conclusions
string | copyrights
string | doi
string | results
string | keywords
list | publication_date
string | abstract
string | authors
list | journal
string | methods
string | pubmed_id
string | title
string | isbn
string | publication_type
string | sections
list | publisher
string | publisher_location
string | language
string |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
null | null |
10.1249/JSR.0000000000000221
| null |
[] |
2016-01-09
| null |
[
{
"affiliation": "Department of Rehabilitation Medicine, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.",
"collective": null,
"firstname": "Jeehae",
"initials": "J",
"lastname": "Oh"
},
{
"affiliation": null,
"collective": null,
"firstname": "Hyun-Mi",
"initials": "HM",
"lastname": "Oh"
},
{
"affiliation": null,
"collective": null,
"firstname": "Jong In",
"initials": "JI",
"lastname": "Lee"
}
] |
Current sports medicine reports
| null |
26745169
|
Horseback Riding-Related Vertebral Compression Fracture from Walking in Women with Low Bone Mineral Density: Reports of Two Cases.
| null | null | null | null | null | null |
null |
© 2024 The Author(s). Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology.
|
10.1002/rcr2.70020
10.1056/NEJMoa2026834
10.1097/RHU.0000000000001905
10.1016/j.blre.2022.100971
10.1007/s11239-021-02608-y
10.1016/j.chest.2022.10.011
10.1111/bjd.20805
10.1002/art.41743
10.1007/s00296-022-05266-2
10.1111/ijd.16635
10.1001/jamaoto.2021.4092
10.1111/imj.15742
10.1016/j.jdcr.2022.02.022
10.1182/blood.2020010177
10.1038/s41409-022-01774-8
| null |
[
"VEXAS",
"interstitial lung disease",
"orbital cellulitis"
] |
2024-09-10
|
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) syndrome is a rare and recently identified disease resulting from a somatic mutation in the X-linked UBA1 gene in cells of myeloid lineage. It can present in a myriad of ways with the potential to affect various organ systems, including the lungs. VEXAS is usually steroid responsive, but no strong data exists for the use of a steroid-sparing agent. There is limited emerging evidence for haematopoietic stem cell transplantation in a select number of cases. Regardless, prognosis for this condition is poor and a treatment algorithm remains a priority. Herein, we present a case of VEXAS that came to attention with discovery of a relatively asymptomatic interstitial lung disease and led to recurrent febrile episodes with evolving multi-organ involvement.
|
[
{
"affiliation": "Department of Thoracic Medicine The Prince Charles Hospital Chermside Queensland Australia.",
"collective": null,
"firstname": "Sushil",
"initials": "S",
"lastname": "Agwan"
},
{
"affiliation": "Department of Thoracic Medicine The Prince Charles Hospital Chermside Queensland Australia.",
"collective": null,
"firstname": "Lai-Ying",
"initials": "LY",
"lastname": "Zhang"
},
{
"affiliation": "Department of Thoracic Medicine The Prince Charles Hospital Chermside Queensland Australia.",
"collective": null,
"firstname": "Thomas",
"initials": "T",
"lastname": "Baker"
},
{
"affiliation": "Faculty of Medicine The University of Queensland Herston Queensland Australia.\nDepartment of Clinical Immunology and Allergy Royal Brisbane and Women's Hospital Herston Queensland Australia.",
"collective": null,
"firstname": "Michael",
"initials": "M",
"lastname": "Lane"
},
{
"affiliation": "Anatomical Pathology The Prince Charles Hospital Chermside Queensland Australia.",
"collective": null,
"firstname": "David",
"initials": "D",
"lastname": "Godbolt"
},
{
"affiliation": "Department of Thoracic Medicine The Prince Charles Hospital Chermside Queensland Australia.\nFaculty of Medicine The University of Queensland Herston Queensland Australia.",
"collective": null,
"firstname": "John A",
"initials": "JA",
"lastname": "Mackintosh"
}
] |
Respirology case reports
| null |
39253323
33108101
36251488
35595613
34817788
36272567
34632574
33779074
36617363
36890121
35050349
35419965
35391910
33619558
35941354
|
A vexing case of a 73-year-old man with fevers, orbital cellulitis, and asymptomatic interstitial lung disease.
| null | null | null | null | null | null |
null | null |
10.1007/s12104-007-9077-1
| null |
[] |
2009-07-29
|
Resistance of cancer cells to oncotherapeutics designed to trigger programmed cell death (a.k.a. apoptosis) greatly limits clinical efficacy. The human FLN29 protein may play a role in this process via protein-protein interactions. Here we report the NMR spectral assignment of the N-terminal TRAF2/6-RING-zinc finger-like domain of this protein.
|
[
{
"affiliation": "Centre for Biologics Research, Biologics and Genetic Therapies Directorate, Health Canada, 251 Sir Frederick Banting Driveway, A/L 2201E, Tunney's Pasture, Ottawa, ON, Canada.",
"collective": null,
"firstname": "Simon",
"initials": "S",
"lastname": "Sauvé"
},
{
"affiliation": null,
"collective": null,
"firstname": "Geneviève",
"initials": "G",
"lastname": "Gingras"
},
{
"affiliation": null,
"collective": null,
"firstname": "Rémy A",
"initials": "RA",
"lastname": "Aubin"
},
{
"affiliation": null,
"collective": null,
"firstname": "Derek J",
"initials": "DJ",
"lastname": "Hodgson"
},
{
"affiliation": null,
"collective": null,
"firstname": "Yves",
"initials": "Y",
"lastname": "Aubin"
}
] |
Biomolecular NMR assignments
| null |
19636918
|
NMR assignment of the N-terminal TRAF-like RING zinc finger domain of human FLN29.
| null | null | null | null | null | null |
null | null | null | null |
[] |
1979-10-01
|
The bone mineral content of the upper ends of the tibia and the fibula was measured in 27 patients with tibia shaft fracture. The bone mineral decreased rapidly after fracture, the loss continuing for about 5 months. Later, towards the end of the first year after the injury, there was a slow restoration of mineral but no return to initial values in most instances. Although the average maximum loss was approximately 45%, only 25% of the initial bone mineral was missing after one year.
|
[
{
"affiliation": null,
"collective": null,
"firstname": "S M",
"initials": "SM",
"lastname": "Andersson"
},
{
"affiliation": null,
"collective": null,
"firstname": "B E",
"initials": "BE",
"lastname": "Nilsson"
}
] |
Clinical orthopaedics and related research
| null |
535229
|
Changes in bone mineral content following tibia shaft fractures.
| null | null | null | null | null | null |
Mutant KRAS monitoring in cfDNA using serial blood collection might reflect the disease status more accurately than invasive BM examinations, especially in patients with MM whose primary lesions have extra-BM locations. It could also help predict treatment responses and outcomes.
|
Copyright © 2023 Elsevier B.V. All rights reserved.
|
10.1016/j.cca.2023.117590
|
During treatment, the MAF was correlated with serum immunoglobulin A and free light chain-kappa levels. After the second autologous peripheral blood stem cell transplantation, the KRAS MAF became immediately positive after confirming MRD negativity using PCs from BM. Shortly thereafter, the patient experienced clinical relapse primarily involving bone lesions.
|
[
"Cell-free DNA",
"KRAS mutation",
"Liquid biopsy",
"Multiple myeloma"
] |
2023-10-15
|
Multiple myeloma (MM), a neoplasm of plasma cells (PCs), is a highly heterogeneous disease with multifocal dissemination throughout the body. Minimal residual disease (MRD) detected using PCs in bone marrow (BM) is important for MM management; however, frequent invasive examinations impose a significant burden on patients.
Analysis using plasma cell-free DNA (cfDNA) might represent an alternative tool for disease monitoring. In this study, we observed the disease status in a patient with MM by examining the KRAS mutation allele frequency (MAF) in plasma cfDNA using digital PCR.
During treatment, the MAF was correlated with serum immunoglobulin A and free light chain-kappa levels. After the second autologous peripheral blood stem cell transplantation, the KRAS MAF became immediately positive after confirming MRD negativity using PCs from BM. Shortly thereafter, the patient experienced clinical relapse primarily involving bone lesions.
Mutant KRAS monitoring in cfDNA using serial blood collection might reflect the disease status more accurately than invasive BM examinations, especially in patients with MM whose primary lesions have extra-BM locations. It could also help predict treatment responses and outcomes.
|
[
{
"affiliation": "Division of Metabolism and Biosystemic Science, Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa, Japan. Electronic address: [email protected].",
"collective": null,
"firstname": "Masayo",
"initials": "M",
"lastname": "Yamamoto"
},
{
"affiliation": "Division of Metabolism and Biosystemic Science, Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa, Japan.",
"collective": null,
"firstname": "Motohiro",
"initials": "M",
"lastname": "Shindo"
},
{
"affiliation": "Division of Metabolism and Biosystemic Science, Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa, Japan.",
"collective": null,
"firstname": "Takuya",
"initials": "T",
"lastname": "Funayama"
},
{
"affiliation": "Division of Metabolism and Biosystemic Science, Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa, Japan.",
"collective": null,
"firstname": "Chihiro",
"initials": "C",
"lastname": "Sumi"
},
{
"affiliation": "Division of Metabolism and Biosystemic Science, Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa, Japan.",
"collective": null,
"firstname": "Takeshi",
"initials": "T",
"lastname": "Saito"
},
{
"affiliation": "Division of Metabolism and Biosystemic Science, Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa, Japan.",
"collective": null,
"firstname": "Yasumichi",
"initials": "Y",
"lastname": "Toki"
},
{
"affiliation": "Division of Metabolism and Biosystemic Science, Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa, Japan.",
"collective": null,
"firstname": "Mayumi",
"initials": "M",
"lastname": "Hatayama"
},
{
"affiliation": "Institute of Biomedical Research, Sapporo Higashi Tokushukai Hospital, Sapporo, Japan.",
"collective": null,
"firstname": "Yusuke",
"initials": "Y",
"lastname": "Ono"
},
{
"affiliation": "Department of Hematology/Oncology, Asahikawa Kosei Hospital, Asahikawa, Japan.",
"collective": null,
"firstname": "Kazuya",
"initials": "K",
"lastname": "Sato"
},
{
"affiliation": "Division of Metabolism and Biosystemic Science, Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa, Japan; Institute of Biomedical Research, Sapporo Higashi Tokushukai Hospital, Sapporo, Japan.",
"collective": null,
"firstname": "Yusuke",
"initials": "Y",
"lastname": "Mizukami"
},
{
"affiliation": "Division of Metabolism and Biosystemic Science, Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa, Japan.",
"collective": null,
"firstname": "Toshikatsu",
"initials": "T",
"lastname": "Okumura"
}
] |
Clinica chimica acta; international journal of clinical chemistry
| null |
37837907
|
Monitoring mutant KRAS in plasma cell-free DNA can predict disease progression in a patient with multiple myeloma: A case report.
| null | null | null | null | null | null |
null |
Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.
|
10.1097/RLU.0000000000005593
| null |
[] |
2025-01-08
|
A 70-year-old man experienced an epileptic seizure. Subsequent MRI performed on close examination revealed high signal in the left occipital cortex on fluid-attenuated inversion recovery. Gadolinium contrast indicated enhancement along the cortex. 11C-Methionine PET/CT scan, performed to differentiate from a brain tumor, showed high uptake mainly along the left occipital lobe cortex. Spinal fluid examination revealed Cryptococcus neoformans, leading to a diagnosis of Cryptococcus meningoencephalitis.
|
[
{
"affiliation": "From the Department of Radiology, Tokushima University Hospital, Tokushima, Japan.",
"collective": null,
"firstname": "Yoichi",
"initials": "Y",
"lastname": "Otomi"
},
{
"affiliation": "Department of Neurosurgery, Tokushima University Hospital, Tokushima, Japan.",
"collective": null,
"firstname": "Natsumi",
"initials": "N",
"lastname": "Teshima"
},
{
"affiliation": "Department of Community Medicine and Medical Science, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.",
"collective": null,
"firstname": "Takayoshi",
"initials": "T",
"lastname": "Shinya"
},
{
"affiliation": "From the Department of Radiology, Tokushima University Hospital, Tokushima, Japan.",
"collective": null,
"firstname": "Hideki",
"initials": "H",
"lastname": "Otsuka"
},
{
"affiliation": "From the Department of Radiology, Tokushima University Hospital, Tokushima, Japan.",
"collective": null,
"firstname": "Masafumi",
"initials": "M",
"lastname": "Harada"
}
] |
Clinical nuclear medicine
| null |
39774157
|
11C-Methionine PET/CT in Cryptococcus Meningoencephalitis.
| null | null | null | null | null | null |
null | null | null |
The clinical characteritics of ectopic molar pregnancy depend upon the site of the disease. It can be metastasized distantly in early stage. Digital subtraction angiography, colour ultrosound and laparotomy may play very important roles in the diagnosis of ectopic molar pregnancy. Regular chemotherapy and resection of drug-resistant focus are still the main methods of treatment.
|
[] |
2005-09-02
|
To summerize the experience in the diagnosis and treatment of ectopic molar pregnancy.
Clinical data of 3 cases of women with ectopic hydatidiform mole in Peking Union Medical College Hospital were analyzed retrospectively.
The clinical characteritics of ectopic molar pregnancy depend upon the site of the disease. It can be metastasized distantly in early stage. Digital subtraction angiography, colour ultrosound and laparotomy may play very important roles in the diagnosis of ectopic molar pregnancy. Regular chemotherapy and resection of drug-resistant focus are still the main methods of treatment.
Prophylactic chemotherapy for ectopic molar pregnancy should be emphasized. It is very important to make an early diagnosis of malignant metastasis and to give a regular treatment for the patients.
|
[
{
"affiliation": "Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.",
"collective": null,
"firstname": "S",
"initials": "S",
"lastname": "Ma"
},
{
"affiliation": null,
"collective": null,
"firstname": "Y",
"initials": "Y",
"lastname": "Xiang"
},
{
"affiliation": null,
"collective": null,
"firstname": "X",
"initials": "X",
"lastname": "Yang"
}
] |
Zhonghua fu chan ke za zhi
| null |
16134527
|
[Diagnosis and treatment of ectopic molar pregnancy].
| null | null | null | null | null | null |
null | null |
10.1080/15389588.2021.1980783
|
The literature shows that there is promising to strong evidence that alcohol monitoring is an effective component in treating DUI offenders and reducing recidivism rates. Alcohol ignition interlocks had the most studies (71 of the 131 articles identified in this review) and research shows that recidivism rates can be reduced by 50 to 90 percent for offenders while the interlock is installed. However, most ignition interlock studies are subject to sampling issues where participants are not randomly assigned to experimental and comparison groups. There is also evidence that alcohol monitoring is a key measure in 24/7 Sobriety Programs, in enforcing abstinence, and in overall alcohol treatment programs.
|
[
"Alcohol monitoring",
"driving-under-the-influence (DUI) offenders",
"literature review",
"transdermal alcohol concentration (TAC)"
] |
2021-10-22
|
The advent of continuous, passive, transdermal alcohol-monitoring devices and portable breath-testing devices with cameras provides a more efficient and reliable method for controlling the impaired driving of driving-under-the-influence (DUI) offenders. The objective of this study was to conduct a comprehensive literature review and synthesis of the strategies, the obstacles and the effectiveness of implementing alcohol monitoring as a component of treatment for DUI offenders.
A formalized review of the existing literature was conducted including both peer-reviewed and gray literature resources. Professional association websites were also searched in an effort to seek information on the effectiveness or ineffectiveness of alcohol monitoring as a strategy to treat DUI offenders. The review was guided by pre-defined inclusion/exclusion criteria that identified the scope and key terms to use when searching.
The literature shows that there is promising to strong evidence that alcohol monitoring is an effective component in treating DUI offenders and reducing recidivism rates. Alcohol ignition interlocks had the most studies (71 of the 131 articles identified in this review) and research shows that recidivism rates can be reduced by 50 to 90 percent for offenders while the interlock is installed. However, most ignition interlock studies are subject to sampling issues where participants are not randomly assigned to experimental and comparison groups. There is also evidence that alcohol monitoring is a key measure in 24/7 Sobriety Programs, in enforcing abstinence, and in overall alcohol treatment programs.
Transdermal monitoring is generally effective in deterring offenders from drinking alcohol. Offenders who drink or are otherwise noncompliant are likely to be identified. Transdermal monitoring helps enforce abstinence, which in turn helps offenders quit drinking and go into a recovery stage, potentially creating long-term safety benefits for the community. Continuous transdermal monitoring is a more effective means of monitoring drinking than other techniques and technologies (e.g., self-report, periodic or random breath tests, patches, or urinalysis).
|
[
{
"affiliation": "NORC at the University of Chicago, Bethesda, Maryland.",
"collective": null,
"firstname": "James C",
"initials": "JC",
"lastname": "Fell"
},
{
"affiliation": "NORC at the University of Chicago, Bethesda, Maryland.",
"collective": null,
"firstname": "Jennifer",
"initials": "J",
"lastname": "Scolese"
}
] |
Traffic injury prevention
|
A formalized review of the existing literature was conducted including both peer-reviewed and gray literature resources. Professional association websites were also searched in an effort to seek information on the effectiveness or ineffectiveness of alcohol monitoring as a strategy to treat DUI offenders. The review was guided by pre-defined inclusion/exclusion criteria that identified the scope and key terms to use when searching.
|
34672885
|
The effectiveness of alcohol monitoring as a treatment for driving-while-intoxicated (DWI) offenders: A literature review and synthesis.
| null | null | null | null | null | null |
null |
© 2024 Wiley Periodicals LLC.
|
10.1002/pbc.31307
|
Participating caregivers were primarily Black or African American (88.9%), mothers (81.5%), publicly insured (55.6%), and single (51.9%). Caregivers described medical decision-making across acute symptom response, preventive disease management, and treatment initiation and/or discontinuation. Across these contexts of disease management, caregivers overarchingly prioritized protecting and improving their child's quality of life. Caregivers' medical decision-making processes were influenced by their SCA management experience, acquisition of SCA knowledge, and trust in medical providers. The extent to which these influences impacted caregivers' decision-making varied based on disease severity, disease management experience, and time since diagnosis.
|
[
"childhood",
"decision‐making",
"parents/caregivers’ perspectives",
"qualitative methods",
"sickle cell anemia/disease"
] |
2024-09-20
|
Sickle cell disease (SCD) is the most common genetic disorder among children. As the most common type of SCD, sickle cell anemia (SCA) is associated with severe complications across the lifespan. As parents/caregivers hold primary disease management responsibility during childhood, their involvement in disease management activities, including medical decision-making, is critical to successful and timely management of pediatric SCD. However, the processes through which caregivers make SCD-related decisions remain unknown. The current paper examined caregivers' decision-making processes and priorities when managing their child's SCD.
Parents and primary caregivers (N = 27) of children with SCA (ages 0-12) completed individual semi-structured qualitative interviews exploring links between caregivers' decision-making and both daily and ongoing SCA management practices. Data were transcribed verbatim, cleaned, systematically coded, and analyzed using applied thematic analysis.
Participating caregivers were primarily Black or African American (88.9%), mothers (81.5%), publicly insured (55.6%), and single (51.9%). Caregivers described medical decision-making across acute symptom response, preventive disease management, and treatment initiation and/or discontinuation. Across these contexts of disease management, caregivers overarchingly prioritized protecting and improving their child's quality of life. Caregivers' medical decision-making processes were influenced by their SCA management experience, acquisition of SCA knowledge, and trust in medical providers. The extent to which these influences impacted caregivers' decision-making varied based on disease severity, disease management experience, and time since diagnosis.
Findings highlight how processes underlying caregivers' decision-making are directly influenced and informed by caregivers' lived experiences. Future work should develop provider-initiated collaborative interventions to support medical decision-making.
|
[
{
"affiliation": "Child and Family Health Lab, Department of Psychological and Brain Sciences, Boston University, Boston, Massachusetts, USA.",
"collective": null,
"firstname": "Ariel O",
"initials": "AO",
"lastname": "Blakey"
},
{
"affiliation": "Child and Family Health Lab, Department of Psychological and Brain Sciences, Boston University, Boston, Massachusetts, USA.\nNemours Children's Hospital, Delaware, Wilmington, Delaware, USA.",
"collective": null,
"firstname": "Christina M",
"initials": "CM",
"lastname": "Amaro"
},
{
"affiliation": "Child and Family Health Lab, Department of Psychological and Brain Sciences, Boston University, Boston, Massachusetts, USA.",
"collective": null,
"firstname": "Jenna Sandler",
"initials": "JS",
"lastname": "Eilenberg"
},
{
"affiliation": "Boston Medical Center, Boston, Massachusetts, USA.",
"collective": null,
"firstname": "Annelise",
"initials": "A",
"lastname": "Brochier"
},
{
"affiliation": "Boston Medical Center, Boston, Massachusetts, USA.\nDepartment of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.",
"collective": null,
"firstname": "Patricia L",
"initials": "PL",
"lastname": "Kavanagh"
},
{
"affiliation": "Child Health Equity Center, Department of Pediatrics, UMass Chan Medical School, UMass Memorial Children's Medical Center, Worcester, Massachusetts, USA.",
"collective": null,
"firstname": "Arvin",
"initials": "A",
"lastname": "Garg"
},
{
"affiliation": "Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.\nDepartment of Pediatrics, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.\nDepartment of Health Law, Policy & Management, Boston University School of Public Health, Boston, Massachusetts, USA.",
"collective": null,
"firstname": "Mari-Lynn",
"initials": "ML",
"lastname": "Drainoni"
},
{
"affiliation": "Child and Family Health Lab, Department of Psychological and Brain Sciences, Boston University, Boston, Massachusetts, USA.",
"collective": null,
"firstname": "Kristin",
"initials": "K",
"lastname": "Long"
}
] |
Pediatric blood & cancer
| null |
39302737
|
Characterizing medical decision-making in sickle cell disease during childhood: Qualitative perspectives of caregivers.
| null | null | null | null | null | null |
null | null | null | null |
[] |
2008-12-09
|
Southeast Asia is a region where the number of people infected with HIV/AIDS is one of the fastest growing in the world. Tuberculosis (TB) has grown along with the HIV epidemic. TB is not only the most common AIDS-defining illness but is also the leading cause of morbidity and mortality in AIDS patients. Cryptococcosis (meningitis or disseminated) is one of the most common opportunistic infections in AIDS patients. Cryptococcal meningitis is the first in the differential diagnosis considered with meningeal irritation. Penicillosis, a unique systemic mycosis, is an important emerging public health problem and has been classified as an AIDS defining illness in endemic areas like Thailand. Pneumocystis carinii (jiroveci) pneumonia has been one of the most important opportunistic infections in AIDS patients. Among parasitic infections, cryptosporidiosis is the most common intestinal protozoan infection relating to diarrhea in AIDS patients and toxoplasmosis is the only parasitic infection of the nervous system with a substantial incidence, up to 14.8%. Cytomegalovirus (CMV) retinitis has a lower prevalence compared to other opportunistic infections. In the era of highly active antiretroviral therapy (HAART), the incidence of opportunistic infections has significantly reduced in the past few years. Subsequently, the phenomena of immune restoration inflammatory syndrome (IRIS) in AIDS patients has been reported in this region as a result of HAART.
|
[
{
"affiliation": "Department of Parasitology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. [email protected]",
"collective": null,
"firstname": "Veeranoot",
"initials": "V",
"lastname": "Nissapatorn"
}
] |
The Southeast Asian journal of tropical medicine and public health
| null |
19058599
|
Lessons learned about opportunistic infections in southeast Asia.
| null | null | null | null | null | null |
null | null |
10.1016/s0039-6109(16)41136-9
| null |
[] |
1977-02-01
|
Most bullets which enter the body usually exit or lodge within the soft tissues having traveled in a straight line. Management of such patients is usually a simple matter of repairing the injuries incurred during the passage of the bullet. Emphasis must be placed on the initial management of the patient and his life-threatening injuries. Secondly, localization of the bullet should be done. Lastly, determination as to whether the bullet should be removed should be based on the hazards of its staying in its present position versus the hazards of its attempted removal.
|
[
{
"affiliation": null,
"collective": null,
"firstname": "A M",
"initials": "AM",
"lastname": "Ledgerwood"
}
] |
The Surgical clinics of North America
| null |
324004
|
The wandering bullet.
| null | null | null | null | null | null |
null |
© 2024 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
|
10.1002/alz.14162
| null |
[
"Alzheimer's Disease Neuroimaging Initiative",
"Alzheimer's disease",
"amyloid‐related imaging abnormalities monitoring",
"clinical neuroimaging",
"magnetic resonance imaging protocols",
"neuroimaging",
"patient screening"
] |
2024-08-08
|
Phase four of the Alzheimer's Disease Neuroimaging Initiative (ADNI4) magnetic resonance imaging (MRI) protocols aim to maintain longitudinal consistency across two decades of data acquisition, while adopting new technologies. Here we describe and justify the study's design and targeted biomarkers. The ADNI4 MRI protocol includes nine MRI sequences. Some sequences require the latest hardware and software system upgrades and are continuously rolled out as they become available at each site. The main sequence additions/changes in ADNI4 are: (1) compressed sensing (CS) T1-weighting, (2) pseudo-continuous arterial spin labeling (ASL) on all three vendors (GE, Siemens, Philips), (3) multiple-post-labeling-delay ASL, (4) 1 mm
|
[
{
"affiliation": "Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.",
"collective": null,
"firstname": "Arvin",
"initials": "A",
"lastname": "Arani"
},
{
"affiliation": "Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.",
"collective": null,
"firstname": "Bret",
"initials": "B",
"lastname": "Borowski"
},
{
"affiliation": "Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.",
"collective": null,
"firstname": "John",
"initials": "J",
"lastname": "Felmlee"
},
{
"affiliation": "Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.",
"collective": null,
"firstname": "Robert I",
"initials": "RI",
"lastname": "Reid"
},
{
"affiliation": "Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, University College London, London, UK.",
"collective": null,
"firstname": "David L",
"initials": "DL",
"lastname": "Thomas"
},
{
"affiliation": "Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.",
"collective": null,
"firstname": "Jeffrey L",
"initials": "JL",
"lastname": "Gunter"
},
{
"affiliation": "Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA.",
"collective": null,
"firstname": "Lara",
"initials": "L",
"lastname": "Stables"
},
{
"affiliation": "Department of Psychology, Center for Brain Science, Harvard University, Cambridge, Massachusetts, USA.",
"collective": null,
"firstname": "Randy L",
"initials": "RL",
"lastname": "Buckner"
},
{
"affiliation": "Department of Biomedical Engineering, University of California Davis, Davis, California, USA.",
"collective": null,
"firstname": "Youngkyoo",
"initials": "Y",
"lastname": "Jung"
},
{
"affiliation": "Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA.",
"collective": null,
"firstname": "Duygu",
"initials": "D",
"lastname": "Tosun"
},
{
"affiliation": "Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA.",
"collective": null,
"firstname": "Michael",
"initials": "M",
"lastname": "Weiner"
},
{
"affiliation": "Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.",
"collective": null,
"firstname": "Clifford R",
"initials": "CR",
"lastname": "Jack"
},
{
"affiliation": null,
"collective": null,
"firstname": null,
"initials": null,
"lastname": null
}
] |
Alzheimer's & dementia : the journal of the Alzheimer's Association
| null |
39115941
2374495
17969013
37201641
36449413
22818791
15334582
25044035
38247051
15906300
12111955
22484410
23587694
30837858
31075422
|
Design and validation of the ADNI MR protocol.
| null | null | null | null | null | null |
null | null |
10.53854/liim-3203-15
| null |
[
"Milan’s plague epidemic",
"Yersinia pestis",
"bubonic plague",
"hidden cases"
] |
2024-09-17
|
In the summer of 1630, Milan experienced the most devastating plague epidemic in its history. In this study, addressed to investigate the earliest phases of the epidemic in the autumn of 1629, a set of unpublished and only partially known primary sources produced by the city's Officium Sanitatis was consulted and compared for the first time. Including those of two foreigners who died in the Lazzaretto, it was possible to ascertain a total of 39 cases of plague occurred in Milan between 9 October 1629 and the first weeks of 1630, of which 29 (74.4%) ended in death. Seven deaths presumably occurred at home were not recorded in the Liber Mortuorum, in which at least three other deaths caused by plague were deliberately attributed to a different cause. In particular, the case of the Vicario di Provisione in charge, Alfonso Visconti, probably the first death from plague occurred in Milan that year, was deliberately concealed for political reasons. Nevertheless, the spread of the disease remained limited in autumn 1629 and it was probably stopped until the following spring more by climatic factors than by the interventions of public health officials.
|
[
{
"affiliation": "Department of Pharmacological and Biomolecular Sciences, University of Milan, Italy.\nRomeo and Enrica Invernizzi National Institute of Molecular Genetics (INGM), Milan, Italy.",
"collective": null,
"firstname": "Riccardo",
"initials": "R",
"lastname": "Nodari"
},
{
"affiliation": "Department of the Humanities, Section of Historical and Geographical Science, University of Pavia, Italy.",
"collective": null,
"firstname": "Luca",
"initials": "L",
"lastname": "Fois"
},
{
"affiliation": "Department of Biomedical and Clinical Sciences, University of Milan, Italy.",
"collective": null,
"firstname": "Ester",
"initials": "E",
"lastname": "Luconi"
},
{
"affiliation": "Department of Historical Studies, University of Milan, Italy.",
"collective": null,
"firstname": "Folco",
"initials": "F",
"lastname": "Vaglienti"
},
{
"affiliation": "Department of Biomedical and Clinical Sciences, Pediatric Clinical Research Center \"Romeo and Enrica Invernizzi\", University of Milan, Italy.",
"collective": null,
"firstname": "Francesco",
"initials": "F",
"lastname": "Comandatore"
},
{
"affiliation": "Department of Biomedical and Clinical Sciences, University of Milan, Italy.",
"collective": null,
"firstname": "Massimo",
"initials": "M",
"lastname": "Galli"
}
] |
Le infezioni in medicina
| null |
39282547
|
Unveiling Milan's hidden cases of plague occurred in autumn 1629, before the great 1630 epidemic.
| null | null | null | null | null | null |
null | null |
10.1097/00007611-199408000-00009
| null |
[] |
1994-08-01
|
We report a case of Haemophilus paraphrophilus causing primary liver abscesses after blunt nonpenetrating trauma. A 32-year-old previously healthy white man sustained a back injury 2 months prior to admission with fever, chills, and night sweats. A computed tomography (CT) scan-directed needle aspirate of several hypoechoic hepatic lesions grew H paraphrophilus. Recent blunt trauma to the lower back may have contributed to the localization of this infection to an area of contusion or hematoma within the liver, followed by an episode of bacteremia that seeded the injury.
|
[
{
"affiliation": "Department of Medicine, University of South Florida College of Medicine, Tampa.",
"collective": null,
"firstname": "D O",
"initials": "DO",
"lastname": "Haight"
},
{
"affiliation": null,
"collective": null,
"firstname": "J F",
"initials": "JF",
"lastname": "Toney"
},
{
"affiliation": null,
"collective": null,
"firstname": "J N",
"initials": "JN",
"lastname": "Greene"
},
{
"affiliation": null,
"collective": null,
"firstname": "R L",
"initials": "RL",
"lastname": "Sandin"
},
{
"affiliation": null,
"collective": null,
"firstname": "A L",
"initials": "AL",
"lastname": "Vincent"
}
] |
Southern medical journal
| null |
8052889
|
Liver abscess following blunt trauma: a case report and review of the literature.
| null | null | null | null | null | null |
Recently there have been some reports of endoscopic ampullectomy for small carcinoid tumors. However, this case suggests that attention should be paid to the possibility of lymph node metastases as well as that of regional infiltration of the tumor even for minute ampullary carcinoid tumors to provide the best chance for cure.
| null |
10.1186/1477-7819-7-9
10.1097/01.mcg.0000225651.00308.79
10.1111/j.1440-1746.2005.03744.x
10.1002/1097-0142(19940315)73:6<1580::AID-CNCR2820730608>3.0.CO;2-0
10.1007/s11605-007-0389-3
10.1007/s11605-007-0240-x
10.1016/S1091-255X(03)00114-8
10.1002/1097-0142(19930201)71:3<686::AID-CNCR2820710306>3.0.CO;2-Z
| null |
[] |
2009-01-23
|
Carcinoid tumors are usually considered to have a low degree of malignancy and show slow progression. One of the factors indicating the malignancy of these tumors is their size, and small ampullary carcinoid tumors have been sometimes treated by endoscopic resection.
We report a case of a 63-year-old woman with a minute ampullary carcinoid tumor that was 7 mm in diameter, but was associated with 2 peripancreatic lymph node metastases. Mild elevation of liver enzymes was found at her regular medical check-up. Computed tomography (CT) revealed a markedly dilated common bile duct (CBD) and two enlarged peripancreatic lymph nodes. Endoscopy showed that the ampulla was slightly enlarged by a submucosal tumor. The biopsy specimen revealed tumor cells that showed monotonous proliferation suggestive of a carcinoid tumor. She underwent a pylorus-preserving whipple resection with lymph node dissection. The resected lesion was a small submucosal tumor (7 mm in diameter) at the ampulla, with metastasis to 2 peripancreatic lymph nodes, and it was diagnosed as a malignant carcinoid tumor.
Recently there have been some reports of endoscopic ampullectomy for small carcinoid tumors. However, this case suggests that attention should be paid to the possibility of lymph node metastases as well as that of regional infiltration of the tumor even for minute ampullary carcinoid tumors to provide the best chance for cure.
|
[
{
"affiliation": "Department of Gastroenterology and Hepatology, Shinko Hospital, Kobe, Hyogo, Japan. [email protected]",
"collective": null,
"firstname": "Eri",
"initials": "E",
"lastname": "Senda"
},
{
"affiliation": null,
"collective": null,
"firstname": "Koji",
"initials": "K",
"lastname": "Fujimoto"
},
{
"affiliation": null,
"collective": null,
"firstname": "Katsuhiro",
"initials": "K",
"lastname": "Ohnishi"
},
{
"affiliation": null,
"collective": null,
"firstname": "Akihiro",
"initials": "A",
"lastname": "Higashida"
},
{
"affiliation": null,
"collective": null,
"firstname": "Cho",
"initials": "C",
"lastname": "Ashida"
},
{
"affiliation": null,
"collective": null,
"firstname": "Toshio",
"initials": "T",
"lastname": "Okutani"
},
{
"affiliation": null,
"collective": null,
"firstname": "Shigeru",
"initials": "S",
"lastname": "Sakano"
},
{
"affiliation": null,
"collective": null,
"firstname": "Masayuki",
"initials": "M",
"lastname": "Yamamoto"
},
{
"affiliation": null,
"collective": null,
"firstname": "Rieko",
"initials": "R",
"lastname": "Ito"
},
{
"affiliation": null,
"collective": null,
"firstname": "Hajime",
"initials": "H",
"lastname": "Yamada"
}
] |
World journal of surgical oncology
| null |
19159493
15683115
17451212
17667049
15853978
10917194
8156484
17992565
17674113
13129555
8094317
|
Minute ampullary carcinoid tumor with lymph node metastases: a case report and review of literature.
| null | null | null | null | null | null |
null |
Copyright © 2020 Elsevier Inc. All rights reserved.
|
10.1016/j.fsc.2020.08.005
| null |
[
"Dorsal aesthetic lines",
"Hump resection",
"Internal nasal valve",
"Keystone area",
"Ligaments of the nose",
"Nasal dorsum",
"Preservation rhinoplasty",
"Upper lateral cartilage"
] |
2020-11-23
|
Preservation rhinoplasty may refer to preserving several anatomic components including: the nasal bones, upper lateral cartilages, the keystone area and/or ligaments of the nose. Preserving the osseocartilaginous framework or "dorsal preservation" minimizes or completely avoids violation of the dorsal aesthetic lines' architecture. Conventional hump reduction in open rhinoplasty disrupts these lines; however, it also provides versatility to reshape the entire dorsum. Surgical success with either technique requires a thorough understanding of the underlying nasal anatomy.
|
[
{
"affiliation": "Department of Otolaryngology-Head & Neck Surgery, Mansoura University, Faculty of Medicine, Gomhoreya Street, Mansoura 35516, Egypt. Electronic address: [email protected].",
"collective": null,
"firstname": "Mohamed",
"initials": "M",
"lastname": "Abdelwahab"
},
{
"affiliation": "Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.",
"collective": null,
"firstname": "Priyesh N",
"initials": "PN",
"lastname": "Patel"
}
] |
Facial plastic surgery clinics of North America
| null |
33220840
|
Conventional Resection Versus Preservation of the Nasal Dorsum and Ligaments: An Anatomic Perspective and Review of the Literature.
| null | null | null | null | null | null |
null |
Copyright © 2023 American Brachytherapy Society. All rights reserved.
|
10.1016/j.brachy.2023.04.006
|
In Phase 1, there was a significantly higher median pain score (p < 0.001) and more episodes with unacceptable pain scores (46%) in the IV-PCA group compared with either epidural modality (6-14%; p < 0.001). In Phase 2, we observed a greater median pain score (p = 0.007) and higher proportion of patient episodes with unacceptable pain scores (38%) in the CEI group compared with both the IV-PCA (13%) and PIEB-PCEA (14%) groups (p = 0.001). There was a significant difference in median OMED used throughout all phases across the PIEB-PCEA (0 mg), IV-PCA (70 mg), and CEI (15 mg) groups (p < 0.001).
|
[
"Cervical cancer",
"Epidural analgesia",
"Intrauterine brachytherapy",
"Operative analgesia"
] |
2023-07-10
|
Effective periprocedural analgesia is an important aspect of cervical brachytherapy delivery, with implications for patient comfort and attendance for subsequent fractions. We compared the efficacy and safety of three analgesic modalities: intravenous patient-controlled analgesia (IV-PCA), continuous epidural infusion (CEI) and programmed-intermittent epidural bolus with patient-controlled epidural analgesia (PIEB-PCEA).
Ninety-seven brachytherapy episodes involving 36 patients between July 2016 and June 2019 in a single tertiary center were retrospectively reviewed. Episodes were divided into two key phases: Phase 1 (while applicator remained in situ) and Phase 2 (following applicator removal until discharge or 4 h). For the primary endpoint, pain scores were retrieved and analyzed by analgesic modality with respect to median score and an internally defined "unacceptable" pain experience (>20% of scores being ≥4/10; i.e., moderate or greater). Total nonepidural oral morphine equivalent dose (OMED) and toxicity/complication events were reported as secondary endpoints.
In Phase 1, there was a significantly higher median pain score (p < 0.001) and more episodes with unacceptable pain scores (46%) in the IV-PCA group compared with either epidural modality (6-14%; p < 0.001). In Phase 2, we observed a greater median pain score (p = 0.007) and higher proportion of patient episodes with unacceptable pain scores (38%) in the CEI group compared with both the IV-PCA (13%) and PIEB-PCEA (14%) groups (p = 0.001). There was a significant difference in median OMED used throughout all phases across the PIEB-PCEA (0 mg), IV-PCA (70 mg), and CEI (15 mg) groups (p < 0.001).
PIEB-PCEA is safe and offers superior analgesia compared to IV-PCA or CEI for pain control after applicator placement in cervical brachytherapy.
|
[
{
"affiliation": "Department of Anaesthesia, Royal Hospital for Women, Randwick, NSW, Australia; Nepean Hospital, Kingswood, NSW, Australia.",
"collective": null,
"firstname": "Nicholas",
"initials": "N",
"lastname": "Chee"
},
{
"affiliation": "Department of Anaesthesia, Royal Hospital for Women, Randwick, NSW, Australia.",
"collective": null,
"firstname": "Alyson",
"initials": "A",
"lastname": "McGrath"
},
{
"affiliation": "Department of Radiation Oncology, Prince of Wales Hospital, Randwick, NSW, Australia; Prince of Wales Clinical School, Faculty of Medicine & Health, UNSW, Sydney, NSW, Australia.",
"collective": null,
"firstname": "Stephen R",
"initials": "SR",
"lastname": "Thompson"
},
{
"affiliation": "Department of Radiation Oncology, Prince of Wales Hospital, Randwick, NSW, Australia; St George and Sutherland Clinical School, Faculty of Medicine & Health, UNSW, Sydney, NSW, Australia.",
"collective": null,
"firstname": "Matthew C",
"initials": "MC",
"lastname": "Knox"
},
{
"affiliation": "Department of Anaesthesia, Royal Hospital for Women, Randwick, NSW, Australia.",
"collective": null,
"firstname": "Luca",
"initials": "L",
"lastname": "Marengo"
},
{
"affiliation": "Department of Radiation Oncology, Prince of Wales Hospital, Randwick, NSW, Australia; Prince of Wales Clinical School, Faculty of Medicine & Health, UNSW, Sydney, NSW, Australia.",
"collective": null,
"firstname": "Michael",
"initials": "M",
"lastname": "Jackson"
},
{
"affiliation": "Department of Anaesthesia, Royal Hospital for Women, Randwick, NSW, Australia.",
"collective": null,
"firstname": "John-Paul",
"initials": "JP",
"lastname": "Favero"
},
{
"affiliation": "Department of Anaesthesia, Royal Hospital for Women, Randwick, NSW, Australia. Electronic address: [email protected].",
"collective": null,
"firstname": "Leonie",
"initials": "L",
"lastname": "Watterson"
}
] |
Brachytherapy
| null |
37423807
|
Comparison of three analgesic regimens in women undergoing cervical brachytherapy.
| null | null | null | null | null | null |
null | null |
10.11152/mu-3209
|
The distribution of the Fallopian tubes corresponded to the positions of the ipsilateral ovaries in the superoinferior direction (χ2 =197.653, p<0.001), mediolateral direction (χ2 =237.447, p <0.001) and anteroposterior direction (χ2 =109.746, p<0.001). Tubal morphology differed according to ovarian position in the superoinferior (χ2 =21.804, p<0.001), mediolateral directions (χ2 =4.679, p=0.031) but not in the anteroposterior direction (χ2 =0.793, p=0.373).
|
[] |
2021-09-12
|
To investigate the positional relationship between the ovary and Fallopian tube and the relationship between the ovarian position and tubal morphology.
