mradermacher/MedSPO-3B-GGUF
3B
β’
Updated
β’
235
β’
1
Dataset Viewer (First 5GB)
conclusions
string | copyrights
string | doi
string | results
string | keywords
list | publication_date
string | abstract
string | authors
list | journal
string | methods
null | pubmed_id
string | title
string | isbn
null | publication_type
null | sections
null | publisher
null | publisher_location
null | language
null |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
null | null |
10.1249/JSR.0000000000000221
| null |
[] |
2016-01-09
| null |
[
{
"affiliation": "Department of Rehabilitation Medicine, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.",
"collective": null,
"firstname": "Jeehae",
"initials": "J",
"lastname": "Oh"
},
{
"affiliation": null,
"collective": null,
"firstname": "Hyun-Mi",
"initials": "HM",
"lastname": "Oh"
},
{
"affiliation": null,
"collective": null,
"firstname": "Jong In",
"initials": "JI",
"lastname": "Lee"
}
] |
Current sports medicine reports
| null |
26745169
|
Horseback Riding-Related Vertebral Compression Fracture from Walking in Women with Low Bone Mineral Density: Reports of Two Cases.
| null | null | null | null | null | null |
null |
Β© 2024 The Author(s). Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology.
|
10.1002/rcr2.70020
10.1056/NEJMoa2026834
10.1097/RHU.0000000000001905
10.1016/j.blre.2022.100971
10.1007/s11239-021-02608-y
10.1016/j.chest.2022.10.011
10.1111/bjd.20805
10.1002/art.41743
10.1007/s00296-022-05266-2
10.1111/ijd.16635
10.1001/jamaoto.2021.4092
10.1111/imj.15742
10.1016/j.jdcr.2022.02.022
10.1182/blood.2020010177
10.1038/s41409-022-01774-8
| null |
[
"VEXAS",
"interstitial lung disease",
"orbital cellulitis"
] |
2024-09-10
|
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) syndrome is a rare and recently identified disease resulting from a somatic mutation in the X-linked UBA1 gene in cells of myeloid lineage. It can present in a myriad of ways with the potential to affect various organ systems, including the lungs. VEXAS is usually steroid responsive, but no strong data exists for the use of a steroid-sparing agent. There is limited emerging evidence for haematopoietic stem cell transplantation in a select number of cases. Regardless, prognosis for this condition is poor and a treatment algorithm remains a priority. Herein, we present a case of VEXAS that came to attention with discovery of a relatively asymptomatic interstitial lung disease and led to recurrent febrile episodes with evolving multi-organ involvement.
|
[
{
"affiliation": "Department of Thoracic Medicine The Prince Charles Hospital Chermside Queensland Australia.",
"collective": null,
"firstname": "Sushil",
"initials": "S",
"lastname": "Agwan"
},
{
"affiliation": "Department of Thoracic Medicine The Prince Charles Hospital Chermside Queensland Australia.",
"collective": null,
"firstname": "Lai-Ying",
"initials": "LY",
"lastname": "Zhang"
},
{
"affiliation": "Department of Thoracic Medicine The Prince Charles Hospital Chermside Queensland Australia.",
"collective": null,
"firstname": "Thomas",
"initials": "T",
"lastname": "Baker"
},
{
"affiliation": "Faculty of Medicine The University of Queensland Herston Queensland Australia.\nDepartment of Clinical Immunology and Allergy Royal Brisbane and Women's Hospital Herston Queensland Australia.",
"collective": null,
"firstname": "Michael",
"initials": "M",
"lastname": "Lane"
},
{
"affiliation": "Anatomical Pathology The Prince Charles Hospital Chermside Queensland Australia.",
"collective": null,
"firstname": "David",
"initials": "D",
"lastname": "Godbolt"
},
{
"affiliation": "Department of Thoracic Medicine The Prince Charles Hospital Chermside Queensland Australia.\nFaculty of Medicine The University of Queensland Herston Queensland Australia.",
"collective": null,
"firstname": "John A",
"initials": "JA",
"lastname": "Mackintosh"
}
] |
Respirology case reports
| null |
39253323
33108101
36251488
35595613
34817788
36272567
34632574
33779074
36617363
36890121
35050349
35419965
35391910
33619558
35941354
|
A vexing case of a 73-year-old man with fevers, orbital cellulitis, and asymptomatic interstitial lung disease.
| null | null | null | null | null | null |
null | null |
10.1007/s12104-007-9077-1
| null |
[] |
2009-07-29
|
Resistance of cancer cells to oncotherapeutics designed to trigger programmed cell death (a.k.a. apoptosis) greatly limits clinical efficacy. The human FLN29 protein may play a role in this process via protein-protein interactions. Here we report the NMR spectral assignment of the N-terminal TRAF2/6-RING-zinc finger-like domain of this protein.
|
[
{
"affiliation": "Centre for Biologics Research, Biologics and Genetic Therapies Directorate, Health Canada, 251 Sir Frederick Banting Driveway, A/L 2201E, Tunney's Pasture, Ottawa, ON, Canada.",
"collective": null,
"firstname": "Simon",
"initials": "S",
"lastname": "SauvΓ©"
},
{
"affiliation": null,
"collective": null,
"firstname": "Geneviève",
"initials": "G",
"lastname": "Gingras"
},
{
"affiliation": null,
"collective": null,
"firstname": "RΓ©my A",
"initials": "RA",
"lastname": "Aubin"
},
{
"affiliation": null,
"collective": null,
"firstname": "Derek J",
"initials": "DJ",
"lastname": "Hodgson"
},
{
"affiliation": null,
"collective": null,
"firstname": "Yves",
"initials": "Y",
"lastname": "Aubin"
}
] |
Biomolecular NMR assignments
| null |
19636918
|
NMR assignment of the N-terminal TRAF-like RING zinc finger domain of human FLN29.
| null | null | null | null | null | null |
null | null | null | null |
[] |
1979-10-01
|
The bone mineral content of the upper ends of the tibia and the fibula was measured in 27 patients with tibia shaft fracture. The bone mineral decreased rapidly after fracture, the loss continuing for about 5 months. Later, towards the end of the first year after the injury, there was a slow restoration of mineral but no return to initial values in most instances. Although the average maximum loss was approximately 45%, only 25% of the initial bone mineral was missing after one year.
|
[
{
"affiliation": null,
"collective": null,
"firstname": "S M",
"initials": "SM",
"lastname": "Andersson"
},
{
"affiliation": null,
"collective": null,
"firstname": "B E",
"initials": "BE",
"lastname": "Nilsson"
}
] |
Clinical orthopaedics and related research
| null |
535229
|
Changes in bone mineral content following tibia shaft fractures.
| null | null | null | null | null | null |
Mutant KRAS monitoring in cfDNA using serial blood collection might reflect the disease status more accurately than invasive BM examinations, especially in patients with MM whose primary lesions have extra-BM locations. It could also help predict treatment responses and outcomes.
|
Copyright Β© 2023 Elsevier B.V. All rights reserved.
|
10.1016/j.cca.2023.117590
|
During treatment, the MAF was correlated with serum immunoglobulin A and free light chain-kappa levels. After the second autologous peripheral blood stem cell transplantation, the KRAS MAF became immediately positive after confirming MRD negativity using PCs from BM. Shortly thereafter, the patient experienced clinical relapse primarily involving bone lesions.
|
[
"Cell-free DNA",
"KRAS mutation",
"Liquid biopsy",
"Multiple myeloma"
] |
2023-10-15
|
Multiple myeloma (MM), a neoplasm of plasma cells (PCs), is a highly heterogeneous disease with multifocal dissemination throughout the body. Minimal residual disease (MRD) detected using PCs in bone marrow (BM) is important for MM management; however, frequent invasive examinations impose a significant burden on patients.
Analysis using plasma cell-free DNA (cfDNA) might represent an alternative tool for disease monitoring. In this study, we observed the disease status in a patient with MM by examining the KRAS mutation allele frequency (MAF) in plasma cfDNA using digital PCR.
During treatment, the MAF was correlated with serum immunoglobulin A and free light chain-kappa levels. After the second autologous peripheral blood stem cell transplantation, the KRAS MAF became immediately positive after confirming MRD negativity using PCs from BM. Shortly thereafter, the patient experienced clinical relapse primarily involving bone lesions.
