Datasets:

habdine

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Prot2Text-Data

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Q6GL39

WDR82_XENTR

WD repeat-containing protein 82

Silurana

MKLTDNVLRSFRVAKVFRENSDKINCFDFSPTGETVISSSDDDSIVLYDCQEGKPKRTLYSKKYGVDLIRYTHAANTVVYSSNKIDDTIRYLSLHDNKYIRYFPGHSKRVVALSMSPVDDTFISGSLDKTIRLWDLRSPNCQGLMHLQGKPVCSFDPEGLIFAAGVNSEMVKLYDLRSFDKGPFATFKMQYDRTCEWTALKFSNDGKLILMSTNGGFLRLVDAFKGAVMHTFGGYNNSKAVTLEATFTPDSQFIMIGSEDGKIHVWNCESGMKVAVLDGKHTGPITCLQFNPKFMTFTSACSNMAFWLPTIDD

Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 'Lys-4' methylation (H3K4me) via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Part of a transcription termination checkpoint that promotes transcription termination of long non-coding RNAs (lncRNAs).

Q6GL39

P37752

TRMO_EIKCO

tRNA methyltransferase O

Eikenella

SFSHIWVQFVFHGVAGAGWQPLVRPPRLGGNRKMGVFATRSPFRPNPLGLSLLKLERIETEGGVRLWCGGADLLDGTPVLDIKPYLPFVEAQPDAAPGFAAVPPVPLEVAWADEISAASLPPPNRLLIEQSIAQDPRPAYQDTPQRVYKMAVDDWEVAFRIEKGMALIEAVMAVEG

S-adenosyl-L-methionine-dependent methyltransferase responsible for the addition of the methyl group in the formation of N6-methyl-N6-threonylcarbamoyladenosine at position 37 (m(6)t(6)A37) of the tRNA anticodon loop of tRNA(Thr)(GGU). The methyl group of m(6)t(6)A37 appears to slightly improve the efficiency of the tRNA decoding ability. Binds to tRNA.

P37752

P05483

U7AB_CONGE

Shaker peptides GVIIA/GVIIB

Gastridium

CKSPGTPCSRGMRDCCTSCLLYSNKCRRY

Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav).

P05483

P29962

Y1784_RHOCB

ORF124

Rhodobacter

MAPREPGFAGALPIDGYGPGFFRIAGAVHRGGLLIHAEAAMPWTGFDDLAALRALAGQVDLLLCGMGADIAHLPKGLQVELEALGVMAEPMSTASAARHYNVLLSEGRRVGAALLPMPGAVPTA

Not required for the biogenesis of c-type cytochromes.

P29962

Q13454

TUSC3_HUMAN

Protein N33

Homo

MGARGAPSRRRQAGRRLRYLPTGSFPFLLLLLLLCIQLGGGQKKKENLLAEKVEQLMEWSSRRSIFRMNGDKFRKFIKAPPRNYSMIVMFTALQPQRQCSVCRQANEEYQILANSWRYSSAFCNKLFFSMVDYDEGTDVFQQLNMNSAPTFMHFPPKGRPKRADTFDLQRIGFAAEQLAKWIADRTDVHIRVFRPPNYSGTIALALLVSLVGGLLYLRRNNLEFIYNKTGWAMVSLCIVFAMTSGQMWNHIRGPPYAHKNPHNGQVSYIHGSSQAQFVAESHIILVLNAAITMGMVLLNEAATSKGDVGKRRIICLVGLGLVVFFFSFLLSIFRSKYHGYPYSDLDFE

Magnesium transporter.

Q13454

Q88W46

TARI_LACPL

Ribitol-5-phosphate cytidylyltransferase

Lactiplantibacillus

MIYAQILAGGKGTRMGNVPMPKQFLLLADKPILIHTIEKFTLESRFDAILVVCPADWVSHTEDIIKKYITDERVHVVVGGADRNETLMSGINYIQDHYGIQDDDVVVTHDAVRPFITQRIINDNIVAVLENKAVDTVVPAIDTIVRGANDQVTDIPVRSEMYQGQTPQSFHIKILIDSYNALSSEQKASLSDSCKICSLAGQKVSLVRGENYNFKITTPFDLRVASALVEKRS

Catalyzes the transfer of the cytidylyl group of CTP to D-ribitol 5-phosphate.

Q88W46

B3CU37

YQGF_ORITI

Putative pre-16S rRNA nuclease

Orientia

MIINSIIEFLQAADIKKQILGIDFGEKKVGVAISNIEHTVAMPLQTIFATNQDRINKIQEIAVAYNIGAIVIGLPFKLDGTETSQTHRVKDFANKLANKLLLPIFLCDERLTSKAANNLLKMGNIKRKVRNAIDDRVAASIILEGTLKRMQNSKSYF

Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.

B3CU37

P29037

TBP_MOUSE

Transcription initiation factor TFIID TBP subunit

Mus

MDQNNSLPPYAQGLASPQGAMTPGIPIFSPMMPYGTGLTPQPIQNTNSLSILEEQQRQQQQQQQQQQQQQAVATAAASVQQSTSQQPTQGASGQTPQLFHSQTLTTAPLPGTTPLYPSPMTPMTPITPATPASESSGIVPQLQNIVSTVNLGCKLDLKTIALRARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVVQKLGFPAKFLDFKIQNMVGSCDVKFPIRLEGLVLTHQQFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRAEIYEAFENIYPILKGFRKTT

General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of a BRF2-containing transcription factor complex that regulates transcription mediated by RNA polymerase III. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA.

P29037

O74000

Y106A_PYRHO

Putative antitoxin PH1062.1

Pyrococcus

MSKTITIADDVYYELVKMKGKRSFSEVLRELIGKKKEGNLDVLMIAFGTMDEEEAKELEEKIKEVGKWLNSWTPV

Possibly the antitoxin component of a type II toxin-antitoxin (TA) system.

O74000

B1LE44

YDIB_ECOSM

NAD-dependent shikimate 5-dehydrogenase

Escherichia

MNVTAKYELIGLMAYPIRHSLSPEMQNKALEKAGLPFTYMAFEVDNDSFPAAIEGLKALKMRGTGVSMPNKQLACEYVDELTPAAKLVGAINTIVNDDGYLRGYNTDGTGHIRAIKESGFDIKGKTMVLLGAGGASTAIGAQGAIEGLKEIKLFNRRDEFFDKALAFAQRVNENTDCVVTVTDLADQQAFAEALASADILTNGTKVGMKPLENESLVHDISLLHPGLLVTECVYNPHMTKLLQQAQQAGCKTIDGYGMLLWQGAEQFTLWTGKDFPLEYVKQVMGFGA

The actual biological function of YdiB remains unclear, nor is it known whether 3-dehydroshikimate or quinate represents the natural substrate. Catalyzes the reversible NAD-dependent reduction of both 3-dehydroshikimate (DHSA) and 3-dehydroquinate to yield shikimate (SA) and quinate, respectively. It can use both NAD or NADP for catalysis, however it has higher catalytic efficiency with NAD.

B1LE44

B2I7H1

TTCA_XYLF2

tRNA 2-thiocytidine biosynthesis protein TtcA

Xylella

MDATFPSQHNITARPAPGRIRREQCKLAKRLRRQVGQAIADFGMIEANDKIMVCLSGGKDSYTLLDMLLQLRAKAPVPFELTAVNLDQKQPGFPKHVLPEYLSSIGVPYHIIEQDTYSVVTRVVPEGKTLCALCSRMRRGALYAYAETQGFTKIALGHHRDDMVATFFMNLFHHAKLSGMPPKLRSDNGKHVVIRPLAYVSETDIIAYADAREFPIIPCNLCGSQENLQRKQVGVMLKAWEKEYPGRIEQIARALGNIRPSQLADQSLFDFLALGRHSNTPLPNAHAWLAGDLANDTAP

Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.

B2I7H1

Q4V7R0

TIGAR_XENLA

TP53-induced glycolysis and apoptosis regulator

Xenopus

MARFALTIVRHGETRYNKEKLLQGQGIDEPLSEMGFKQADAAGRFLSNVRFTHVFSSDLIRAKQTACAIMRNNQLSEDIKIMYDPRLRERKYGDAEGRPLSELKVMAKKAGGQCPSYTPPGGETLEQVRACAKDFFEYLCQLVMAESSVKEKSELGASGMVGIMSTDLAPFVNHNKEPTIFGESRDVTLDASVLLVSHGAYMRNWIKYFVEDLQFTFPPELKKSRELSVSPNTGISHFIVTVGSGATRKPEIQCVCINLHGHLSDIDADTSHYQV

Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate. Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6-bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production. Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death. May play a role in mitophagy inhibition.

Q4V7R0

Q28K11

TRUB_JANSC

tRNA-uridine isomerase

unclassified Jannaschia

MARRNKGRDISGWVLVDKPAGLTSTAVVNKVRWCFDAKKAGHAGTLDPDATGMLPVALGEATKTIAYMSDDLKAYTFRVRLGVSTKTDDAEGEVLETSDTRPTDTEIEAALPAFVGDIQQVPPQFSAVKVDGERAYDIARGGGEMELAARDLYVESLSVIGRPDADHVDLEFVCGSGGYVRSIARDLGQVLGCFGHVLWLRRTWVGAFDIEDAVGLDRVEALARTDALYALLQPVGLALHALPELRVTDAGAARLRNGNPGGVLPGNVEYGDLAWASLNGTPVAVGRYRSGELHPERVFNL

Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

Q28K11

Q984P3

UVRC_RHILO

Excinuclease ABC subunit C

Mesorhizobium

MSPLDQKNKPRGGADDLPPEIDLEDEALEEIVEPTGPDVAFTAIDWTPHAGDAEGMVGAEVIQTLVKRLPNAPGVYRMMNAAGDVLYVGKARSLKKRVTNYAQGRFHTNRIGRMVRETSTMEFVVTRTEIEALLLEANLIKRLRPRFNVLMRDDKSFPYILLTGDHVSPGIYKHRGARSRKGDYFGPFASAGAVGRTINSLQRAFLLRSCTNSFYENRTRPCLLYQIKRCAGPCTGEISHEGYAELVAEAKDFLSGRSQKVKTEISAAMQQASEDLDFERAAIYRDRLAALSHVQSHQGINPATVDEADVFAIHQEGGQVCIQVFFFRTGQNWGNRAYFPKADPALEAAEVLGSFLAQFYDDKPTPRNILLSRGVEDQELLGEALSTRAGRKVTISVPQRGEKKDLTDNALQNAREALGRRLAETSTQGRLLAGFAETFGLAKPPVRIEVYDNSHIMGTNAVGAMVVAGPEGFVKNQYRKFNIRSTEITPGDDFGMMREVMERRFSRLLKEHGDVAPNDAASAEAGDDIEDDISGSFPAWPDVILIDGGQGQMTAVRKILADLGIEDRVVAIGIAKGQDRDAGRERFFVKGRDSFSLPVRDPVLYFVQRLRDEVHRFAIGSHRARRKKEMVKSPLDEIAGIGPGRKRALLLAFGTAKAVSRAAIEDLRKVDGISEQVAKLVYNHFHES

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

Q984P3

Q5NYM6

YCIB_AROAE

Inner membrane-spanning protein YciB

Aromatoleum

MKILFDLLPVILFFVAYKIAGGNQAFAHELASRWLGDGIAVTQAPILLATAVAILATIAQIGWVWMRHRKVDTMLWISLAIIAVFGGATLFFHNPTFIKWKPTALYWLFGGTLTVSAVIFRRNLIRKMLEAQIRLPEPVWKRLNLAWAGFFILMGFLNLYVAYNFSEEAWVNFKLFGGMGLMLLFVLGQGFYLSRHIQEETT

Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.

Q5NYM6

Q641Q2

WAC2A_HUMAN

WASH complex subunit 2A

Homo

MMNRTTPDQELAPASEPVWERPWSVEEIRRSSQSWSLAADAGLLQFLQEFSQQTISRTHEIKKQVDGLIRETKATDCRLHNVFNDFLMLSNTQFIENRVYDEEVEEPVLKAEAEKTEQEKTREQKEVDLIPKVQEAVNYGLQVLDSAFEQLDIKAGNSDSEEDDANGRVELILEPKDLYIDRPLPYLIGSKLFMEQEDVGLGELSSEEGSVGSDRGSIVDTEEEKEEEESDEDFAHHSDNEQNRHTTQMSDEEEDDDGCDLFADSEKEEEDIEDIEENTRPKRSRPTSFADELAARIKGDAVGRVDEEPTTLPSGEAKPRKTLKEKKERRTPSDDEEDNLFAPPKLTDEDFSPFGSGGGLFSGGKGLFDDEDEESDLFTEAPQDRQAGASVKEESSSSKPGKKIPAGAVSVFLGDTDVFGAASVPSMKEPQKPEQPTPRKSPYGPPPTGLFDDDDGDDDDDFFSAPHSKPSKTGKVQSTADIFGDEEGDLFKEKAVASPEATVSQTDENKARAEKKVTLSSSKNLKPSSETKTQKGLFSDEEDSEDLFSSQSASKLKGASLLPGKLPTLVSLFDDEDEEDNLFGGTAAKKQTLCLQAQREEKAKASELSKKKASALLFSSDEEDQWNIPASQTHLASDSRSKGEPRDSGTLQSQEAKAVKKTSLFEEDEEDDLFAIAKDSQKKTQRVSLLFEDDVDSGGSLFGSPPTSVPPATKKKETVSEAPPLLFSDEEEKEAQLGVKSVDKKVESAKESLKFGRTDVAESEKEGLLTRSAQETVKHSDLFSSSSPWDKGTKPRTKTVLSLFDEEEDKMEDQNIIQAPQKEVGKGRDPDAHPKSTGVFQDEELLFSHKLQKDNDPDVDLFAGTKKTKLLEPSVGSLFGDDEDDDLFSSAKSQPLVQEKKRVVKKDHSVDSFKNQKHPESIQGSKEKGIWKPETPQDSSGLAPFKTKEPSTRIGKIQANLAINPAALLPTAASQISEVKPVLPELAFPSSEHRRSHGLESVPVLPGSGEAGVSFDLPAQADTLHSANKSRVKMRGKRRPQTRAARRLAAQESSETEDMSVPRGPIAQWADGAISPNGHRPQLRAASGEDSTEEALAAAAAPWEGGPVPGVDRSPFAKSLGHSRGEADLFDSGDIFSTGTGSQSVERTKPKAKIAENPANPPVGGKAKSPMFPALGEASSDDDLFQSAKPKPAKKTNPFPLLEDEDDLFTDQKVKKNETKSNSQQDVILTTQDIFEDDIFATEAIKPSQKTREKEKTLESNLFDDNIDIFADLTVKPKEKSKKKVEAKSIFDDDMDDIFSSGIQAKTTKPKSRSAQAAPEPRFEHKVSNIFDDPLNAFGGQ

Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L.

