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We describe 3 elderly patients with moderate to severe ataxia that occurred while they were taking propafenone. | [
{
"ade": "ataxia",
"drug": "propafenone"
}
] |
After other potential causes of liver toxicity were excluded, TMP-SMX was determined to be the cause of his acute liver toxicity. | [
{
"ade": "acute liver toxicity",
"drug": "TMP-SMX"
},
{
"ade": "liver toxicity",
"drug": "TMP-SMX"
}
] |
To our knowledge, four cases of interstitial pneumonitis associated with fludarabine have been reported in medical literature. | [
{
"ade": "interstitial pneumonitis",
"drug": "fludarabine"
}
] |
A fatal case of pancytopenia due to levomepromazine. | [
{
"ade": "fatal case of pancytopenia",
"drug": "levomepromazine"
}
] |
Early peritoneal dialysis has not previously been reported for lisinopril induced multiorgan failure. | [
{
"ade": "multiorgan failure",
"drug": "lisinopril"
}
] |
Possible pathophysiological mechanisms which may have been operative in this case include: a direct central nervous system (CNS) toxic effect of valproic acid; a paradoxical epileptogenic effect secondary to the drug; and an indirect CNS toxic effect mediated through valproic acid-induced hyperammonemia. | [
{
"ade": "hyperammonemia",
"drug": "valproic acid"
}
] |
Three years later, treatment with ampicillin caused another episode of cholestatic hepatitis with cholestasis and duct paucity on rebiopsy. | [
{
"ade": "duct paucity",
"drug": "ampicillin"
},
{
"ade": "cholestasis",
"drug": "ampicillin"
},
{
"ade": "cholestatic hepatitis",
"drug": "ampicillin"
}
] |
Herpes simplex esophagitis in a renal transplant patient treated with cyclosporine A: a case report. | [
{
"ade": "Herpes simplex esophagitis",
"drug": "cyclosporine A"
}
] |
Nitrendipine is an experimental calcium channel blocking agent that also appears to cause the side effect of drug-induced gingival hyperplasia. | [
{
"ade": "gingival hyperplasia",
"drug": "Nitrendipine"
}
] |
His fever resolved, but he developed symptoms consistent with those of chloroquine toxicity. | [
{
"ade": "chloroquine toxicity",
"drug": "chloroquine"
}
] |
A 70-year-old man was admitted to our hospital because of dyspnea after taking an antihistaminic agent (homochlorcyclizine hydrochloride) for itching. | [
{
"ade": "dyspnea",
"drug": "homochlorcyclizine hydrochloride"
}
] |
Fixed drug eruption to rofecoxib. | [
{
"ade": "Fixed drug eruption",
"drug": "rofecoxib"
}
] |
Iatrogenic hypercalcemia due to vitamin D3 ointment (1,24(OH)2D3) combined with thiazide diuretics in a case of psoriasis. | [
{
"ade": "hypercalcemia",
"drug": "thiazide"
},
{
"ade": "hypercalcemia",
"drug": "1,24(OH)2D3"
},
{
"ade": "hypercalcemia",
"drug": "vitamin D3"
}
] |
Bromide intoxication secondary to pyridostigmine bromide therapy. | [
{
"ade": "Bromide intoxication",
"drug": "pyridostigmine bromide"
}
] |
A 67-year-old man developed diarrhea shortly after a 10-day course of oral ampicillin. | [
{
"ade": "diarrhea",
"drug": "ampicillin"
}
] |
Pleuropulmonary changes during treatment of Parkinson's disease with a long-acting ergot derivative, cabergoline. | [
{
"ade": "Pleuropulmonary changes",
"drug": "cabergoline"
}
] |
Symptoms and endoscopic lesions quickly regressed within 1 week of meloxicam withdrawal. | [
{
"ade": "endoscopic lesions",
"drug": "meloxicam"
}
] |
Mineral oil, a hydrocarbon, may not elicit a normal protective cough reflex and may impair mucociliary transport. | [
{
"ade": "impair mucociliary transport",
"drug": "Mineral oil"
}
] |