A total of 195 patients with 338 fallopian tubes were enrolled in this retrospective study. The ovarian and tubal positions were defined relative to the uterus in all directions. Tubal morphology was classified as smooth or tortuous.
The distribution of the Fallopian tubes corresponded to the positions of the ipsilateral ovaries in the superoinferior direction (χ2 =197.653, p<0.001), mediolateral direction (χ2 =237.447, p <0.001) and anteroposterior direction (χ2 =109.746, p<0.001). Tubal morphology differed according to ovarian position in the superoinferior (χ2 =21.804, p<0.001), mediolateral directions (χ2 =4.679, p=0.031) but not in the anteroposterior direction (χ2 =0.793, p=0.373).
Evaluating the ovarian position can provide preliminary information on the distribution and shapeof the Fallopian tube, helping the operator choose the appropriate initial plane and the necessary approaches for inspection.
|
[
{
"affiliation": "Department of Ultrasonography, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. [email protected].",
"collective": null,
"firstname": "Wu-Wu",
"initials": "WW",
"lastname": "Zheng"
},
{
"affiliation": "Department of Ultrasonography, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. [email protected].",
"collective": null,
"firstname": "Lixia",
"initials": "L",
"lastname": "Chen"
},
{
"affiliation": "Department of Ultrasonography, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. [email protected].",
"collective": null,
"firstname": "Shunping",
"initials": "S",
"lastname": "Chen"
},
{
"affiliation": "Department of Ultrasonography, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. [email protected].",
"collective": null,
"firstname": "Jian",
"initials": "J",
"lastname": "Zhu"
},
{
"affiliation": "Department of Gynecology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. [email protected].",
"collective": null,
"firstname": "Feng",
"initials": "F",
"lastname": "Lin"
},
{
"affiliation": "Department of Ultrasonography, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. [email protected].",
"collective": null,
"firstname": "Shihao",
"initials": "S",
"lastname": "Xu"
}
] |
Medical ultrasonography
| null |
34508616
|
Value of ovarian positional assessment on 4D hysterosalpingo-contrast sonography.
| null | null | null | null | null | null |
null |
© 2017 American Academy of Pain Medicine. All rights reserved. For permissions, please e-mail: [email protected].
|
10.1093/pm/pnw141
| null |
[
"Facet Joint",
"Fluoroscopy",
"Synovial Cyst",
"Zygoapophyseal Joint"
] |
2017-04-11
|
Synovial cysts of the lumbar zygapophysial joints can be treated by percutaneous injection of corticosteroids, with distension and rupture of the cyst. Some cysts can be difficult to access, particularly when they lie deep in relation to the lamina. This technical report describes a fluoroscopy-guided technique for accessing sublaminar pathology. Crucial to the safety of the technique is visualization of the ventral margin of the lamina using a contralateral oblique view, and controlling and limiting the insertion of the needle such that only its tip passes the lamina.
|
[
{
"affiliation": "Department of Rehabilitation Medicine, Mount Sinai Hospital, New York, NY, USA.",
"collective": null,
"firstname": "David",
"initials": "D",
"lastname": "Spinner"
},
{
"affiliation": "Department of Anesthesiology, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.",
"collective": null,
"firstname": "Moris",
"initials": "M",
"lastname": "Aner"
},
{
"affiliation": "Department of Rehabilitation Medicine, Mount Sinai Hospital, New York, NY, USA.",
"collective": null,
"firstname": "Geet",
"initials": "G",
"lastname": "Paul"
},
{
"affiliation": "Department of Anesthesiology, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.",
"collective": null,
"firstname": "Thomas",
"initials": "T",
"lastname": "Simopoulos"
},
{
"affiliation": "Department of Anesthesiology, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.",
"collective": null,
"firstname": "Jatinder",
"initials": "J",
"lastname": "Gill"
}
] |
Pain medicine (Malden, Mass.)
| null |
28395102
|
Percutaneous Translaminar Facet Cyst Rupture and Epidural Access-Description of a Novel Technique.
| null | null | null | null | null | null |
null | null |
10.1055/s-2008-1066086
| null |
[] |
1994-06-01
|
Of 450 children examined for front chest wall malformations, 210 underwent a corrective operation: 190 funnel chests and 20 pigeon chests. A classification of the anatomic forms is presented which contains 6 groups: vertical cup-shaped (the most common), horizontal cup-shaped, vallecular, mixed, complex with sternal torsion or polymalformations. The operation has been programmed in 64% of the cases between 10 and 18 years, but 36% were operated under 6 years because of a severe functional disturbance. On the technical side, Ravitch's procedure is still used on young infants; for the other cases sternochondro-plasty is to be preferred. The fixation of the chest wall is realized with an original, light, solid elastic material taking little space, and easy to remove. This material is presented. The immediate results: 62% very good, 35% good and 3% mediocre, sometimes do present a pejorative evolution, so that after two years of follow-up we notice: 55% remained perfect, 35% very good, 10% moderate of which, 4% to be reoperated. This deterioration touches more particularly the older children operated between 16 and 18 years. Among the children between 3 and 6 years the results are usually very good and remain stable with growth.
|
[
{
"affiliation": "Clinique Chirurgicale Pédiatrique, Hôpital d'Enfants de Nancy, Vandoeuvre-Nancy, France.",
"collective": null,
"firstname": "J",
"initials": "J",
"lastname": "Prévot"
}
] |
European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie
| null |
8086387
|
Treatment of sternocostal wall malformations of the child. A series of 210 surgical corrections since 1975.
| null | null | null | null | null | null |
null | null |
10.1177/106689690100900108
| null |
[] |
2001-07-27
|
Five cases of renal cell carcinoma metastatic to the testis or its adnexa are described, including 3 that represented the initial presentation and mimicked primary testicular neoplasms. The patients ranged from 46 to 85 years of age. Three presented with self-identified testicular masses. One patient was investigated because of fever of unknown origin and was found to have a left rib metastasis. Further work-up led to the discovery of a testicular mass. The final patient had a tumor of the spermatic cord that was examined without knowledge that he had a prior renal neoplasm. All the tumors were unilateral. They ranged from 1.8 to 5.0 cm; multiple tumor nodules were present in one of them but the others were discrete solitary masses. Four tumors were yellow/yellow-tan, and one was gray. On microscopic examination all the tumors were of the clear cell type. Patterns included solid sheets, acini, cysts, alveoli, and trabeculae. Two had prominent vascular invasion. Diagnoses initially entertained in these cases included Sertoli cell tumor, Sertoli-Leydig cell tumor, and clear cell cystadenoma of the epididymis. In 3 cases a kidney tumor was discovered 2 to 4 weeks after the diagnosis of renal cell carcinoma metastatic to the testis was rendered. On follow-up two patients died of tumor, and two were alive (5 months and 1 year) after orchiectomy. The diagnosis of renal cell carcinoma metastatic to the testis should be considered in evaluating a clear cell tumor of the testis, particularly in an older male or if the appearance suggests a Sertoli cell tumor. The differences in survival between metastatic renal cell carcinoma and sex cord-stromal tumors indicate the importance of considering the former in the differential.
|
[
{
"affiliation": "Department of Pathology, Froedtert Memorial Lutheran Hospital and Medical College of Wisconsin, Milwaukee 53226-0509, USA.",
"collective": null,
"firstname": "M W",
"initials": "MW",
"lastname": "Datta"
},
{
"affiliation": null,
"collective": null,
"firstname": "T M",
"initials": "TM",
"lastname": "Ulbright"
},
{
"affiliation": null,
"collective": null,
"firstname": "R H",
"initials": "RH",
"lastname": "Young"
}
] |
International journal of surgical pathology
| null |
11469344
|
Renal cell carcinoma metastatic to the testis and its adnexa: a report of five cases including three that accounted for the initial clinical presentation.
| null | null | null | null | null | null |
null |
Copyright © 2016 American Society for Surgery of the Hand. Published by Elsevier Inc. All rights reserved.
|
10.1016/j.jhsa.2016.08.003
|
After an average of 26 months, M3 recovery of thumb and finger extension was observed in the 3 upper limbs from the 2 youngest patients who underwent a nerve transfer. None of the free gracilis-treated patients achieved scores above M2.
|
[
"Nerve transfer",
"free muscle transfer",
"spinal cord injury",
"tetraplegia"
] |
2016-09-07
|
With spinal cord injuries, muscles below the level of the lesion remain innervated despite the absence of volitional control. This persistent innervation protects against denervation atrophy and may allow for nerve transfers to treat long-standing lesions within the spinal cord. We tested the hypothesis that in chronic spinal cord lesions, muscles remained viable for reinnervation.
To test this hypothesis, we operated on 7 patients with tetraplegia to reconstruct thumb and finger extension after a mean interval of 5 years since injury. During surgery, if electrical stimulation of the posterior interosseous nerve (PIN) produced muscle contraction, the nerve to the supinator (NS) was transferred to the PIN. If no contractions were demonstrated, the muscles of the extensor compartment of the forearm were replaced via a free gracilis transfer with innervation supplied by the NS.
After an average of 26 months, M3 recovery of thumb and finger extension was observed in the 3 upper limbs from the 2 youngest patients who underwent a nerve transfer. None of the free gracilis-treated patients achieved scores above M2.
In our youngest patients aged 27 and 34 years, who were operated on 6 years after spinal cord injury, transfer of the NS to the PIN partially restored hand span.
Therapeutic V.
|
[
{
"affiliation": "Center of Biological and Health Sciences, Department of Neurosurgery, University of the South of Santa Catarina (Unisul), Tubarão, Santa Catarina, Brazil; Department of Orthopedic Surgery, Governador Celso Ramos Hospital, Florianópolis, Santa Catarina, Brazil. Electronic address: [email protected].",
"collective": null,
"firstname": "Jayme Augusto",
"initials": "JA",
"lastname": "Bertelli"
},
{
"affiliation": "Center of Biological and Health Sciences, Department of Neurosurgery, University of the South of Santa Catarina (Unisul), Tubarão, Santa Catarina, Brazil.",
"collective": null,
"firstname": "Marcos Flávio",
"initials": "MF",
"lastname": "Ghizoni"
}
] |
The Journal of hand surgery
| null |
27593485
|
Nerve and Free Gracilis Muscle Transfers for Thumb and Finger Extension Reconstruction in Long-standing Tetraplegia.
| null | null | null | null | null | null |
null |
Copyright: © 2023 Brain Circulation.
|
10.4103/bc.bc_64_22
| null |
[
"Carotid cavernous fistula",
"embolization",
"ophthalmoplegia"
] |
2023-05-08
|
Carotid cavernous fistulas (CCFs) are a rare but debilitating entity that may present with orbital or cerebral venous hypertension. CCFs may pose diagnostic and management pitfalls for clinicians as they can initially be misdiagnosed as primary orbital pathology or nonarteriovenous shunting-related cavernous sinus pathology. Furthermore, the resolution of pulsatile tinnitus could be an ominous sign in patients with untreated dural arteriovenous fistula. We describe a case of a 56-year-old male who presented with progressive right eye proptosis, congestion, decreased visual acuity, limited duction, exophthalmos, and pulsatile tinnitus. The patient had poor response to antibiotics and steroids. Magnetic resonance imaging brain showed significant inflammation involving the right orbit and atypical enhancement of the basal frontal lobe adjacent to the orbit. Cerebral angiography revealed an indirect right CCF and right sigmoid sinus thrombosis with stenosis of the right internal jugular vein. No clear predisposing factor was identified. Given the rapidly progressive nature of the condition, the patient successfully underwent endovascular treatment with transvenous approach to preserve flow in the internal carotid artery while ensuring occlusion of the fistula. A triad of proptosis, eye congestion, and signs of turbulent flow such as tinnitus or orbital bruit should raise suspicion for CCF. An interesting feature in this patient is that CCF may have occurred secondary to sigmoid sinus thrombosis with accompanying small cortical vein drainage. Our case highlights the importance of early recognition and timely intervention to ensure the resolution of orbital hypertension-related symptoms in rare cases of CCFs.
|
[
{
"affiliation": "Department of Neurology, University of Connecticut, Farmington, CT, USA.",
"collective": null,
"firstname": "Neeharika",
"initials": "N",
"lastname": "Krothapalli"
},
{
"affiliation": "Department of Interventional Neuroradiology, Hartford Hospital, Hartford, CT, USA.",
"collective": null,
"firstname": "Mohamad",
"initials": "M",
"lastname": "Fayad"
},
{
"affiliation": "Department of Neurosurgery, Hartford Hospital, Hartford, CT, USA.",
"collective": null,
"firstname": "Eric",
"initials": "E",
"lastname": "Sussman"
},
{
"affiliation": "Department of Interventional Neuroradiology, Hartford Hospital, Hartford, CT, USA.",
"collective": null,
"firstname": "Charles",
"initials": "C",
"lastname": "Bruno"
},
{
"affiliation": "Department of Interventional Neuroradiology, Hartford Hospital, Hartford, CT, USA.",
"collective": null,
"firstname": "Martin",
"initials": "M",
"lastname": "Ollenschleger"
},
{
"affiliation": "Department of Interventional Neuroradiology, Hartford Hospital, Hartford, CT, USA.",
"collective": null,
"firstname": "Tapan",
"initials": "T",
"lastname": "Mehta"
}
] |
Brain circulation
| null |
37151792
|
Carotid cavernous fistula: A rare but treatable cause of ophthalmoplegia - A case report.
| null | null | null | null | null | null |
Based on patient-specific dosimetry, the administered activity may be increased by an average factor of 2.4, indicating that most patients could be undertreated. The relative dosimetry approach based on planar imaging largely underestimates doses relative to reference values. Dosimetry based on planar bremsstrahlung imaging is not a dependable alternative to (111)In dosimetry.
| null |
10.1007/s00259-011-2040-5
|
The estimated red marrow absorbed doses from (111)In and (90)Y data were equivalent. In all cases, the doses absorbed by organs at risk were found to be within prescribed limits. The relative dosimetry approach applied to both the (90)Y and (111)In data significantly underestimated the doses relative to those obtained with the (111)In absolute dosimetry method which is generally accepted as the reference method (MIRD 16). In the case of (111)In, the relative dosimetry approach values were highly correlated (R(2) = 0.61) with the reference method values. Relative dosimetry estimates may be adjusted multiplying by a correction factor of 2.8. The (90)Y-ibritumomab tiuxetan relative dosimetry data correlated poorly with the reference method values (R (2) = 0.02).
|
[] |
2012-01-13
|
Radioimmunotherapy with (90)Y-ibritumomab tiuxetan has been used successfully used in the treatment of CD20-positive non-Hodgkin's lymphoma (NHL). Pretherapy imaging with (111)In-ibritumomab tiuxetan has been used in provisional dosimetry studies. Posttherapy imaging of (90)Y-ibritumomab tiuxetan for clinical use is appealing as it would simplify the data acquisition process and allow measurements of actual doses absorbed during treatment.
The study included 29 patients with non-Hodgkin's lymphoma, of whom 16 (group I) received a pretherapy (111)In-ibritumomab tiuxetan diagnostic study and (90)Y-ibritumomab tiuxetan treatment 1 week later, and 13 (group II) received only (90)Y-ibritumomab tiuxetan treatment. Planar imaging and blood sampling were performed in all patients. The doses absorbed by organs at risk were calculated using a whole-body average attenuation correction factor (relative dosimetry approach) and, in the case of the (111)In-ibritumomab tiuxetan image sets, also using organ-specific attenuation correction factors (absolute dosimetry method). Red marrow absorbed doses were based on gamma counting of blood samples.
The estimated red marrow absorbed doses from (111)In and (90)Y data were equivalent. In all cases, the doses absorbed by organs at risk were found to be within prescribed limits. The relative dosimetry approach applied to both the (90)Y and (111)In data significantly underestimated the doses relative to those obtained with the (111)In absolute dosimetry method which is generally accepted as the reference method (MIRD 16). In the case of (111)In, the relative dosimetry approach values were highly correlated (R(2) = 0.61) with the reference method values. Relative dosimetry estimates may be adjusted multiplying by a correction factor of 2.8. The (90)Y-ibritumomab tiuxetan relative dosimetry data correlated poorly with the reference method values (R (2) = 0.02).
Based on patient-specific dosimetry, the administered activity may be increased by an average factor of 2.4, indicating that most patients could be undertreated. The relative dosimetry approach based on planar imaging largely underestimates doses relative to reference values. Dosimetry based on planar bremsstrahlung imaging is not a dependable alternative to (111)In dosimetry.
|
[
{
"affiliation": "Nuclear Medicine Department, Istituto Nazionale per lo Studio e la Cura dei Tumori, Fondazione G Pascale, Napoli, Italy. [email protected]",
"collective": null,
"firstname": "C",
"initials": "C",
"lastname": "Arrichiello"
},
{
"affiliation": null,
"collective": null,
"firstname": "L",
"initials": "L",
"lastname": "Aloj"
},
{
"affiliation": null,
"collective": null,
"firstname": "M",
"initials": "M",
"lastname": "Mormile"
},
{
"affiliation": null,
"collective": null,
"firstname": "L",
"initials": "L",
"lastname": "D'Ambrosio"
},
{
"affiliation": null,
"collective": null,
"firstname": "F",
"initials": "F",
"lastname": "Frigeri"
},
{
"affiliation": null,
"collective": null,
"firstname": "C",
"initials": "C",
"lastname": "Caracò"
},
{
"affiliation": null,
"collective": null,
"firstname": "M",
"initials": "M",
"lastname": "Arcamone"
},
{
"affiliation": null,
"collective": null,
"firstname": "F",
"initials": "F",
"lastname": "De Martinis"
},
{
"affiliation": null,
"collective": null,
"firstname": "A",
"initials": "A",
"lastname": "Pinto"
},
{
"affiliation": null,
"collective": null,
"firstname": "S",
"initials": "S",
"lastname": "Lastoria"
}
] |
European journal of nuclear medicine and molecular imaging
| null |
22237846
|
Feasibility of bremsstrahlung dosimetry for direct dose estimation in patients undergoing treatment with 90Y-ibritumomab tiuxetan.
| null | null | null | null | null | null |
null | null | null | null |
[] |
1980-12-01
|
1. Bovine kidney pyruvate dehydrogenase multienzyme complex is inactivated by elastase in a similar manner as described earlier for papain. The core component, lipoate acetyltransferase, is cleaved by elastase into an active fragment (Mr 26000) and a fragment with apparent Mr of 45000 as analyzed by dodecylsulfate gel electrophoresis. Due to the fragmentation of the core, the enzyme complex is disassembled into its component enzymes which retain their complete enzymatic activities as assayed separately. 2. A different mechanism was found for the inactivation of pyruvate dehydrogenase complex with trypsin and some other proteases (chymotrypsin, clostripain). In these cases, the pyruvate dehydrogenase component is inactivated rapidly by limited proteolysis. More slowly, the enzyme complex is disassembled simultaneously with fragmentation of the lipoate acetyltransferase which again results in an active fragment of Mr 26000 and another fragment of apparent Mr 45000. Upon prolonged proteolysis, the latter fragment is cleaved further to give products of Mr 36000 or lower. 3. The enzyme-bound lipoyl residues of the pyruvate dehydrogenase complex have been labelled covalently by incubation with [2-14C]pyruvate. After treatment of this [14C]acetyl-enzyme with papain, elastase, or trypsin, radioactivity was associated exclusively with the 45000-Mr and 36000-Mr fragments but not with the active 26000-Mr fragment. 4. It is concluded that the bovine kidney lipoate acetyltransferase core is composed of 60 subunits each consisting of two dissimilar folding domains. One of these contains the intersubunit binding sites as well as the active center for transacylation whereas the other possesses the enzyme-bound lipoyl residues.
|
[
{
"affiliation": null,
"collective": null,
"firstname": "G B",
"initials": "GB",
"lastname": "Kresze"
},
{
"affiliation": null,
"collective": null,
"firstname": "H",
"initials": "H",
"lastname": "Ronft"
}
] |
European journal of biochemistry
| null |
6780350
|
Bovine kidney pyruvate dehydrogenase complex. Limited proteolysis and molecular structure of the lipoate acetyltransferase component.
| null | null | null | null | null | null |
null |
Copyright © 2024 Noe Juvenal Mendoza-Ramírez et al.
|
10.1155/2024/9313267
10.1038/s41586-020-2012-7
10.1016/j.chom.2020.02.001
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10.1007/s00011-020-01413-2
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10.1126/science.abc4730
10.3390/vaccines9111345
10.1016/j.ymthe.2022.02.016
| null |
[] |
2024-06-28
|
Vaccination is one of the most effective prophylactic public health interventions for the prevention of infectious diseases such as coronavirus disease (COVID-19). Considering the ongoing need for new COVID-19 vaccines, it is crucial to modify our approach and incorporate more conserved regions of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to effectively address emerging viral variants. The nucleocapsid protein is a structural protein of SARS-CoV-2 that is involved in replication and immune responses. Furthermore, this protein offers significant advantages owing to the minimal accumulation of mutations over time and the inclusion of key T-cell epitopes critical for SARS-CoV-2 immunity. A novel strategy that may be suitable for the new generation of vaccines against COVID-19 is to use a combination of antigens, including the spike and nucleocapsid proteins, to elicit robust humoral and potent cellular immune responses, along with long-lasting immunity. The strategic use of multiple antigens aims to enhance vaccine efficacy and broaden protection against viruses, including their variants. The immune response against the nucleocapsid protein from other coronavirus is long-lasting, and it can persist up to 11 years post-infection. Thus, the incorporation of nucleocapsids (N) into vaccine design adds an important dimension to vaccination efforts and holds promise for bolstering the ability to combat COVID-19 effectively. In this review, we summarize the preclinical studies that evaluated the use of the nucleocapsid protein as antigen. This study discusses the use of nucleocapsid alone and its combination with spike protein or other proteins of SARS-CoV-2.
|
[
{
"affiliation": "Departamento de Biomedicina Molecular CINVESTAV IPN, Av. IPN # 2508 Col, San Pedro Zacatenco, Mexico City 07360, Mexico.",
"collective": null,
"firstname": "Noe Juvenal",
"initials": "NJ",
"lastname": "Mendoza-Ramírez"
},
{
"affiliation": "Departamento de Biomedicina Molecular CINVESTAV IPN, Av. IPN # 2508 Col, San Pedro Zacatenco, Mexico City 07360, Mexico.",
"collective": null,
"firstname": "Julio",
"initials": "J",
"lastname": "García-Cordero"
},
{
"affiliation": "Laboratory of Malaria and Vector Research National Institute of Allergy and Infectious Diseases National Institutes of Health, Rockville, MD, USA.",
"collective": null,
"firstname": "Gaurav",
"initials": "G",
"lastname": "Shrivastava"
},
{
"affiliation": "Departamento de Biomedicina Molecular CINVESTAV IPN, Av. IPN # 2508 Col, San Pedro Zacatenco, Mexico City 07360, Mexico.",
"collective": null,
"firstname": "Leticia",
"initials": "L",
"lastname": "Cedillo-Barrón"
}
] |
Journal of immunology research
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38939745
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|
The Key to Increase Immunogenicity of Next-Generation COVID-19 Vaccines Lies in the Inclusion of the SARS-CoV-2 Nucleocapsid Protein.
| null | null | null | null | null | null |
null |
©2023 by Radiation Research Society. All rights of reproduction in any form reserved.
|
10.1667/RADE-22-00208.1
10.1007/s12015-021-10177-z
| null |
[] |
2023-04-05
|
Survivors of acute radiation exposure suffer from the delayed effects of acute radiation exposure (DEARE), a chronic condition affecting multiple organs, including lung, kidney, heart, gastrointestinal tract, eyes, and brain, and often causing cancer. While effective medical countermeasures (MCM) for the hematopoietic-acute radiation syndrome (H-ARS) have been identified and approved by the FDA, development of MCM for DEARE has not yet been successful. We previously documented residual bone marrow damage (RBMD) and progressive renal and cardiovascular DEARE in murine survivors of H-ARS, and significant survival efficacy of 16,16-dimethyl prostaglandin E2 (dmPGE2) given as a radioprotectant or radiomitigator for H-ARS. We now describe additional DEARE (physiological and neural function, progressive fur graying, ocular inflammation, and malignancy) developing after sub-threshold doses in our H-ARS model, and detailed analysis of the effects of dmPGE2 administered before (PGE-pre) or after (PGE-post) lethal total-body irradiation (TBI) on these DEARE. Administration of PGE-pre normalized the twofold reduction of white blood cells (WBC) and lymphocytes seen in vehicle-treated survivors (Veh), and increased the number of bone marrow (BM) cells, splenocytes, thymocytes, and phenotypically defined hematopoietic progenitor cells (HPC) and hematopoietic stem cells (HSC) to levels equivalent to those in non-irradiated age-matched controls. PGE-pre significantly protected HPC colony formation ex vivo by >twofold, long term-HSC in vivo engraftment potential up to ninefold, and significantly blunted TBI-induced myeloid skewing. Secondary transplantation documented continued production of LT-HSC with normal lineage differentiation. PGE-pre reduced development of DEARE cardiovascular pathologies and renal damage; prevented coronary artery rarefication, blunted progressive loss of coronary artery endothelia, reduced inflammation and coronary early senescence, and blunted radiation-induced increase in blood urea nitrogen (BUN). Ocular monocytes were significantly lower in PGE-pre mice, as was TBI-induced fur graying. Increased body weight and decreased frailty in male mice, and reduced incidence of thymic lymphoma were documented in PGE-pre mice. In assays measuring behavioral and cognitive functions, PGE-pre reduced anxiety in females, significantly blunted shock flinch response, and increased exploratory behavior in males. No effect of TBI was observed on memory in any group. PGE-post, despite significantly increasing 30-day survival in H-ARS and WBC and hematopoietic recovery, was not effective in reducing TBI-induced RBMD or any other DEARE. In summary, dmPGE2 administered as an H-ARS MCM before lethal TBI significantly increased 30-day survival and ameliorated RBMD and multi-organ and cognitive/behavioral DEARE to at least 12 months after TBI, whereas given after TBI, dmPGE2 enhances survival from H-ARS but has little impact on RBMD or other DEARE.
|
[
{
"affiliation": "Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202.",
"collective": null,
"firstname": "Tong",
"initials": "T",
"lastname": "Wu"
},
{
"affiliation": "Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202.\nDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana 46202.",
"collective": null,
"firstname": "Louis M",
"initials": "LM",
"lastname": "Pelus"
},
{
"affiliation": "Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202.",
"collective": null,
"firstname": "P Artur",
"initials": "PA",
"lastname": "Plett"
},
{
"affiliation": "Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202.",
"collective": null,
"firstname": "Carol H",
"initials": "CH",
"lastname": "Sampson"
},
{
"affiliation": "Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202.",
"collective": null,
"firstname": "Hui Lin",
"initials": "HL",
"lastname": "Chua"
},
{
"affiliation": "Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202.",
"collective": null,
"firstname": "Alexa",
"initials": "A",
"lastname": "Fisher"
},
{
"affiliation": "Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202.",
"collective": null,
"firstname": "Hailin",
"initials": "H",
"lastname": "Feng"
},
{
"affiliation": "Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana 46202.",
"collective": null,
"firstname": "Liqiong",
"initials": "L",
"lastname": "Liu"
},
{
"affiliation": "Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana 46202.",
"collective": null,
"firstname": "Hongge",
"initials": "H",
"lastname": "Li"
},
{
"affiliation": "Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202.",
"collective": null,
"firstname": "Miguel",
"initials": "M",
"lastname": "Ortiz"
},
{
"affiliation": "Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202.",
"collective": null,
"firstname": "Supriya",
"initials": "S",
"lastname": "Chittajallu"
},
{
"affiliation": "Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana 46202.",
"collective": null,
"firstname": "Qianyi",
"initials": "Q",
"lastname": "Luo"
},
{
"affiliation": "Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana 46202.",
"collective": null,
"firstname": "Ashay D",
"initials": "AD",
"lastname": "Bhatwadekar"
},
{
"affiliation": "Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 46202.",
"collective": null,
"firstname": "Timothy B",
"initials": "TB",
"lastname": "Meyer"
},
{
"affiliation": "Department of Pharmacodynamics, University of Florida, Gainesville, Florida 32611.",
"collective": null,
"firstname": "Xin",
"initials": "X",
"lastname": "Zhang"
},
{
"affiliation": "Department of Pharmacodynamics, University of Florida, Gainesville, Florida 32611.",
"collective": null,
"firstname": "Daohong",
"initials": "D",
"lastname": "Zhou"
},
{
"affiliation": "Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 46202.",
"collective": null,
"firstname": "Kathryn D",
"initials": "KD",
"lastname": "Fischer"
},
{
"affiliation": "Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 46202.",
"collective": null,
"firstname": "David L",
"initials": "DL",
"lastname": "McKinzie"
},
{
"affiliation": "Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202.",
"collective": null,
"firstname": "Steven J",
"initials": "SJ",
"lastname": "Miller"
},
{
"affiliation": "Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202.",
"collective": null,
"firstname": "Christie M",
"initials": "CM",
"lastname": "Orschell"
}
] |
Radiation research
| null |
37014943
|
Further Characterization of Multi-Organ DEARE and Protection by 16,16 Dimethyl Prostaglandin E2 in a Mouse Model of the Hematopoietic Acute Radiation Syndrome.
| null | null | null | null | null | null |
null | null | null | null |
[] |
1968-07-15
| null |
[
{
"affiliation": null,
"collective": null,
"firstname": "P J",
"initials": "PJ",
"lastname": "Grosser"
}
] |
Zeitschrift fur arztliche Fortbildung
| null |
5728375
|
[Contribution to the epidemiology of quarrantine diseases].
| null | null | null | null | null | null |
null |
© 2025 The Author(s). Journal of Forensic Sciences published by Wiley Periodicals LLC on behalf of American Academy of Forensic Sciences.
|
10.1111/1556-4029.15702
10.1146/annurev.en.37.010192.001345
10.1520/JFS14778J
10.1007/s00414-016-1487-0
10.1093/aesa/51.3.261
10.1046/j.1365-2915.2001.00291.x
10.1093/jme/tjaa162
10.1146/annurev-ento-051710-103143
10.1093/jme/tjx119
10.1016/s0379-0738(01)00431-5
10.1093/jmedent/33.6.901
10.1016/j.forsciint.2014.09.023
10.1603/me12114
10.1111/j.1556-4029.2010.01539.x
10.1093/aesa/saw083
10.1093/ee/13.4.1083
10.3382/ps.0622371
10.1603/ME13161
10.4269/ajtmh.1999.61.500
10.3382/ps.2007-00301
10.1186/1471-2180-11-23
10.1007/s00436-007-0522-y
10.1016/j.forsciint.2018.02.004
10.4323/rjlm.2017.283
10.1093/jee/85.6.2291
10.1093/jee/48.6.654
10.1603/me09206
10.1016/j.jinsphys.2016.09.009
10.1016/s0379-0738(01)00413-3
10.1007/s00414-018-1922-5
10.1007/s00414-014-1014-0
10.1093/jme/tjx104
10.1603/EN12123
10.1603/0022-2585(2006)43[1023:codpia]2.0.co;2
10.1603/0022-2585-41.4.785
10.1890/ES14-00022.1
10.2307/1934999
10.1590/S0031-10492005002500001
10.1007/s00436-014-4002-x
10.1007/s00414-014-1029-6
10.1093/jmedent/34.3.353
10.1093/jme/tjaa058
10.1093/jme/tjaa046
10.1590/1809-4392201600773
10.1016/j.forsciint.2020.110333
10.3390/insects12040280
10.1007/s13253-017-0280-y
| null |
[
"Musca domestica",
"abuse and neglect",
"death investigation",
"forensic entomology",
"house fly",
"time of colonization (TOC)"
] |
2025-01-23
|
The house fly, Musca domestica, L. (Diptera: Muscidae), is a filth fly that is often associated with criminal and civil investigations surrounding abuse, neglect, and death of humans and other vertebrates. However, development data, which are crucial for determining the age of immatures collected under forensically relevant circumstances, are limited. Given the lack of data and the recognition of population-specific growth patterns, the aim of this study was to generate data for development of a M. domestica population from Texas, USA, on decomposing lean pork at 24.0°C (i.e., approximate room temperature in Texas) and 37.0°C (i.e., approximate human body temperature). As expected, fly development significantly differed between temperatures with development at the higher temperature taking significantly less time (development from egg to adult emergence occurred c. 48.5% faster at 37.0°C than at 24.0°C). The value of this dataset is demonstrated through an applied comparison with previously published data for the house fly. Differences in development times across life stages for the studies are evident, with shorter time of colonization estimations using the data published by Wang et al. (2018), especially in later life stages. These data represent the first development dataset for the house fly on decomposing flesh in North America. Furthermore, the comparison with the previously published dataset demonstrate data from this study are of value for future forensic investigations in Texas or possibly other parts of the United States where this species is encountered, as they can be used to determine time of colonization.
|
[
{
"affiliation": "Department of Entomology, Texas A&M University, College Station, Texas, USA.",
"collective": null,
"firstname": "Casey A",
"initials": "CA",
"lastname": "Flint"
},
{
"affiliation": "Department of Entomology, Texas A&M University, College Station, Texas, USA.",
"collective": null,
"firstname": "Jennifer",
"initials": "J",
"lastname": "Rhinesmith-Carranza"
},
{
"affiliation": "Department of Entomology, Texas A&M University, College Station, Texas, USA.",
"collective": null,
"firstname": "Riley",
"initials": "R",
"lastname": "Bell"
},
{
"affiliation": "Department of Entomology, Texas A&M University, College Station, Texas, USA.",
"collective": null,
"firstname": "Jeffery K",
"initials": "JK",
"lastname": "Tomberlin"
}
] |
Journal of forensic sciences
| null |
39846129
1539937
10914578
27848012
11434551
32860043
20822449
28874020
11457615
8961637
25447170
23540111
20840295
6669503
24605454
10497998
18577626
21269466
17370089
19287365
2191797
29510361
20962738
1464690
20939391
27646733
11457606
30238161
24811885
28541462
23339798
17017243
15311476
25082014
24929639
9151502
32303768
32173734
32480285
33805865
|
Development of the house fly, Musca domestica L. (Diptera: Muscidae), on pork tissue at two temperatures.
| null | null | null | null | null | null |
null |
Copyright © 2025 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control. Published by Elsevier Ltd. All rights reserved.
|
10.1016/j.jiac.2025.102623
| null |
[
"Antimicrobial stewardship",
"Community pharmacist",
"Home visit",
"Japan",
"Leftover antibiotics"
] |
2025-01-13
|
This cross-sectional study investigated the prevalence and factors associated with leftover antibiotics in Japanese households through pharmacist home visits. The research, conducted in collaboration with pharmaceutical associations in Kyoto and Hirakata, included 37 cases analyzed from October 2023 to March 2024. Participants had a median age of 81 years and received a median of two antibiotic prescriptions in the past year. Leftover antibiotics were found in 18.9 % of cases, with 5 out of 7 cases resulting from prophylactic prescriptions. Levofloxacin was the most common leftover antibiotic. Notably, 27.0 % of participants reported a history of reusing leftover antibiotics. Logistic regression analysis revealed that frequent pharmacist visits (≥2/month) were significantly associated with decreased leftover antibiotics (adjusted OR: 0.02, 95 % CI: 0.00-0.48, p = 0.015), whereas a history of antibiotic reuse increased the likelihood of leftovers (adjusted OR: 20.32, 95 % CI: 1.78-231.33, p = 0.015). Other factors, including the number of antibiotic prescriptions and the presence of medication support, did not show statistically significant associations. This study highlights the potential role of community pharmacists in promoting appropriate antibiotic use and managing leftover medications through home healthcare engagement. The findings suggest that regular pharmacist interventions could significantly improve medication management and contribute to antimicrobial stewardship efforts. Future research should replicate these findings in larger, more diverse populations to enhance generalizability and further explore the long-term impact of pharmacist interventions on antibiotic use patterns.
|
[
{
"affiliation": "Laboratory of Clinical Pharmacoepidemiology, Kyoto Pharmaceutical University, 5 Misasiana-cho, Yamashina-ku, Kyoto, 607-8414, Japan; Department of Pharmacy, Federation of National Public Service Personnel Mutual Aid Associations Hirakata Kohsai Hospital, 1-2-1, Fujisakahigashimachi, Hirakata-shi, Osaka, 573-0153, Japan. Electronic address: [email protected].",
"collective": null,
"firstname": "Keisuke",
"initials": "K",
"lastname": "Sawada"
},
{
"affiliation": "Laboratory of Clinical Pharmacoepidemiology, Kyoto Pharmaceutical University, 5 Misasiana-cho, Yamashina-ku, Kyoto, 607-8414, Japan. Electronic address: [email protected].",
"collective": null,
"firstname": "Yuichi",
"initials": "Y",
"lastname": "Muraki"
},
{
"affiliation": "Laboratory of Clinical Pharmacoepidemiology, Kyoto Pharmaceutical University, 5 Misasiana-cho, Yamashina-ku, Kyoto, 607-8414, Japan. Electronic address: [email protected].",
"collective": null,
"firstname": "Ryo",
"initials": "R",
"lastname": "Inose"
},
{
"affiliation": "Department of Pharmacy, Federation of National Public Service Personnel Mutual Aid Associations Hirakata Kohsai Hospital, 1-2-1, Fujisakahigashimachi, Hirakata-shi, Osaka, 573-0153, Japan. Electronic address: [email protected].",
"collective": null,
"firstname": "Shuji",
"initials": "S",
"lastname": "Kono"
},
{
"affiliation": "Department of Surgery, Federation of National Public Service Personnel Mutual Aid Associations Hirakata Kohsai Hospital, 1-2-1, Fujisakahigashimachi, Hirakata-shi, Osaka, 573-0153, Japan. Electronic address: [email protected].",
"collective": null,
"firstname": "Mitsuru",
"initials": "M",
"lastname": "Tanaka"
},
{
"affiliation": "Hirakata Pharmaceutical Association, 2-14-16, Kinya-hon-machi, Hirakata-shi, Osaka, 573-1197, Japan. Electronic address: [email protected].",
"collective": null,
"firstname": "Toshiaki",
"initials": "T",
"lastname": "Ueba"
},
{
"affiliation": "Kyoto Pharmaceutical Association, 563 Bairincho, Higashiyama-ku, Kyoto, 605-0863, Japan. Electronic address: [email protected].",
"collective": null,
"firstname": "Eiji",
"initials": "E",
"lastname": "Kawakami"
}
] |
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
| null |
39800317
|
Home visit survey on outpatient antibiotic use: Assessing leftover medications and factors influencing appropriate use by community Pharmacists.
| null | null | null | null | null | null |
null | null |
10.2214/ajr.153.5.1031
| null |
[] |
1989-11-01
| null |
[
{
"affiliation": "Department of Radiology, Babies Hospital, Columbia Presbyterian Medical Center, New York, NY 10032.",
"collective": null,
"firstname": "S J",
"initials": "SJ",
"lastname": "Abramson"
},
{
"affiliation": null,
"collective": null,
"firstname": "W E",
"initials": "WE",
"lastname": "Berdon"
},
{
"affiliation": null,
"collective": null,
"firstname": "R A",
"initials": "RA",
"lastname": "Kaufman"
},
{
"affiliation": null,
"collective": null,
"firstname": "C",
"initials": "C",
"lastname": "Ruzal-Shapiro"
}
] |
AJR. American journal of roentgenology
| null |
2801421
|
Hepatic parenchymal and subcapsular gas after hepatic laceration caused by blunt abdominal trauma.
| null | null | null | null | null | null |
null | null | null |
Patient had penile phymosis. Left scrotum had a normal testicle inside. Right scrotum was empty and hypoplastic. There was and ovoid formation near the root of the penis, similar to a testicle. Blood tests were normal. Orchydopexy was carried out following the technique by Bevan. Testicular biopsy was normal.
|
[] |
2004-09-24
|
To report the finding of a rare testicular anomaly.
We performed physical examination, blood tests, surgical exploration, and testicular biopsy.
Patient had penile phymosis. Left scrotum had a normal testicle inside. Right scrotum was empty and hypoplastic. There was and ovoid formation near the root of the penis, similar to a testicle. Blood tests were normal. Orchydopexy was carried out following the technique by Bevan. Testicular biopsy was normal.