Q641Q2

Q5D7I5

TRIM5_CEBPY

TRIM5alpha

Cebuella

MASRILVNIKEEVTCPICLELLTEPLSLDCGHSFCQACITANHKESTLHQGERSCPLCRMSYPSENLRPNRHLANIVERLKEVMLSPEEGQKVDHCARHGEKLLLFCQQDGNVICWLCERSQEHRGHHTFLVEEVAEKYQGKLQVALEMMRQKQQDAEKLEADVREEQASWKIQIQNDKTNIMAEFKQLRDILDCEESKELQNLEKEEKNILKRLVQSESDMVLQTQSIRVLISDLERRLQGSVMELLQGVDDVIKRIEKVTLQKPKTFLNEKRRVFRAPDLKGMLQAFKELTEVQRYWAHVTLVPSHPSCTVISEDERQVRYQVPIHQPLVKVKYFYGVLGSLSITSGKHYWEVDVSNKRGWILGVCGSWKCNAKWNVLRPENYQPKNGYWVIGLRNTDNYSAFQDAVKYSDVQDGSRSVSSGPLIVPLFMTICPNRVGVFLDYEACTISFFNVTSNGFLIYKFSNCHFSYPVFPYFSPTTCELPMTLCSPSS

Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2.

Q5D7I5

A0A291PQG3

UGT4_DACCO

UDP-glucosyltransferase 4

Dactylopius

MTLLRDLLLLYINSLLFINPSIGENILVFLPTKTYSHFKPLEPLFQELAMRGHNVTVFSGFSLTKNISNYSSIVFSAEIEFVNIGMGNLRKQSRIYNWIYVHNELQNYFTQLISDNQLQELLSNKDTQFDLIFIELYHVDGVFALSHRFNCPIIGLSFQPVLPIYNWLIGNPTTFSYIPHVYLPFTDIMSFWKRIINAVFSIFTAAFYNFVSTKGYQKHVDLLLRQTESPKLNIEELSESLSLILAEFHFSSAYTRPNLPNVIDIAGIHIQSPKPLPQDLLDFLDQSEHGVIYVSLGTLIDPIHTDHLGLNLINVFRKLRQRVIWKWKKEFFHDVPKNVLIGEWFPQIDILNHPRCKLFISHGGYHSMLESIYSSVPILGIPFFTDQHHNTAIIEKLKIGKKASTEASEEDLLTAVKELLSNETFKRNSQHQSSIFRDRPMSPMDTAIYWTEYILRYKGASHMKSAVIDLYWFQYILLDIILFYSLIVLILLCILRIFFRMLTK

Catalyzes the transfer of a glycosyl group from a UDP-sugar to an acceptor molecule.

A0A291PQG3

Q03Y35

YBEY_LEUMM

Endoribonuclease YbeY

Leuconostoc

MDLAIIDQTKAGVNQYHQDLVRCVLDYAGKYLELPDNTEMSVTFMNNEEIHQYNKKYRGIDKPTDVISFAIEEDGDDLPVLPDELMDAELAKNIGDILVSVDIINSQAEYLGHSYERELGFLVVHGFLHLNGYDHMLGDAEEKEMFDLQREILDNYGLKR

Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

Q03Y35

A1K2P1

UBIA_AZOSB

4-HB polyprenyltransferase

Azoarcus

MTLSDRLPLYGRLMRLDKPIGSLLLLWPTLWALWLAADGKPPLHVLVIFTIGTVLMRSAGCVINDYADRDFDGHVERTRNRPLATRAVSTREALALAAGLSALSFVLILPLDPLVIWLSFPALFLAASYPFTKRFFAIPQAYLGIAFGFGIPMGFAAVQGEVPPIAWVMLLANIFWAVAYDTEYAMVDRPDDLKIGIKTSAITFGRFDVAAVMLCYAVALGLLGWVGAQAGRGALYFAGLAVAAGMALYHYTLIRHRERAPCFKAFRHNNWLGAAVFAGLALDYLIG

Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.

A1K2P1

Q9FH40

TA14B_ARATH

TBP-associated factor 14b

Arabidopsis

MTNSSSSKKQAQDQPETSEPTLKSLKTKMTKSDEKQKKLKDIEISVPIVYGNVAFWLGKKASEYQSHKWAVYVRGATNEDISVVVKKVVFQLHSSFNSPTRVIEEPPFEVSESGWGEFEIAMTLHFHSDVCDKPLSLYHHLKLYPEDESGPLTMKKPVVVESYDEIVFPDPSESFLARVQNHPALTFPRLPSGYNLPAPMQVEDTGKKKRGDTKDHSLGQWFMSFSEADELLQLAAARQQVQAHIAKLRRQISLLEGQNQTVKTGSDL

Negative regulator of flowering controlling the H4K5 acetylation levels in the FLC and FT chromatin. Positively regulates FLC expression. Component of the transcription factor IID (TFIID) complex that is essential for mediating regulation of RNA polymerase transcription. Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of a NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A.

Q9FH40

Q7T046

VM3CX_MACLB

Coagulation factor X-activating enzyme heavy chain alternate form

Macrovipera

MMQVLLVTISLAVFPYQGSSIILESGNVNDYEVVYPQKITALPEEAVQQPEQKYEDTMQYEFEVNGEPVVLHLEKNKDLFSEDYSETRYSPDGRETTTKPPVQDHCYYHGRIQNDAYSSASISACNGLKGHFKLQGETYLIEPLKIPDSEAHAVYKYENIEKEDEAPKMCGVTQTNWESDEPIKKASQLVATSAKRKFHKTFIELVIVVDHRVVKKYDSAATNTKIYEIVNTVNEIFIPLNIRLTLIGVEFWCNRDLINVTSSADDTLDSFGEWRGSDLLNRKRHDNAQLFTDMKFDLSTLGITFLDGMCQAYRSVGIVQEHGNKNFKTAVIMAHELGHNLGMYHDRKNCICNDSSCIMSAVLSSQPSKLFSNCSNHDYRRYLTTYKPKCILNPPLRKDIASPPICGNEIWEEGEECDCGSPKDCQNPCCDAATCKLTPGAECGNGLCCEKCKIKTAGTVCRRARDECDVPEHCTGQSAECPADGFHANGQPCQNNNGYCYNGDCPIMTKQCISLFGSRATVAEDSCFQENQKGSYYGYCRKENGRKIPCAPQDIKCGRLYCLDNSPGNKNPCKMHYRCRDQHKGMVEPGTKCEDGKVCNNKRQCVDVNTAY

Catalytic subunit of blood coagulation factor X-activating enzyme. Activates coagulation factor X (F10) by cleaving the Arg(234)-Ile(235) bond, activates coagulation factor IX (F9) by cleaving the Arg(226)-Val(227) bond and is also able to activate protein C (PROC).

Q7T046

P13388

XMRK_XIPMA

Melanoma receptor tyrosine-protein kinase

Xiphophorus

MEFLRGGAALLQLLLVLSISRCCSTDPDRKVCQGTSNQMTMLDNHYLKMKKMYSGCNVVLENLEITYTQENQDLSFLQSIQEVGGYVLIAMNEVSTIPLVNLRLIRGQNLYEGNFTLLVMSNYQKNPSSPDVYQVGLKQLQLSNLTEILSGGVKVSHNPLLCNVETINWWDIVDKTSNPTMNLIPHAFERQCQKCDHGCVNGSCWAPGPGHCQKFTKLLCAEQCNRRCRGPKPIDCCNEHCAGGCTGPRATDCLACRDFNDDGTCKDTCPPPKIYDIVSHQVVDNPNIKYTFGAACVKECPSNYVVTEGACVRSCSAGMLEVDENGKRSCKPCDGVCPKVCDGIGIGSLSNTIAVNSTNIRSFSNCTKINGDIILNRNSFEGDPHYKIGTMDPEHLWNLTTVKEITGYLVIMWWPENMTSLSVFQNLEIIRGRTTFSRGFSFVVVQVRHLQWLGLRSLKEVSAGNVILKNTLQLRYANTINWRRLFRSEDQSIEYDARTENQTCNNECSEDGCWGPGPTMCVSCLHVDRGGRCVASCNLLQGEPREAQVDGRCVQCHQECLVQTDSLTCYGPGPANCSKSAHFQDGPQCIPRCPHGILGDGDTLIWKYADKMGQCQPCHQNCTQGCSGPGLSGCRGDIVSHSSLAVGLVSGLLITVIVALLIVVLLRRRRIKRKRTIRCLLQEKELVEPLTPSGQAPNQAFLRILKETEFKKDRVLGSGAFGTVYKGLWNPDGENIRIPVAIKVLREATSPKVNQEVLDEAYVMASVDHPHVCRLLGICLTSAVQLVTQLMPYGCLLDYVRQHQERICGQWLLNWCVQIAKGMNYLEERHLVHRDLAARNVLLKNPNHVKITDFGLSKLLTADEKEYQADGGKVPIKWMALESILQWTYTHQSDVWSYGVTVWELMTFGSKPYDGIPAKEIASVLENGERLPQPPICTIEVYMIILKCWMIDPSSRPRFRELVGEFSQMARDPSRYLVIQGNLPSLSDRRLFSRLLSSDDDVVDADEYLLPYKRINRQGSEPCIPPTGHPVRENSITLRNISDPTQNALEKDLDGHEYVNQPGSETSSRLSDIYNPNYEDLTDGWGPVSLSSQEAETNFSRPEYLNTNQNSLPLVSSGSMDDPDYQAGYQAAFLPQTGALTGNGMFLPAAENLEYLGQGGALYTPVR

Probable receptor with tyrosine-protein kinase activity.

P13388

Q63HD6

TILS_BACCZ

tRNA(Ile)-lysidine synthetase

Bacillus cereus group

MKDTFVEKVDDFVKQHDVLKEHSTIVVGVSGGPDSLALLYYLLEKRAAKQFEIVVAHVDHMFRGDESHEDLQFVQDLCKGLGVICETIRINVSQYQQQYGMNAQVAARECRYAFLERIMKKYDARYVALGHHGDDQVETILMRLVRGSTPKGYAGIAVKRPFHNGYLIRPLLGVTKEEIVDYCNKLKIIPRIDPSNKKEVYTRNRLRKYVLPHLKEENPQVHEKFQKFSMQMQEDEAYLQELAFEKMNKVITKKSDKQISLSIPAFESMSMPLQRRGIQLILNYLYEYKIPSSLSSIHIDKVIEFFKRTQPSGSLDFPGDLKIVRAYEECSFGFKQEIVSPFLQDLSVPGTITLSNGDKLVTEVSEDIPSDMNETVFVAKYNDISYPLRIRSRENGDRMSIQGMNGTKKIKAIFIEAKVPREKREEWPVVCDASGNVIWLPLLKRSAFAISKETAKKDKYMIIHYKSKESSGRIMK

Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.

Q63HD6

Q52377

UVRC_PSEU2

Excinuclease ABC subunit C

Pseudomonas syringae

MTQTFDPGAFLATCSGRPGVYRMFDAEATLLYVGKAKNLKKRLASYFRKTGHAPKTGALVSRIAQIETTITGNETEALLLEQTLIKEWRPPYNILLRDDKSYPYVFLSDNAFPRLSIHRGTKKAKGRYFGPYPSAGAIRESLSLLQKTFQVRQCEDSYFKNRTRPCLQYQIKRCKGPCVGLVEPEVYAEDVRHSVMFLEGRSNALSDELNASMEKAAMALDFERAAELRDQVALLRRVQDQQSMDGGTGDVDVVAAFVNPGGACVHLISVRGGRVLGSKNFFPQVGIEEEVGEVMSAFLAQYFLGGIDRELPGEVIVNVINDDFPAFVDAVEELRGVEMVISHRVRGTRARWQQMAVTNAEQALTARLANRQHVASRFEALAKVLGLEDPPMRLECYDISHSSGEATVASCVVFGPEGPIKSDYRRFNIEGVTAGDDYAAMHQALTRRYSRIKAGEGKLPDVLLVDGGKGQMSMARDVLNELQVPELILLGVAKGTTRKAGFETLYLNDSAHEFTLPGDSPALHLIQQIRDEAHRFAITGHRARRGKTRRTSTLEGVAGVGPTRRRDLLKHFGGLQELSRASIDEIAKAPGISKKLAESIYANLHSE

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

Q52377

Q4N938

TCTP_THEPA

Translationally-controlled tumor protein homolog

Theileria

MKVYKDLYSNDEVCSDAYDHHDPFDNADLSSVAFEVKTSKVPKGEEDYGIGYNDEEGADQMNVDPNVEMVVDVVDKFGLQSLSLTKKDYSSYIRKYIQRLVATLQEKNPERVEPFKTTVSDFVKHVLANFEDFEFYVGESLDYEAGLVYAYYKGEEVSPRLVFLKDGLVEERY

Involved in calcium binding and microtubule stabilization.

