Datasets:

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Prot2Text-Data

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B7LNJ1

LPLT_ESCF3

Lysophospholipid transporter LplT

Escherichia

MSESVHTNTSLWSKGMKAVIVAQFLSAFGDNALLFATLALLKAQFYPEWSQPVLQMVFVGAYILFAPFVGQVADSFAKGRVMMFANGLKLLGAASICFGFNPFVGYTLVGIGAAAYSPAKYGILGELTTGDKLVKANGLMEASTIAAILLGSVAGGVLADLHVLVALAACALAYAGAVAANIYIPKLAAARPGQSWNVLKMTCSFKSACTSLWQNGETRFSLVGTSLFWGAGVTLRFLLVLWVPVALGITDNATPTYLNAMVAIGIVLGAGAAAKLVTLETVSRCMPAGILIGVVVLFFSLQHELLPAYALLMLIGVLGGFFVVPLNALLQERGKKSVGAGNAIAVQNLGENSAMLLMLGIYSLAVLVGIPVVPIGIGFGTLFALAITALWIWQRRH

Catalyzes the facilitated diffusion of 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) into the cell.

B7LNJ1

Q6LG09

OTC_PHOPR

Ornithine carbamoyltransferase

Photobacterium

MSFNLRNRNFLKLLDFTGKEIEHLIALAQDLKHAKYAGTEQQKLKGKNIALIFEKTSTRTRCAFEVAAHDQGAHVTYIGGGSQMGHKESTKDTARVLGRFYDGIEYRGFGQDVVETLGEHAGVPVWNGLTDEWHPTQIIADWMTMLEHGNGKRLNQMKLAYMGDAKNNMGNSLMVGAAKVGMEIRLVGPKAYWPDPALVAECNELCKISGGKIVITDNVQEGVDSVDFIYGDVWVSMGEPEELWATRINDLAPYQVNMSVITATQNPAVKYMHCLPAFHNDETRVGKKIEEKFNMKGLEVTEDVFESSYTICFDEAENRMHSIKAIMVATLGD

Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.

Q6LG09

Q01345

NHEB_ONCMY

Na(+)/H(+) antiporter

Oncorhynchus

MPAFSCAFPGCRRDLLVIVLVVFVGIGLPIEASAPAYQSHGTEGSHLTNITNTKKAFPVLAVNYEHVRKPFEIALWILLALLMKLGFHLIPRLSAVVPESCLLIVVGLLVGGLIKVIGEEPPVLDSQLFFLCLLPPIILDAGYFLPIRPFTENVGTILVFAVIGTLWNAFFMGGLLYALCQIESVGLSGVDLLACLLFGSIVSAVDPVAVLAVFEEIHINELVHILVFGESLLNDAVTVVLYNLFEEFSKVGTVTVLDVFLGVVCFFVVSLGGVLVGAIYGFLAAFTSRFTSHTRVIEPLFVFLYSYMAYLSSEMFHLSGIMALIACGVVMRPYVEANISHKSYTTIKYFLKMWSSVSETLIFIFLGVSTVAGPHAWNWTFVITTVILCLVSRVLGVIGLTFIINKFRIVKLTKKDQFIVAYGGLRGAIAFSLGYLLSNSHQMRNLFLTAIITVIFFTVFVQGMTIRPLVELLAVKKKKESKPSINEEIHTEFLDHLLTGVEGVCGHYGHYHWKEKLNRFNKTYVKRWLIAGENFKEPELIAFYRKMELKQAIMMVESGQLPSVLPSTISMQNIQPRAIPRVSKKREEEIRRILRANLQNNKQKMRSRSYSRHTLFDADEEDNVSEVRLRKTKMEMERRVSVMERRMSHYLTVPANRESPRPGVRRVRFESDNQVFSADSFPTVHFEQPSPPSTPDAVSLEEEEEEVPKRPSLKADIEGPRGNASDNHQGELDYQRLARCLSDPGPNKDKEDDDPFMSC

Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient.

Q01345

Q54ME1

GMSA_DICDI

Gamete and mating-type specific protein A

Dictyostelium

MKLILVLLCLISTLFVVKGGLSPTEQQIIVSYHNKWRSSPIGPTPSTTIPALKWNATIAAALQSSLDKCDGKFSTMSQYGTNSEWQSWWTPNTYFNLNATLDNIQKGASFYDWNAKGCNSSANYNCQLWTYAVWSKSTSYGCAKTICPDKSEVSCSYYPAGGFKGVLPYTPKTTTPAPTTPAPTTPKPTTPAPTTPKPTTPAPTTPKPTTPAPTTPKPTTPAPTTPKPTTPAPTTPAPTSTLTVDWTSYQTPIRDQGQCGSCWAFASSAALESRYLIKYGTAQKSTLQLSNQNAVNCIASGCNGGWSGNYFNFFKTPGIAYEKDDPYKAVTGTSCITTSSVARFKYTNYGYTEKTKAALLAELKKGPVTIAVYVDSAFQNYKSGIYNSATKYTGINHLVLLVGYDQATDAYKIKNSWGSWWGESGYMRITASNDNLAIFAYNSYYPTF

Thiol protease that seems to be involved in the sexual development.

Q54ME1

Q8UIE8

SYW_AGRFC

Tryptophanyl-tRNA synthetase

Agrobacterium tumefaciens complex

MNAFKPLVFSGVQPTGNLHLGNYLGAIRKFVALQEDNDCIYCVVDMHAITAQLVHSDLKAQTRSIAAAFIAAGIDPVKHIVFNQSAVPQHAELAWVFNCVARIGWMERMTQFKDKSGKNAEQVSLGLLAYPSLMAADILVYRATHVPVGDDQKQHLELARDIAQKFNIDFGGHIRNAGLGVNITVGDEPVHAYFPMVEPLIGGPAPRVMSLKDGTKKMSKSDPSDLSRINLMDDVDAISKKIKKAKTDPDALPSEVEGLKGRPEAENLVGIYAALSDKTKADVLAEFGGQQFSTFKPALVELAVNVLAPVNNEMRRLLDDPTHIDAILSQGGERARTIAEKTMNEVRDIIGFLR

Catalyzes the attachment of tryptophan to tRNA(Trp).

Q8UIE8

A6UYL3

PYRR_PSEA7

Uracil phosphoribosyltransferase

Pseudomonas

MSLPNPAELLPRMASDLRAHLAERGIERPRYVGIHTGGIWVAEALLKALGNEEPLGTLDVSFYRDDFTRNGLHPQVRPSALPFEIDGQHLVLVDDVLMSGRTIRAALNELFDYGRPASVTLVCLLDLNARELPIRPDVVGQTLSLGRDERVKLVGPAPLALERKVLSPAS

Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.

A6UYL3

B7GFF3

RECR_ANOFW

Recombination protein RecR

Anoxybacillus

MYYPEPISKLIDSFMKLPGIGPKTAVRLAFFVLNMKEDVVLDFAKALVNAKRNLTYCSSCGHITDKDPCYICEDDKRDRSIICVVQDPKDVIAMEKMKEYNGLYHVLHGAISPMEGIGPEDIKIAELLRRLQDETVQEVILATNPNIEGEATAMYISRLLKPTGVKITRIAHGLPVGGDLEYADEVTLSKALEGRREL

May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

B7GFF3

O42807

FAEA_ASPNG

Ferulic acid esterase A

Aspergillus subgen. Circumdati

MKQFSAKYALILLATAGQALAASTQGISEDLYNRLVEMATISQAAYADLCNIPSTIIKGEKIYNAQTDINGWILRDDTSKEIITVFRGTGSDTNLQLDTNYTLTPFDTLPQCNDCEVHGGYYIGWISVQDQVESLVKQQASQYPDYALTVTGHSLGASMAALTAAQLSATYDNVRLYTFGEPRSGNQAFASYMNDAFQVSSPETTQYFRVTHSNDGIPNLPPADEGYAHGGVEYWSVDPYSAQNTFVCTGDEVQCCEAQGGQGVNDAHTTYFGMTSGACTW

Involved in degradation of plant cell walls. Hydrolyzes the feruloyl-arabinose ester bond in arabinoxylans, and the feruloyl-galactose ester bond in pectin. Binds to cellulose.

O42807

B1IA76

RIMP_STRPI

Ribosome maturation factor RimP

Streptococcus

MDAIATIVELVREVVEPVIEAPFELVDIEYGKIGSDMILSIFVDKPEGITLNDTADLTEIISPVLDTIKPDPFPEQYFLEITSPGLERPLKTKDAVAGAVGKYIHVGLYQAIDKQKVFEGTLLAFEEDELTMEYMDKTRKKTVRIPYSLVSKARLAVKL

Required for maturation of 30S ribosomal subunits.

B1IA76

P40283

H2B11_ARATH

HTB4

Arabidopsis

MAPKAEKKPAEKKPASEKPVEEKSKAEKAPAEKKPKAGKKLPKEAGAGGDKKKKMKKKSVETYKIYIFKVLKQVHPDIGISSKAMGIMNSFINDIFEKLAQEASKLARYNKKPTITSREIQTAVRLVLPGELAKHAVSEGTKAVTKFTSS

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

P40283

Q5L3D3

PURQ_GEOKA

Phosphoribosylformylglycinamidine synthase subunit I

Geobacillus thermoleovorans group

MKFAVVVFPGSNCDVDMYHAIADELGEEVEYVWHDEDNLDRFDAVLLPGGFSYGDYLRSGAIARFSKVMAAVKKAAEAGKPVLGVCNGFQILLEAGLLPGAMRRNQGLKFICRPVQLTVENHETMFTSAYEKGEVITIPIAHGEGNYYCDEQTLERLVENRQIVFRYHGENPNGSLADIAGIVNEQGNVLGMMPHPERAVDALLGSADGLKLFRSIVNYWRETHVVTA

Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

Q5L3D3

Q90WG1

SPINZ_CHICK

Spindlin-Z

Gallus

MKTPFGKSPGQRSRADAGHAGVSASMMKKRTSHKKHRNNVGPSKPISQPRRNIVGCRIQHGWKEGSGPVTQWKGTVLDQVPVNPSLYLIKYDGFDCVYGLELHKDERVSALEVLPDRVASSRISDAHLADTMIGKAVEHMFETEDGSKDEWRGMVLARAPIMNTWFYITYEKDPVLYMYQLLDDYKEGDLRIMPDSNDSPPAEREPGEVVDSLVGKQVEYAKEDGSKRTGMVIHQVEAKPSVYFIKFDDDFHIYVYDLVKTS

May play a role in mitosis.

Q90WG1

A4WVP0

PCKA_CERS5

Phosphoenolpyruvate carboxykinase (ATP)

Cereibacter

MNFGRVNPAQTLDAQGITGLGEVHYNLIEPALVEAAVKRGEGRLGRGGAFLCSTGAFTGRSPKDKFVVRTPSVEDTIWWENNAPMDPEAFDRLHADMLEHMKGRTYFVQDLFAGADPELRLDVRMVTELAWHGLFIRHMLRRPERTELDSFVPEWTVINCPSFKADPARHGCRTDTVITLNFDKKLILIANTEYAGENKKSVFTLLNYILPGKGVMAMHCSANHAIGNTDDAAVFFGLSGTGKTTLSADPSRTLIGDDEHGWSDKGTFNFEGGCYAKTINLSPEAEPEIYATTSKFATVVENMVYNEETLELDFDDDSLTANTRCAYPLEYISNASATGMGGHPKNVIMLTCDAFGVLPPIARLTPAQAMYHFLSGFTSKVAGTERGVTEPQPTFSTCFGAPFMPRRPEVYGKLLQEKITSLGATCWLVNTGWTGGAYGTGKRMPIKATRALLTAALDGSLANVTFRKDPNFGFEVPTELHGVDSSLLDPRSTWADPAAYDAQAKKLVEMFANNFAQYVPYIDADVKAAAIG

Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.