Mutant KRAS monitoring in cfDNA using serial blood collection might reflect the disease status more accurately than invasive BM examinations, especially in patients with MM whose primary lesions have extra-BM locations. It could also help predict treatment responses and outcomes.
|
[
{
"affiliation": "Division of Metabolism and Biosystemic Science, Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa, Japan. Electronic address: [email protected].",
"collective": null,
"firstname": "Masayo",
"initials": "M",
"lastname": "Yamamoto"
},
{
"affiliation": "Division of Metabolism and Biosystemic Science, Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa, Japan.",
"collective": null,
"firstname": "Motohiro",
"initials": "M",
"lastname": "Shindo"
},
{
"affiliation": "Division of Metabolism and Biosystemic Science, Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa, Japan.",
"collective": null,
"firstname": "Takuya",
"initials": "T",
"lastname": "Funayama"
},
{
"affiliation": "Division of Metabolism and Biosystemic Science, Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa, Japan.",
"collective": null,
"firstname": "Chihiro",
"initials": "C",
"lastname": "Sumi"
},
{
"affiliation": "Division of Metabolism and Biosystemic Science, Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa, Japan.",
"collective": null,
"firstname": "Takeshi",
"initials": "T",
"lastname": "Saito"
},
{
"affiliation": "Division of Metabolism and Biosystemic Science, Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa, Japan.",
"collective": null,
"firstname": "Yasumichi",
"initials": "Y",
"lastname": "Toki"
},
{
"affiliation": "Division of Metabolism and Biosystemic Science, Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa, Japan.",
"collective": null,
"firstname": "Mayumi",
"initials": "M",
"lastname": "Hatayama"
},
{
"affiliation": "Institute of Biomedical Research, Sapporo Higashi Tokushukai Hospital, Sapporo, Japan.",
"collective": null,
"firstname": "Yusuke",
"initials": "Y",
"lastname": "Ono"
},
{
"affiliation": "Department of Hematology/Oncology, Asahikawa Kosei Hospital, Asahikawa, Japan.",
"collective": null,
"firstname": "Kazuya",
"initials": "K",
"lastname": "Sato"
},
{
"affiliation": "Division of Metabolism and Biosystemic Science, Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa, Japan; Institute of Biomedical Research, Sapporo Higashi Tokushukai Hospital, Sapporo, Japan.",
"collective": null,
"firstname": "Yusuke",
"initials": "Y",
"lastname": "Mizukami"
},
{
"affiliation": "Division of Metabolism and Biosystemic Science, Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa, Japan.",
"collective": null,
"firstname": "Toshikatsu",
"initials": "T",
"lastname": "Okumura"
}
] |
Clinica chimica acta; international journal of clinical chemistry
| null |
37837907
|
Monitoring mutant KRAS in plasma cell-free DNA can predict disease progression in a patient with multiple myeloma: A case report.
| null | null | null | null | null | null |
null |
Copyright Β© 2024 Wolters Kluwer Health, Inc. All rights reserved.
|
10.1097/RLU.0000000000005593
| null |
[] |
2025-01-08
|
A 70-year-old man experienced an epileptic seizure. Subsequent MRI performed on close examination revealed high signal in the left occipital cortex on fluid-attenuated inversion recovery. Gadolinium contrast indicated enhancement along the cortex. 11C-Methionine PET/CT scan, performed to differentiate from a brain tumor, showed high uptake mainly along the left occipital lobe cortex. Spinal fluid examination revealed Cryptococcus neoformans, leading to a diagnosis of Cryptococcus meningoencephalitis.
|
[
{
"affiliation": "From the Department of Radiology, Tokushima University Hospital, Tokushima, Japan.",
"collective": null,
"firstname": "Yoichi",
"initials": "Y",
"lastname": "Otomi"
},
{
"affiliation": "Department of Neurosurgery, Tokushima University Hospital, Tokushima, Japan.",
"collective": null,
"firstname": "Natsumi",
"initials": "N",
"lastname": "Teshima"
},
{
"affiliation": "Department of Community Medicine and Medical Science, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.",
"collective": null,
"firstname": "Takayoshi",
"initials": "T",
"lastname": "Shinya"
},
{
"affiliation": "From the Department of Radiology, Tokushima University Hospital, Tokushima, Japan.",
"collective": null,
"firstname": "Hideki",
"initials": "H",
"lastname": "Otsuka"
},
{
"affiliation": "From the Department of Radiology, Tokushima University Hospital, Tokushima, Japan.",
"collective": null,
"firstname": "Masafumi",
"initials": "M",
"lastname": "Harada"
}
] |
Clinical nuclear medicine
| null |
39774157
|
11C-Methionine PET/CT in Cryptococcus Meningoencephalitis.
| null | null | null | null | null | null |
null | null | null |
The clinical characteritics of ectopic molar pregnancy depend upon the site of the disease. It can be metastasized distantly in early stage. Digital subtraction angiography, colour ultrosound and laparotomy may play very important roles in the diagnosis of ectopic molar pregnancy. Regular chemotherapy and resection of drug-resistant focus are still the main methods of treatment.
|
[] |
2005-09-02
|
To summerize the experience in the diagnosis and treatment of ectopic molar pregnancy.
Clinical data of 3 cases of women with ectopic hydatidiform mole in Peking Union Medical College Hospital were analyzed retrospectively.
The clinical characteritics of ectopic molar pregnancy depend upon the site of the disease. It can be metastasized distantly in early stage. Digital subtraction angiography, colour ultrosound and laparotomy may play very important roles in the diagnosis of ectopic molar pregnancy. Regular chemotherapy and resection of drug-resistant focus are still the main methods of treatment.
Prophylactic chemotherapy for ectopic molar pregnancy should be emphasized. It is very important to make an early diagnosis of malignant metastasis and to give a regular treatment for the patients.
|
[
{
"affiliation": "Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.",
"collective": null,
"firstname": "S",
"initials": "S",
"lastname": "Ma"
},
{
"affiliation": null,
"collective": null,
"firstname": "Y",
"initials": "Y",
"lastname": "Xiang"
},
{
"affiliation": null,
"collective": null,
"firstname": "X",
"initials": "X",
"lastname": "Yang"
}
] |
Zhonghua fu chan ke za zhi
| null |
16134527
|
[Diagnosis and treatment of ectopic molar pregnancy].
| null | null | null | null | null | null |
null | null |
10.1080/15389588.2021.1980783
|
The literature shows that there is promising to strong evidence that alcohol monitoring is an effective component in treating DUI offenders and reducing recidivism rates. Alcohol ignition interlocks had the most studies (71 of the 131 articles identified in this review) and research shows that recidivism rates can be reduced by 50 to 90 percent for offenders while the interlock is installed. However, most ignition interlock studies are subject to sampling issues where participants are not randomly assigned to experimental and comparison groups. There is also evidence that alcohol monitoring is a key measure in 24/7 Sobriety Programs, in enforcing abstinence, and in overall alcohol treatment programs.
|
[
"Alcohol monitoring",
"driving-under-the-influence (DUI) offenders",
"literature review",
"transdermal alcohol concentration (TAC)"
] |
2021-10-22
|
The advent of continuous, passive, transdermal alcohol-monitoring devices and portable breath-testing devices with cameras provides a more efficient and reliable method for controlling the impaired driving of driving-under-the-influence (DUI) offenders. The objective of this study was to conduct a comprehensive literature review and synthesis of the strategies, the obstacles and the effectiveness of implementing alcohol monitoring as a component of treatment for DUI offenders.
A formalized review of the existing literature was conducted including both peer-reviewed and gray literature resources. Professional association websites were also searched in an effort to seek information on the effectiveness or ineffectiveness of alcohol monitoring as a strategy to treat DUI offenders. The review was guided by pre-defined inclusion/exclusion criteria that identified the scope and key terms to use when searching.
The literature shows that there is promising to strong evidence that alcohol monitoring is an effective component in treating DUI offenders and reducing recidivism rates. Alcohol ignition interlocks had the most studies (71 of the 131 articles identified in this review) and research shows that recidivism rates can be reduced by 50 to 90 percent for offenders while the interlock is installed. However, most ignition interlock studies are subject to sampling issues where participants are not randomly assigned to experimental and comparison groups. There is also evidence that alcohol monitoring is a key measure in 24/7 Sobriety Programs, in enforcing abstinence, and in overall alcohol treatment programs.