IFNalpha-induced recurrence of Graves' disease ten years after thyroidectomy in chronic viral hepatitis C. | [
{
"ade": "Graves' disease",
"drug": "IFNalpha"
}
] |
The three reported cases demonstrate that troglitazone is an idiosyncratic hepatotoxin that can lead to irreversible liver injury. | [
{
"ade": "irreversible liver injury",
"drug": "troglitazone"
}
] |
SLE receded after withdrawal of carbamazepine and treatment with anti-inflammatory drugs. | [
{
"ade": "SLE",
"drug": "carbamazepine"
}
] |
Conventional and diffusion-weighted MRI findings of methotrexate related sub-acute neurotoxicity. | [
{
"ade": "sub-acute neurotoxicity",
"drug": "methotrexate"
}
] |
Elevated serum triglycerides with clozapine resolved with risperidone in four patients. | [
{
"ade": "Elevated serum triglycerides",
"drug": "clozapine"
}
] |
Thrombocytosis associated with enoxaparin: A very rare cause in newborns. | [
{
"ade": "Thrombocytosis",
"drug": "enoxaparin"
}
] |
The aim of this paper is to report the case of rosaceiform eruption induced by erlotinib in an 81-year-old-man and to discuss the pathogenetic role of Demodex folliculorum mites, found in the present patient, using skin scraping. | [
{
"ade": "rosaceiform eruption",
"drug": "erlotinib"
}
] |
PURPOSE: The occurrence of myoclonus associated with continuous i.v. infusion of dobutamine in a patient with end-stage renal disease (ESRD) is described. | [
{
"ade": "myoclonus",
"drug": "dobutamine"
}
] |
We report one case of non-Hodgkin lymphoma in a patient, with a 30-year history of rheumatoid arthritis, taking low dose methotrexate weekly over a 10-month period. | [
{
"ade": "non-Hodgkin lymphoma",
"drug": "methotrexate"
}
] |
After taking cholestyramine II sachets twice daily for two months she presented with lethargy, confusion and drowsiness. | [
{
"ade": "lethargy",
"drug": "cholestyramine II"
},
{
"ade": "confusion",
"drug": "cholestyramine II"
},
{
"ade": "drowsiness",
"drug": "cholestyramine II"
}
] |
Based on the clinical status of the patient, it was suspected that several conditions contributed to the abnormal hypersensitivity to warfarin. | [
{
"ade": "abnormal hypersensitivity",
"drug": "warfarin"
}
] |
Flecainide is a rare cause of hypersensitivity pneumonitis, and few cases have been reported. | [
{
"ade": "hypersensitivity pneumonitis",
"drug": "Flecainide"
}
] |
We hypothesize that capecitabine-induced headache is vascular in nature. | [
{
"ade": "headache",
"drug": "capecitabine"
}
] |
Our findings suggest that significant progression of marrow reticulin fibrosis during imatinib therapy can be an indicator for a return or progression of CML and, in some patients with CML, imatinib may promote cytogenetic clonal evolution, resulting in a poor response to treatment. | [
{
"ade": "progression of marrow reticulin fibrosis",
"drug": "imatinib"
}
] |
The case of a bipolar patient who developed thyrotoxicosis with severe exophthalmos while on lithium therapy is described. | [
{
"ade": "thyrotoxicosis",
"drug": "lithium"
},
{
"ade": "severe exophthalmos",
"drug": "lithium"
}
] |
A dapsone hypersensitivity syndrome, consisting of fever, headache, nausea, vomiting, lymphadenopathy, hepatitis, hemolysis, leukopenia, and mononucleosis, has been described in patients treated with the drug for leprosy. | [
{
"ade": "hepatitis",
"drug": "dapsone"
},
{
"ade": "lymphadenopathy",
"drug": "dapsone"
},
{
"ade": "vomiting",
"drug": "dapsone"
},
{
"ade": "nausea",
"drug": "dapsone"
},
{
"ade": "leukopenia",
"drug": "dapsone"
},
{
"ade": "fever",
"drug": "dapsone"
},
{
"ade": "mononucleosis",
"drug": "dapsone"
},
{
"ade": "headache",
