthy cats with the three assays used, and cats with FIP showed significant decreased TAC concentrations. This study demonstrated the existence of oxidative stress in cats with FIP. | Please summerize the given abstract to a title |
Clinical characteristics of 4499 COVID-19 patients in Africa: A meta-analysis | The novel coronavirus disease-2019 (COVID-19) pandemic that started in December 2019 has affected over 95 million people and killed over 2 million people as of January 19, 2021. While more studies are published to help us understand the virus, there is a dearth of studies on the clinical characteristics and associated outcomes of the severe acute respiratory syndrome coronavirus 2 on the African continent. We evaluated evidence from previous studies in Africa available in six databases between January 1 and October 6, 2020. Meta-analysis was then performed using Open-Meta Analyst and Jamovi software. A total of seven studies, including 4499 COVID-19 patients, were included. The result of the meta-analysis showed that 68.8% of infected patients were male. Common symptoms presented (with their incidences) were fever (42.8%), cough (33.3%), headache (11.3%), and breathing problems (16.8%). Other minor occurring symptoms included diarrhea (7.5%) and rhinorrhea (9.4%). Fatality rate was 5.6%. There was no publication bias in the study. This study presents the first description and analysis of the clinical characteristics of COVID-19 patients in Africa. The most common symptoms are fever, cough, and breathing problems. | Please summerize the given abstract to a title |
Learn as you go. University Teaching Practices in Public Health and the Coronavirus Pandemic | This article reflects on the teachers' job in a context influenced by both the pandemic and the preventive social isolation measures applied by the Argentinian National Government from the end of March 2020. Through the strategy of systematization, experiences, tensions, and challenges of virtual classes in the subject Problematica de la Salud (Public Health Problems) in the social work degree at Universidad Nacional de Cuyo (Uncuyo or Cuyo's National University in English) located in the Mendoza province are analyzed. Some recent debates related to virtual education in university contexts are reconsidered and it is from them that we analyze in which way were the contents, the practical activities plan, the learning objectives, the teacher's role, and the experiences of the alumni, affected or influenced by a pandemic context and the type of virtual education that this imposed. In the end, we cover to what extent we were able to take advantage of the potentialities that the virtual learning provides, as well as how its limitations had an impact | Please summerize the given abstract to a title |
Latin American databases of natural products: biodiversity and drug discovery against SARS-CoV-2† † Electronic supplementary information (ESI) available. See DOI: 10.1039/d1ra01507a | In this study, we evaluated 3444 Latin American natural products using cheminformatic tools. We also characterized 196 compounds for the first time from the flora of El Salvador that were compared with the databases of secondary metabolites from Brazil, Mexico, and Panama, and 42 969 compounds (natural, semi-synthetic, synthetic) from different regions of the world. The overall analysis was performed using drug-likeness properties, molecular fingerprints of different designs, two parameters similarity, molecular scaffolds, and molecular complexity metrics. It was found that, in general, Salvadoran natural products have a large diversity based on fingerprints. Simultaneously, those belonging to Mexico and Panama present the greatest diversity of scaffolds compared to the other databases. This study provided evidence of the high structural complexity that Latin America's natural products have as a benchmark. The COVID-19 pandemic has had a negative effect on a global level. Thus, in the search for substances that may influence the coronavirus life cycle, the secondary metabolites from El Salvador and Panama were evaluated by docking against the endoribonuclease NSP-15, an enzyme involved in the SARS CoV-2 viral replication. We propose in this study three natural products as potential inhibitors of NSP-15. We performed a cheminfomatic analysis of four databases in Latin America and evaluated its potential in silico against SARS-CoV-2. | Please summerize the given abstract to a title |
COVID-19 and the ethics of quarantine: a lesson from the Eyam plague | The recent outbreak of the SARS-CoV-2 coronavirus is posing many different challenges to local communities, directly affected by the pandemic, and to the global community, trying to find how to respond to this threat in a larger scale. The history of the Eyam Plague, read in light of Ross Upshur’s Four Principles for the Justification of Public Health Intervention, and of the Siracusa Principles on the Limitation and Derogation Provisions in the International Covenant on Civil and Political Rights, could provide useful guidance in navigating the complex ethical issues that arise when quarantine measures need to be put in place. | Please summerize the given abstract to a title |
Coronavirus not a ‘mental health crisis,’ healthcare experts warn | A group of mental healthcare professionals has highlighted the dangers of labelling COVID-19 ‘a mental health crisis’ | Please summerize the given abstract to a title |
Investigating Adolescents’ Video Gaming and Gambling Activities, and Their Relationship With Behavioral, Emotional, and Social Difficulties: Protocol for a Multi-Informant Study | BACKGROUND: Growing empirical evidence suggests that adolescents have a relatively greater propensity to develop problematic video gaming or gambling habits. OBJECTIVE: The main objectives of this study are to estimate the prevalence of potential pathological gambling and video game use among adolescent students and to evaluate their risk factors. METHODS: This is a cross-sectional multi-informant study based on an online survey. It will include a sample of adolescents attending secondary schools located in Brescia, northern Italy, their schoolteachers, and parents. The survey includes extensive data on adolescents’ (1) demographic, social, economic, and environmental characteristics; (2) behavioral, emotional, and social problems and adaptive functioning; (3) emotional and social loneliness; (4) perception of the reasons to use social networks; (5) video game habits and pathological use of video gaming; and (6) gambling behaviors. RESULTS: This protocol was approved by the Institutional Ethics Board of the Spedali Civili of Brescia (Italy). We expect to collect data from 793 or more adolescent students, as determined by our sample size calculation. CONCLUSIONS: This multisite project will make a substantial contribution to (1) the implementation of a system for identifying pathological gambling and pathological video game use among adolescents, allowing for interventions aimed at improving adolescents’ financial, emotional, and social well-being; and (2) the identification of distinct profiles of gamblers and pathological video gamers that will contribute to setting up effective targeted prevention measures. Understanding the causes and impact of gambling and pathological video gaming on adolescents is a public health issue. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/33376 | Please summerize the given abstract to a title |