Transdermal monitoring is generally effective in deterring offenders from drinking alcohol. Offenders who drink or are otherwise noncompliant are likely to be identified. Transdermal monitoring helps enforce abstinence, which in turn helps offenders quit drinking and go into a recovery stage, potentially creating long-term safety benefits for the community. Continuous transdermal monitoring is a more effective means of monitoring drinking than other techniques and technologies (e.g., self-report, periodic or random breath tests, patches, or urinalysis).
|
[
{
"affiliation": "NORC at the University of Chicago, Bethesda, Maryland.",
"collective": null,
"firstname": "James C",
"initials": "JC",
"lastname": "Fell"
},
{
"affiliation": "NORC at the University of Chicago, Bethesda, Maryland.",
"collective": null,
"firstname": "Jennifer",
"initials": "J",
"lastname": "Scolese"
}
] |
Traffic injury prevention
| null |
34672885
|
The effectiveness of alcohol monitoring as a treatment for driving-while-intoxicated (DWI) offenders: A literature review and synthesis.
| null | null | null | null | null | null |
null |
Β© 2024 Wiley Periodicals LLC.
|
10.1002/pbc.31307
|
Participating caregivers were primarily Black or African American (88.9%), mothers (81.5%), publicly insured (55.6%), and single (51.9%). Caregivers described medical decision-making across acute symptom response, preventive disease management, and treatment initiation and/or discontinuation. Across these contexts of disease management, caregivers overarchingly prioritized protecting and improving their child's quality of life. Caregivers' medical decision-making processes were influenced by their SCA management experience, acquisition of SCA knowledge, and trust in medical providers. The extent to which these influences impacted caregivers' decision-making varied based on disease severity, disease management experience, and time since diagnosis.
|
[
"childhood",
"decisionβmaking",
"parents/caregiversβ perspectives",
"qualitative methods",
"sickle cell anemia/disease"
] |
2024-09-20
|
Sickle cell disease (SCD) is the most common genetic disorder among children. As the most common type of SCD, sickle cell anemia (SCA) is associated with severe complications across the lifespan. As parents/caregivers hold primary disease management responsibility during childhood, their involvement in disease management activities, including medical decision-making, is critical to successful and timely management of pediatric SCD. However, the processes through which caregivers make SCD-related decisions remain unknown. The current paper examined caregivers' decision-making processes and priorities when managing their child's SCD.
Parents and primary caregivers (NΒ =Β 27) of children with SCA (ages 0-12) completed individual semi-structured qualitative interviews exploring links between caregivers' decision-making and both daily and ongoing SCA management practices. Data were transcribed verbatim, cleaned, systematically coded, and analyzed using applied thematic analysis.
Participating caregivers were primarily Black or African American (88.9%), mothers (81.5%), publicly insured (55.6%), and single (51.9%). Caregivers described medical decision-making across acute symptom response, preventive disease management, and treatment initiation and/or discontinuation. Across these contexts of disease management, caregivers overarchingly prioritized protecting and improving their child's quality of life. Caregivers' medical decision-making processes were influenced by their SCA management experience, acquisition of SCA knowledge, and trust in medical providers. The extent to which these influences impacted caregivers' decision-making varied based on disease severity, disease management experience, and time since diagnosis.
Findings highlight how processes underlying caregivers' decision-making are directly influenced and informed by caregivers' lived experiences. Future work should develop provider-initiated collaborative interventions to support medical decision-making.
|
[
{
"affiliation": "Child and Family Health Lab, Department of Psychological and Brain Sciences, Boston University, Boston, Massachusetts, USA.",
"collective": null,
"firstname": "Ariel O",
"initials": "AO",
"lastname": "Blakey"
},
{
"affiliation": "Child and Family Health Lab, Department of Psychological and Brain Sciences, Boston University, Boston, Massachusetts, USA.\nNemours Children's Hospital, Delaware, Wilmington, Delaware, USA.",
"collective": null,
"firstname": "Christina M",
"initials": "CM",
"lastname": "Amaro"
},
{
"affiliation": "Child and Family Health Lab, Department of Psychological and Brain Sciences, Boston University, Boston, Massachusetts, USA.",
"collective": null,
"firstname": "Jenna Sandler",
"initials": "JS",
"lastname": "Eilenberg"
},
{
"affiliation": "Boston Medical Center, Boston, Massachusetts, USA.",
"collective": null,
"firstname": "Annelise",
"initials": "A",
"lastname": "Brochier"
},
{
"affiliation": "Boston Medical Center, Boston, Massachusetts, USA.\nDepartment of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.",
"collective": null,
"firstname": "Patricia L",
"initials": "PL",
"lastname": "Kavanagh"
},
{
"affiliation": "Child Health Equity Center, Department of Pediatrics, UMass Chan Medical School, UMass Memorial Children's Medical Center, Worcester, Massachusetts, USA.",
"collective": null,
"firstname": "Arvin",
"initials": "A",
"lastname": "Garg"
},
{
"affiliation": "Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.\nDepartment of Pediatrics, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.\nDepartment of Health Law, Policy & Management, Boston University School of Public Health, Boston, Massachusetts, USA.",
"collective": null,
"firstname": "Mari-Lynn",
"initials": "ML",
"lastname": "Drainoni"
},
{
"affiliation": "Child and Family Health Lab, Department of Psychological and Brain Sciences, Boston University, Boston, Massachusetts, USA.",
"collective": null,
"firstname": "Kristin",
"initials": "K",
"lastname": "Long"
}
] |
Pediatric blood & cancer
| null |
39302737
|
Characterizing medical decision-making in sickle cell disease during childhood: Qualitative perspectives of caregivers.
| null | null | null | null | null | null |
null | null | null | null |
[] |
2008-12-09
|
Southeast Asia is a region where the number of people infected with HIV/AIDS is one of the fastest growing in the world. Tuberculosis (TB) has grown along with the HIV epidemic. TB is not only the most common AIDS-defining illness but is also the leading cause of morbidity and mortality in AIDS patients. Cryptococcosis (meningitis or disseminated) is one of the most common opportunistic infections in AIDS patients. Cryptococcal meningitis is the first in the differential diagnosis considered with meningeal irritation. Penicillosis, a unique systemic mycosis, is an important emerging public health problem and has been classified as an AIDS defining illness in endemic areas like Thailand. Pneumocystis carinii (jiroveci) pneumonia has been one of the most important opportunistic infections in AIDS patients. Among parasitic infections, cryptosporidiosis is the most common intestinal protozoan infection relating to diarrhea in AIDS patients and toxoplasmosis is the only parasitic infection of the nervous system with a substantial incidence, up to 14.8%. Cytomegalovirus (CMV) retinitis has a lower prevalence compared to other opportunistic infections. In the era of highly active antiretroviral therapy (HAART), the incidence of opportunistic infections has significantly reduced in the past few years. Subsequently, the phenomena of immune restoration inflammatory syndrome (IRIS) in AIDS patients has been reported in this region as a result of HAART.
|
[
{
"affiliation": "Department of Parasitology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. [email protected]",
"collective": null,
"firstname": "Veeranoot",
"initials": "V",
"lastname": "Nissapatorn"
}
] |
The Southeast Asian journal of tropical medicine and public health
| null |
19058599
|
Lessons learned about opportunistic infections in southeast Asia.
| null | null | null | null | null | null |
null | null |
10.1016/s0039-6109(16)41136-9
| null |
[] |
1977-02-01
|
Most bullets which enter the body usually exit or lodge within the soft tissues having traveled in a straight line. Management of such patients is usually a simple matter of repairing the injuries incurred during the passage of the bullet. Emphasis must be placed on the initial management of the patient and his life-threatening injuries. Secondly, localization of the bullet should be done. Lastly, determination as to whether the bullet should be removed should be based on the hazards of its staying in its present position versus the hazards of its attempted removal.
|
[
{
"affiliation": null,
"collective": null,
"firstname": "A M",
"initials": "AM",
"lastname": "Ledgerwood"
}
] |
The Surgical clinics of North America
| null |
324004
|
The wandering bullet.