A4WVP0

Q9CY34

UB2FA_MOUSE

Ubiquitin-conjugating enzyme E2 F

Mus

MLTLASKLKRDDGLKGSRTSASTSDSTRRVSVRDKLLVKEVAELEANLPCTCKVHFPDPNKLHCFQLTVSPDEGYYQGGKFQFETEVPDAYNMVPPKVKCLTKIWHPNITETGEICLSLLREHSIDGTGWAPTRTLKDVVWGLNSLFTDLLNFDDPLNIEAAEHHLRDKEDFRDKVDEYIKRYAR

Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5.

Q9CY34

Q8EGW8

SSRP_SHEON

Small protein B

Shewanella

MVKKNSKKAAPATIARNKRATFEYRFEEKMEAGLSLMGWEVKSIRMGKVNLSDCYVFLKNGEAFMHGCTIIPLNTASTHVVCDPIRLKKLLLSRKELDKLAGLVERQGYSIIPISMYWRKGAWVKVEIGLGKGKKDHDKREDTKAREWEVEKARVMKKEKTRG

Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

Q8EGW8

Q5WH37

DEOB_ALKCK

Phosphodeoxyribomutase

Alkalihalobacillus

MKKRFERIFLIVMDSVGIGEAPDAKEFGDEGANTLGSIAEAFNGLHVPELEKLGLGKIAPLKGVKNVPTPLASYGIMQEASLGKDTMTGHWEIMGLHITKPFQVFPDGFPTELLEQLKSETGRGIIGNKVASGTEILDELGEEHVKTGDLIVYTSADSVLQIAAHEEVVPLEELYDICEKARKLTLAPEYMVGRVIARPFVGEPGKWKRTANRHDYALKPFGRTVMNTLEDAGLASIALGKISDIYDGEGVTKAVRTTSNEDGMDKLAEQINTSFEGLCFLNLVDFDALYGHRRDVIGYGEAIMAFDQRLGEILPQLGDEDLLIVTADHGNDPTHTGTDHTREYVPLLVYNKGIKPVNLGKRRTFADIGATVADNFQVERPSNGTSFLTELKPE

Phosphotransfer between the C1 and C5 carbon atoms of pentose.

Q5WH37

Q5QYV0

RUVC_IDILO

Holliday junction resolvase RuvC

Idiomarina

MAIILGIDPGSRLTGYGVIEQRGRQLNYLGSGCIKVIGTTKEPLTLAEKLRRIHDSVSELITQFKPNEFAIEQVFMAKNPDSALKLGQARGAAIVAAACAELPVAEYSARQIKQSVVGNGGAEKSQVQHMVMALLNLQRCPQEDAADALAVALCHAHSSQNLIKMAGAARKTVRGRLR

Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.

Q5QYV0

P0AE71

MAZF_ECO57

mRNA interferase MazF

Escherichia

MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG

Toxic component of a type II toxin-antitoxin (TA) system. MazF is a sequence-specific endoribonuclease that inhibits protein synthesis and induces bacterial stasis. It is very stable, single-strand specific and cleavage is independent of the ribosome. The endoribonuclease activity (a toxin) is inhibited by the labile cognate antitoxin MazE. Toxicity results when the levels of MazE decrease in the cell, leading to mRNA degradation. Both MazE and MazE-MazF bind to the promoter region of the mazE-mazF operon to inhibit their transcription.

P0AE71

A0A1W2PPG7

GBG14_HUMAN

Putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14

Homo

MSSKVAINSDIGQALWAVEQLQMEAGIDQVKMAADLLKFCTEQAKNDPFLVGIPAATNSFKEKKPYAIL

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

A0A1W2PPG7

Q8XXL5

ADE_RALSO

Adenine aminohydrolase

Ralstonia

MPISPALAERIATSPKAELHIHIEGSLEPELMFALAERNGVKLPYASVDEVRAAYAFNDLQSFLDLYYAGASVLLTEQDFYDMTAAYVARAVADNVRHAEIFFDPQTHTARDVPMHVVIGGIVRALDDAERAHGFSSRLILCFLRHLSEADAFDTLEAALPYIQDPANRIIGVGLDSSERGNPPEKFARVFARCKALGLRLVAHAGEEGPAQYVIDALDILQVERIDHGVRAIDDAALVKRLAASRVALTVCPLSNEKLKVYPDLRDHSLKQLLDAGCAVTLHSDDPAYFGGYMNTNWLATFNALGLSAADAHTLARNSFEASFLPEQDKALWLNAVDIHWRAHT

Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.

Q8XXL5

A7ZSM0

TUSD_ECO24

tRNA 2-thiouridine synthesizing protein D

Escherichia

MRFAIVVTGPAYGTQQASSAFQFAQALIVEGHELSSVFFYREGVYNANQLTSPASDEFDLVRGWQQLNAQHGVALNICVAAALRRGIVDETEAGRLGLASSNLQPGFTLSGLGALAEASLTCDRVVQF

Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE.

A7ZSM0

B4S433

DER_PROA2

GTP-binding protein EngA

Prosthecochloris

MKPLVALVGRPNVGKSTLFNRITHQKSAIVDSTPGVTRDRHIMPAEWIGKEFLVMDTGGYCHDSDGISKAMLEQTLTAIGEADVIIFLVDVRSGLTYLDLDMAKLLKRDFNDKPVYFAVNKVESPQLAYEGESFRKTGFTEPWFISARDGSGVADLLDAVVDSFEEKSGQEEEDDSIRLAIIGRPNVGKSSFVNALLGTNRNIVSNKPGTTRDAIDTRFKRNGREIVLIDTAGLRKRARIDAGIEFYSSLRTERAIERCDVALVLIDAEQGLEKQDMKIIEMAAERKKGVLLLVNKWDLIEKDSKTSKLYSDRMYDDMGNLGWIPIQFISAMTKKNLYRAIDAALDIQEQRSQQITTSDLNRFLQDTLLQAPPSSKSGKELKIKYMTQIRAPWPVFAFFCNDPKLLQNNYKRFLEKRIRQNYNLSGVPFSLRFMQK

GTPase that plays an essential role in the late steps of ribosome biogenesis.

B4S433

J7FK10

IDTM_CLAPA

Indole-diterpene biosynthesis cluster protein M

Claviceps

MADDFKVVIVGGSVAGLSLAHCLERLGVSYVVLEKGSQIAPQLGASIGILPNGGRILDQLGIFRDVEDEIEPLNFAVIRYADGFSFRSQYPKALHSSYGYPVSFLERQKFIQILYDKLRGKNHVHTRKRVVSIVDGPGKALIRTDDGDEYDADMVVGADGVHSVVRSEIWRHAKEAAGTAVTEEEPNADIKYDYACVYGISVNVPHADTGVQLSSLSDGVSIHLFAGKGSKFFWFIMVRTSRDEFLELKKDSAHMARRTCEGLGSKRLSDAVYFRDVWSRCTVYQMTPLEEGVFRQWNRGRLVCIGDAIRKMAPNIGQGANMAIEDAAQLSNLIREMLASPRKASATTVEKMLRDFAAMQKARTKSMCGQSEFLVRMHANEGFGRRLLGRYLIPSLQDAPAGLAGLSIRGAVKLECAGVPSRTLGKAWEGSWGSSLRNLMYLRPRLGILSLVYVVAGLAMMYMSIYLVVPARLAAQAFDVSRDGTEGKGGG

FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of paspalitrems, indole-diterpene (IDT) mycotoxins that are potent tremorgens in mammals . The geranylgeranyl diphosphate (GGPP) synthase idtG is proposed to catalyze the first step in IDT biosynthesis via catalysis of a series of iterative condensations of isopentenyl diphosphate (IPP) with dimethylallyl diphosphate (DMAPP), geranyl diphosphate (GPP), and farnesyl diphosphate (FPP), to form GGPP (Probable). Condensation of indole-3-glycerol phosphate with GGPP by the prenyltransferase idtC then forms 3-geranylgeranylindole (3-GGI) (Probable). Epoxidation of the two terminal alkenes of the geranylgeranyl moiety by the FAD-dependent monooxygenase idtM, and cyclization by the terpene cyclase idtB then leads to the production of paspaline (Probable). The cytochrome P450 monooxygenase idtP then catalyzes oxidative elimination of the pendant methyl group at C-12 of paspaline and generates the C-10 ketone to yield 13-desoxypaxilline . The cytochrome P450 monooxygenase idtQ may catalyze the C-13 oxidation of 13-desoxypaxilline to afford paxilline (Probable). Considering that both paspalicine and paxilline were detected in C.paspali, idtQ also catalyzes the formation of paspalinine from 13-desoxypaxilline via paspalicine as an intermediate (Probable). Finally, the alpha-prenyltransferase idtF prenylates paspalinine at the C-20 or the C-21 positions to yield paspalitrems A and C, respectively . The hydroxylation of paspalitrem A at C-32 by a still unknown oxidase affords paspalitrem B (Probable).

J7FK10

Q98LX2

GLMU_RHILO

Glucosamine-1-phosphate N-acetyltransferase

Mesorhizobium

MSQRSCLSVILAAGEGTRMKSALPKVLHQIAGLPMVAHVVKAADAAGASSDAIVIGHGAEEMRKAVTKFSPKAETFVQEERLGTAHAVLAAREAISRGYDDILVMFGDTPLIDAEALNLARLKLAEGAAVAVIGFRPPLPNGYGRLVEKGGKLIAIREEKDCSEAEKKIGFCNAGMMAVAGAHALKLLDAVGNKNAKGEYYLTDIVEIAGAQGLDVVATEASFENALGINNRAELAQAEGIWQARRRQEAMLSGVTLIAPETVYFSHDTEIGADTVVEPNVWFGPGVKIAGGAKIHAFSHIEGATIAANCDVGPFARLRPGADLRNKAKVGNFCEVKQAVIEEGAKVNHLTYIGDARVGAGANIGAGTITCNYDGFSKFFTDIGEGAFVGSNSSLVAPVSIGKGGYIASGSVITESVPDDALAFGRARQKTIPGKGKELRERFASAAAAKKKAAGADH

Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.

Q98LX2

B1ZND9

RS17_OPITP

30S ribosomal protein S17

Opitutus

MSSSPAQRHTRKTQIGFVSSRSGDKSIKVTVPYKSPHPLYHKIVNRQTVLHVHDEKNEAKLGDTVEVMETRPMSRLKRWRIVSIVQRAVTTDAVAISETDVAAQVPTKTTASNTPAPAEQPAPQA

One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.

B1ZND9

B0TUD3

TRMN6_SHEHH

tRNA m6A37 methyltransferase

Shewanella

MPFTFKLFHVDDSRCGMPVSTDGVLLGAWAPLVQAKTILDIGAGSGLLSLMAAQRSQAKITAIELDNDAALDCQQNFDASHWSERLEIICCDIQAYCQREQARQFDHIICNPPYFANGPQSSKFSRATARHTDSLSFDALLQAIKQLLAPEGQASLILPTESVSLLEAILSTYNLRLCHKLLAASVEGKAPNRQILVLGHDLKAKKIHNFGTELQAVAQQQLYIREKTGHYSLAFTLLSQDFYLKL

Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).