Q4N938

Q17WX3

TRUD_HELAH

tRNA-uridine isomerase D

Helicobacter

MNLNFMPLLHAYNHASIDFHFNSSARDFCVHEVPLYEFSNKGEHAIIQVRKSGLSTLEMLQIFSQILGVKIAELGYAGLKDKNALTTQFVSLPKKYAPLLEKNTSNFQERNLKILSLNYHHNKIKLGHLKGNRFFMRFKKMTPLNAHKTKQVLEQIVQFGMPNYFGSQRFGKFNDNHKEGLKILQNEAKFKNQKLNAFLISSYQSYLFNSLLSKRLEISKIISDFSLKEGLEFFKQKNLNIHSNALKALKNQDHPFKILEGDVMCHYPYGKFFDALELEKESERFLKKEAVPMGLLDGKKALYAKNLSLEIEKEFQNHILSDHAKTLGSRRFFWVFVENLTSKYIKEKVQFELEFYLPKGSYASALLKEIKHQKGENNDEF

Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

Q17WX3

O00300

TR11B_HUMAN

Osteoprotegerin

Homo

MNNLLCCALVFLDISIKWTTQETFPPKYLHYDEETSHQLLCDKCPPGTYLKQHCTAKWKTVCAPCPDHYYTDSWHTSDECLYCSPVCKELQYVKQECNRTHNRVCECKEGRYLEIEFCLKHRSCPPGFGVVQAGTPERNTVCKRCPDGFFSNETSSKAPCRKHTNCSVFGLLLTQKGNATHDNICSGNSESTQKCGIDVTLCEEAFFRFAVPTKFTPNWLSVLVDNLPGTKVNAESVERIKRQHSSQEQTFQLLKLWKHQNKDQDIVKKIIQDIDLCENSVQRHIGHANLTFEQLRSLMESLPGKKVGAEDIEKTIKACKPSDQILKLLSLWRIKNGDQDTLKGLMHALKHSKTYHFPKTVTQSLKKTIRFLHSFTMYKLYQKLFLEMIGNQVQSVKISCL

Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.

O00300

Q25113

TBXT_HEMPU

Protein T

Hemicentrotus

MPAMSADALRAPSYNVSHLLNAVQSEMNRGSEKGDPSEEGLKVRLDDVELWKKFHKLTNEMIVTKSGRRMFPVLSASIAGLDPNSMYSVLLDFSAADDHRWKYVNGEWIPGGKPDGSPPTTAYIHPDSPNFGAHWMKQAVNFSKVKLSNKLNGSGQVMLNSLHKYEPRIHIIRVGGREKQRLVGSYSFTETRFIAVTAYQNEDITQLKIKYNPFAKAFLDIKDKNDGHDLFDDVHDFQGSKYPQFGGWFLPGSGAFGPTPHQFNPSIGLPSHAGCDRYGGLRSHRTSPYPPPPYHQKYSAAGAGYGAEASAGLSSSISLLAADSWSSLANSTSAASSMPACSQYGSMWPSTAATSGFSHVSSPQSPLPTGLFRNPHPTSSHQHNLASTAHGMAPVASGLPSAAVTTANSSEAHALSQSVMAPGECRASDNAGYL

Involved in the transcriptional regulation of genes required for mesoderm differentiation.

Q25113

Q5BBK9

VPS27_EMENI

Vacuolar protein sorting-associated protein 27

Aspergillus subgen. Nidulantes

MAGWFSSASPLDEQIERATASSLEDIALNLEISDLIRSKGVQPKDAMRSLKRRLENKNPNIQIATLKLTDTCVKNGGTHFLAEIASREFMDNLVSLLKAEGVPLNSSVRDLMLALIQDWAMAAQGRMDLSYLGETYRKLQMEGFQFPPKSAISGSMLESSAPPEWIDSDVCMRCRTPFSFMNRKHHCRNCGNVFDAQCSSKTLPLPHLGILQPVRVDDGCYAKLTSKPFNQGSLADRSTFKNNSITKSNVLEPRAARVESGFDEDLRRALQMSLEEAQNKSSSGYVPQPKPAQAPANTQPQPSTDEEEDADLKAAIEASLRDMEEHKQKYAAALKNNTSAESSRETPAAASLPKNPYELSPVEVENIHLFSTLVDRLQHQPPGTILREPQIQELYESIGALRPKLARSYGETMSKHDTLLDLHAKLSTVVRYYDRMLEERLSSAYSQHNLGYGPVPGGAQYPNIYPSMPSTTAEVRPGAENFYYGNSGVEPPAPARTPYSQPPLERENGVVSSSMHPPLQQPSSGPYWNPNNHSIASPQPNVNAFNSNNTPYPGPGAPSQFYTSSAYQEPEKLFQQPRQGEPESPYQPSPVTNRDSYYQSAGLPSNPVEQQPPVDHGQSPGHAQPADSRSSQSGQPKATEPSAQSYYLPQEQQQQQQQQQQQSAQGTGYQGYPQGNTNYQAPYGGDVSPISAPPPVQYQQPAAPRPVVEESLIEL

Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.

Q5BBK9

B0RYY8

TTCA_XANCB

tRNA 2-thiocytidine biosynthesis protein TtcA

Xanthomonas

MTAVLPLPLPLADPAPRTPRLQREPLRLAKRLRHAVGQAIADFGMIAPGDKVMVCLSGGKDSYTLLDMLLQLQRSAPVPFTLVAVNLDQKQPDFPADVLPTYLRAQQVPFDIIEQDTYSVVSRVIPQGKTMCSLCSRLRRGALYAYAQAHGVTKIALGHHRDDIVATFFMNLFHHARLAAMAPKLRSDDGAHVVIRPLAYVREADIAAYAQARHFPIIPCNLCGSQENLQRQQVGRMLQQWDREQPGRVDQIARALGDVRPEQLADRTLFDFPGLGGGADAPLPDAAGWLAGSAAEHARD

Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.

B0RYY8

Q7NFD4

UVRC_GLOVI

Excinuclease ABC subunit C

Gloeobacter

MPNLIADPERLKERLELLPTSAGVYLMRDEAGEILYVGKAKNLRNRVRSYFQPGHDHSPRIAIMVGKVHDFELILTDTEAEALVLEDNLIKTHKPRYNVLLKDDKQYPYLCITWSEEYPRIFVTRRRGSGHPEDRYFGPYTDAGALHSTLGLLKKLFPLRQRNTPVFKDRPCINYEMGRCPGLCQRLISPQEYRATIRQIQMILQGRTAELLAQLEDQMQTAAAAMNFEHAARLRDRITGLNQLGAHQKITVPDSSVSRDAVALAADAALVSIQLFQVRSGKLIGRLGFSAAASGEDPGHILQRVLEEHYRASASEEIPLEVLTQHPLPEADILATWLAEKKGRKVEIHAPQRQIKAELVEMVARNAEAELQRLERFSRRQEKGLLNLAEALELPSVPRRMECYDISHIQGTDTVASRVVFVDGAPAKQYYRHYKIRDPRIVAGRPDDFASMAEVISRRFARAESEPEGDLPDLVVIDGGKGQLSAARAVMEELSYGDVPTIGLAKRLEEVFLPGRSDPVLIAQGDPALHLLQRIRDEAHRFAVSFHREQRGKRMTRSSLDDIPGIGPAKRKILLDTFRSVPVLEKASFEEIAKTPGIGSRLAQVIHTYFHGEPEAVARALEAEQAAN

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

Q7NFD4

B6JCL3

UPPP_AFIC5

Undecaprenyl pyrophosphate phosphatase

Afipia

MLFDLFKALVLGIVEGVTEFLPVSSTGHILLAERIFDLDQDNFWKTFAVLIQLGAILAILAIYFQRLWRVATHMFTDPAARRFVIGVLVAFLPAVILGLIFGTFIKEVLFNPWVVCFSLIAGGAVLLWVDQQDVNPRHHDAMAFPLPMYLGIGIAQCAAMVPGVSRSGASIVAAMLFGADKRAAAEFSFFLAIPTMLGAFVYDVYKSRGDMTMDHAFIIIVGFVVSFITAIVVVKTFLDFVTKNGFTFFAWWRVIVGTLGLIALALGA

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.

B6JCL3

Q87BK9

UVRA_XYLFT

Excinuclease ABC subunit A

Xylella

MTALIRIRGARTHNLKNLDLDLPRNTLIVITGLSGSGKSSLAFDTIYAEGQRRYVESLSAYARQFLSVMEKPDVDHIEGLSPAISIEQKSTSHNPRSTVGTITEIYDYLRLLYARVGQPRCPEHHYPLEAQTVSQMVDHVLTLDPEQRYMLLAPVVRERKGEHTQVFEQLRAQGFVRVRVDGELYEIDAVPTLTLRQKHTIEAVIDRFRPREDIKQRLAESFETALKLGNGMASVQTLDTTTATPHLFSSKYSCPVCDYSLPELEPRLFSFNAPMGACPACNGLGVTEFFDPAKVVIHPDLSLSAGAVRGWDRRNAYYFQLIASLAKHYTFDIDASWESLPEEIRHTILFGSGDEQINFTYLTEAGGRTKRKHRFEGIVPNLERRYRETESAAVREELAKYVSTRTCPECGGTRLNRAARNVFVADRTLPELTVLPINDALEFFKTLRLSGWRGEIAIKIVKEIGERLGFLVDVGLDYLTLERKADTLSGGEAQRIRLASQIGAGLVGVMYVLDEPSIGLHQRDNERLLGTLTRLRDLGNTVIVVEHDEDAIRQADHILDIGPGAGVHGGEICAQGSLEQIMAAPRSLTGQYLSGRRRIEIPKQRHPPNATKMLHLRGACGNNLKGVNLDIPEGLFTCITGVSGSGKSTLINDTLFTLAANEINGASHPIAPYASVDGLELFDKVVDIDQSPIGRTPRSNPATYTGMFTPLRELFAQVPEARARGYSPGRFSFNVRGGRCEACEGDGLIKVEMHFLPDVYVPCDICHGKRYNRETLEIRYKGYNINDVLEMTVEDALKLFEAVPAIARKLETLVDVGLSYLKLGQSATTLSGGEAQRVKLSKELSRRDTGHTLYILDEPTTGLHFYDIEALLAVMHKLRDAGNTVIVIEHNLDVIKTADWVIDLGPEGGGRGGEILVAGTPETVAAHPHSHTGHFLAKLLPPKDVSNCGHRNPKEEVDIAKTVHR

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

Q87BK9

Q6SJR1

TAF4_ARATH

TBP-associated factor 4

Arabidopsis

MDLSIVKLLEEDEEVDSKHSEDDLQMFQDSLIRDIEGSNLKSINNTTGNESEKPQPRYMKLQKMSSKETPWVEKTVDPVNHNLRLARVTDLLRTVVDHQPGKKTHCLNLHYKLKRKELTMEEFMRQLRDLVGDQIIRSVISQLPQLKPGNMGIKVPGRSNHDKVSKSAEFTAQESDPREVHVNQLSSTTSGTLNSSTTVQGLNKHPEQHMQLPSSSFHMDTKSGSLNPYPGTNVTSPGSSSRAKLPDFQHRENNQNVGIASVGGPTKSTINMTTVPKFERPTFVNGPSRVQDGPISDFPKNSSFPLYSAPWQGSVTKDHTVGPSSSVIHVEHKLIDQSFEQAHKPRYLVQQGVTNVPLKQKNAIPISSNDDLEKQSSKMGLFTSTTSASSVFPSMTTQLDSSTMVNMPAPSETIPKIANVTVTPKMPSVGQKKPLEALGSSLPPSRKKQKICGTSSDESIEKFNDVTAVSGINLREEEKQLLDSGPKKNDRVSKAYRRLVHGEEERTLLQKIPLQRKLTEIMGKSGLKHIDHDVERCLSLCVEERMRGLLFNIIRISKQRTDAEKCRNRTFITSDIRKEINEMNQKVKEEWEKKHSGEEKNKENDTEKEDQRSNEVKANKKDEDKERAKAANVAVRAAVGGDDRFSKWKLMAEARQRSSPGPGRNSKKLSGGTQFGKNQGLPKVVRSISVKDVIAVVEKEPQMSRSTLLYRVYNRICSDV

TAFs are components of the transcription factor IID (TFIID) complex that is essential for mediating regulation of RNA polymerase transcription.