| null | null | null | null | null | null |
null |
Β© 2024 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
|
10.1002/alz.14162
| null |
[
"Alzheimer's Disease Neuroimaging Initiative",
"Alzheimer's disease",
"amyloidβrelated imaging abnormalities monitoring",
"clinical neuroimaging",
"magnetic resonance imaging protocols",
"neuroimaging",
"patient screening"
] |
2024-08-08
|
Phase four of the Alzheimer's Disease Neuroimaging Initiative (ADNI4) magnetic resonance imaging (MRI) protocols aim to maintain longitudinal consistency across two decades of data acquisition, while adopting new technologies. Here we describe and justify the study's design and targeted biomarkers. The ADNI4 MRI protocol includes nine MRI sequences. Some sequences require the latest hardware and software system upgrades and are continuously rolled out as they become available at each site. The main sequence additions/changes in ADNI4 are: (1) compressed sensing (CS) T1-weighting, (2) pseudo-continuous arterial spin labeling (ASL) on all three vendors (GE, Siemens, Philips), (3) multiple-post-labeling-delay ASL, (4) 1 mm
|
[
{
"affiliation": "Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.",
"collective": null,
"firstname": "Arvin",
"initials": "A",
"lastname": "Arani"
},
{
"affiliation": "Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.",
"collective": null,
"firstname": "Bret",
"initials": "B",
"lastname": "Borowski"
},
{
"affiliation": "Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.",
"collective": null,
"firstname": "John",
"initials": "J",
"lastname": "Felmlee"
},
{
"affiliation": "Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.",
"collective": null,
"firstname": "Robert I",
"initials": "RI",
"lastname": "Reid"
},
{
"affiliation": "Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, University College London, London, UK.",
"collective": null,
"firstname": "David L",
"initials": "DL",
"lastname": "Thomas"
},
{
"affiliation": "Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.",
"collective": null,
"firstname": "Jeffrey L",
"initials": "JL",
"lastname": "Gunter"
},
{
"affiliation": "Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA.",
"collective": null,
"firstname": "Lara",
"initials": "L",
"lastname": "Stables"
},
{
"affiliation": "Department of Psychology, Center for Brain Science, Harvard University, Cambridge, Massachusetts, USA.",
"collective": null,
"firstname": "Randy L",
"initials": "RL",
"lastname": "Buckner"
},
{
"affiliation": "Department of Biomedical Engineering, University of California Davis, Davis, California, USA.",
"collective": null,
"firstname": "Youngkyoo",
"initials": "Y",
"lastname": "Jung"
},
{
"affiliation": "Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA.",
"collective": null,
"firstname": "Duygu",
"initials": "D",
"lastname": "Tosun"
},
{
"affiliation": "Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA.",
"collective": null,
"firstname": "Michael",
"initials": "M",
"lastname": "Weiner"
},
{
"affiliation": "Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.",
"collective": null,
"firstname": "Clifford R",
"initials": "CR",
"lastname": "Jack"
},
{
"affiliation": null,
"collective": null,
"firstname": null,
"initials": null,
"lastname": null
}
] |
Alzheimer's & dementia : the journal of the Alzheimer's Association
| null |
39115941
2374495
17969013
37201641
36449413
22818791
15334582
25044035
38247051
15906300
12111955
22484410
23587694
30837858
31075422
|
Design and validation of the ADNI MR protocol.
| null | null | null | null | null | null |
null | null |
10.53854/liim-3203-15
| null |
[
"Milanβs plague epidemic",
"Yersinia pestis",
"bubonic plague",
"hidden cases"
] |
2024-09-17
|
In the summer of 1630, Milan experienced the most devastating plague epidemic in its history. In this study, addressed to investigate the earliest phases of the epidemic in the autumn of 1629, a set of unpublished and only partially known primary sources produced by the city's Officium Sanitatis was consulted and compared for the first time. Including those of two foreigners who died in the Lazzaretto, it was possible to ascertain a total of 39 cases of plague occurred in Milan between 9 October 1629 and the first weeks of 1630, of which 29 (74.4%) ended in death. Seven deaths presumably occurred at home were not recorded in the Liber Mortuorum, in which at least three other deaths caused by plague were deliberately attributed to a different cause. In particular, the case of the Vicario di Provisione in charge, Alfonso Visconti, probably the first death from plague occurred in Milan that year, was deliberately concealed for political reasons. Nevertheless, the spread of the disease remained limited in autumn 1629 and it was probably stopped until the following spring more by climatic factors than by the interventions of public health officials.
|
[
{
"affiliation": "Department of Pharmacological and Biomolecular Sciences, University of Milan, Italy.\nRomeo and Enrica Invernizzi National Institute of Molecular Genetics (INGM), Milan, Italy.",
"collective": null,
"firstname": "Riccardo",
"initials": "R",
"lastname": "Nodari"
},
{
"affiliation": "Department of the Humanities, Section of Historical and Geographical Science, University of Pavia, Italy.",
"collective": null,
"firstname": "Luca",
"initials": "L",
"lastname": "Fois"
},
{
"affiliation": "Department of Biomedical and Clinical Sciences, University of Milan, Italy.",
"collective": null,
"firstname": "Ester",
"initials": "E",
"lastname": "Luconi"
},
{
"affiliation": "Department of Historical Studies, University of Milan, Italy.",
"collective": null,
"firstname": "Folco",
"initials": "F",
"lastname": "Vaglienti"
},
{
"affiliation": "Department of Biomedical and Clinical Sciences, Pediatric Clinical Research Center \"Romeo and Enrica Invernizzi\", University of Milan, Italy.",
"collective": null,
"firstname": "Francesco",
"initials": "F",
"lastname": "Comandatore"
},
{
"affiliation": "Department of Biomedical and Clinical Sciences, University of Milan, Italy.",
"collective": null,
"firstname": "Massimo",
"initials": "M",
"lastname": "Galli"
}
] |
Le infezioni in medicina
| null |
39282547
|
Unveiling Milan's hidden cases of plague occurred in autumn 1629, before the great 1630 epidemic.
| null | null | null | null | null | null |
null | null |
10.1097/00007611-199408000-00009
| null |
[] |
1994-08-01
|
We report a case of Haemophilus paraphrophilus causing primary liver abscesses after blunt nonpenetrating trauma. A 32-year-old previously healthy white man sustained a back injury 2 months prior to admission with fever, chills, and night sweats. A computed tomography (CT) scan-directed needle aspirate of several hypoechoic hepatic lesions grew H paraphrophilus. Recent blunt trauma to the lower back may have contributed to the localization of this infection to an area of contusion or hematoma within the liver, followed by an episode of bacteremia that seeded the injury.
|
[
{
"affiliation": "Department of Medicine, University of South Florida College of Medicine, Tampa.",
"collective": null,
"firstname": "D O",
"initials": "DO",
"lastname": "Haight"
},
{
"affiliation": null,
"collective": null,
"firstname": "J F",
"initials": "JF",
"lastname": "Toney"
},
{
"affiliation": null,
"collective": null,
"firstname": "J N",
"initials": "JN",
"lastname": "Greene"
},
{
"affiliation": null,
"collective": null,
"firstname": "R L",
"initials": "RL",
"lastname": "Sandin"
},
{
"affiliation": null,
"collective": null,
"firstname": "A L",
"initials": "AL",
"lastname": "Vincent"
}
] |
Southern medical journal
| null |
8052889
|
Liver abscess following blunt trauma: a case report and review of the literature.
| null | null | null | null | null | null |
Recently there have been some reports of endoscopic ampullectomy for small carcinoid tumors. However, this case suggests that attention should be paid to the possibility of lymph node metastases as well as that of regional infiltration of the tumor even for minute ampullary carcinoid tumors to provide the best chance for cure.
| null |
10.1186/1477-7819-7-9
10.1097/01.mcg.0000225651.00308.79
10.1111/j.1440-1746.2005.03744.x
10.1002/1097-0142(19940315)73:6<1580::AID-CNCR2820730608>3.0.CO;2-0
10.1007/s11605-007-0389-3
10.1007/s11605-007-0240-x
10.1016/S1091-255X(03)00114-8
10.1002/1097-0142(19930201)71:3<686::AID-CNCR2820710306>3.0.CO;2-Z
| null |
[] |
2009-01-23
|
Carcinoid tumors are usually considered to have a low degree of malignancy and show slow progression. One of the factors indicating the malignancy of these tumors is their size, and small ampullary carcinoid tumors have been sometimes treated by endoscopic resection.