Knowledge on sudden unexplained infant death-related safe sleep practices and infant cardiopulmonary resuscitation in pediatric nurses | PURPOSE: Sudden unexplained infant death (SUID) is a major contributor to infant mortality, and pediatric nurses have the responsibility to educate parents on SUID-reducing strategies. This study was conducted to measure pediatric nurses’ knowledge of SUID-related safe sleep practices (K-SSSP) and infant cardiopulmonary resuscitation (K-ICPR). METHODS: In total, 136 pediatric nurses were administered a survey including K-SSSP (13 items), K-ICPR (5 items), confidence in K-SSSP education (1 item; 5 points), and other factors relating to SUID experiences or education. RESULTS: The correct answer rates of the K-SSSP and K-ICPR were 62.6% and 62.5%, retrospectively. The mean score for confidence in K-SSSP education was 2.6±0.9. Only 18 nurses (13.2%) responded that they educated parents on the content of the K-SSSP, while 76 nurses had received education on SUID. Positive relationships were observed between K-SSSP scores and higher education, between K-ICPR scores and having own child(ren) and clinical experience, and between confidence in K-SSSP education and higher education or having one’s own child(ren). Nurses caring for newborns performed more SUID education than nurses working in other units. CONCLUSION: There is a profound need to implement a systemic educational program on SUID and strategies to reduce SUID for pediatric nurses. | Please summerize the given abstract to a title |
Identification of estrogen receptor modulators as inhibitors of flavivirus infection. | Flaviviruses such as Zika virus (ZIKV), dengue virus (DENV) and West Nile virus (WNV) are major global pathogens for which safe and effective antiviral therapies are not currently available. To identify antiviral small molecules with well-characterized safety and bioavailability profiles we screened a library of 2,907 approved drugs and pharmacologically active compounds for inhibitors of ZIKV infection using a high-throughput cell-based immunofluorescence assay. Interestingly, estrogen receptor modulators raloxifene hydrochloride and quinestrol were amongst 15 compounds that significantly inhibited ZIKV infection in repeat screens. Subsequent validation studies revealed that these drugs effectively inhibit ZIKV, DENV and WNV (Kunjin strain) infection at low micromolar concentrations with minimal cytotoxicity in Huh-7.5 hepatoma cells and HTR-8 placental trophoblast cells. Since these cells lack detectable expression of estrogen receptors-α and -β (ER-α and ER-β) and similar antiviral effects were observed in the context of subgenomic DENV and ZIKV replicons, these compounds appear to inhibit viral RNA replication in a manner that is independent of their known effects on estrogen receptor signaling. Taken together, quinestrol, raloxifene hydrochloride and structurally related analogues warrant further investigation as potential therapeutics for treatment of flavivirus infections. | Please summerize the given abstract to a title |
Corticospinal-Evoked Responses from the Biceps Brachii during Arm Cycling across Multiple Power Outputs. | Background: We examined corticospinal and spinal excitability across multiple power outputs during arm cycling using a weak and strong stimulus intensity. Methods: We elicited motor evoked potentials (MEPs) and cervicomedullary motor evoked potentials (CMEPs) in the biceps brachii using magnetic stimulation over the motor cortex and electrical stimulation of corticospinal axons during arm cycling at six different power outputs (i.e., 25, 50, 100, 150, 200 and 250 W) and two stimulation intensities (i.e., weak vs. strong). Results: In general, biceps brachii MEP and CMEP amplitudes (normalized to maximal M-wave (Mmax)) followed a similar pattern of modulation with increases in cycling intensity at both stimulation strengths. Specifically, MEP and CMEP amplitudes increased up until ~150 W and ~100 W when the weak and strong stimulations were used, respectively. Further increases in cycling intensity revealed no changes on MEP or CMEP amplitudes for either stimulation strength. Conclusions: In general, MEPs and CMEPs changed in a similar manner, suggesting that increases and subsequent plateaus in overall excitability are likely mediated by spinal factors. Interestingly, however, MEP amplitudes were disproportionately larger than CMEP amplitudes as power output increased, despite being initially matched in amplitude, particularly with strong stimulation. This suggests that supraspinal excitability is enhanced to a larger degree than spinal excitability as the power output of arm cycling increases. | Please summerize the given abstract to a title |
Development of air and sea transport in the gcc in the context of the transition to sustainable development | This article is devoted to the transition of the Arab countries to the new concept of sustainable development (SD) in tourism, sea and air transport The challenges associated with the transition to sustainable development are implemented in state long-term strategies in the Arab countries The surge of interest to this concept of development was also due to the release of the 17 UN sustainable development goals (SDGs) in 2015, which replaced the Millennium development goals General questions of the development of the Gulf Cooperation Council countries at the beginning of the 21st century and the main prerequisites for creating large infrastructure facilities in the region owing to the increase of tourist inflow, especially the increasing number of Muslim pilgrims coming to Saudi Arabia, are considered at the beginning of the article There is a brief overview of the national air carriers and the system of large air hubs in the UAE and Qatar and data on SDG Index No 9 “Industry, Innovation and Infrastructure” in the Gulf Cooperation Council countries for 2017 and 2018 The article is concluded with the results of the investigation on the effect that the Persian Gulf monarchies have achieved in the field of passenger and cargo transportation as well as the problems of operating aviation infrastructure facilities in the context of the transition to sustainable development;it is also shown that the economic downturn and the COVID-19 pandemic, which caused the suspension of air travel in a number of countries in the spring of 2020, may have certain consequences © 2020 Russian Academy of Sciences All rights reserved | Please summerize the given abstract to a title |
A high-resolution typical pollution source emission inventory and pollution source changes during the COVID-19 lockdown in a megacity, China | To control the spread of COVID-19, China has imposed national lockdown policies to restrict the movement of its population since the Chinese New Year of January 2020. In this study, we quantitatively analyzed the changes of pollution sources in Shanghai during the COVID-19 lockdown; a high-resolution emission inventory of typical pollution sources including stationary source, mobile source, and oil and gas storage and transportation source was established based on pollution source data from January to February 2020. The results show that the total emissions of sulfur dioxide (SO2), nitrogen oxides (NOx), particulate matter (PM), and volatile organic compounds (VOCs) were 9520.2, 37,978.6, 2796.7, and 7236.9 tons, respectively, during the study period. Affected by the COVID-19 lockdown, the mobile source experienced the largest decline. The car mileage and oil sales decreased by about 80% during the COVID-19 lockdown (P3) when compared with those during the pre-Spring Festival (P1). The number of aircraft activity decreased by approximately 50%. The impact of the COVID-19 epidemic on industries such as iron and steel and petrochemicals was less significant, while the greater impact was on coatings, chemicals, rubber, and plastic. The emissions of SO2, NOx, PM2.5, and VOCs decreased by 11%, 39%, 37%, and 47%, respectively, during P3 when compared with those during P1. The results show that the measures to control the spread of the COVID-19 epidemic made a significant contribution to emission reductions. This study may provide a reference for other countries to assess the impact of the COVID-19 epidemic on emissions and help establish regulatory actions to improve air quality. | Please summerize the given abstract to a title |