"drug": "dapsone"
},
{
"ade": "hemolysis",
"drug": "dapsone"
},
{
"ade": "hypersensitivity syndrome",
"drug": "dapsone"
}
] |
Although vasculitis has been reported in the course of hairy cell leukaemia, it has only rarely been reported as the consequence of cladribine treatment. | [
{
"ade": "vasculitis",
"drug": "cladribine"
}
] |
FK506, which began to be administered 12 days earlier, rose to a level of 44 ng/mL (normal range, 10-20 ng/mL) 1 day before neurologic abnormalities began. | [
{
"ade": "neurologic abnormalities",
"drug": "FK506"
}
] |
Vincristine induced cranial polyneuropathy. | [
{
"ade": "cranial polyneuropathy",
"drug": "Vincristine"
}
] |
The other patient developed transient intraoperative hypertension immediately after inadvertent submucosal injection of concentrated epinephrine. | [
{
"ade": "transient intraoperative hypertension",
"drug": "epinephrine"
}
] |
The association between heparin and priapism is often recognized; abnormal platelet aggregation could play a role in the pathogenesis of this side effect. | [
{
"ade": "priapism",
"drug": "heparin"
},
{
"ade": "abnormal platelet aggregation",
"drug": "heparin"
}
] |
A 55-yr-old man developed prolonged jaundice and sicca complex after a course of thiabendazole therapy. | [
{
"ade": "sicca complex",
"drug": "thiabendazole"
},
{
"ade": "prolonged jaundice",
"drug": "thiabendazole"
}
] |
Bulbar and pseudobulbar palsy complicating therapy with high-dose cytosine arabinoside in children with leukemia. | [
{
"ade": "Bulbar",
"drug": "cytosine arabinoside"
},
{
"ade": "pseudobulbar palsy",
"drug": "cytosine arabinoside"
}
] |
Hepatotoxicity of paracetamol enhanced by ingestion of alcohol: report of two cases. | [
{
"ade": "Hepatotoxicity",
"drug": "paracetamol"
}
] |
Diffuse alveolar hemorrhage after leflunomide therapy in a patient with rheumatoid arthritis. | [
{
"ade": "Diffuse alveolar hemorrhage",
"drug": "leflunomide"
}
] |
De novo absence status of late onset following withdrawal of lorazepam: a case report. | [
{
"ade": "De novo absence status",
"drug": "lorazepam"
}
] |
Hepatotoxicity after high-dose methylprednisolone for demyelinating disease. | [
{
"ade": "Hepatotoxicity",
"drug": "methylprednisolone"
}
] |
Fulminant hepatic failure is a rare complication of disulfiram treatment for alcoholism. | [
{
"ade": "Fulminant hepatic failure",
"drug": "disulfiram"
}
] |
We now present four cases of RSDS in kidney transplant recipients treated with tacrolimus. | [
{
"ade": "RSDS",
"drug": "tacrolimus"
}
] |
Ciprofloxacin-induced renal insufficiency in cystic fibrosis. | [
{
"ade": "renal insufficiency",
"drug": "Ciprofloxacin"
}
] |
Reinstitution of penicillamine treatment caused a recurrence thus proving a causal relationship between penicillamine and the described nail-changes. | [
{
"ade": "nail-changes",
"drug": "penicillamine"
}
] |
Two cases of hypothyroidism in patients with chronic hepatitis C treated with recombinant alpha interferon are reported. | [
{
"ade": "hypothyroidism",
"drug": "recombinant alpha interferon"
}
] |
Niacin causes a reversible toxic cystoid maculopathy that occurs in approximately 0.67% of patients taking high doses of the drug. | [
{
"ade": "reversible toxic cystoid maculopathy",
"drug": "Niacin"
}
] |
Docetaxel induced Meibomian duct inflammation and blockage is the likely cause of this presentation in a patient with no history of eyelid masses in the past. | [
{
"ade": "Meibomian duct inflammation and blockage",
"drug": "Docetaxel"
}
] |
The hypercalcemia responded to discontinuation of rhGH and a single dose of intravenous pamidronate disodium and has not recurred in 8 months of follow-up. | [