We report a case of a 63-year-old woman with a minute ampullary carcinoid tumor that was 7 mm in diameter, but was associated with 2 peripancreatic lymph node metastases. Mild elevation of liver enzymes was found at her regular medical check-up. Computed tomography (CT) revealed a markedly dilated common bile duct (CBD) and two enlarged peripancreatic lymph nodes. Endoscopy showed that the ampulla was slightly enlarged by a submucosal tumor. The biopsy specimen revealed tumor cells that showed monotonous proliferation suggestive of a carcinoid tumor. She underwent a pylorus-preserving whipple resection with lymph node dissection. The resected lesion was a small submucosal tumor (7 mm in diameter) at the ampulla, with metastasis to 2 peripancreatic lymph nodes, and it was diagnosed as a malignant carcinoid tumor.
Recently there have been some reports of endoscopic ampullectomy for small carcinoid tumors. However, this case suggests that attention should be paid to the possibility of lymph node metastases as well as that of regional infiltration of the tumor even for minute ampullary carcinoid tumors to provide the best chance for cure.
|
[
{
"affiliation": "Department of Gastroenterology and Hepatology, Shinko Hospital, Kobe, Hyogo, Japan. [email protected]",
"collective": null,
"firstname": "Eri",
"initials": "E",
"lastname": "Senda"
},
{
"affiliation": null,
"collective": null,
"firstname": "Koji",
"initials": "K",
"lastname": "Fujimoto"
},
{
"affiliation": null,
"collective": null,
"firstname": "Katsuhiro",
"initials": "K",
"lastname": "Ohnishi"
},
{
"affiliation": null,
"collective": null,
"firstname": "Akihiro",
"initials": "A",
"lastname": "Higashida"
},
{
"affiliation": null,
"collective": null,
"firstname": "Cho",
"initials": "C",
"lastname": "Ashida"
},
{
"affiliation": null,
"collective": null,
"firstname": "Toshio",
"initials": "T",
"lastname": "Okutani"
},
{
"affiliation": null,
"collective": null,
"firstname": "Shigeru",
"initials": "S",
"lastname": "Sakano"
},
{
"affiliation": null,
"collective": null,
"firstname": "Masayuki",
"initials": "M",
"lastname": "Yamamoto"
},
{
"affiliation": null,
"collective": null,
"firstname": "Rieko",
"initials": "R",
"lastname": "Ito"
},
{
"affiliation": null,
"collective": null,
"firstname": "Hajime",
"initials": "H",
"lastname": "Yamada"
}
] |
World journal of surgical oncology
| null |
19159493
15683115
17451212
17667049
15853978
10917194
8156484
17992565
17674113
13129555
8094317
|
Minute ampullary carcinoid tumor with lymph node metastases: a case report and review of literature.
| null | null | null | null | null | null |
null |
Copyright Β© 2020 Elsevier Inc. All rights reserved.
|
10.1016/j.fsc.2020.08.005
| null |
[
"Dorsal aesthetic lines",
"Hump resection",
"Internal nasal valve",
"Keystone area",
"Ligaments of the nose",
"Nasal dorsum",
"Preservation rhinoplasty",
"Upper lateral cartilage"
] |
2020-11-23
|
Preservation rhinoplasty may refer to preserving several anatomic components including: the nasal bones, upper lateral cartilages, the keystone area and/or ligaments of the nose. Preserving the osseocartilaginous framework or "dorsal preservation" minimizes or completely avoids violation of the dorsal aesthetic lines' architecture. Conventional hump reduction in open rhinoplasty disrupts these lines; however, it also provides versatility to reshape the entire dorsum. Surgical success with either technique requires a thorough understanding of the underlying nasal anatomy.
|
[
{
"affiliation": "Department of Otolaryngology-Head & Neck Surgery, Mansoura University, Faculty of Medicine, Gomhoreya Street, Mansoura 35516, Egypt. Electronic address: [email protected].",
"collective": null,
"firstname": "Mohamed",
"initials": "M",
"lastname": "Abdelwahab"
},
{
"affiliation": "Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.",
"collective": null,
"firstname": "Priyesh N",
"initials": "PN",
"lastname": "Patel"
}
] |
Facial plastic surgery clinics of North America
| null |
33220840
|
Conventional Resection Versus Preservation of the Nasal Dorsum and Ligaments: An Anatomic Perspective and Review of the Literature.
| null | null | null | null | null | null |
null |
Copyright Β© 2023 American Brachytherapy Society. All rights reserved.
|
10.1016/j.brachy.2023.04.006
|
In Phase 1, there was a significantly higher median pain score (p < 0.001) and more episodes with unacceptable pain scores (46%) in the IV-PCA group compared with either epidural modality (6-14%; p < 0.001). In Phase 2, we observed a greater median pain score (pβ―=β―0.007) and higher proportion of patient episodes with unacceptable pain scores (38%) in the CEI group compared with both the IV-PCA (13%) and PIEB-PCEA (14%) groups (pβ―=β―0.001). There was a significant difference in median OMED used throughout all phases across the PIEB-PCEA (0 mg), IV-PCA (70 mg), and CEI (15 mg) groups (p < 0.001).
|
[
"Cervical cancer",
"Epidural analgesia",
"Intrauterine brachytherapy",
"Operative analgesia"
] |
2023-07-10
|
Effective periprocedural analgesia is an important aspect of cervical brachytherapy delivery, with implications for patient comfort and attendance for subsequent fractions. We compared the efficacy and safety of three analgesic modalities: intravenous patient-controlled analgesia (IV-PCA), continuous epidural infusion (CEI) and programmed-intermittent epidural bolus with patient-controlled epidural analgesia (PIEB-PCEA).
Ninety-seven brachytherapy episodes involving 36 patients between July 2016 and June 2019 in a single tertiary center were retrospectively reviewed. Episodes were divided into two key phases: Phase 1 (while applicator remained in situ) and Phase 2 (following applicator removal until discharge or 4 h). For the primary endpoint, pain scores were retrieved and analyzed by analgesic modality with respect to median score and an internally defined "unacceptable" pain experience (>20% of scores being β₯4/10; i.e., moderate or greater). Total nonepidural oral morphine equivalent dose (OMED) and toxicity/complication events were reported as secondary endpoints.
In Phase 1, there was a significantly higher median pain score (p < 0.001) and more episodes with unacceptable pain scores (46%) in the IV-PCA group compared with either epidural modality (6-14%; p < 0.001). In Phase 2, we observed a greater median pain score (pβ―=β―0.007) and higher proportion of patient episodes with unacceptable pain scores (38%) in the CEI group compared with both the IV-PCA (13%) and PIEB-PCEA (14%) groups (pβ―=β―0.001). There was a significant difference in median OMED used throughout all phases across the PIEB-PCEA (0 mg), IV-PCA (70 mg), and CEI (15 mg) groups (p < 0.001).
PIEB-PCEA is safe and offers superior analgesia compared to IV-PCA or CEI for pain control after applicator placement in cervical brachytherapy.
|
[
{
"affiliation": "Department of Anaesthesia, Royal Hospital for Women, Randwick, NSW, Australia; Nepean Hospital, Kingswood, NSW, Australia.",
"collective": null,
"firstname": "Nicholas",
"initials": "N",
"lastname": "Chee"
},
{
"affiliation": "Department of Anaesthesia, Royal Hospital for Women, Randwick, NSW, Australia.",
"collective": null,
"firstname": "Alyson",
"initials": "A",
"lastname": "McGrath"
},
{
"affiliation": "Department of Radiation Oncology, Prince of Wales Hospital, Randwick, NSW, Australia; Prince of Wales Clinical School, Faculty of Medicine & Health, UNSW, Sydney, NSW, Australia.",
"collective": null,
"firstname": "Stephen R",
"initials": "SR",
"lastname": "Thompson"
},
{
"affiliation": "Department of Radiation Oncology, Prince of Wales Hospital, Randwick, NSW, Australia; St George and Sutherland Clinical School, Faculty of Medicine & Health, UNSW, Sydney, NSW, Australia.",
"collective": null,
"firstname": "Matthew C",
"initials": "MC",
"lastname": "Knox"
},
{
"affiliation": "Department of Anaesthesia, Royal Hospital for Women, Randwick, NSW, Australia.",
"collective": null,
"firstname": "Luca",
"initials": "L",
"lastname": "Marengo"
},
{
"affiliation": "Department of Radiation Oncology, Prince of Wales Hospital, Randwick, NSW, Australia; Prince of Wales Clinical School, Faculty of Medicine & Health, UNSW, Sydney, NSW, Australia.",
"collective": null,
"firstname": "Michael",
"initials": "M",
"lastname": "Jackson"
},
{
"affiliation": "Department of Anaesthesia, Royal Hospital for Women, Randwick, NSW, Australia.",
"collective": null,
"firstname": "John-Paul",
"initials": "JP",
"lastname": "Favero"
},
{
"affiliation": "Department of Anaesthesia, Royal Hospital for Women, Randwick, NSW, Australia. Electronic address: [email protected].",
"collective": null,
"firstname": "Leonie",
"initials": "L",
"lastname": "Watterson"
}
] |
Brachytherapy
| null |
37423807
|
Comparison of three analgesic regimens in women undergoing cervical brachytherapy.