Can Media Campaigns Empower Women Facing Gender-Based Violence amid COVID-19? | Women's exposure to gender-based and intimate partner violence (GBV and IPV) is particularly acute due to COVID-19, especially in the Global South. We test whether edutainment interventions that have been shown to successfully combat GBV and IPV when delivered in person can be effectively delivered using social (WhatsApp and Facebook) and traditional (TV) media. To do so, we randomized the mode of implementation of an intervention conducted by an Egyptian women’s rights non-governmental organization seeking to support women while accommodating social distancing amid COVID-19. We found WhatsApp to be a more effective way to deliver the intervention than Facebook, but no differences across outcomes between WhatsApp and TV dissemination. Our findings show that these media campaigns had no impact on women's attitudes toward gender or marital equality, or the justifiability of violence. However, the campaign did increase women's knowledge, hypothetical, and reported use of resources available to those exposed to GBV and IPV. | Please summerize the given abstract to a title |
Efficient and Effective Training of COVID-19 Classification Networks with Self-supervised Dual-track Learning to Rank. | Coronavirus Disease 2019 (COVID-19) has rapidly spread worldwide since first reported. Timely diagnosis of COVID-19 is crucial both for disease control and patient care. Non-contrast thoracic computed tomography (CT) has been identified as an effective tool for the diagnosis, yet the disease outbreak has placed tremendous pressure on radiologists for reading the exams and may potentially lead to fatigue-related mis-diagnosis. Reliable automatic classification algorithms can be really helpful; however, they usually require a considerable number of COVID-19 cases for training, which is difficult to acquire in a timely manner. Meanwhile, how to effectively utilize the existing archive of non-COVID-19 data (the negative samples) in the presence of severe class imbalance is another challenge. In addition, the sudden disease outbreak necessitates fast algorithm development. In this work, we propose a novel approach for effective and efficient training of COVID-19 classification networks using a small number of COVID-19 CT exams and an archive of negative samples. Concretely, a novel self-supervised learning method is proposed to extract features from the COVID-19 and negative samples. Then, two kinds of soft-labels ('difficulty' and 'diversity') are generated for the negative samples by computing the earth mover's distances between the features of the negative and COVID-19 samples, from which data 'values' of the negative samples can be assessed. A pre-set number of negative samples are selected accordingly and fed to the neural network for training. Experimental results show that our approach can achieve superior performance using about half of the negative samples, substantially reducing model training time. | Please summerize the given abstract to a title |
Introduction to the 2021 Progress Report | Welcome to the SMPTE 2021 Progress Report. What a year it has been. The emergence of vaccines against COVID-19 has highlighted the importance of documented, organized ways that large groups can work together toward a common goal. The vaccines gave hope that the world would go back to normal, but unfortunately, we are still a long way from globally returning to the prepandemic way of working. © 2002 Society of Motion Picture and Television Engineers, Inc. | Please summerize the given abstract to a title |
Mutagenic, Genotoxic and Immunomodulatory effects of Hydroxychloroquine and Chloroquine: a review to evaluate its potential to use as a prophylactic drug against COVID-19 | Hydroxychloroquine (HCQ) and Chloroquine (CQ) are two anti-malarial drugs that are now being extensively used by front-line healthcare workers and other common people as a prophylactic drug against the Corona Virus Disease − 19 (COVID-19) in India and as well as in many parts of the world. While only a few in vitro studies have pointed to some efficacy of these drugs as a prophylactic against COVID-19, to date, there are no clinical studies that have established any clinical efficacy of these drugs as a prophylactic. These drugs are commonly used for the treatment of Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE) because of its immunomodulatory effects. Previously, we have evaluated the genetic toxicology of different drugs and chemicals including antimalarial drug CQ both in vitro and in vivo. Thus, we recognize the need to critically review the mutagenic, genotoxic, and immunomodulatory effects of these drugs, to find out whether it is safe to use as a prophylactic drug against COVID-19. Existing literature suggests that CQ can induce mutagenic and genotoxic effects in multiple test systems and both the drugs have immunomodulatory effects. There was no data available to evaluate the mutagenicity and genotoxicity for HCQ. However, during metabolism about 60% of both the drugs remain unchanged and about 40% of the drugs are metabolized into two metabolites, desethylchloroquine and bisdesethylchloroquine by the action of the cytochrome P450 (CYP) enzymes in the liver. Both HCQ and CQ are immunomodulatory drugs and have the potential to suppress normal immune system activation. In this review, we have elucidated the mechanism of immunomodulation by both HCQ and CQ and highlighted the mutagenic and genotoxic effects from the available literature. This article is written with the sole objective that the reader will be able to recognize the adverse effects of these drugs when consumed by healthy individuals as a prophylactic. Current literature indicates that healthy individuals should refrain from the use of these drugs until further investigation. | Please summerize the given abstract to a title |
Overall reaction mechanism for a full atomic layer deposition cycle of W films on TiN surfaces: first-principles study | We investigated the overall ALD reaction mechanism for W deposition on TiN surfaces based on DFT calculation as well as the detailed dissociative reactions of WF6. Our calculated results suggest that the overall reactions of the WF6 on the B-covered TiN surfaces are energetically much more favorable than the one on the TiN surfaces, which means that the high reactivity of WF6 with the B-covered TiN surface is attributed to the presence of B-covered surface made by B2H6 molecules. As a result, an effect of the B2H6 flow serves as a catalyst to decompose WF6 molecules. Two additional reaction processes right after WF6 bond dissociation, such as W substitution and BF3 desorption, were also explored to clearly understand the detailed reactions that can occur by WF6 flow. At the first additional reaction process, W atoms can be substituted into B site and covered on the TiN surfaces due to the stronger bonding nature of W with the TiN surface than B atoms. At the second additional reaction process, remaining atoms, such as B and F, can be easily desorbed as by-product, that is, BF3 because BF3 desorption is an energetically favorable reaction with a low activation energy. Furthermore, we also investigated the effect of H2 post-treatment on W-covered TiN surface in order to remove residual F adatoms, which are known to cause severe problems that extremely degrade the characteristics of memory devices. It was found that both H2 dissociative reaction and HF desorption can occur sufficiently well under somewhat high temperature and H2 ambience, which is confirmed by our DFT results and previously reported experimental results. These results imply that the understanding of the role of gas molecules used for W deposition gives us insight into improving the W ALD process for future memory devices. | Please summerize the given abstract to a title |