{
"ade": "hypercalcemia",
"drug": "rhGH"
}
] |
Disseminated muscular cysticercosis with myositis induced by praziquantel therapy. | [
{
"ade": "myositis",
"drug": "praziquantel"
}
] |
Colchicine-induced myopathy in renal failure. | [
{
"ade": "myopathy",
"drug": "Colchicine"
}
] |
Ifosfamide-induced nonconvulsive status epilepticus. | [
{
"ade": "nonconvulsive status epilepticus",
"drug": "Ifosfamide"
}
] |
The photosensitivity is still present 3 years after the withdrawal of quinine. | [
{
"ade": "photosensitivity",
"drug": "quinine"
}
] |
To date, only three cases of seizures associated with amphotericin B have been reported in the literature, but healthcare providers should be aware of the potential for this rare adverse effect. | [
{
"ade": "seizures",
"drug": "amphotericin B"
}
] |
Reversal of ergotamine-induced arteriospasm by mechanical intra-arterial dilatation. | [
{
"ade": "arteriospasm",
"drug": "ergotamine"
}
] |
RESULTS: A clinical diagnosis of fixed drug eruption owing to use of the PDE5 inhibitor tadalafil (Cialis) was made. | [
{
"ade": "fixed drug eruption",
"drug": "tadalafil"
},
{
"ade": "fixed drug eruption",
"drug": "Cialis"
}
] |
Stupor from lamotrigine toxicity. | [
{
"ade": "Stupor",
"drug": "lamotrigine"
}
] |
Carbamazepine-induced tics. | [
{
"ade": "tics",
"drug": "Carbamazepine"
}
] |
The capacity of zuclopenthixol to induce priapism is thought to be due to its antagonist activity on alpha-adrenergic receptors. | [
{
"ade": "priapism",
"drug": "zuclopenthixol"
}
] |
Triiodothyronine-induced thyrotoxicosis in ophthalmic Graves disease. | [
{
"ade": "thyrotoxicosis",
"drug": "Triiodothyronine"
}
] |
The spectrum of renal lesions occurring during antituberculous therapy, particularly in association with rifampin, may be wider than previously suspected. | [
{
"ade": "renal lesions",
"drug": "rifampin"
}
] |
Successful desensitization to high-dose methotrexate after systemic anaphylaxis. | [
{
"ade": "systemic anaphylaxis",
"drug": "methotrexate"
}
] |
Succinylcholine-induced hyperkalemia in a patient with mucositis secondary to chemotherapy. | [
{
"ade": "hyperkalemia",
"drug": "Succinylcholine"
}
] |
Angioedema, a rare side effect of carbamazepine, involves vascular leakage in dermis and subcutis mediated by immunoglobulin E and/or bradykinins. | [
{
"ade": "Angioedema",
"drug": "carbamazepine"
}
] |
This case is remarkable since 1) ECM developed after subcutaneous and not after intramuscular injection, 2) the injection was given by the patient himself, and 3) glatiramer acetate can induce skin necrosis as a side effect. | [
{
"ade": "skin necrosis",
"drug": "glatiramer acetate"
}
] |
In two patients clozapine was reinstated after risperidone was discontinued; serum triglyceride levels increased. | [
{
"ade": "serum triglyceride levels increased",
"drug": "clozapine"
}
] |
We recommend the cautious use of ketorolac in patients with underlying illnesses where NSAID-induced ototoxicity could result in adverse otologic consequences. | [
{
"ade": "ototoxicity",
"drug": "ketorolac"
}
] |
Children receiving zonisamide should be monitored for oligohidrosis and the development of neurological symptoms associated with an elevation of body temperature. | [
{
"ade": "neurological symptoms",
"drug": "zonisamide"
},
{
"ade": "oligohidrosis",
"drug": "zonisamide"
}
] |
Administration of intrathecal Ara-C in the same dose over longer intervals within 3-5 days between consecutive doses resulted in mild, transient neurological symptoms (paresthesias) in only one of 30 patients so treated. | [