B0TUD3

Q8UVQ4

KAISO_XENLA

Zinc finger and BTB domain-containing protein 33

Xenopus

METKKLITATDTQYSGILLNALNDQRIQGLYCDVTVIVEDRKFRAHRNILSACSTYFHQLFSVAGQVVELNFVKADIFAEILNYIYSSKIVRVRCDMLEELIKSGKLLGVPFIAELGIPLSQVKSISGAGGKDGGTDAPSNPDHKAPEPQKSSDSPLPCTVKIKADVKTEMPVITESFSLSSDDYKDKKASGSQDHNSEKEDDDDDVIFCSEIVSSKQAPAERKEAAQTQIPPDNEQVPEVKKVTPSSQVQLTQNSLPTNQQSSKNTSSTTQKFTPPVNANISKNPTPAANGFLSPTAQKQGTPNAVQNQHSQNITSGNALPQQKPVVNFSSIKPQQISAIKPKTEVIIHGNGLSPPSSSVIPLGQQPVTPKHISFDGVQKKQVVTFTQGSPSKPGEFKIKIADVVSGSSLDSFKDSEPRRIIDGKKIITLDTASEIEGLSTGCKVYANIGEDTYDIVIPIKEDPEEGEAKLDLDGLPNRKRMKLKHDDHYELIVDGRVYYICIVCKRSYVCLTSLRRHFNVHSWEKKYPCRYCERVFPLAEYRTKHEIHHTGERRYQCLTCGSSFINYQVMASHIRSVHSLDPSGDSKLYRLNPCKTLQIRQYAYVNNSTNGTVINDGAINVPVITDGGINVPVINDGGIVYDIDPDEPQQPASEGNHANSATKPVNWDNIFIQQSNQNMFKLNTSEGGTEFEFVIPESY

Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3'. May recruit the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. Contributes to the repression of target genes of the Wnt signaling pathway and to the methylation-dependent repression of zygotic transcription prior to the mid-blastula transition (MBT). Also required for gastrulation movements.

Q8UVQ4

B0BAF4

PSD_CHLTB

Phosphatidylserine decarboxylase beta chain

Chlamydia

MAAREMLYVNRETGKVEQERIICSSLVKFFIETRIGRALYSVLCKNSLFSRIVGWCQRLRVTRYFIKPFVTKYRICIEESASPLHDYASFNDFFVRKLKPDARPICQGEDICVTPADGAYLVFPSMADLSLFTIKNKPFSLESFLGDPQLAHQYAQGSMAIARLAPFDYHRFHFPIAGIAEAPRRINGHLFSIHPLMLKRNFEVFTENKREITIITSKEFGEVAYVEVGALNVGSIHQTFSPGSYVKKGAEKGFFAFGGSTVVLLFQPQRIIFDADLVGYSAQGLETRCRMGQSLGKHFSS

Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).

B0BAF4

Q8Y4B6

ATP6_LISMO

F-ATPase subunit 6

Listeria

MEEEFPTISLLGIDFNLSNILMITVTCVIVLLIAIICTRNLQRRPTGKQNFIEWVMDFVRGIINSNMDWKTGGRFHVLGITILMFVFVANMLGLPLQIAVNDEVWWRSPTADPIVTLTLAIMVLGLTHYYGIKMRGFKHYFVGTYLSPMKFLFPLKLVEEFANTLTLGLRLYGNIFAGEVLLTIIATQLAHINIFVGVLAIIPAIIWQAFSLFIGAIQAYIFTMLTMVYMSHKVSDEH

Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.

Q8Y4B6

A2DZE8

ALG5A_TRIVA

Dolichyl-phosphate beta-glucosyltransferase ALG5A

Trichomonas

MKFWRFVQILFFLGVAAVGLVVAVMIANADDTTLFDRMQLPDGDPNKLNYYIQPAPNGNEKVPFPTIFDPASVYLSLVVPAYNEEKRLPKMLDETLNYLKSREEKDKSFTWEIVIVNDGSKDKTKEVVLNYAKEYPNIFLLNQPVNMGKGAAIQAGCLHVRGELVLMLDADGATKIDDFEVLEKEIKSLMKTTNQAIVIGSRAQNEKAKRTPLRKFLSIGMHTLIVLSGVHGIRDTQCGFKLFTRESCKMIFMNQHVQRWCCDPEILVIARRLGMKISELPVEWNEIDGSKMKISGMIKMATDLIKIAIFHRVGAWKIRDRRH

Dolichyl-phosphate beta-glucosyltransferase involved in the glycosylation of glycoproteins through the synthesis of dolichyl beta-D-glucosyl phosphate which serves as a sugar donor for transfer of three glucose residues to the Man-9-GlcNAc-2-PP-dolichol precursor to N-glycans.

A2DZE8

O46392

CO1A2_CANLF

Alpha-2 type I collagen

Canis

MLSFVDTRTLLLLAVTSCLATCQSLQEATARKGPTGDRGPRGERGPPGPPGRDGDDGIPGPPGPPGPPGPPGLGGNFAAQYDGKGVGLGPGPMGLMGPRGPPGASGAPGPQGFQGPAGEPGEPGQTGPAGARGPPGPPGKAGEDGHPGKPGRPGERGVVGPQGARGFPGTPGLPGFKGIRGHNGLDGLKGQPGAPGVKGEPGAPGENGTPGQTGARGLPGERGRVGAPGPAGARGSDGSVGPVGPAGPIGSAGPPGFPGAPGPKGEIGPVGNPGPAGPAGPRGEVGLPGVSGPVGPPGNPGANGLTGAKGAAGLPGVAGAPGLPGPRGIPGPVGAAGATGARGIVGEPGPAGSKGESGNKGEPGSAGAQGPPGPSGEEGKRGPNGEAGSAGPSGPPGLRGSPGSRGLPGADGPAGVMGPPGPRGATGPAGVRGPNGDSGRPGEPGLMGPRGFPGAPGNVGPAGKEGPMGLPGIDGRPGPIGPAGARGEPGNIGFPGPKGPTGDPGKNGDKGHAGLAGARGAPGPDGNNGAQGPPGPQGVQGGKGEQGPAGPPGFQGLPGPAGTAGEVGKPGERGLPGEFGLPGPAGPRGERGPPGESGAAGPSGPIGSRGPSGPPGPDGNKGEPGVLGAPGTAGASGPGGLPGERGAAGIPGGKGEKGETGLRGEIGNPGRDGARGAPGAMGAPGPAGATGDRGEAGPAGPAGPAGPRGTPGERGEVGPAGPNGFAGPAGAAGQPGAKGERGTKGPKGENGPVGPTGPIGSAGPSGPNGPPGPAGSRGDGGPPGATGFPGAAGRTGPPGPSGITGPPGPPGAAGKEGLRGPRGDQGPVGRTGETGASGPPGFTGEKGPSGEPGTAGPPGTPGPQGLLGAPGILGLPGSRGERGLPGVAGSVGEPGPLGIAGPPGARGPPGAVGAPGVNGAPGEAGRDGNPGNDGPPGRDGQAGHKGERGYPGNIGPVGAVGAPGPHGPVGPTGKHGNRGEPGPAGSVGPVGAVGPRGPSGPQGIRGDKGEPGEKGPRGLPGLKGHNGLQGLPGLAGQHGDQGAPGSVGPAGPRGPAGPSGPAGKDGRTGQPGTVGPAGIRGSQGSQGPAGPPGPPGPPGPPGPSGGGYDFGYEGDFYRADQPRSPPSLRPKDYEVDATLKSLNNQIETLLTPEGSRKNPARTCRDLRLSHPEWSSGYYWIDPNQGCTMDAIKVYCDFSTGETCIRAQPENIPAKNWYRNSKVKKHIWLGETINGGTQFEYNVEGVTTKEMATQLAFMRLLANHASQNITYHCKNSIAYMDEETGNLKKAVILQGSNDVELVAEGNSRFTYTVLVDGCSKKTNEWRKTIIEYKTNKPSRLPILDIAPLDIGDADQEFRVDVGPVCFK

Type I collagen is a member of group I collagen (fibrillar forming collagen).

O46392

C5CFW2

MURA_KOSOT

UDP-N-acetylglucosamine enolpyruvyl transferase

Kosmotoga

MSEIVVEGGRKLIGEVPISGSKNAALPILAAAVMIDEPVVLDNVPELKDVFTMLTILQRIGKKVSFRDNRVVVEPGNVLMGDVPYELVRMMRASFNVLGPLTMVCGWAKVGKPGGCNIGQRPVDFHIEGLKALGFLIKEEHGDVIAKKPSSFKEELYYKLPFPSVGATEQLMTVAALMSESKTIIENVAREPEIQDLQNFLNKAGAKIKGAGTDRIEIEGVEKLHGIEYHIIPDRIEAGTYLLAGVSTRGRVKVSNVIPEHLEALLKVLDELGVSITCDKNSIEVSVSGELKPIRVSTAPYPGFPTDLQPMLTAVLCTVPGESIIEEKVFENRFGYVDEMNRMSANIKVMNRVAHIVGVEKLSGAQIYAPDIRATAGMLIAALSAEGQTVIKNAAHIFRGYEKLKEKFTTIGAQIEVYPEE

Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.

C5CFW2

Q31G53

FABZ_HYDCU

Beta-hydroxyacyl-ACP dehydratase

Hydrogenovibrio

MLNVKEIFEYLPHRYPFLLVDRVTEFKSGESLKAYKNVTYNEPQFTGHFPDNPIMPGVMIIEAMAQCTGILAFKTQDVKPDGTSMYYLAAVDNCRFRKPAIPGDKLEFEVKTVNNKKGIWKFECTTSVDGKLIASCDMLCAERKV

Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

Q31G53

B9ME46

PTH_ACIET

Peptidyl-tRNA hydrolase

Diaphorobacter

MIKLFVGLGNPGPEYEATRHNAGFWWIDALARELKVTLVPERSYHGLVARASVAGHSVWLLQPQTFMNLSGKSVAALARFFKIPPEEILVAHDELDIPPGQAKLKRGGSHAGHNGLRDIHAQLGTSDYWRLRIGIGHPGVKAEVVNWVLKKPAPDQRTLIEDSILHSLKAYPALLAGDMDKATLLVHTTKPPRPKATRPAQAQAAPQAGAD

The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

B9ME46

B0BR79

FTSP_ACTPJ

Cell division protein FtsP

Actinobacillus

MMNLTRRQLLTRSAVAATMFSAPKTLWAAERQPLKIPPIIDVGRGRPVRLDLRPAQTQFDKGKLVDVWGVNGQYLAPTVRVKSDDFVKLTYVNNLPQTVTMNIQGLLAPTDMIGSIHRKLEAKSSWSPIISIHQPACTCWYHADTMLNSAFQIYRGLAGMWIIEDEQSKKANLPNKYGVNDIPLILQDQQLNKQGVQVLDANQKQFFGKRLFVNGQESAYHQVARGWVRLRIVNASLSRPYQLRLDNDQPLHLIATGVGMLAEPVPLESITLAPSERVEVLVELNEGKTVSLISGQKRDIFYQAKNLFSDDNELTDNVILELRPEGMAAVFSNKPSLPPFATEDFQLKIAEERRLIIRPFDRLINQKRFDPKRIDFNVKQGNVERWYITSDEAVGFTLQGAKFLIETRNRQRLPHKQPAWHDTVWLEKNQEVTLLVRFDHQASAQLPFTFGVSDFMLRDRGAMGQFIVTE

Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress.