Clinical Characteristics and Treatment Outcomes of Mild to Moderate Covid-19 Patients in Saudi Arabia: A Single Centre Study | OBJECTIVE: Since the severity of symptoms affects the treatment option for Coronavirus Disease 2019 (COVID-19) patients, the treatment pattern for mild to moderate non-ICU cases must be evaluated, particularly in the current scenario of mutation and variant strain for effective decision making. METHODS: The objective of retrospective analysis was to assess clinical and treatment outcomes in mild to moderate symptoms in non-ICU patients with COVID-19 who were admitted to major tertiary care hospitals in Al Baha, Saudi Arabia, between April and August 2020. RESULTS: A total of 811 people were admitted for COVID-19 treatment, age ranging from 14 to 66, diabetes mellitus (31%, n = 248) and hypertension (24%, n = 198) were the most common comorbid conditions. The hydroxychloroquine (HCQ) treated group (G1 n = 466) had an MD of 8 and an IQR of 5-13 for time in hospital with a 4.3% mortality rate, while the non-HCQ group (G2 n = 345) had an MD of 6 and an IQR of 3-11 for time in hospital with a 3.2% mortality rate. A combination of antiviral and antibiotic treatment was found to be effective, other most frequent intervention was analgesics 85.7%, anticoagulant 75%, minerals (Zinc 83% and Vit D3 82%). CONCLUSIONS: The therapy and clinical outcomes from the past will be the guiding factor to treat the mutant strain infection in the future. Patients treated with HCQ had a higher mortality rate, whereas those who were given a non-HCQ combination had a greater clinical outcome profile. DATA AVAILABILITY STATEMENT: Data available on request due to ethical restrictions. The anonymized data presented in this study are available on request from the corresponding author. The data are not publicly available to maintain privacy and adhere to guidelines of the ethics protocol. | Please summerize the given abstract to a title |
Breast Reconstruction in the Social Media Age | BACKGROUND: The internet and social media provide access to information regarding breast reconstruction, which can educate and influence patients. OBJECTIVES: This study aimed to evaluate current internet and social media usage for breast reconstruction patients and its impact on patients. METHODS: Eighty-six breast reconstruction patients over a 7-month period answered an anonymous survey, which queried demographics, reconstruction type, internet usage, social media usage, expectations, and impact on decisions. Fisher's exact test was performed to evaluate the use of social media. RESULTS: 95% of patients used the internet for breast reconstruction information. The information was easy to understand 70%, helpful 76%, and trustworthy 60%. The information influenced decisions regarding procedure 23%, surgeon 23%, and hospital 22%. Social media was used 71% of the time. 62% found it easy to understand, 57% helpful, and 48% trustworthy. The information influenced decisions regarding procedure 16%, surgeon 11%, and hospital 10%. 26% of women expected final breast reconstruction appearance to look better than their native pre-mastectomy breasts, 55% as good or similar, and 12% reported appearance as being unimportant. Women found social media information to be less helpful than internet information. There was no significant association between expectations and social media versus no social media usage. CONCLUSION: Patients who undergo breast reconstruction use the internet and social media for their information. Though the information is generally trusted, it does not seem to heavily influence patient decision making. Providers remain patient's main source of information, and need to direct patients to quality and accessible resources. | Please summerize the given abstract to a title |
A Patient with Eight Intracranial Aneurysms: Endovascular Treatment in Two Sessions. | The frequency of multiple intracranial aneurysms seen in patients with or without subarachnoid hemorrhage is high. The advancement of the endovascular technique and devices has ensured that endovascular treatment of intracranial aneurysms is the first choice in most cases, especially in unruptured ones. Different combinations of treatment modalities and techniques can be used in the management of multiple aneurysms. But in selected patients without subarachnoid hemorrhage, treatment of all aneurysms in one or more sessions with endovascular techniques is less traumatic than that with surgery. In the literature, the maximum number of aneurysms in one patient treated endovascularly and/or surgically is seven. In this case report, we present, with a review of the literature, a patient with eight intracranial aneurysms, all of which were treated in two sessions with various endovascular techniques. A 40-year-old female patient was admitted due to headache. Angiography showed eight aneurysms in the posterior circulation and, bilaterally, in the anterior circulation. All aneurysms were treated endovascularly in two sessions. In the treatment of the aneurysms, different endovascular techniques were used including flow diverters stents, stent-assisted coiling, Y-stent-assisted coiling, and coiling alone. | Please summerize the given abstract to a title |
Incarcerated individuals' experiences of COVID-19 in the United States | PURPOSE: This study aims to examine steps taken by correctional staff to prevent COVID-19 from spreading through correctional facilities and explores strategies used by incarcerated individuals to reduce their own risk of contracting COVID-19 during confinement. DESIGN/METHODOLOGY/APPROACH: Data were drawn from interviews with 327 individuals incarcerated after March 16, 2020, in Midwest1, Midwest2 and Southeast state using a questionnaire developed for this purpose. All study participants were actively involved in a randomized controlled trial of a behavioral health reentry intervention and the human subjects board approved the supplement of this study on COVID-19; interviews were conducted from April 15 to November 19, 2020. FINDINGS: Overall, 9.89% of participants contracted COVID-19. Most (68.50%) individuals learned about COVID-19 from television compared to official correctional facility announcements (32.42%). Participants wore face masks (85.02%), washed hands (84.40%) and practiced physical distancing when possible (66.36%). Participants reported that facilities suspended visitation (89.60%) and volunteers (82.57%), provided face masks (83.18%), sanitized (68.20%), conducted temperature checks (55.35%) and released individuals early (7.34%). SOCIAL IMPLICATIONS: Longitudinal observational study on the implementation and effectiveness of public health guidelines in prisons and jails may identify best practices for containing the infectious disease. Maximizing transparent communications, as well as COVID-19 prevention and mitigation efforts, are critical to achieving universal best practices for virus containment and amplifying public health. ORIGINALITY/VALUE: Data presented indicate the early adoption of many Centers for Disease Control guidelines by individuals and correctional facilities, although broad variation existed. Data support the identification of containment strategies for feasible implementation in a range of correctional spaces. | Please summerize the given abstract to a title |
Impact of rituximab on COVID-19 outcomes | Rituximab is associated with prolonged B-cell depletion and secondary hypogammaglobulinemia and is associated with a dampened humoral response and increased infectious complications. To describe the potential impact of prior rituximab therapy on clinical outcomes from SARS-CoV-2 infection and development of COVID-19 antibodies, we conducted a retrospective study of adults across the Mount Sinai Health System diagnosed with COVID-19 who received rituximab for any indication from February 2019 to October 2020. Patients’ baseline characteristics, markers of disease severity, clinical outcomes, and antibody development were examined. Of the 49 patients included in the analysis, 63.2% required hospitalization for COVID-19, 24.5% required an ICU admission, and 32.7% died. Proximity of last rituximab infusion and COVID-19 diagnosis did not affect rates of hospitalization, admission to intensive care units or death. Over half (51.7%) of those whose antibodies were checked developed neutralizing anti-spike protein antibodies. The median time between rituximab administration and COVID-19 diagnosis was not significantly different between those who developed antibodies and those who did not (p = .323). Of the 14 patients with documented negative COVID-19 antibody titers, 11 of them survived SARS-CoV-2 infection, indicating that development of neutralizing antibodies may not be necessary for recovery from COVID-19. | Please summerize the given abstract to a title |