Q6SJR1

O26024

Y1491_HELPY

Putative phosphate permease HP_1491

Helicobacter

MEIKNIKEFEKASKKLQKDTLKIALALLFLIGAALLALIFGQANSKGLLLIFAAVIGGYMAMNIGANDVSNNVGPAVGSKAISMGGAILIAAICEMLGAIIAGGEVVSTIKGRIVSPEFINDAHIFINVMLASLLSGALWLHVATLIGAPVSTSHSVVGGIMGAGMAAAGMVAVNWHFLSGIVASWVISPLMGALIAMFFLMLIKKTIAYKEDKKSAALKVVPYLVALMSLTFSWYLIVKVLKRLYALNFEIQLACGCILALLIFILFKRFVLKKAPQLENSHESINELFNVPLIFAAALLSFAHGANDVANAIGPLAAISQTLEDANSPIGNTLSSVPLWIMVVGAAGIALGLSLYGPKLIKTVGSEITELDKMQAFCIALSAVITVLLASQLGLPVSSTHIVVGAVFGVGFLRERLREQSRRRFARIRDNIVAAHFGEDLEEIEGFLERFDKANLKEKSLMLESLKKSKNTAIALELKKKEKKSLKKVYKEEVIKRSILKKIVTAWLVTVPVSALLGALLFVALGFIEKYF

Potential transporter for phosphate.

O26024

P31058

YADC_ECOLI

Uncharacterized fimbrial-like protein YadC

Escherichia

MKTIFRYILFLALYSCCNTVSAYTSFIVGNNAGVDNYRGPSTAAQMTFNYTSTASNLVFYKPTQLGPTGVKMYWSYLDTGTGGGILYCNTSGRANPGPITIENAMVYSGKDYGGHKLFNTSVPGLYYTMLISRVWSAYDTITDIQSPGIYIGDPSNQEFFFSVTDSDLQTKGCNKADDYDKFWAIGGIVHNITVEFYTDTNFDPTLNQQVQLSSSSNYLYSFKAYSPGTKVVDHSNHIYVNFTLNNVKLTLPTCFTSILTGPSVNGSTVRMGEYSSGTIKNGASPVPFDISLQNCIRVRNIETKLVTGKVGTQNTQLLGNTLTGSTAAKGVGVLIEGLATSKNPLMTLKPNDTNSVYIDYETEDDTSDGVYPNQGNGTSQPLHFQATLKQDGNIAIEPGEFKATSTFQVTYP

Part of the yadCKLM-htrE-yadVN fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches.

P31058

A7A047

TVP38_YEAS7

TLG2-vesicle protein of 38 kDa

Saccharomyces

MSQSYEAGNANMGQGEDDEFDGYFEDFDNDIMPNSNNGQRVGTNAGLSFNDEVNVNDDDFLDIYNMSPRERLMHNIRKNVQKLQFYFYSLRLWQQIIIVLLGIMLMIMGILLLVFHNAILHKVVVTSNDLREKMSTHFILMVLIFFVAFPPMIGYSLLSTTTGLIYGVSFEGWVTLALGSVTGSIASFVVFKTILHSRAEKLVHLNRRFEALASILQENNSYWILALLRLCPFPYSLTNGAIAGVYGISVRNFSIANIITTPKLFIYLFIGSRVKSLAESESTGSRVFDLVSIIITLLILSLTAWLLYFKTKKRYLELQNRDRQVSTDQLPELSFEV

Golgi membrane protein involved in vesicular trafficking and spindle migration.

A7A047

O58762

TRET_PYRHO

Trehalose-synthesizing glycosyltransferase

Pyrococcus

MMYEVKEFSSGKRKLEDYKSIIGEEEVSKIQEKAEKLKGRSFVHVNSTSFGGGVAEILHSLVPLLRSIGIEARWFVIEGPTEFFNVTKTFHNALQGNESLKLTEEMKELYLNVNRENSKFIDLSSFDYVLVHDPQPAALIEFYEKKSPWLWRCHIDLSSPNREFWEFLRRFVEKYDRYIFHLPEYVQPELDRNKAVIMPPSIDPLSEKNVELKQTEILRILERFDVDPEKPIITQVSRFDPWKGIFDVIEIYRKVKEKIPGVQLLLVGVMAHDDPEGWIYFEKTLRKIGEDYDVKVLTNLIGVHAREVNAFQRASDVILQMSIREGFGLTVTEAMWKGKPVIGRAVGGIKFQIVDGETGFLVRDANEAVEKVLYLLKHPEVSKEMGAKAKERVRKNFIITKHMERYLDILNSLGG

Synthesizes trehalose from ADP-, UDP- or GDP-glucose and glucose.

O58762

Q9JJD0

THA11_MOUSE

Ronin

Mus

MPGFTCCVPGCYNNSHRDKALHFYTFPKDAELRRLWLKNVSRAGVSGCFSTFQPTTGHRLCSVHFQGGRKTYTVRVPTIFPLRGVNERKVARRPAGAAAARRRQQQQQQQQQQQQQQQLQQQQPSPSSSTAQTTQLQPNLVSASAAVLLTLQAAVDSNQAPGSVVPVSTTPSGDDVKPIDLTVQVEFAAAEGAAAAAAASELEAATAGLEAAECTLGPQLVVVGEEGFPDTGSDHSYSLSSGTTEEELLRKLNEQRDILALMEVKMKEMKGSIRHLRLTEAKLREELREKDRLLAMAVIRKKHGM

Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers.

Q9JJD0

P70901

VLP12_BORHE

Variable large protein 12

Borrelia

MRKRISAIIMTLFMVLASCSNQLEAEKLAAESKNTFFDSLVKIGQGFQDIFGIFGNAIGDALGFNAVKSDDKRSKVGEHFEGVGKGLKDTKIKLDELLKEVTAAPHADTTEVKSVINSASAVLTKLIDSVTKLAGAVGNTDIADGVSIANGAAAEEASVKTVIEGVKEIIDVATNSGVKIEKGNAGTAVANANGPKAIIHNAQAAAGDATKLADEVAKADPWAMIDKIKNAKTKNGIAAANDDAGQLATATNAANNNGTAATNADLAAAVALKAMAKGGKFTQPAANEDGAVKAAAASAVNKVLGILDVIIRKAVNLELGKIKEAVKGIKYSEATGEATESDTAQPITNKSSN

The Vlp and Vsp proteins are antigenically distinct proteins, only one vlp or vsp gene is transcriptionally active at any one time. Switching between these genes is a mechanism of host immune response evasion.

P70901

Q291E4

VIR_DROPS

Protein virilizer

Sophophora

MTEVDDGAELLFFDTFSHEDITDINLDLVQFPKPVFITQVRIIPLGARVQADFPGGVRLGATNPSKFDLEFFVNDLGMPGASAFENLGLLRYNQNDCIHLDCSREKIPTDGLVLRGWYSTITLAVYGILTNSVTQPIASPTLPCEPAGPEMCNLSTEAHNVLLQEEVLKDDWAEPIPTELLVPHKAVVVSDYEHDDIEYGLSREHQHYHQHVDEEQREMRRLRRSTHSTDRSPPPPPMRTHTHSESNEREYIRCSRDKGSRDWSRSPEYSSHRSRRKRSDRSRSDADEHKWPRTPPASIDSPIRPRSPDAMDYDDDDSRSHYKMQASRGYRHSSESLHRDRDDEERSGTPQEQFEPILSDDEIIGDDEEDEAEDVAAAAEYERELEFAAAVAPPAIDAFEPWQRPLLVYEGDLAAHLNKELETLRLLFKKLSLQTRCESVTAFSDEHGLSADEREQFVYLGEQLNNQLGYLSQHYKRRNFVLQQFFSHDDAHLRQAANVLQVALSFQAACMQPQPAFKIRHIKLGARMAELLGSNEQLFGHLLQEQDFDLFEAVLSLYKEPYMALSIKLQLLKAVYAMLDTRLGVQNFLSPKTNGYQMVMDFLKTAKLTRTKYALQAIIKKLHLYEALASVQQCCRQIFLDTDASVPETTPDPNRLDVCQKIEFAFQMLMDALTDSQLSYQQPRRFLPVSKKFEVLTDPTAQRSFGNALQSYFVQHSLAEALLVILSNPKEVPASTFLCTLDLMHTLLRSHVGIDYFVDDAFPVTQMIVSILLGLEEVPSQPRVVEAKPEGKEDKPMDDSVEQKPDEGKAAGIRAAEEPKMAPPPVVRKPILRPVLPRLARLGIELSYKVQTRYHLDAITFTAACPEYDTIKIATHMHSIYSQTCDPSGRQHTIEVLGLNNNLKIFMDLIKKEQRLQTQRQLLSSPGTKYKSPVLSYAVDMVDACVRYCEQLDYLIEHGGVILELAKNHETFEPSVSAVLQEMYVYMKPLEAINVFVYDDIMPLVEVIGRSLDYLTTFPGDLIMALRILRFLAISKPRQKSHGTEELKHRFVALQLYAADGVQLLLQIMERLCTHFEQPGIHAPALMTIQGVHCCQIMLPTLQILRELLSYAILCRDGTYKDLTAIDHLVKVYYLLYYYPSRCQAGAEVEQCKLEVVKSLLAYTQPHEQDAESLHKSLWTLMVREVLKNIDGPAHFIPGLKLLAELLPLPLPMPQPLCDQLKQQHKQRLIIERKLWSAHLHPQSGQIAKLVEALAPSSFPQLAELLQRVCMQLSDLAPNMTLLIAKTITELLCTEYQTSNCIPTTNLERLLRFSTRLCAFAPLKSSMLSILSGKFWELFQSLLALNEFNEVVTNCQEAVHRILDSFLDSGISLISHKSTAQPALNLSAALPPKELIPRIIDAVFSNLTSVEVTHGISILAVRNLVILTEHDFTFYHLAQLLKQKLTEFQAWMERVILHNETVEYHANIESLILLLRSLTQIEPPPPMCAMPNRTLKLGAMELAQLVEFQDIDMARPPVLARILRVLEKYKLLANEAALCDLKQLIVLHASRQEAMGSASMETPAVETENDGANPAASCSTSSSGGSLNVEPFLPQAEGIVTQYDARPIFTRYCATAENPQLTARYWLEPLPIELIEDMNEPLYERIACDLTDLANVCLNPDLATSGESKRTLNLSGSPQSNREMTPTAPCFRTRRVEVEPATGRPEKKMFLSSVRGRGFARPPPSRGDLFRSRPPNTSRPPSLHVDDFLALETCGAQPTGPTGYNKIPSMLRGSRVGRNRGSRISAAAAFRQKKMMRIGSPSSWTESGGGSYRSTSESHFGGSDSHYSSPHYSGRSRGRGLRSRPPYLR

Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of mRNAs, a modification that plays a role in the efficiency of mRNA splicing and is required for sex determination. Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines female physiognomy. M6A methylation is also required for neuronal functions. Required for proper inclusion of regulated exons in Ubx transcripts, leading to isoforms Ia/b and IIa/b.

Q291E4

Q29VN1

TPS3_MAIZE

Probable terpene synthase 3, chloroplastic

Zea

MYSLPGATMSAAPARVISSSSSSSFVEPLLLAAASSAAANSHHQVRQRGHLVRTLAASSSSNTLLRSDFDLQEGLTTDVKRMLRQRQKKSGGGREMLVTIDNLKRLCIDHFFEEEIEGAMATGACTRLLHSDDLFDATLAFRLLREAGHDVSAKEDVLRRFIDGVSGDFKLSLNNDVRGLLGLHDMSHLDVGGEEAALLHRAKEFSSSHLASAVRYQDNPSLAEYVRQSLDHPYHLSLTQYKARHHLRYLQSLPSSCRDAAVERLAVAEFQLNKSLHQREMREIKRWWMDLGLAEEIPVVRDQVMKWYMWSMAALQGSSFSRYRVYVVDDIFDLVGTLEELSAFTEAVKMWDTAAADSLPSCMRSCYKALHTVTNEIAEIAHKEHGSNPINRLRKAWVVLFDGFMVEARWLATDQVPTAEDYLRNGVVTSGVPLTFLHIFSMLGYDDPSTEEEEEAIIDHMPSIISCPAKILRLWDDMGSAEDEAQEGFDGSYRDFYLMENPSRSPGEAEAHMRGLIAREWVELNRECFCRRTFPSDIAQVCLNTARMVSVMYSYNKEQRLLVLEDYAAMMLVL

Probable terpene synthase.

Q29VN1

Q757R0

VAC8_ASHGO

Vacuolar protein 8

Eremothecium

MGGCCSCLKESQDDATVLPIAENEREAVTSLLGYLEDKDNYDFYSGGPLKALTTLVYSDNLNLQRSAALAFAEITEKYVRPVDREVLEPILILLQSHDPQIQIAACAALGNLAVNNENKILIVEMGGLEPLIEQMKSNNVEVQCNAVGCITNLATQDDNKAKIAHSGALVPLTKLAKSKNIRVQRNATGALLNMTHSGENRKELVDAGAVPVLVSLLSSSDADVQYYCTTALSNIAVDESNRRKLSQTEPRLVSKLVVLTDSPSARVKCQATLALRNLASDTGYQLEIVRAGGLSHLVKLIQCNSMPLVLASVACIRNISIHPLNEGLIVDAGFLKPLVKLLDYNDNEEIQCHAVSTLRNLAASSEKNRQEFFESGAVEKCKQLALVSPISVQSEISACFAILALADNSKLELLDANILEALIPMTFSTNQEVAGNAAAALANLCSRINNYEKIIESWTEPSKGVCGFLIRFLQSEYPTFEHIALWTILQLLESHNETMLGLIKSNKEIVKSIKRLSDINYENAQKASSLHSRLQQVNGGSVASGSEQYEHASLELYNITQQIMQFLN

Functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole.