B0BR79

A2RJS5

RIMM_LACLM

Ribosome maturation factor RimM

Lactococcus cremoris subsp. cremoris

MENFYKVGTIVNTQGLQGEVRILPSTDFANERFSKGAVLALFDDKDNYIQDLKVKSGRLQKNFYVVKFEGFYHINDVEKYKGYVVKIAQENQEELNDGEFYYHEIIGSDVYDNDILIGQISEILQPGANDVWVVKRKGKRDLLLPYIPPVVLKVDVAQHRVDVDIMEGLDD

An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.

A2RJS5

B3QBR5

GLNE_RHOPT

Adenylyl transferase

Rhodopseudomonas

MIFSAITADLDNTALAARFGAGPRLYDPVLAAERWAGWLVDLAPEQADAIAALGNAFPDLQIALQSIAEASPYLFDLIRGDPVRLLRVLRGAPEQRLAKLLEDAETFVAAASAEDEVMAALRRLKAEAALLIALCDIGGIWPVMQVTQALTDLAGRSVQMALRFLLRLEAGRGRIVPPNPDCPEQGSGLIVLAMGKMGAGELNYSSDIDLIVFYELDAPTLAPDIEPQPFFVRVTQGLSRILQQRRGDGYVFRVDLRLRPDPASTPVALSTVSALDYYEREGRTWERAAMIKARPCAGDLVAGDALLSEIAPFVWRKHLDFAALSDVHDMKRQMQTYRGQTEIAVEGHNVKVGRGGIREIEFFAQTQQLIAGGRHPELRVRPTLEALEILAARNWITIQARDELTEAYLFLRKVEHRVQMIADEQTHALPDTVEAIERFSRFLGYDSRDSFARDLLGYLERVQGHYAKLFEGDPTGTAKLPPVDYGAGPEDTRLLDHLLSLGYKKPLMIATTLQQWMTGGYRVLKVETTQRAFREFVPALIEELARAEQPDDAVNAFDRLLQALHRGGRLISLLSQNRELLTLVALVLGAAPRLGDMLARQPQILDGLIDPRFFGAMPDQAELSARLAVTLADAGSYEEFLDRLRLFGQESLFLIGTRILSGTVPTQQAAVAFADVAEGIVGTVHGLVSEQFASTYGRVKGQQTAILAMGKLGSREMTASSDLDLILIYDFDDDQPDSDGERSLHGAQYFARFTQRLISAFTTRTNYGVLYDVDMRLRPSGRAGPVASRLDAFAAYQEQEAWTWEHLALTRARVISAPPEFRSRIEQVIRAVLTRPRDAAIIANDVAEMRRAIAQEKGEDDVWDLKYAAGGMVDIDFIAQYLQLVHAHEAPDILHVNTLSALDNATRLGLLAQADAEVLRPAARLYQNLTQILRLCVSEKFNPDTAGDDLLRVMVRAGDAPDFSSLQARVKETQSDVRAIFNRLIGGEDA

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

B3QBR5

Q0UK52

STHC_PHANO

Stemphyloxin II biosynthesis cluster protein C

Parastagonospora

MAPAETTGNVQRPEAGKQSMGSFWTQMFPPKPTYTEEQVPDLTGKIFIVTGSSSGVGKEAARMLYAKNAKVYMAARPGPKLPAAINSVQEAVPKSGGALIPLELDLADLAVVKKAVEKFTSLETKLHGLINNAAVQALKDTDGDARTAQGHEIHMGVNVLAPFLFTRLLTGVLTATARQEPPGTVRVVWVSSMGTETIGEKRRGLSPDYVDYWPLMSPLERYGLSKAGNWLHGVEFARRYAADGIASFPINPGHLKSDLYREGGALFKFALKPVLYPPTYGAYVELFAALSPTLTLKDSGAWSKYVEMVYFPDC

Short-chain dehydrogenase/reductase; part of the gene cluster that mediates the biosynthesis of the phytotoxin stemphyloxin II . The first step of the pathway is the synthesis of dehydroprobetaenone I by the polyketide synthase sthA and the enoyl reductase sthE via condensation of one acetyl-CoA starter unit with 7 malonyl-CoA units and 5 methylations . The C-terminal reductase (R) domain of sthA catalyzes the reductive release of the polyketide chain . Because sthA lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase sthE . The short-chain dehydrogenase/reductase sthC then catalyzes reduction of dehydroprobetaenone I to probetaenone I . The cytochrome P450 monooxygenase sthF catalyzes successive epoxidation, oxidation (resulting from epoxide opening) and hydroxylation to install a tertiary alcohol in the decaline ring to yield betaenone C from dehydroprobetaenone I and betaenone B from probetaenone I . The FAD-linked oxidoreductase sthB is responsible for the conversion of betaenone C to betaenone A via an intramolecular aldol reaction between C-1 and C-17 to form the bridged tricyclic system in betaenone A . Finally, the cytochrome P450 monooxygenase sthD catalyzes the hydroxylation of C-15 to afford the final metabolite stemphyloxin II .

Q0UK52

P00457

NIFH1_NOSS1

Nitrogenase reductase

Nostoc

MTDENIRQIAFYGKGGIGKSTTSQNTLAAMAEMGQRIMIVGCDPKADSTRLMLHSKAQTTVLHLAAERGAVEDLELHEVMLTGFRGVKCVESGGPEPGVGCAGRGIITAINFLEENGAYQDLDFVSYDVLGDVVCGGFAMPIREGKAQEIYIVTSGEMMAMYAANNIARGILKYAHSGGVRLGGLICNSRKVDREDELIMNLAERLNTQMIHFVPRDNIVQHAELRRMTVNEYAPDSNQGQEYRALAKKIINNDKLTIPTPMEMDELEALLIEYGLLDDDTKHSEIIGKPAEATK

The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.

P00457

B7IE21

PANC_THEAB

Pantoate-activating enzyme

Thermosipho

MKVIEKIEEMKKISREILESKKAIGFVPTMGFLHEGHLSLVKAAKSENDITVVSIFVNPTQFGPNEDYNNYPRDLERDLSMLKDMEVDYVFVPSVEEMYPDSFSTYVEEIKLSRFLCGASRPGHFRGVCTVVTKLFNIVKPTRAYFGQKDAQQFRVLRRMVRDLNMDVELVEMPIVREPDGLALSSRNTYLNDEERKEAVRLYKSLLKAKELIESGEKDVEIIKNEMKKILTHPLLRIDYIEIVDEENLEPVEKIDRRVIIAIAVFVGRARLIDNMII

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.

B7IE21

Q9NX24

NHP2_HUMAN

snoRNP protein NHP2

Homo

MTKIKADPDGPEAQAEACSGERTYQELLVNQNPIAQPLASRRLTRKLYKCIKKAVKQKQIRRGVKEVQKFVNKGEKGIMVLAGDTLPIEVYCHLPVMCEDRNLPYVYIPSKTDLGAAAGSKRPTCVIMVKPHEEYQEAYDECLEEVQSLPLPL

Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.

Q9NX24

B8GT00

MINE_THISH

Cell division topological specificity factor

Thioalkalivibrio

MNFFNYFRSQKKKSAQVAKERLQVIVARERVHRDGPDYLPRLQEEILNVIRKYVQVDEDAVSIQLERDGDCEVLELNVTLPEHKA

Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.

B8GT00

Q6A1G2

FUT11_XENTR

Galactoside 3-L-fucosyltransferase 11

Silurana

MSAGCTQLVWGGRLHWGASHLLSCLLALCALWVLAAAEPTEGGSANVQGVGEAALYQGRGQHRVPSEDNVAVLSDQWEPSSFQPSSAFSGTDLGTMVADSYRGPGNSDRRSNKELPILLWWSENLFPHFPGDAERIDCPLSSCMVTKNKSVKLHKRTKSIIFYGTDFRAYEAPLPRLPHQTWALFHEESPMNNYVLSHLPGIRLFNYTATFSRESDYPLTLQWLPTIGYLHNPALSMAEKNRWRKNGYAPVLYMQSHCDVPSDRDRYVKELMKHLEIDSYGQCMKNREHPNKRLEDTSTATTEDPEFMAFTARYKFHLAMENAICADYMTEKLWRPMHLGAIPIYRGSPSVRDWMPNNHSIIMIDDFASPKELAEFIMTLDSDDEQYLKYLEYKKPGGTTNTFLLSSMEKREWGVNDMTAPNYLNGFECFVCDKENSRIKAEKTYKKSQQGGAAPEPHIADFNHMGCPMPTPGFGSAQEIPESDSWKQMWLQDYWQSFDQGEALTAMIQRNETNQDRFWDYMHETYIKRSMNH

Probable fucosyltransferase.

Q6A1G2

Q9CG33

SCPA_LACLA

Segregation and condensation protein A

Lactococcus

MIKEINIKIKNFEGPLDLLLHLVSQYEMDIFEVPLVPVIEQYLIYIQTMKELELEVAGEYMLMASQLMLIKSRRLLPTVTETFIEDTEQLEYDLLAQIDEYRKYKMLSQDLDELHQERSHFYSKAKTEIITDETVLLQDKSALDLFLAFTKILELQRQHFQDENTKIAAEKFTIADKILELSTRFTEQKICKFSDLFSSSTNKDELVTTFMALLELIKNQQISFSQGELFGEIILERKETSE

Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.

Q9CG33

Q2JFF1

RS13_FRACC

30S ribosomal protein S13

Frankia

MARLSGVDLPREKRVEIALTYIFGIGRSRSRDTLAATAVNPDTRVRDLSEEEIVRLRDWIDANYRVEGDLNREIKQDIRRKMEIGCYQGLRHRRNLPVHGQRTHTNARTRKGPRRAIAGKKKAGKK

Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.

Q2JFF1

B2HUM8

HEM1_ACIBC

Glutamyl-tRNA reductase

Acinetobacter calcoaceticus/baumannii complex

MSFFALGVNHQTASVELREQIAFNAERLSNLLAEQRHHESLKDLVVVSTCNRTEVYAMAEDAESLLKWLADANNIDVKQLIHHVYRYENAQAITHLMRVASGLDSLMLGEPQILGQVKSALALSKEAQTVSPELNSVFEYAFYAAKRVRSETAVGSHAVSMGYAVAQLALQVFSKPEKLTVMVVAAGEMNSLVAKHLAEMGVAKMIICNRSRERADQLAQEIAHQVEVEIIDFSDLAENLYRADVVSSCTGSLHQVIAYADVKTALKKRRYQQMLMVDLAVPRDIDPKVESLDGVYLYGVDDLQSVIDENLAQRRQAAVEAEVMVNQLATQLITHQKVKEAGSTIHAYRQHSEEISQRELTQALEALHHGGNPEQVLQQFAHRLTQKLIHPTSMLLREAAKAESPDYFEWLQQHLQDVFDHERKPKR

Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).

B2HUM8

O94811

TPPP_HUMAN

p25-alpha

Homo

MADKAKPAKAANRTPPKSPGDPSKDRAAKRLSLESEGAGEGAAASPELSALEEAFRRFAVHGDARATGREMHGKNWSKLCKDCQVIDGRNVTVTDVDIVFSKIKGKSCRTITFEQFQEALEELAKKRFKDKSSEEAVREVHRLIEGKAPIISGVTKAISSPTVSRLTDTTKFTGSHKERFDPSGKGKGKAGRVDLVDESGYVSGYKHAGTYDQKVQGGK

Regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath . Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, and promotes microtubule nucleation, an important step for elongation of the myelin sheath . Required for both uniform polarized growth of distal microtubules as well as directing the branching of proximal processes . Shows magnesium-dependent GTPase activity; the role of the GTPase activity is unclear . In addition to microtubule nucleation activity, also involved in microtubule bundling and stabilization of existing microtubules, thereby maintaining the integrity of the microtubule network . Regulates microtubule dynamics by promoting tubulin acetylation: acts by inhibiting the tubulin deacetylase activity of HDAC6 . Also regulates cell migration: phosphorylation by ROCK1 inhibits interaction with HDAC6, resulting in decreased acetylation of tubulin and increased cell motility . Plays a role in cell proliferation by regulating the G1/S-phase transition . Involved in astral microtubule organization and mitotic spindle orientation during early stage of mitosis; this process is regulated by phosphorylation by LIMK2 .