Teatro de Reprise Telepresencial em tempos de COVID 19 (preprint)/ pt | Em tempos de quarentena da COVID 19 é essencial explorar ferramentas para enfrentar os desafios psicossociais provocados pelo isolamento e novas rotinas, além de buscar formas de satisfazer as necessidades de encontro, aproveitando recursos tecnológicos. O objetivo deste trabalho é apresentar e discutir uma adaptação do Teatro de Reprise com recursos de telepresença. O método do desenvolvimento foi o da pesquisa-ação. A intervenção específica foi iniciativa de um grupo de usuários de um centro cultural, em que se realizam Psicodramas Públicos presenciais regularmente. A partir do ponto de vista do psicodrama, esse trabalho discute as implicações e possibilidades do uso de uma plataforma tecnológica, os papéis das pessoas envolvidas e a possibilidade de novas sociometrias, em uma intervenção. | Please summerize the given abstract to a title |
Clinical Characteristics and Blood Test Results in COVID-19 Patients. | OBJECTIVE An outbreak of pneumonia named COVID-19 caused by a novel coronavirus in Wuhan is rapidly spreading worldwide. The objective of the present study was to clarify further the clinical characteristics and blood parameters in COVID-19 patients. MATERIALS AND METHODS Twenty-three suspected patients and 64 patients with laboratory-confirmed SARS-Cov-2 infection were admitted to a designated hospital. Epidemiological, clinical, laboratory, and treatment data were collected and analyzed. RESULTS Of the 64 patients studied, 47 (73.4%) had been exposed to a confirmed source of COVID-19 transmission. On admission, the most common symptoms were fever (75%) and cough (76.6%). Twenty-eight (43.8%) COVID-19 patients showed leukopenia, 10 (15.6%) showed lymphopenia, 47 (73.4%) and 41 (64.1%) had elevated high-sensitivity C-reactive protein (hsCRP) and erythrocyte sedimentation rate (ESR), respectively, and 30 (46.9%) had increased fibrinogen concentration. After the treatment, the counts of white blood cells and platelets, and the level of prealbumin increased significantly, while aspartate aminotransferase (AST), lactate dehydrogenase (LDH), and hsCRP decreased. COVID-19 patients with the hospital stay longer than 12 days had higher body mass index (BMI) and increased levels of AST, LDH, fibrinogen, hsCRP, and ESR. CONCLUSIONS Results of blood tests have potential clinical value in COVID-19 patients. | Please summerize the given abstract to a title |
T‐cell responses and therapies against SARS‐CoV‐2 infection | Coronavirus disease 2019 (COVID‐19) is caused by SARS‐CoV‐2, a novel coronavirus strain. Some studies suggest that COVID‐19 could be an immune‐related disease, and failure of effective immune responses in initial stages of viral infection could contribute to systemic inflammation and tissue damage, leading to worse disease outcomes. T cells can act as a double‐edge sword with both pro‐ and anti‐roles in the progression of COVID‐19. Thus, better understanding of their roles in immune responses to SARS‐CoV‐2 infection is crucial. T cells primarily react to the spike protein on the coronavirus to initiate antiviral immunity; however, T‐cell responses can be suboptimal, impaired or excessive in severe COVID‐19 patients. This review focuses on the multifaceted roles of T cells in COVID‐19 pathogenesis and rationalizes their significance in eliciting appropriate antiviral immune responses in COVID‐19 patients and unexposed individuals. In addition, we summarize the potential therapeutic approaches related to T cells to treat COVID‐19 patients. These include adoptive T‐cell therapies, vaccines activating T‐cell responses, recombinant cytokines, Th1 activators and Th17 blockers, and potential utilization of immune checkpoint inhibitors alone or in combination with anti‐inflammatory drugs to improve antiviral T‐cell responses against SARS‐CoV‐2. | Please summerize the given abstract to a title |
In Vitro Evaluation of Novel Inhibitors against the NS2B-NS3 Protease of Dengue Fever Virus Type 4 | The discovery of potent therapeutic compounds against dengue virus is urgently needed. The NS2B-NS3 protease (NS2B-NS3(pro)) of dengue fever virus carries out all enzymatic activities needed for polyprotein processing and is considered to be amenable to antiviral inhibition by analogy. Virtual screening of 300,000 compounds using Autodock 3 on the GVSS platform was conducted to identify novel inhibitors against the NS2B-NS3(pro). Thirty-six compounds were selected for in vitro assay against NS2B-NS3(pro) expressed in Pichia pastoris. Seven novel compounds were identified as inhibitors with IC(50) values of 3.9 ± 0.6–86.7 ± 3.6 μM. Three strong NS2B-NS3(pro) inhibitors were further confirmed as competitive inhibitors with K(i) values of 4.0 ± 0.4, 4.9 ± 0.3, and 3.4 ± 0.1 μM, respectively. Hydrophobic and hydrogen bond interactions between amino acid residues in the NS3(pro) active site with inhibition compounds were also identified. | Please summerize the given abstract to a title |
Colonoscopy performance correlates with scores on the FES™ manual skills test. | INTRODUCTION Achieving proficiency in flexible endoscopy is a major priority for general surgery training programs. The Fundamentals of Endoscopic Surgery (FES™) is a high-stakes examination of the knowledge and skills required to perform flexible endoscopy. The objective of this study was to establish additional evidence for the validity of the FES™ hands-on test as a measure of flexible endoscopy skills by correlating clinical colonoscopy performance with FES™ score. METHODS Participants included FES™-naïve general surgery residents, gastroenterology fellows at all levels of training and attending physicians who regularly perform colonoscopy. Each participant completed a live colonoscopy and the FES™ hands-on test within 2 weeks. Performance on live colonoscopy was measured using the Global Assessment of Gastrointestinal Endoscopic Skills-Colonoscopy (GAGES-C, maximum score 20), and performance on the FES™ hands-on test was assessed by the simulator's computerized scoring system. The clinical assessor was blinded to simulator performance. Scores were compared using Pearson's correlation coefficient. RESULTS A total of 24 participants were enrolled (mean age 30; 54 % male) with a broad range of endoscopy experience; 17 % reported no experience, 54 % had <25 previous colonoscopies; and 21 % had >100. The FES™ and GAGES scores reflected the broad range of endoscopy experience of the study group (FES™ score range 32-105; GAGES score range 5-20). Pearson's correlation coefficient between GAGES-C scores and FES™ hands-on test scores was 0.78 (0.54-0.90, p < 0.0001). All eight participants with GAGES-C score >15/20 achieved a passing score on the FES™ hands-on test. CONCLUSION There is a strong correlation between clinical colonoscopy performance and scores achieved on the FES™ hands-on test. These data support the validity of FES™ as a measure of colonoscopy skills. | Please summerize the given abstract to a title |
Primary demyelination in experimental canine distemper virus induced encephalomyelitis in gnotobiotic dogs: Sequential immunologic and morphologic findings | Experimental infection of gnotobiotic Beagle dogs at 21 days of age with neurovirulent R252 strain of canine distemper virus (R252-CDV) resulted in a non-suppurative encephalomyelitis. Segmental internodal primary demyelination was found in almost 90% of the dogs from 27 days post inoculation (DPI). Ultrastructurally demyelination was initiated by the insertion of CDV-infected astrocytic processes at nodes of Ranvier with subsequent cleavage of well-preserved myelin from the axolemma. CDV-infected macrophages were consistently involved in myelin phagocytosis. Some remyelination of denuded axons occurred after 35 DPI. Persistent productive infection of the choroid plexus and ependyma in the fourth ventricle was consistently associated with subependymal foci of demyelination. Primary demyelination occurred without detectable CDV-specific virus-neutralizing (CDV-VN) antibody in either serum or cerebrospinal fluid (CSF). There were no immunoglobulin deposits or inflammatory cells within the lesions. These findings indicate that both direct CDV antibody-dependent and CDV antibody-dependent cell-mediated immune mechanisms of cytolysis or myelin destruction are not involved in the genesis of initial primary demyelination. The sequential morphologic and serologic findings in this model of demyelinating encephalomyelitis indicate that direct virus-induced injury has a major role in both the initiation and early progression of primary demyelination. | Please summerize the given abstract to a title |