Ectopic testicles usually keep the power of fertilization so that their treatment should not be as premature as in the case of cryptorchidism.
|
[
{
"affiliation": "Clínico Quirúrgico Docente, Cmdte. Manuel Fajardo.",
"collective": null,
"firstname": "Francisco",
"initials": "F",
"lastname": "Alonso Domínguez"
},
{
"affiliation": null,
"collective": null,
"firstname": "Vicente",
"initials": "V",
"lastname": "Osorio Acosta"
}
] |
Archivos espanoles de urologia
| null |
15382574
|
[A rare case of testicular ectopia].
| null | null | null | null | null | null |
null | null | null |
(1) Before combining lung recruitment maneuver, 24 h after combining lung recruitment maneuver, and at the end of combining lung recruitment maneuver, the levels of PaO2 and OI of patients were respectively (77 ± 8), (113 ± 5), (142 ± 6) mmHg, and (128 ± 12), (188 ± 8), (237 ± 10) mmHg. As a whole, levels of PaO2 and OI changed significantly at different time points (with F values respectively 860. 96 and 842. 09, P values below 0. 01); levels of pH and PaCO2 showed no obvious changes (with F values respectively 0.35 and 3.13, P values above 0.05). (2) Levels of heart rate, MAP, CVP of all patients and CO of 4 patients who received PiCCO monitoring showed no significant changes at different time points (with F values from 0. 13 to 4. 26, P values above 0.05). Before combining lung recruitment maneuver, 24 h after combining lung recruitment maneuver, and at the end of combining lung recruitment maneuver, the EVLWI values of 4 patients who received PiCCO monitoring were respectively (13.5 ± 1.3), (10.2 ± 1.0), (7.0 ± 0.8) mL/kg ( F =117.00, P <0.01). (3) The patients received mechanical ventilation at 2 to 72 h after burn, lasting for 14-32 (21 ± 13) d. At post injury day 3-14 (7 ± 5) d, lung recruitment maneuver was applied for 2-5 (3.0 ± 2.0) d. All 15 patients recovered without other complications.
|
[] |
2014-11-29
|
To investigate the effects of lung protective ventilation strategy combined with lung recruitment maneuver on ARDS complicating patients with severe burn.
Clinical data of 15 severely burned patients with ARDS admitted to our burn ICU from September 2011 to September 2013 and conforming to the study criteria were analyzed. Right after the diagnosis of acute lung injury/ARDS, patients received mechanical ventilation with lung protective ventilation strategy. When the oxygenation index (OI) was below or equal to 200 mmHg (1 mmHg = 0. 133 kPa), lung recruitment maneuver was performed combining incremental positive end-expiratory pressure. When OI was above 200 mmHg, lung recruitment maneuver was stopped and ventilation with lung protective ventilation strategy was continued. When OI was above 300 mmHg, mechanical ventilation was stopped. Before combining lung recruitment maneuver, 24 h after combining lung recruitment maneuver, and at the end of combining lung recruitment maneuver, variables of blood gas analysis (pH, PaO2, and PaCO2) were obtained by blood gas analyzer, and the OI values were calculated; hemodynamic parameters including heart rate, mean arterial pressure (MAP), central venous pressure (CVP) of all patients and the cardiac output (CO), extravascular lung water index (EVLWI) of 4 patients who received pulse contour cardiac output (PiCCO) monitoring were monitored. Treatment measures and outcome of patients were recorded. Data were processed with analysis of variance of repeated measurement of a single group and LSD test.
(1) Before combining lung recruitment maneuver, 24 h after combining lung recruitment maneuver, and at the end of combining lung recruitment maneuver, the levels of PaO2 and OI of patients were respectively (77 ± 8), (113 ± 5), (142 ± 6) mmHg, and (128 ± 12), (188 ± 8), (237 ± 10) mmHg. As a whole, levels of PaO2 and OI changed significantly at different time points (with F values respectively 860. 96 and 842. 09, P values below 0. 01); levels of pH and PaCO2 showed no obvious changes (with F values respectively 0.35 and 3.13, P values above 0.05). (2) Levels of heart rate, MAP, CVP of all patients and CO of 4 patients who received PiCCO monitoring showed no significant changes at different time points (with F values from 0. 13 to 4. 26, P values above 0.05). Before combining lung recruitment maneuver, 24 h after combining lung recruitment maneuver, and at the end of combining lung recruitment maneuver, the EVLWI values of 4 patients who received PiCCO monitoring were respectively (13.5 ± 1.3), (10.2 ± 1.0), (7.0 ± 0.8) mL/kg ( F =117.00, P <0.01). (3) The patients received mechanical ventilation at 2 to 72 h after burn, lasting for 14-32 (21 ± 13) d. At post injury day 3-14 (7 ± 5) d, lung recruitment maneuver was applied for 2-5 (3.0 ± 2.0) d. All 15 patients recovered without other complications.
Lung protective ventilation strategy combining lung recruitment maneuver can significantly improve the oxygenation in patients with severe burn complicated with ARDS and may therefore improve the prognosis.
|
[
{
"affiliation": null,
"collective": null,
"firstname": "Xiaojian",
"initials": "X",
"lastname": "Li"
},
{
"affiliation": null,
"collective": null,
"firstname": "Xiaomin",
"initials": "X",
"lastname": "Zhong"
},
{
"affiliation": null,
"collective": null,
"firstname": "Zhongyuan",
"initials": "Z",
"lastname": "Deng"
},
{
"affiliation": null,
"collective": null,
"firstname": null,
"initials": null,
"lastname": "Zhang Xuhui"
},
{
"affiliation": null,
"collective": null,
"firstname": "Zhi",
"initials": "Z",
"lastname": "Zhang"
},
{
"affiliation": null,
"collective": null,
"firstname": "Tao",
"initials": "T",
"lastname": "Zhang"
},
{
"affiliation": null,
"collective": null,
"firstname": "Wenbin",
"initials": "W",
"lastname": "Tang"
},
{
"affiliation": null,
"collective": null,
"firstname": "Bib",
"initials": "B",
"lastname": "Chen"
},
{
"affiliation": null,
"collective": null,
"firstname": "Changling",
"initials": "C",
"lastname": "Liu"
},
{
"affiliation": null,
"collective": null,
"firstname": "Wenjuan",
"initials": "W",
"lastname": "Cao"
}
] |
Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns
| null |
25429808
|
[Effects of lung protective ventilation strategy combined with lung recruitment maneuver on patients with severe burn complicated with acute respiratory distress syndrome].
| null | null | null | null | null | null |
null | null |
10.1371/journal.pone.0258626
10.2298/AOO0502069S
10.1038/s41586-020-1969-6
10.1126/science.270.5235.467
10.1371/journal.pone.0188900
10.1038/nature12213
10.1038/ng.3658
10.1093/nar/gkz096
10.1186/s13059-016-0989-x
10.1002/jez.a.307
10.1093/nar/gkj109
10.1186/s12859-019-2634-7
10.1093/bioinformatics/btn182
10.1145/219717.219748
10.1007/978-3-540-76298-0_52
10.1145/2629489
10.1109/ACCESS.2019.2957812
10.1109/JBHI.2015.2392786
10.1109/TCBB.2015.2481399
10.1093/database/bat018
10.1093/bioinformatics/14.8.656
10.1093/nar/gkm1000
10.1093/nar/gki033
10.1186/1750-1172-5-S1-P1
10.1162/tacl_a_00051
10.1101/gr.1239303
10.1016/j.physa.2016.02.049
10.1063/1.5120818
| null |
[] |
2021-10-16
|
Understanding the role of genes in human disease is of high importance. However, identifying genes associated with human diseases requires laborious experiments that involve considerable effort and time. Therefore, a computational approach to predict candidate genes related to complex diseases including cancer has been extensively studied. In this study, we propose a convolutional neural network-based knowledge graph-embedding model (KGED), which is based on a biological knowledge graph with entity descriptions to infer relationships between biological entities. As an application demonstration, we generated gene-interaction networks for each cancer type using gene-gene relationships inferred by KGED. We then analyzed the constructed gene networks using network centrality measures, including betweenness, closeness, degree, and eigenvector centrality metrics, to rank the central genes of the network and identify highly correlated cancer genes. Furthermore, we evaluated our proposed approach for prostate, breast, and lung cancers by comparing the performance with that of existing approaches. The KGED model showed improved performance in predicting cancer-related genes using the inferred gene-gene interactions. Thus, we conclude that gene-gene interactions inferred by KGED can be helpful for future research, such as that aimed at future research on pathogenic mechanisms of human diseases, and contribute to the field of disease treatment discovery.
|
[
{
"affiliation": "School of Electrical Engineering and Computer Science, Gwangju Institute of Science and Technology, Buk-gu, Gwangju, Republic of Korea.",
"collective": null,
"firstname": "Wonjun",
"initials": "W",
"lastname": "Choi"
},
{
"affiliation": "School of Electrical Engineering and Computer Science, Gwangju Institute of Science and Technology, Buk-gu, Gwangju, Republic of Korea.",
"collective": null,
"firstname": "Hyunju",
"initials": "H",
"lastname": "Lee"
}
] |
PloS one
| null |
34653225
30207593
32025007
7569999
29244808
23770567
27618449
30773592
27333808
16902965
16381927
30736752
18586725
25616086
26415184
23584832
9789091
18045790
15360776
15608251
14597658
32237773
|
Identifying disease-gene associations using a convolutional neural network-based model by embedding a biological knowledge graph with entity descriptions.
| null | null | null | null | null | null |
null |
© 2024. The Author(s).
© 2024. The Author(s).
|
10.1186/s13293-024-00629-9
10.1126/science.1111726
10.1016/j.placenta.2005.12.006
10.1016/j.fertnstert.2017.03.012
10.1016/S1550-8579(07)80004-0
10.1371/journal.pone.0158807
10.1186/s13293-020-00299-3
10.1093/aje/kwm024
10.1111/j.1469-7580.2008.01039.x
10.1186/s13293-018-0165-y
10.1186/s13293-022-00470-y
10.1007/s43032-020-00355-8
10.1007/s13237-021-00367-y
10.1186/s13293-021-00381-4
10.1038/s41598-022-13544-z
10.1016/j.fertnstert.2022.11.010
10.1016/j.fertnstert.2018.11.005
10.1371/journal.pgen.0030236
10.1371/journal.pgen.0020190
10.1186/s13059-014-0550-8
10.1093/nar/gkv007
10.1111/j.2517-6161.1995.tb02031.x
10.1093/bioinformatics/btv560
10.1186/s12864-019-5761-7
10.21105/joss.00731
10.1186/1756-8935-8-6
10.1093/nar/gkab637
10.1210/clinem/dgaa503
10.1002/pd.4936
10.1186/gb-2010-11-10-r106
10.1080/15592294.2023.2179726
10.1186/s12915-023-01662-7
10.1186/s13148-022-01279-7
10.1016/j.placenta.2024.03.005
10.1186/s13148-016-0238-x
10.1093/hmg/ddz287
10.1371/journal.pone.0114768
10.32607/20758251-2014-6-2-71-83
10.1152/ajpheart.00958.2015
10.1038/srep14107
10.1016/j.preghy.2018.02.009
10.1111/1471-0528.14163
10.1186/s12884-020-03039-y
10.1080/14767058.2020.1818221
10.1016/j.wneu.2021.03.064
10.1002/cpbi.5
10.1073/pnas.2111256119
10.1016/j.gene.2023.147423
10.1080/15592294.2018.1429857
10.1007/s10495-012-0727-0
10.3389/fgene.2022.1014191
10.1002/dvdy.22755
10.1007/s43032-020-00364-7
10.1055/s-0037-1603570
10.1530/REP-09-0092
10.1016/j.placenta.2021.04.012
10.1080/15592294.2017.1342912
10.1371/journal.pone.0128918
10.1186/s13148-023-01432-w
10.1093/biolre/ioae007
|
Methylation analysis identified 151 differentially methylated probes (DMPs) significant at false discovery rate < 0.05, including 89 (59%) hypermethylated in females. Probe cg17612569 (GABPA, ATP5J) was the most significant CpG site, hypermethylated in males. There were 11 differentially methylated regions affected by fetal sex, with transcription factors ZNF300 and ZNF311 most significantly hypermethylated in males and females, respectively. RNA-sequencing identified 152 genes significantly sexually dimorphic at false discovery rate < 0.05. The 151 DMPs were associated with 18 genes with gene downregulation (P < 0.05) in the direction of hypermethylation, including 2 genes significant at false discovery rate < 0.05 (ZNF300 and CUB and Sushi multiple domains 1, CSMD1). Both genes, as well as Family With Sequence Similarity 228 Member A (FAM228A), showed significant correlation between DNA methylation and sexually dimorphic gene expression, though FAM228A DNA methylation was less sexually dimorphic. Comparison with other sex differences studies found that cg17612569 is male-hypermethylated across gestation in placenta and in human blood up to adulthood.
|
[
"DNA methylation",
"Early pregnancy",
"Fetal sex",
"Healthy pregnancy",
"Placenta",
"Sexual dimorphism",
"Total RNA-seq"
] |
2024-08-17
|
Fetal sex and placental development impact pregnancy outcomes and fetal-maternal health, but the critical timepoint of placenta establishment in first trimester is understudied in human pregnancies.
Pregnant subjects were recruited in late first trimester (weeks 10-14) at time of chorionic villus sampling, a prenatal diagnostic test. Leftover placenta tissue was collected and stored until birth outcomes were known, then DNA and RNA were isolated from singleton, normal karyotype pregnancies resulting in live births. DNA methylation was measured with the Illumina Infinium MethylationEPIC BeadChip array (n = 56). Differential methylation analysis compared 25 females versus 31 males using a generalized linear model on 743,461 autosomal probes. Gene expression sex differences were analyzed with RNA-sequencing (n = 74). An integrated analysis was performed using linear regression to correlate gene expression and DNA methylation in 51 overlapping placentas.
Methylation analysis identified 151 differentially methylated probes (DMPs) significant at false discovery rate < 0.05, including 89 (59%) hypermethylated in females. Probe cg17612569 (GABPA, ATP5J) was the most significant CpG site, hypermethylated in males. There were 11 differentially methylated regions affected by fetal sex, with transcription factors ZNF300 and ZNF311 most significantly hypermethylated in males and females, respectively. RNA-sequencing identified 152 genes significantly sexually dimorphic at false discovery rate < 0.05. The 151 DMPs were associated with 18 genes with gene downregulation (P < 0.05) in the direction of hypermethylation, including 2 genes significant at false discovery rate < 0.05 (ZNF300 and CUB and Sushi multiple domains 1, CSMD1). Both genes, as well as Family With Sequence Similarity 228 Member A (FAM228A), showed significant correlation between DNA methylation and sexually dimorphic gene expression, though FAM228A DNA methylation was less sexually dimorphic. Comparison with other sex differences studies found that cg17612569 is male-hypermethylated across gestation in placenta and in human blood up to adulthood.
Overall, sex dimorphic differential methylation with associated differential gene expression in the first trimester placenta is small, but there remain significant genes that may be regulated through methylation leading to differences in the first trimester placenta.
Fetal sex and placenta development affect pregnancy outcomes for both the fetus and mother throughout pregnancy, including risk of miscarriages, preterm birth, preeclampsia, and other outcomes. Epigenetics, the “overlay” of regulatory signals on DNA which affects how DNA is read, is not well understood in early pregnancy when critical placenta developments are happening that affect the rest of pregnancy. Here, we use leftover placenta biopsy samples (n = 56) donated by Cedars-Sinai patients with informed consent to learn about first trimester human placenta DNA methylation differences due to fetal sex. Out of the total 743,461 sites analyzed, we identified 151 sites significantly affected by fetal sex after correcting p-values to reduce false positives (false discovery rate < 0.05). We also performed an analysis to look at multiple sites and identified 11 regions across the genome with significant DNA methylation changes due to fetal sex. Furthermore, because DNA methylation is a regulatory mark on DNA which typically dampens gene expression, we also compared the DNA methylation sex differences to placental RNA-sequencing gene expression analysis using the same tissue from a mostly overlapping patient group (n = 74 total sequenced, n = 51 overlap). We identify 18 genes which show both significant DNA methylation differences and gene expression changes. The most significant gene was transcription factor ZNF300 with higher DNA methylation in males and reduced gene expression in males (and thus higher gene expression in females). This study identifies some sex differences that continue until later pregnancy and others that are unique to first trimester.
|
[
{
"affiliation": "Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, 8635 West 3rd Street, Suite 160, Los Angeles, CA, 90048, USA.",
"collective": null,
"firstname": "Tania L",
"initials": "TL",
"lastname": "Gonzalez"
},
{
"affiliation": "Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, 8635 West 3rd Street, Suite 160, Los Angeles, CA, 90048, USA.",
"collective": null,
"firstname": "Bryn E",
"initials": "BE",
"lastname": "Willson"
},
{
"affiliation": "Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, 8635 West 3rd Street, Suite 160, Los Angeles, CA, 90048, USA.\nDavid Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.",
"collective": null,
"firstname": "Erica T",
"initials": "ET",
"lastname": "Wang"
},
{
"affiliation": "The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.",
"collective": null,
"firstname": "Kent D",
"initials": "KD",
"lastname": "Taylor"
},
{
"affiliation": "Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, 8635 West 3rd Street, Suite 160, Los Angeles, CA, 90048, USA.",
"collective": null,
"firstname": "Allynson",
"initials": "A",
"lastname": "Novoa"
},
{
"affiliation": "Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, 8635 West 3rd Street, Suite 160, Los Angeles, CA, 90048, USA.",
"collective": null,
"firstname": "Akhila",
"initials": "A",
"lastname": "Swarna"
},
{
"affiliation": "Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, 8635 West 3rd Street, Suite 160, Los Angeles, CA, 90048, USA.",
"collective": null,
"firstname": "Juanita C",
"initials": "JC",
"lastname": "Ortiz"
},
{
"affiliation": "Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, 8635 West 3rd Street, Suite 160, Los Angeles, CA, 90048, USA.",
"collective": null,
"firstname": "Gianna J",
"initials": "GJ",
"lastname": "Zeno"
},
{
"affiliation": "Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.\nDivision of Rheumatology, Department of Medicine, Kao Autoimmune Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.",
"collective": null,
"firstname": "Caroline A",
"initials": "CA",
"lastname": "Jefferies"
},
{
"affiliation": "Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, 8635 West 3rd Street, Suite 160, Los Angeles, CA, 90048, USA.\nSamuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.",
"collective": null,
"firstname": "Kate",
"initials": "K",
"lastname": "Lawrenson"
},
{
"affiliation": "The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.",
"collective": null,
"firstname": "Jerome I",
"initials": "JI",
"lastname": "Rotter"
},
{
"affiliation": "The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.",
"collective": null,
"firstname": "Yii-Der Ida",
"initials": "YI",
"lastname": "Chen"
},
{
"affiliation": "Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, 8635 West 3rd Street, Suite 160, Los Angeles, CA, 90048, USA.\nDavid Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.",
"collective": null,
"firstname": "John",
"initials": "J",
"lastname": "Williams"
},
{
"affiliation": "Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.",
"collective": null,
"firstname": "Jinrui",
"initials": "J",
"lastname": "Cui"
},
{
"affiliation": "Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.",
"collective": null,
"firstname": "Mark O",
"initials": "MO",
"lastname": "Goodarzi"
},
{
"affiliation": "Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, 8635 West 3rd Street, Suite 160, Los Angeles, CA, 90048, USA. [email protected].\nDavid Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. [email protected].\nDepartment of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA. [email protected].",
"collective": null,
"firstname": "Margareta D",
"initials": "MD",
"lastname": "Pisarska"
}
] |
Biology of sex differences
| null |
39152463
|
Sexually dimorphic DNA methylation and gene expression patterns in human first trimester placenta.
| null | null | null | null | null | null |
null | null | null | null |
[] |
2021-10-13
|
Abdominal actinomycosis refers to a rare chronic suppurative infectious occurrence, caused by filamentous Gram-positive microaerophilic and anaerobic bacteria Actinomyces, that may appear as an abdominal mass and/or abscess, feasibly mimicking a malignancy 1,2. Due to its rarity and unspecific clinical evidence, the majority of cases are diagnosed after tissue specimen. We hereby report a case of a 69-year-old patient with a one week worsening abdominal pain and swelling. A large tender palpable mass in the epigastric region was noted on physical exam. An ultrasound-guided drainage followed by a surgical excision approach became both a way to confirm the diagnosis and a therapeutic tool. Diagnosis of actinomycosis was made on histopathology and microbiology. Even though the incidence of actinomycosis has decreased, the abdominal presentation has been observed with increasing frequency 3. KEY WORDS: Actinomycosis, Abdominal wall, Abdominal abscess, foreign-body reaction, Colonic neoplasms.
L’Actinomicosi rappresenta un processo infiammatorio e granulomatoso cronico prodotto da un patogeno opportunista responsabile nel 20% dei casi di un severo processo infettivo addominale. L’incidenza globale di casi registrati di actinomicosi risulta in diminuzione, mentre l’interessamento pelvico ed addominale della patologia è in aumento. Stadi avanzati del quadro cronico suppurativo che contraddistingue l’actinomicosi addominopelvica possono manifestarsi quali massa addominale con multiple cavità ascessuali ed un severo quadro infettivo che può arrivare a coinvolgere la parete addominale con formazione di fistole o compromettere il perineo ed altri organi limitrofi. Date la rarità e l’aspecificità nelle evidenze clinico-radiologiche di questa patologia, la gran parte dei casi viene identificata grazie all’analisi istopatologica e microbiologica colturale. Nella nostra esperienza riportiamo il caso di un paziente di 69 anni affetto da dolore addominale ingravescente, associato all’obiettività clinica di massa palpabile epigastrica ed a quella radiologica di neoformazione contenente un presunto corpo estraneo e coinvolgente il colon trasverso. Il quadro clinico lasciava spazio ad un ampio spettro di diagnosi differenziali compreso il sospetto di malignità. L’aspirazione eco-guidata della massa ha rivelato l’eccezionale presenza in sede addominale di colonie di Actinomyces odontolyticus, noto commensale del cavo orale. Il paziente è stato sottoposto ad asportazione en bloc della massa che, come confermato anche mediante endoscopia intraoperatoria, non presentava franchi aspetti invasivi verso gli organi limitrofi; la diagnosi è stata ottenuta mediante analisi istologica e batteriologica. Pensiamo che il paziente, solito all’utilizzo quotidiano di filo interdentale, possa averne incidentalmente ingerito una minima parte che è servita quale veicolo per la migrazione del batterio commensale orale sino alla sede colica. L’inclusione sperimentale di frammenti plastici di filo interdentale ha rivelato importanti somiglianze con il materiale estraneo riscontrato nel campione istologico del paziente. Il trattamento chirurgico insieme con la somministrazione di alti dosaggi antibiotici hanno consentito la risoluzione del quadro clinico. Spesso i reperti clinico-radiologici di questa patologia fanno supporre una eziologia maligna, per cui l’analisi istologica e microbiologica colturale divengono mandatorie per raggiungere una corretta diagnosi differenziale e definire il trattamento più adeguato, soprattutto alla luce delle severe complicanze che altrimenti potrebbero derivarne. Una miglior consapevolezza della patologia deve incoraggiare il tasso di sospetto e possibilmente guidare verso una diagnosi pre-operatoria nell’ottica di definire la strategia di trattamento più opportuna.
|
[
{
"affiliation": null,
"collective": null,
"firstname": "Manuel",
"initials": "M",
"lastname": "Valeri"
},
{
"affiliation": null,
"collective": null,
"firstname": "Lavinia",
"initials": "L",
"lastname": "Amato"
},
{
"affiliation": null,
"collective": null,
"firstname": "Michela",
"initials": "M",
"lastname": "Boncompagni"
},
{
"affiliation": null,
"collective": null,
"firstname": "Roberto",
"initials": "R",
"lastname": "Ciaccarini"
},
{
"affiliation": null,
"collective": null,
"firstname": "Rachele",
"initials": "R",
"lastname": "Del Sordo"
},
{
"affiliation": null,
"collective": null,
"firstname": "Adolfo",
"initials": "A",
"lastname": "Petrina"
}
] |
Annali italiani di chirurgia
| null |
34636341
|
A rare finding of Actinomyces odontolyticus abdominal actinomycosis presenting as abdominal wall and pericolic pseudotumoral mass.
| null | null | null | null | null | null |
null | null |
10.1007/s00106-020-00876-3
10.1097/MAO.0000000000001734
10.1097/MAO.0000000000001038
10.1007/s00106-018-0531-4
10.3390/jcm8101614
10.1007/s00106-012-2652-5
10.1007/s11548-013-0973-9
10.1017/S0022215115002042
10.3109/00016480903559749
10.1016/j.ijporl.2018.05.033
10.1097/MAO.0b013e318291c651
10.1016/j.ijscr.2016.11.057
10.1007/s00330-015-3983-x
10.1371/journal.pone.0221484
10.1007/s00405-014-3452-1
10.1097/MAO.0000000000000347
10.1097/MAO.0000000000000405
10.1097/MAO.0000000000001834
10.1007/s00106-015-0087-5
10.1097/MAO.0000000000000881
10.2147/MDER.S39691
10.1097/MAO.0000000000000682
10.1097/MAO.0000000000001394
10.1186/s40463-018-0316-5
10.1097/MAO.0000000000001358
10.1111/coa.12484
10.3109/00016489.2014.900703
10.1080/00016489.2017.1420915
10.1179/1467010014Z.000000000155
10.1007/s00106-014-2851-3
10.1016/j.conctc.2018.03.007
10.1097/MAO.0000000000002201
10.1007/s00405-014-2976-8
10.1055/s-0035-1564329
| null |
[
"Hearing aids",
"Hearing loss, conductive",
"Hearing loss, mixed, conductive-sensorineural",
"Otologic surgical procedures",
"Patients"
] |
2020-06-07
|
Here, we describe the surgical technique for implanting a new, active, transcutaneous bone conduction hearing aid. The implant technology is based on a system that has been in use reliably since 2012. The geometry of the new implant has been adapted based on experience with previously introduced implants. The surgery was feasible, standardized, and safe. Due to the optimized geometric design that improved the bone fit, it is not necessary to use specialized, detailed preoperative planning, except in challenging anatomical conditions; e.g., in young children, malformations, poor pneumatization, or after a canal wall down mastoidectomy.
Im vorliegenden Beitrag wird die Technik der Implantation eines neuen aktiven, transkutanen, knochenverankerten Hörimplantats beschrieben. Das Hörimplantat basiert technisch auf einem System, das bereits seit 2012 zuverlässig im Einsatz ist. Die Geometrie des neuen Systems ist an die Erfahrungen mit vorangegangenen Implantaten angepasst. Die Op. ist standardisiert und sicher durchführbar. Aufgrund der optimierten Bauform mit verbesserter Passfähigkeit im Schläfenbein erscheint eine spezielle, detaillierte präoperative Planung der Implantation nur noch in Fällen mit besonderen anatomischen Gegebenheiten, wie z. B. bei Kindern, bei Fehlbildungen, bei schlechter Pneumatisation des Schläfenbeins und nach Anlage einer offenen Mastoidhöhle notwendig.
|
[
{
"affiliation": "Universitätsklinik und Poliklinik für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie, Universitätsmedizin Halle, Martin-Luther-Universität Halle-Wittenberg, Ernst-Grube-Str. 40, 06120, Halle (Saale), Deutschland. [email protected].",
"collective": null,
"firstname": "S K",
"initials": "SK",
"lastname": "Plontke"
},
{
"affiliation": "Universitätsklinik und Poliklinik für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie, Universitätsmedizin Halle, Martin-Luther-Universität Halle-Wittenberg, Ernst-Grube-Str. 40, 06120, Halle (Saale), Deutschland.",
"collective": null,
"firstname": "G",
"initials": "G",
"lastname": "Götze"
},
{
"affiliation": "Universitätsklinik und Poliklinik für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie, Universitätsmedizin Halle, Martin-Luther-Universität Halle-Wittenberg, Ernst-Grube-Str. 40, 06120, Halle (Saale), Deutschland.",
"collective": null,
"firstname": "C",
"initials": "C",
"lastname": "Wenzel"
},
{
"affiliation": "Universitätsklinik und Poliklinik für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie, Universitätsmedizin Halle, Martin-Luther-Universität Halle-Wittenberg, Ernst-Grube-Str. 40, 06120, Halle (Saale), Deutschland.",
"collective": null,
"firstname": "T",
"initials": "T",
"lastname": "Rahne"
},
{
"affiliation": "Universitätsklinik und Poliklinik für Hals-Nasen-Ohren-Heilkunde \"Otto Körner\", Universitätsmedizin Rostock, Rostock, Deutschland.",
"collective": null,
"firstname": "R",
"initials": "R",
"lastname": "Mlynski"
}
] |
HNO
| null |
32504115
|
[Implantation of a new active bone conduction hearing device with optimized geometry. German version].
| null | null | null | null | null | null |
By identifying obstacles related to the professional setting, patient behavior, and organization of care, our study identified resources and a framework for establishing collaborative strategies to facilitate follow-up care of childhood cancer survivors in China.
| null |
10.1200/GO.20.00534
10.1148/radiol.2020200905
|
The Delphi survey identified eight high-priority late effects for harmonization within CCCG: osteonecrosis, osteoporosis, left ventricular dysfunction, secondary brain tumors, treatment-related myeloid leukemia, gonadal dysfunction, growth hormone deficiency, and neurocognitive deficits. The common barriers to implementing survivorship programs include lack of support and resources for clinicians to provide follow-up care. Patients were also concerned about privacy issues and lacked awareness of late effects. Many institutions also lacked rehabilitation expertise and referral pathways.
|
[] |
2021-02-17
|
Survivors of childhood cancer often experience treatment-related chronic health conditions. Given its vast population, China shares a large proportion of the global childhood cancer burden. Yet, screening and treatment of late effects in survivors of childhood cancer remain underaddressed in most regions of China. This study aimed to identify high-priority late effects for harmonizing screening guidelines within the Chinese Children's Cancer Group (CCCG), as well as barriers and enablers of the implementation of surveillance recommendations in local practice.
To establish clinical consensus, 12 expert panelists who represent major institutions within the CCCG completed a Delphi survey and participated in a focus group discussion. The survey solicited ratings of the prevalence, severity, and priority for screening of 45 late effects. Major themes identified from the focus group were analyzed using thematic analysis.
The Delphi survey identified eight high-priority late effects for harmonization within CCCG: osteonecrosis, osteoporosis, left ventricular dysfunction, secondary brain tumors, treatment-related myeloid leukemia, gonadal dysfunction, growth hormone deficiency, and neurocognitive deficits. The common barriers to implementing survivorship programs include lack of support and resources for clinicians to provide follow-up care. Patients were also concerned about privacy issues and lacked awareness of late effects. Many institutions also lacked rehabilitation expertise and referral pathways.
By identifying obstacles related to the professional setting, patient behavior, and organization of care, our study identified resources and a framework for establishing collaborative strategies to facilitate follow-up care of childhood cancer survivors in China.
|
[
{
"affiliation": "School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.",
"collective": null,
"firstname": "Yin Ting",
"initials": "YT",
"lastname": "Cheung"
},
{
"affiliation": "Department of Hematology and Oncology, Guangzhou Women and Children's Medical Center, Guangzhou, China.",
"collective": null,
"firstname": "Hui",
"initials": "H",
"lastname": "Zhang"
},
{
"affiliation": "Key Laboratory of Pediatric Hematology and Oncology Ministry of Health, Department of Hematology and Oncology, Pediatric Translational Medicine Institute, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.",
"collective": null,
"firstname": "Jiaoyang",
"initials": "J",
"lastname": "Cai"
},
{
"affiliation": "School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.",
"collective": null,
"firstname": "Lung Wai Phillip",
"initials": "LWP",
"lastname": "Au-Doung"
},
{
"affiliation": "School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.",
"collective": null,
"firstname": "Lok Sum",
"initials": "LS",
"lastname": "Yang"
},
{
"affiliation": "Department of Hematology and Oncology, Guangzhou Women and Children's Medical Center, Guangzhou, China.",
"collective": null,
"firstname": "Cuixia",
"initials": "C",
"lastname": "Yan"
},
{
"affiliation": "Pediatric Department, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.",
"collective": null,
"firstname": "Fen",
"initials": "F",
"lastname": "Zhou"
},
{
"affiliation": "State Key Laboratory of Experimental Hematology, Department of Paediatrics Haematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.",
"collective": null,
"firstname": "Xiaojuan",
"initials": "X",
"lastname": "Chen"
},
{
"affiliation": "Division of Hematology, Children's Hospital, Chongqing Medical University, Chongqing, China.",
"collective": null,
"firstname": "Xianmin",
"initials": "X",
"lastname": "Guan"
},
{
"affiliation": "Department of Oncology, St Jude Children's Research Hospital, Memphis, TN.",
"collective": null,
"firstname": "Ching-Hon",
"initials": "CH",
"lastname": "Pui"
},
{
"affiliation": "Department of Oncology, St Jude Children's Research Hospital, Memphis, TN.\nDepartment of Epidemiology and Cancer Control, St Jude Children's Research Hospital, Memphis, TN.",
"collective": null,
"firstname": "Melissa M",
"initials": "MM",
"lastname": "Hudson"
},
{
"affiliation": "Department of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.\nHong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong, Hong Kong.\nDepartment of Paediatrics and Adolescent Medicine, Hong Kong Children's Hospital, Hong Kong.",
"collective": null,
"firstname": "Chi-Kong",
"initials": "CK",
"lastname": "Li"
}
] |
JCO global oncology
| null |
33591820
24857133
17035650
24331199
15576413
23281199
29377070
17093273
25917566
26605296
31045474
30705079
24161636
25943901
29222704
17872937
31055708
18203425
26605970
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27685253
27684572
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26150441
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32505251
0
32349120
26187488
28905191
29914858
31475766
23758898
28374090
24319070
30924901
31211103
29226000
22586152
|
Identifying Priorities for Harmonizing Guidelines for the Long-Term Surveillance of Childhood Cancer Survivors in the Chinese Children Cancer Group (CCCG).
| null | null | null | null | null | null |
null |
Copyright © 2022 by The Author(s). Published by S. Karger AG, Basel.
|
10.1159/000527094
| null |
[
"En face imaging",
"Hypotony maculopathy",
"Ocular trauma",
"Traumatic cyclodialysis",
"Ultra-widefield optical coherence tomography"
] |
2022-12-06
|
The aim was to investigate the structural changes of the retina using en face ultra-widefield optical coherence tomography (OCT) images during the treatment of hypotony maculopathy with traumatic cyclodialysis. Case 1 was a 43-year-old male patient with visual crowding in his left eye (metallic wire injury that occurred 3 weeks previously) who was referred to our department. Although best-corrected visual acuity was 20/20 in his left eye on initial evaluation, intraocular pressure was 6 mm Hg. Case 2 was a 20-year-old male patient with visual crowding in his left eye (baseball ball injury that occurred 4 weeks previously) who was referred to our department. Although best-corrected visual acuity was 16/20 in his left eye on initial examination, intraocular pressure was 5 mm Hg. Surgical interventions were performed in both cases. En face ultra-widefield OCT images were able to be used to trace dynamic changes before the intervention and up to 1 year later. The images obtained in these two cases made it possible to confirm the progress from wrinkles on the surface of the retina to normalization of vascular structure and improvement of ellipsoid zone disruption. En face ultra-widefield OCT is useful for monitoring multilayer structures of the retina in hypotony maculopathy cases.
|
[
{
"affiliation": "Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Osaka City University, Osaka, Japan.",
"collective": null,
"firstname": "Yuri",
"initials": "Y",
"lastname": "Nagatomi"
},
{
"affiliation": "Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Osaka City University, Osaka, Japan.",
"collective": null,
"firstname": "Mizuki",
"initials": "M",
"lastname": "Tagami"
},
{
"affiliation": "Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Osaka City University, Osaka, Japan.",
"collective": null,
"firstname": "Norihiko",
"initials": "N",
"lastname": "Misawa"
},
{
"affiliation": "Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Osaka City University, Osaka, Japan.",
"collective": null,
"firstname": "Atsushi",
"initials": "A",
"lastname": "Sakai"
},
{
"affiliation": "Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Osaka City University, Osaka, Japan.",
"collective": null,
"firstname": "Yusuke",
"initials": "Y",
"lastname": "Haruna"
},
{
"affiliation": "Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Osaka City University, Osaka, Japan.",
"collective": null,
"firstname": "Shigeru",
"initials": "S",
"lastname": "Honda"
}
] |
Case reports in ophthalmology
| null |
36466068
1945314
20051856
17542978
26457396
27749497
29631900
23196648
|
En Face Images Using Ultra-Widefield Optical Coherence Tomography in 2 Cases of Traumatic Hypotony Maculopathy before and after Surgical Intervention.
| null | null | null | null | null | null |
The median recovery time was longer than other similar studies. Therefore, due attention should be given to the identified predictors of the recovery time.
|
Copyright: © 2025 Bekele et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
|
10.1371/journal.pone.0316839
10.1016/S2214-109X(18)30408-X
10.1016/S0140-6736(10)60224-6
10.1371/journal.pone.0213238
10.2147/PHMT.S321184
10.2471/blt.07.044545
10.7189/jogh.06.010408
10.1371/journal.pone.0207203
10.7196/sajch.663
10.1016/S0140-6736(03)13779-8
10.1155/2020/1606783
10.1177/20503121221078445
10.17140/goroj-8-157
10.4103/jfmpc.jfmpc_2006_21
10.1155/2015/167261
10.1016/j.heliyon.2020.e04732
10.1186/s12889-022-14842-x
10.54724/lc.2023.e8
10.1371/journal.pone.0239655
10.1371/journal.pone.0122052
10.21101/cejph.a4164
10.3390/ijerph192416733
10.1186/s12887-023-04144-5
10.1097/INF.0b013e3181906e40
10.1371/journal.pone.0243636
| null |
[] |
2025-04-15
|
Pneumonia is an inflammation of lung parenchyma. The World Health Organization estimated 156 million cases of pneumonia occur annually. Out of them, 20 million cases severe enough to require hospitalization, and each year 1.2 million deaths occur among under-five children. Despite studies and initiatives aimed at reducing pneumonia related deaths in children, Ethiopia is ranked sixth among top fifteen countries in terms of pneumonia related morbidity and mortality.
This study aimed to assess the time to recovery from severe pneumonia and its predictors among children aged 2-59 months admitted to the pediatric ward of Jimma University Medical Center; Southwest, Ethiopia, 2023.
A facility-based retrospective cohort study was carried out among 426 children aged between 2 and 59 months. Five years of medical records, from 2018-2022, were reviewed. A simple random sampling technique was used. Data entry was done in Epidata version 4.6 and exported to and analyzed by STATA version 15. Variables with p-value < 0.25 at Bivariable Cox regression analysis were selected for the multivariable Cox proportional model. A multivariable Cox regression model with 95% confidence interval and Adjusted Hazard Ratio was used to identify a significant predictor of time to recovery at a p-value < 0.05.
The median recovery time was 4 days (IQR: 3, 7). Incidence rate of recovery was 15.78 per 100-person day (95% CI 14.2-17.5). The presence of co-morbidity (AHR; 0.7, 95% CI (0.54-0.91)), being treated with Ceftazidime and Vancomycin (AHR; 0.29, 95% CI (0.14-0.60)), antibiotic change (AHR; 0.74, 95% CI (0.58-0.95)) and late presentation to the Hospital (AHR; 0.58, 95% CI (0.43-0.78)) were statistically significant predictors that prolong recovery time.