O94811

P25033

HEMO_HYACE

Protein P4

Hyalophora

MAFKSIAVLSACIIVGSALPVDKYPVLKDQPAEVLFRENNPTVLECIIEGNDQGVKYSWKKDGKSYNWQEHNAALRKDEGSLVFLRPQASDEGHYQCFAETPAGVASSRVISFRKTYLIASPAKTHEKTPIEGRPFQLDCVLPNAYPKPLITWKKRLSGADPNADVTDFDRRITAGPDGNLYFTIVTKEDVSDIYKYVCTAKNAAVDEEVVLVEYEIKGVTKDNSGYKGEPVPQYVSKDMMAKAGDVTMIYCMYGSNPMGYPNYFKNGKDVNGNPEDRITRHNRTSGKRLLFKTTLPEDEGVYTCEVDNGVGKPQKHSLKLTVVSAPKYEQKPEKVIVVKQGQDVTIPCKVTGLPAPNVVWSHNAKPLSGGRATVTDSGLVIKGVKNGDKGYYGCRATNEHGDKYFETLVQVN

Insect-immune protein. Forms a protein complex at the bacterial surface. Can inhibit hemocyte aggregation.

P25033

B2GDT7

RL13_LIMF3

50S ribosomal protein L13

Limosilactobacillus

MRTTYMAKPGQVDRKWYVVDAKGISLGRLASTVASILRGKNKPTFTPHVDTGDYVIVINAAEVKLTGKKATGKIYYRHSNHPGGLKQRTAGDFLAKDPEKMVEQTIKGMLPHTSLGRKMGMKLHVYAGESHNQAAQKPEVLDITNLI

This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

B2GDT7

Q62K72

NODI_BURMA

Nodulation ATP-binding protein I

pseudomallei group

MSVAPIDFQQVEKRYDDKLVVDGLSFHVQPGECFGLLGPNGAGKTTTLKMLLGITHPDAGSISLCGEPVPSRARHARQRVGVVPQFDNLDPDFTVRENLLVFARYFGLTAHAARALVPPLLEFAKLESKADAKVGELSGGMKRRLTLARALVNDPDVLVLDEPTTGLDPQARHLMWERLRSLLARGKTILLTTHFMEEAERLCHRLCVIEEGRKIAEGAPRMLIEAEIGCDVIEIYGPDPVQLRDELAPFAERTEISGETLFCYVDNPEPIHARLKGRAGLRYLHRPANLEDVFLRLTGREMLD

Part of the ABC transporter complex NodIJ involved in the export of the nodulation factors (Nod factors), the bacterial signal molecules that induce symbiosis and subsequent nodulation induction. Nod factors are LCO (lipo-chitin oligosaccharide), a modified beta-1,4-linked N-acetylglucosamine oligosaccharide. This subunit is responsible for energy coupling to the transport system.

Q62K72

Q9I7M2

GTPBA_DROME

GTP-binding protein 10 homolog

Sophophora

MVQIFKFLLKSSKSTGRAHFRPTFLDTLRLAVRGGHGGNGLPKYGGVGGQGGCVYLVAKEGLTLRKVVQGLKDKRVAASSGEDSSKASIFGRRGADQRIEVPVGVQVYDDQQKLIADLDEHEATCIVAGGGTGGCTATNFLGRPGENRTVNLDLKLIADVGLVGFPNAGKSTLLKAVSNAKPKIAAYPFTTIRPQIGTIEYRDLRSITVADLPGLIEGAHANFGMGHKFLKHIERTRLLVFMVDIFGFQLSPKHPHRDCLANVYALNKELELYDPSLLEKPSVLLLNKMDKEGAHEIFTKVKPLVSDLASGLEQCPEELRPKQVLNFDSIVPISAMNSSKITQVKSQLRRTLVRLAEKQFLADEDQVKEKLRQRVGVVGPKIT

May be involved in the ribosome maturation process.

Q9I7M2

Q15NG5

DAPF_PSEA6

PLP-independent amino acid racemase

Pseudoalteromonas

MQVQFSKMHGLGNDFVVIDNVTQNVFFSKEKISQLADRNFGIGFDQLLVVEPPYDPEQDFHYRIFNSDGSEVSQCGNGARCFARFVKMKGLTNRNKIVVSTKAGRIVLYHERDGQITVNMGEPIFEPAKIPLKANKQENIYIIRENDHTFFCGAVSMGNPHCVLLVDDVETADVEGIGKTLVAHERFPEGANIGFMQILNSGHIKLRVYERGVGETLACGSGACAAVAVGQMQKKLNKEVTVDLPGGTLKIRWQGPGSILKMTGTAEHVFDGNITL

Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.

Q15NG5

A7H026

FMT_CAMC5

Methionyl-tRNA formyltransferase

Campylobacter

MNIIFMGTPAYARTILDALVRAGIGVAGVFTQPDKPVGRKQILTPSEVKIYAQQNLPHAKIFQPKTLKEGTVAAEILALKPDFIVVAAYGKILPKSVLDIAPCINLHASILPKYRGASPIQAALLNGEKNTGVTAMLMDEGLDTGDMLGFTHVSCEGKRSAEMFEILGELAGELAVKTLFDFKNLTPQKQDDALATHCKKIQKSDGLVNLSEDAEQIYNKFRAFHEWPGVFLESGLKFLELNLAEGSGAAGEILRIEKDGFVVACGTGALKILALQEAGKKALDAKAYINGKRLVAGNKIS

Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.

A7H026

C4L176

HIS6_EXISA

ImGP synthase subunit HisF

unclassified Exiguobacterium

MLKRRIIPCLDVKEGRVVKGIEFVQLRDIGDPVEIAKYYDESGADELVFLDITASTERRQTMLDVVSAVARKVFIPLTVGGGIRSLEDISSLLKAGADKVSLNTLAVESPSLIREAADRFGSQCIVVAIDVKFKDGEYYVYTYGGKQKTDLLAVEWAKQVAALGAGELLVTSMNQDGKQSGYDLSILEQLREVVDIPIIASGGAGNAEHVVEALEKVDAALLASILHDRKTTVEEVKHVCKSHNLPMRFVSTKMD

IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

C4L176

P0A5Y5

MABA_MYCBO

Beta-ketoacyl-acyl carrier protein reductase

Mycobacterium tuberculosis complex

MTATATEGAKPPFVSRSVLVTGGNRGIGLAIAQRLAADGHKVAVTHRGSGAPKGLFGVECDVTDSDAVDRAFTAVEEHQGPVEVLVSNAGLSADAFLMRMTEEKFEKVINANLTGAFRVAQRASRSMQRNKFGRMIFIGSVSGSWGIGNQANYAASKAGVIGMARSIARELSKANVTANVVAPGYIDTDMTRALDERIQQGALQFIPAKRVGTPAEVAGVVSFLASEDASYISGAVIPVDGGMGMGH

Part of the mycobacterial fatty acid elongation system FAS-II, which is involved in mycolic acid biosynthesis. Catalyzes the NADPH-dependent reduction of beta-ketoacyl derivatives, the second step of the FAS-II elongation cycle.

P0A5Y5

P0A9G7

ACEA_ECOL6

Isocitratase

Escherichia

MKTRTQQIEELQKEWTQPRWEGITRPYSAEDVVKLRGSVNPECTLAQLGAAKMWRLLHGESKKGYINSLGALTGGQALQQAKAGIEAVYLSGWQVAADANLAASMYPDQSLYPANSVPAVVERINNTFRRADQIQWSAGIEPGDPRYVDYFLPIVADAEAGFGGVLNAFELMKAMIEAGAAAVHFEDQLASVKKCGHMGGKVLVPTQEAIQKLVAARLAADVTGVPTLLVARTDADAADLITSDCDPYDSEFITGERTSEGFFRTHAGIEQAISRGLAYAPYADLVWCETSTPDLELARRFAQAIHAKYPGKLLAYNCSPSFNWQKNLDDKTIASFQQQLSDMGYKFQFITLAGIHSMWFNMFDLANAYAQGEGMKHYVEKVQQPEFAAAKDGYTFVSHQQEVGTGYFDKVTTIIQGGTSSVTALTGSTEESQF

Involved in the metabolic adaptation in response to environmental changes. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates.

P0A9G7

P45783

GSPN_AERSA

General secretion pathway protein N

Aeromonas

LQANRQYLFQGSLKPGPELPEEMKQGLPFLGQPDGQGRFPLRYQGRI

Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins.

P45783

Q59500

ILVC_MYCAV

Ketol-acid reductoisomerase type I

Mycobacterium avium complex (MAC)

MFYDDDADLTIIQGRKVGVIGYGSQGHAHSLSLRDSGVQVKVGLKEGSKSRAKVSEQGLDVDTPAAVAKWADVIMLLAPDTAQADIFKNDIEPNLSDGDALFFGHGLNIHFGLIKPPAEVTVAMVAPKGPGHLVRRQFVDGKGVPCLIAVDQDPTGKGEALALSYAKAIGGTRAGVIKTTFKDETETDLFGEQAVLCGGTEELVKAGFDVMVESGYPPEMAYFEVLHELKLIVDLMYEGGIARMNYSVSDTAEFGGYLSGPRVIDAGTKDRMREILRDIQNGDFVKKLVANVEGGNKQLEQLRKENVEHPIEVVGKRLRDLMSWVDRPITETA

Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.

Q59500

A4SDE2

END4_CHLPM

Endonuclease IV

Chlorobium

MKRVGAHVSIAGGVENAPLNATAIGAKAFALFTRNQRQWHSPPLQKASVDAFRRHCEAGGFDARHILPHDSYLINLGNPDPDKLERSRKAFIEEMERAETLGLVLLNFHPGSHLNAIGEEECLGLIADSINLAIKATDRVTAVIENTAGQGTNLGSRFEHLRAIIDRIEDRSRIGVCLDTCHLFASGYDLGTAEAAERTFEEFDRTVGMQYLKGMHLNDALRPLGSRLDRHACIGKGMIGIEGFRYIMQSPLFEEIPLILETPDSEGWKEEIELLYSLE

Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

A4SDE2

B3R0P2

TRMD_PHYMT

tRNA [GM37] methyltransferase

16SrX (Apple proliferation group)

MIIEIITIFPKFFDSFFEHSIIKRAIKKNKIIFQVHDLRNYSNNKHNQVDDSPYGGGAGMLLKFPPFYECLKKIKKSFSKVILLSPQGTLLNQKMAFEYVNEIKHLIILNGNYEGIDARILNYIDAEISIGDYILTGGEIATIVLIDVLVRLLPGVINSESYLEDSHQKDLLKYPQYTKPKIYQNQKVPEILLSGNHKNIKDWRYNQSLKNTFFKRPDILKKINLTEKQQKILLEIKKKLKEG

Specifically methylates guanosine-37 in various tRNAs.