Practical handling of allergic reactions to COVID-19 vaccines | SummaryBackgroundFor the preventive treatment of the 2019 coronavirus disease (COVID-19) an unprecedented global research effort studied the safety and efficacy of new vaccine platforms that have not been previously used in humans Less than one year after the discovery of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral sequence, these vaccines were approved for use in the European Union (EU) as well as in numerous other countries and mass vaccination efforts began The so far in the EU approved mRNA vaccines BNT162b2 and mRNA-1273 are based on similar lipid-based nanoparticle carrier technologies;however, the lipid components differ Severe allergic reactions and anaphylaxis after COVID-19 vaccination are very rare adverse events but have drawn attention due to potentially lethal outcomes and have triggered a high degree of uncertainty MethodsCurrent knowledge on anaphylactic reactions to vaccines and specifically the new mRNA COVID-19 vaccines was compiled using a literature search in Medline, PubMed, as well as the national and international study and guideline registries, the Cochrane Library, and the Internet, with special reference to official websites of the World Health Organization (WHO), US Centers for Disease Control and Prevention (CDC), Robert Koch Institute (RKI), and Paul Ehrlich Institute (PEI) ResultsBased on the international literature and previous experience, recommendations for prophylaxis, diagnosis and therapy of these allergic reactions are given by a panel of experts ConclusionAllergy testing is not necessary for the vast majority of allergic patients prior to COVID-19 vaccination with currently licensed vaccines In case of allergic/anaphylactic reactions after vaccination, allergy workup is recommended, as it is for a small potential risk population prior to the first vaccination Evaluation and approval of diagnostic tests should be done for this purpose | Please summerize the given abstract to a title |
Phosphorylation of the mouse hepatitis virus nucleocapsid protein | Analysis of the radiolabeled tryptic peptides derived from the nucleocapsid proteins of two serotypes of mouse hepatitis virus showed each to have a small number of unique peptides; however, twobiologically distinct variants of the JHM strain appeared identical. Analysis of [(32)P]-labeled nucleocapsid-derived peptides showed that phosphorylation occurs at only a few sites and that all three viruses differed in the sites of phosphorylation. No differences in the sites of phosphorylation were found between the nucleocapsid proteins derived from purified virions and the membranes or the cytosol of infected cells, suggesting that post-translational phosphorylation plays no role in the regulation of viral assembly. These data show unequivocal evidence that the nucleocapsid proteins of mouse hepatitis virus strains differ in the sites of phosphorylation. | Please summerize the given abstract to a title |
Acute Exacerbations in Patients With Idiopathic Pulmonary Fibrosis | In spite of many studies, the real nature, etiology, pathobiology, and therapy of acute exacerbation (AEx) of idiopathic pulmonary fibrosis (IPF) are not clear. It seemed that AEx-IPF may be an acute acceleration of the underlying fibroproliferative process triggered by various extrinsic or unknown insults in the patients with IPF, who have a predisposition to abnormal wound healing and exaggerated fibrosis. This chapter summarizes the previous studies on etiology/triggering factors, risk factors, prognosis, and therapeutic trials with the introduction of the new consensus definition and diagnostic criteria, which remove “idiopathic” from the 2007 consensus definition, to improve the feasibility of future researches. | Please summerize the given abstract to a title |
Make Your Pitch: A Flexible Assignment for Engaging Students in Aging | Given trends in local, national, and global demographics, a need exists for educators in fields that serve older adults to provide innovative and engaging assignments that are relevant and applicable to the diverse contexts in which students are likely to find themselves as they pursue their careers. This article discusses a novel "elevator pitch" assignment that could be implemented in a number of ways to fit a variety of pedagogical methods and courses and further tailored to serve the needs of diverse student populations. For those working to actively and successfully recruit, train, and retain students in fields that serve older adults, such flexibility of assignments and delivery are likely to be acutely important as institutions, instructors, and students continue to adapt to rapidly changing developments such as those imposed by the COVID-19 pandemic. | Please summerize the given abstract to a title |
The institutional capacity of the Health Sector and the response to COVID-19 in a global perspective | This study approaches the Global Health Security Index (GHSI) according to the responses to the first cycle of the COVID-19. The GHSI ranks countries' institutional capacity to address biological risks. We analyzed data regarding the spread of COVID-19 pandemic in 50 countries to assess the ability of GHSI to anticipate health risks. The lack of vaccination determined the spread of the COVID-19 in the first cycle of the pandemic in 2020. Country indicators are correlated and demonstrated by descriptive statistics. The clustering method groups countries by similar age composition. The main restriction that can be attributed to the GHSI concerns the preference of biomedical variables for measuring institutional capacity. Our work shows that the pandemic had a significant impact on better-prepared countries, according to the GHSI, to control the spread of diseases and offer more access to health care in 2020. This paper points out that the health sector depended on the cooperation of governments in the adoption of social distancing during the first cycle of the pandemic. The GHSI failed to consider the role of political leaders who challenge severe health risks by vetoing social distancing. | Please summerize the given abstract to a title |
SARS-CoV-2 and the role of orofecal transmission: a systematic review. | BACKGROUND Modes of transmission of SARS-CoV-2 are of key public health importance. SARS-CoV-2 has been detected in the feces of some COVID-19 patients, suggesting the possibility that the virus could, in addition to droplet and fomite transmission, be transmitted via the orofecal route. METHODS This review is part of an Open Evidence Review on Transmission Dynamics of COVID-19. We conduct ongoing searches using WHO COVID-19 Database, LitCovid, medRxiv, and Google Scholar; assess study quality based on five criteria and report important findings. Where necessary, authors are contacted for further details on the content of their articles. RESULTS We include searches up until 20 December 2020. We included 110 relevant studies: 76 primary observational studies or reports, and 35 reviews (one cohort study also included a review) examining the potential role of orofecal transmission of SARS-CoV-2. Of the observational studies, 37 were done in China. A total of 48 studies (n=9,081 patients) reported single cases, case series or cohort data on individuals with COVID-19 diagnosis or their contacts and 46 (96%) detected binary RT-PCR with 535 out of 1358 samples positive for SARS-CoV-2 (average 39.4%). The results suggest a long duration of fecal shedding, often recorded after respiratory samples tested negative, and symptoms of gastrointestinal disease were reported in several studies. Twenty-nine studies reported finding SARS-CoV-2 RNA in wastewater, river water or toilet areas. Six studies attempted viral culture from COVID-19 patients' fecal samples: culture was successful in 3 of 6 studies, and one study demonstrated invasion of the virus into intestinal epithelial cells. CONCLUSIONS Varied observational and mechanistic evidence suggests SARS-CoV-2 can infect and be shed from the gastrointestinal tract, including some data demonstrating viral culture in fecal samples. To fully assess these risks, quantitative data on infectious virus in these settings and infectious dose are needed. | Please summerize the given abstract to a title |