{
"ade": "paresthesias",
"drug": "Ara-C"
}
] |
It is well-recognized that flucloxacillin may occasionally result in fatal hepatic injury. | [
{
"ade": "fatal hepatic injury",
"drug": "flucloxacillin"
}
] |
Upper tract urothelial malignancy after cyclophosphamide therapy: a case report and literature review. | [
{
"ade": "Upper tract urothelial malignancy",
"drug": "cyclophosphamide"
}
] |
Hypoglycemia can be a serious side effect of etanercept in patients already on antidiabetic medications known to cause hypoglycemia, such as sulfonylureas, meglitinides, and insulin. | [
{
"ade": "hypoglycemia",
"drug": "insulin"
},
{
"ade": "hypoglycemia",
"drug": "etanercept"
},
{
"ade": "Hypoglycemia",
"drug": "etanercept"
},
{
"ade": "hypoglycemia",
"drug": "meglitinides"
},
{
"ade": "hypoglycemia",
"drug": "sulfonylureas"
}
] |
Nicotinic acid-induced fulminant hepatic failure. | [
{
"ade": "fulminant hepatic failure",
"drug": "Nicotinic acid"
}
] |
We report a patient with pulmonary adenocarcinoma complicated by the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) following systemic chemotherapy with cisplatin (CDDP) and vindesine (VDS). | [
{
"ade": "syndrome of inappropriate secretion of antidiuretic hormone",
"drug": "cisplatin"
},
{
"ade": "SIADH",
"drug": "vindesine"
},
{
"ade": "syndrome of inappropriate secretion of antidiuretic hormone",
"drug": "CDDP"
},
{
"ade": "SIADH",
"drug": "CDDP"
},
{
"ade": "syndrome of inappropriate secretion of antidiuretic hormone",
"drug": "vindesine"
},
{
"ade": "SIADH",
"drug": "cisplatin"
},
{
"ade": "SIADH",
"drug": "VDS"
},
{
"ade": "syndrome of inappropriate secretion of antidiuretic hormone",
"drug": "VDS"
}
] |
Hepatic reactions to cyclofenil. | [
{
"ade": "Hepatic reactions",
"drug": "cyclofenil"
}
] |
Physicians should be aware that indinavir nephrolithiasis may cause papillary necrosis. | [
{
"ade": "nephrolithiasis",
"drug": "indinavir"
},
{
"ade": "papillary necrosis",
"drug": "indinavir"
}
] |
Treatment of chronic hepatitis C with interferon alpha (IFN-alpha) is relatively contraindicated in patients with psychiatric disorders because of possible severe psychiatric side effects. | [
{
"ade": "psychiatric side effects",
"drug": "interferon alpha"
},
{
"ade": "psychiatric side effects",
"drug": "IFN-alpha"
}
] |
Anaphylactic reaction to bacitracin ointment. | [
{
"ade": "Anaphylactic reaction",
"drug": "bacitracin"
}
] |
Flecainide overdose can rapidly result in profound cardiovascular collapse, and is associated with a relatively high mortality. | [
{
"ade": "cardiovascular collapse",
"drug": "Flecainide"
}
] |
D-penicillamine induced crescentic glomerulonephritis: report and review of the literature. | [
{
"ade": "crescentic glomerulonephritis",
"drug": "D-penicillamine"
}
] |
Fever caused by the use of furosemide was proved; the fever resolved after discontinuation of this medication and recurred after its reintroduction. | [
{
"ade": "Fever",
"drug": "furosemide"
}
] |
While undergoing treatment with albendazole, he developed worsening diarrhea with abdominal pain and fever. | [
{
"ade": "abdominal pain",
"drug": "albendazole"
},
{
"ade": "worsening diarrhea",
"drug": "albendazole"
},
{
"ade": "fever",
"drug": "albendazole"
}
] |
STUDY DESIGN: Case reports are presented of three premature infants (mean gestational age 27 weeks) cared for in the intensive care nursery in whom clinically significant septal hypertrophy and left ventricular outflow tract obstruction developed during dexamethasone treatment for bronchopulmonary dysplasia. | [