B3R0P2

Q9FF78

PME46_ARATH

Pectin methylesterase 46

Arabidopsis

MSSYGRLDEHEQAKLEASRKTKKRIAIIAISSIVLVCIVVGAVVGTTARDNSKKPPTENNGEPISVSVKALCDVTLHKEKCFETLGSAPNASRSSPEELFKYAVKVTITELSKVLDGFSNGEHMDNATSAAMGACVELIGLAVDQLNETMTSSLKNFDDLRTWLSSVGTYQETCMDALVEANKPSLTTFGENHLKNSTEMTSNALAIITWLGKIADTVKFRRRRLLETGNAKVVVADLPMMEGRRLLESGDLKKKATIVVAKDGSGKYRTIGEALAEVEEKNEKPTIIYVKKGVYLENVRVEKTKWNVVMVGDGQSKTIVSAGLNFIDGTPTFETATFAVFGKGFMARDMGFINTAGPAKHQAVALMVSADLSVFYKCTMDAFQDTMYAHAQRQFYRDCVILGTVDFIFGNAAVVFQKCEILPRRPMKGQQNTITAQGRKDPNQNTGISIHNCTIKPLDNLTDIQTFLGRPWKDFSTTVIMKSFMDKFINPKGWLPWTGDTAPDTIFYAEYLNSGPGASTKNRVKWQGLKTSLTKKEANKFTVKPFIDGNNWLPATKVPFNSDF

Acts in the modification of cell walls via demethylesterification of cell wall pectin.

Q9FF78

Q9LSS7

RUBP1_ARATH

Deneddylase-1

Arabidopsis

MGNTSDDDKILSYEDVVLRRSDLDILNGPIFLNDRVIEFYLSFLSTVHSSTTISLIPPSIAFWISNCPDTEYLKDFMKPLNLRDKDLLILPVNDNSNVEVAEGGLHWSLLVYYKEANTFVHHDSYMGVNRWSAKQLFKAVSPFVSNGDASYKECTDTPQQKNGYDCGVFLLATARVICEWFSSGGMKNRDELWFANVKETVPDLVNHLREEILALIKKLMSESVSK

Processes the pre-form of the ubiquitin-like protein NEDD8/RUB1. Has the capacity to discriminate between NEDD8/RUB1 and ubiquitin. Has no SUMO protease activity.

Q9LSS7

A1S212

RPOC_SHEAM

Transcriptase subunit beta'

Shewanella

MKDLLKFLKQQGKTEEFEGIKIGLASPDLIRSWSFGEVKKPETINYRTFKPEREGLFCARIFGPVKDYECLCGKYKRLKHRGVICEKCGVEVTQTKVRRERMGHIELASPVAHIWFLKSLPSRIGLMLDMTLRDIERVLYFESYVVIEPGMTSLERGQMLTEENYLDALEEYGDEFEAKMGAEAVLDLLRAIDLEKEIEQMREELPSINSETRRKKVTKRLKLIEAFYTSGNKPEWMILKVLPVLPPDLRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLLDLAAPDIIVRNEKRMLQESVDALLDNGRRGRAITGSNKRPLKSLADMIKGKQGRFRQNLLGKRVDYSGRSVITVGPTLRLHQCGLPKKMALELFKPFIYGKLEGRGLATTIKAAKKMVEREVAEVWDVLDEVIREHPVMLNRAPTLHRLGIQAFEPVLIEGKAIQLHPLVCAAYNADFDGDQMAVHVPLTLEAQLEARALMMSTNNILSPANGEPIIVPSQDVVLGLYYISRERVNGRGEAMAFESVAEAEKAYRVGAAELHARVKVRITETIIGENGERTKQRRIVDTTVGRAILSQILPAGLSFDLVNQDMGKKQISKLLNTCYRQLGLKDTVIFADQLMYTGFQYATISGASVGINDMVIPEEKYSLVADAEAEVIEIQEQFQSGLVTAGERYNKVIDIWASANEKVSKAMMENLSSETVINRHGEEEKQKSFNSIYMMADSGARGSAAQIRQLAGMRGLMAKPDGSIIETPIVANFREGLNVLQYFISTHGARKGLADTALKTANSGYLTRRLVDVAQDLVIIEDDCGATEGLSMKPLIEGGDVVEPLRERVLGRVVAEDVMYPGTDEVLAPRNTLLDEAWCDKLEQHSVDEVQVRSVITCETDFGVCAKCYGRDLARGHIINMGEAIGVVAAQSIGEPGTQLTMRTFHIGGAASRASAENSVQVKNAGTLKLHNAKYVTNSDGKLVIVSRSSELAIIDELGREKERYKVPYGTVLDTKEGAEVNAGQIIANWDPHTHPIITEVAGSIKFVDMIDGVTITRQTDELTGLSSIVVLDVGQRTSAGKEMRPAVRLVDDNGNDLTIPGTDVPAQYFLPGNAIVNLDDNAKISVGDALARIPQESSKTRDITGGLPRVADLFEARRPKEPAILAEISGTISFGKETKGKRRLVITPNDGGDAYEEMIPKWRNLNVFEGEKVERGEVIADGPESAHDILRLRGIHNVANYIVNEVQDVYRLQGVKINDKHIEVIIRQMLRKCIITQAGDSEFLEGEQVEVARVKIANRDLEAAGKQPAKFERELLGITKASLATESFISAASFQETTRVLTEAAVGGKSDNLRGLKENVIVGRLIPAGTGFAYHKNRAKARASGEETAAPTITASEAEQNLADLLNLAGSQE

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

A1S212

Q86W10

CP4Z1_HUMAN

Laurate 7-monooxygenase

Homo

MEPSWLQELMAHPFLLLILLCMSLLLFQVIRLYQRRRWMIRALHLFPAPPAHWFYGHKEFYPVKEFEVYHKLMEKYPCAVPLWVGPFTMFFSVHDPDYAKILLKRQDPKSAVSHKILESWVGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLELFQHVSLMTLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIFSKFNQELHQFTEKVIQDRKESLKDKLKQDTTQKRRWDFLDILLSAKSENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSITWEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKLAPDHSRPPQPVRQVVLKSKNGIHVFAKKVC

A cytochrome P450 monooxygenase that catalyzes the in-chain oxidation of fatty acids . Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates lauric and myristic acids predominantly at the omega-4 and omega-2 positions, respectively . Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA). Displays an absolute stereoselectivity in the epoxidation of arachidonic acid producing the 14(S),15(R)-epoxyeicosatrienoic acid (EET) enantiomer . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) .

Q86W10

P54045

RS5_METJA

30S ribosomal protein S5

Methanocaldococcus

MRFNIDEWEPKTTIGRMVKEGQITDIDYILDNNLPILEPEIVDALLPDLEEKVLDVKLVQRMHKSGRRARFRATVVVGNRNGYVGVGKGKAKEVGPAIRKAIAQAKKNIIRVKRGCGSWECGCGTPHSIPYKGYGKCGSTAIEILPAPKGVGLVAGDVAKAVLGLAGIKDVWTKTFGETRTTYNFAMATFEALKSLNFTRTMEKHKEKLGIVEGRVL

With S4 and S12 plays an important role in translational accuracy.

P54045

A4QJM2

RK20_AETGR

50S ribosomal protein L20, chloroplastic

Aethionema

MTRIKRGYIARRRRTKIRLFASSFRGAHSRLTRTMTQQRIRALVSAHRDRGRRKRDFRRLWITRINAVIQEMEVFNSYNRFIHNLYKKQVLLNRKILAQIALLNRSCLYTISNEIIK

Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

A4QJM2

Q8CDT7

CBCO1_MOUSE

Ciliary-associated calcium-binding coiled-coil protein 1

Mus

MNFSIEQYSKFMTLLDMLLHNLQTLHMSLEDSIKWLGEVMAEIGPNHSQKSEDFHVFEVKEANAIIDYLKISLFQHYRLYEFLFYSTREEIVIGTEQTIEVVKPADYPFPAPLEEGISLDTYSTFIEPLPTPDMEQKVLDQEQGTQEALLESEMREEDPLGGFTIDDVKSALERVTDEVLISMQKEISEKLQVQEEAFNARIEKLKKA

Calcium-binding protein . May be involved in the control of sperm flagellar movement .

Q8CDT7

Q9VE04

RM55_DROME

39S ribosomal protein L55, mitochondrial

Sophophora

MLLKQLPQAVQQIRCISSATTAVTRLHRSVYCRLYPTVVVQPDGSTINIRYHEPRKIIKLPLDLSTLTDAERRARLEARKPRKKVKIMEEVEDNFNAKKYMKYIKKK

Involved in mitochondrial biogenesis and G2/M phase cell cycle progression.

Q9VE04

A1V9E1

ILVD_DESVV

Dihydroxy-acid dehydratase

Desulfovibrio

MRSKKMTHGLEKAPHRSLLHALGLTREELARPLVGVVNAANEVVPGHIHLDDIAEAVKAGVRAAGGTPLEFPAIAVCDGLAMNHEGMRFSLPSRELIADSIEIMATAHPFDALVFIPNCDKSVPGMLMAMLRLDVPSVMVSGGPMLAGATLAGRADLITVFEGVGRVQRGDMTEAELDELVEGACPGCGSCAGMFTANSMNCLAETIGLALPGNGTTPAVTAARIRLAKHAGMKVMEMLERNIRPRDIVTEKAVANAVAVDMALGCSTNTVLHLPAVFAEAGLDLTLDIFDKVSRKTPNLCKLSPAGHHHIQDLHAAGGIPAVMAELDSIGLIDRSAMTVTGRTVGENLDALGAKVRDADVIRSVDAPYSPQGGIAILKGSLAPGGAVVKQSAVAPEMMVREAVARVFDSEEAACEAIMGGRIKAGDAIVIRYEGPKGGPGMREMLTPTSAIAGMGLGADVALITDGRFSGGTRGAAIGHVSPEAAEGGPIGLVQEGDRIRIDIPARALDLLVDEDELARRRAVFVPVEKEITSPLLRRYARMVSSAATGARQR

Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.

A1V9E1

B2UQL7

G1092_AKKM8

Glycosyl hydrolase family 109 protein 2

Akkermansia

MSIFSSRRQFLKSLGLAAGAAAAGNALPGKAVEIPAGDHLWKSASPAAPRPSGSTYMGGFKAPRLGRIRLAFIGVGGRGFSHLAQMCVMDGVEIVGICDLKEELTKRGVDRVLSRMGKSPLGYSGGDMEYLTMLKELKPDAVIISTDWSSHARIACDSMKHGAHAFVEVPLAVSLEELWSLVDTSEATRKHCMMMENVNYGRDELMFLNMVRQGVIGDLLHGEAAYIHCLVTQLGDTRGEGAWRPEYHTRINGNLYPTHGLGPVAQYMNLERGEDRFCRVAAFASPALGRNAYAKKHLPADHRWNNTPFICGDMNTAVVKTQLGRTILVQLDETSPRPYSRANLIQGTEGTLAGFPTRVAGEKLGNGNYHEWIEGREKLAAIYEKYDHPLWKRIGELATKMGGHGGMDFVMLSRIVECLRNGEPMDQNVYEGASWSSLLPLTARSIAQGGMPVEFPDFTRGDWKTTMPLAVVS

Glycosidase.