Prospective Assessment of SARS-CoV-2 Seroconversion (PASS) study: an observational cohort study of SARS-CoV-2 infection and vaccination in healthcare workers | BACKGROUND: SARS-CoV-2 is a recently emerged pandemic coronavirus (CoV) capable of causing severe respiratory illness. However, a significant number of infected people present as asymptomatic or pauci-symptomatic. In this prospective assessment of at-risk healthcare workers (HCWs) we seek to determine whether pre-existing antibody or T cell responses to previous seasonal human coronavirus (HCoV) infections affect immunological or clinical responses to SARS-CoV-2 infection or vaccination. METHODS: A cohort of 300 healthcare workers, confirmed negative for SARS-CoV-2 exposure upon study entry, will be followed for up to 1 year with monthly serology analysis of IgM and IgG antibodies against the spike proteins of SARS-CoV-2 and the four major seasonal human coronavirus - HCoV-OC43, HCoV-HKU1, HCoV-229E, and HCoV-NL63. Participants will complete monthly questionnaires that ask about Coronavirus Disease 2019 (COVID-19) exposure risks, and a standardized, validated symptom questionnaire (scoring viral respiratory disease symptoms, intensity and severity) at least twice monthly and any day when any symptoms manifest. SARS-CoV-2 PCR testing will be performed any time participants develop symptoms consistent with COVID-19. For those individuals that seroconvert and/or test positive by SARS-CoV-2 PCR, or receive the SARS-CoV-2 vaccine, additional studies of T cell activation and cytokine production in response to SARS-CoV-2 peptide pools and analysis of Natural Killer cell numbers and function will be conducted on that participant's cryopreserved baseline peripheral blood mononuclear cells (PBMCs). Following the first year of this study we will further analyze those participants having tested positive for COVID-19, and/or having received an authorized/licensed SARS-CoV-2 vaccine, quarterly (year 2) and semi-annually (years 3 and 4) to investigate immune response longevity. DISCUSSION: This study will determine the frequency of asymptomatic and pauci-symptomatic SARS-CoV-2 infection in a cohort of at-risk healthcare workers. Baseline and longitudinal assays will determine the frequency and magnitude of anti-spike glycoprotein antibodies to the seasonal HCoV-OC43, HCoV-HKU1, HCoV-229E, and HCoV-NL63, and may inform whether pre-existing antibodies to these human coronaviruses are associated with altered COVID-19 disease course. Finally, this study will evaluate whether pre-existing immune responses to seasonal HCoVs affect the magnitude and duration of antibody and T cell responses to SARS-CoV-2 vaccination, adjusting for demographic covariates. | Please summerize the given abstract to a title |
Testing vaccines in the time of Covid: The changing landscape | The initial trials of SARS-CoV-2 vaccines were randomised control trials (RCT) with a placebo as control. The use of a placebo was ethically justified because, as with any new and emerging infectious disease, there was no known vaccine. There are now at least eight vaccines that have been shown to be effective and approved for emergency use, so the use of a placebo in the control group is no longer ethically justified. This article discusses why ethical guidelines should be continually evaluated in a changing landscape and why trust is so important. | Please summerize the given abstract to a title |
Calculating the impact of COVID-19 pandemic on child abuse and neglect in the U.S. | BACKGROUND COVID-19 has had a major impact on child abuse and neglect (CAN) in the U.S. leading to a change in the number of reported screened-in CAN investigations, missed prevention cases, and missed CAN cases. OBJECTIVES To estimate the deficit number of CAN investigations and resultant estimated number of missed prevention and CAN cases due to the COVID-19 pandemic in the U.S. from March 2020 to December 2020. METHODS Secondary data analyses of administrative child welfare data from January 2013 to December 2020 from New York City, Florida, New Jersey and Wisconsin were conducted. Spline regression modeling controlling for autocorrelation was utilized to explore any significant changes once the pandemic began in March 2020 in the number of screened-in CAN investigations. The seven-year monthly average of screen-in CAN investigations for March through December from 2013 to 2019 was calculated and compared to the numbers of CAN investigations for March 2020 to December 2020. The resultant number of missed prevention cases and CAN cases was estimated for the four jurisdictions and used to approximate the number of missed prevention cases and CAN cases in the U.S., as well as the projected estimation of national lifetime economic costs. RESULTS Prior to the pandemic, there were insignificant monthly increases of 0.7 CAN investigations in NYC and 6.2 CAN investigations in Florida, a significant monthly increase 4.2 CAN investigations in New Jersey and an insignificant monthly decrease in 0.6 CAN investigations in Wisconsin. Once the pandemic began, there were significant monthly decreases (p < .001) in each of the four jurisdictions, including 1425.6 fewer CAN investigations in NYC, 3548.0 fewer CAN investigations in Florida, 963.0 fewer CAN investigations in New Jersey and 529.1 fewer CAN investigations in Wisconsin. There were an estimated 60,791 fewer CAN investigations in these four jurisdictions from March 2020 to December 2020 of which there were approximately 18,540 missed prevention and CAN cases suggesting up to $4.2 billion in lifetime economic costs. It was estimated that were 623,137 children not investigated for CAN in the U.S. during the same 10-month period. This suggests that there were an estimated 85,993 children were missed for prevention services and about 104,040 children were missed for CAN with a potential lifetime economic impact of up to $48.1 billion in the U.S. CONCLUSIONS The COVID-19 pandemic has led to a precipitous drop in CAN investigations where almost 200,000 children are estimated to have been missed for prevention services and CAN in a 10-month period. There are opportunities for the child welfare jurisdictions to work with partner education, public health, social service and other providers to strategically approach this very grave issue in order to mitigate its impact on this very vulnerable population. | Please summerize the given abstract to a title |
Comparison of ELISA and RT-PCR versus immune electron microscopy for detection of bovine torovirus (Breda virus) in calf fecal specimens. | Bovine Torovirus (BoTV) is an uncultivable enteric pathogen of cattle. Its failure to grow in vitro limits epidemiological studies, characterization of the virus, and development of diagnostic techniques. The objectives of this study were to develop and standardize an antigen-capture enzyme-linked immunosorbent assay (ELISA) and a reverse transcriptase-polymerase chain reaction (RT-PCR) assay for the detection of BoTV in fecal specimens. These assays were compared with immunoelectron microscopy (IEM) to evaluate their sensitivity, specificity, and efficiency as well as their advantages and limitations. Additionally, several methods to calculate ELISA cutoff values were used and compared using a statistical approach to obtain the optimal cutoff value for the ELISA. A plate cutoff ELISA value was determined to be the best method to calculate the cutoff value. The ELISA and RT-PCR assays developed in this study identified BoTV antigen and viral nucleic acids in feces without cross-reactions with the other calf enteric viruses examined. Both assays showed good agreement with IEM, with a Kappa value of 0.86 for ELISA and 0.85 for RT-PCR. The latter exhibited the higher analytical sensitivity. On the basis of the results obtained in this study, it is recommended that no single test should be used alone in an epidemiological survey because of the observed limitations of each assay. The fast and inexpensive ELISA combined with the highly specific and sensitive RT-PCR are a practical approach for future epidemiological studies of BoTV. These results should provide other researchers with the information needed to develop similar diagnostic assays for the study of BoTV. | Please summerize the given abstract to a title |