The median recovery time was longer than other similar studies. Therefore, due attention should be given to the identified predictors of the recovery time.
|
[
{
"affiliation": "Jimma University Medical Center, Jimma, Ethiopia.",
"collective": null,
"firstname": "Getu Girma",
"initials": "GG",
"lastname": "Bekele"
},
{
"affiliation": "Jimma University Medical Center, Jimma, Ethiopia.",
"collective": null,
"firstname": "Tola Getachew",
"initials": "TG",
"lastname": "Bekele"
},
{
"affiliation": "Jimma University, Institute of Health, Faculty of Public Health, Department of Epidemiology, Jimma, Ethiopia.",
"collective": null,
"firstname": "Masrie",
"initials": "M",
"lastname": "Getnet"
},
{
"affiliation": "Jimma University, Institute of Health, Faculty of Public Health, Department of Epidemiology, Jimma, Ethiopia.",
"collective": null,
"firstname": "Dawit",
"initials": "D",
"lastname": "Regassa"
}
] |
PloS one
| null |
40233064
|
Time-to-recovery from severe pneumonia and its predictors among children 2-59 months of age admitted to the pediatric ward of Jimma University Medical Center, Southwest Ethiopia, 2023: A retrospective cohort study.
| null | null | null | null | null | null |
null | null |
10.3390/cancers17040711
10.1634/theoncologist.2014-0113
10.1002/hon.2711
10.1093/annonc/mdf662
10.1111/j.1600-0609.2005.00438.x
10.1007/s00277-017-2940-y
10.1007/s11136-010-9670-0
10.1385/MO:18:1:85
10.1007/s11764-007-0004-3
10.3390/cancers15153885
10.1016/S0140-6736(85)92589-9
10.2466/pr0.97.1.195-202
10.1002/cam4.1338
10.1080/00207599008247865
10.1111/tri.12895
10.1002/cncr.22581
10.1007/s11136-006-0025-9
10.1097/00005650-199303000-00006
10.1186/s12939-022-01622-7
10.1016/S0959-8049(98)00136-1
10.1111/j.1365-2354.2004.00546.x
10.1183/09031936.00059814
10.1097/00005768-199911001-00019
10.1007/s00520-023-07691-w
10.1080/01635581.2021.1881570
10.1200/OP.21.00694
10.1182/hematology.2020000100
10.3390/curroncol30110692
10.1186/s12889-021-10433-4
10.1186/1477-7525-1-44
| null |
[
"non-Hodgkin lymphoma",
"population-based data",
"quality of life"
] |
2025-02-26
|
Background/Objectives: Non-Hodgkin lymphoma (NHL) represents 63% of all hematological malignancies in France, with diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) being the two most frequent forms. With the improvement of therapeutics, the issue of health-related quality of life (HRQoL) is becoming increasingly crucial for these patients. The aim was to compare HRQoL of NHL survivors with that of the general French population and to identify factors associated with HRQoL in NHL survivors. Methods: We conducted a population-based study among living patients from three registries of hematological malignancies, using standardized questionnaires, including the SF-12, in September 2023. The data collected were compared to those of a normative general French cohort. Results: In total, 493 patients completed the study questionnaires, yielding a response rate of 36%. The median time since diagnosis was 8 years (IQR 6-10) These NHL survivors reported lower HRQoL compared to the general French population, except in terms of bodily pain (p < 0.01). Each one-year increase in the time since diagnosis was associated with an increase in social functioning (p = 0.009). Men had better general health (p = 0.01) and less bodily pain (p = 0.007) than women. Higher income was associated with better HRQoL (p < 0.01). Underweight or obesity were associated with poorer physical functioning (p = 0.008). The presence of comorbidities, socioeconomic deprivation, anxiety, and depression were associated with poorer HRQoL (p < 0.01). Conclusions: This study provides valuable information of HRQoL values for comparison in further follow-up studies and proposes measures that could be implemented to improve the HRQoL of NHL survivors.
|
[
{
"affiliation": "Registry of Hematological Malignancies of Côte d'Or, Dijon-Bourgogne University Hospital, 21000 Dijon, France.\nINSERM, UMR1231, Bourgogne Franche-Comté University, 21000 Dijon, France.",
"collective": null,
"firstname": "Stephane Kroudia",
"initials": "SK",
"lastname": "Wasse"
},
{
"affiliation": "INSERM, UMR1231, Bourgogne Franche-Comté University, 21000 Dijon, France.\nBreast and Gynecologic Cancer Registry of Côte d'Or, Georges François Leclerc Comprehensive Cancer Centre, 21000 Dijon, France.",
"collective": null,
"firstname": "Emerline",
"initials": "E",
"lastname": "Assogba"
},
{
"affiliation": "Registry of Hematological Malignancies of Gironde, Bergonié Institute, 33076 Bordeaux, France.",
"collective": null,
"firstname": "Sebastien",
"initials": "S",
"lastname": "Orazio"
},
{
"affiliation": "Registry of Hematological Malignancies of Côte d'Or, Dijon-Bourgogne University Hospital, 21000 Dijon, France.\nINSERM, UMR1231, Bourgogne Franche-Comté University, 21000 Dijon, France.",
"collective": null,
"firstname": "Kueshivi Midodji",
"initials": "KM",
"lastname": "Atsou"
},
{
"affiliation": "Clinical Hematology Unit, Dijon Bourgogne University Hospital, 21000 Dijon, France.",
"collective": null,
"firstname": "Cédric",
"initials": "C",
"lastname": "Rossi"
},
{
"affiliation": "Registry of Hematological Malignancies of Côte d'Or, Dijon-Bourgogne University Hospital, 21000 Dijon, France.\nINSERM, UMR1231, Bourgogne Franche-Comté University, 21000 Dijon, France.",
"collective": null,
"firstname": "Adrien",
"initials": "A",
"lastname": "Guilloteau"
},
{
"affiliation": "Registry of Hematological Malignancies of Côte d'Or, Dijon-Bourgogne University Hospital, 21000 Dijon, France.\nINSERM, UMR1231, Bourgogne Franche-Comté University, 21000 Dijon, France.",
"collective": null,
"firstname": "Sophie",
"initials": "S",
"lastname": "Gauthier"
},
{
"affiliation": "Registry of Hematological Malignancies of Côte d'Or, Dijon-Bourgogne University Hospital, 21000 Dijon, France.\nINSERM, UMR1231, Bourgogne Franche-Comté University, 21000 Dijon, France.",
"collective": null,
"firstname": "Stéphanie",
"initials": "S",
"lastname": "Girard"
},
{
"affiliation": "Registry of Hematological Malignancies of Caen, Caen University Hospital, 14000 Caen, France.",
"collective": null,
"firstname": "Jean-Marc",
"initials": "JM",
"lastname": "Poncet"
},
{
"affiliation": "Registry of Hematological Malignancies of Caen, Caen University Hospital, 14000 Caen, France.\nClinical Hematology Unit, Caen University Hospital, 14000 Caen, France.",
"collective": null,
"firstname": "Gandhi",
"initials": "G",
"lastname": "Damaj"
},
{
"affiliation": "Registry of Hematological Malignancies of Caen, Caen University Hospital, 14000 Caen, France.",
"collective": null,
"firstname": "Xavier",
"initials": "X",
"lastname": "Troussard"
},
{
"affiliation": "Clinical Hematology Unit, Caen University Hospital, 14000 Caen, France.",
"collective": null,
"firstname": "Alain",
"initials": "A",
"lastname": "Monnereau"
},
{
"affiliation": "Breast and Gynecologic Cancer Registry of Côte d'Or, Georges François Leclerc Comprehensive Cancer Centre, 21000 Dijon, France.\nClinical Hematology Unit, Dijon Bourgogne University Hospital, 21000 Dijon, France.",
"collective": null,
"firstname": "Sandrine Tienhan",
"initials": "ST",
"lastname": "Dabakuyo-Yonli"
},
{
"affiliation": "Registry of Hematological Malignancies of Côte d'Or, Dijon-Bourgogne University Hospital, 21000 Dijon, France.\nINSERM, UMR1231, Bourgogne Franche-Comté University, 21000 Dijon, France.",
"collective": null,
"firstname": "Marc",
"initials": "M",
"lastname": "Maynadie"
}
] |
Cancers
| null |
40002304
|
Health-Related Quality of Life in Long-Term Survivors of Non-Hodgkin Lymphoma: A French Population-Based Study.
| null | null | null | null | null | null |
null |
Copyright © 2025 Elsevier B.V. All rights reserved.
|
10.1016/j.chroma.2025.465658
| null |
[
"Blood-brain barrier",
"Chiral separation",
"Evodiamine",
"Stereoselectivity"
] |
2025-01-15
|
Evodiamine, a chiral quinazoline alkaloid in the traditional Chinese medicine Evodiae fructus, exhibited efficacy for CNS diseases. In this study, the pure enantiomers of evodiamine were prepared in large quantities via chemical resolution. Their structures were elucidated by MS, NMR and ECD. The optical purity was determined to be as high as 99.8 %. The differences of the enantiomers in protective effect against neuronal cell injury were evaluated using MTT assay. Notably, R-(-)-evodiamine showed better neuroprotection effects against H
|
[
{
"affiliation": "School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, PR China. Electronic address: [email protected].",
"collective": null,
"firstname": "Ming",
"initials": "M",
"lastname": "Chen"
},
{
"affiliation": "School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, PR China. Electronic address: [email protected].",
"collective": null,
"firstname": "Yiwen",
"initials": "Y",
"lastname": "Zhang"
},
{
"affiliation": "School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, PR China. Electronic address: [email protected].",
"collective": null,
"firstname": "Xuhua",
"initials": "X",
"lastname": "Qi"
},
{
"affiliation": "Shenyang No.40 High school, Shenyang 110034, PR China. Electronic address: [email protected].",
"collective": null,
"firstname": "Mingyue",
"initials": "M",
"lastname": "Ma"
},
{
"affiliation": "School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, PR China. Electronic address: [email protected].",
"collective": null,
"firstname": "Yan",
"initials": "Y",
"lastname": "Cui"
}
] |
Journal of chromatography. A
| null |
39808905
|
Stereoselectivity of evodiamine enantiomers in neuroprotective activity, pharmacokinetics and the ability across the blood-brain barrier.
| null | null | null | null | null | null |
null |
Copyright © 2024 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. All Rights Reserved.
|
10.1097/CCM.0000000000006437
| null |
[] |
2024-10-04
|
Neurocritically ill patients are at high risk for developing delirium, which can worsen the long-term outcomes of this vulnerable population. However, existing delirium assessment tools do not account for neurologic deficits that often interfere with conventional testing and are therefore unreliable in neurocritically ill patients. We aimed to determine the accuracy and predictive validity of the Fluctuating Mental Status Evaluation (FMSE), a novel delirium screening tool developed specifically for neurocritically ill patients.
Prospective validation study.
Neurocritical care unit at an academic medical center.
One hundred thirty-nine neurocritically ill stroke patients (mean age, 63.9 [ sd , 15.9], median National Institutes of Health Stroke Scale score 11 [interquartile range, 2-17]).
None.
Expert raters performed daily Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition-based delirium assessments, while paired FMSE assessments were performed by trained clinicians. We analyzed 717 total noncomatose days of paired assessments, of which 52% ( n = 373) were rated by experts as days with delirium; 53% of subjects were delirious during one or more days. Compared with expert ratings, the overall accuracy of the FMSE was high (area under the curve [AUC], 0.85; 95% CI, 0.82-0.87). FMSE scores greater than or equal to 1 had 86% sensitivity and 74% specificity on a per-assessment basis, while scores greater than or equal to 2 had 70% sensitivity and 88% specificity. Accuracy remained high in patients with aphasia (FMSE ≥ 1: 82% sensitivity, 64% specificity; FMSE ≥ 2: 64% sensitivity, 84% specificity) and those with decreased arousal (FMSE ≥ 1: 87% sensitivity, 77% specificity; FMSE ≥ 2: 71% sensitivity, 90% specificity). Positive FMSE assessments also had excellent accuracy when predicting functional outcomes at discharge (AUC, 0.86 [95% CI, 0.79-0.93]) and 3 months (AUC, 0.85 [95% CI, 0.78-0.92]).
In this validation study, we found that the FMSE was an accurate delirium screening tool in neurocritically ill stroke patients. FMSE scores greater than or equal to 1 indicate "possible" delirium and should be used when prioritizing sensitivity, whereas scores greater than or equal to 2 indicate "probable" delirium and should be used when prioritizing specificity.
|
[
{
"affiliation": "Center for Research, Investigation, and Systems Modeling of Acute Illness (CRISMA), University of Pittsburgh School of Medicine, Pittsburgh, PA.\nDepartment of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA.\nDepartment of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA.",
"collective": null,
"firstname": "Michael E",
"initials": "ME",
"lastname": "Reznik"
},
{
"affiliation": "Department of Psychiatry and Human Behavior, Brown University, Alpert Medical School, Providence, RI.",
"collective": null,
"firstname": "Seth A",
"initials": "SA",
"lastname": "Margolis"
},
{
"affiliation": "Department of Neurology, Brown University, Alpert Medical School, Providence, RI.",
"collective": null,
"firstname": "Nicholas",
"initials": "N",
"lastname": "Andrews"
},
{
"affiliation": "Department of Neurology, Brown University, Alpert Medical School, Providence, RI.",
"collective": null,
"firstname": "Colin",
"initials": "C",
"lastname": "Basso"
},
{
"affiliation": "Department of Neurology, Brown University, Alpert Medical School, Providence, RI.",
"collective": null,
"firstname": "Noa",
"initials": "N",
"lastname": "Mintz"
},
{
"affiliation": "Department of Neurology, Brown University, Alpert Medical School, Providence, RI.",
"collective": null,
"firstname": "Sean",
"initials": "S",
"lastname": "Varga"
},
{
"affiliation": "Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA.",
"collective": null,
"firstname": "Beth E",
"initials": "BE",
"lastname": "Snitz"
},
{
"affiliation": "Center for Research, Investigation, and Systems Modeling of Acute Illness (CRISMA), University of Pittsburgh School of Medicine, Pittsburgh, PA.\nDepartment of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA.",
"collective": null,
"firstname": "Timothy D",
"initials": "TD",
"lastname": "Girard"
},
{
"affiliation": "Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA.",
"collective": null,
"firstname": "Lori A",
"initials": "LA",
"lastname": "Shutter"
},
{
"affiliation": "Critical Illness, Brain Dysfunction, and Survivorship (CIBS) Center, Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.\nTennessee Valley Veterans Affairs Geriatric Research Education Clinical Center (GRECC), Nashville, TN.",
"collective": null,
"firstname": "E Wesley",
"initials": "EW",
"lastname": "Ely"
},
{
"affiliation": "Department of Psychiatry and Human Behavior, Brown University, Alpert Medical School, Providence, RI.\nDepartment of Neurology, Brown University, Alpert Medical School, Providence, RI.",
"collective": null,
"firstname": "Richard N",
"initials": "RN",
"lastname": "Jones"
}
] |
Critical care medicine
| null |
39365697
|
Validating the Fluctuating Mental Status Evaluation in Neurocritically Ill Patients With Acute Stroke.
| null | null | null | null | null | null |
null | null |
10.3390/ijms20153622
10.1016/j.addr.2018.04.017
10.1002/jor.23499
10.1007/s007760100006
10.1097/00007632-199506000-00022
10.1007/s10495-013-0839-1
10.1371/journal.pone.0049995
10.1016/j.spinee.2012.12.003
10.1016/j.copbio.2013.04.012
10.5966/sctm.2016-0033
10.1097/01.brs.0000174530.88585.32
10.1016/j.addr.2014.08.008
10.22203/eCM.v025a01
10.1111/j.1533-2500.2007.00171.x
10.1111/j.1469-7580.2012.01521.x
10.1111/joa.12258
10.1097/BRS.0b013e31818e5ddd
10.1186/ar629
10.1002/art.20236
10.1016/j.spinee.2004.07.010
10.1016/S0945-053X(01)00184-6
10.1097/MD.0000000000009149
10.1093/rheumatology/ken396
10.1002/jlb.67.2.149
10.1016/0142-9612(96)84936-2
10.3174/ajnr.A4173
10.1016/j.jpain.2017.06.002
10.1089/ten.teb.2009.0451
10.2106/JBJS.M.00141
10.1111/j.1469-7580.2012.01551.x
10.1097/BSD.0000000000000328
10.1243/0954411001535219
10.1080/17453670610045902
10.3109/03008207.2014.942419
10.1097/01.brs.0000146101.53784.b1
10.1097/01.brs.0000146499.97948.52
10.1016/j.amjmed.2009.05.028
10.22203/eCM.v020a25
10.1002/jbm.b.32712
10.1016/j.spinee.2004.12.004
10.3171/SPI/2008/8/2/115
10.1016/j.spinee.2005.02.021
10.1002/term.2750
10.2217/rme-2016-0069
10.1186/s40824-017-0106-6
10.1515/bmc-2018-0003
10.1126/scitranslmed.aau0670
10.1016/j.joca.2015.08.014
10.1007/s00586-011-1697-6
10.1016/J.ENG.2017.01.010
10.1155/2014/489128
10.1016/j.biomaterials.2007.07.028
10.1089/ten.teb.2013.0537
10.1016/j.jbiomech.2015.10.015
10.1016/j.clinbiochem.2009.06.017
10.1097/BRS.0b013e31823c8603
10.1016/j.spinee.2006.11.006
10.1080/03008207.2017.1282951
10.1111/j.1745-7270.2006.00230.x
10.3340/jkns.2008.44.5.327
10.1097/01.brs.0000263369.95182.19
10.1097/01.brs.0000176319.78887.64
10.1016/j.spinee.2007.04.021
10.1097/00007632-200206150-00014
10.1097/01.brs.0000148002.68656.4d
10.1097/01.brs.0000206358.66412.7b
10.1002/jor.20339
10.1186/s13075-015-0625-2
10.1002/term.2111
10.1097/01.brs.0000248428.22823.86
10.1159/000369670
10.1186/1746-6148-10-3
10.1097/01.BRS.0000107231.67854.9F
10.1002/art.27733
10.1155/2015/427138
10.1016/j.joca.2013.07.017
10.1007/s00264-014-2664-8
10.1016/j.addr.2014.06.009
10.1007/s00586-006-0149-1
10.1007/s00167-012-1977-7
10.22203/eCM.v027sa02
10.1002/jor.21534
10.3171/2012.10.SPINE12512
10.1016/j.jot.2017.03.003
10.1002/jor.21036
10.1016/j.actbio.2018.03.019
10.1097/01.brs.0000146462.92171.7f
10.1016/j.bioeng.2006.07.002
10.1002/jor.23268
10.1016/j.jot.2017.02.002
10.1097/01.brs.0000184365.28481.e3
10.1097/BRS.0b013e3181d10401
10.1097/BRS.0b013e3181a54157
10.1016/j.ijsu.2016.02.045
10.1634/stemcells.2007-0374
10.1177/2050312118761674
10.1055/s-0036-1583174
10.1007/s00586-011-2026-9
10.1038/srep45623
10.1615/CritRevEukarGeneExpr.v21.i1.30
10.22203/eCM.v030a10
10.1002/jor.21147
10.1002/adma.200501612
10.1155/2018/4368910
10.1016/j.actbio.2017.01.036
10.1002/jor.23351
10.1089/ten.tea.2008.0215
10.1016/j.biomaterials.2013.08.072
10.1177/0885328213515034
10.1371/journal.pone.0185716
10.1016/j.actbio.2018.08.004
10.1007/s00264-018-4245-8
| null |
[
"intervertebral disc",
"nucleus pulposus",
"repair",
"replacement",
"scaffold"
] |
2019-07-28
|
Chronic back pain is a common disability, which is often accredited to intervertebral disc degeneration. Gold standard interventions such as spinal fusion, which are mainly designed to mechanically seal the defect, frequently fail to restore the native biomechanics. Moreover, artificial implants have limited success as a repair strategy, as they do not alter the underlying disease and fail to promote tissue integration and subsequent native biomechanics. The reported high rates of spinal fusion and artificial disc implant failure have pushed intervertebral disc degeneration research in recent years towards repair strategies. Intervertebral disc repair utilizing principles of tissue engineering should theoretically be successful, overcoming the inadequacies of artificial implants. For instance, advances in the development of scaffolds aided with cells and growth factors have opened up new possibilities for repair strategies. However, none has reached the stage of clinical trials in humans. In this review, we describe the hitches encountered in the musculoskeletal field and summarize recent advances in designing tissue-engineered constructs for promoting nucleus pulposus repair. Additionally, the review focuses on the effect of biomaterial aided with cells and growth factors on achieving effective functional reparative potency, highlighting the ways to enhance the efficacy of these treatments.
|
[
{
"affiliation": "Siegfried Weller Institute for Trauma Research at the BG Unfallklinik Tübingen, Eberhard Karls Universität Tübingen, Schnarrenbergstrasse 95, 72076 Tübingen, Germany.",
"collective": null,
"firstname": "Gauri",
"initials": "G",
"lastname": "Tendulkar"
},
{
"affiliation": "Siegfried Weller Institute for Trauma Research at the BG Unfallklinik Tübingen, Eberhard Karls Universität Tübingen, Schnarrenbergstrasse 95, 72076 Tübingen, Germany.",
"collective": null,
"firstname": "Tao",
"initials": "T",
"lastname": "Chen"
},
{
"affiliation": "Siegfried Weller Institute for Trauma Research at the BG Unfallklinik Tübingen, Eberhard Karls Universität Tübingen, Schnarrenbergstrasse 95, 72076 Tübingen, Germany.",
"collective": null,
"firstname": "Sabrina",
"initials": "S",
"lastname": "Ehnert"
},
{
"affiliation": "Siegfried Weller Institute for Trauma Research at the BG Unfallklinik Tübingen, Eberhard Karls Universität Tübingen, Schnarrenbergstrasse 95, 72076 Tübingen, Germany.",
"collective": null,
"firstname": "Hans-Peter",
"initials": "HP",
"lastname": "Kaps"
},
{
"affiliation": "Siegfried Weller Institute for Trauma Research at the BG Unfallklinik Tübingen, Eberhard Karls Universität Tübingen, Schnarrenbergstrasse 95, 72076 Tübingen, Germany. [email protected].",
"collective": null,
"firstname": "Andreas K",
"initials": "AK",
"lastname": "Nüssler"
}
] |
International journal of molecular sciences
| null |
31344903
29705378
28114734
11793173
7660243
23512131
23185509
23537454
23773764
28297581
16103829
25174310
23283636
18211591
22686699
25424497
19127156
12723977
16595436
15077255
15541661
11827789
29390319
18854342
10670574
8799500
25430861
28652204
19903086
23783211
22881295
26836484
23082846
10718048
16752278
25000273
15564918
15564919
20102998
20954128
22566484
16363077
18248282
25050691
16291129
30095863
27586197
29085662
29779014
30463917
26342641
21279392
17669487
24168395
26549765
24250727
19563795
22037529
18455111
28102712
17091194
19119470
17495773
16135982
18082466
12065981
15626976
16582847
17205567
26013758
26612824
17139221
25547527
24387033
14722406
20812336
26583105
26564465
23933379
25653173
24993611
16865380
22476522
24802611
21866573
23140128
29662798
19953600
29555463
15564911
16963315
27104885
29662795
28535552
16261113
20890267
19934809
26898133
17656642
29568524
28451504
21953383
28358123
21967331
26388616
20839317
28088667
27340938
18707229
24050877
24327349
29053719
30092378
30498908
|
Intervertebral Disc Nucleus Repair: Hype or Hope?
| null | null | null | null | null | null |
null |
Copyright © 2024 American Pharmacists Association. Published by Elsevier Inc. All rights reserved.
|
10.1016/j.xphs.2024.04.003
| null |
[
"Compaction",
"Drug effect(s)",
"Formulation",
"Granulation",
"Powder technology",
"Simulation",
"Solid dosage form(s)"
] |
2024-04-13
|
Roll compaction (RC) is a cost-effective dry granulation method, widely implemented in the pharmaceutical industry. In early formulation development however, when the material availability is limited, being able to predict the most important parameters in RC, like gap width and specific compaction force (SCF), to obtain a target ribbon solid fraction (SF) would significantly improve the formulation development efficiency as it would avoid the need of performing experiments on the roller compactor itself. However, at the present state of things, experiments on RC mechanical simulators present an overestimation of the target SF, when compared to roller compactor SF values. Although numerous correction approaches have been developed to improve the predictive performance of different mathematical models applied to the simulation experimental results, no study has collected a database wide enough to demonstrate the validity of a correction factor that allows to accurately simulate the compaction behavior of multicomponent mixtures. Here, 25 different formulations at 40 % drug load are compacted at different SCFs, both on a RC mimicking device (Styl'One Evolution) and on an actual roller compactor (Gerteis Mini-Pactor): following a similar approach as Reimer et al. and implementing a simplified version of the Johanson's mathematical model, 4 different correction factors are calculated, depending on how their material properties and pressure dependencies are considered. In conclusion, one correction factor is identified as the optimal trade-off between the SF prediction accuracy on the Gerteis Mini-Pactor and its applicability to a wide range of formulations, as it is independent of the material properties. This finding is particularly relevant when applied to scale-up to this specific roller compactor or early development processes of new formulations that have not been mechanically characterized yet.
|
[
{
"affiliation": "F. Hoffmann-La Roche AG, Dept. PTDC-F Pharmaceutical R&D, Grenzacherstrasse 124, 4070 Basel, Switzerland.",
"collective": null,
"firstname": "Fabia",
"initials": "F",
"lastname": "Arpago"
},
{
"affiliation": "F. Hoffmann-La Roche AG, Dept. PTDC-F Pharmaceutical R&D, Grenzacherstrasse 124, 4070 Basel, Switzerland. Electronic address: [email protected].",
"collective": null,
"firstname": "Agostino",
"initials": "A",
"lastname": "Dall'Ara"
}
] |
Journal of pharmaceutical sciences
| null |
38608725
|
Modeling of Styl'One Evolution Correction Factors for Multicomponent Mixtures Scaling-up to Roller Compaction.
| null | null | null | null | null | null |
null |
© 2024 The Authors.
|
10.1016/j.gastha.2023.12.008
| null |
[
"Abdominal Pain",
"Endoscopy",
"Hemangioma",
"Sigmoid Colon"
] |
2024-08-12
|
Hemangiomas in the gastrointestinal tract are extremely rare, benign vascular tumors, known for their associated complication of bleeding. They are usually difficult to diagnose, despite the characteristic definition of radiolucent phleboliths on radiology and purplish, tannish brown nodule or polyp on endoscopy. Surgical resection is the treatment of choice. We describe a rare case of sigmoid colon cavernous hemangioma in a 49-year-old male who underwent colonoscopy for lower abdominal pain and revealed a large pedunculated polyp in the sigmoid colon measuring 1.7 cm in diameter. The hemangioma was completely resected endoscopically via hot snare with a favorable outcome.
|
[
{
"affiliation": "Internal Medicine Department, King Hamad University Hospital, Busaiteen, Kingdom of Bahrain.",
"collective": null,
"firstname": "Noora",
"initials": "N",
"lastname": "Al-Khater"
},
{
"affiliation": "Internal Medicine Department, King Hamad University Hospital, Busaiteen, Kingdom of Bahrain.",
"collective": null,
"firstname": "Mohamed",
"initials": "M",
"lastname": "Mohamed"
},
{
"affiliation": "Internal Medicine Department, King Hamad University Hospital, Busaiteen, Kingdom of Bahrain.",
"collective": null,
"firstname": "Afra",
"initials": "A",
"lastname": "Juma"
},
{
"affiliation": "Gastroenterology and Hepatology Department, King Hamad University Hospital, Busaiteen, Kingdom of Bahrain.",
"collective": null,
"firstname": "Faisal",
"initials": "F",
"lastname": "Abubaker"
},
{
"affiliation": "Pathology Department, King Hamad University Hospital, Busaiteen, Kingdom of Bahrain.",
"collective": null,
"firstname": "Sameer",
"initials": "S",
"lastname": "Ansari"
}
] |
Gastro hep advances
| null |
39131147
20011316
31616236
22942801
34256425
11641173
7215080
30978732
|
Endoscopic Resection of a Cavernous Hemangioma in the Sigmoid Colon: A Case Report.
| null | null | null | null | null | null |
Venous diethylene glycol poisoning is characterized by oliguric acute renal failure, metabolic acidosis, digestive symptoms, nervous system impairment, and a high probability of anemia and WBC proliferation. Mortality is high. Correlative factors include preexisting severe liver disease, renal disease, and infection.
| null |
10.3748/wjg.14.3236
|
Of the 64 patients who received armillarisin-A, 15 were found to have DEG poisoning. Twelve poisoned patients died. After a mean of 5 d, the poisoned patients displayed acute renal failure. Metabolic acidosis occurred in 13 cases. BUN, Cr, and CO2 values were significantly elevated and exacerbation of digestive tract symptoms and/or symptom was noted in 11 cases. Neurological system impairment was observed in 10 cases after 2 wk. Compared to the 49 non-poisoned patients, the poisoned patients exhibited significantly lower RBC and Hb values and higher WBC count. Renal biopsy from the poisoned patients revealed acute tubular necrosis and interstitial nephritis. Significant differences in preexisting severe hepatitis, ascites, renal disease, and diuretic therapy were found between groups. Prior to diethylene glycol injections, the mean values for neutral granular cells, BUN, Cr, calcium and phosphorous ions differed significantly between groups.
|
[] |
2008-05-29
|
To analyze the clinical presentation of venous diethylene glycol (DEG) poisoning in patients with preexisting severe liver disease and factors that correlate with DEG poisoning.
Retrospective chart review was performed to analyze the epidemiology, clinical presentation, hepatorenal functions, hemodynamics and pathological characteristics of 64 patients with severe liver disease who received intravenous armillarisin-A, the solvent of which was DEG. Comparative analyses of correlating factors and causes for poisoning were based on the presence or absence of poisoning.
Of the 64 patients who received armillarisin-A, 15 were found to have DEG poisoning. Twelve poisoned patients died. After a mean of 5 d, the poisoned patients displayed acute renal failure. Metabolic acidosis occurred in 13 cases. BUN, Cr, and CO2 values were significantly elevated and exacerbation of digestive tract symptoms and/or symptom was noted in 11 cases. Neurological system impairment was observed in 10 cases after 2 wk. Compared to the 49 non-poisoned patients, the poisoned patients exhibited significantly lower RBC and Hb values and higher WBC count. Renal biopsy from the poisoned patients revealed acute tubular necrosis and interstitial nephritis. Significant differences in preexisting severe hepatitis, ascites, renal disease, and diuretic therapy were found between groups. Prior to diethylene glycol injections, the mean values for neutral granular cells, BUN, Cr, calcium and phosphorous ions differed significantly between groups.
Venous diethylene glycol poisoning is characterized by oliguric acute renal failure, metabolic acidosis, digestive symptoms, nervous system impairment, and a high probability of anemia and WBC proliferation. Mortality is high. Correlative factors include preexisting severe liver disease, renal disease, and infection.
|
[
{
"affiliation": "Department of Infectious Diseases, Third Affiliated Hospital of Sun Yet-Sen University, Tianhe Area, 600 Tianhe Road, Guangzhou 510060, Guangdong Province, China.",
"collective": null,
"firstname": "Bing-Liang",
"initials": "BL",
"lastname": "Lin"
},
{
"affiliation": null,
"collective": null,
"firstname": "Zhi-Xin",
"initials": "ZX",
"lastname": "Zhao"
},
{
"affiliation": null,
"collective": null,
"firstname": "Yu-Tian",
"initials": "YT",
"lastname": "Chong"
},
{
"affiliation": null,
"collective": null,
"firstname": "Jian-Guo",
"initials": "JG",
"lastname": "Li"
},
{
"affiliation": null,
"collective": null,
"firstname": "Xing",
"initials": "X",
"lastname": "Zuo"
},
{
"affiliation": null,
"collective": null,
"firstname": "Yu",
"initials": "Y",
"lastname": "Tao"
},
{
"affiliation": null,
"collective": null,
"firstname": "Tan-Qi",
"initials": "TQ",
"lastname": "Lou"
},
{
"affiliation": null,
"collective": null,
"firstname": "Zhi-Liang",
"initials": "ZL",
"lastname": "Gao"
}
] |
World journal of gastroenterology
| null |
18506932
|
Venous diethylene glycol poisoning in patients with preexisting severe liver disease in China.
| null | null | null | null | null | null |
null |
© 2025 The Authors. Published by American Chemical Society.
|
10.1021/acsomega.5c00013
10.1016/j.pmatsci.2022.100977
10.1002/pola.23870
10.1016/j.cej.2018.09.020
10.1021/acsmaterialslett.1c00277
10.1002/pol.20210134
10.1039/D0PY00928H
10.1002/pc.26518
10.1016/j.matpr.2020.09.742
10.1134/S0965545X19040096
10.1021/ma048465n
10.1002/app.21303
10.1016/j.polymer.2014.12.042
10.1016/j.compscitech.2015.10.023
10.1016/j.matchemphys.2013.05.018
10.1002/app.48471
10.1016/j.polymer.2015.04.002
10.1016/j.polymer.2009.05.006
10.1016/j.matdes.2010.11.034
10.1007/s10853-011-5724-0
10.1016/j.carbon.2013.03.050
10.1016/j.compscitech.2011.07.016
10.3144/expresspolymlett.2008.6
10.1021/nn9010472
10.1016/j.compositesa.2014.04.023
10.1016/j.matdes.2014.10.047
10.1016/j.compscitech.2005.04.021
10.1016/j.carbon.2007.11.051
10.3144/expresspolymlett.2014.51
10.1016/j.polymdegradstab.2016.03.021
10.1007/s10853-012-6803-6
10.1016/j.carbon.2012.07.021
10.1016/j.eurpolymj.2014.09.022
10.1016/j.carbon.2011.11.001
10.1016/j.compscitech.2007.11.001
10.1016/j.compositesb.2012.01.070
10.1016/j.jcis.2017.01.013
10.1002/smll.200901957
10.1088/0957-4484/17/6/003
10.1016/j.compscitech.2004.04.002
10.1016/j.compositesb.2019.04.015
10.1016/j.carbon.2019.01.063
10.1021/acsami.0c12110
10.1016/j.polymer.2019.121988
10.1021/acsomega.6b00517
10.1016/j.compositesa.2021.106419
10.1016/j.compscitech.2015.08.010
10.1039/C4RA11120F
10.1002/pat.4948
10.1007/s10904-019-01340-8
10.1080/25740881.2021.1959929
10.1016/j.rinp.2016.10.013
10.1177/0954008320907123
10.1016/j.compscitech.2022.109815
10.1016/j.polymertesting.2021.107275
10.3390/polym14010103
10.1016/j.matlet.2024.136206
10.1016/j.dib.2024.110169
10.1016/j.diamond.2020.108101
10.1016/j.cpc.2021.108171
10.1021/acs.macromol.1c01813
10.1021/acs.jpcb.8b01127
10.1021/acs.jcim.4c00730
10.1021/acs.macromol.0c02012
10.1002/polb.24539
10.1021/acsapm.1c01024
10.26434/chemrxiv-2024-9tqz2
10.1016/0026-265X(90)90027-3
10.1021/ma011360p
10.1021/ma901244d
10.1016/j.polymer.2016.05.059
10.1061/(ASCE)0893-1321(2008)21:3(162)
10.1002/pc.24137
10.1061/(ASCE)0893-1321(2007)20:2(75)
10.1021/acs.jpca.8b03826
10.1016/j.polymer.2010.10.033
10.1021/acs.jpcc.0c03509
10.1002/pol.20200442
10.1021/acs.langmuir.3c00262
10.1021/ma00130a018
10.1016/j.matt.2021.01.001
10.1016/j.pmatsci.2020.100710
10.1016/j.compositesb.2017.11.028
| null |
[] |
2025-04-21
|
Due to their excellent mechanical properties, epoxy composites are widely used in low-density applications. However, the brittle epoxy matrix often serves as the principal failure point. Matrix enhancements can be achieved by optimizing polymer combinations to maximize intermolecular interactions or by introducing fillers. While nanofillers such as clay, rubber, carbon nanotubes, and nanoplatelets enhance mechanical properties, they can lead to issues like agglomeration, voids, and poor load transfer. Quantum dots, being the smallest nanofillers, offer higher dispersion and the potential to promote intermolecular interactions, enhancing stiffness, strength, and toughness simultaneously. This study employed molecular dynamics simulations to design graphene quantum dot (GQD) reinforced epoxy nanocomposites. By functionalizing GQDs with oxygen-based groups-hydroxyl, epoxide, carboxyl, and mixed chemistries-their effects on the mechanical properties of nanocomposites were systematically evaluated. Results show that hydroxyl-functionalized GQDs provide optimal performance, increasing stiffness and yield strength by 18.4 and 56.1%, respectively. Structural analysis reveals that these GQDs promote a closely packed molecular configuration, resulting in reduced free volume.
|
[
{
"affiliation": "Department of Chemical and Materials Engineering, San Jose State University, San Jose, California 95192, United States.",
"collective": null,
"firstname": "Prathamesh P",
"initials": "PP",
"lastname": "Deshpande"
},
{
"affiliation": "Department of Chemical and Materials Engineering, San Jose State University, San Jose, California 95192, United States.",
"collective": null,
"firstname": "Robert",
"initials": "R",
"lastname": "Chan-Jobe"
},
{
"affiliation": "Department of Mechanical Engineering-Engineering Mechanics, Michigan Technological University, Houghton, Michigan 49931, United States.",
"collective": null,
"firstname": "Josh",
"initials": "J",
"lastname": "Kemppainen"
},
{
"affiliation": "Department of Mechanical Engineering-Engineering Mechanics, Michigan Technological University, Houghton, Michigan 49931, United States.",
"collective": null,
"firstname": "Gregory M",
"initials": "GM",
"lastname": "Odegard"
},
{
"affiliation": "Department of Mechanical Engineering and Engineering Science, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, United States.",
"collective": null,
"firstname": "Ozgur",
"initials": "O",
"lastname": "Keles"
}
] |
ACS omega
| null |
40256520
19957928
28088122
20183814
26558557
32877159
31909111
31457728
35012124
38389955
38389955
39261455
29518340
38926930
31806922
38926930
29996044
37027214
|
Optimizing Epoxy Nanocomposites with Oxidized Graphene Quantum Dots for Superior Mechanical Performance: A Molecular Dynamics Approach.
| null | null | null | null | null | null |
null |
Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.
|
10.1097/MD.0000000000036796
| null |
[] |
2024-01-11
|
Cancer with unknown primary site is a kind of disease that is difficult to deal with clinically, accounting for 2% to 9% of all newly diagnosed cancer cases. Here, we report such a case with pelvic metastatic squamous cell carcinoma of an unknown primary site and review the relevant literature.
A 43-year-old Chinese female patient was referred to our hospital and initially diagnosed as "malignant tumor of right adnexal area?, obstruction of right ureter, secondary hydronephrosis".
Thereafter cytoreductive surgery was performed which included a total hysterectomy, left adnexectomy, partial omentum resection, pelvic lymph node dissection, and para-aortic lymph node dissection. The primary lesion could not be identified by supplementary examination and postoperative pathology. The patient was diagnosed as pelvic metastatic squamous cell carcinoma whose primary site was unknown. To prevent a recurrence, we administered adjuvant chemotherapy for the patient.
The patient was followed up after treatment, complete remission has been maintained for 72 months, and no recurrence or metastasis has been found.
Our case demonstrates that surgery combined with chemotherapy could be helpful for pelvic metastatic squamous cell carcinoma of unknown primary site.
|
[
{
"affiliation": "Department of Gynecological Oncology, Jiangxi Maternal and Child Health Hospital, Nanchang, Jiangxi, People's Republic of China.",
"collective": null,
"firstname": "Qi-Zhou",
"initials": "QZ",
"lastname": "Zhu"
},
{
"affiliation": "Medical Department, Jiangxi Maternal and Child Health Hospital, Nanchang, Jiangxi, People's Republic of China.",
"collective": null,
"firstname": "Hui-Juan",
"initials": "HJ",
"lastname": "Li"
},
{
"affiliation": "Department of Gynecological Oncology, Jiangxi Maternal and Child Health Hospital, Nanchang, Jiangxi, People's Republic of China.",
"collective": null,
"firstname": "Yuan-Qiang",
"initials": "YQ",
"lastname": "Li"
},
{
"affiliation": "Department of Pathology, Jiangxi Maternal and Child Health Hospital, Nanchang, Jiangxi, People's Republic of China.",
"collective": null,
"firstname": "Xiao-Hong",
"initials": "XH",
"lastname": "Yu"
},
{
"affiliation": "Department of Gynecological Oncology, Jiangxi Maternal and Child Health Hospital, Nanchang, Jiangxi, People's Republic of China.",
"collective": null,
"firstname": "Kuan-Yong",
"initials": "KY",
"lastname": "Shu"
}
] |
Medicine
| null |
38206704
|
Pelvic metastatic squamous cell carcinoma of unknown primary site: A case report and brief literature review.
| null | null | null | null | null | null |
Early PPV was superior to initial intravitreal antibiotics alone as it required fewer additional treatments to control infection. Visual outcome was similar between early PPV and initial intravitreal antibiotics alone despite high number of poor presenting VA of light-perception in early PPV group. Streptococcal infection and retinal detachment were major poor prognostic factors for vision.
|
© 2022. The Author(s), under exclusive licence to The Royal College of Ophthalmologists.
|
10.1038/s41433-022-02347-1
10.1136/bjo.2008.147520
10.1016/j.jcrs.2011.06.019
10.1016/j.ophtha.2016.02.019
10.1007/s10384-017-0545-6
10.3349/ymj.2019.60.5.467
10.1016/j.ophtha.2019.08.026
10.1007/s00417-005-0082-8
10.1038/sj.eye.6702987
10.1007/s00417-012-1926-7
10.1016/j.jcma.2017.05.001
10.1097/ICU.0000000000000727
10.1016/j.survophthal.2018.02.003
10.1001/archopht.1995.01100120009001
10.1136/bmjophth-2019-000423
10.1097/IAE.0b013e3181953a31
10.1097/IAE.0000000000002856
10.1111/ceo.13077
10.1016/j.ophtha.2005.01.050
10.1001/jamaophthalmol.2013.4242
10.1016/S0002-9394(14)71959-2
10.1016/j.ophtha.2007.06.006
10.1016/j.jcrs.2006.10.022
10.1016/j.jcrs.2012.10.037
10.1016/j.ajo.2016.11.006
10.1016/j.ajo.2013.12.026
10.1001/archopht.118.12.1661
10.1136/bjophthalmol-2015-307359
|
Out of 41,411 cataract operations, 22 eyes developed acute postoperative endophthalmitis. Presenting VA was hand-movement or worse in 72.7%. The most common organisms were Staphylococcus (40.9%), Streptococcus (13.6%) and Enterococcus (13.6%). 22.7% of eyes had good final VA ≥ 20/30 and 27.3% had poor final VA < 20/400. Early PPV group had significantly lower rate of requiring additional treatments to control infection (25% versus 80%, P = 0.030), higher rate of retinal detachment (25% versus 0%, P = 0.221) and similar final logMAR VA (1.08 ± 1.08 versus 0.80 ± 0.80, P = 0.489) compared to IVA. Multivariate linear regression analysis showed that worse final VA was significantly associated with Streptococcus (ß = 1.92, P = 0.007) and retinal detachment (ß = 1.72, P = 0.005) but not with early PPV (P = 0.225).
|
[] |
2022-12-14
|
To evaluate result of early pars plana vitrectomy (PPV) within 24 hours of presentation for acute postoperative endophthalmitis after cataract operation, and to determine factors that predict visual outcome.
Consecutive patients who developed acute postoperative endophthalmitis within 6 weeks after cataract operation were reviewed. Patients were divided into two groups for analysis: (1) those receiving PPV within 24 hours of presentation (early PPV group), and (2) those receiving initial intravitreal antibiotics only without PPV within 24 hours of presentation (IVA group).
Out of 41,411 cataract operations, 22 eyes developed acute postoperative endophthalmitis. Presenting VA was hand-movement or worse in 72.7%. The most common organisms were Staphylococcus (40.9%), Streptococcus (13.6%) and Enterococcus (13.6%). 22.7% of eyes had good final VA ≥ 20/30 and 27.3% had poor final VA < 20/400. Early PPV group had significantly lower rate of requiring additional treatments to control infection (25% versus 80%, P = 0.030), higher rate of retinal detachment (25% versus 0%, P = 0.221) and similar final logMAR VA (1.08 ± 1.08 versus 0.80 ± 0.80, P = 0.489) compared to IVA. Multivariate linear regression analysis showed that worse final VA was significantly associated with Streptococcus (ß = 1.92, P = 0.007) and retinal detachment (ß = 1.72, P = 0.005) but not with early PPV (P = 0.225).