| null | null | null | null | null | null |
null | null |
10.11152/mu-3209
|
The distribution of the Fallopian tubes corresponded to the positions of theΒ ipsilateral ovaries in the superoinferior direction (Ο2 =197.653, p<0.001), mediolateral direction (Ο2 =237.447, p <0.001) andΒ anteroposterior direction (Ο2 =109.746, p<0.001). Tubal morphology differed according to ovarian position in the superoinferiorΒ (Ο2 =21.804, p<0.001), mediolateral directions (Ο2 =4.679, p=0.031) but not in the anteroposterior direction (Ο2 =0.793,Β p=0.373).
|
[] |
2021-09-12
|
To investigate the positional relationship between the ovary and Fallopian tube and the relationship between theΒ ovarian position and tubal morphology.
A total of 195 patients with 338 fallopian tubes were enrolledΒ in this retrospective study. The ovarian and tubal positions were defined relative to the uterus in all directions. Tubal morphologyΒ was classified as smooth or tortuous.
The distribution of the Fallopian tubes corresponded to the positions of theΒ ipsilateral ovaries in the superoinferior direction (Ο2 =197.653, p<0.001), mediolateral direction (Ο2 =237.447, p <0.001) andΒ anteroposterior direction (Ο2 =109.746, p<0.001). Tubal morphology differed according to ovarian position in the superoinferiorΒ (Ο2 =21.804, p<0.001), mediolateral directions (Ο2 =4.679, p=0.031) but not in the anteroposterior direction (Ο2 =0.793,Β p=0.373).
Evaluating the ovarian position can provide preliminary information on the distribution and shapeof the Fallopian tube, helping the operator choose the appropriate initial plane and the necessary approaches for inspection.
|
[
{
"affiliation": "Department of Ultrasonography, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. [email protected].",
"collective": null,
"firstname": "Wu-Wu",
"initials": "WW",
"lastname": "Zheng"
},
{
"affiliation": "Department of Ultrasonography, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. [email protected].",
"collective": null,
"firstname": "Lixia",
"initials": "L",
"lastname": "Chen"
},
{
"affiliation": "Department of Ultrasonography, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. [email protected].",
"collective": null,
"firstname": "Shunping",
"initials": "S",
"lastname": "Chen"
},
{
"affiliation": "Department of Ultrasonography, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. [email protected].",
"collective": null,
"firstname": "Jian",
"initials": "J",
"lastname": "Zhu"
},
{
"affiliation": "Department of Gynecology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. [email protected].",
"collective": null,
"firstname": "Feng",
"initials": "F",
"lastname": "Lin"
},
{
"affiliation": "Department of Ultrasonography, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. [email protected].",
"collective": null,
"firstname": "Shihao",
"initials": "S",
"lastname": "Xu"
}
] |
Medical ultrasonography
| null |
34508616
|
Value of ovarian positional assessment on 4D hysterosalpingo-contrast sonography.
| null | null | null | null | null | null |
null |
Β© 2017 American Academy of Pain Medicine. All rights reserved. For permissions, please e-mail: [email protected].
|
10.1093/pm/pnw141
| null |
[
"Facet Joint",
"Fluoroscopy",
"Synovial Cyst",
"Zygoapophyseal Joint"
] |
2017-04-11
|
Synovial cysts of the lumbar zygapophysial joints can be treated by percutaneous injection of corticosteroids, with distension and rupture of the cyst. Some cysts can be difficult to access, particularly when they lie deep in relation to the lamina. This technical report describes a fluoroscopy-guided technique for accessing sublaminar pathology. Crucial to the safety of the technique is visualization of the ventral margin of the lamina using a contralateral oblique view, and controlling and limiting the insertion of the needle such that only its tip passes the lamina.
|
[
{
"affiliation": "Department of Rehabilitation Medicine, Mount Sinai Hospital, New York, NY, USA.",
"collective": null,
"firstname": "David",
"initials": "D",
"lastname": "Spinner"
},
{
"affiliation": "Department of Anesthesiology, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.",
"collective": null,
"firstname": "Moris",
"initials": "M",
"lastname": "Aner"
},
{
"affiliation": "Department of Rehabilitation Medicine, Mount Sinai Hospital, New York, NY, USA.",
"collective": null,
"firstname": "Geet",
"initials": "G",
"lastname": "Paul"
},
{
"affiliation": "Department of Anesthesiology, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.",
"collective": null,
"firstname": "Thomas",
"initials": "T",
"lastname": "Simopoulos"
},
{
"affiliation": "Department of Anesthesiology, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.",
"collective": null,
"firstname": "Jatinder",
"initials": "J",
"lastname": "Gill"
}
] |
Pain medicine (Malden, Mass.)
| null |
28395102
|
Percutaneous Translaminar Facet Cyst Rupture and Epidural Access-Description of a Novel Technique.
| null | null | null | null | null | null |
null | null |
10.1055/s-2008-1066086
| null |
[] |
1994-06-01
|
Of 450 children examined for front chest wall malformations, 210 underwent a corrective operation: 190 funnel chests and 20 pigeon chests. A classification of the anatomic forms is presented which contains 6 groups: vertical cup-shaped (the most common), horizontal cup-shaped, vallecular, mixed, complex with sternal torsion or polymalformations. The operation has been programmed in 64% of the cases between 10 and 18 years, but 36% were operated under 6 years because of a severe functional disturbance. On the technical side, Ravitch's procedure is still used on young infants; for the other cases sternochondro-plasty is to be preferred. The fixation of the chest wall is realized with an original, light, solid elastic material taking little space, and easy to remove. This material is presented. The immediate results: 62% very good, 35% good and 3% mediocre, sometimes do present a pejorative evolution, so that after two years of follow-up we notice: 55% remained perfect, 35% very good, 10% moderate of which, 4% to be reoperated. This deterioration touches more particularly the older children operated between 16 and 18 years. Among the children between 3 and 6 years the results are usually very good and remain stable with growth.
|
[
{
"affiliation": "Clinique Chirurgicale PΓ©diatrique, HΓ΄pital d'Enfants de Nancy, Vandoeuvre-Nancy, France.",
"collective": null,
"firstname": "J",
"initials": "J",
"lastname": "PrΓ©vot"
}
] |
European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie
| null |
8086387
|
Treatment of sternocostal wall malformations of the child. A series of 210 surgical corrections since 1975.
| null | null | null | null | null | null |
null | null |
10.1177/106689690100900108
| null |
[] |
2001-07-27
|
Five cases of renal cell carcinoma metastatic to the testis or its adnexa are described, including 3 that represented the initial presentation and mimicked primary testicular neoplasms. The patients ranged from 46 to 85 years of age. Three presented with self-identified testicular masses. One patient was investigated because of fever of unknown origin and was found to have a left rib metastasis. Further work-up led to the discovery of a testicular mass. The final patient had a tumor of the spermatic cord that was examined without knowledge that he had a prior renal neoplasm. All the tumors were unilateral. They ranged from 1.8 to 5.0 cm; multiple tumor nodules were present in one of them but the others were discrete solitary masses. Four tumors were yellow/yellow-tan, and one was gray. On microscopic examination all the tumors were of the clear cell type. Patterns included solid sheets, acini, cysts, alveoli, and trabeculae. Two had prominent vascular invasion. Diagnoses initially entertained in these cases included Sertoli cell tumor, Sertoli-Leydig cell tumor, and clear cell cystadenoma of the epididymis. In 3 cases a kidney tumor was discovered 2 to 4 weeks after the diagnosis of renal cell carcinoma metastatic to the testis was rendered. On follow-up two patients died of tumor, and two were alive (5 months and 1 year) after orchiectomy. The diagnosis of renal cell carcinoma metastatic to the testis should be considered in evaluating a clear cell tumor of the testis, particularly in an older male or if the appearance suggests a Sertoli cell tumor. The differences in survival between metastatic renal cell carcinoma and sex cord-stromal tumors indicate the importance of considering the former in the differential.