COVID-19 and thermoregulation-related problems: Practical recommendations | The COVID-19 pandemic started in the cold months of the year 2020 in the Northern hemisphere. Concerns were raised that the hot season may lead to additional problems as some typical interventions to prevent heat-related illness could potentially conflict with precautions to reduce coronavirus transmission. Therefore, an international research team organized by the Global Health Heat Information Network generated an inventory of the specific concerns about this nexus and began to address the issues. Three key thermal and covid-19 related topics were highlighted: 1) For the general public, going to public cool areas in the hot season interferes with the recommendation to stay at home to reduce the spread of the virus. Conflicting advice makes it necessary to revise national heat plans and alert policymakers of this forecasted issue. 2) For medical personnel working in hot conditions, heat strain is exacerbated due to a reduction in heat loss from wearing personal protective equipment to prevent contamination. To avoid heat-related injuries, medical personnel are recommended to precool and to minimize the increase in body core temperature using adopted work/rest schedules, specific clothing systems, and by drinking cold fluids. 3) Fever, one of the main symptoms of COVID-19, may be difficult to distinguish from heat-induced hyperthermia and a resting period may be necessary prior to measurement to avoid misinterpretation. In summary, heat in combination with the COVID-19 pandemic leads to additional problems; the impact of which can be reduced by revising heat plans and implementing special measures attentive to these compound risks. | Please summerize the given abstract to a title |
Concentration of environmental fungal and bacterial bioaerosols during the monsoon season | Rain has been known to remove aerosol particles in air environments. The aerosol particles were captured and removed from the air by rain and the concentration of aerosol particles significantly decreased after rain events. Therefore, rain is regarded as having a good effect on air environments in terms of the respiratory health of the general public. However, humid environments produced by long-term rain events such a monsoon may be a sufficient condition for the growth of microorganisms and vibrations because of the splashing of droplets may facilitate the aerosolization of ground microorganisms. We therefore hypothesize that the rain may increase concentrations of bioaerosols in outdoor air environments, thereby possibly influencing respiratory diseases. To verify this hypothesis, at the initial stepwise approach, we measured the concentration of airborne biological particles before, after, and during rain in a monsoon season. The measurement data of the concentration of fungal particles and bacterial particles show quantitatively that the bioaerosol concentrations during the rain event are several times higher than the concentration of the bioaerosols in the condition of no rain. | Please summerize the given abstract to a title |
The association of chest radiographic findings and severity scoring with clinical outcomes in patients with COVID-19 presenting to the emergency department of a tertiary care hospital in Pakistan | INTRODUCTION: While chest x-rays (CXRs) represent a cost-effective imaging modality for developing countries like Pakistan, their utility for the prognostication of COVID-19 has been minimally explored. Thus, we describe the frequency and distribution of CXR findings, and their association with clinical outcomes of patients with COVID-19. METHODS: All adult (≥ 18 years) patients presenting between 28(th) February-31(st) May to the emergency department of a tertiary care hospital in Pakistan, who were COVID-19 positive on RT-PCR with CXR done on presentation, were included. A CXR Severity Score (CXR-SS) of 0–8 was used to quantify the extent of pulmonary infection on CXR, with a score of 0 being negative and 1–8 being positive. The patients’ initial CXR-SS and their highest CXR-SS over the hospital course were used for analysis, with cut-offs of 0–4 and 5–8 being used to assess association with clinical outcomes. RESULTS: A total of 150 patients, with 76.7% males and mean age 56.1 years, were included in this study. Initial CXR was positive in 80% of patients, and 30.7% of patients had an initial CXR-SS between 5–8. The mortality rate was 16.7% and 30.6% patients underwent ICU admission with intubation (ICU-Int). On multivariable analysis, initial CXR-SS (1.355 [1.136–1.616]) and highest CXR-SS (1.390 [1.143–1.690]) were predictors of ICU-Int, and ICU-Int was independently associated with both initial CXR-SS 5–8 (2.532 [1.109–5.782]) and highest CXR-SS 5–8 (3.386 [1.405–8.159]). Lastly, age (1.060 [1.009–1.113]), initial CXR-SS (1.278 [1.010–1.617]) and ICU-Int (5.047 [1.731–14.710]), were found to be independent predictors of mortality in our patients. CONCLUSION: In a resource-constrained country like Pakistan, CXRs may have valuable prognostic utility in predicting ICU admission and mortality. Additional research with larger patient samples is needed to further explore the association of CXR findings with clinical outcomes. | Please summerize the given abstract to a title |
Restarting elective surgery during the COVID-19 pandemic | In the early days of the Coronavirus disease 2019 (COVID-19) pandemic, several countries had policies to postpone elective surgical services. By reducing or suspending elective surgery, they aimed to maximize existing resources to deal with patients with COVID-19. However, the delay and/or termination of elective surgery created additional problems, both for patients and the healthcare system. Discontinuation of elective surgery can cause a risk of a backlog;increasing patient morbidity and mortality;poorer quality of life;affecting finances and hospital resources, as well as training and research programs. Based on all these considerations, elective surgery during the COVID-19 pandemic must be restarted with several requirements and provisions, which provide safety for the patients as well as the healthcare workers. The COVID-19-free pathway has been shown to minimize the risk of SARS-CoV-2 transmission in hospitals for patients undergoing elective surgery. We can use this strategy as a protocol in the future pandemics. © 2021 Faculty of Anaesthesia, Pain and Intensive Care, AFMS. All rights reserved. | Please summerize the given abstract to a title |
An In-Silico Study on Selected Organosulfur Compounds as Potential Drugs for SARS-CoV-2 Infection via Binding Multiple Drug Targets | The emerging paradigm shift from ‘one molecule, one target, for one disease’ towards ‘multi-targeted small molecules’ has paved an ingenious pathway in drug discovery in recent years This idea has been extracted for the investigation of competent drug molecules for the unprecedented COVID-19 pandemic which became the greatest global health crisis now Perceiving the importance of organosulfur compounds against SARS-CoV-2 from the drugs under clinical trials, a class of organosulfur compounds effective against SARS-CoV were selected and studied the interaction with multiple proteins of the SARS-CoV-2 One compound displayed inhibition against five proteins (both structural and non-structural) of the virus namely, main protease, papain-like protease, spike protein, helicase and RNA dependent RNA polymerase Consequently, this compound emanates as a potential candidate for treating the virulent disease The pharmacokinetics, ADMET properties and target prediction studies carried out in this work further inflamed the versatility of the compound and urge to execute iin-vitroand iin-vivoanalysis on SARS-CoV-2 in the future br | Please summerize the given abstract to a title |