Early PPV was superior to initial intravitreal antibiotics alone as it required fewer additional treatments to control infection. Visual outcome was similar between early PPV and initial intravitreal antibiotics alone despite high number of poor presenting VA of light-perception in early PPV group. Streptococcal infection and retinal detachment were major poor prognostic factors for vision.
|
[
{
"affiliation": "Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong, China. [email protected].\nDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China. [email protected].",
"collective": null,
"firstname": "Lawrence Pui Leung",
"initials": "LPL",
"lastname": "Iu"
},
{
"affiliation": "Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong, China.\nDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.",
"collective": null,
"firstname": "Ho Yan",
"initials": "HY",
"lastname": "Chan"
},
{
"affiliation": "Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong, China.\nDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.",
"collective": null,
"firstname": "Gabriel Ka Hin",
"initials": "GKH",
"lastname": "Li"
},
{
"affiliation": "Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong, China.\nDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.",
"collective": null,
"firstname": "Mary",
"initials": "M",
"lastname": "Ho"
},
{
"affiliation": "Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong, China.\nDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.",
"collective": null,
"firstname": "Andrew Chun Yue",
"initials": "ACY",
"lastname": "Mak"
},
{
"affiliation": "Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong, China.\nDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.",
"collective": null,
"firstname": "Posey Po Yin",
"initials": "PPY",
"lastname": "Wong"
},
{
"affiliation": "Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong, China.\nDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.",
"collective": null,
"firstname": "Ka Wai",
"initials": "KW",
"lastname": "Kam"
},
{
"affiliation": "Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.",
"collective": null,
"firstname": "Li Jia",
"initials": "LJ",
"lastname": "Chen"
},
{
"affiliation": "Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.",
"collective": null,
"firstname": "Marten",
"initials": "M",
"lastname": "Brelen"
},
{
"affiliation": "Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong, China.\nDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.",
"collective": null,
"firstname": "Alvin Lerrmann",
"initials": "AL",
"lastname": "Young"
}
] |
Eye (London, England)
| null |
36513854
|
Acute postoperative endophthalmitis after cataract operation: result of early vitrectomy within 24 hours of presentation.
| null | null | null | null | null | null |
null |
Copyright by International Society of Lymphology.
| null | null |
[
"Noonan syndrome",
"RIT1",
"indocyanine green lymphography",
"lymphatic malformation",
"lymphedema",
"lymphoscintigraphy",
"magnetic resonance lymphangiography"
] |
2020-11-16
|
L ymphedema is a well-known complication of Noonan syndrome (NS) but the lymphatic malformations in NS are poorly understood. We report clinical, genetic, and imaging information about a boy and girl with NS and late-onset lower extremity lymphedema. A de novo missense mutation of RIT1 (NM_006912.5) c.246T>A, p.Phe82Leu was identified in the girl, who also showed systemic lymphatic hyperplasia and dysfunction. Magnetic resonance lymphangiography (MRL) of the boy clearly demonstrated segmental dilated and hyperplastic lymphatics with impaired transport function in an affected limb and pelvic region. Indocyanine green lymphography (ICGL) showed delayed and partial enhancement of the lymph vessels in the affected limb but no lymph reflux was detected. No causative mutation was identified in the second case. Lymphoscintigraphy (LSG) failed to show lymph vessels in either of the children. Our study showed that MRL is a reliable and accurate test that can be used to demonstrate morpho-logical and functional defects of the lymphatic system. Moreover, ICGL is sufficiently sensitive to determine the functional condition of peripheral lymph vessels. The combined use of imaging modalities can give an accurate diagnosis of complex lymphatic system anomalies in NS and other syndromic diseases.
|
[
{
"affiliation": "Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.",
"collective": null,
"firstname": "N-F",
"initials": "NF",
"lastname": "Liu"
},
{
"affiliation": "Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.",
"collective": null,
"firstname": "M-Z",
"initials": "MZ",
"lastname": "Gao"
}
] |
Lymphology
| null |
33190430
|
Lymphatic system malformations in Noonan syndrome: Two case reports and imaging analysis.
| null | null | null | null | null | null |
null | null |
10.3390/ijms25158090
10.1002/JPER.17-0721
10.1016/j.molmed.2014.11.004
10.1111/jcpe.12942
10.1111/omi.12119
10.1016/j.micpath.2013.05.001
10.1016/j.adaj.2019.07.024
10.1128/IAI.67.3.1227-1237.1999
10.1016/j.molimm.2010.08.009
10.3390/pathogens9040248
10.1128/iai.56.5.1301-1308.1988
10.1128/iai.57.6.1702-1706.1989
10.1371/journal.pone.0018287
10.3389/froh.2022.835902
10.1080/20002297.2018.1487741
10.3389/froh.2021.722495
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10.1016/j.chom.2011.10.006
10.1038/srep04828
10.1371/journal.pone.0134234
10.1038/s41598-017-14260-9
10.1152/physiologyonline.2001.16.3.126
10.1038/35067088
10.1016/j.jnutbio.2020.108383
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10.3390/cells3020476
10.3389/froh.2022.845002
10.1128/JCM.00729-13
10.1128/JB.00554-07
10.1073/pnas.1400586111
10.1128/mBio.00782-16
10.1016/0006-3207(92)91201-3
10.1016/0022-5193(66)90013-0
10.1038/nrmicro928
10.1128/IAI.73.4.1947-1953.2005
10.1128/IAI.02020-06
10.1016/j.kjms.2018.01.014
10.1007/s00335-021-09863-7
10.3390/nu15040826
10.1159/000146256
10.1128/mBio.01249-16
10.1371/journal.pone.0069382
10.1016/j.micinf.2005.01.012
10.1111/j.1365-2249.2006.03260.x
10.1111/j.1399-302X.2005.00245.x
10.1016/j.bone.2009.12.030
10.1111/omi.12034
10.1073/pnas.1905238116
10.1128/microbiolspec.GPP3-0052-2018
10.1099/mic.0.082156-0
10.1016/j.micpath.2018.11.005
10.3390/microorganisms8121852
10.1111/j.1365-2958.2005.04830.x
10.3389/fmicb.2017.00523
10.1007/s00018-012-1070-x
10.1038/s41598-021-04562-4
10.1111/cmi.12299
10.1073/pnas.0809533106
10.1128/IAI.01618-13
10.1016/S1074-7613(01)00151-0
10.1172/JCI17129
10.1152/ajpgi.90516.2008
10.1016/j.bbamem.2008.08.027
10.1007/s00125-007-0791-0
10.2337/db06-1595
10.1136/gutjnl-2016-312580
10.4049/jimmunol.178.7.4641
10.1111/j.1600-0765.2011.01424.x
10.1053/j.gastro.2021.12.288
10.1016/j.micpath.2012.11.004
10.2337/db07-1403
10.1038/s41368-022-00183-3
10.1177/0022034520924633
10.1186/s12864-016-3254-5
10.1111/jcpe.12811
10.1038/s41579-021-00559-y
10.1177/0022034520926126
10.1111/j.1574-695X.2010.00744.x
10.1038/s41419-018-0982-2
10.1128/CMR.00060-18
10.1371/journal.pone.0216165
10.1902/jop.2009.090185
10.1093/femspd/ftaa024
10.7150/jca.15792
10.11138/orl/2017.10.3.229
10.1080/21655979.2021.1889109
10.1111/j.1600-0757.1999.tb00158.x
10.1038/npjbiofilms.2016.18
10.3389/fphar.2021.713595
10.4103/0976-500X.119726
10.3109/08910609409141342
10.1186/1471-2164-11-392
10.1016/j.bbamem.2020.183205
10.1128/IAI.01187-15
10.1016/j.celrep.2017.05.059
10.1038/ismej.2011.41
10.1038/s41587-019-0209-9
10.1093/nar/gks1219
10.1093/nar/gkt1209
10.3402/mehd.v26.27663
10.1038/s41522-020-00160-w
10.1186/s40168-020-00841-w
| null |
[
"A. actinomycetemcomitans",
"Streptococcus gordonii",
"alveolar bone loss",
"periodontitis"
] |
2024-08-10
|
Oral bacteria are implicated not only in oral diseases but also in gut dysbiosis and inflammatory conditions throughout the body. The periodontal pathogen
|
[
{
"affiliation": "Department of Microbiology, Institute of Biomedical Science, University of São Paulo, São Paulo 05508-000, SP, Brazil.\nDepartment of Stomatology, School of Dentistry, University of São Paulo, São Paulo 05508-000, SP, Brazil.",
"collective": null,
"firstname": "Catarina Medeiros",
"initials": "CM",
"lastname": "Rocha"
},
{
"affiliation": "Department of Microbiology, Institute of Biomedical Science, University of São Paulo, São Paulo 05508-000, SP, Brazil.",
"collective": null,
"firstname": "Dione",
"initials": "D",
"lastname": "Kawamoto"
},
{
"affiliation": "Department of Microbiology, Institute of Biomedical Science, University of São Paulo, São Paulo 05508-000, SP, Brazil.\nDepartment of Stomatology, School of Dentistry, University of São Paulo, São Paulo 05508-000, SP, Brazil.",
"collective": null,
"firstname": "Fernando Henrique",
"initials": "FH",
"lastname": "Martins"
},
{
"affiliation": "Department of Microbiology, Institute of Biomedical Science, University of São Paulo, São Paulo 05508-000, SP, Brazil.\nDepartment of Stomatology, School of Dentistry, University of São Paulo, São Paulo 05508-000, SP, Brazil.\nDivision of Periodontics, Faculdade São Leopoldo Mandic, São Leopoldo Mandic Research Institute, Campinas 13045-755, SP, Brazil.",
"collective": null,
"firstname": "Manuela Rocha",
"initials": "MR",
"lastname": "Bueno"
},
{
"affiliation": "Department of Microbiology, Institute of Biomedical Science, University of São Paulo, São Paulo 05508-000, SP, Brazil.",
"collective": null,
"firstname": "Karin H",
"initials": "KH",
"lastname": "Ishikawa"
},
{
"affiliation": "Department of Microbiology, Institute of Biomedical Science, University of São Paulo, São Paulo 05508-000, SP, Brazil.",
"collective": null,
"firstname": "Ellen Sayuri",
"initials": "ES",
"lastname": "Ando-Suguimoto"
},
{
"affiliation": "Department of Microbiology, Institute of Biomedical Science, University of São Paulo, São Paulo 05508-000, SP, Brazil.",
"collective": null,
"firstname": "Aline Ramos",
"initials": "AR",
"lastname": "Carlucci"
},
{
"affiliation": "Department of Prosthesis and Periodontology, School of Dentistry, University of Campinas, Campinas 13083-875, SP, Brazil.",
"collective": null,
"firstname": "Leticia Sandoli",
"initials": "LS",
"lastname": "Arroteia"
},
{
"affiliation": "Department of Prosthesis and Periodontology, School of Dentistry, University of Campinas, Campinas 13083-875, SP, Brazil.",
"collective": null,
"firstname": "Renato V",
"initials": "RV",
"lastname": "Casarin"
},
{
"affiliation": "Department of Stomatology, School of Dentistry, University of São Paulo, São Paulo 05508-000, SP, Brazil.",
"collective": null,
"firstname": "Luciana",
"initials": "L",
"lastname": "Saraiva"
},
{
"affiliation": "Department of Microbiology, Institute of Biomedical Science, University of São Paulo, São Paulo 05508-000, SP, Brazil.",
"collective": null,
"firstname": "Maria Regina Lorenzetti",
"initials": "MRL",
"lastname": "Simionato"
},
{
"affiliation": "Department of Microbiology, Institute of Biomedical Science, University of São Paulo, São Paulo 05508-000, SP, Brazil.\nDepartment of Stomatology, School of Dentistry, University of São Paulo, São Paulo 05508-000, SP, Brazil.",
"collective": null,
"firstname": "Marcia Pinto Alves",
"initials": "MPA",
"lastname": "Mayer"
}
] |
International journal of molecular sciences
| null |
39125663
29926951
25498392
29926487
26197893
23665198
31668171
10024565
20863570
32230992
2895743
2470678
21559515
35187533
29988721
35048045
33117737
17470028
22036469
24797416
26218067
29066788
11443232
11283726
32388252
29319048
30837987
24861975
35211692
23784124
17586632
24825893
27353758
15197391
15784534
17620359
29655406
33689000
36839184
18626197
27531913
23936002
15850760
17177972
16390336
20053385
23906379
31611409
30681069
25280752
30414445
33255499
16194227
28408901
22782113
35027607
24697951
19164580
24566623
11420041
12925700
18927210
18952050
17823788
17519423
27742762
17372023
22092031
35149024
23174631
18305141
35732628
32464078
28198672
28871594
34050328
32459164
20955468
30237392
30700431
31034508
19722792
32504490
27698916
29285324
33618627
10522223
28721251
34630089
24250214
20565988
32001212
11923240
26527214
28614714
21472016
31341288
23193283
24293649
26028277
33268781
32414415
|
Experimental Inoculation of
| null | null | null | null | null | null |
null |
© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
|
10.1111/phpp.12370
|
Eight patients were included. Median age was 45.5 years (range, 23-64). Light spectrum most commonly implicated was UV-A. Clinical outcomes: 89% (7/8) achieved CCR with omalizumab. Phototesting was normal in 42.8% (3/7) of them. In our review, we identified 38 patients (including the current case series), and 68.4% showed favourable outcomes with omalizumab. Median time since onset of SU was lower in responders.
|
[
"chronic inducible urticaria",
"omalizumab",
"photobiology",
"physical urticaria",
"solar urticaria",
"urticaria"
] |
2017-11-25
|
Solar urticaria (SU) is a rare photodermatosis. Treatment is challenging, and outcomes are often disappointing. Omalizumab is an anti-IgE, currently approved for treatment of chronic spontaneous urticaria. We sought to evaluate therapy with omalizumab in refractory SU and describe predictive factors for response.
Patients with refractory SU under treatment with omalizumab were included in this study. Clinical outcome was evaluated using the Urticaria Activity Score 7 (UAS7), Dermatology Life Quality Index (DLQI) and Pruritus Visual Analogue Scale (VAS). Complete clinical response (CCR) was defined as having an UAS7 = 0, DLQI <6 and VAS = 0. Phototesting was performed and compared to baseline. We performed a PubMed search to identify reported cases of SU in adults treated with omalizumab, analysing their characteristics in order to predict response to omalizumab.
Eight patients were included. Median age was 45.5 years (range, 23-64). Light spectrum most commonly implicated was UV-A. Clinical outcomes: 89% (7/8) achieved CCR with omalizumab. Phototesting was normal in 42.8% (3/7) of them. In our review, we identified 38 patients (including the current case series), and 68.4% showed favourable outcomes with omalizumab. Median time since onset of SU was lower in responders.
Omalizumab can be an effective treatment in refractory SU.
|
[
{
"affiliation": "Department of Dermatology, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Spain.",
"collective": null,
"firstname": "Daniel",
"initials": "D",
"lastname": "Morgado-Carrasco"
},
{
"affiliation": "Department of Dermatology, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Spain.",
"collective": null,
"firstname": "Xavier",
"initials": "X",
"lastname": "Fustà-Novell"
},
{
"affiliation": "Department of Dermatology, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Spain.",
"collective": null,
"firstname": "Sebastian",
"initials": "S",
"lastname": "Podlipnik"
},
{
"affiliation": "Department of Dermatology, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Spain.",
"collective": null,
"firstname": "Andrea",
"initials": "A",
"lastname": "Combalia"
},
{
"affiliation": "Department of Dermatology, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Spain.",
"collective": null,
"firstname": "Paula",
"initials": "P",
"lastname": "Aguilera"
}
] |
Photodermatology, photoimmunology & photomedicine
| null |
29171925
|
Clinical and photobiological response in eight patients with solar urticaria under treatment with omalizumab, and review of the literature.
| null | null | null | null | null | null |
null |
Copyright © 2011 Elsevier Masson SAS. All rights reserved.
|
10.1016/j.anorl.2011.05.006
|
Six female and 58 male patients were included. Forty (62.5%) had negative margins (group 1) and 24 (37.5%) positive margins (group 2). Overall five-year survival was 97% (95% in group 1 and 100% in group 2). Five-year recurrence-free survival was 94% (91.7% in group 1 and 95% in group 2). There was no significant difference in overall or recurrence-free survival according to resection margin histologic status.
|
[] |
2011-11-22
|
The small size of endoscopic laser cordectomy (ELC) specimens frequently leads the histopathologist to assess excision margins as pathologic. The present study sought to assess the prognostic value of margin status in terms of overall and of recurrence-free survival in a population of T1a glottic carcinoma operated on by ELC.
Sixty-four records of T1a squamous-cell carcinoma treated between 1996 and 2006 were retrospectively analyzed. Overall and recurrence-free survival for the group with negative margins (group 1) and with positive margins (group 2) were analyzed following Kaplan-Meier. The influence of resection margin histologic status was assessed on Log Rank test.
Six female and 58 male patients were included. Forty (62.5%) had negative margins (group 1) and 24 (37.5%) positive margins (group 2). Overall five-year survival was 97% (95% in group 1 and 100% in group 2). Five-year recurrence-free survival was 94% (91.7% in group 1 and 95% in group 2). There was no significant difference in overall or recurrence-free survival according to resection margin histologic status.
The present results show that margins considered positive after laser resection do not significantly impact carcinologic course, while still requiring close surveillance. The most generally recommended attitude is control endoscopy with biopsy at 10 weeks.
|
[
{
"affiliation": "Service ORL et chirurgie cervicofaciale, AP-HM, CHU La Timone, 264, rue St-Pierre, 13385 Marseille cedex, France. [email protected]",
"collective": null,
"firstname": "J",
"initials": "J",
"lastname": "Michel"
},
{
"affiliation": null,
"collective": null,
"firstname": "N",
"initials": "N",
"lastname": "Fakhry"
},
{
"affiliation": null,
"collective": null,
"firstname": "S",
"initials": "S",
"lastname": "Duflo"
},
{
"affiliation": null,
"collective": null,
"firstname": "A",
"initials": "A",
"lastname": "Lagier"
},
{
"affiliation": null,
"collective": null,
"firstname": "J",
"initials": "J",
"lastname": "Mancini"
},
{
"affiliation": null,
"collective": null,
"firstname": "P",
"initials": "P",
"lastname": "Dessi"
},
{
"affiliation": null,
"collective": null,
"firstname": "A",
"initials": "A",
"lastname": "Giovanni"
}
] |
European annals of otorhinolaryngology, head and neck diseases
| null |
22100362
|
Prognostic value of the status of resection margins after endoscopic laser cordectomy for T1a glottic carcinoma.
| null | null | null | null | null | null |
null |
© 2024. The Author(s).
|
10.1186/s12911-024-02725-7
| null |
[
"Accelerated hazard model",
"Breast cancer",
"Deep learning",
"Interval censoring",
"Prediction"
] |
2024-10-29
|
Breast cancer is the most common cancer in women. Previous studies have investigated estimating and predicting the proportional hazard rates and survival in breast cancer. This study deals with predicting accelerated hazards (AH) rate based on age categories in breast cancer patients using deep learning methods. The AH has a time-dependent structure whose rate changes according to time and variable effects. We have collected data related to 1225 female patients with breast cancer at the Mandarin University of Medical Sciences. The patients' demographic and clinical characteristics including family history, age, history of tobacco use, hysterectomy, first menstruation age, gravida, number of breastfeeding, disease grade, marital status, and survival status have been recorded. Initially, we dealt with predicting three age groups of patients: ≤ 40, 41-60, and ≥ 61 years. Then, the prediction of accelerated risk value based on age categories for each breast cancer patient through deep learning and the importance of variables using LightGBM is discussed. Improving clinical management and treatment of breast cancer requires advanced methods such as time-dependent AH calculation. When the behavioral effect is assumed as a time scale change between hazard functions, the AH model is more appropriate for randomized clinical trials. The study results demonstrate the proper performance of the proposed model for predicting AH by age categories based on breast cancer patients' demographic and clinical characteristics.
|
[
{
"affiliation": "Department of Epidemiology and Biostatistics, School of Health, Health Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran.",
"collective": null,
"firstname": "Zahra",
"initials": "Z",
"lastname": "Ramezani"
},
{
"affiliation": "Department of Epidemiology and Biostatistics, School of Health, Health Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran. [email protected].",
"collective": null,
"firstname": "Jamshid Yazdani",
"initials": "JY",
"lastname": "Charati"
},
{
"affiliation": "Gastrointestinal Cancer Research Center, Non-Communicable Diseases Research Institute, Mazandaran University of Medical Sciences, Sari, Iran.",
"collective": null,
"firstname": "Reza",
"initials": "R",
"lastname": "Alizadeh-Navaei"
},
{
"affiliation": "Department of Hematology and Oncology, Gastrointestinal Cancer Research Center, Mazandaran University of Medical Sciences, Sari, Iran.",
"collective": null,
"firstname": "Mohammad",
"initials": "M",
"lastname": "Eslamijouybari"
}
] |
BMC medical informatics and decision making
| null |
39468511
26540668
36624014
36653207
21457194
3814726
12407686
10783801
10783800
22169032
12375301
17094075
11550937
28004414
37860197
15894097
31161190
27822938
30733056
25889186
28608412
36012080
36653206
36805386
31221197
36426919
29676945
31881042
16106024
|
Accelerated hazard prediction based on age time-scale for women diagnosed with breast cancer using a deep learning method.
| null | null | null | null | null | null |
null |
Copyright © 2024 Elsevier Inc. All rights reserved.
|
10.1016/j.envres.2024.118322
| null |
[
"Acute coronary syndrome",
"Interaction",
"Metals",
"Nested case-control study",
"Prospective cohort",
"microRNA-4286"
] |
2024-02-16
|
Mounting evidence suggests that metal/metalloid exposure is related to the adverse health effects. Our prior investigation revealed a positive relation between the plasma level of microRNA-4286 (miR-4286) and an increased risk of developing acute coronary syndrome (ACS). However, it is a lack of studies evaluating the connection between metal/metalloid exposure and miRNA expression on ACS. In the prospective Dongfeng-Tongji cohort, we performed a nested case-control study. A total of 480 ACS and 480 controls were carefully selected based on similar age, sex, and blood collection time. Using inductively coupled plasma mass spectrometry, we assessed the plasma concentrations of 24 different metals. Quantitative real-time polymerase chain reaction was used to analyze the plasma miR-4286. We examined the relations of plasma metals with miR-4286 levels, the incidence of ACS, and the potential interactions. Using the multivariate conditional logistic regression models, we observed that the adjusted odds ratios (95% confidence intervals [CI]) for incident ACS were 1.79 (1.03, 3.12; P-trend = 0.03), 0.60 (0.41, 0.87; P-trend = 0.008), and 0.66 (0.46, 0.93; P-trend = 0.02), when comparing the extreme tertiles of aluminum, rubidium, and selenium, respectively. There was a relation between the concentration of rubidium in plasma and a decrease in the level of plasma miR-4286 (percent difference [95% CI]: -13.36% [-22.74%, -2.83%]; P-trend = 0.01). Both multiplicative (P interaction = 0.009) and additive interactions (relative excess risk due to interaction [95% CI]: 0.82 [0.59, 1.06]) were noted in our observation regarding the relationship between plasma aluminum and miR-4286 in incident ACS. The findings indicated that plasma aluminum was positively while plasma rubidium and selenium were negatively linked to an increased risk of developing ACS. Plasma aluminum exposure and plasma miR-4286 expression might synergistically affect the incident ACS risk. Controlling aluminum exposure was important for ACS prevention, especially for individuals with high expression of plasma miR-4286.
|
[
{
"affiliation": "Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Department of Disease Surveillance, Institute of Chronic Disease Control and Prevention, Hubei Provincial Center for Disease Control and Prevention, Wuhan, China.",
"collective": null,
"firstname": "Miaoyan",
"initials": "M",
"lastname": "Shen"
},
{
"affiliation": "Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.",
"collective": null,
"firstname": "Xuedan",
"initials": "X",
"lastname": "Xu"
},
{
"affiliation": "Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.",
"collective": null,
"firstname": "Wending",
"initials": "W",
"lastname": "Li"
},
{
"affiliation": "Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.",
"collective": null,
"firstname": "Xi",
"initials": "X",
"lastname": "Wang"
},
{
"affiliation": "Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.",
"collective": null,
"firstname": "Rong",
"initials": "R",
"lastname": "Peng"
},
{
"affiliation": "Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.",
"collective": null,
"firstname": "Xuezhen",
"initials": "X",
"lastname": "Liu"
},
{
"affiliation": "Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.",
"collective": null,
"firstname": "Qiuhong",
"initials": "Q",
"lastname": "Wang"
},
{
"affiliation": "Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.",
"collective": null,
"firstname": "Xiaomin",
"initials": "X",
"lastname": "You"
},
{
"affiliation": "Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.",
"collective": null,
"firstname": "Pinpin",
"initials": "P",
"lastname": "Long"
},
{
"affiliation": "Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.",
"collective": null,
"firstname": "Hao",
"initials": "H",
"lastname": "Wang"
},
{
"affiliation": "Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.",
"collective": null,
"firstname": "Rundong",
"initials": "R",
"lastname": "Niu"
},
{
"affiliation": "Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.",
"collective": null,
"firstname": "Yu",
"initials": "Y",
"lastname": "Yin"
},
{
"affiliation": "Department of Cardiovascular Diseases, Sinopharm Dongfeng General Hospital, Hubei University of Medicine, Shiyan, 442000, China.",
"collective": null,
"firstname": "Handong",
"initials": "H",
"lastname": "Yang"
},
{
"affiliation": "Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.",
"collective": null,
"firstname": "Xiaomin",
"initials": "X",
"lastname": "Zhang"
},
{
"affiliation": "Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.",
"collective": null,
"firstname": "Meian",
"initials": "M",
"lastname": "He"
},
{
"affiliation": "Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.",
"collective": null,
"firstname": "Tangchun",
"initials": "T",
"lastname": "Wu"
},
{
"affiliation": "Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: [email protected].",
"collective": null,
"firstname": "Yu",
"initials": "Y",
"lastname": "Yuan"
}
] |
Environmental research
| null |
38360166
|
Prospective findings from the Dongfeng-Tongji cohort: Exposure to various metals, the expression of microRNA-4286, and the incidence of acute coronary syndrome.
| null | null | null | null | null | null |
null |
© 2025 Institute of Food Technologists®.
|
10.1111/1541-4337.70148
| null |
[
"broiler chickens",
"mitochondria",
"muscle myopathy",
"oxidation",
"reactive oxygen species"
] |
2025-03-05
|
Wooden breast (WB) is a multifactorial muscular abnormality resulting from the interplay between genetic predispositions for rapid growth, physiological stress, and anatomical impairments. This myopathy has been a persistent challenge in the poultry industry since its initial identification a decade ago. WB negatively impacts meat quality, leading to increased toughness and reduced nutritional value. Building on foundational research utilizing multiomics technologies, hypoxia-induced oxidative stress has been identified as a key early event driving the pathological processes of WB. This review provides a comprehensive overview and the state-of-the-art evidence on the pivotal role of oxidative stress in WB myopathy. It begins by examining the generation of reactive intermediates that induce oxidative damage and the host's defense mechanisms aimed at mitigating these threats. The discussion then focuses on the consequences of oxidative damage for mitochondria, protein and lipid oxidation, connective tissue remodeling, and inflammation-pathological hallmarks of WB-affected muscles. Additionally, the review highlights how oxidative stress influences satellite cell behavior, impairing the repair and regeneration of muscle tissues, a process implicated in WB. Finally, efforts to prevent or mitigate WB myopathy are summarized, with particular attention to potential intervention strategies targeting oxidative stress. These include innovative feed formulations and gut microbiota modulation, which show promise in alleviating the severity of the condition.
|
[
{
"affiliation": "Department of Food and Nutrition Sciences, University of Helsinki, Helsinki, Finland.",
"collective": null,
"firstname": "Yaqin",
"initials": "Y",
"lastname": "Wang"
},
{
"affiliation": "Department of Food and Nutrition Sciences, University of Helsinki, Helsinki, Finland.",
"collective": null,
"firstname": "Binbin",
"initials": "B",
"lastname": "Li"
},
{
"affiliation": "Human Microbiome Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.",
"collective": null,
"firstname": "Ching",
"initials": "C",
"lastname": "Jian"
},
{
"affiliation": "PEGASE, INRAE, Institut Agro, Saint-Gilles, France.",
"collective": null,
"firstname": "Mohammed",
"initials": "M",
"lastname": "Gagaoua"
},
{
"affiliation": "TECAL Research Group, IPROCAR Research Institute, Universidad de Extremadura, Caceres, Spain.",
"collective": null,
"firstname": "Mario",
"initials": "M",
"lastname": "Estévez"
},
{
"affiliation": "Department of Food and Nutrition Sciences, University of Helsinki, Helsinki, Finland.",
"collective": null,
"firstname": "Eero",
"initials": "E",
"lastname": "Puolanne"
},
{
"affiliation": "Department of Food and Nutrition Sciences, University of Helsinki, Helsinki, Finland.",
"collective": null,
"firstname": "Per",
"initials": "P",
"lastname": "Ertbjerg"
}
] |
Comprehensive reviews in food science and food safety
| null |
40040485
|
Oxidative stress-induced changes in wooden breast and mitigation strategies: A review.
| null | null | null | null | null | null |
null | null |
10.1016/0020-7101(72)90017-7
| null |
[] |
1972-07-01
| null |
[
{
"affiliation": null,
"collective": null,
"firstname": "R B",
"initials": "RB",
"lastname": "Marshall"
},
{
"affiliation": null,
"collective": null,
"firstname": "D",
"initials": "D",
"lastname": "Reekie"
},
{
"affiliation": null,
"collective": null,
"firstname": "A",
"initials": "A",
"lastname": "Fleck"
}
] |
International journal of bio-medical computing
| null |
4557768
|
Computer-assisted diagnosis of metabolic bone disease using biochemistry test results.
| null | null | null | null | null | null |
null |
Copyright © 2019 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.
|
10.1016/j.joms.2019.05.022
|
The sample included 81 patients with MOKCs; 21 (25.6%) were male and 60 (74.07%) were female. The age range was 7 to 63 years (mean ± standard deviation, 18.4 ± 4). The overall recurrence rate was 26.63%, with an overall recurrence-free interval of 26.85 months. The average length of follow-up was 55.68 months. No association was found between the treatment method used and the risk of recurrence (P = .178). Although the interval to recurrence was not affected by any of the study variables, the average interval to the recurrence of MOKCs involving the maxilla was short compared with that of MOKCs involving the mandible.
|
[] |
2019-07-06
|
The optimal treatment of odontogenic keratocysts (OKCs) remains a matter of debate in reported studies. The present study aimed to estimate the postoperative recurrence rates of multiple OKCs (MOKCs) in Chinese patients.
A retrospective cohort study of histologically confirmed MOKCs treated from 2003 to 2017 using enucleation, marsupialization alone, enucleation and peripheral ostectomy, or marsupialization followed by secondary enucleation was performed. Patients with MOKCs who had undergone follow-up for 12 or more months with panoramic radiographs and radiographs of the chest and skull available from the first visit and had been treated by the same team using the same treatment protocol were included in the study. Patients were excluded if the lesion had been treated previously, they had a solitary OKC, or their medical records were not available for review. The treatment methods, recurrence rate, and interval to recurrence were evaluated. The Kaplan-Meier method was used to estimate the survival rate and median time to recurrence. Univariate analysis was used to identify the risk factors associated with recurrence. Significant differences were determined at an α level of 5%.
The sample included 81 patients with MOKCs; 21 (25.6%) were male and 60 (74.07%) were female. The age range was 7 to 63 years (mean ± standard deviation, 18.4 ± 4). The overall recurrence rate was 26.63%, with an overall recurrence-free interval of 26.85 months. The average length of follow-up was 55.68 months. No association was found between the treatment method used and the risk of recurrence (P = .178). Although the interval to recurrence was not affected by any of the study variables, the average interval to the recurrence of MOKCs involving the maxilla was short compared with that of MOKCs involving the mandible.
The surgical treatment method did not influence the risk of recurrence in patients with MOKCs, and the interval to recurrence was not associated with any of the study variables.
|
[
{
"affiliation": "Resident, Department of Oral Maxillofacial Head and Neck Oncology Surgery, School and Hospital of Stomatology, Wuhan University, Wuhan, China.",
"collective": null,
"firstname": "Nyimi Bushabu",
"initials": "NB",
"lastname": "Fidele"
},
{
"affiliation": "Professor, Department of Oral Maxillofacial Head and Neck Oncology Surgery; and State Key Laboratory Breeding Base of Basic Science of Stomatology and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China.",
"collective": null,
"firstname": "Yifang",
"initials": "Y",
"lastname": "Zhao"
},
{
"affiliation": "Resident, Department of Oral Maxillofacial Head and Neck Oncology Surgery, School and Hospital of Stomatology, Wuhan University, Wuhan, China.",
"collective": null,
"firstname": "Wu",
"initials": "W",
"lastname": "Tianfu"
},
{
"affiliation": "Resident, Department of Oral Maxillofacial Head and Neck Oncology Surgery, School and Hospital of Stomatology, Wuhan University, Wuhan, China.",
"collective": null,
"firstname": "Yanfang",
"initials": "Y",
"lastname": "Sun"
},
{
"affiliation": "Resident, Department of Oral Maxillofacial Head and Neck Oncology Surgery, School and Hospital of Stomatology, Wuhan University, Wuhan, China.",
"collective": null,
"firstname": "Qiwen",
"initials": "Q",
"lastname": "Man"
},
{
"affiliation": "Associate Professor, Department of Oral Maxillofacial Head and Neck Oncology Surgery; and State Key Laboratory Breeding Base of Basic Science of Stomatology and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China. Electronic address: [email protected].",
"collective": null,
"firstname": "Bing",
"initials": "B",
"lastname": "Liu"
}
] |
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
| null |
31276655
|
Treatment of Multiple Odontogenic Keratocysts Involving Chinese Patients.
| null | null | null | null | null | null |
null | null |
10.1044/2024_AJSLP-23-00332
10.1002/alz.13027
10.1177/24730114221119180
10.1001/jamanetworkopen.2023.27315
10.1212/CON.0000000000001088
10.1097/WAD.0b013e3181a6bebc
10.1001/jamanetworkopen.2022.16267
10.1519/JPT.0000000000000187
10.1001/jamainternmed.2021.4260
10.1111/jgs.18311
10.3233/JAD-2010-1316
10.5001/omj.2011.38
10.1001/jamanetworkopen.2022.10774
10.1056/NEJMp1802313
10.7326/M13-2946
10.1097/MLR.0000000000001577
10.2307/2626958
10.3389/fpubh.2020.00231
10.1056/NEJMoa0902234
10.2105/AJPH.2004.058040
10.3390/ijerph16132354
10.1161/SVIN.122.000487
10.1177/0022146510383498
10.1001/jamanetworkopen.2020.7559
10.31486/toj.23.0012
10.1080/23251042.2016.1220848
10.1007/s10900-013-9681-1
10.1038/s41582-022-00630-z
10.1007/s11606-018-4615-3
10.3233/JAD-220402
10.1158/1055-9965.EPI-05-0456
10.1093/ije/dyr236
10.1016/j.jalz.2018.02.016
10.1097/MLR.0b013e31819a5acc
10.1002/trc2.12039
|
ADI was significantly higher in this cohort (
|
[] |
2024-03-19
|
Socioeconomically disadvantaged areas are more resource poor, impacting adherence to swallowing care recommendations. Neighborhood-level disadvantage metrics, such as the Area Deprivation Index (ADI), allow for examination of social determinants of health (SDOH) in a precise region. We examined ADI in a cohort of persons living with dementia (PLWD) to determine representation of those residing in areas of socioeconomic disadvantage (high ADI), distribution of swallowing care provided, and frequency of SDOH-related counseling or resource linking prior to discharge.
A retrospective chart abstraction was performed for all inpatients with a diagnosis of dementia (
ADI was significantly higher in this cohort (
These findings raise important questions about the role and responsibility of speech-language pathologists in tailoring swallowing services to challenges posed by the lived environment, particularly in socioeconomically disadvantaged areas. This underscores the need for further research to understand and address gaps in postdischarge support for PLWD in high-ADI regions and advocate for more equitable provision of swallowing care.
|
[
{
"affiliation": "Division of Geriatrics and Gerontology, Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison.\nCenter for Health Disparities Research, University of Wisconsin-Madison.",
"collective": null,
"firstname": "Raele Donetha",
"initials": "RD",
"lastname": "Robison"
},
{
"affiliation": "Department of Integrative Biology, College of Letters and Sciences, University of Wisconsin-Madison.",
"collective": null,
"firstname": "Nicole",
"initials": "N",
"lastname": "Butz"
},
{
"affiliation": "Division of Geriatrics and Gerontology, Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison.",
"collective": null,
"firstname": "Sara",
"initials": "S",
"lastname": "Gustafson"
},
{
"affiliation": "Department of Otolaryngology, Tulane University, New Orleans, LA.",
"collective": null,
"firstname": "Steven",
"initials": "S",
"lastname": "Wang"
},
{
"affiliation": "Department of Physical Therapy and Rehabilitation Science, University of Maryland School of Medicine, Baltimore.\nDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore.",
"collective": null,
"firstname": "Jason",
"initials": "J",
"lastname": "Falvey"
},
{
"affiliation": "Division of Geriatrics and Gerontology, Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison.",
"collective": null,
"firstname": "Meredith",
"initials": "M",
"lastname": "Mackowicz-Torres"
},
{
"affiliation": "Division of Geriatrics and Gerontology, Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison.\nGeriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, WI.",
"collective": null,
"firstname": "Nicole",
"initials": "N",
"lastname": "Rogus-Pulia"
},
{
"affiliation": "Division of Geriatrics and Gerontology, Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison.\nCenter for Health Disparities Research, University of Wisconsin-Madison.",
"collective": null,
"firstname": "Amy",
"initials": "A",
"lastname": "Kind"
}
] |
American journal of speech-language pathology
|
A retrospective chart abstraction was performed for all inpatients with a diagnosis of dementia (
|
38502719
37074203
36046551
37540516
35678407
19527577
19568149
35679050
29533283
34424276
36896859
20308785
22043406
35522278
29949490
25437404
34091580
7560851
32626678
19828530
16380567
31277250
37384280
20943581
32525547
37711477
28944245
23543372
35260817
30128789
35871347
16103423
22296988
29621480
19584762
32548238
|
Ready for Discharge, but Are They Ready to Go Home? Examining Neighborhood-Level Disadvantage as a Marker of the Social Exposome and the Swallowing Care Process in a Retrospective Cohort of Inpatients With Dementia.
| null | null | null | null | null | null |
null |
Copyright © 2025 Gu, Wu and Jiang.
|
10.3389/fmed.2024.1511566
10.1038/eye.1992.63
10.1136/bjo.75.8.508
10.1038/sj.eye.6702334
10.1038/sj.eye.6702824
10.1159/000448512
10.3928/1542-8877-19930901-09
10.3928/0191-3913-19840901-06
10.1016/S0161-6420(87)80009-X
| null |
[
"cheese wire forward",
"encircling band",
"rhegmatogenous retinal detachment",
"scleral buckling surgery",
"transmuscular migration"
] |
2025-01-22
|
We present a case of transmuscular migration of a solid encircling silicone band through all four rectus muscles.
A 33-year-old male with high myopia presented with a progressively worsening subclinical peripheral rhegmatogenous retinal detachment in his left eye. An encircling silicone band (#240) was placed anterior to the equator, and 5-0 polyester sutures (Ethicon, Inc.) were used to secure the band at all four quadrants. Six months later, the encircling band and suture knots were visible under the bulb conjunctiva, close to the limbus in all four quadrants. One and a half years after the retinal detachment surgery, the encircling band was removed because of a mild foreign body sensation. During that surgery, it was noted that the encircling band was located anterior to the insertion of all four rectus muscles. Throughout the entire follow-up period, the position and movement of the left eye remained normal.