Q757R0

Q6BQJ1

TVP38_DEBHA

Golgi apparatus membrane protein TVP38

Debaryomyces

MPRLPSSSDPFQGHNELPQSNNFMSRTNSIIQDKLFLVRNVGQQTLDWYQSQPLWKRTLLQVLFVFNAIVVVLIMIFHKSIIQAIVVISDKWHGLKFGQGLLFTLVFMVGFPPLLGFSALSMLAGMVYGFVHGWILLACASISGSFCSFLVFRYLLHSRAERLMNSNKKFRAFSEILREDSSLFILVLLRLCPLPYSLSNGALAAIPELPATTYFLASLITSPKLMIHIFVGHKLKELGDDTKGKSTHLIDILSIIITGAAASLTTYIIYNKMQRKLEFYHQRGIIPRDDAIIFGNFEDIESANNVELNSADYDEDNFIIEDEDDENATDPDYVASKKNIQVHAEDQNKNGEFEIDENDGVDDLGLGEISKNSKQNTNGYRDY

Golgi membrane protein involved in vesicular trafficking and spindle migration.

Q6BQJ1

A1WUY5

UPPP_HALHL

Undecaprenyl pyrophosphate phosphatase

Halorhodospira

MALWIAVLLGVVQGIFMFLPVSSTAHMVLLEHWLIGRDHPMPAPESAEMILFNLVVHVGTLVSIVVVFAPSLLRFTRYSLRDAYGWARAGRFQGPPLYARLFLLGMLSVLFTGVVGLTLKATFEQVFANPWMIAFTLILTGALLFWTDKLPPRRRGLRQTGVGTATLIGVAQGFALMPGLSRSAMTIVFGLFAGLKRRWAAEYSFFLAIPTICAATLLQAIEVYQLGGLESVSVAALITGFVVAAGVGIVSLKLVIYFLYRAQLKVFSFYVWALAAAILLGWIDLPI

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.

A1WUY5

Q6ANL3

UBIE_DESPS

Demethylmenaquinone methyltransferase

Desulfotalea

MRAQSCSLFLEMKCREEFVLSKGPGVEKMFDAIAGRYDLMNKVMTMGQDQRWRRFVVAKAGDPGAGQVLDLATGTGDIAALMHRSYPRAQVTGGDFSRNMLEEAKKRFAGQGIDWQVCDANKLPFADNTFEAVTFGYLLRNVDDASSVLAEVYRVLKPGGRCVCLDTTPPAKNIIYPFVQFYFRYGIPLLGRMIAADEAAYAYLSGSTMEFHSAEVLADLFRGAGFVDVHYKKFMLGTIGIHWGVK

Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).

Q6ANL3

P25040

TSR4_YEAST

20S rRNA accumulation protein 4

Saccharomyces

MSKIEELPPSDTDDHSYSSKPGDVFLAFVDAPVKETDDILVEDSFIGGEPKWLHPDSEPPAELLKCGACKSADNMKLLLQAFSPLDDEQMSAIQQRLGINNMSYINPQDDRVLYVFLCTECQRKGNSVRCIRGVKKNKNVDSLSEKMASTSLEKDFQINPFDLSNNSDSKCNAFSSNPFGGANANPFGADSINSNISQSKDEGKKKESATVSAKTARKLHDLQKDKEYDGNKCFKSCLLYVEEETFKNKKPAHLQLPKNLKIDKEALDLTGDEDLEKDPIKLDPRTEKLSKFLDDDTFQKFQEVVGYNPLQVLRYDLGGKPLLYAETKVDILSTVPRPGYNPSSQRIFEMQLMPKMIFDLEEVVSVDNGMEWGTILVFTDVENYMPEFDEHGVGYVEECVKVQWESRT

Required for processing of the 20S pre-rRNA at site D to generate mature 18S rRNA.

P25040

Q1BV59

TYPH_BURCA

TdRPase

Burkholderia cepacia complex

MFLPQEFIRRKRDGQPLDRDDMAAFVRGVTDGSVTEGQVAAFAMAVYFNDLSTDERVALTLAQRDSGDVLDWRALDLGGPVIDKHSTGGVGDVVSLMLGPMVAACGGYVPMISGRGLGHTGGTLDKLSAIPGYDVMPDTDAFRRTVREVGVAIIGQTARLAPADKRIYAIRDVTATVESVAMITASILSKKLAAGLDGLVMDVKVGSGAFMPTAEKSAELARSIVDVGNGAGMKTTAILTDMNQSLAPCAGNALEVACAIDYLTGKSRPARLHDVTMALSAELLVTGGLARDAAHAREKLQQALDSGAAAERFARMVAALGGPADLLDAPARHLARAAVIVPVPAPVSGVVQRVDCRALGLAVVALGGGRTRAEDAIDVSVGLSALAEIGQRIEAGEPLGFVHARDEAAAAHAVDAIRRGYVLGETGEAPPTLYQRVD

The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.

Q1BV59

A0R2W4

ZFPP_MYCS2

Z-isoprenyl diphosphate synthase

Mycolicibacterium

MDIIPPRLKEPAYRIYEMRLRHELVRSKAQLPRHIAVLCDGNRRWARDAGYDDVSIGYRKGAAKIAEMLRWCQAAGIEMATIYLLSTENLQRDPDELTALIEIITDVVEEICAPYNKWSVRTVGDLELLGDEPARRLREAVESTTTKGANFHVNVAVAYGGRQEIVDAVRSLLSKELANGATAEQLIEAVTVDGISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTEAYWPAFRRVDFLRALRDYTARHRRFGK

Catalyzes the condensation of only one isopentenyl pyrophosphate (IPP) unit in the cis configuration to E-geranyl diphosphate (E-GPP) generating the 15 carbon product (2Z,6E)-farnesyl diphosphate (Z-FPP or EZ-FPP). Z-FPP is the precursor of decaprenyl diphosphate, which has a central role in the biosynthesis of the mycobacterial cell wall.

A0R2W4

P53378

TBG_YEAST

Gamma-tubulin

Saccharomyces

MGGEIITLQAGQCGNHVGKFLWSQLAKEHAIGTDGLSQLPDSSTERDDDTKPFFRENSRNKFTPRAIMMDSEPSVIADVENTFRGFFDPRNTWVASDGASAGNSWANGYDIGTRNQDDILNKIDKEIDSTDNFEGFQLLHSVAGGTGSGLGSNLLEALCDRYPKKILTTYSVFPARSSEVVVQSYNTILALRRLIEDSDATVVFDNASLLNISGKVFRNPNIDLQHTNQLISTIISSVTNSIRFPSYMYSSMSSIYSTLIPSPELHFLSPSFTPFTSDYIHDDIAHKGHSSYDVMLDLLDPSNSLVSTAMNNPTYFNVYNTIIGNVEPRQISRAMTKLQQRIKFPSWSSSAMHVNIGRRSPYLPLQPNENEVSGMMLSNMSTVVNVFENACNTFDKVFAKGAFLNNYNVGDLFQSMQNVQDEFAESREVVQSLMEDYVAAEQDSYLDDVLVDDENMVGELEEDLDADGDHKLV

Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly. TUB4 is an important spindle pole body component that organizes both cytoplasmic and nuclear microtubule arrays.

P53378

Q0HHM8

TOLB_SHESM

Tol-Pal system protein TolB

Shewanella

MKILAKWLALAVLLCTMPAKAALDIVITEGVDAARPIAVMPFQWQGAGAPPQAIADVVMSDLIRSGTFKPLDELGLPQRGIGALAQFDASAWANVGAEAVVVGSVKPYGTDQFLVSFDLIDLVKAQNQALKGPTSATEFLMDSRQTVISAAQFRQYGHRISDIVYEKLTGIRGAFLTRISYVVVNHSQKAAYSLMIADYDGYNEQMLLRSPEPLMSPSWSPDGRRLAYVSFENKKAEIFVQDLYTQVRTKVSSFPGINGAPTFSPDGKSLAVTLSKDGQPEIYVIDIATKAAKRITNHYSIDTEPSWYPDGKSLLFTSERGGRPQLYRVDLNSGKVTRETFEGEWNLGGSITPDGRSMIFVNRTNGKFNIARMDLSTRFMQVLTSTRLDESPSVAPNGTMVIYGTTYQGKQVLAAVSTDGRFKARLPVGQGEVKSPSWSPFL

Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.

Q0HHM8

Q88NN6

URODH_PSEPK

Hexuronate dehydrogenase

Pseudomonas

MTTTPFNRLLLTGAAGGLGKVLRERLKGYAEVLRLSDISPMAPAAGPHEEVITCDLADKAAVHTLVEGVDAIIHFGGVSTEHAFEEILGPNICGVFHVYEAARKHGVKRIIFASSNHTIGFYRQDERIDAHAPRRPDSYYGLSKCYGEDVASFYFDRYGIETVSIRIGSSFPQPQNLRMLCTWLSYDDLVQLIERGLFTPGVGHTIVYGASDNRTVWWDNRHAAHLGYVPKDSSETFRAAVEAQPAPAADDPSMVYQGGAFAVAGPFN

Catalyzes the oxidation of beta-D-galacturonate and beta-D-glucuronate to galactarate and D-glucarate, respectively.

Q88NN6

O84030

TRMD_CHLTR

tRNA [GM37] methyltransferase

Chlamydia

MEIDILSLFPDYFASPLQATILGRAIKQGALSVRSRDIREFGLGKWKQVDDSPYNGEGMLLMAEPVVQAIRSIRRKKSKVIYLSPQGQLLSAKKSRELASCSHLVLLCGHYEGIDERALTAEVDEEISIGDYVLTNGCAAALVLVDALARFIPGVLGNQESAEYDSLENGLLEGPQYTRPRVFEGESVPEVLLCGDHQKIADWRKQVSLERTRERRPDLYLQYFYGNSACLSTQEDLPRIEVVSPKTFSVVLEVQDLRKAKKFYSRMFGKECWDGDKLFLLGKTSLYLQQTKETRGPTTVFIELETDHDFVRFLKRWEILGGELGEQGTGGFPLRQVFDLDGHIWVVSCVQK

Specifically methylates guanosine-37 in various tRNAs.

O84030

Q17ZL5

Y048_HELAH

Nucleoid-associated protein Hac_0048

Helicobacter

MDFSQLSGLLDGVKKEFSQLEEKNKDTIYTSKSGGGMVSVSFNGVGELVDLQIDDSLLEDKEAMQIYLMSALNDGYKSVEENRKNLAFSMLGNFAKL

Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.

Q17ZL5

Q6FYF1

TSAD_BARQU

tRNA threonylcarbamoyladenosine biosynthesis protein TsaD

Bartonella

MRLLGIETSCDETAAAVIEHNIEGNSQILSNIVWSQTDNHAPYGGVVPEIAARAHVEILDDLILKALTDAHTKLKDIDAIAVTSGPGLIGGLLVGVMSAKALSLATGKPFIAVNHLEGHALTAVLTHNVAFPYLLLLVSGGHTQTILVHEVGNYQRLGTTIDDALGEAFDKTAKLLGLPYPGGPALEKAALLGDKNRISLPRPLKGEKRLDFSFSGLKTAVRQAATAMSPLTENDVADIAASFQAAVTDTVYDRVHLALQYFTHQYPLSHYKGRRPPALVVAGGVAANQAIRLTLQELAHQHGFEFIAPPLSLCTDNAAMIAFAGAQKFARGEKNSFDIAPRSRWPLDEKAAPLIGTGRRGTKA

Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

Q6FYF1

Q0SX94

ULAR_SHIF8

HTH-type transcriptional regulator UlaR

Shigella

MTEAQRHQILLEMLAQLGFVTVEKVVERLGISPATARRDINKLGESGKLKKVRNGAEAITQQRPRWTPMNLHQAQNHDEKVRIAKAASQLVNPGESVVINCGSTAFLLGREMCGKPVQIITNYLPLANYLIDQEHDSVIIMGGQYNKSQSITLSPQGSENSLYAGHWMFTSGKGLTAEGLYKTDMLTAMAEQKMLSVVGKLVVLVDSSKIGERAGMLFSRADQIDMLITGKNANPEILQQLEAQGVSILRV

Represses ulaG and the ulaABCDEF operon.

Q0SX94

Q7VQU0

UBIA_BLOFL

4-HB polyprenyltransferase

Candidatus Blochmannia

MYKRCIGFIKLMRVHQPVGFFLLLWPTLWALWITNRGIPDFIVLSLFIVGVMCMRSAGCVINDYIDYDIDMCVQRTIRRPIVIGSVKKQEALWVFFILILIALIVVCVFNNIIAVFLSLIVLGLSIIYPYLKRYIYLPQLVLGIIFSWSILIVYTVMNCAVNKTTWLLFLANTIWVVLYDTEYAMVDRDDDKCIGIKSSALLFGKIDKIVIGILQLLTVFILYIIGIVEQLPIIFYLFSIVGASILFIWQQVLIFNRNREKCLWAFLSNSYVGMLIFVGIVLSF

Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.

Q7VQU0

Q9Z964

TRMD_CHLPN

tRNA [GM37] methyltransferase

Chlamydia

MKIDILSLFPGYFDGPLQTSILGRAIKQRLLDVQLTNLRDFGLGKWKQVDDTPFSGGGMLLMAEPVTSAIRSVRKENSKVIYLSPQGALLTAEKSRELAAASHLILLCGHYEGIDERAIESEVDEEISIGDYVLTNGGIAALVLIDAVSRFIPGVLGNQESAERDSLENGLLEGPQYTRPREFEGKEVPEVLLQGDHKAISQWRLEQSERRTYERRPDLYLNYLYKRSIDHKFDEETTTNRDHFKCDKISVVLEVNKLKRAKNFYCKVFGLDAMSCENKFCLPHEGKTIFWLREVQAEKKNIVTLSLSLDCACEEDFCYLLRRWELFGGKLLEKQADEHAVWALAQDLDGHAWIFSWHRMK

Specifically methylates guanosine-37 in various tRNAs.