B2UQL7

B0VNK1

ATPD_ACIBS

F-type ATPase subunit delta

Acinetobacter calcoaceticus/baumannii complex

MAELLTLARPYAKAAFAYASEQGATDNWSNALQVLSAAVQDEAFSAYLNRPEHTPAEQVKLFAKVLGEDQSQAVSNFLTLLADNDRLVLLPEIAAEYEQLKSQNNNNVDVVIESAFPLTAEQEQLLKSALEKRFNSTVTVSVEVKPELIAGVVIRAGDQVIDDSALNKLEKMRTRLLA

This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

B0VNK1

B9DUP5

RNZ_STRU0

tRNase Z

Streptococcus

MELQFLGTGAGQPAKQRNVSSLVLKLLDEINEVWMFDCGEGTQRQILETSIKPRKIQKIFITHLHGDHIFGLPGFLSSRAFQASEEQTDIEIFGPLGIKSFVQNSLAISGTRLPYKIHFHEFTDKDMGKIMETDKFLVYAEKLAHTIFCMGYRVVQKDLEGTLDAEALKKAGVPFGPLFGKIKNGQDIVLDDGRQILAKDYISEPKKGKVITILGDTRKTPASQRLALNADVLVHESTYGKGDDRIARNHGHSTNMQAAQIAKDANVKRLLLNHVSARFLSRDCRQMEKDAASLFENVKIVKDLEEVTI

Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

B9DUP5

C6E7L6

RLMH_GEOSM

rRNA (pseudouridine-N3-)-methyltransferase RlmH

unclassified Geobacter

MRLKLLWVGKTQESWVRTGIEEYAGRIRRYAPLEILEAREEKGAQAAAMRERECERLAKLIPKGGRLVLLDERGEAMTSPELASFLSKNRDQGTQDLVFAIGGAYGFTDAFRSQAFKSISLSRMTLTHQMVRVFLLEQIYRGFTIINGEPYHHE

Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

C6E7L6

A8YXL4

RS17_LACH4

30S ribosomal protein S17

Lactobacillus

MSETNERNRRHVYQGRVVSDKMDKTIVVVVDTYKNHPVYSKRIRYSKKYYAQDENNEAKVGDTVRIMETRPLSRKKRFRLVKIVKKSV

One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.

A8YXL4

P48145

NPBW1_HUMAN

G-protein coupled receptor 7

Homo

MDNASFSEPWPANASGPDPALSCSNASTLAPLPAPLAVAVPVVYAVICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNLRQLITCRAAA

Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals. Has a higher affinity for neuropeptide B.

P48145

B2VFA0

YIHI_ERWT9

Der GTPase-activating protein YihI

Erwinia

MKQPARTSQVKKPAARVKRKTREEINQEARDRKREKKHSGHASGSRANPATVSQKGDKSQSVKDPRIGSKKAIALGTDAPVRQPANPVKAAKPAVEKKPRLTPEEELAKLENDERLDALLDRLENGEALSAEDQAWLDQSLDRIDVLMEQLGIALDDDAEDEKAEEDMYRLLKGSHRTPE

A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis.

B2VFA0

A6TBX4

NUOA_KLEP7

NUO1

Klebsiella

MRMSTSTEVIAHHWAFAIFLIIAIGLCCLMLVGGWYLGGRARARSKNTPFESGIDSVGSARLRLSAKFYLVAMFFVIFDVEALYLYAWSTSIRESGWVGFVEAAIFILVLLAGLVYLVRIGALDWTPARSRRTLVNPETDSPTNRHMQ

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

A6TBX4

Q8GSM3

LOX22_HORVU

LOX2:Hv:2

Hordeum

MQTATKPLVGARAVPLSRRASFLVAEARRKPSTNARRTRVGSTSTTTTTTTILTDVNGPALTTVAKPGHQYDLKQTVEMKATVSVHMKSFWWSDEKKERARDWAYDLILGSWLTLELVSSELDPKTGQEHDVISGKLKHSRETEKDYDLYEAIFTCRHRLAPSGAVRLVNYHHTEMLLGEVKIFPAGEDPTKSSAVTLFHCQSWIDPSHCSPDKRTFFPVEKSYIPSQTPKGVEKLRKSELEALRGNGCGERKKHDRIYDYDVYNDLGKPESKRPVLGGKEHPYPRRCRTGRPRSKTDPSSEEESHKKGEMYVPRDETFTERKEQAFLTKQLLSQLHGLCTGLKVNKDILPSFPTLASIDALYDDDFRNQPVQPEGGKVRLILDLLAKELVHLVKLEGAEFVEGIRRVFKFETPEIHDMDKLAWFRDEEFARQTLAGMNPLSIQLVTELPIVSKLDELKYGPADSLITKELIEKQINRIMTAEEAVAQKKLFMLDYHDLLLPYVHRVRKLDNKTMYGSRTLFFLADDGTLRPIAIELTRPKSPHKQQWRKVFTPGSGYSGSVTGSWEWQLAKIHVLSHDTGYHQLVSHWLRTHCCVEPYVIAANRQLSQMHPIYRLLHPHFRFTMEINAQARGMLICADGIIEKTFSPGEFSMEISSAAYDKQWRFDMEALPEDLIRRGMAVRGEDGKLELAIEDYPYANDGLLVWDAIKQWASDYVAHYYPCAVDIVDDEELQDWWTEVRTKGHPDKQDEPWWPELDCHESLVQVLATIMWVTSAHHAAVNFGQYPMAGYVPNHPSIARRNMPCEMGPEEMLAFKAAPEKVWLDTLPSQLQTVMVMATLDLLSSHASDEEYMGTHQEPAWQRDGEVDKAFQVFQKKMRDIAEQVEEWNKDDSRRNRHGAGVVPYVLLRPLNGNPMDAKTVMEMGIPNSISI

Plant lipoxygenase may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding. This enzyme exhibits linoleate 13-lipoxygenase activity.

Q8GSM3

Q9Y597

KCTD3_HUMAN

Renal carcinoma antigen NY-REN-45

Homo

MAGGHCGSFPAAAAGSGEIVQLNVGGTRFSTSRQTLMWIPDSFFSSLLSGRISTLRDETGAIFIDRDPAAFAPILNFLRTKELDLRGVSINVLRHEAEFYGITPLVRRLLLCEELERSSCGSVLFHGYLPPPGIPSRKINNTVRSADSRNGLNSTEGEARGNGTQPVLSGTGEETVRLGFPVDPRKVLIVAGHHNWIVAAYAHFAVCYRIKESSGWQQVFTSPYLDWTIERVALNAKVVGGPHGDKDKMVAVASESSIILWSVQDGGSGSEIGVFSLGVPVDALFFIGNQLVATSHTGKVGVWNAVTQHWQVQDVVPITSYDTAGSFLLLGCNNGSIYYIDMQKFPLRMKDNDLLVTELYHDPSNDAITALSVYLTPKTSVSGNWIEIAYGTSSGAVRVIVQHPETVGSGPQLFQTFTVHRSPVTKIMLSEKHLVSVCADNNHVRTWTVTRFRGMISTQPGSTPLASFKILSLEETESHGSYSSGNDIGPFGERDDQQVFIQKVVPITNKLFVRLSSTGKRICEIQAVDCTTISSFTVRECEGSSRMGSRPRRYLFTGHTNGSIQMWDLTTAMDMVNKSEDKDVGGPTEEELLKLLDQCDLSTSRCATPNISPATSVVQHSHLRESNSSLQLQHHDTTHEAATYGSMRPYRESPLLARARRTESFHSYRDFQTINLNRNVERAVPENGNLGPIQAEVKGATGECNISERKSPGVEIKSLRELDSGLEVHKIAEGFSESKKRSSEDENENKIEFRKKGGFEGGGFLGRKKVPYLASSPSTSDGGTDSPGTASPSPTKTTPSPRHKKSDSSGQEYSL

Accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) up-regulating its cell-surface expression and current density without affecting its voltage dependence and kinetics.

Q9Y597

Q72HM3

FABZ_THET2

Beta-hydroxyacyl-ACP dehydratase

Thermus

MDIREILKVLPHRYPFLLVDRVLEADERRFKALKNVTFNEPHFQGHFPGHPVMPGVLILEAMAQAAVGALVRQPGFPQGGLAFLAGVEGARFRRPVYPGDTLILEGELLAFRRGVGKVAVRALVEGEERASATLTFVLQGAS

Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

Q72HM3

Q8JI40

CRVP_GLOBL

Cysteine-rich venom protein ablomin

Gloydius

MIVFIVLPILAAVLQQSSGNVDFDSESPRKPEIQNEIVDLHNSLRRSVNPTASNMLKMEWYPEAAANAERWAYRCIEDHSSPDSRVLEGIKCGENIYMSPIPMKWTDIIHIWHDEYKNFKYGIGADPPNAVSGHFTQIVWYKSYRAGCAAAYCPSSEYSYFYVCQYCPAGNMRGKTATPYTSGPPCGDCPSACDNGLCTNPCTQEDVFTNCNSLVQQSNCQHNYIKTNCPASCFCHNEIK

Blocks contraction of smooth muscle elicited by high potassium-induced depolarization, but does not block caffeine-stimulated contraction. Since high potassium-treatment activates voltage-gated channels and caffeine exposure activates ryanodine receptors, this toxin may target L-type voltage-gated calcium channels (Cav) (and not ryanodine receptors) on smooth muscle . This toxin also shows a little inhibition on cyclic nucleotide-gated CNGA1 channel .

Q8JI40

A0KF26

RL22_AERHH

50S ribosomal protein L22

Aeromonas

MEAIAKHRYARTSAQKARLVADQVRGLSVDKALNILTFSPKKAAALVKKVLESAIANAEHNEGADIDALRVATIMVDEGPSMKRIRPRAKGRADRILKRTAHITVVVSDAKAGR

The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.

A0KF26

Q635G3

BIOD_BACCZ

Dethiobiotin synthase

Bacillus cereus group

MSGFFITATDTEVGKTVVAGALAGVFRELGYNIGVYKPLQSGHVASNPEGDAARLKALSGVPTKEDEICPYSIEEPLAPRLAMKRAGRTVTLKDIIHHYNERLKEFNSLFVEGAGGLAVPYTEDALVIDFAKELQLPLIVVARPTLGTVNHTVLTIAYAKAHGLTVAGVILSGCKECEMERVQENKVMIEELSGVPVLGLLPFFEGEFTKKEVLESAKEYIMISKLEECIRNESTVAHTSSN

Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.

Q635G3

Q04KR9

DAPA_STRP2

4-hydroxy-tetrahydrodipicolinate synthase

Streptococcus

MSYQDLKECKIITAFITPFHEDGSINFDAIPALIEHLLDHHTDGILLAGTTAESPTLTHDEELELFAAVQKIVNGRVPLIAGVGTNDTRDSIEFVKEVAEFGGFAAGLAIVPYYNKPSQEGMYQHFKAIADASDLPIIIYNIPGRVVVELTPETMLRLADHPNIIGVKECTSLANMAYLIEHKPEEFLVYTGEDGDAFHAMNLGADGVISVASHTNGDEMHEMFIAIAESDVKKAAAIQRKFIPKVNALFSYPSPAPVKAVLNYMGFEAGPTRLPLVPAPEEDAKRIIKVVVDGDYEATKATVTGVLRPDY

Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).

Q04KR9

B7IGQ4

PLSX_THEAB

Phosphate-acyl-ACP acyltransferase

Thermosipho

MKKIAIDLMGGDYAPEEILAGALSFAKENEDVELYLVGIEENFKDVQLPKNCVKVVTDDFLPMDVKPTEAVRRRKSTMYVSCQLAREKKVDAVVSAGNTGALLACATFVVGRIKGIERPTLAVPIPTKNDFCVLADAGANIDVKPSNLLQFAIMGVEYAKLLGKDNPTIGLLNVGTEENKGTQKEKEAFQILKERFGNQFVGNVEGNDLNAGKVDVVVADGFHGNIAMKTMEGAAKMITELIKSEVKKNIISALGALLMKPVFSSLKNKLDPKKYGGTFFIGVEGVVVKAHGNSNRTAIFNALKVAKKGVEEKLPLKIKEALLKCAE

Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.