A deep and long bite of the sclera should be used to secure the silicone band, especially in cases of high myopia and when the band is placed anterior to the equator. Even if the encircling silicone band cheese wire through the four rectus muscles, ocular motility may still remain normal.
|
[
{
"affiliation": "Department of Ophthalmology and Vision Science, Eye and ENT Hospital of Fudan University, Shanghai, China.\nShanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai, China.\nNHC Key Laboratory of Myopia (Fudan University), Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China.",
"collective": null,
"firstname": "Ruiping",
"initials": "R",
"lastname": "Gu"
},
{
"affiliation": "Department of Ophthalmology and Vision Science, Eye and ENT Hospital of Fudan University, Shanghai, China.\nShanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai, China.\nNHC Key Laboratory of Myopia (Fudan University), Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China.",
"collective": null,
"firstname": "Kaicheng",
"initials": "K",
"lastname": "Wu"
},
{
"affiliation": "Department of Ophthalmology and Vision Science, Eye and ENT Hospital of Fudan University, Shanghai, China.\nShanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai, China.\nNHC Key Laboratory of Myopia (Fudan University), Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China.",
"collective": null,
"firstname": "Chunhui",
"initials": "C",
"lastname": "Jiang"
}
] |
Frontiers in medicine
| null |
39839654
|
Case report: Transmuscular migration of a solid encircling silicone band through all four rectus muscles.
| null | null | null | null | null | null |
null | null |
10.1021/acs.inorgchem.4c03165
| null |
[] |
2024-10-18
|
A rigid nicotinate-modified lanthanide-substituted selenotungstate [H
|
[
{
"affiliation": "Henan Key Laboratory of Polyoxometalate Chemistry, College of Chemistry and Molecular Sciences, Henan University, Kaifeng, Henan 475004, China.",
"collective": null,
"firstname": "Lulu",
"initials": "L",
"lastname": "Liu"
},
{
"affiliation": "Henan Key Laboratory of Polyoxometalate Chemistry, College of Chemistry and Molecular Sciences, Henan University, Kaifeng, Henan 475004, China.",
"collective": null,
"firstname": "Limin",
"initials": "L",
"lastname": "Cui"
},
{
"affiliation": "Henan Key Laboratory of Polyoxometalate Chemistry, College of Chemistry and Molecular Sciences, Henan University, Kaifeng, Henan 475004, China.",
"collective": null,
"firstname": "Jun",
"initials": "J",
"lastname": "Jiang"
},
{
"affiliation": "Henan Key Laboratory of Polyoxometalate Chemistry, College of Chemistry and Molecular Sciences, Henan University, Kaifeng, Henan 475004, China.",
"collective": null,
"firstname": "Lijuan",
"initials": "L",
"lastname": "Chen"
},
{
"affiliation": "Henan Key Laboratory of Polyoxometalate Chemistry, College of Chemistry and Molecular Sciences, Henan University, Kaifeng, Henan 475004, China.",
"collective": null,
"firstname": "Junwei",
"initials": "J",
"lastname": "Zhao"
}
] |
Inorganic chemistry
| null |
39423351
|
Nicotinate-Modified Lanthanide-Substituted Selenotungstate and Its Catalase-like Activity for the Detection of H
| null | null | null | null | null | null |
null |
© 2024. The Author(s).
|
10.1038/s41598-023-50619-x
10.3390/lubricants9020015
10.1002/adma.202005513
10.1016/j.clinbiomech.2019.10.016
10.1243/135065005X33982
10.1016/S0021-9290(03)00291-4
10.1177/1947603520973240
10.1007/s40544-020-0468-y
10.1016/S0140-6736(01)37157-X
10.1243/JMES_JOUR_1970_012_060_02
10.1243/EMED\_JOUR\_1983\_012\_008_02
10.1243/EMED\_JOUR\_1984\_013\_035\_02
10.1243/EMED\_JOUR\_1986\_015\_019\_02
10.1115/1.3168343
10.1038/s41598-019-50091-6
10.4236/ajcm.2022.121002
10.1073/pnas.1101002108
10.1016/j.jmbbm.2019.04.008
10.1002/jmor.10748
10.1098/rspb.2012.0190
10.1111/j.1096-3642.2004.00129.x
10.1017/pab.2015.55
10.1017/S1755691018000749
10.1038/s41586-020-2974-5
10.1111/joa.13389
10.1007/s10914-021-09576-3
10.1292/jvms1939.36.121
10.1242/jeb.76.1.105
10.1242/jeb.010678
10.1093/bioinformatics/bty633
10.1111/j.2041-210X.2011.00169.x
10.1152/ajpregu.1994.266.3.r1022
10.1111/j.1469-7998.1981.tb04600.x
10.1242/jeb.138.1.301
10.3389/fphys.2017.00303
10.1007/s10237-019-01277-4
10.1016/j.apm.2017.04.013
10.1006/jtbi.1999.1025
10.1007/s11249-021-01411-3
10.1519/JSC.0b013e3181b94a7b
10.1038/srep08103
10.1146/annurev.anthro.18.1.17
10.1016/j.jse.2013.11.026
10.1088/1748-3190/abeb57
10.1242/jeb.201.23.3197
10.1242/jeb.044180
10.1098/rsos.210836
10.1016/j.mri.2012.05.001
10.7717/peerj.1417
10.1002/(SICI)1097-4687(199902)239:2
10.1371/journal.pone.0078392
10.1038/s42003-022-03748-4
10.1073/pnas.1519459113
10.1371/journal.pbio.3000494
10.1038/44766
10.1111/j.2041-210X.2010.00044.x
10.1017/S1464793106007007
10.1111/j.2041-210X.2011.00153.x
| null |
[] |
2024-01-26
|
Synovial joints, such as the elbow, experience different lubrication regimes, ranging from fluid film to boundary lubrication, depending on locomotion conditions. We explore the relationship between the elbow lubrication regime and the size of quadrupedal mammals. We use allometry to analyze the dimensions, contact stress, and sliding speed of the elbow in 110 quadrupedal mammals. Our results reveal that the average diameter and width of the distal humerus are scaled [Formula: see text], which allowed us to estimate a consistent contact pressure and sliding speed across mammals. This consistency likely promotes fluid film lubrication regardless of body mass. Further, the ratio between the diameter and width is about 0.5 for all analyzed taxa, which is a good compromise between loading capacity and size. Our study deepens our understanding of synovial joints and their adaptations, with implications for the development of treatments, prostheses, and bioinspired joint designs.
|
[
{
"affiliation": "Aix Marseille Univ, CNRS, ISM, Marseille, France. [email protected].",
"collective": null,
"firstname": "Kalenia",
"initials": "K",
"lastname": "Marquez-Florez"
},
{
"affiliation": "Aix Marseille Univ, CNRS, ISM, Marseille, France.",
"collective": null,
"firstname": "Santiago",
"initials": "S",
"lastname": "Arroyave-Tobon"
},
{
"affiliation": "Aix Marseille Univ, CNRS, ISM, Marseille, France.",
"collective": null,
"firstname": "Loïc",
"initials": "L",
"lastname": "Tadrist"
},
{
"affiliation": "Aix Marseille Univ, CNRS, ISM, Marseille, France.",
"collective": null,
"firstname": "Jean-Marc",
"initials": "JM",
"lastname": "Linares"
}
] |
Scientific reports
| null |
38272957
|
Elbow dimensions in quadrupedal mammals driven by lubrication regime.
| null | null | null | null | null | null |
To the best of our knowledge, this is the first case of acral malignant acrospiroma with reported next generation sequencing results.
| null |
10.1186/s12885-017-3217-5
10.1001/archderm.1983.01650260012008
10.1111/cup.12720
10.1038/modpathol.3800511
10.1111/j.1524-4725.1998.tb04273.x
10.1053/ejso.2000.1067
10.7547/87507315-85-2-116
10.1111/j.1365-4632.2012.05831.x
10.2106/00004623-198264050-00022
10.1111/j.1365-4362.1995.tb01595.x
10.1016/S0363-5023(89)80018-8
10.1016/j.amjsurg.2010.04.015
10.4103/0019-5154.110849
10.7547/1020247
10.1097/DAD.0b013e3181cd64f2
10.1002/1097-0142(195409)7:5<934::AID-CNCR2820070519>3.0.CO;2-5
10.1097/00000658-197102000-00014
10.1001/archderm.1963.01590150039007
10.1097/00006534-198708000-00027
10.1001/archdermatol.2011.210
10.1111/j.1468-3083.2009.03301.x
10.1002/1097-0142(19900415)65:8<1737::AID-CNCR2820650813>3.0.CO;2-Q
10.1002/gcc.20168
10.1097/DAD.0b013e3181984f10
10.1016/j.anndiagpath.2015.08.002
| null |
[
"Acral",
"Acrospiroma",
"Case report",
"Malignant",
"Next generation"
] |
2017-03-30
|
Malignant acrospiroma is a rare tumor of the eccrine sweat glands accounting for around 6% of all malignant eccrine tumors. Typically, it presents as large ulcerated nodules, and diagnosis can be challenging as it has great overlap with its benign counterpart.
We herein report a case of acral malignant acrospiroma, initially treated with surgical excision and adjuvant radiotherapy. After metastatic disease was confirmed, subject received multiple lines of chemo- as well as targeted therapy. Genomic testing was also done using next generation sequencing.
To the best of our knowledge, this is the first case of acral malignant acrospiroma with reported next generation sequencing results.
|
[
{
"affiliation": "Department of Internal Medicine, Wayne State University, School of Medicine, Detroit, MI, USA. [email protected].",
"collective": null,
"firstname": "Maria",
"initials": "M",
"lastname": "Diab"
},
{
"affiliation": "Department of Pathology, Wayne State University, School of Medicine, Detroit, MI, USA.",
"collective": null,
"firstname": "Ali",
"initials": "A",
"lastname": "Gabali"
},
{
"affiliation": "Cardinal Bernardin Cancer Center, Loyola University Chicago Stritch School of Medicine, Maywood, IL, USA.",
"collective": null,
"firstname": "Muaiad",
"initials": "M",
"lastname": "Kittaneh"
}
] |
BMC cancer
| null |
28347286
6297408
27080562
16446719
9723060
11417993
7877107
2823361
23968240
6282887
7790144
2544641
20851376
23723491
22659768
20534988
15606845
13199772
5100098
14032110
3037576
21844475
19522717
2156600
15729701
19384064
26386519
|
Malignant acrospiroma: a case report in the era of next generation sequencing.
| null | null | null | null | null | null |
High stunting, increasing trends of overweight/ obesity, anaemia, serum vitamin D insufficiency, inadequate energy and micronutrient intake in children highlighted the triple burden of malnutrition in Java and Sumatera, Indonesia's most populous regions in 2019-2020, shortly before COVID-19 pandemic era.
| null |
10.1017/S1368980024001654
| null |
[
"Child growth",
"Dietary intakes",
"Indonesian children",
"Micronutrient deficiencies",
"Nutritional status"
] |
2025-01-07
|
The South East Asian Nutrition Survey II Indonesia aimed to provide up-to-date data on dietary intake, nutritional and biochemical status of children aged 0·5-12 years in Indonesia 2019-2020.
Multistage cluster sampling, stratified by geographical location.
Out of forty-six targeted districts in Indonesia, the study only covered twenty-one districts/cities in Java and Sumatera islands, Indonesia due to COVID-19 pandemic.
A total of 2475 children aged 0·5-12 years were included.
The growth (weight-for-age, height-for-age, weight-for-height and BMI-for-age) of Indonesian pre-school- and school-aged children was below the WHO standards. The prevalence of stunting in Java and Sumatera islands was 20·6 and 33·4 % in urban and rural areas, respectively. Stunting was higher in the 1·0-3·9-year age group, boys and rural areas. Overall, 9-12 percent of all children were overweight -obese, with 23·7 % of urban 7-12-year-olds having the highest prevalence.Anaemia was 22·8 % in < 5-year-old and highest in < 1-year-old children. Fe, Zn, vitamins A and D insufficiency was observed in 20·3 %, 11·9 %, 1·9 % and 27·1 % of the children. Dietary intakes of energy, fibre, Ca, Fe, Zn, vitamins A, B1, C and vitamin D below the Indonesian RDA were prevalent and observed in more than half of the children.
High stunting, increasing trends of overweight/ obesity, anaemia, serum vitamin D insufficiency, inadequate energy and micronutrient intake in children highlighted the triple burden of malnutrition in Java and Sumatera, Indonesia's most populous regions in 2019-2020, shortly before COVID-19 pandemic era.
|
[
{
"affiliation": "SEANUTS Indonesian Team/Faculty of Medicine, Universitas Indonesia, Depok, Indonesia.\nCommunity Medicine Department, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia.",
"collective": null,
"firstname": "Aria",
"initials": "A",
"lastname": "Kekalih"
},
{
"affiliation": "SEANUTS Indonesian Team/Faculty of Medicine, Universitas Indonesia, Depok, Indonesia.\nDepartment of Nutrition, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia.",
"collective": null,
"firstname": "Dian Novita",
"initials": "DN",
"lastname": "Chandra"
},
{
"affiliation": "SEANUTS Indonesian Team/Faculty of Medicine, Universitas Indonesia, Depok, Indonesia.\nCommunity Medicine Department, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia.",
"collective": null,
"firstname": "Listya Tresnanti",
"initials": "LT",
"lastname": "Mirtha"
},
{
"affiliation": "FrieslandCampina, Stationsplein 4, Amersfoort, The Netherlands.",
"collective": null,
"firstname": "Ilse",
"initials": "I",
"lastname": "Khouw"
},
{
"affiliation": "FrieslandCampina, Stationsplein 4, Amersfoort, The Netherlands.",
"collective": null,
"firstname": "Gerard",
"initials": "G",
"lastname": "Wong"
},
{
"affiliation": "SEANUTS Indonesian Team/Faculty of Medicine, Universitas Indonesia, Depok, Indonesia.\nDepartment of Child Health, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia.",
"collective": null,
"firstname": "Rini",
"initials": "R",
"lastname": "Sekartini"
},
{
"affiliation": null,
"collective": null,
"firstname": null,
"initials": null,
"lastname": null
}
] |
Public health nutrition
| null |
39763281
|
Dietary intakes, nutritional and biochemical status of 6 months to 12-year-old children before the COVID-19 pandemic era: the South East Asian Nutrition Survey II Indonesia (SEANUTS II) study in Java and Sumatera Islands, Indonesia.
| null | null | null | null | null | null |
null | null |
10.1109/TBME.2024.3510275
| null |
[] |
2025-03-03
|
We explore the potential of deep convolutional neural network (CNN) models for differential diagnosis of gout from musculoskeletal ultrasound (MSKUS). Our exhaustive study of state-of-the-art (SOTA) CNN image classification models for this problem reveals that they often fail to learn the gouty MSKUS features, including the double contour sign, tophus, and snowstorm, which are essential for sonographers' decisions. In this study, we establish a human-centered adjusting framework to make CNN models diagnosis gout in the way of thinking like sonographers. This framework consists of three components: (1) Where to adjust: Modeling sonographers' attention map to emphasize the region that needs adjust; (2) What to adjust: Identifying MSKUS instances that mislead the model to predict according to unreasonable/biased features; (3) How to adjust: Developing a human-centered training fine-tuning mechanism that adjusts CNN models to focus on the desired MSKUS feature regions. This mechanism balances the gout prediction accuracy and attention reasonability by introducing the sonographers-like attention constraints. The experimental results on clinical MSKUS datasets demonstrate that our framework significantly outperforms the existing SOTA CNN models.
|
[
{
"affiliation": null,
"collective": null,
"firstname": "Lingyu",
"initials": "L",
"lastname": "Chen"
},
{
"affiliation": null,
"collective": null,
"firstname": "Zhi",
"initials": "Z",
"lastname": "Cao"
},
{
"affiliation": null,
"collective": null,
"firstname": "Weijing",
"initials": "W",
"lastname": "Zhang"
},
{
"affiliation": null,
"collective": null,
"firstname": "Xin",
"initials": "X",
"lastname": "Tang"
},
{
"affiliation": null,
"collective": null,
"firstname": "Di",
"initials": "D",
"lastname": "Zhao"
},
{
"affiliation": null,
"collective": null,
"firstname": "Daoqiang",
"initials": "D",
"lastname": "Zhang"
},
{
"affiliation": null,
"collective": null,
"firstname": "Hongen",
"initials": "H",
"lastname": "Liao"
},
{
"affiliation": null,
"collective": null,
"firstname": "Fang",
"initials": "F",
"lastname": "Chen"
}
] |
IEEE transactions on bio-medical engineering
| null |
40030543
|
Thinking Like Sonographers: Human-Centered CNN Models for Gout Diagnosis From Musculoskeletal Ultrasound.
| null | null | null | null | null | null |
null |
Copyright © 2022 Elsevier Inc. All rights reserved.
|
10.1016/j.ypmed.2022.107040
| null |
[
"Dollar stores",
"Obesity",
"Obesogenic environment",
"Rural",
"Weight loss"
] |
2022-04-11
|
The unique obesogenic environment may influence the ability to effectively maintain weight loss in rural areas. The aim of this study was to examine the contextual relationship of neighborhood disadvantage, distance to supermarkets and supercenters, and fast food, dollar store, and exercise facility environments on weight loss following a weight-loss intervention in the United States. This analysis (n = 1177) linked weight loss outcomes from a rural, primary care-based randomized controlled trial to contextual data collected from residential addresses. Outcomes include 6-month and 24-month percent weight loss. These outcomes were compared across contextual variables, including tract level disadvantage, food accessibility, and food/exercise availability. Covariates were included in ordinary least squares (OLS) multivariable regression models for 6-month and 24-month weight loss measures, across three weight loss interventions. Contextual variables were not significantly related to percent weight loss overall across treatment arms. Participants living in a 5-mile buffer to dollar stores experienced approximately a 2% (p < 0.05) lower weight loss, but only in the least effective counseling arm (individual clinic visits), while controlling for both individual and contextual factors. Our results suggest that specific contextual variables in rural populations may play an important role in moderating weight loss outcomes especially under the conditions of less effective interventions.
|
[
{
"affiliation": "Department of Sociology, University of Kansas, USA; Department of Population Health, University of Kansas Medical Center, USA. Electronic address: [email protected].",
"collective": null,
"firstname": "Jarron M",
"initials": "JM",
"lastname": "Saint Onge"
},
{
"affiliation": "School of Medicine, Kansas City University, USA.",
"collective": null,
"firstname": "Mitchell",
"initials": "M",
"lastname": "Fagan"
},
{
"affiliation": "Department of Population Health, University of Kansas Medical Center, USA.",
"collective": null,
"firstname": "Christie A",
"initials": "CA",
"lastname": "Befort"
}
] |
Preventive medicine
| null |
35398370
|
The association between the obesogenic environment and 6-month and 24-month weight change in a rural weight loss intervention trial in the United States.
| null | null | null | null | null | null |
null | null |
10.1097/scs.0b013e3180de62a1
| null |
[] |
2007-10-04
|
Various methods have been attempted for the treatment and management of keloids; however, there is little satisfactory clinical evidence in long-term follow ups. Also, there is a preference for occurrence and recurrence in anatomic location. Usually anatomic locations with higher regional tension and more sebaceous glands are inclined toward pathogenesis. Thirty-eight keloids treated with combined surgical excision and postoperative irradiation, using electron beams with only a 10-mm opening by lead shielding, were investigated at a mean follow up of 4.4 +/- 2.5 years (range, 1-9 years) at a single institute. Ten locations such as the ear (n = 6), neck (n = 3), and upper lip (n = 1) were among the craniofacial locations. The hardness of the keloids and posttreatment scars was clinically and objectively tested with the Vancouver scar scale and a durometer, which is often used for the industrial measurement of thread balls and rubber. At a mean of 4.4 +/- 2.5 years of follow up, the clinical characteristics of the scars were significantly better posttreatment as 2.6 +/- 0.5 versus 1.0 +/- 0.6, 3.7 +/- 0.7 versus 1.7 +/- 0.7, 2.9 +/- 0.4 versus 1.3 +/- 0.5, and 2.7 +/- 0.5 versus 1.3 +/- 0.5 (keloid scars versus posttreatment scars: pigmentation, pliability, height and vascularity, respectively, P < 0.01). The durometer readings were significantly lower posttreatment, 15.2 +/- 3.9 versus 7.7 +/- 2.9 (keloid scars versus posttreatment scars, P < 0.01). The recurrence rate was 21.2% overall with none in craniofacial locations. Therefore, the combined treatment of surgical excision and postoperative electron beam irradiation is effective for scar quality and reducing the recurrence rate in long-term follow up.
|
[
{
"affiliation": "Division of Plastic and Reconstructive Surgery, Department of Developmental and Reconstructive Medicine, Nagasaki University, Graduate School of Biomedical and Sciences, Nagasaki, Japan. [email protected]",
"collective": null,
"firstname": "Sadanori",
"initials": "S",
"lastname": "Akita"
},
{
"affiliation": null,
"collective": null,
"firstname": "Kozo",
"initials": "K",
"lastname": "Akino"
},
{
"affiliation": null,
"collective": null,
"firstname": "Aya",
"initials": "A",
"lastname": "Yakabe"
},
{
"affiliation": null,
"collective": null,
"firstname": "Toshifumi",
"initials": "T",
"lastname": "Imaizumi"
},
{
"affiliation": null,
"collective": null,
"firstname": "Katsumi",
"initials": "K",
"lastname": "Tanaka"
},
{
"affiliation": null,
"collective": null,
"firstname": "Kuniaki",
"initials": "K",
"lastname": "Anraku"
},
{
"affiliation": null,
"collective": null,
"firstname": "Hiroki",
"initials": "H",
"lastname": "Yano"
},
{
"affiliation": null,
"collective": null,
"firstname": "Akiyoshi",
"initials": "A",
"lastname": "Hirano"
}
] |
The Journal of craniofacial surgery
| null |
17912105
|
Combined surgical excision and radiation therapy for keloid treatment.
| null | null | null | null | null | null |
null |
© BMJ Publishing Group Limited 2023. No commercial re-use. See rights and permissions. Published by BMJ.
|
10.1136/bcr-2023-254701
10.1097/MD.0000000000000047
10.1136/bmj.3.5559.208
10.4065/71.3.253
10.7326/0003-4819-109-4-295
10.1016/j.gore.2020.100575
10.1111/j.1365-2133.1995.tb08645.x
10.1093/annonc/mdz062
10.1056/NEJMoa1708618
10.1159/000017912
10.1111/jog.14609
10.1097/MD.0000000000025659
10.1024/0301-1526/a000661
10.1016/j.aller.2009.06.006
10.1159/000018235
| null |
[
"Connective tissue disease",
"Gynecological cancer",
"Vasculitis"
] |
2023-12-08
|
A woman in her 50s presented with acute pain and discolouration in the fingertips of both hands, without other features of connective tissue disease. The history was otherwise significant for abdominal bloating, altered bowel habit, urinary urgency and fatigue. Inflammatory markers, antinuclear antibodies, serum protein electrophoresis and complement levels were all normal. The tumour marker CA125 was significantly elevated, prompting a CT abdomen and pelvis, which revealed a large right-sided adnexal mass with multiple enhancing peritoneal and omental nodules and moderate ascites, suggestive of disseminated primary ovarian cancer.Digital ischaemia (DI) can be associated with cancer in up to 15% of cases. An underlying cancer should be suspected in patients presenting with new or worsening symptoms of DI. Prompt treatment with anticancer therapies can achieve complete resolution of DI.
|
[
{
"affiliation": "Rheumatology, Norfolk and Norwich University Hospital, Norwich, UK [email protected].\nRheumatology, Mater Misericordiae University Hospital, Dublin, Ireland.",
"collective": null,
"firstname": "Jonathan Harry",
"initials": "JH",
"lastname": "Miller"
},
{
"affiliation": "Rheumatology, Norfolk and Norwich University Hospital, Norwich, UK.",
"collective": null,
"firstname": "Peter",
"initials": "P",
"lastname": "Merry"
}
] |
BMJ case reports
| null |
38061859
25170929
6028467
8594283
3293493
32548231
7756131
31046081
29342393
9621147
9136163
33325078
34011027
28895508
19836875
28099969
7562782
10559594
|
Digital ischaemia as a presenting feature in metastatic ovarian cancer.
| null | null | null | null | null | null |
null |
© 2025 The Author(s). Advanced Science published by Wiley‐VCH GmbH.
|
10.1002/advs.202503134
| null |
[
"Supramolecular assembly",
"carbonic anhydrase IX",
"lysosome‐targeting chimeras",
"peptide amphiphile",
"targeted protein degradation"
] |
2025-04-03
|
Recently, targeted protein degradation (TPD) strategies have emerged as a promising solution to tackle undruggable proteins. While most TPD strategies target intracellular proteins, limited options exist for targeting extracellular or membrane proteins. Herein, cancer specific carbonic anhydrase IX (CAIX)-targeting supramolecular nanofibrous lysosome-targeting chimeras (Supra-LYTAC) is reported. Two self-assembling amphiphilic peptides are synthesized: one that interacts with the protein of interest (POI), and another that mediates lysosomal endocytosis by targeting a cancer-specific enzyme. Notably, these two peptides co-assemble into nanofibers capable of targeting cancer cells in a spatiotemporal manner. Through dynamic and multivalent binding, a ternary complex form (supramolecular chimeric nanostructure; CAIX-nanofiber-POI), which undergoes internalization into lysosomes where the POI is degraded through lysosomal catalytic activity. This study demonstrates the potential of supramolecular approaches to expand the scope of LYTAC technology, offering new opportunities for designing TPD strategies in the future.
|
[
{
"affiliation": "Chemistry Department, Ulsan National Institute of Science and Technology (UNIST), 50, UNIST-gil, Eonyang-eup, Ulju-gun, Ulsan, 44919, Republic of Korea.",
"collective": null,
"firstname": "Dohyun",
"initials": "D",
"lastname": "Kim"
},
{
"affiliation": "Chemistry Department, Ulsan National Institute of Science and Technology (UNIST), 50, UNIST-gil, Eonyang-eup, Ulju-gun, Ulsan, 44919, Republic of Korea.",
"collective": null,
"firstname": "Gyeongseok",
"initials": "G",
"lastname": "Yang"
},
{
"affiliation": "Chemistry Department, Ulsan National Institute of Science and Technology (UNIST), 50, UNIST-gil, Eonyang-eup, Ulju-gun, Ulsan, 44919, Republic of Korea.",
"collective": null,
"firstname": "Chaelyeong",
"initials": "C",
"lastname": "Lim"
},
{
"affiliation": "Chemistry Department, Ulsan National Institute of Science and Technology (UNIST), 50, UNIST-gil, Eonyang-eup, Ulju-gun, Ulsan, 44919, Republic of Korea.",
"collective": null,
"firstname": "Gaeun",
"initials": "G",
"lastname": "Park"
},
{
"affiliation": "Chemistry Department, Ulsan National Institute of Science and Technology (UNIST), 50, UNIST-gil, Eonyang-eup, Ulju-gun, Ulsan, 44919, Republic of Korea.",
"collective": null,
"firstname": "Jaemo",
"initials": "J",
"lastname": "Lee"
},
{
"affiliation": "Chemistry Department, Ulsan National Institute of Science and Technology (UNIST), 50, UNIST-gil, Eonyang-eup, Ulju-gun, Ulsan, 44919, Republic of Korea.",
"collective": null,
"firstname": "Youjung",
"initials": "Y",
"lastname": "Sim"
},
{
"affiliation": "Chemistry Department, Ulsan National Institute of Science and Technology (UNIST), 50, UNIST-gil, Eonyang-eup, Ulju-gun, Ulsan, 44919, Republic of Korea.",
"collective": null,
"firstname": "Ja-Hyoung",
"initials": "JH",
"lastname": "Ryu"
}
] |
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
| null |
40178177
|
Cancer Specific CAIX-Targeting Supramolecular Lysosome-Targeting Chimeras (Supra-LYTAC) for Targeted Protein Degradation.
| null | null | null | null | null | null |
This adjuvant does not impact immune competence of non-human primates and mice, and repeated administration of the adjuvant does not show renal or hepatic toxicity. Formulation of monoclonal antibodies with the immunoregulatory adjuvant, OPLS, was found to be safe and effective at mitigating immunogenicity.
|
Copyright © 2024 Jarvi, Patel, Shetty, Nguyen, Grasperge, Mager, Straubinger and Balu-Iyer.
|
10.3389/fimmu.2024.1496169
10.1016/j.xphs.2018.01.007
10.1007/s40259-020-00465-4
10.1177/0091270012436560
10.1038/gim.2012.110
10.1038/gim.2011.4
10.1055/s-0038-1649664
10.1002/1529-0131(199809)41:9<1552::AID-ART5>3.0.CO;2-W
10.1080/08820139.2020.1738456
10.1016/j.xphs.2018.03.027
10.1074/jbc.C112.396325
10.1038/s41598-021-97333-0
10.1016/j.xphs.2016.06.018
10.1016/j.ijpharm.2018.07.018
10.1038/mi.2012.100
10.4049/jimmunol.1001360
10.1038/nature06307
10.1016/j.immuni.2007.11.011
10.1016/j.ejps.2014.10.010
10.1208/aapsj0902028
10.1074/jbc.M500163200
10.1002/jps.24173
10.3389/fimmu.2021.638444
10.1080/10717544.2018.1551442
10.1038/bjc.2013.371
10.1016/j.jtho.2024.05.005
10.1002/cpt.v115.3
10.1212/WNL.0000000000205244
10.1212/WNL.0000000000206401
10.1208/s12248-015-9782-0
10.1007/s40259-018-0260-y
10.1016/0272-0590(84)90198-2
10.1007/s40259-014-0103-4
10.1007/s11095-014-1416-1
10.1016/S0021-9258(18)70226-3
10.1016/S0022-1759(98)00170-7
10.1007/978-1-61779-012-6_16
10.1007/978-1-60761-401-2_11
10.1080/15476910500362838
10.1093/ajcp/106.4.549
10.1002/0471142735.2015.108.issue-1
10.1038/s41577-019-0244-2
10.1371/journal.pone.0132479
10.1038/nm.3179
10.1016/j.imlet.2003.11.004
10.4049/jimmunol.1101398
10.1182/asheducation-2005.1.462
10.1080/17425247.2021.1981286
10.1517/17425247.4.4.427
10.1021/bi00088a009
10.1002/(SICI)1520-6017(200003)89:3<297::AID-JPS2>3.0.CO;2-P
10.3389/fimmu.2019.00965
10.1016/j.coi.2015.01.017
10.4049/jimmunol.180.1.361
10.1016/j.ymgme.2012.01.019
10.1016/j.molcel.2020.02.013
10.14348/molcells.2022.2056
10.1128/MCB.25.21.9543-9553.2005
10.1182/blood-2008-02-138073
10.1016/j.ijpharm.2015.05.069
|
Formulations of adalimumab, trastuzumab or rituximab with OPLS showed reduction in relative immunogenicity in mice compared to vehicle formulations, indicated by reduced anti-drug antibody development and significant reductions in CD138+ plasma cell differentiation in bone marrow. Titer development toward recombinant human hyaluronidase, a dispersion enhancer that was co-formulated with monoclonal antibodies, was similarly reduced. Subcutaneous administration of adalimumab with OPLS resulted in a two-fold increase in expression of type 1 regulatory (Tr1) T cell subset in the spleen. This is consistent with in vitro studies where co-culturing of dendritic cells primed with ovalbumin in the presence and absence of OPLS and antigen specific T-cells induced expression of Tr1 phenotype on live CD4+ T cells.
|
[
"anti-drug antibodies",
"formulation",
"immune tolerance",
"immunogenicity",
"protein therapeutics",
"subcutaneous administration"
] |
2024-12-25
|
Immunogenicity continues to be a challenge for development and clinical utility of monoclonal antibodies, and there are gaps in our current ability to prevent anti-drug antibody development in a safe and antigen-specific manner.
To mitigate immunogenicity of monoclonal antibodies administered subcutaneously, O-phospho-L-serine (OPLS)-the head group of the tolerance-inducing phospholipid, phosphatidylserine-was investigated as an immunoregulatory adjuvant.
Formulations of adalimumab, trastuzumab or rituximab with OPLS showed reduction in relative immunogenicity in mice compared to vehicle formulations, indicated by reduced anti-drug antibody development and significant reductions in CD138+ plasma cell differentiation in bone marrow. Titer development toward recombinant human hyaluronidase, a dispersion enhancer that was co-formulated with monoclonal antibodies, was similarly reduced. Subcutaneous administration of adalimumab with OPLS resulted in a two-fold increase in expression of type 1 regulatory (Tr1) T cell subset in the spleen. This is consistent with in vitro studies where co-culturing of dendritic cells primed with ovalbumin in the presence and absence of OPLS and antigen specific T-cells induced expression of Tr1 phenotype on live CD4+ T cells.
This adjuvant does not impact immune competence of non-human primates and mice, and repeated administration of the adjuvant does not show renal or hepatic toxicity. Formulation of monoclonal antibodies with the immunoregulatory adjuvant, OPLS, was found to be safe and effective at mitigating immunogenicity.
|
[
{
"affiliation": "Department of Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States.",
"collective": null,
"firstname": "Nicole L",
"initials": "NL",
"lastname": "Jarvi"
},
{
"affiliation": "Department of Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States.",
"collective": null,
"firstname": "Manali",
"initials": "M",
"lastname": "Patel"
},
{
"affiliation": "Department of Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States.",
"collective": null,
"firstname": "Krithika A",
"initials": "KA",
"lastname": "Shetty"
},
{
"affiliation": "Truvai Biosciences, LLC, Buffalo, NY, United States.",
"collective": null,
"firstname": "Nhan H",
"initials": "NH",
"lastname": "Nguyen"
},
{
"affiliation": "Division of Veterinary Medicine, Tulane National Primate Research Center, Covington, LA, United States.",
"collective": null,
"firstname": "Brooke F",
"initials": "BF",
"lastname": "Grasperge"
},
{
"affiliation": "Department of Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States.\nEnhanced Pharmacodynamics, LLC, Buffalo, NY, United States.",
"collective": null,
"firstname": "Donald E",
"initials": "DE",
"lastname": "Mager"
},
{
"affiliation": "Department of Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States.",
"collective": null,
"firstname": "Robert M",
"initials": "RM",
"lastname": "Straubinger"
},
{
"affiliation": "Department of Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States.",
"collective": null,
"firstname": "Sathy V",
"initials": "SV",
"lastname": "Balu-Iyer"
}
] |
Frontiers in immunology
| null |
39720710
29336981
33523413
23436264
23060045
22237443
8128430
9751087
32204629
29649469
23649621
34497305
27488899
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23149665
21037090
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18082433
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8373765
10707011
31130955
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18097037
22365055
32142689
35950451
16227604
18660382
26027488
|
Immune regulatory adjuvant approach to mitigate subcutaneous immunogenicity of monoclonal antibodies.
| null | null | null | null | null | null |
null |
Copyright © 2020, Gomez et al.
|
10.7759/cureus.9469
| null |
[
"cinpt",
"comorbid wounds",
"growth factor concentrates",
"infusion pumps",
"negative pressure therapy",
"positive pressure infusion",
"wound complications",
"wound infection"
] |
2020-09-03
|
The principle of negative pressure technique dates back to the earliest civilizations; during the Roman era, the technique of using dome-shaped cupping glasses was used to create the suction needed to promote healing. This technique was used throughout the 19th century. In 1821, a British physician named Dr. Francis Fox invented the "glass leech" technique. Thereafter in 1952, an innovative approach was introduced to the treatment of serious, complex wounds through the use of sub-atmospheric or negative pressure known as "negative pressure wound therapy" (NPWT). Later, the "vacuum-assisted closure", or VAC therapy system founded by Dr. Louis Argenta in 1990 revolutionized the advanced wound care market, and still remains the most clinically proven alternative for the treatment of complex, hard-to-heal wounds. These therapies utilize a foam dressing that is conformed to the wound bed. When sealed and placed under negative (vacuum) pressure, the system creates a unique wound-healing environment that has been shown to promote the wound-healing process, reduce edema, prepare the wound bed for closure, promote the formation of granulation tissue and remove infectious materials. The negative pressure therapy system addresses patient quality of life through an easy-to-use system designed to assist surgeons in the management and treatment of comorbid wounds, and open abdomen and other wound complications to help achieve primary fascial closure. Comorbidities can be defined as a concurrence of multiple chronic diseases in the same patient. Closed-incision negative pressure therapy (CINPT) has revolutionized the way in which caregivers treat the most serious, complex wounds or comorbid wounds. Wound healing can be achieved by the host's innate and adaptive immune defence mechanisms as in an uninfected simple surgical incision through the skin or by combination of the host's defence mechanisms and therapeutic modalities. It has been confirmed in some clinical researches that growth factors exert amazing effects on wound-healing promotion and skin function restoration without any obvious side effects. In this review, we have hypothesized a novel modality, focusing on the treatment of wound complications secondary to comorbidity by a combination of negative pressure therapy followed by a positive pressure infusion with growth factor concentrates.
|
[
{
"affiliation": "Conservative Dentistry and Endodontics, Konaseema Institute of Medical Sciences & Research Foundation, Amalapuram, IND.",
"collective": null,
"firstname": "Treesa W",
"initials": "TW",
"lastname": "Gomez"
},
{
"affiliation": "Electrical Design, WSP Global, Abu Dhabi, ARE.",
"collective": null,
"firstname": "Justus W",
"initials": "JW",
"lastname": "Gomez"
},
{
"affiliation": "Conservative Dentistry and Endodontics, Rajas Dental College & Hospital, Tirunelveli, IND.",
"collective": null,
"firstname": "Rajesh",
"initials": "R",
"lastname": "Gopal"
}
] |
Cureus
| null |
32874798
|
Clinical Applications and Benefits of Using Closed-Incision Negative Pressure Therapy for Incision and Surrounding Soft Tissue Management: A Novel Approach for Comorbid Wounds.
| null | null | null | null | null | null |
null |
© 2024. The Author(s).
|
10.1038/s41598-024-66814-3
10.1056/NEJMoa041031
10.1007/s00261-018-1750-6
10.1371/journal.pone.0139661
10.1093/ndt/gfy389
10.1093/ndt/gfy163
10.1007/s00330-009-1619-8
10.1016/j.crad.2014.06.011
10.1093/ndt/gfz129
10.1093/ndt/gfy152
10.17219/acem/166512
10.1007/s00330-018-5911-3
10.21037/qims-20-842
10.1038/s41598-022-19009-7
10.1038/s41746-019-0104-2
10.1053/j.ajkd.2008.12.034
10.1002/jmri.21492
10.1002/jmri.20878
10.1093/ndt/gfy198
10.1016/j.media.2021.101960
10.3389/fphys.2017.00696
10.1038/srep30088
10.1590/0100-3984.2019.0086
10.1002/jmri.25252
10.1148/rg.265055711
10.1038/s41598-023-44539-z
10.1016/j.neuroimage.2017.02.035
10.1109/ACCESS.2019.2948430
10.3390/diagnostics12010116
10.1049/syb2.12031
10.1109/ACCESS.2019.2963053
10.1016/j.zemedi.2023.08.001
| null |
[
"Chronic kidney disease",
"Deep learning",
"Dixon-based T1-weighted image",
"Magnetic resonance imaging",
"Three-dimensional convolutional neural network"
] |
2024-07-10
|
A three-dimensional convolutional neural network model was developed to classify the severity of chronic kidney disease (CKD) using magnetic resonance imaging (MRI) Dixon-based T1-weighted in-phase (IP)/opposed-phase (OP)/water-only (WO) imaging. Seventy-three patients with severe renal dysfunction (estimated glomerular filtration rate [eGFR] < 30 mL/min/1.73 m
|
[
{
"affiliation": "Department of Radiology, Saitama Medical University, 38 Morohongou, Moroyama-machi, Iruma-gun, Saitama, Japan.",
"collective": null,
"firstname": "Keita",
"initials": "K",
"lastname": "Nagawa"
},
{
"affiliation": "Department of Radiology, Saitama Medical University, 38 Morohongou, Moroyama-machi, Iruma-gun, Saitama, Japan.",
"collective": null,
"firstname": "Yuki",
"initials": "Y",
"lastname": "Hara"
},
{
"affiliation": "Department of Radiology, Saitama Medical University, 38 Morohongou, Moroyama-machi, Iruma-gun, Saitama, Japan. [email protected].",
"collective": null,
"firstname": "Kaiji",
"initials": "K",
"lastname": "Inoue"
},
{
"affiliation": "Department of Radiology, Saitama Medical University, 38 Morohongou, Moroyama-machi, Iruma-gun, Saitama, Japan.",
"collective": null,
"firstname": "Yosuke",
"initials": "Y",
"lastname": "Yamagishi"
},
{
"affiliation": "Department of Radiology, Saitama Medical University, 38 Morohongou, Moroyama-machi, Iruma-gun, Saitama, Japan.",
"collective": null,
"firstname": "Masahiro",
"initials": "M",
"lastname": "Koyama"
},
{
"affiliation": "Department of Radiology, Saitama Medical University, 38 Morohongou, Moroyama-machi, Iruma-gun, Saitama, Japan.",
"collective": null,
"firstname": "Hirokazu",
"initials": "H",
"lastname": "Shimizu"
},
{
"affiliation": "Department of Radiology, Saitama Medical University, 38 Morohongou, Moroyama-machi, Iruma-gun, Saitama, Japan.",
"collective": null,
"firstname": "Koichiro",
"initials": "K",
"lastname": "Matsuura"
},
{
"affiliation": "Department of Radiology, Saitama Medical University, 38 Morohongou, Moroyama-machi, Iruma-gun, Saitama, Japan.",
"collective": null,
"firstname": "Iichiro",
"initials": "I",
"lastname": "Osawa"
},
{
"affiliation": "Department of Nephrology, Saitama Medical University, 38 Morohongou, Moroyama-machi, Iruma-gun, Saitama, Japan.",
"collective": null,
"firstname": "Tsutomu",
"initials": "T",
"lastname": "Inoue"
},
{
"affiliation": "Department of Nephrology, Saitama Medical University, 38 Morohongou, Moroyama-machi, Iruma-gun, Saitama, Japan.",
"collective": null,
"firstname": "Hirokazu",
"initials": "H",
"lastname": "Okada"
},
{
"affiliation": "School of Biomedical Engineering, Faculty of Health and Medical Care, Saitama Medical University, 38 Morohongou, Moroyama-machi, Iruma-gun, Saitama, Japan.",
"collective": null,
"firstname": "Naoki",
"initials": "N",
"lastname": "Kobayashi"
},
{
"affiliation": "Department of Radiology, Saitama Medical University, 38 Morohongou, Moroyama-machi, Iruma-gun, Saitama, Japan.",
"collective": null,
"firstname": "Eito",
"initials": "E",
"lastname": "Kozawa"
}
] |
Scientific reports
| null |
38982238
23989362
15385656
16447092
30151714
26430736
30608554
30137580
19789876
25062924
31257440
30137584
37341174
30560361
33816165
36042326
31304376
19339088
18777528
17335025
30137583
33517241
28959212
27439482
33583975
27007212
16973772
37833438
28223187
35054287
34185395
37612178
|
Three-dimensional convolutional neural network-based classification of chronic kidney disease severity using kidney MRI.