Q9Z964

P47370

THIO_MYCGE

Thioredoxin

Mycoplasma

MVTEIRSLKQLEEIFSAKKNVIVDFWAAWCGPCKLTSPEFQKAADEFSDAQFVKVNVDDHTDIAAAYNITSLPTIVVFENGVEKKRAIGFMPKTKIIDLFNN

Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.

P47370

A1CEK1

VPS27_ASPCL

Vacuolar protein sorting-associated protein 27

Aspergillus subgen. Fumigati

MAGWFSSSSPLDEQVERATSSSLEDIALNLEISDLIRSKSVQPKEAMRSLKRRLENRNPNVQIATLKLTDTCVKNGGTHFLAEIASREYLDNMVSLLTAEGAPLNSDVKEKMLELIQDWAMAAQGRMDLNYLGETYRKLQSEGFRFPPKSEISGSMLESSAPPEWIDHDVCMRCRTPFSFMNRKHHCRNCGNVFDAQCSSKTLPLPHLGILQPVRVDDGCYAKLTSKSFTPSTLSDRSAFKNNSITKANAMEPRGARAEGGFDDDLRRALQMSLEEAQNRGSGGYIPQPKVNEPSNATIQPHPQDEEDADLKAAIEASLRDMEEHKKKHAAALKNNTVATDSTAQDTGSALPMPKNPYELSPVEVENIHLFAALVDRLQHQPPGTILRESQIQELYESIGTLRPKLARSYGETMSKHDTLLDLHAKLSTVVRYYDRMLEERLSSAYSQHSLGYGQAPGGSQYPNMYPSMPSQAVEGKSGAENFYYGNAVPERSPPAHSTYAYQQGIAPSGPMSSGMYPQPGQALPSNPAWNGNAPPTTASPQLSTSSTPFPNHPVGYPAPSAPTQYYAPTAPPEQDANTYSTPRPGETEVSHQASPVMRRDSYYQSAGAPPSAPEPSPPSEHGQSSGYMQYADSRTMPPNSQYPPQQQPSAQPYYSQQPPPQATPHTTYSQPPAAPYETHPVADVSPIGAPVPSAPYQQPAPTRPAVEESLIEL

Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.

A1CEK1

P05823

TNR0_ECOLX

Transposon Tn2501 resolvase

Escherichia

MSRVFAYCRVSTLEQTTENQRREIEAAGFAIRPQRLIEEHISGSVAASERPGFIRLLDRMENGDVLIVTKLDRLGRNAMDIRKTVEQLASSDIRVHCLALGGVDLTSAAGRMTMQVISAVAEFERDLLLERTHSGIARAKATGKRFGRPSALNEEQQLTVIARINAGISISAIAREFNTTRQTILRVKAGQQSS

Resolvase catalyzes the resolution (a site-specific recombination) of the cointegrated replicon to yield the final transposition products.

P05823

Q12NB8

THIG_SHEDO

Thiazole synthase

Shewanella

MFTLADHTFSSRLLTGTGKFTNSHTMLASIVASESQIVTLAMKRIDLKLGQDDILTPLLAQGLTLLPNTSGARNAKEAIFAAELARDLLDTHWLKLEIHPDPKYLMPDPIETLLAAEKLCQMGFKVLPYVHADPVLCRRLEEVGCAAVMPLASPIGSNQGLATEAFLKIIIEQAKVPVIVDAGLGAPSQACRAMEMGADAVLVNTAIASSRSPIIMAKCFADAVKAGREAYLAGLGQVQPHASHTSPLTGFLQQMPAENTNTVEPL

Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.

Q12NB8

Q8FBI6

TATC_ECOL6

Sec-independent protein translocase protein TatC

Escherichia

MSVEDTQPLITHLIELRKRLLNCIISVIVIFLCLVYFANDIYHLVSAPLIKQLPQGSTMIATDVASPFFTPIKLTFMVSLILSAPVILYQVWAFIAPALYKHERRLVVPLLVSSSLLFYIGMAFAYFVVFPLAFGFLANTAPEGVQVSTDIASYLSFVMALFMAFGVSFEVPVAIVLLCWMGITSPEDLRKKRPYVLVGAFVVGMLLTPPDVFSQTLLAIPMYCLFEIGVFFSRFYVGKGRNREEENDAEAESEKTEE

Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.

Q8FBI6

Q8FAJ3

ULAA_ECOL6

Ascorbate-specific permease IIC component UlaA

Escherichia

MEILYNIFTVFFNQVMTNAPLLLGIVTCLGYILLRKSVSVIIKGTIKTIIGFMLLQAGSGILTSTFKPVVAKMSEVYGINGAISDTYASMMATIERMGDAYSWVGYAVLLALALNICYVLLRRITGIRTIMLTGHIMFQQAGLIAVTLFIFGYSMWTTIICTAILVSLYWGITSNMMYKPTQEVTDGCGFSIGHQQQFASWIAYKVAPFLGKKEESVEDLKLPGWLNIFHDNIVSTAIVMTIFFGAILLSFGIDTVQAMAGKVNWTVYILQTGFSFAVAIFIITQGVRMFVAELSEAFNGISQRLIPGAVLAIDCAAIYSFAPNAVVWGFMWGTIGQLIAVGILVACGSSILIIPGFIPMFFSNATIGVFANHFGGWRAALKICLVMGMIEIFGCVWAVKLTGMSAWMGMADWSILAPPMMQGFFSIGIAFMAVIIVIALAYMFFAGRALRAEEDAEKQLAEQSA

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport.

Q8FAJ3

A8F821

THIC_PSELT

Pseudothermotoga

MTQMEIAQKGTSSEEMKRVAEYEEMNLEVIRQKLAYGKAVLPKNKLHKIEKPMIVGEGFTVKVNANIGTSQAFFSLEEEKEKARVAIEYGADSLMVLSTWGDLKEIRKAIIDLSAVPVGSVPIYDSAMKSYQLKKNVVDFSEKDFLNMVISHAEDGIDFMTIHAGITKKVLEHVKNSGRILKVVSRGGAIIAGWMIKNNKENPFYEYFDELLDIAKDYDITLSLGDGMRPGTVLDASDVQQFEELFVMRELVEKAREKGVQVMLEGPGHIPLNEVELNVKLMKKIGEDAPIFLLGPLPTDRAMGYDHIACAIGGALAGYYGADFLCYVTPSEHISLPTIEDVREGVIASKIAAAIADLARGNRKAWWLEKQMALSRKNFNWEEMFKLSLGKDLARKKYKERPYLHEGCSMCGPFCAIKIVEEFF

Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

A8F821

P34710

UNC6_CAEEL

Uncoordinated protein 6

Caenorhabditis

MITSVLRYVLALYFCMGIAHGAYFSQFSMRAPDHDPCHDHTGRPVRCVPEFINAAFGKPVIASDTCGTNRPDKYCTVKEGPDGIIREQCDTCDARNHFQSHPASLLTDLNSIGNMTCWVSTPSLSPQNVSLTLSLGKKFELTYVSMHFCSRLPDSMALYKSADFGKTWTPFQFYSSECRRIFGRDPDVSITKSNEQEAVCTASHIMGPGGNRVAFPFLENRPSAQNFENSPVLQDWVTATDIKVVFSRLSPDQAELYGLSNDVNSYGNETDDEVKQRYFYSMGELAVGGRCKCNGHASRCIFDKMGRYTCDCKHNTAGTECEMCKPFHYDRPWGRATANSANSCVACNCNQHAKRCRFDAELFRLSGNRSGGVCLNCRHNTAGRNCHLCKPGFVRDTSLPMTHRKACKSCGCHPVGSLGKSCNQSSGQCVCKPGVTGTTCNRCAKGYQQSRSTVTPCIKIPTKADFIGSSHSEEQDQCSKCRIVPKRLNQKKFCKRDHAVQMVVVSREMVDGWAKYKIVVESVFKRGTENMQRGETSLWISPQGVICKCPKLRVGRRYLLLGKNDSDHERDGLMVNPQTVLVEWEDDIMDKVLRFSKKDKLGQCPEITSHRY

Component of an extracellular matrix cue that guides dorsoventral migrations on the epidermis . Required for the guidance of pioneer axons and migrating cells along the body wall . In particular, it is required for the guidance of axons from neurons, including SubL neurons and AIY interneurons, into the nerve ring . During gonad morphogenesis, involved in distal tip cell (DTC) migration from the dorsal side of the hermaphrodite body to the midbody to allow for formation of gonad arms . Its association with either unc-40 or unc-5 receptors will lead to axon attraction or repulsion, respectively . Involved in dendritic morphogenesis; may act by association with unc-40 at the tips of growing dendrites for interaction with unc-5 on the apposing branch to induce mutual repulsion . Involved in the positioning of ray 1, the most anterior ray sensilium, in the male tail . Required for the formation of synapses between the AVA interneurons and the PHB sensory neurons .

P34710

V9QFH8

TXA2_STEGR

Latrodectin-2

Steatoda

MFKLICIVFIATILSITSAADNEDELTIEDFLSYECNESMDIEELKEKDKVCSRCANLHKTQSVIERCRLNCFTSEYFKNCEDNLQAKEEEPEEETL

May increase the toxicity of alpha-latrotoxin and/or other venom components. Is non-toxic to mice and to the cockroach Periplaneta americana.

V9QFH8

Q6C705

TRM82_YARLI

Transfer RNA methyltransferase 82

Yarrowia

MKHPYHIVSLSPDGKTMYAAAARQVDRICLETGECKSTVVEESATRTTTKTGDKPAAAKRTKYLPTSVSHVRSLQLSKGGKYLLATTDETKSLVLLDPTTLEVIKKVQYPKRPSAVATDKEDLNIVLGDKFGDVYGESVEDLLKVEGELKDEPVLGHVSMLTALELGYDSKDRPYVISADRDEHIRISRFPASHVIEQFCFGHQQFVSSLLINDLDASILFSAGGDDEIFVWDWLNGKQLQKLSLREHVESYLNEAHIYVDKKGVATTHKEITVSSLQQIKDTPYLLVNVESTNAIIVLKIVDNKLEVASVFATEAHVISFSVAGNLLVTSEVGSEGVKAYTITDGVVTKSDKEIPFGSCEYEDDSELISLFSTKSLRKRGEF

Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.

Q6C705

Q81XH4

YIDC1_BACAN

Membrane protein YidC 1

Bacillus cereus group

MLKSYRAVLVSLSLLLVFVLSGCSNATPIDAHSTGIWDHYFVYPISFMIQFVAHHIPGASFGIAIIIMTLVIRSAMIPLAVSQYRSQAKMKKMQPELQKLKQKYGDVSKDLEKQKQYQKEMSELMKSGGWNPLAGCWPLLIQMPIFSALYYAISRTEEIRTSTFLWVNLGHADPYHILPIIAALTTFIQMKVFQSNSTSGEQVQMLKMQQIMMPAMILFMGFAAPSGLVLYWITGNLFTMMQTIVLRKIMEREELQLQKA

Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.

Q81XH4

A1A1N2

TPIS_BIFAA

Triose-phosphate isomerase

Bifidobacterium

MGPKRIPLVAGNWKMNFDHLEATYFVQQLAWNLRAIHFDYKRCEIALMPSFTSLRSVQVAVESDNLKIRYGAQAVSVTSQGAFTGDVSADMIAHLGCSYVIVGHSERRKYHPEDDANIVDQVRAVLAAGMQPILCVGESYEERRKGIELDFAVGQVHDVTRDLSDEEAAKLIVAYEPVWAIGTGMVATPQSAQDAARAIRNDLSDTFGTRVGETVRILYGGSVSSKNAVELINEPDVDGFLIGGSALKVDELTRICKLTLETTA

Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

A1A1N2

A5DH87

TVP38_PICGU

Golgi apparatus membrane protein TVP38

Meyerozyma

MPRLHSASEPPATGFFARVRNELGNRTEGLHQINNQALDWYRSQSQIRQILIQIGGVVAIVIGVLVLIFHKYLIELLVIISDDWAKLPGGRLILFLLVFFVGFPPLIGYSALSLLAGMVYGFPYGWPLLASASVSGSFVAFLVFRYFLRSQGERLVNSNEKFRAFAEILREDSSLFLLVLIRLCPLPYSLSNGALAAIPELSAWVYLGASVITSPKMLIHLFVGHKIKEFGDAKTDTSTKIIDVISILVTGAAASLTTFIIYRKMQQKLHHNRAGANYDAFVFGNFDDLESGTNVELNSADFDQDNFIITDDELEEEEPNGSHTATATQVQVARRNCSKAMTICTLMFV

Golgi membrane protein involved in vesicular trafficking and spindle migration.

A5DH87

C5BAT7

ZAPA_EDWI9

Z ring-associated protein ZapA

Edwardsiella

MSAQPVDIQIFGRALRVNCPPEQLDALNQAAEDLNQRLQDLKVRTRVTNTEQLVFIAALNVCHELAQERLKTRDYAANMEQRIRMLQQTIEQALLEQGRITERPGTSFE

Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division.