|
[
{
"affiliation": "Department of Pathology, Froedtert Memorial Lutheran Hospital and Medical College of Wisconsin, Milwaukee 53226-0509, USA.",
"collective": null,
"firstname": "M W",
"initials": "MW",
"lastname": "Datta"
},
{
"affiliation": null,
"collective": null,
"firstname": "T M",
"initials": "TM",
"lastname": "Ulbright"
},
{
"affiliation": null,
"collective": null,
"firstname": "R H",
"initials": "RH",
"lastname": "Young"
}
] |
International journal of surgical pathology
| null |
11469344
|
Renal cell carcinoma metastatic to the testis and its adnexa: a report of five cases including three that accounted for the initial clinical presentation.
| null | null | null | null | null | null |
null |
Copyright Β© 2016 American Society for Surgery of the Hand. Published by Elsevier Inc. All rights reserved.
|
10.1016/j.jhsa.2016.08.003
|
After an average of 26 months, M3 recovery of thumb and finger extension was observed in the 3 upper limbs from the 2 youngest patients who underwent a nerve transfer. None of the free gracilis-treated patients achieved scores above M2.
|
[
"Nerve transfer",
"free muscle transfer",
"spinal cord injury",
"tetraplegia"
] |
2016-09-07
|
With spinal cord injuries, muscles below the level of the lesion remain innervated despite the absence of volitional control. This persistent innervation protects against denervation atrophy and may allow for nerve transfers to treat long-standing lesions within the spinal cord. We tested the hypothesis that in chronic spinal cord lesions, muscles remained viable for reinnervation.
To test this hypothesis, we operated on 7 patients with tetraplegia to reconstruct thumb and finger extension after a mean interval of 5 years since injury. During surgery, if electrical stimulation of the posterior interosseous nerve (PIN) produced muscle contraction, the nerve to the supinator (NS) was transferred to the PIN. If no contractions were demonstrated, the muscles of the extensor compartment of the forearm were replaced via a free gracilis transfer with innervation supplied by the NS.
After an average of 26 months, M3 recovery of thumb and finger extension was observed in the 3 upper limbs from the 2 youngest patients who underwent a nerve transfer. None of the free gracilis-treated patients achieved scores above M2.
In our youngest patients aged 27 and 34 years, who were operated on 6 years after spinal cord injury, transfer of the NS to the PIN partially restored hand span.
Therapeutic V.
|
[
{
"affiliation": "Center of Biological and Health Sciences, Department of Neurosurgery, University of the South of Santa Catarina (Unisul), TubarΓ£o, Santa Catarina, Brazil; Department of Orthopedic Surgery, Governador Celso Ramos Hospital, FlorianΓ³polis, Santa Catarina, Brazil. Electronic address: [email protected].",
"collective": null,
"firstname": "Jayme Augusto",
"initials": "JA",
"lastname": "Bertelli"
},
{
"affiliation": "Center of Biological and Health Sciences, Department of Neurosurgery, University of the South of Santa Catarina (Unisul), TubarΓ£o, Santa Catarina, Brazil.",
"collective": null,
"firstname": "Marcos FlΓ‘vio",
"initials": "MF",
"lastname": "Ghizoni"
}
] |
The Journal of hand surgery
| null |
27593485
|
Nerve and Free Gracilis Muscle Transfers forΒ Thumb and Finger Extension Reconstruction in Long-standing Tetraplegia.
| null | null | null | null | null | null |
null |
Copyright: Β© 2023 Brain Circulation.
|
10.4103/bc.bc_64_22
| null |
[
"Carotid cavernous fistula",
"embolization",
"ophthalmoplegia"
] |
2023-05-08
|
Carotid cavernous fistulas (CCFs) are a rare but debilitating entity that may present with orbital or cerebral venous hypertension. CCFs may pose diagnostic and management pitfalls for clinicians as they can initially be misdiagnosed as primary orbital pathology or nonarteriovenous shunting-related cavernous sinus pathology. Furthermore, the resolution of pulsatile tinnitus could be an ominous sign in patients with untreated dural arteriovenous fistula. We describe a case of a 56-year-old male who presented with progressive right eye proptosis, congestion, decreased visual acuity, limited duction, exophthalmos, and pulsatile tinnitus. The patient had poor response to antibiotics and steroids. Magnetic resonance imaging brain showed significant inflammation involving the right orbit and atypical enhancement of the basal frontal lobe adjacent to the orbit. Cerebral angiography revealed an indirect right CCF and right sigmoid sinus thrombosis with stenosis of the right internal jugular vein. No clear predisposing factor was identified. Given the rapidly progressive nature of the condition, the patient successfully underwent endovascular treatment with transvenous approach to preserve flow in the internal carotid artery while ensuring occlusion of the fistula. A triad of proptosis, eye congestion, and signs of turbulent flow such as tinnitus or orbital bruit should raise suspicion for CCF. An interesting feature in this patient is that CCF may have occurred secondary to sigmoid sinus thrombosis with accompanying small cortical vein drainage. Our case highlights the importance of early recognition and timely intervention to ensure the resolution of orbital hypertension-related symptoms in rare cases of CCFs.
|
[
{
"affiliation": "Department of Neurology, University of Connecticut, Farmington, CT, USA.",
"collective": null,
"firstname": "Neeharika",
"initials": "N",
"lastname": "Krothapalli"
},
{
"affiliation": "Department of Interventional Neuroradiology, Hartford Hospital, Hartford, CT, USA.",
"collective": null,
"firstname": "Mohamad",
"initials": "M",
"lastname": "Fayad"
},
{
"affiliation": "Department of Neurosurgery, Hartford Hospital, Hartford, CT, USA.",
"collective": null,
"firstname": "Eric",
"initials": "E",
"lastname": "Sussman"
},
{
"affiliation": "Department of Interventional Neuroradiology, Hartford Hospital, Hartford, CT, USA.",
"collective": null,
"firstname": "Charles",
"initials": "C",
"lastname": "Bruno"
},
{
"affiliation": "Department of Interventional Neuroradiology, Hartford Hospital, Hartford, CT, USA.",
"collective": null,
"firstname": "Martin",
"initials": "M",
"lastname": "Ollenschleger"
},
{
"affiliation": "Department of Interventional Neuroradiology, Hartford Hospital, Hartford, CT, USA.",
"collective": null,
"firstname": "Tapan",
"initials": "T",
"lastname": "Mehta"
}
] |
Brain circulation
| null |
37151792
|
Carotid cavernous fistula: A rare but treatable cause of ophthalmoplegia - A case report.
| null | null | null | null | null | null |
Based on patient-specific dosimetry, the administered activity may be increased by an average factor of 2.4, indicating that most patients could be undertreated. The relative dosimetry approach based on planar imaging largely underestimates doses relative to reference values. Dosimetry based on planar bremsstrahlung imaging is not a dependable alternative to (111)In dosimetry.
| null |
10.1007/s00259-011-2040-5
|
The estimated red marrow absorbed doses from (111)In and (90)Y data were equivalent. In all cases, the doses absorbed by organs at risk were found to be within prescribed limits. The relative dosimetry approach applied to both the (90)Y and (111)In data significantly underestimated the doses relative to those obtained with the (111)In absolute dosimetry method which is generally accepted as the reference method (MIRD 16). In the case of (111)In, the relative dosimetry approach values were highly correlated (R(2) = 0.61) with the reference method values. Relative dosimetry estimates may be adjusted multiplying by a correction factor of 2.8. The (90)Y-ibritumomab tiuxetan relative dosimetry data correlated poorly with the reference method values (R (2) = 0.02).
|
[] |
2012-01-13
|
Radioimmunotherapy with (90)Y-ibritumomab tiuxetan has been used successfully used in the treatment of CD20-positive non-Hodgkin's lymphoma (NHL). Pretherapy imaging with (111)In-ibritumomab tiuxetan has been used in provisional dosimetry studies. Posttherapy imaging of (90)Y-ibritumomab tiuxetan for clinical use is appealing as it would simplify the data acquisition process and allow measurements of actual doses absorbed during treatment.