| null | null | null | null | null | null |
null |
© 2025 The Author(s). Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.
|
10.1111/acel.70055
| null |
[
"CAR‐T",
"T cell exhaustion",
"T cell senescence",
"immune checkpoints",
"immune rejuvenation",
"immunosenescence",
"immunotherapy",
"senolytic therapy",
"solid tumors"
] |
2025-04-03
|
Immunotherapy has transformed the landscape of cancer treatment, with T cell-based strategies at the forefront of this revolution. However, the durability of these responses is frequently undermined by two intertwined phenomena: T cell exhaustion and senescence. While exhaustion is driven by chronic antigen exposure in the immunosuppressive tumor microenvironment, leading to a reversible state of diminished functionality, senescence reflects a more permanent, age- or stress-induced arrest in cellular proliferation and effector capacity. Together, these processes represent formidable barriers to sustained anti-tumor immunity. In this review, we dissect the molecular underpinnings of T cell exhaustion and senescence, revealing how these dysfunctions synergistically contribute to immune evasion and resistance across a range of solid tumors. We explore cutting-edge therapeutic approaches aimed at rewiring the exhausted and senescent T cell phenotypes. These include advances in immune checkpoint blockade, the engineering of "armored" CAR-T cells, senolytic therapies that selectively eliminate senescent cells, and novel interventions that reinvigorate the immune system's capacity for tumor eradication. By spotlighting emerging strategies that target both exhaustion and senescence, we provide a forward-looking perspective on the potential to harness immune rejuvenation. This comprehensive review outlines the next frontier in cancer immunotherapy: unlocking durable responses by overcoming the immune system's intrinsic aging and exhaustion, ultimately paving the way for transformative therapeutic breakthroughs.
|
[
{
"affiliation": "Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, California, USA.",
"collective": null,
"firstname": "Tesfahun Dessale",
"initials": "TD",
"lastname": "Admasu"
},
{
"affiliation": "Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, California, USA.\nKairos Pharma, Los Angeles, California, USA.",
"collective": null,
"firstname": "John S",
"initials": "JS",
"lastname": "Yu"
}
] |
Aging cell
| null |
40178455
|
Harnessing Immune Rejuvenation: Advances in Overcoming T Cell Senescence and Exhaustion in Cancer Immunotherapy.
| null | null | null | null | null | null |
null | null |
10.1177/1526602815582211
| null |
[
"abdominal aortic aneurysm",
"chimney graft",
"emergent repair",
"endoleak",
"endovascular sealing system",
"parallel graft",
"pararenal aneurysm",
"ruptured aneurysm"
] |
2015-04-19
| null |
[
{
"affiliation": "St George's Vascular Institute, St George's University of London, London, UK.",
"collective": null,
"firstname": "Ian M",
"initials": "IM",
"lastname": "Loftus"
},
{
"affiliation": "Department of Vascular and Endovascular Surgery, Ruprecht-Karls University Heidelberg, Heidelberg, Germany.",
"collective": null,
"firstname": "Dittmar",
"initials": "D",
"lastname": "Böckler"
}
] |
Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists
| null |
25887728
|
Commentary: endovascular aneurysm sealing and chimney grafts: an emergency kit for ruptured pararenal aortic aneurysms?
| null | null | null | null | null | null |
null | null |
10.47162/RJME.61.1.10
| null |
[] |
2020-08-05
|
Deaths caused by traumatic brain injury (TBI) increase in incidence every year worldwidely, mainly in developing countries. Thus, World Health Organization (WHO) estimates that in 2020, TBI will become the third main cause of death. In our study, we evaluated the deaths caused by TBI recorded within the Institute of Forensic Medicine of Craiova, Romania, between 2011 and 2017. Therefore, according to age, the cases were divided into two groups: people aged 0-18 years old (including 18 years old) and people aged over 18 years old (a total of 1005 cases, of which 971 were adults and 34 included in the age group 0-18 years old). In both groups, most patients were males from the rural area. In adults, falling was the main legal entity of the cases, followed by car accidents (which were the most common in children). In both groups, in car accidents, most of them were pedestrians and car occupants. Various aggressions (human, animal, self-injury) were found in 94 (9.68%) of the adult cases and in four (11.76%) cases of children. Another parameter under study was the blood alcohol concentration, being observed that most of the subjects with positive blood alcohol content died from car accidents. By evaluating the Glasgow Coma Scale (GCS) score as a prognostic factor, most of the subjects presented third and fourth degree coma at admission; still, 5.14% of the adult patients who deceased had GCS score 15 at admission, death occurring probably by developing some intracranial hematomas in time. Regarding the morphology of the lesions, most patients presented various forms of cranial fractures, 185 (19.05%) adults in association with extradural hemorrhages∕hematomas, but also there were four cases with extradural hematomas without any cranial fractures. In children, there was highlighted a single case of extradural hemorrhage under the fracture line. Seventy-eight percent of the adults and 44.12% of children presented subdural hematomas associated with other meningo-cerebral lesions. Also, 83.63% of the adults and 97% of children presented brain contusions. In both groups, brain laceration was observed in approximately 50% of the cases.
|
[
{
"affiliation": "Department of Medical Informatics and Biostatistics, Department of Obstetrics and Gynecology, University of Medicine and Pharmacy of Craiova, Romania; [email protected], [email protected].",
"collective": null,
"firstname": "Răzvan Ştefan",
"initials": "RŞ",
"lastname": "Ţolescu"
},
{
"affiliation": null,
"collective": null,
"firstname": "Marian Valentin",
"initials": "MV",
"lastname": "Zorilă"
},
{
"affiliation": null,
"collective": null,
"firstname": "Mircea Sebastian",
"initials": "MS",
"lastname": "Şerbănescu"
},
{
"affiliation": null,
"collective": null,
"firstname": "Kamal Constantin",
"initials": "KC",
"lastname": "Kamal"
},
{
"affiliation": null,
"collective": null,
"firstname": "George Lucian",
"initials": "GL",
"lastname": "Zorilă"
},
{
"affiliation": null,
"collective": null,
"firstname": "Ilie",
"initials": "I",
"lastname": "Dumitru"
},
{
"affiliation": null,
"collective": null,
"firstname": "Charoula",
"initials": "C",
"lastname": "Florou"
},
{
"affiliation": null,
"collective": null,
"firstname": "Laurenţiu",
"initials": "L",
"lastname": "Mogoantă"
},
{
"affiliation": null,
"collective": null,
"firstname": "Ion Alexandru",
"initials": "IA",
"lastname": "Văduva"
},
{
"affiliation": null,
"collective": null,
"firstname": "Liliana",
"initials": "L",
"lastname": "Stanca"
},
{
"affiliation": null,
"collective": null,
"firstname": "Roxana Eugenia",
"initials": "RE",
"lastname": "Zăvoi"
}
] |
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
| null |
32747899
29122524
29701556
18162698
23127680
16983222
25184881
9167458
31875163
11535895
23822874
24249325
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27651867
32047603
22035678
25702209
27739577
29601944
19033832
31827423
21544045
22308963
28301451
18427091
21149359
31563989
16887941
16311842
25918580
18048036
18627252
20168229
24315370
32038140
29686672
28111406
19858964
23340166
26729611
29253420
22678449
12637181
18469656
27313514
28958355
26537996
27516010
29556636
21068620
26230219
31778395
30931989
31719807
31334245
26825613
26495403
25534914
29863612
31986958
|
Severe traumatic brain injury (TBI) - a seven-year comparative study in a Department of Forensic Medicine.
| null | null | null | null | null | null |
null |
Copyright © 2022 JCBN.
|
10.3164/jcbn.21-54
| null |
[
"apoptosis",
"edible bird’s nest extract",
"skin damage",
"superoxide dismutase",
"ultraviolet"
] |
2022-01-25
|
The purpose of the present study was to examine whether daily intake of edible bird's nest extract reduced ultraviolet-induced damage to skin. Twenty-one female HR-1/Hos mice were divided into control (C,
|
[
{
"affiliation": "Kyoto Institute of Nutrition & Pathology, 7-2 Furuikedani Tachikawa, Ujitawara, Kyoto 610-0231, Japan.",
"collective": null,
"firstname": "Shinya",
"initials": "S",
"lastname": "Masuda"
},
{
"affiliation": "Life Science Division, Combi Corporation, Nishibori, Sakura-ku, Saitama 338-0832, Japan.",
"collective": null,
"firstname": "Yuko",
"initials": "Y",
"lastname": "Makioka-Itaya"
},
{
"affiliation": "Life Science Division, Combi Corporation, Nishibori, Sakura-ku, Saitama 338-0832, Japan.",
"collective": null,
"firstname": "Tetsuo",
"initials": "T",
"lastname": "Ijichi"
},
{
"affiliation": "Kyoto Institute of Nutrition & Pathology, 7-2 Furuikedani Tachikawa, Ujitawara, Kyoto 610-0231, Japan.",
"collective": null,
"firstname": "Takamitsu",
"initials": "T",
"lastname": "Tsukahara"
}
] |
Journal of clinical biochemistry and nutrition
| null |
35068679
17035304
3803396
3497769
30206602
21389609
6505037
29466611
18248501
33041515
32801466
25308934
25920003
12126755
29099803
9886257
25185865
31524073
32116666
30186358
29479160
26341858
26362110
17524122
21992551
|
Edible bird's nest extract downregulates epidermal apoptosis and helps reduce damage by ultraviolet radiation in skin of hairless mice.
| null | null | null | null | null | null |
null | null |
10.1007/s00392-002-0802-6
| null |
[] |
2002-09-11
|
We report the case of 65 year old male patient with extreme heart enlargement. The patient was admitted to the hospital due to acute bleeding from varicose veins of the cardia. The endoscopic treatment by means of hemostatic clips and fibrine was successful. However the patient died two weeks later without having any complaints. The heart of the patient weighed 1350 g. Multiple coronary bypasses were found. There was also a recent myocardial infarction. The adoptive pathophysiologic changes accompanying extreme cardiomegaly are discussed. Numerous cases have been recorded of unusually large hearts, which in a few instances have even exceeded the one reported here. The analysis of observations reported in the literature reveals that rheumatic myocarditis and syphilitic aortitis were responsible for the majority of cases with extreme cardiac hypertrophy. Valvular deformities were also frequent findings. The occurrence of extreme cardiac enlargement in an elderly patient associated with multiple coronary bypasses has been not described so far.
|
[
{
"affiliation": "Department of Pathology, Hegau-Klinikum Singen 78207 Singen, Germany.",
"collective": null,
"firstname": "I",
"initials": "I",
"lastname": "Sinicina"
},
{
"affiliation": null,
"collective": null,
"firstname": "B",
"initials": "B",
"lastname": "Helpap"
}
] |
Zeitschrift fur Kardiologie
| null |
12219700
|
[Extreme cardiomegaly].
| null | null | null | null | null | null |
null | null |
10.4269/ajtmh.2001.64.6
| null |
[] |
2001-06-27
|
The influence of alpha(+)-thalassemia on malaria in pregnancy was assessed in a cross-sectional study of 530 women in Ghana. Plasmodial infections, alpha(+)-thalassemia, serum levels of C-reactive protein, and antimalarial drugs in urine were determined. The alpha-globin genotypes did not correlate with the prevalence of Plasmodium falciparum-infection and parasite densities. However, Plasmodium malariae tended to be more frequent in alpha(+)-thalassemic women (P = 0.05). Excluding women with residual antimalarials, a significant excess of P. malariae was observed in alpha(+)-thalassemic individuals. Febrile responses (P = 0.05) and inflammation (CRP > 0.6 mg/dl, P = 0.06) appeared to be less common in infected alpha(+)-thalassemic women and were also comparatively rare in parasitemic individuals who harbored double species infections with P. falciparum and P. malariae. Plasmodium malariae may influence the pathogenesis of falciparum malaria leading to a low prevalence of inflammation and febrile responses in alpha(+)-thalassemic women.
|
[
{
"affiliation": "Institute of Tropical Medicine Berlin, Medical Faculty Charité, Humboldt-University Berlin, Germany.",
"collective": null,
"firstname": "F P",
"initials": "FP",
"lastname": "Mockenhaupt"
},
{
"affiliation": null,
"collective": null,
"firstname": "B",
"initials": "B",
"lastname": "Rong"
},
{
"affiliation": null,
"collective": null,
"firstname": "H",
"initials": "H",
"lastname": "Till"
},
{
"affiliation": null,
"collective": null,
"firstname": "W N",
"initials": "WN",
"lastname": "Thompson"
},
{
"affiliation": null,
"collective": null,
"firstname": "U",
"initials": "U",
"lastname": "Bienzle"
}
] |
The American journal of tropical medicine and hygiene
| null |
11425165
|
Short report: increased susceptibility to Plasmodium malariae in pregnant alpha(+)-thalassemic women.
| null | null | null | null | null | null |
null | null | null | null |
[] |
2013-02-05
|
We present a case of an extensive, purpuric eruption on the lower leg with peculiar clinical findings in 55-year-old woman with rheumatoid arthritis. The purpuric lesions were present unilaterally on the left lower leg, where prominent varices and telangiectasia were noted. Histological examination revealed a perivascular infiltration of lymphocytic cells and eosinophils and extravasation of erythrocytes in the upper and middle dermis. There was no evidence of vasculitis. The eruption responded well to treatment with hemostatic agents and elastic stockings. Based on the clinical and histological findings, we concluded that the main pathophysiology of the purpuric eruption is an extravasation of erythrocytes related to increased venous pressure secondary to venous stasis.
|
[
{
"affiliation": "Kobe University Graduate School of Medicine Kobe, Hyogo, Japan.",
"collective": null,
"firstname": "Satoshi",
"initials": "S",
"lastname": "Ogawa"
},
{
"affiliation": null,
"collective": null,
"firstname": "Masahiro",
"initials": "M",
"lastname": "Oka"
},
{
"affiliation": null,
"collective": null,
"firstname": "Makoto",
"initials": "M",
"lastname": "Kunisada"
},
{
"affiliation": null,
"collective": null,
"firstname": "Chikako",
"initials": "C",
"lastname": "Nishigori"
}
] |
Dermatology online journal
| null |
23374958
|
Unilateral lower leg purpura.
| null | null | null | null | null | null |
null |
Copyright © 2025 American Urogynecologic Society. All rights reserved.
|
10.1097/SPV.0000000000001624
10.1002/nau
10.1023/A:1008836922089
10.1016/j.juro.2012.09.079
10.1007/s11934-014-0479-1
10.1016/j.juro.2017.07.010
10.1007/s11934-010-0128-2
10.5435/jaaosglobal-d-17-00088
10.1136/emj.18.3.205
10.1001/jama.2022.21022
10.1159/000513937
|
Thirty-nine women were enrolled, with 20 receiving LP and 19 patients receiving PP. Lower 100-mm visual analog scale pain score was seen in the LP group (45 ± 17 with LP vs 61 ± 21 with PP, P = 0.018). This difference was statistically and clinically significantly different between groups. The total injectable lidocaine, patient satisfaction, and progression to permanent implant were similar between groups.
|
[] |
2025-02-27
|
Improving patient comfort during percutaneous nerve evaluation (PNE), a trial procedure for sacral neuromodulation, is essential.
The aim of the study was to determine whether the use of a lidocaine patch (LP) prior to PNE procedure improves the pain associated with PNE.
This double-masked, randomized controlled trial compared a 4% LP to placebo patch (PP) immediately prior to PNE. Female patients ≥18 years of age were included if they were undergoing an office PNE, performed bilaterally and without fluoroscopy, for any indication. Either a lidocaine or placebo patch was placed over the sacrum 30 minutes prior to PNE. Additional local anesthesia with 2% lidocaine without epinephrine was administered per surgeon discretion. All patients received some volume of injectable lidocaine with their procedures. Secondary outcomes included volume of injectable lidocaine used, progression to a permanent implant, amplitude of perineal sensation, and patient satisfaction.
Thirty-nine women were enrolled, with 20 receiving LP and 19 patients receiving PP. Lower 100-mm visual analog scale pain score was seen in the LP group (45 ± 17 with LP vs 61 ± 21 with PP, P = 0.018). This difference was statistically and clinically significantly different between groups. The total injectable lidocaine, patient satisfaction, and progression to permanent implant were similar between groups.
Patients experienced clinically and statistically significantly less pain at the time of PNE with a preprocedural LP when compared to placebo, despite similar use of local anesthetic. Satisfaction rates were high among all patients.
|
[
{
"affiliation": "From the Division of Urogynecology and Reconstructive Pelvic Surgery, Department of OBGYN and Women's Health, University of Louisville, Louisville, KY.",
"collective": null,
"firstname": "Rodger W",
"initials": "RW",
"lastname": "Rothenberger"
},
{
"affiliation": "University of Louisville School of Medicine, Louisville, KY.",
"collective": null,
"firstname": "Taylen",
"initials": "T",
"lastname": "Henry"
},
{
"affiliation": "From the Division of Urogynecology and Reconstructive Pelvic Surgery, Department of OBGYN and Women's Health, University of Louisville, Louisville, KY.",
"collective": null,
"firstname": "Laurel",
"initials": "L",
"lastname": "Carbone"
},
{
"affiliation": "University of Louisville School of Public Health and Information Sciences, Louisville, KY.",
"collective": null,
"firstname": "Jeremy T",
"initials": "JT",
"lastname": "Gaskins"
},
{
"affiliation": "From the Division of Urogynecology and Reconstructive Pelvic Surgery, Department of OBGYN and Women's Health, University of Louisville, Louisville, KY.",
"collective": null,
"firstname": "Ankita",
"initials": "A",
"lastname": "Gupta"
},
{
"affiliation": "From the Division of Urogynecology and Reconstructive Pelvic Surgery, Department of OBGYN and Women's Health, University of Louisville, Louisville, KY.",
"collective": null,
"firstname": "Sean",
"initials": "S",
"lastname": "Francis"
},
{
"affiliation": "From the Division of Urogynecology and Reconstructive Pelvic Surgery, Department of OBGYN and Women's Health, University of Louisville, Louisville, KY.",
"collective": null,
"firstname": "Stacy M",
"initials": "SM",
"lastname": "Lenger"
}
] |
Urogynecology (Philadelphia, Pa.)
| null |
40013530
|
Supplemental Lidocaine Patches Prior to Percutaneous Nerve Evaluation, a Randomized Trial.
| null | null | null | null | null | null |
null |
Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.
|
10.1097/MD.0000000000036977
| null |
[] |
2024-02-02
|
Congenital heart disease (CHD) is the most common birth defect and an important cause of noninfectious deaths in infants and children. It has high prevalence globally, placing an enormous burden on society and families. Studies of individuals with hereditary or sporadic CHD have provided strong evidence for its genetic basis. The aim of this study was to identify causative gene variants in a Chinese family with congenital heart disease.
Three generations of a CHD family were recruited. Proband III.9 was diagnosed with congenital heart disease at age 11 months, and the echocardiogram showed arterial ductus arteriosus, with a left-to-right shunt at the level of the arteries. Precedent III.10 was a twin of Proband III.9 who was diagnosed with congenital heart disease at age 11 months, in whom the echocardiogram revealed an arterial ductus arteriosus, an unenclosed patent ductus arteriosus, and a left to right shunt at the level of the arteries (second figure). III.8 was diagnosed with congenital heart disease at age 15, but echocardiography in this study showed no abnormalities. No cardiac abnormalities were detected in any of his parents, grandparents, or maternal grandparents. We performed whole-exome sequencing on CHD sufferers and their unexpressing family members to investigate the genetic causes of CHD in this family line. Exome sequencing identified 4 mutation sites in this family line. The variant c.3245A>G (p.His1082Arg) of the AMER1 gene was consistent with concomitant X-chromosome recessive inheritance, the variant c.238G>C (p.Val80Leu) of the KCNE1 gene was consistent with autosomal accessory inheritance, and the other 2 variants did not conform to the law of the mode of inheritance of the disease.
The first identified variant, c.3245A>G (p.His1082Arg) of the AMER1 gene, with X-chromosome recessive inheritance, and the variant c.238G>C (p.Val80Leu) of the KCNE1 gene, which has been reported as autosomal dominant, may be the causative agent of CHD in this family line. These findings broaden the genetic scope of congenital heart disease and could help in the development of targeted drugs for the treatment of congenital heart disease.
|
[
{
"affiliation": "Department of Pathophysiology, Basic Medicine College of Inner Mongolia Medical University, Hohhot, China.\nRehabilitation Department, Ordos Central Hospital, Ordos, China.",
"collective": null,
"firstname": "Li",
"initials": "L",
"lastname": "Chang"
},
{
"affiliation": "Department of Pathophysiology, Basic Medicine College of Inner Mongolia Medical University, Hohhot, China.\nRehabilitation Department, Ordos Central Hospital, Ordos, China.",
"collective": null,
"firstname": "Renhui",
"initials": "R",
"lastname": "Ji"
},
{
"affiliation": "Rehabilitation Department, Ordos Central Hospital, Ordos, China.\nDepartment of Pediatrics, Ordos Central Hospital, Ordos, China.",
"collective": null,
"firstname": "Rina",
"initials": "R",
"lastname": "Sa"
},
{
"affiliation": "Department of Pediatrics, Ordos Central Hospital, Ordos, China.",
"collective": null,
"firstname": "Jiletu",
"initials": "J",
"lastname": "Huge"
},
{
"affiliation": "Department of Pathophysiology, Basic Medicine College of Inner Mongolia Medical University, Hohhot, China.\nRehabilitation Department, Ordos Central Hospital, Ordos, China.\nFoundational and Translational Medical Research Center, Department of Allergy and General Surgery, Hohhot First Hospital, Hohhot, China.",
"collective": null,
"firstname": "Caiyan",
"initials": "C",
"lastname": "An"
}
] |
Medicine
| null |
38306576
|
Whole-exome sequencing of pathogenic genes in a family with congenital heart disease: A case report.
| null | null | null | null | null | null |
null |
© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
|
10.1007/s10943-022-01629-y
10.1108/jwl-11-2015-0086
10.1016/j.envc.2021.100088
10.1111/1467-8551.12233
10.1108/wjemsd-01-2017-0002
10.1108/IJOES-01-2017-0003
10.1108/JGR-07-2016-0020
10.3390/su122410342
10.20900/jsr20190011
10.1177/0898010105278929
10.1111/j.1525-1438.2005.00248.x
10.3389/fpsyg.2020.01997
10.1002/bse.506
10.1007/s10551-014-2337-y
10.1016/j.jclepro.2013.09.050
10.1080/02604020903423527
10.1097/01.hnp.0000287986.17344.02
10.1002/9780470712184.ch9
10.1007/s10551-012-1425-0
10.2308/accr.00000005
10.1136/bmj.309.6964.1286
10.1080/14766080709518646
10.1002/bse.323
10.1080/13674670310001602490
10.1080/14766086.2010.524983
10.1177/1523422310394757
10.1177/0022167817741041
10.1080/14766086.2019.1656665
10.1177/1056492604265218
10.1504/ijie.2016.078633
10.1177/135910539900400309
10.5465/AME.2003.10025194
10.1136/bmj.327.7414.557
10.1108/IJPDLM-06-2013-0175
10.1177/1049732305276687
10.4135/9781412985031
10.1002/smj.2268
10.2519/jospt.2011.3333
10.1007/s10943-017-0379-z
10.1108/sajbs-07-2020-0258
10.1007/s10902-013-9431-1
10.2106/JBJS.D.03049
10.1037/a0024603
10.3389/fpsyg.2019.00377
10.1016/s0921-3449(04)00120-x
10.1080/09637494.2019.1702410
10.1371/journal.pone.0249702
10.1136/bmj.322.7300.1479
10.1017/s0144686x00001896
10.1016/S2212-5671(15)01678-0
10.1037/rel0000068
10.1590/1516-4446-2013-1255
10.1007/s10943-012-9612-y
10.3390/su12020470
10.1108/02683949410070151
10.2147/PRBM.S112129
10.1007/s10551-008-9965-z
10.1007/s10865-009-9223-6
10.1016/j.jsis.2009.06.001
10.1089/jpm.2009.0142
10.1089/jpm.2014.9427
10.1111/j.1468-2370.2009.00257.x
10.1002/j.2161-007x.1999.tb00144.x
10.1007/s10668-018-0120-4
10.1080/09669582.2017.1409229
10.1016/j.ecolecon.2003.10.017
10.1007/s10551-014-2246-0
10.1037/0033-2909.118.2.183
10.14431/aw.2020.9.36.3.91
10.1108/JIMA-08-2018-0140
10.1016/j.jwb.2009.08.002
10.1001/jama.273.5.408
10.1080/10437797.2013.812460
10.21844/pajmes.v10i02.10574
10.1080/1367467032000157981
10.3390/su13115965
10.1007/s10551-013-1660-z
10.3390/su13042377
10.1080/14766086.2013.832359
10.1504/MEJM.2019.10019531
10.1108/ijssp-06-2020-0211
10.9770/jssi.2017.7.2(13)
10.32479/ijeep.10803
10.1080/14766086.2019.1574598
10.1177/135910539900400314
10.1111/1467-8551.00375
10.18314/abne.v1i1.1240
10.1007/s10943-012-9642-5
10.1177/0022167802422003
10.1016/j.energy.2006.09.016
| null |
[
"Sustainability",
"Sustainable development",
"Wellbeing meta-analysis",
"Workplace spirituality"
] |
2022-09-02
|
Sustaining sustainability is now a matter of deep interest among academics and social scientists. There is an emerging opinion that there is a definite need to add spirituality as the fourth dimension to sustainability. The current meta-analytic study examined this aspect. The study used meta-analysis to examine the relationship between spirituality and sustainability. The research conducted using R-program has meticulously followed all the established protocols and rules of thumb regarding meta-analysis. The analysis was based on 34 studies identified from a preliminary search that yielded 1131 records retrieved from various databases. The study results show that spirituality has the potential to sustain sustainability. Further research could be carried out using more studies, as literature is only emerging in this area. It is expected that the present work will trigger further research on this exciting and fecund topic.
|
[
{
"affiliation": "College of Business Administration, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia. [email protected].",
"collective": null,
"firstname": "M M",
"initials": "MM",
"lastname": "Sulphey"
}
] |
Journal of religion and health
| null |
36048355
16117349
16251489
16174220
17728565
7718048
22021607
16204405
30873082
33857211
24839090
22592500
27574475
19639404
19807235
24842136
22021598
22965652
|
A Meta-analytic Literature Study on the Relationship Between Workplace Spirituality and Sustainability.
| null | null | null | null | null | null |
null |
Copyright © 2018 Elsevier Ltd. All rights reserved.
|
10.1016/j.addbeh.2017.12.031
|
The analyses revealed the presence of comparative optimism in assessing both health and addiction risks among smokeless tobacco users. Comparative optimism was negatively correlated with most cessation information-seeking variables. Health bias (the health risk rating gap between the subject's own tobacco product and cigarettes) was associated with decreased intent to use cessation support. However, the health bias and addiction bias (the addiction risk rating gap between the subject's own tobacco product and cigarettes) were not consistent predictors of all cessation information-seeking variables, when covariates of socio-demographics and tobacco use status were included. In addition, positive correlations between health bias and past/recent cessation-information searches were observed.
|
[
"Cessation",
"HINTS",
"Information-seeking",
"Optimistic bias",
"Smokeless tobacco"
] |
2018-01-08
|
This research examined (1) smokeless tobacco users' comparative optimism in assessing the health and addiction risks of their own product in comparison with cigarettes, and (2) the effects of comparative optimism on cessation information-seeking.
A nationally-representative sample from the 2015 Health Information National Trends Survey (HINTS)-FDA was employed.
The analyses revealed the presence of comparative optimism in assessing both health and addiction risks among smokeless tobacco users. Comparative optimism was negatively correlated with most cessation information-seeking variables. Health bias (the health risk rating gap between the subject's own tobacco product and cigarettes) was associated with decreased intent to use cessation support. However, the health bias and addiction bias (the addiction risk rating gap between the subject's own tobacco product and cigarettes) were not consistent predictors of all cessation information-seeking variables, when covariates of socio-demographics and tobacco use status were included. In addition, positive correlations between health bias and past/recent cessation-information searches were observed.
Optimisic biases may negatively influence cessation behaviors not only directly but also indirectly by influencing an important moderator, cessation information-seeking. Future interventions should prioritize dispelling the comparative optimism in perceiving risks of smokeless tobacco use, as well as provide more reliable cessation information specific to smokeless tobacco users.
|
[
{
"affiliation": "The Department of Communication, University of Maryland, College Park, MD, USA. Electronic address: [email protected].",
"collective": null,
"firstname": "Jungmi",
"initials": "J",
"lastname": "Jun"
},
{
"affiliation": "The Department of Communication, University of Maryland, College Park, MD, USA.",
"collective": null,
"firstname": "Xiaoli",
"initials": "X",
"lastname": "Nan"
}
] |
Addictive behaviors
| null |
29306721
|
Comparative risk assessment and cessation information seeking among smokeless tobacco users.
| null | null | null | null | null | null |
Overall, the findings demonstrate that OLE and OLR have both promising potential with regard to the inhibition of gastric hemorrhage and lesions.
| null |
10.22038/IJBMS.2024.76135.16474
|
This study verified that OLE and purified OLR protect from ethanol-induced gastric ulceration and damage, evidenced by the significant decrease in gastric ulcer urea (by 74 and 58% respectively) and stomach mucus content (by 169 and 87% respectively). In addition, the ulcer index (UI) and curative index (CI) levels in the stomach of the rats treated with this supplement were also suppressed by 55 and 46%, respectively. OLE and OLR also decreased the gastric myeloperoxidase (MPO) activity and ameliorated the nitric oxide (NO) content. OLE and OL also ingestion suppressed gastric tumor necrosis factor-alpha (TNF-α) and interleukin (IL-6) rates. Macroscopic and histological findings revealed that OLE and OLR protect from gastric hemorrhage, severe disruption of the gastric mucosa, and neutrophil infiltration.
|
[
"Inflammation",
"Nitric oxide",
"Olea oleaster",
"Oleuropein",
"Ulcer"
] |
2024-06-24
|
Evaluating the effect of fresh Oleaster leaf extract (OLE) and purified oleuropein (OLR) on ethanol-induced gastric ulcers in rats. HPLC analysis demonstrates the presence of various polyphenol compounds such as ligstroside, luteolin derivative, oleuropein, and comselogoside.
Gastric ulcer was induced by administration of ethanol by the gastric gavage route. The olive leaf extract was analyzed by HPLC-PDA-ESI-MS, and OLR was purified. These two compounds were given 2 hr before gastric ulcer induction by ethanol.
This study verified that OLE and purified OLR protect from ethanol-induced gastric ulceration and damage, evidenced by the significant decrease in gastric ulcer urea (by 74 and 58% respectively) and stomach mucus content (by 169 and 87% respectively). In addition, the ulcer index (UI) and curative index (CI) levels in the stomach of the rats treated with this supplement were also suppressed by 55 and 46%, respectively. OLE and OLR also decreased the gastric myeloperoxidase (MPO) activity and ameliorated the nitric oxide (NO) content. OLE and OL also ingestion suppressed gastric tumor necrosis factor-alpha (TNF-α) and interleukin (IL-6) rates. Macroscopic and histological findings revealed that OLE and OLR protect from gastric hemorrhage, severe disruption of the gastric mucosa, and neutrophil infiltration.
Overall, the findings demonstrate that OLE and OLR have both promising potential with regard to the inhibition of gastric hemorrhage and lesions.
|
[
{
"affiliation": "Laboratory of Bioresources, Integrative Biology and Exploiting, Higher Institute of Biotechnology of Monastir, University of Monastir, Tunisia.",
"collective": null,
"firstname": "Fatiha",
"initials": "F",
"lastname": "Abdellah"
},
{
"affiliation": "Laboratory of Research on Local Animal Products, Ibn-Khaldoun University, Tiaret, Algeria.",
"collective": null,
"firstname": "Tayeb",
"initials": "T",
"lastname": "Silarbi"
},
{
"affiliation": "Biology Department, Faculty of Sciences and Arts of Muhayil Asir, King Khaled University, Saudi Arabia.",
"collective": null,
"firstname": "Ferjeni",
"initials": "F",
"lastname": "Zouidi"
},
{
"affiliation": "Laboratory of Bioresources, Integrative Biology and Exploiting, Higher Institute of Biotechnology of Monastir, University of Monastir, Tunisia.",
"collective": null,
"firstname": "Khaled",
"initials": "K",
"lastname": "Hamden"
}
] |
Iranian journal of basic medical sciences
| null |
38911236
21966156
33050668
34580595
36716661
37144196
32950497
37396940
37970441
36594058
38234664
28804611
37605721
38629099
36478797
32536285
37967031
34527009
35214813
37273043
31404064
33424990
32351592
33134135
6276474
11178938
33925051
35276233
33034707
30241383
31578603
31365237
17963838
33105803
37375384
34574160
35406845
24072502
36228371
37102636
33922167
22550543
35656183
33237043
33274185
30884286
30426792
38276520
32544520
|
Effects of
| null | null | null | null | null | null |
null |
© 2024. The Author(s).
|
10.1186/s41512-024-00172-6
10.1002/trc2.12295
10.3233/JAD-220046
10.1080/14737175.2023.2284305
10.1212/WNL.0000000000004826
10.1001/jamaneurol.2021.5205
10.1186/s12916-014-0241-z
10.3233/JAD-190670
10.1016/j.jalz.2011.03.008
10.1007/s12021-014-9235-4
10.1016/j.nicl.2014.10.009
10.3389/fnins.2021.656808
10.1007/s11357-020-00176-2
10.1186/s13195-017-0297-z
10.31887/DCNS.2009.11.2/cqiu
10.1111/j.1532-5415.1995.tb06377.x
10.3389/fnagi.2013.00058
10.1007/s10072-018-3507-y
10.1111/j.1553-2712.1996.tb03538.x
10.1002/sim.7992
10.3389/fnagi.2022.840386
10.1016/0022-3956(75)90026-6
10.1080/87565649109540545
10.1007/s10072-011-0607-3
10.3389/fnins.2021.647783
10.1186/s13195-020-00689-0
10.3233/JAD-170128
10.1186/s13195-019-0550-8
10.11613/BM.2016.034
10.11613/BM.2016.034
10.1093/aje/kwj063
10.1186/s41512-018-0037-2
10.1001/jama.1982.03320430047030
10.1177/1536867X1001000303
10.1097/EDE.0b013e3181c30fb2
10.1002/sim.4067
10.1200/JCO.2007.12.9791
10.1016/j.lanwpc.2023.100836
10.1159/000518581
10.1016/S2666-7568(23)00216-7
| null |
[
"Alzheimer’s disease",
"Biomarker",
"Dementia",
"Longitudinal study",
"Mild cognitive impairment",
"Prediction model",
"Statistical analysis plan"
] |
2024-07-26
|
In recent years, significant efforts have been directed towards the research and development of disease-modifying therapies for dementia. These drugs focus on prodromal (mild cognitive impairment, MCI) and/or early stages of Alzheimer's disease (AD). Literature evidence indicates that a considerable proportion of individuals with MCI do not progress to dementia. Identifying individuals at higher risk of developing dementia is essential for appropriate management, including the prescription of new disease-modifying therapies expected to become available in clinical practice in the near future.
The ongoing INTERCEPTOR study is a multicenter, longitudinal, interventional, non-therapeutic cohort study designed to enroll 500 individuals with MCI aged 50-85 years. The primary aim is to identify a biomarker or a set of biomarkers able to accurately predict the conversion from MCI to AD dementia within 3 years of follow-up. The biomarkers investigated in this study are neuropsychological tests (mini-mental state examination (MMSE) and delayed free recall), brain glucose metabolism ([18F]FDG-PET), MRI volumetry of the hippocampus, EEG brain connectivity, cerebrospinal fluid (CSF) markers (p-tau, t-tau, Aβ1-42, Aβ1-42/1-40 ratio, Aβ1-42/p-Tau ratio) and APOE genotype. The baseline visit includes a full cognitive and neuropsychological evaluation, as well as the collection of clinical and socio-demographic information. Prognostic models will be developed using Cox regression, incorporating individual characteristics and biomarkers through stepwise selection. Model performance will be evaluated in terms of discrimination and calibration and subjected to internal validation using the bootstrapping procedure. The final model will be visually represented as a nomogram.
This paper contains a detailed description of the statistical analysis plan to ensure the reproducibility and transparency of the analysis. The prognostic model developed in this study aims to identify the population with MCI at higher risk of developing AD dementia, potentially eligible for drug prescriptions. The nomogram could provide a valuable tool for clinicians for risk stratification and early treatment decisions.
ClinicalTrials.gov NCT03834402. Registered on February 8, 2019.
|
[
{
"affiliation": "National Centre for Disease Prevention and Health Promotion, Italian National Institute of Health, Rome, Italy. [email protected].",
"collective": null,
"firstname": "Flavia L",
"initials": "FL",
"lastname": "Lombardo"
},
{
"affiliation": "National Centre for Disease Prevention and Health Promotion, Italian National Institute of Health, Rome, Italy.",
"collective": null,
"firstname": "Patrizia",
"initials": "P",
"lastname": "Lorenzini"
},
{
"affiliation": "National Center for Drug Research and Evaluation, Italian National Institute of Health, Rome, Italy.",
"collective": null,
"firstname": "Flavia",
"initials": "F",
"lastname": "Mayer"
},
{
"affiliation": "National Center for Drug Research and Evaluation, Italian National Institute of Health, Rome, Italy.",
"collective": null,
"firstname": "Marco",
"initials": "M",
"lastname": "Massari"
},
{
"affiliation": "Department of Neuroscience, Italian National Institute of Health, Rome, Italy.",
"collective": null,
"firstname": "Paola",
"initials": "P",
"lastname": "Piscopo"
},
{
"affiliation": "National Centre for Disease Prevention and Health Promotion, Italian National Institute of Health, Rome, Italy.",
"collective": null,
"firstname": "Ilaria",
"initials": "I",
"lastname": "Bacigalupo"
},
{
"affiliation": "National Centre for Disease Prevention and Health Promotion, Italian National Institute of Health, Rome, Italy.",
"collective": null,
"firstname": "Antonio",
"initials": "A",
"lastname": "Ancidoni"
},
{
"affiliation": "National Centre for Disease Prevention and Health Promotion, Italian National Institute of Health, Rome, Italy.",
"collective": null,
"firstname": "Francesco",
"initials": "F",
"lastname": "Sciancalepore"
},
{
"affiliation": "National Centre for Disease Prevention and Health Promotion, Italian National Institute of Health, Rome, Italy.",
"collective": null,
"firstname": "Nicoletta",
"initials": "N",
"lastname": "Locuratolo"
},
{
"affiliation": "Neurology Department and Brain Health Service, Fondazione IRCCS San Gerardo Dei Tintori, Monza, Italy.",
"collective": null,
"firstname": "Giulia",
"initials": "G",
"lastname": "Remoli"
},
{
"affiliation": "Department of Biomedical, Metabolic, and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.",
"collective": null,
"firstname": "Simone",
"initials": "S",
"lastname": "Salemme"
},
{
"affiliation": "University Institute of Advanced Studies IUSS Pavia, Pavia, Italy.\nIRCCS Mondino Foundation, Pavia, Italy.",
"collective": null,
"firstname": "Stefano",
"initials": "S",
"lastname": "Cappa"
},
{
"affiliation": "Vita-Salute San Raffaele University, Nuclear Medicine Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.",
"collective": null,
"firstname": "Daniela",
"initials": "D",
"lastname": "Perani"
},
{
"affiliation": "\"Associazione Italiana Malattia di Alzheimer\" - AIMA, Milan, Italy.",
"collective": null,
"firstname": "Patrizia",
"initials": "P",
"lastname": "Spadin"
},
{
"affiliation": "Fondazione IRCCS Istituto Neurologico \"Carlo Besta\", Milan, Italy.",
"collective": null,
"firstname": "Fabrizio",
"initials": "F",
"lastname": "Tagliavini"
},
{
"affiliation": "Laboratory of Neuroinformatics, IRCCS Istituto Centro San Giovanni Di Dio Fatebenefratelli, Brescia, Italy.",
"collective": null,
"firstname": "Alberto",
"initials": "A",
"lastname": "Redolfi"
},
{
"affiliation": "Neuropsychology Unit, IRCCS Istituto Centro San Giovanni Di Dio Fatebenefratelli, Brescia, Italy.",
"collective": null,
"firstname": "Maria",
"initials": "M",
"lastname": "Cotelli"
},
{
"affiliation": "Department of Neuroscience, Catholic University of Sacred Heart, Rome, Italy.\nMemory Clinic, Foundation Policlinico Agostino Gemelli IRCCS, Rome, Italy.",
"collective": null,
"firstname": "Camillo",
"initials": "C",
"lastname": "Marra"
},
{
"affiliation": "Memory Clinic, Foundation Policlinico Agostino Gemelli IRCCS, Rome, Italy.",
"collective": null,
"firstname": "Naike",
"initials": "N",
"lastname": "Caraglia"
},
{
"affiliation": "Brain Connectivity Laboratory, Department of Neuroscience and Neurorehabilitation, IRCCS San Raffaele, Rome, Italy.\nDepartment of Theoretical and Applied Sciences, eCampus University, Novedrate, Como, Italy.",
"collective": null,
"firstname": "Fabrizio",
"initials": "F",
"lastname": "Vecchio"
},
{
"affiliation": "Brain Connectivity Laboratory, Department of Neuroscience and Neurorehabilitation, IRCCS San Raffaele, Rome, Italy.\nDepartment of Theoretical and Applied Sciences, eCampus University, Novedrate, Como, Italy.",
"collective": null,
"firstname": "Francesca",
"initials": "F",
"lastname": "Miraglia"
},
{
"affiliation": "Memory Clinic, Foundation Policlinico Agostino Gemelli IRCCS, Rome, Italy.\nBrain Connectivity Laboratory, Department of Neuroscience and Neurorehabilitation, IRCCS San Raffaele, Rome, Italy.",
"collective": null,
"firstname": "Paolo Maria",
"initials": "PM",
"lastname": "Rossini"
},
{
"affiliation": "National Centre for Disease Prevention and Health Promotion, Italian National Institute of Health, Rome, Italy.",
"collective": null,
"firstname": "Nicola",
"initials": "N",
"lastname": "Vanacore"
},
{
"affiliation": null,
"collective": null,
"firstname": null,
"initials": null,
"lastname": null
}
] |
Diagnostic and prognostic research
| null |
39049042
|
Development of a prediction model of conversion to Alzheimer's disease in people with mild cognitive impairment: the statistical analysis plan of the INTERCEPTOR project.
| null | null | null | null | null | null |
Endoscopic ultrasound-guided gastroenterostomy represents a promising alternative to surgical gastrojejunostomy and duodenal stenting for the management of gastric outlet obstruction. The technique has evolved significantly, offering a less invasive and more effective treatment option.
|
© 2024 The Author(s). Digestive Endoscopy published by John Wiley & Sons Australia, Ltd on behalf of Japan Gastroenterological Endoscopy Society.
|
10.1111/den.14929
|
The development of EUS-guided gastroenterostomy has evolved significantly over the years, driven by device advancements and improved endoscopic techniques. Comparative studies have shown that the technique offers several advantages, including the ability to create an anastomosis without the need for surgery, reduced invasiveness, shorter hospital stays, and potentially improved patient outcomes as compared to duodenal stenting and surgical gastrojejunostomy.
|
[
"EUS‐gastroenterostomy",
"EUS‐gastrojejunostomy",
"endoscopic stenting",
"gastric outlet obstruction",
"laparoscopic gastrojejunostomy"
] |
2024-10-07
|
Gastrojejunostomy is a critical procedure for managing gastric outlet obstruction. While surgical gastrojejunostomy has traditionally been the standard approach, endoscopic ultrasound (EUS)-guided gastroenterostomy has emerged as a promising endoscopic alternative. This comprehensive review aims to explore the development, techniques, outcomes, and comparative effectiveness of EUS-guided gastroenterostomy in comparison to duodenal stenting and surgical gastrojejunostomy.