C5BAT7

O57486

TDT_AMBME

Terminal deoxynucleotidyltransferase

Ambystoma

MYAFPTTRIAPRRKQPKCIKPPKCTSKYDIKFKDIAIYILERKMGASRRYFLMELARKKGFRVEPDLSEYVTHVVSEKNSGAEVLEWLQAKKAGSIPNVAILDISWFTDCMGAGQPVEIERKHRLTLQKICVCKSPSPVVPSRVGVSQYACQRKTTLDNKNTLFTDAFEILAENYEFRENERSCLSFRQAASVLKSLTFTIAGMADVDGLPGFGDHIRAVIEDLIEDGESSKVSEVLNDEVYRSLKLFTTIFGVGLRTAEKWHRLGIRTLEEIKSNENLKFSKMQIAGLQHYEDILGGVRKAEADAVAMVVRDAVWTFLPDAVVTLTGGFRRGNKTGHDVDMLITSPIQGKEKELLHKVINLWKKQDLLLCHTIHESTMDEDNLPSKSVNLLDHFQKCFAILKSNQHRGEISSCDGPHDSRERGKRIWKAIRVDLVFCPFEQYAFALLGWTGSRQFERDLRRYASHEKKMMIDNHALYDKTKRVFVKCESEEEIFGHLGLEYIDPVERNA

Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.

O57486

B2UW67

UREE_HELPS

Urease accessory protein UreE

Helicobacter

MIIERLIGNLRDLNPLDFSVDYVDLEWFETRKKIARFKTRQGKDIAIRLKDAPKLGLSQGDILFKEEKEIIAVNILDSEVIHIQAKSVAEVAKICYEIGNRHAALYYGESQFEFKTPFEKPTLALLEKLGVQNHVLSSKLDSKDRLTVSMPHSEPNFKVSLASDFKVVMK

Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly.

B2UW67

Q9P4D3

TPS2_ZYGRO

ZrTPS2

Zygosaccharomyces

MVNSGHRRQRIINCVAQLPYKIQLGETNDEWNIVPATGSSSLYSSIEYLNSEEKAKDYEQHVLGWTGEIGRESLPSRLFNSKNRDKSENGEKGENDLHAKEEREKEEDPLYLTNDQIDGITKDLRRHGKSDDHYNVDNVHPVWLLRRDQKRWRGFAENVLWPTFHYILKFSSDSGEKENLSWYDYVRFNEAYAMKIGEIYEKGDIIWIHDYYLLLLPQLLRMKFNDQDLTIAYFHHSPWPSNEYFRVLPRRKQILDGLMGADRGWFQNEGFARHFVSSCKRLLDSTSRKSKNRLGMEQYQISAYGGDIVVDSLPIGINRVKLLEDTFTKDIAQKVLAIKDAFQGKKIIVGRDRLDSVRGVVQKLRAFETFLSMYPEWRDQVVLIQVSVPSMKGGTNQLIRLEQQVNELVTSINMQYGSLNFSPVHHYYMRIPKDVYLSLLRVADLCVIASVRDGTNTTALEYVTVKSHMSNYNCYGNPLILSEFSGTSTILKDAMIINPWDSVAVAKSINRALSLSRDEKRALEDKIWPQVPTIQKWTDQFLSTLSDIVDEAHNTTDRKMTPALNRPALLEHYRQSKRRLFLFDYDGTLTPIVQDPAAAIPSARLISILQKLASDPCNQIWIISGRDQAFLNKWLGSRLPQLGLSAEHGCFYKDVDEENWINLTEKFDMSWQEKVGSIMEEFTRRTPGSFIERKKVALTWHYRRADPELGEFYASELKKELDKICADYDLDVMEGKANIEVRPKFVNKGEIVKRLVWHHHGRRQDMLNTKKEELPISEMPDFTLCLGDDFTDEDMFNQLNDIEAVWKKQYEDEVNQWGGFGLYPCTVGSASKKTVAKAHLTDPQQVLDTLGLLVGDVSLFQSAGTVELDSRGHVKHSDSSIRSEQASARYAMKRQQSYKN

Phosphatase catalytic subunit of the trehalose synthase complex that catalyzes the production of trehalose from glucose-6-phosphate and UDP-alpha-D-glucose in a two step process.

Q9P4D3

A4XYV5

THIE_PSEMY

Thiamine-phosphate pyrophosphorylase

Pseudomonas

MTAALRGLYAITDTPLLAGGKLLPYAEAALIGGARLLQYRDKSGDAVRRLDEAQALAELCQRHGATLIINDDLELAAHLGVGLHLGQTDGSLAAARARLGADVVIGGTCHAQLELAERAVAEGASYIAFGRFFNSNTKPGAPAATVELLDQARTRFAQPIVAIGGVTLDNAPGLIARGASMVAVIHALFAADSALEVQDRARAFAALFD

Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

A4XYV5

B4R966

YQGF_PHEZH

Putative pre-16S rRNA nuclease

Phenylobacterium

MAVVDLIDLPAIAPPNTPLVGLDLGEKTIGVAVSDATRMVASPLGLIRKTKFTDDAKALFKLMESRRASGIVIGLPVNMDGTEGTRCQSNRAFARNLLRLREDLPIAFWDERMSTMAVNRMLVGEADMTRARRADVVDKMAAAWILQGALDRLRNL

Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.

B4R966

Q64P45

TRMB_BACFR

tRNA(m7G46)-methyltransferase

Bacteroides

MGKNKLEKFADMASYPHVFEYPYSAVDNVPFDMKGKWHKEFFKNDNPIVLELGCGRGEYTVGLGRMFPDKNFIAVDIKGARMWTGATESLQAGMKNVAFLRTNIEIIDRFFAEGEVSEIWLTFSDPQMKKATKRLTSTYFMERYRKFLVSNGIIHLKTDSNFMFTYTKYMIEENGLPVEFITEDLYHSDLVDDILGIKTYYEQQWLDRGLSIKYIKFLLPQEGELREPDIEIELDSYRSYNRSKRSGLQTSK

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.

Q64P45

Q6MTM6

TMFO1_MYCMS

Folate-dependent tRNA(M-5-U54)-methyltransferase 1

Mycoplasma

MKTIRIIGAGLSGCEAAYYLLKKGYFVELYEIKTIKKNPIQHYDYFCELAYSDSFRSTDLNTSVGTLKKELELLDSLIIKAAKYASINQNNELVVNRIEFSKYITNYLKTFNNLKIIEQEYLNIDLNIPTIIAIGPISTPSFLTNLKKIINKKNLKLFDTVEPTILKQSINKNICYSLDNNLDYLYCDLNKEQFEKFYNALISAKTFNSPLKNEIKLLEKNNYFSIESLAKNKQEFINHFKPINNNAYITITLKKDSVIDNLYTIVNFQTSLMWNEQLKVFSLIPGLENLKIMRYGVMHKNNYINTKKLLNLGVQLKTNKNIFFAGQIIGVDGYVESVCSGLISAINLDRYLNNKKMILPNKNSTIGSLYNYLLKTDSNFNPMRINWALVDLIDGFELSDNSKKFYSKRAIELIKQYLKKINYK

Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.

Q6MTM6

Q92GI1

YBEY_RICCN

Endoribonuclease YbeY

spotted fever group

MINVEIVRNYNKWREHKQINKSLIKKITQNILLRFDNFSKIKQFELSILLTNAAEILTLNKQFRNIEKATNVLSFPSNELNWQDLYSKLEFLGDSDYMHLGDIAFCYEVIYNESCEQHKTFENHFIHLLIHSILHLIGFDHQNDTEANIMENLEIEILSYFGIFPPY

Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

Q92GI1

Q5L5L8

TRMD_CHLAB

tRNA [GM37] methyltransferase

Chlamydia

MKIDILSLFPEYFDSPLRSSILGRAIKRGLLDIQSRDIREFGLGKWKQVDDAPFNHDGMLLMAEPVVKAIRHVKRSDSKVVYLSPQGQLLTAKKSRELAQCSHLIFLCGHYEGIDERALESEVDEEISIGDYVLTNGGIAALVVIDALSRFIPGVLGNQESADKDSMENGLLEGPQYTRPRVFEGREVPEVLLHGDHQAIAKWRKQISLDRTRERRPDLYIRYLYDRENEEVTQQETDLKQSMLEGESAVILEVEDLHRSRKFYSKMFRLNQPVNNRLHIPGKTQMTIHLQEVGLKSKNIVLLSLRLGCKDDFFSFLGRWKMLGGTLEQADDRGEVRLVRDFDGHVWAISCKQAE

Specifically methylates guanosine-37 in various tRNAs.

Q5L5L8

Q9HSG5

TRUD_HALSA

tRNA-uridine isomerase D

Halobacterium

MREAHPIERAVGMAYYASDSDGTGGRLRDSPADFRVRELEAFDTQPADAPTGDYPWLVVRATLHEWDTNDFARELANTVGMSRERVRWAGTKDRHAVTTQLFAVRDLDAAQVPEIRNADIEVVGRAGRGLEFGDLAGNAFEIVVRDPDAPERAAAVADELAAFGGGTVGTPNYFGQQRFGSKRPVTHEVGLAILRDDWEAAAMAYLGAPTEHEPADSQRAREYVAETRDWTGALAEFPQRLRYERTMLHELADGGSFRDAVETFPSNLQQLFVHAAQSYVFNRIVSERMARGLPFGEPVAGDVVWFADSDADAAVAQPDAARQQRVTDSRVDVMARHCERGRAFVTAPLVGTDTEFADGDPGEITRGVLDDLGLSRADFDLPGEFDSAGSRRAILLRPDLTVSHDPLAFEFALPSGSYATVVLREFLKPSPLAL

Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

Q9HSG5

Q9FPH3

THA2_ARATH

Threonine aldolase 2

Arabidopsis

MVTPTTIRTVDLRSDTVTKPTESMRSAMANAEVDDDVLGNDPTALRLEKEVAEIAGKEAAMFVPSGTMGNLISVLVHCDERGSEVILGDDSHIHIYENGGVSSLGGVHPRTVKNEEDGTMEIGAIEAAVRSPKGDLHHPVTKLICLENTQANCGGRCLPIEYIDKVGELAKKHGLKLHIDGARIFNASVALGVPVKRIVQAADSVSICLSKGIGAPVGSVIVGSKKFITKARWLRKTLGGGMRQIGVLCAAALVALHENVAKLEDDHKKARVLAEGLNRIERLRVNVAAVETNIIYVDIPEDPKFGAEEACKSLEDVGVLVIPQATFRIRIVLHHQISDVDVEYVLSCFEKIFHS

Threonine aldolase involved in threonine degradation to glycine. May play a role in the removal of L-allo-threonine.

Q9FPH3

B3EE09

THIC_CHLL2

Thiamine biosynthesis protein ThiC

Chlorobium

MNTFSDNIFCPEHRMYGNASKKTHTKGCIHPIEVGMRTLSLTKTYTCRGIEFSSIPLYDTSGPYSDPSVIINPEKGLNPLRDKWKFNSENTEPVSEQGNETAAARVPLRAKKGCSVTQLAFARKGIITPEMEYVAIRENQQLEEWIASFPIGGKTAEPFTAEFVRQEVAAGRAIIPANINHPELEPMIIGRNFRVKINANIGNSAMGSSIEEEVEKAVWACRWGADTVMDLSTGTNIHQTREWILRNSPVPIGTVPMYQALEKAGGVAENLTWELYRDTLVEQAEQGVDYFTIHAGILQEHLPAAGRRMTGIVSRGGAIMAKWCKTNNRENFLYTHFDEICEILRSYDIAISLGDALRPGCIADANDEAQFGELKVLGELTLLAWEHDVQVMIEGPGHVPLNLVEENMRKQLELCHGAPFYTLGPLITDIAAGYDHINSAIGGTLIAAYGCSMLCYVTPKEHLGLPDKNDVREGVVVHKVAAHAADIAKGNPTAWLQDELMSRARYAFAWEDQFNLSLDPVKARVLYAESRAASGQTDGNPDFCTMCGPDFCSMKRSQEK

Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

B3EE09

A0AJ83

TRPD_LISW6

Anthranilate phosphoribosyltransferase

Listeria

MESLLQKVYDQENLTKAEMNILATEIFEGRLSKTKMAAFLMALKVKGETAEEMAGIAEAMQEVAIQVAFPAGTAMDNCGTGGDKSNSFNISTTSAFVLAAAGIPVAKHGNRSISSRSGSADVCQELGIDINMRPEDMTYLLEKVGIAFLFAPHVHPNMKYVMDVRKELGTPTIFNLIGPLTNPVHLETQLMGIYRRDLLKQTAEVLGQLGRKRAVVLNGAGFMDEASLAGENHYALYESGEVQLFTLSPEEVGLANYPLEAIRGGDAKENAAILRSVLEGEPGAHLDTVLLNAGFGLFASGKVATVKEGVNLARDLVRSGLAKQKLADLITYQKEVLTK

Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).

A0AJ83

Q03A83

TARI_LACP3

Ribitol-5-phosphate cytidylyltransferase

Lacticaseibacillus

MITAIVLAGGVGKRMGMEIPKQFVMVNEKPIIIYTLESFDRHPKIDQVVVVCKQGWADTMWGYIREFGIKKVKWVISGGSIVQKSINNAVQFLSDKCVEDDIVVIHDGIRPLVDEHVLSDVIVKCQEYGNAVTSLPYNEQIFIKETEKTTNKYIDRNTLRRVSTPQAYKYEVLHDAYDEAISQNIGMVDSAYTNTMMVDLGHTLYFAAGSDKNIKLTTTDDLALFKAYLREKEL

Catalyzes the transfer of the cytidylyl group of CTP to D-ribitol 5-phosphate.