{
"ade": "septal hypertrophy",
"drug": "dexamethasone"
},
{
"ade": "left ventricular outflow tract obstruction",
"drug": "dexamethasone"
}
] |
Adrenal suppression in a fetus due to administration of methylprednisolone has hitherto been rarely published. | [
{
"ade": "Adrenal suppression in a fetus",
"drug": "methylprednisolone"
}
] |
CONCLUSION: Significant ocular complications such as an irreversible decrease of visual acuity may develop in patients treated with pegylated interferon. | [
{
"ade": "ocular complications",
"drug": "pegylated interferon"
},
{
"ade": "irreversible decrease of visual acuity",
"drug": "pegylated interferon"
}
] |
OBJECTIVE: To present a single case of zuclopenthixol-induced priapism and a literature review. | [
{
"ade": "priapism",
"drug": "zuclopenthixol"
}
] |
We describe a patient who had a systemic allergic contact dermatitis to 8-MOP develop during her second course of PUVA treatment for psoriasis. | [
{
"ade": "systemic allergic contact dermatitis",
"drug": "8-MOP"
}
] |
Vitiligo associated with alpha-interferon in a patient with chronic active hepatitis C. | [
{
"ade": "Vitiligo",
"drug": "alpha-interferon"
}
] |
The risk of cardiac decompensation in infants with supraventricular tachycardia and congestive cardiac failure should be kept in mind prior to administration of verapamil. | [
{
"ade": "cardiac decompensation",
"drug": "verapamil"
}
] |
On day 7 of linezolid treatment, the patient developed severe pruritus, macular rash, facial edema, eosinophilia, marked increase in serum creatinine level, and mild hepatitis. | [
{
"ade": "facial edema",
"drug": "linezolid"
},
{
"ade": "marked increase in serum creatinine level",
"drug": "linezolid"
},
{
"ade": "eosinophilia",
"drug": "linezolid"
},
{
"ade": "severe pruritus",
"drug": "linezolid"
},
{
"ade": "mild hepatitis",
"drug": "linezolid"
},
{
"ade": "macular rash",
"drug": "linezolid"
}
] |
Delayed neurotoxicity of intraventricular interleukin-2: a case report. | [
{
"ade": "neurotoxicity",
"drug": "interleukin-2"
}
] |
The second patient, who developed cholestasis after receiving trimethoprim-sulfamethoxazole, had marked duct paucity in the liver biopsy. | [
{
"ade": "duct paucity",
"drug": "trimethoprim-sulfamethoxazole"
},
{
"ade": "cholestasis",
"drug": "trimethoprim-sulfamethoxazole"
}
] |
Ten hours after the second methotrexate injection, the patient experienced a diffuse pruritic papular eruption located mainly on the limbs. | [
{
"ade": "diffuse pruritic papular eruption",
"drug": "methotrexate"
}
] |
An association of granulocytopenia, eosinophilia, skin reaction and hepatitis during propylthiouracil (PTU) therapy for thyrotoxicosis in a 47 year old black female is reported. | [
{
"ade": "hepatitis",
"drug": "PTU"
},
{
"ade": "eosinophilia",
"drug": "propylthiouracil"
},
{
"ade": "hepatitis",
"drug": "propylthiouracil"
},
{
"ade": "granulocytopenia",
"drug": "PTU"
},
{
"ade": "skin reaction",
"drug": "propylthiouracil"
},
{
"ade": "granulocytopenia",
"drug": "propylthiouracil"
},
{
"ade": "skin reaction",
"drug": "PTU"
},
{
"ade": "eosinophilia",
"drug": "PTU"
}
] |
Prolongation of the QT interval and ventricular tachyarrhymias have been described in patients on amiodarone therapy. | [
{
"ade": "Prolongation of the QT interval",
"drug": "amiodarone"
},
{
"ade": "ventricular tachyarrhymias",
"drug": "amiodarone"
}
] |
We report a case of Ritalin-associated cataract and glaucoma. | [
{
"ade": "cataract",
"drug": "Ritalin"
},
{
"ade": "glaucoma",
"drug": "Ritalin"
}
] |
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