A comprehensive literature search was conducted using electronic databases to identify relevant studies published up to April 2024. The search included keywords related to EUS-guided gastrojejunostomy, surgical gastrojejunostomy, and duodenal stenting. Studies reporting on technical success, clinical success, complications, recurrence rates, quality of life, and long-term outcomes were included for analysis.
The development of EUS-guided gastroenterostomy has evolved significantly over the years, driven by device advancements and improved endoscopic techniques. Comparative studies have shown that the technique offers several advantages, including the ability to create an anastomosis without the need for surgery, reduced invasiveness, shorter hospital stays, and potentially improved patient outcomes as compared to duodenal stenting and surgical gastrojejunostomy.
Endoscopic ultrasound-guided gastroenterostomy represents a promising alternative to surgical gastrojejunostomy and duodenal stenting for the management of gastric outlet obstruction. The technique has evolved significantly, offering a less invasive and more effective treatment option.
|
[
{
"affiliation": "Surgery Centre, Hong Kong Sanatorium and Hospital, Hong Kong SAR, China.",
"collective": null,
"firstname": "Anthony Yuen Bun",
"initials": "AYB",
"lastname": "Teoh"
},
{
"affiliation": "Department of Surgery, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong SAR, China.",
"collective": null,
"firstname": "Shannon Melissa",
"initials": "SM",
"lastname": "Chan"
},
{
"affiliation": "Department of Surgery, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong SAR, China.",
"collective": null,
"firstname": "Hon Chi",
"initials": "HC",
"lastname": "Yip"
}
] |
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
| null |
39370536
34039779
20003966
16362479
15015607
23299137
2439057
26282674
26215646
32051906
28697151
30725254
36374127
38061378
28382326
34937098
12397289
26684601
29871029
6282674
36890050
38194987
35030302
35429360
36792784
31917168
33711188
29527559
38155826
28750837
34181825
33852900
35692924
32991868
34569611
34352256
|
Is endoscopic ultrasound-guided gastroenterostomy better than surgical gastrojejunostomy or duodenal stenting?
| null | null | null | null | null | null |
null | null |
10.2340/00015555-1901
| null |
[] |
2014-05-24
|
A possible association between use of snus (Swedish moist snuff) and hand eczema was studied. 27,466 individuals responded to questions regarding hand eczema, tobacco use and other life style factors in a Swedish Public Health Survey in 2006, response rate 58%. Of these persons, 12.2% reported daily snus use (men 22.0%, women 4.3%), 15.5% daily smoking (men 14.4%, women 16.5%). Of snus users 7.5 % reported hand eczema (men 6.5%, women 11.8%), of smokers 11.7% (men 8.6%, women 13.6%) and of non-tobacco-users 9.7% (men 7.9%, women 11.0%). In multivariate analysis hand eczema was significantly less common in snus users, in total prevalence proportion ratio (PPR) = 0.813, in men PPR = 0.820, but significantly more common in smoking women, PPR = 1.238. Physical exercise was a confounder; gender an effect modifier. No positive association was demonstrated between snus use and hand eczema in contrast to the positive association found between smoking and hand eczema in women.
|
[
{
"affiliation": "Unit of Occupational and Environmental Dermatology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.",
"collective": null,
"firstname": "Karin",
"initials": "K",
"lastname": "Wrangsjö"
},
{
"affiliation": null,
"collective": null,
"firstname": "Magnus",
"initials": "M",
"lastname": "Alderling"
},
{
"affiliation": null,
"collective": null,
"firstname": "Gunborg",
"initials": "G",
"lastname": "Lindahl"
},
{
"affiliation": null,
"collective": null,
"firstname": "Birgitta",
"initials": "B",
"lastname": "Meding"
}
] |
Acta dermato-venereologica
| null |
24854399
|
Hand eczema and use of snus (moist snuff) - a population-based study.
| null | null | null | null | null | null |
null | null |
10.1518/001872008X288321
|
Statistically significant differences were found between chairs relative to head and hand motions. Also, significant differences were noted for the chairs' ability to move with the body during spinal articulation and the ability to provide support. Subjective assessments also yielded differences.
|
[] |
2008-09-05
|
The authors sought to use biomechanical measures, including motion and pressure, to compare four office chairs.
The fit of a person to a chair is related to the geometric and kinematic compatibility between the two. This geometric compatibility influences the motions that are allowed or prohibited and the support pressures at the body-chair interface. Thus, during evaluation, it is necessary to treat the chair and user as a system.
Four dynamic test conditions were evaluated with 14 participants of varying anthropometries. Test conditions were selected to compare the ability to accommodate primary and secondary motions (recline and spinal articulation) of seated occupants. The ability of a chair to allow recline, yet maintain head and hand positions, was compared across chairs. Also, the ability of each chair to allow and support spinal articulation was evaluated. Motion data for the chair, head, thorax, pelvis, and extremities were collected along with chair back pressures. Upon completion of testing, subjective assessments were also conducted.
Statistically significant differences were found between chairs relative to head and hand motions. Also, significant differences were noted for the chairs' ability to move with the body during spinal articulation and the ability to provide support. Subjective assessments also yielded differences.
Biomechanical analyses using motions and pressures can be conducted on office chairs with significant differences detected in their performance.
Biomechanical assessments can be used to compare and contrast office chairs in terms that are relatable to fatigue reduction as well as operator performance.
|
[
{
"affiliation": "Biomechanical Design Research Laboratory, Mechanical Engineering Department, Michigan State University, East Lansing, MI 48824, USA. [email protected]",
"collective": null,
"firstname": "Tamara Reid",
"initials": "TR",
"lastname": "Bush"
},
{
"affiliation": null,
"collective": null,
"firstname": "Robert P",
"initials": "RP",
"lastname": "Hubbard"
}
] |
Human factors
|
Four dynamic test conditions were evaluated with 14 participants of varying anthropometries. Test conditions were selected to compare the ability to accommodate primary and secondary motions (recline and spinal articulation) of seated occupants. The ability of a chair to allow recline, yet maintain head and hand positions, was compared across chairs. Also, the ability of each chair to allow and support spinal articulation was evaluated. Motion data for the chair, head, thorax, pelvis, and extremities were collected along with chair back pressures. Upon completion of testing, subjective assessments were also conducted.
|
18767522
|
A comparison of four office chairs using biomechanical measures.
| null | null | null | null | null | null |
null |
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
|
10.1111/exd.12264
| null |
[
"IFN-γ",
"T cell",
"adaptive immunity",
"alopecia areata",
"autoantigen",
"autoimmunity",
"cytokine",
"innate immunity",
"treatment",
"vitiligo"
] |
2013-10-18
|
Vitiligo and alopecia areata are common autoimmune diseases of the skin. Vitiligo is caused by the destruction of melanocytes and results in the appearance of white patches on any part of the body, while alopecia areata is characterized by patchy hair loss primarily on the scalp, but may also involve other areas as well. At first glance, the two diseases appear to be quite different, targeting different cell types and managed using different treatment approaches. However, the immune cell populations and cytokines that drive each disease are similar, they are closely associated within patients and their family members, and vitiligo and alopecia areata have common genetic risk factors, suggesting that they share a similar pathogenesis. Like apples and oranges, vitiligo and alopecia areata have some obvious differences, but similarities abound. Recognizing both similarities and differences will promote research into the pathogenesis of each disease, as well as the development of new treatments.
|
[
{
"affiliation": "Department of Medicine, Division of Dermatology, University of Massachusetts Medical School, Worcester, MA, USA.",
"collective": null,
"firstname": "John E",
"initials": "JE",
"lastname": "Harris"
}
] |
Experimental dermatology
| null |
24131336
11124178
19129529
22512484
22215015
22811720
19341938
21962830
19577331
21689244
10950121
15872205
18725574
19415997
22860695
23700152
12746478
17671634
19242513
23096715
22297636
15654992
12190862
18039949
21198791
21541348
22342018
21625016
15243524
16911396
22151832
22121261
15217364
22453596
23377387
15928633
20586836
21962188
21993561
20596022
22458952
8193398
21616562
21778811
10674368
22881476
10571834
20055821
21173923
21712899
8170863
23947678
20404233
20958268
20722389
23668538
23382179
17377159
18160967
15816839
23447019
23069909
22696056
21326294
18205713
23425123
23651466
22454627
18775308
22716243
12894993
|
Vitiligo and alopecia areata: apples and oranges?
| null | null | null | null | null | null |
null | null | null | null |
[] |
2001-02-07
|
Periprosthetic osteolysis is a major cause of aseptic loosening in artificial joint replacement. It is assumed to occur in conjunction with the activation of macrophages. We have shown in vitro that human osteoblast-like cells, isolated from bone specimens obtained from patients undergoing hip replacement, phagocytose fine particles of titanium alloy (TiAlV). The human osteoblast-like cells were identified immunocytochemically by the presence of bone-specific alkaline phosphatase (BAP). With increasing duration of culture, a variable number of the osteoblastic cells became positive for the macrophage marker CD68, independent of the phagocytosis of particles, with a fine granular cytoplasmic staining which was coexpressed with BAP as revealed by immunodoublestaining. The metal particles were not toxic to the osteoblastic cells since even in culture for up to four weeks massively laden cells were vital and had a characteristic morphology. Cells of the human osteosarcoma cell line (HOS 58) were also able to phagocytose metal particles but had only a low expression of the CD68 antigen. Fluorescence-activated cell scanning confirmed our immunocytochemical results. Additionally, the cells were found to be negative for the major histocompatibility complex-II (MHC-II) which is a marker for macrophages and other antigen-presenting cells. Negative results of histochemical tests for tartrate-resistant acid phosphatase excluded the contamination by osteoclasts or macrophages in culture. Our observations suggest that the osteoblast can either change to a phagocytosing cell or that the phagocytosis is an underestimated property of the osteoblast. The detection of the CD68 antigen is insufficient to prove the monocytic lineage. In order to discriminate between macrophages and osteoblasts additional markers should be used. To our knowledge, this is the first demonstration of cells of an osteoblastic origin which have acquired a mixed phenotype of both osteoblasts and macrophages.
|
[
{
"affiliation": "Department of Orthopaedics, Georg-August-University, Goettingen, Germany.",
"collective": null,
"firstname": "D E",
"initials": "DE",
"lastname": "Heinemann"
},
{
"affiliation": null,
"collective": null,
"firstname": "C",
"initials": "C",
"lastname": "Lohmann"
},
{
"affiliation": null,
"collective": null,
"firstname": "H",
"initials": "H",
"lastname": "Siggelkow"
},
{
"affiliation": null,
"collective": null,
"firstname": "F",
"initials": "F",
"lastname": "Alves"
},
{
"affiliation": null,
"collective": null,
"firstname": "I",
"initials": "I",
"lastname": "Engel"
},
{
"affiliation": null,
"collective": null,
"firstname": "G",
"initials": "G",
"lastname": "Köster"
}
] |
The Journal of bone and joint surgery. British volume
| null |
10755442
|
Human osteoblast-like cells phagocytose metal particles and express the macrophage marker CD68 in vitro.
| null | null | null | null | null | null |
null | null | null | null |
[] |
1986-10-01
|
After recalling some notions of embryology, the authors review in the light of recent literature the main causes of prenatal acquired hypoacusias (of viral, bacterial, parasitic, endocrinologic, toxic or other origins) and of perinatal acquired hypoacusias (prematurity, neonatal hypoxia, obstetrical traumatism, nuclear icterus, toxicity and others) by following a systematic course (incidence, clinical signs in the mother and child, audiologic diagnosis, anatamopathology, physiopathology, prevention, and treatment).
|
[
{
"affiliation": "ENT Department, University of Louvain, Brussels, Belgium.",
"collective": null,
"firstname": "T A",
"initials": "TA",
"lastname": "Robillard"
},
{
"affiliation": null,
"collective": null,
"firstname": "M C",
"initials": "MC",
"lastname": "Gersdorff"
}
] |
The Journal of auditory research
| null |
3325493
|
Prevention of pre- and perinatal acquired hearing defects, Part I: Study of causes.
| null | null | null | null | null | null |
null | null |
10.1101/2024.12.03.24318323
| null |
[] |
2024-12-16
|
[
{
"affiliation": null,
"collective": null,
"firstname": "Gregory R",
"initials": "GR",
"lastname": "Madden"
},
{
"affiliation": null,
"collective": null,
"firstname": "Robert",
"initials": "R",
"lastname": "Preissner"
},
{
"affiliation": null,
"collective": null,
"firstname": "Saskia",
"initials": "S",
"lastname": "Preissner"
},
{
"affiliation": null,
"collective": null,
"firstname": "William A",
"initials": "WA",
"lastname": "Petri"
}
] |
medRxiv : the preprint server for health sciences
| null |
39677433
|
Anti-Interleukin-23 Treatment Linked to Improved
| null | null | null | null | null | null |
|
null | null |
10.1111/j.1463-5224.2007.00600.x
| null |
[] |
2008-01-15
|
The goals of canine cataract and lens instability surgery should be to ensure a small incision, minimal tissue trauma, shortened surgical time, maintenance of the anterior chamber, and restoration of emmetropia through the use of a stable intraocular lens specifically designed for the canine eye. While this is usually the case with routine phacoemulsification and in-the-bag intraocular lens implantation, it is often not the case with lens instability, lens luxation or large posterior capsular ruptures. In such cases the incisions are often larger, surgical time and tissue trauma are excessive, and the patient is often left aphakic. The goal of this paper is to present a modified ab externo technique designed to allow removal of the lens and placement of a ciliary sulcus sutured IOL through a small incision, with minimal trauma and shortened surgical time. Use of this technique may allow more canine patients to be emmetropic postoperatively. In addition, the ease of this procedure may encourage earlier removal of an unstable lens and decrease the risk of secondary glaucoma and retinal detachment that occur in association with lens luxation.
|
[
{
"affiliation": "Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA. [email protected]",
"collective": null,
"firstname": "D A",
"initials": "DA",
"lastname": "Wilkie"
},
{
"affiliation": null,
"collective": null,
"firstname": "A J",
"initials": "AJ",
"lastname": "Gemensky-Metzler"
},
{
"affiliation": null,
"collective": null,
"firstname": "S G",
"initials": "SG",
"lastname": "Stone"
},
{
"affiliation": null,
"collective": null,
"firstname": "C R",
"initials": "CR",
"lastname": "Basham"
},
{
"affiliation": null,
"collective": null,
"firstname": "K N",
"initials": "KN",
"lastname": "Norris"
}
] |
Veterinary ophthalmology
| null |
18190352
|
A modified ab externo approach for suture fixation of an intraocular lens implant in the dog.
| null | null | null | null | null | null |
null |
Copyright© 2019 by the China Journal of Orthopaedics and Traumatology Press.
|
10.3969/j.issn.1003-0034.2019.08.017
|
No incision infection occurred in all 90 patients, and all patients were followed up from 4 to 8 months with an average of 6 months without pulmonary embolism occurred. There was no statistical difference in itraoperative bleeding volume among three groups(F=0.299,
|
[
"Arthroplasty, replacement, knee",
"Blood loss, surgical",
"Posture",
"Tranexamic acid"
] |
2019-09-20
|
To explore clinical efficacy and safety of application of tranexamic acid for two times combined with postoperative hip and knee on flexion position for reducing blood loss during total knee arthroplasty.
From January 2015 to January 2018, 90 patients with knee osteoarthritis underwent unilateral total knee arthroplasty, including 33 males and 57 females, aged from 61 to 85 years old with an average of(72.3±6.9) years old. The patients were randomly divided into three groups according to random number table, 30 patients in each group. In group A, there were 11 males and 9 females, aged from 61 to 84 years old with an average of (71.60±6.04) years old, body mass index was (26.04±1.95) kg/m², hemoglobin was(128.57±5.98) g/L, treated by 7.5 mg/kg tranexamic acid was injected intravenously before upper tourniquet, and 7.5 mg/kg tranexamic acid after closure of incision and before loosening tourniquet, meanwhile combined with flexion position of hip for 30° to 45° and flexion position of knee for 60° for 70°. In group B, there were 10 males and 20 females aged from 61 to 85 years old with an average of (72.04±7.47) years, body mass index was (25.92±1.70) kg/m², hemoglobin was (127.58±4.37) g/L, treated by 15 mg/kg tranexamic acid injected intravenously before loosening tourniquet. In group C, there were 12 males and 18 females aged from 62 to 85 years old with an average of (73.23±7.36) years, body mass index was (26.07±1.49) kg/m², hemoglobin was (128.31±5.61) g/L, treated with the same amount of normal saline before loosening tourniquet. Intraoperative bleeding volume, postoperative drainage volume, recessive blood loss, total blood loss volume, blood transfusion cases, activated partial thromboplastin time(APTT), prothrombin time(PT), prothrombin international standardized ratio (PT-INR) and indexes of D-dimer(D-D) were compared among three groups, as well as postoperative deep venous thrombosis and pulmonary embolism were observed among three groups.
No incision infection occurred in all 90 patients, and all patients were followed up from 4 to 8 months with an average of 6 months without pulmonary embolism occurred. There was no statistical difference in itraoperative bleeding volume among three groups(F=0.299,
The method of using tranexamic acid before upper tourniquet, after closure of incision and before loosening tourniquet-combined with the flexion position of hip and knee could effectively reduce postoperative drainage volume, recessive bleeding, total blood loss and blood transfusion cases after total knee arthroplasty, while it does not increase risk of deep vein thrombosis and pulmonary embolism.
|
[
{
"affiliation": "Department of Orthopaedics, Dongyang Traditional Chinese Medicine Hospital, Dongyang 322100, Zhejiang, China.",
"collective": null,
"firstname": "Ding-Quan",
"initials": "DQ",
"lastname": "Pan"
},
{
"affiliation": "Department of Orthopaedics, Dongyang Traditional Chinese Medicine Hospital, Dongyang 322100, Zhejiang, China.",
"collective": null,
"firstname": "Ling-Li",
"initials": "LL",
"lastname": "Chen"
},
{
"affiliation": "Department of Orthopaedics, Dongyang Traditional Chinese Medicine Hospital, Dongyang 322100, Zhejiang, China.",
"collective": null,
"firstname": "Biao",
"initials": "B",
"lastname": "Sun"
},
{
"affiliation": "Department of Orthopaedics, Dongyang Traditional Chinese Medicine Hospital, Dongyang 322100, Zhejiang, China.",
"collective": null,
"firstname": "Zhe",
"initials": "Z",
"lastname": "Yu"
},
{
"affiliation": "Department of Orthopaedics, Dongyang Traditional Chinese Medicine Hospital, Dongyang 322100, Zhejiang, China.",
"collective": null,
"firstname": "Jian-Bin",
"initials": "JB",
"lastname": "Ge"
},
{
"affiliation": "Department of Orthopaedics, Dongyang Traditional Chinese Medicine Hospital, Dongyang 322100, Zhejiang, China; [email protected].",
"collective": null,
"firstname": "Mei-Fen",
"initials": "MF",
"lastname": "Miao"
}
] |
Zhongguo gu shang = China journal of orthopaedics and traumatology
| null |
31533391
|
[Effect of tranexamic acid combined flexion position of hip and knee on perioperative bleeding following unilateral total knee arthroplasty].
| null | null | null | null | null | null |
null | null |
10.2106/JBJS.L00413
| null |
[] |
2012-07-20
| null |
[
{
"affiliation": "Department of Orthopaedics and Sports Medicine, University of Washington, Harborview Medical Center, 325 Ninth Avenue, Box 359798, Seattle, WA 98104, USA. [email protected]",
"collective": null,
"firstname": "Stephen K",
"initials": "SK",
"lastname": "Benirschke"
},
{
"affiliation": null,
"collective": null,
"firstname": "Eric",
"initials": "E",
"lastname": "Meinberg"
},
{
"affiliation": null,
"collective": null,
"firstname": "Sarah A",
"initials": "SA",
"lastname": "Anderson"
},
{
"affiliation": null,
"collective": null,
"firstname": "Clifford B",
"initials": "CB",
"lastname": "Jones"
},
{
"affiliation": null,
"collective": null,
"firstname": "Peter A",
"initials": "PA",
"lastname": "Cole"
}
] |
The Journal of bone and joint surgery. American volume
| null |
22810405
|
Fractures and dislocations of the midfoot: Lisfranc and Chopart injuries.
| null | null | null | null | null | null |
Changes of microcirculation flow tissue perfusion parameters and blood lactic acid level changes are closely related to the prognosis of patients with septic shock, which is of great value in the evaluation of the prognosis of patients with septic shock.
|
Copyright © 2022 Xuebing Yang et al.
|
10.1155/2022/1192902
10.4103/wjtcm.wjtcm_17_20
10.1371/journal.pone.0243990
10.1371/journal.pone.0231555
10.1007/s10151-020-02346-y
10.2478/jccm-2020-0001
10.1097/md.0000000000024835
10.23750/abm.v92i2.11086
10.1097/cce.0000000000000408
10.1097/pcc.0000000000002420
10.3390/ijerph18020824
10.1007/s40121-021-00563-y
10.1513/AnnalsATS.201907-562CC
|
Pcv-aCO2 and lactic acid in the death group were higher than those in the survival group on the 1st, 3rd, and 7th day of ICU stay (
|
[] |
2022-10-25
|
Septic shock is a common clinical critical disease with high mortality, hemodynamic instability, and easy to be complicated with multiple organ failure. The rapid progress of the patient's condition poses a serious threat to patient's safety.
To investigate the relationship between the dynamic monitoring of microcirculation perfusion parameters and blood lactic acid level and the prognosis of patients with infection shock in ICU.
A total of 104 patients with septic shock admitted to ICU of Affiliated Hai'an Hospital of Nantong University from February 2018 to June 2021 were selected for clinical research. According to the survival situation of patients after 28 days of treatment, they were divided into the death group (
Pcv-aCO2 and lactic acid in the death group were higher than those in the survival group on the 1st, 3rd, and 7th day of ICU stay (
Changes of microcirculation flow tissue perfusion parameters and blood lactic acid level changes are closely related to the prognosis of patients with septic shock, which is of great value in the evaluation of the prognosis of patients with septic shock.
|
[
{
"affiliation": "Department of Critical Care Medicine, Affiliated Hai'an Hospital of Nantong University, Hai'an County, Nantong, Jiangsu Province 226600, China.",
"collective": null,
"firstname": "Xuebing",
"initials": "X",
"lastname": "Yang"
},
{
"affiliation": "Department of Critical Care Medicine, Affiliated Hai'an Hospital of Nantong University, Hai'an County, Nantong, Jiangsu Province 226600, China.",
"collective": null,
"firstname": "Yaqing",
"initials": "Y",
"lastname": "Zhou"
},
{
"affiliation": "Department of Critical Care Medicine, Affiliated Hai'an Hospital of Nantong University, Hai'an County, Nantong, Jiangsu Province 226600, China.",
"collective": null,
"firstname": "Aiming",
"initials": "A",
"lastname": "Liu"
},
{
"affiliation": "Department of Critical Care Medicine, Affiliated Hai'an Hospital of Nantong University, Hai'an County, Nantong, Jiangsu Province 226600, China.",
"collective": null,
"firstname": "Zunguo",
"initials": "Z",
"lastname": "Pu"
}
] |
Contrast media & molecular imaging
| null |
36277595
32685244
33373376
34544182
32315321
33155148
32104731
33607851
33301518
32612839
33988146
33912838
34088948
32890098
31469984
35354493
35123576
33478004
34817839
32003610
|
Relationship between Dynamic Changes of Microcirculation Flow, Tissue Perfusion Parameters, and Lactate Level and Mortality of Septic Shock in ICU.
| null | null | null | null | null | null |
null | null |
10.3390/diagnostics13233546
10.3322/caac.21660
10.1016/j.cllc.2016.03.004
10.3322/caac.21811
10.1093/annonc/mdu089
10.2217/fon-2018-0527
10.1016/j.carj.2015.10.005
10.1016/j.jvir.2016.01.134
10.1097/MD.0000000000029016
10.1309/AJCPMY8UI7WSFSYY
10.3348/kjr.2020.0137
10.1148/radiol.2291020499
10.1259/bjr.20210065
10.1007/s11547-013-0360-1
10.1259/bjr.20190866
10.1007/s00330-016-4357-8
10.2214/AJR.08.2113
10.1148/radiology.216.1.r00jl3293
10.1007/s00270-019-02196-8
10.1186/s43055-022-00950-6
10.1016/j.crad.2022.05.019
10.1016/j.jvir.2021.06.022
10.1016/j.ejrad.2019.04.010
10.1148/radiol.2018181140
10.1007/s00330-015-3601-y
10.1007/s00330-008-0872-6
10.1016/j.crad.2015.06.081
10.1016/j.carj.2018.08.002
10.1111/1754-9485.13002
10.1016/j.jvir.2012.02.012
10.1148/radiol.2015141579
10.1148/radiol.2019182321
10.1148/radiol.11103506
10.1016/j.ejrad.2012.09.013
10.1097/RTI.0000000000000215
10.1016/S0003-4975(10)62816-0
10.5152/dir.2020.19202
10.1136/thorax.58.11.920
10.5152/dir.2014.14019
10.5334/jbsr.1591
| null |
[
"CT-guided lung biopsy",
"pneumothorax prevention",
"saline sealing"
] |
2023-12-09
|
This study aimed to assess the effectiveness of saline sealing in reducing the incidence of pneumothorax after a CT-guided lung biopsy. This was a retrospective case-control study of patients who underwent CT-guided biopsies for lung tumors using 18 G semiautomatic core needles in conjunction with 17 G coaxial needles. The patients were divided into two consecutive groups: a historical Group A (n = 111), who did not receive saline sealing, and Group B (n = 87), who received saline sealing. In Group B, NaCl 0.9% was injected through the coaxial needle upon its removal. The incidence of pneumothorax and chest tube insertion was compared between the two groups. Multivariate logistic regression was performed to verify the contribution of other pneumothorax risk factors. The study included 198 patients, with 111 in Group A and 87 in Group B. There was a significantly (
|
[
{
"affiliation": "Faculty of Medicine, \"Iuliu Hatieganu\" University of Medicine and Pharmacy, 400347 Cluj-Napoca, Romania.\nDepartment of Radiology, Oncology Institute \"Prof. Dr. Ion Chiricuta\", 400015 Cluj-Napoca, Romania.",
"collective": null,
"firstname": "Andrei",
"initials": "A",
"lastname": "Roman"
},
{
"affiliation": "Faculty of Medicine, \"Iuliu Hatieganu\" University of Medicine and Pharmacy, 400347 Cluj-Napoca, Romania.",
"collective": null,
"firstname": "Andreea",
"initials": "A",
"lastname": "Brozba"
},
{
"affiliation": "Faculty of Medicine, \"Iuliu Hatieganu\" University of Medicine and Pharmacy, 400347 Cluj-Napoca, Romania.",
"collective": null,
"firstname": "Alexandru",
"initials": "A",
"lastname": "Necula"
},
{
"affiliation": "Faculty of Medicine, \"Iuliu Hatieganu\" University of Medicine and Pharmacy, 400347 Cluj-Napoca, Romania.\nDepartment of Radiology, Cluj County Emergency Hospital, 400347 Cluj-Napoca, Romania.",
"collective": null,
"firstname": "Delia Doris",
"initials": "DD",
"lastname": "Muntean"
},
{
"affiliation": "Faculty of Medicine, \"Iuliu Hatieganu\" University of Medicine and Pharmacy, 400347 Cluj-Napoca, Romania.\nDepartment of Oncology, Oncology Institute \"Prof. Dr. Ion Chiricuta\", 400015 Cluj-Napoca, Romania.",
"collective": null,
"firstname": "Paul",
"initials": "P",
"lastname": "Kubelac"
},
{
"affiliation": "Faculty of Medicine, \"Iuliu Hatieganu\" University of Medicine and Pharmacy, 400347 Cluj-Napoca, Romania.\nDepartment of Radiotherapy, Oncology Institute \"Prof. Dr. Ion Chiricuta\", 400015 Cluj-Napoca, Romania.",
"collective": null,
"firstname": "Zsolt",
"initials": "Z",
"lastname": "Fekete"
},
{
"affiliation": "Faculty of Medicine, \"Iuliu Hatieganu\" University of Medicine and Pharmacy, 400347 Cluj-Napoca, Romania.\nDepartment of Hematology, Oncology Institute \"Prof. Dr. Ion Chiricuta\", 400015 Cluj-Napoca, Romania.",
"collective": null,
"firstname": "Ciprian",
"initials": "C",
"lastname": "Tomuleasa"
},
{
"affiliation": "Faculty of Medicine, \"Iuliu Hatieganu\" University of Medicine and Pharmacy, 400347 Cluj-Napoca, Romania.\nDepartment of Radiology, Cluj County Emergency Hospital, 400347 Cluj-Napoca, Romania.",
"collective": null,
"firstname": "Csaba",
"initials": "C",
"lastname": "Csutak"
},
{
"affiliation": "Faculty of Medicine, \"Iuliu Hatieganu\" University of Medicine and Pharmacy, 400347 Cluj-Napoca, Romania.\nDepartment of Radiology, Cluj County Emergency Hospital, 400347 Cluj-Napoca, Romania.",
"collective": null,
"firstname": "Diana",
"initials": "D",
"lastname": "Feier"
},
{
"affiliation": "Faculty of Medicine, \"Iuliu Hatieganu\" University of Medicine and Pharmacy, 400347 Cluj-Napoca, Romania.\nDepartment of Radiology, Cluj County Emergency Hospital, 400347 Cluj-Napoca, Romania.",
"collective": null,
"firstname": "Roxana",
"initials": "R",
"lastname": "Pintican"
},
{
"affiliation": "Faculty of Medicine, \"Iuliu Hatieganu\" University of Medicine and Pharmacy, 400347 Cluj-Napoca, Romania.\nDepartment of Surgery, Oncology Institute \"Prof. Dr. Ion Chiricuta\", 400015 Cluj-Napoca, Romania.",
"collective": null,
"firstname": "Catalin",
"initials": "C",
"lastname": "Vlad"
}
] |
Diagnostics (Basel, Switzerland)
| null |
38066786
33538338
27133540
37909877
24562446
30880466
27005931
27017121
35244081
25596245
33236542
14595149
34662206
24297594
31860329
27108299
19843735
10887232
30863965
35788268
34229043
31153555
30480487
25636421
18270713
26175218
30309700
32037715
22513394
25961632
31084480
22106349
23068560
27105052
3551860
32755876
14586042
25163758
30972378
|
Usefulness of Saline Sealing in Preventing Pneumothorax after CT-Guided Biopsies of the Lung.
| null | null | null | null | null | null |
null | null |
10.1523/JNEUROSCI.2710-13.2013
10.1002/gene.20010
10.1038/379257a0
10.1111/j.1529-8027.2009.00229.x
10.1167/iovs.09-5119
10.1038/nm.2750
10.1038/nature06191
10.1074/jbc.M807569200
10.1016/S0896-6273(00)81133-2
10.1093/brain/awr143
10.1016/0041-008X(87)90333-4
10.1093/brain/awn093
10.1038/nprot.2009.90
10.1186/1744-8069-7-92
10.1002/ana.22485
10.1073/pnas.1216080109
10.1536/ihj.52.146
10.1093/brain/aws187
10.1212/WNL.0b013e3182574f12
10.1038/nrneurol.2012.97
10.1111/j.1399-0004.2012.01937.x
10.1093/brain/awr349
10.1016/0022-2836(82)90515-0
10.1002/mus.10181
10.1097/01.wco.0000177330.35147.70
10.1073/pnas.95.23.13947
10.1016/0006-8993(87)90275-7
10.1016/j.neuropharm.2006.10.008
10.1002/ana.23725
10.1002/jmr.647
10.1126/science.8085162
10.1016/j.jtos.2012.01.002
10.1073/pnas.0602813103
10.1016/j.pain.2012.04.022
10.3949/ccjm.76a.08070
10.1016/j.brainres.2009.02.044
10.1161/CIRCRESAHA.112.274035
10.1074/jbc.M113.462366
10.1016/0022-510X(94)90239-9
10.1016/0079-6107(72)90005-3
10.1074/jbc.M110.132886
10.1016/S0896-6273(04)00116-3
| null |
[] |
2013-08-30
|
Idiopathic small-fiber neuropathy (I-SFN), clinically characterized by burning pain in distal extremities and autonomic dysfunction, is a disorder of small-caliber nerve fibers of unknown etiology with limited treatment options. Functional variants of voltage-gated sodium channel Nav1.7, encoded by SCN9A, have been identified in approximately one-third of I-SFN patients. These variants render dorsal root ganglion (DRG) neurons hyperexcitable. Sodium channel Nav1.8, encoded by SCN10A, is preferentially expressed in small-diameter DRG neurons, and produces most of the current underlying the upstroke of action potentials in these neurons. We previously demonstrated two functional variants of Nav1.8 that either enhance ramp current or shift activation in a hyperpolarizing direction, and render DRG neurons hyperexcitable, in I-SFN patients with no mutations of SCN9A. We have now evaluated additional I-SFN patients with no mutations in SCN9A, and report a novel I-SFN-related Nav1.8 mutation I1706V in a patient with painful I-SFN. Whole-cell voltage-clamp recordings in small DRG neurons demonstrate that the mutation hyperpolarizes activation and the response to slow ramp depolarizations. However, it decreases fractional channels resistant to fast inactivation and reduces persistent currents. Current-clamp studies reveal that mutant channels decrease current threshold and increase the firing frequency of evoked action potentials within small DRG neurons. These observations suggest that the effects of this mutation on activation and ramp current are dominant over the reduced persistent current, and show that these pro-excitatory gating changes confer hyperexcitability on peripheral sensory neurons, which may contribute to pain in this individual with I-SFN.
|
[
{
"affiliation": "Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, Connecticut 06510, USA.",
"collective": null,
"firstname": "Jianying",
"initials": "J",
"lastname": "Huang"
},
{
"affiliation": null,
"collective": null,
"firstname": "Yang",
"initials": "Y",
"lastname": "Yang"
},
{
"affiliation": null,
"collective": null,
"firstname": "Peng",
"initials": "P",
"lastname": "Zhao"
},
{
"affiliation": null,
"collective": null,
"firstname": "Monique M",
"initials": "MM",
"lastname": "Gerrits"
},
{
"affiliation": null,
"collective": null,
"firstname": "Janneke G J",
"initials": "JG",
"lastname": "Hoeijmakers"
},
{
"affiliation": null,
"collective": null,
"firstname": "Kim",
"initials": "K",
"lastname": "Bekelaar"
},
{
"affiliation": null,
"collective": null,
"firstname": "Ingemar S J",
"initials": "IS",
"lastname": "Merkies"
},
{
"affiliation": null,
"collective": null,
"firstname": "Catharina G",
"initials": "CG",
"lastname": "Faber"
},
{
"affiliation": null,
"collective": null,
"firstname": "Sulayman D",
"initials": "SD",
"lastname": "Dib-Hajj"
},
{
"affiliation": null,
"collective": null,
"firstname": "Stephen G",
"initials": "SG",
"lastname": "Waxman"
}
] |
The Journal of neuroscience : the official journal of the Society for Neuroscience
| null |
23986244
15048809
8538791
19909481
21632706
22581285
17914397
12451128
19233853
10798388
21705421
9133375
10594087
3629601
18524793
19617884
22136189
21698661
23115331
21646736
22826602
22539570
23304492
22641108
22803682
22286749
16991532
7108955
12210380
16155446
9811906
3620940
17140607
22810072
23280954
14872534
8085162
6255143
11495938
22330055
16702558
9405539
22703890
11259611
19414545
19269275
22723301
9382945
23536180
7964887
4566650
20926383
15046719
|
Small-fiber neuropathy Nav1.8 mutation shifts activation to hyperpolarized potentials and increases excitability of dorsal root ganglion neurons.
| null | null | null | null | null | null |
null | null | null |
PELD is an effective and safe treatment for lumbar disc herniation, lumbar spinal stenosis, recurrent lumbar disc herniation, and other lumbar diseases. Complications related to PELD include dural tear, nerve root injury, recurrence, and so on.
|
[] |
2020-02-06
|
Percutaneous endoscopic lumbar discectomy (PELD) often refers to percutaneous endoscopic transforaminal discectomy (PETD) and percutaneous endoscopic interlaminar discectomy (PEID). As a minimally invasive spinal procedure, PELD has gained increasing recognition for its small incision, quick recovery, short hospital stay, and equivalent clinical outcome compared to open surgery. In order to obtain satisfactory clinical efficacy, adequate consideration should be given regarding the indication of PELD. On the other hand, complications related to PELD will also significantly affect the safety and outcome of surgery.
Our objective was to conduct a literature review of the indications and complications of PELD and to provide our experience in patient selection and solutions to complications related to PELD.
The study is a literature review focused on the indications and complications of PELD.
The study is a literature review on the indications and complications of PELD.
A comprehensive review of available literature on PELD was performed. Particular focus was given to the development of indications and prevention of complications. The literature was searched in PubMed database, and key words were set as "percutaneous endoscopic lumbar discectomy", "percutaneous endoscopic transforaminal discectomy", "percutaneous endoscopic interlaminar discectomy", "PELD", "PETD", "PEID", "YESS" and "TESSYS".
PELD is an effective and safe treatment for lumbar disc herniation, lumbar spinal stenosis, recurrent lumbar disc herniation, and other lumbar diseases. Complications related to PELD include dural tear, nerve root injury, recurrence, and so on.
Some results drawn in this review are based on retrospective study or small sample size. Studies of larger sample size and more multicenter, randomized controlled trials should be conducted to evaluate the clinical efficacy and safety of PELD.
PELD is a promising surgical technique for lumbar diseases. Proper patient selection, excellent surgical skills, and rich experience are required for satisfactory outcomes.
Complications, indications, minimally invasive spine surgery, PELD.
|
[
{
"affiliation": "Department of Orthopaedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.",
"collective": null,
"firstname": "Mingming",
"initials": "M",
"lastname": "Pan"
},
{
"affiliation": "Department of Orthopaedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.",
"collective": null,
"firstname": "Qifan",
"initials": "Q",
"lastname": "Li"
},
{
"affiliation": "Department of Orthopaedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.",
"collective": null,
"firstname": "Sucheng",
"initials": "S",
"lastname": "Li"
},
{
"affiliation": "Department of Orthopaedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.",
"collective": null,
"firstname": "Haiqing",
"initials": "H",
"lastname": "Mao"
},
{
"affiliation": "Department of Orthopaedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.",
"collective": null,
"firstname": "Bin",
"initials": "B",
"lastname": "Meng"
},
{
"affiliation": "Department of Orthopaedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.",
"collective": null,
"firstname": "Feng",
"initials": "F",
"lastname": "Zhou"
},
{
"affiliation": "Department of Orthopaedic Surgery The First Affiliated Hospital of Soochow University.",
"collective": null,
"firstname": "Huilin",
"initials": "H",
"lastname": "Yang"
}
] |
Pain physician
| null |
32013278
|
Percutaneous Endoscopic Lumbar Discectomy: Indications and Complications.
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