Q03A83

O32125

YUTF_BACSU

5'-nucleotidase YutF

Bacillus

MKTYKGYLIDLDGTMYNGTEKIEEACEFVRTLKDRGVPYLFVTNNSSRTPKQVADKLVSFDIPATEEQVFTTSMATAQHIAQQKKDASVYVIGEEGIRQAIEENGLTFGGENADFVVVGIDRSITYEKFAVGCLAIRNGARFISTNGDIAIPTERGLLPGNGSLTSVLTVSTGVQPVFIGKPESIIMEQAMRVLGTDVSETLMVGDNYATDIMAGINAGMDTLLVHTGVTKREHMTDDMEKPTHAIDSLTEWIPYI

Catalyzes the hydrolysis of various purine and pyrimidine 5'-nucleotides, showing preference for 5'-nucleoside monophosphates and exhibiting the highest catalytic activity toward 5'-XMP . Shows also a relatively high phosphohydrolase activity toward the nucleotide precursors ribose-5-phosphate (R5P) and 5-phosphoribosyl-1-pyrophosphate (PRPP), and toward the non-natural substrate p-nitrophenyl phosphate (pNPP) .

O32125

B0U620

UNG_XYLFM

Uracil-DNA glycosylase

Xylella

MNEQGEAINSSAESRIQLESSWKAHVGNWLLRPEMRDLSSFLRARKVAGVSVYPPGSQIFAAFEATPFQRVKAVILGQDPYHGQGQAHGLCFSVRPGMPLPPSLLNIYKELEEDLGLLRPDHGCLLPWANRGVLLLNAVLTVEDGRAGAHQGKGWEGFTDHVVDTLNREREGLVFMLWGSYAQAKGKVIDTRRHLVLKAPHPSPLSAHRGFLGCRHFSLCNQYLSQHGLGMVDWSLPPCIALDGAILNGRIAV

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

B0U620

P60938

UPPP_GEOSL

Undecaprenyl pyrophosphate phosphatase

Geobacter

MDIMHAAVLGILQGLTEILPISSSAHLILVPWLLGWPESGLTFDVGLHVGTLIALCVYFRRDIAYLISDAITGLREGFGSQTSRLPFFIIAGTVPAAIAGKTLEKPIEEFFRGSHTLIALLLIAFGLLLALADTTGPKRWRMDRVDLRGALLIGLAQCLALIPGVSRSGITITAALFLGFTRDTAARFSFLLSLPIVAGAGILKMGELARHGIPAGELAPLLAGMATSAVSGYLGVALLLRLVQRYSLYPFVWYRLLAGGAVLAYLFAR

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.

P60938

Q6S9E0

TTP_SHEEP

Zinc finger protein 36

Ovis

MDLAAIYKSLLSLSPELPSDLGETESSTSWASSGPWSLSSSDSSLPEAAARLPGRSTSLVEGRSCGWVPPPPGFAPLAPRPSSELSPSPTSPTATPTTSSRYKTELCRTFSESGRCRYGAKCQFAHGLGELRQPSRHPKYKTELCHKFYLQGRCPYGSRCHFIHNPSEDLAAPGHPHVLRQSISFSGLPSGRRTSPPPASLAGPSVPSWSFSPSSSPPPPPGDLPLSPSAFSAAPGTPVSRRDPTPACCPSCRRATPNSVWGPVGGLARSPSAHSLGSDPDEYASSGSSLGGSDSPVFEAGVFGPPQPPAAPRRLPIFNRISVSE

Zinc-finger RNA-binding protein that destabilizes numerous cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as an 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation. Functions also by recruiting components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs. Self regulates by destabilizing its own mRNA. Binds to 3'-UTR ARE of numerous mRNAs. Binds also to ARE of its own mRNA. Plays a role in anti-inflammatory responses; suppresses tumor necrosis factor (TNF)-alpha production by stimulating ARE-mediated TNF-alpha mRNA decay and several other inflammatory ARE-containing mRNAs in interferon (IFN)- and/or lipopolysaccharide (LPS)-induced macrophages. Also plays a role in the regulation of dendritic cell maturation at the post-transcriptional level, and hence operates as part of a negative feedback loop to limit the inflammatory response. Promotes ARE-mediated mRNA decay of hypoxia-inducible factor HIF1A mRNA during the response of endothelial cells to hypoxia. Positively regulates early adipogenesis of preadipocytes by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA. Plays a role in maintaining skeletal muscle satellite cell quiescence by promoting ARE-mediated mRNA decay of the myogenic determination factor MYOD1 mRNA. Associates also with and regulates the expression of non-ARE-containing target mRNAs at the post-transcriptional level, such as MHC class I mRNAs. Participates in association with argonaute RISC catalytic components in the ARE-mediated mRNA decay mechanism; assists microRNA (miRNA) targeting ARE-containing mRNAs. May also play a role in the regulation of cytoplasmic mRNA decapping; enhances decapping of ARE-containing RNAs, in vitro. Involved in the delivery of target ARE-mRNAs to processing bodies (PBs). In addition to its cytosolic mRNA-decay function, affects nuclear pre-mRNA processing. Negatively regulates nuclear poly(A)-binding protein PABPN1-stimulated polyadenylation activity on ARE-containing pre-mRNA during LPS-stimulated macrophages. Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion. Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis. Plays a role as a tumor suppressor by inhibiting cell proliferation in breast cancer cells.

Q6S9E0

A5WDG7

TRPA_PSYWF

Tryptophan synthase alpha chain

Psychrobacter

MTRIESTFETLKAQNKKALIPYVMAGDPSPNSFVDLLHDLVKHGADMIEVGLPFSDPMADGPTVALAGERALAGGTSTHQALAIVKKFREQDSSTPIILMGYLNPIEIIGYEAFIALCHESGVDGVLVVDLPPAESGNFVERLAAHDINKIFLLSPTTLPERRKQVMTHCGGYIYYVSLKGVTGSASLDTQAVGEQVQAIKQETNLPICVGFGIRDGQSAAAIGQYADGVIVGSELVKNFSGLSHTSRAEDIATAQASIMTKMDELRQALDALSA

The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

A5WDG7

Q9KS29

TTCA_VIBCH

tRNA 2-thiocytidine biosynthesis protein TtcA

Vibrio

MTAQTQELTKAQQYNFNKLQKRIRRNTGQAIADFNMIEDGDRIMVCLSGGKDSFTMLDILMSLQKSAPISFELVAVNLDQKQPGFPEHVLPEYLESLGVEYKIVEEDTYAIVQDKVPEGKTTCALCSRLRRGILYRTAKELGATKIALGHHRDDILETLFLNMFYGGKMKGMPPKLVSDNGEHVVIRPLAYCREKDIIKYSDMRGYPIIPCNLCGSQPNLQRQAVKQMLNDWDKRFPGRIETMFRAMQNVVPSHLADFSLFDFKSIDKNSGVINGGDIGFDKEEIAPQVVEDEDLVMEFDPSLQLNVTNI

Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.

Q9KS29

B0SB32

YBEY_LEPBA

Endoribonuclease YbeY

Leptospira

MNPSLSVFTHWNDESNQSEIFSDPVISNCEKILRFLAPEFLHSLELSIYLVNDSLMAEINEERRGKPATTDVLSFPLYSEHPPIPVQILGEVVISMETCKKQAMEIGHGLVDEFYRLLVHGILHNFGYDHETNEEDALLMRKMEDECLDLVFAT

Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

B0SB32

Q5CZA5

ZN805_HUMAN

Zinc finger protein 805

Homo

MAMALTDPAQVSVTFDDVAVTFTQEEWGQLDLAQRTLYQEVMLENCGLLVSLGCPVPRPELIYHLEHGQEPWTRKEDLSQGTCPGDKGKPKSTEPTTCELALSEGISFWGQLTQGASGDSQLGQPKDQDGFSEMQGERLRPGLDSQKEKLPGKMSPKHDGLGTADSVCSRIIQDRVSLGDDVHDCDSHGSGKNPVIQEEENIFKCNECEKVFNKKRLLARHERIHSGVKPYECTECGKTFSKSTYLLQHHMVHTGEKPYKCMECGKAFNRKSHLTQHQRIHSGEKPYKCSECGKAFTHRSTFVLHNRSHTGEKPFVCKECGKAFRDRPGFIRHYIIHSGENPYECFECGKVFKHRSYLMWHQQTHTGEKPYECSECGKAFCESAALIHHYVIHTGEKPFECLECGKAFNHRSYLKRHQRIHTGEKPYVCSECGKAFTHCSTFILHKRAHTGEKPFECKECGKAFSNRADLIRHFSIHTGEKPYECMECGKAFNRRSGLTRHQRIHSGEKPYECIECGKTFCWSTNLIRHSIIHTGEKPYECSECGKAFSRSSSLTQHQRMHTGRNPISVTDVGRPFTSGQTSVNIQELLLGKNFLNVTTEENLLQEEASYMASDRTYQRETPQVSSL

May be involved in transcriptional regulation.

Q5CZA5

Q0VLN5

UBID_ALCBS

Polyprenyl p-hydroxybenzoate decarboxylase

Alcanivorax

MKYRDLRDFISQLEQLGELKRITVPVDPKLEMTEICDRTLRAGGPALLFENPVGFGTPVLGNLFGTERRVALGMGRDSVAELRELGELLAFLKEPEPPKGFRDAWEKLPVFRKVLSMSPKVSSSGPCQEKVLEGDEVDLYKLPIQTCWPDDAGPLVTWPLVITRGPNKERQNLGIYRQQLIGRNKLIMRWLSHRGGALDFQEWQQQHPGEPFPVSVALGADPATILGAVTPVPDTLSEYAFAGLLRGSKTELVKCIGNDLQVPASAEFVLEGFLYPGDMADEGPFGDHTGYYNEVERFPVFTVERITHRRNPIYHSTYTGRPPDEPAVLGVAMNEIFVPILKKQFPEIVDFYLPPEGCSYRMAVVTMKKQYPGHAKRVMMGVWSFLRQFMYTKFVIVCDDDVNARDWKDVIWAMTTRMDPARDTVMIENTPIDYLDFASPVAGLGSKMGMDATNKWAGETTREWGRAIAMDPAVKTRVDEMWSSLGIDTPE

Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.

Q0VLN5

Q0HE99

UBIB_SHESM

Ubiquinone biosynthesis protein UbiB

Shewanella

MTLASIRRGYHVIKTLLQYGLDDVLPPKMTPWYFKLARNSLFWIRNKHKGKSGGERLKLAMQELGPVYIKLGQMLSTRRDLLSDEWANELAMLQDKVPPFDGALARQAIETELKAPIESFFDDFNETPLASASISQVHTATLKSNGKAVVLKVLRPNVEAKIQADLLLMSQTAKIIDYLLGEGNRLRPSEVIEDYRVTILGELNLKLEALNAIKLRNNFLDSDALYIPYVYEEFCYPRLMVMERIYGIPVSDIAALKAQGTNFKLLAERGVELFFTQVFRDNFFHADMHPGNIFISRDHPENPYYIGLDCGIMGTLSEVDKRYLAENFLAFFNRDYHRIAQLYIESGWVSEKTDLQAFEQAIKVVCEPMFNKPLDEISFGHVLLELFRTARHFDIVVQPQLVLLEKTLLYIEGLGRQLYPQLDLWQTAKPFLEQWMAEQVGPKAMFKKVSTKLPYWSDKLPEFPELIYDNLKLGRKLLSSQQQMLDKYLKYQQQAHKSNYLLITSAILLICGTLLFNQDATLWSPYVCLISGAALWIIGWRSRPKNRKF

Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis.

Q0HE99

Q0ASJ7

TRUA_MARMM

tRNA-uridine isomerase I

Maricaulis

MPRYRITIEYDGRPFSGWQRQDNAPSVQESLERAAEKLDGAPVLVYGAGRTDSGVHALAQVAHLDLAKDLSTDKVRDAINYHLKPDPVAVIEAARVSDDFHARFSATRRHYLYRMIDRRAPLTLDRGQVWRVTRKLDAEAMHHAAQALLGQHDFTTFRDAQCQAESPVKSLDAISVSRYGEEVQLTCSARSFLHRQVRSMVGSLVEVGVGKWSARDFKRALDAADRSRCGPVAPADGLYLTAVDYPGPA

Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.

Q0ASJ7

Q68W09

YBEY_RICTY

Endoribonuclease YbeY

typhus group

MINVEIVRNYNKWREHRKINKGLIKKITQNVLVRFDHFDKIKQFELSILLTNTAEILTLNQQFRSIEKATNVLSFPNNELNWHNLYSKLEFLYYSDYMHLGDIAFCYEVIYNESCEQQKTFENHFIHMLIHSILHLIGFDHQNDTDANIMESLEIEILSYFGIPSPY

Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

Q68W09

A5V9W7

TRPA_RHIWR

Tryptophan synthase alpha chain

Rhizorhabdus

MTRLAETFARTRAEGRAALVTFVTGGDPTPGDMGPILDALVAGGADVIELGMPFTDPMADGPAIQRANLRALGAGTTTADLLAIAAAFRQRHPSVPLVLMGYANPMVRRGPEWFAAEAAKAGVDGVICVDIPPEQDGALGPALRAAGVAPIRLATPTTDAARLPAVLEGASGFLYYVSVAGITGMQQAGQASIEAAVARFKAATDLPVAVGFGVRGPEQAEAIGRVADGVVVGSAIVDLIGEHGAAAAGPVRDFTATLSAALRRAAQEKAA

The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

A5V9W7