B7IGQ4

A2C6X2

ATPF2_PROM3

F-type ATPase subunit b'

Prochlorococcus

MTSLLLFGAGGLFDFDATLPLMALQVVLLTFILNALFFRPVGRVVEEREVYVTTSRAEAKQKLAEAEKLELELKEQLKSARIAAQQLIQEAEKDSEQLYREALAIANADANAAREKARREIDAQRDSALTQLKGDAEKLGDLIVNRLLAAK

Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria.

A2C6X2

Q4KLT6

FL2D_XENLA

Wilms tumor 1-associating protein

Xenopus

MTNEEPLPKKVRLNESDFKVLPREDLLQRWKQYEAYVQALENKYTDLNSNDVTGLRESEEKLKQQQQESARRENILVMRLATKEQEMQECTNQIQHLKQVQQPSVAQLRATMVDPAINLFFIKMKAELEQTKDKLEQAQNELSAWKFTPDSQTGKKLMAKCRMLIQENQELGRQLSQGRIAQLEAELALQKKYSEELKSSQDELNDFIIQLDEEVEGMQSTILVLQQQLKDSRQQLSQFQQQIQISGNRTPSSEPKDEGETSGKDCGRILNGPSNGGSSLQRTHSSAGLYREGSSTEDDFSASPINEGKLSNHSQERTSRDGSSYINPLSTGYESVDSPTGSENSLTHQSNDTDSNHDSQEEKPVSGKGNRTVSSRHLQNGLDSSVNVQGSVL

Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing.

Q4KLT6

Q1GVN5

RS11_SPHAL

30S ribosomal protein S11

Sphingopyxis

MAREPQRLRRRERKNISSGVAHVNATFNNTMITITDAQGNAIAWSSAGMMGFKGSRKSTPYAAQVCAEDAGKKAAEHGVRTLEVEVKGPGAGRESALRALQAVGFHITSIRDVTPIPHNGVRPAKRRRV

Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.

Q1GVN5

C0K3N1

TXVE_BITAR

VEGF-F

Bitis

MAAYLLAVAILFCIQGWPSGTVQGEVRPFMEVYQRSVCQPRETLVSILEEYPDKISKIFRPSCVAVLRCGGCCSDESLTCTSVGERTVELQVMQVTPKTLSSKIKVMKFREHTACECRPRSGSRVNIGKHKRSPEEGEREPSSPLTPGSL

Snake venom VEGFs that may contribute to venom dispersion and prey subjugation by inducing vascular permeability and hypotension. This protein induces an increase in capillary permeability after intradermal injection, as well as a drastic hypotensive effect after intravenous injection. The hypotension is mediated by nitric oxide (NO), which is produced by VEGF-activated endothelium NO synthase. Also induces angiogenesis in vitro, probably through VEGF receptor (KDR/VEGFR-2) signaling.

C0K3N1

Q8DSD7

RS6_STRMU

30S ribosomal protein S6

Streptococcus

MAKYEILYIIRPNIEEEAKNALVARFDAVLTDNGATIVESKDWEKRRLAYEIQDFREGLYHVINVETEDAHALNEFDRLSKINNDILRHMIVKLDA

Binds together with S18 to 16S ribosomal RNA.

Q8DSD7

C3P8M5

LEPA_BACAA

Ribosomal back-translocase LepA

Bacillus cereus group

MNKEERAKRQSKIRNFSIIAHIDHGKSTLADRILEKTNALTQREMKAQLLDSMDLERERGITIKLNAIQLNYKAKDGEEYILHLIDTPGHVDFTYEVSRSLAACEGAILVVDAAQGIEAQTLANVYLALDNNLEILPVINKIDLPSADPERVRQEVEDVIGLDASEAVLASAKAGIGIEEILEQIVEKVPAPTGDSEEPLQCMIFDSLYDPYRGVIAYIRVVNGTVKVGDKVRMMATGKEFEVTEVGVFTPKTTQRDELTVGDVGFLAASIKNVGDTRVGDTITHAKRPAAEPLAGYRKLNPMVFCGLYPIDSARYNDLRDALEKLELNDSALEFEPETSQALGFGFRCGFLGLLHMEILQERIEREFKIDLITTAPSVIYKVFLTNGEDMIVDNPSNMPDPQTIDRVEEPFVKAAIMVPNDYVGAVMEICQGKRGTFIDMQYLDETRVTLTYEIPLSEIVYDFFDQLKSNTKGYASFDYELIGYKPSKLVKMDILLNSEQVDALSFIVHRDSAYDRGKVIVEKLKELIPRQQFEVPIQATIGNKVVARSTIKAMRKNVLAKCYGGDISRKRKLLDKQKEGKKRMKSVGSVEVPQEAFMAVLKMDDN

Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

C3P8M5

O35652

LHX8_MOUSE

LIM/homeobox protein Lhx7

Mus

MYWKSDQMFVCKLEGKEVPELAVPREKCPGLMSEECGRPAALAAGRTRKGAGEEGLVNPEGAGDEDSCSSSAPLSPSSSPQSMASGSVCPPGKCVCSSCGLEIVDKYLLKVNDLCWHVRCLSCSVCRTSLGRHTSCYIKDKDIFCKLDYFRRYGTRCSRCGRHIHSTDWVRRAKGNVYHLACFACFSCKRQLSTGEEFALVEEKVLCRVHFDCMLDNLKREVENGNGISVEGALLTEQDVNHPKPAKRARTSFTADQLQVMQAQFAQDNNPDAQTLQKLAERTGLSRRVIQVWFQNCRARHKKHVSPNHSSSAPVTAVPSSRLSPPMLEEMAYSAYVPQDGTMLTALHSYMDAHQQLLDSSPCYPIQ

Transcription factor involved in differentiation of certain neurons and mesenchymal cells.

O35652

B4U741

EFG_HYDS0

Elongation factor G

unclassified Hydrogenobaculum

MPRTVPIQDLRNIGIVAHIDAGKTTTTERILYYTGKTYKIGEVHEGAATMDWMPQEKERGITITAATTACYWAGKQINIIDTPGHVDFSVEVVRSMRVLDGIIFIFSAVEGVQPQSEANWRWADKFNVARIAFINKLDRLGADFYRVYDEIVKKLTIKPVAIQIPIGTEDNFVGVVDLMNMNAIIWLEETLGAKYEIRDIPEEYKAKAQEWREKMVESIAETDDTLMEKYLEGQEISTDELKQALRKATINKQLVPVLCGSSFKNKGVQPLLDAVVDYLPSPLDVPSVVGINPKTVQEETRLPEDDQPFCAYIFKVVSDPYAGQLSYFRVFSGKVQAGSYVLNSTKDKKERVGRLLLMHANTREDITEVAAGEIAAAVGVDAATGDTICDEKSPIILEKLEFPEPVISMAIEPKTKKDQEKLSQVLNKFMKEDPTFKASMDPETGQTLIHGMGELHLEIMVDRMKREYNIEVNVGKPQVAYKEAIKGKAVAEGKFIRQTGGRGQYGHVVIEVEPLERGSGFVFENAIVGGVIPKEFIPPVEEGIKEAMENGVLAGYPVVDVKVKLFDGSYHEVDSSEIAFKIAGSMAFKEAAKKASVVLLEPIMEVEVETPDDYVGDVIGDLNSRRGKIMGMENKGIITSIKAHVPLSEMFGYATNLRSLTQGRGTFIMKFSHYSEAPQSITEKVVGERTHT

Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.

B4U741

B9DN91

RS4_STACT

30S ribosomal protein S4

Staphylococcus

MARFRGSNWKKSRRLGISLSGTGKELEKRPYAPGQHGPNQRKKLSEYAIQLREKQKLRYLYGITERQFHNTFIEAGKQSGVHGENFMRLLARRLDAVVYALGLARTRRQARQLVGHGHIEVDGKRVNIPSYTLKPGQVVSVREKSQKLDIIQESVEINNFVPEYLDFDEEKLSGTFVRVPERSELPAEINEQLIVEYYSGK

With S5 and S12 plays an important role in translational accuracy.

B9DN91

A4X491

GATB_SALTO

Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B

Salinispora

MTTTLPAYDEVVARYEPVIGLETHVELGTNTKMFCGCPTDFGGAPNTRVCPVCLGLPGSLPVANRAAVEATIRIGLALNCSIAEWCRFARKNYYYPDMPKNYQISQYDEPLCVDGYLDVEVDGEPVRISIERVHMEEDTGKTLHVGGATGRIHGATESLVDYNRAGIPLVEIVTKPIPGAGAMAPEVARAYVTELRDVLRSLGVSDVRMEEGSLRCDVNTSLNLPGEQWGTRTETKNVNSLRSVERAVRSEMIRQASVLEGGGRITQETRHFHEDTGDTTSGRSKETATDYRYFPEPDLVPVAPDPTWVAELKAALPELPRLHRRRLQQEWGLSDLDMQSILNAGAVELIEATIAAGATPTAARKWWLGELSRRANEAGVELADIGATPEQVAELQGLVDAGKLTDKLARTVLEHVVAGEGSPAKIMADRNLEVVSDTGALTAAVDEAIAANPAIADKVRGGKVAAAGALVGAVMKTTRGQADAKTVRELILERLGVQG

Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).

A4X491

B4SBU6

RS10_PELPB

30S ribosomal protein S10

Pelodictyon

MAVQQKIRIKLKSYDHSLVDKWALRIIDVVKQTDAIIFGPIPLPTKSHVYTVNRSPHVDKKSREQFSFSSHKRLIEIINPTSRTIDMLMKLELPSGVDVEIKS

Involved in the binding of tRNA to the ribosomes.

B4SBU6

B6JN80

NTPP_HELP2

Nucleotide pyrophosphatase

Helicobacter

MELILGSQSSARANLLKEHGIKFEQKALYFDEESLKTTDPREFVYLACKGKLEKAKELLANNCVIVVADSVVSVDNRMQRKAQSKREALEFLKRQNGNEIEVLTCSALISPKLEWLDLSVFRARLKAFDPSEIEKYLESGLWQESAGCVRLEDFHRPYIKSSSKNLSVGLGLNVEGLLGALKLGAKIASL

Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

B6JN80

A6UC30

UREF_SINMW

Urease accessory protein UreF

Sinorhizobium

MAEHADTQALLRLVTWLSPAFPVGSFSYSGGLEQAIHQGLVTSADDLRLWCETLLERGNTWNDALLLSESYRAYGDAQRLIAVSELAEALAGSRERHMETMLLGEAFLAAAGHWPHPSLAVLGTKAAYPVSVGAVAGAHRTGLKPALAAFLNATVSNAVSVAIRCGITGQRDGVGVLARVEDTIGAVVARAAAASLEDLGGATFIAEIASLKHENLHSRLFRS

Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.

A6UC30

P0CW31

VPB16_MYCTU

Putative antitoxin VapB16

Mycobacterium tuberculosis complex

MALWYQAMIAKFGEQVVDAKVWAPAKRVGVHEAKTRLSELLRLVYGGQRLRLPAAASR

Putative antitoxin component of a possible type II toxin-antitoxin (TA) system. The cognate toxin is VapC16.

P0CW31

A0ZZ18

PSBK_GOSBA

Photosystem II reaction center protein K

Gossypium

MLNIFNLICICFNSALFSSSFLFAKLPEAYAFLNPIVDFMPVIPVLFFLLAFVWQAAVSFR

One of the components of the core complex of photosystem II (PSII). PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.

A0ZZ18