The study included 29 patients with non-Hodgkin's lymphoma, of whom 16 (group I) received a pretherapy (111)In-ibritumomab tiuxetan diagnostic study and (90)Y-ibritumomab tiuxetan treatment 1 week later, and 13 (group II) received only (90)Y-ibritumomab tiuxetan treatment. Planar imaging and blood sampling were performed in all patients. The doses absorbed by organs at risk were calculated using a whole-body average attenuation correction factor (relative dosimetry approach) and, in the case of the (111)In-ibritumomab tiuxetan image sets, also using organ-specific attenuation correction factors (absolute dosimetry method). Red marrow absorbed doses were based on gamma counting of blood samples.
The estimated red marrow absorbed doses from (111)In and (90)Y data were equivalent. In all cases, the doses absorbed by organs at risk were found to be within prescribed limits. The relative dosimetry approach applied to both the (90)Y and (111)In data significantly underestimated the doses relative to those obtained with the (111)In absolute dosimetry method which is generally accepted as the reference method (MIRD 16). In the case of (111)In, the relative dosimetry approach values were highly correlated (R(2) = 0.61) with the reference method values. Relative dosimetry estimates may be adjusted multiplying by a correction factor of 2.8. The (90)Y-ibritumomab tiuxetan relative dosimetry data correlated poorly with the reference method values (R (2) = 0.02).
Based on patient-specific dosimetry, the administered activity may be increased by an average factor of 2.4, indicating that most patients could be undertreated. The relative dosimetry approach based on planar imaging largely underestimates doses relative to reference values. Dosimetry based on planar bremsstrahlung imaging is not a dependable alternative to (111)In dosimetry.
|
[
{
"affiliation": "Nuclear Medicine Department, Istituto Nazionale per lo Studio e la Cura dei Tumori, Fondazione G Pascale, Napoli, Italy. [email protected]",
"collective": null,
"firstname": "C",
"initials": "C",
"lastname": "Arrichiello"
},
{
"affiliation": null,
"collective": null,
"firstname": "L",
"initials": "L",
"lastname": "Aloj"
},
{
"affiliation": null,
"collective": null,
"firstname": "M",
"initials": "M",
"lastname": "Mormile"
},
{
"affiliation": null,
"collective": null,
"firstname": "L",
"initials": "L",
"lastname": "D'Ambrosio"
},
{
"affiliation": null,
"collective": null,
"firstname": "F",
"initials": "F",
"lastname": "Frigeri"
},
{
"affiliation": null,
"collective": null,
"firstname": "C",
"initials": "C",
"lastname": "CaracΓ²"
},
{
"affiliation": null,
"collective": null,
"firstname": "M",
"initials": "M",
"lastname": "Arcamone"
},
{
"affiliation": null,
"collective": null,
"firstname": "F",
"initials": "F",
"lastname": "De Martinis"
},
{
"affiliation": null,
"collective": null,
"firstname": "A",
"initials": "A",
"lastname": "Pinto"
},
{
"affiliation": null,
"collective": null,
"firstname": "S",
"initials": "S",
"lastname": "Lastoria"
}
] |
European journal of nuclear medicine and molecular imaging
| null |
22237846
|
Feasibility of bremsstrahlung dosimetry for direct dose estimation in patients undergoing treatment with 90Y-ibritumomab tiuxetan.
| null | null | null | null | null | null |
null | null | null | null |
[] |
1980-12-01
|
1. Bovine kidney pyruvate dehydrogenase multienzyme complex is inactivated by elastase in a similar manner as described earlier for papain. The core component, lipoate acetyltransferase, is cleaved by elastase into an active fragment (Mr 26000) and a fragment with apparent Mr of 45000 as analyzed by dodecylsulfate gel electrophoresis. Due to the fragmentation of the core, the enzyme complex is disassembled into its component enzymes which retain their complete enzymatic activities as assayed separately. 2. A different mechanism was found for the inactivation of pyruvate dehydrogenase complex with trypsin and some other proteases (chymotrypsin, clostripain). In these cases, the pyruvate dehydrogenase component is inactivated rapidly by limited proteolysis. More slowly, the enzyme complex is disassembled simultaneously with fragmentation of the lipoate acetyltransferase which again results in an active fragment of Mr 26000 and another fragment of apparent Mr 45000. Upon prolonged proteolysis, the latter fragment is cleaved further to give products of Mr 36000 or lower. 3. The enzyme-bound lipoyl residues of the pyruvate dehydrogenase complex have been labelled covalently by incubation with [2-14C]pyruvate. After treatment of this [14C]acetyl-enzyme with papain, elastase, or trypsin, radioactivity was associated exclusively with the 45000-Mr and 36000-Mr fragments but not with the active 26000-Mr fragment. 4. It is concluded that the bovine kidney lipoate acetyltransferase core is composed of 60 subunits each consisting of two dissimilar folding domains. One of these contains the intersubunit binding sites as well as the active center for transacylation whereas the other possesses the enzyme-bound lipoyl residues.
|
[
{
"affiliation": null,
"collective": null,
"firstname": "G B",
"initials": "GB",
"lastname": "Kresze"
},
{
"affiliation": null,
"collective": null,
"firstname": "H",
"initials": "H",
"lastname": "Ronft"
}
] |
European journal of biochemistry
| null |
6780350
|
Bovine kidney pyruvate dehydrogenase complex. Limited proteolysis and molecular structure of the lipoate acetyltransferase component.
| null | null | null | null | null | null |
null |
Copyright Β© 2024 Noe Juvenal Mendoza-RamΓrez et al.
|
10.1155/2024/9313267
10.1038/s41586-020-2012-7
10.1016/j.chom.2020.02.001
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10.1038/s41556-021-00710-0
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10.1016/j.bbrc.2020.11.060
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10.1038/s41392-021-00575-7
10.1038/s41421-021-00306-w
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10.1007/s13238-021-00832-z
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10.1007/s00011-020-01413-2
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10.1007/s11427-020-1692-1
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10.3390/cells10030530
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10.1126/sciimmunol.abl9464
10.1038/s41590-020-0782-6
10.1038/s41467-023-42430-z
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10.1126/science.abc4730
10.3390/vaccines9111345
10.1016/j.ymthe.2022.02.016
| null |
[] |
2024-06-28
|
Vaccination is one of the most effective prophylactic public health interventions for the prevention of infectious diseases such as coronavirus disease (COVID-19). Considering the ongoing need for new COVID-19 vaccines, it is crucial to modify our approach and incorporate more conserved regions of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to effectively address emerging viral variants. The nucleocapsid protein is a structural protein of SARS-CoV-2 that is involved in replication and immune responses. Furthermore, this protein offers significant advantages owing to the minimal accumulation of mutations over time and the inclusion of key T-cell epitopes critical for SARS-CoV-2 immunity. A novel strategy that may be suitable for the new generation of vaccines against COVID-19 is to use a combination of antigens, including the spike and nucleocapsid proteins, to elicit robust humoral and potent cellular immune responses, along with long-lasting immunity. The strategic use of multiple antigens aims to enhance vaccine efficacy and broaden protection against viruses, including their variants. The immune response against the nucleocapsid protein from other coronavirus is long-lasting, and it can persist up to 11 years post-infection. Thus, the incorporation of nucleocapsids (N) into vaccine design adds an important dimension to vaccination efforts and holds promise for bolstering the ability to combat COVID-19 effectively. In this review, we summarize the preclinical studies that evaluated the use of the nucleocapsid protein as antigen. This study discusses the use of nucleocapsid alone and its combination with spike protein or other proteins of SARS-CoV-2.
|
[
{
"affiliation": "Departamento de Biomedicina Molecular CINVESTAV IPN, Av. IPN # 2508 Col, San Pedro Zacatenco, Mexico City 07360, Mexico.",
"collective": null,
"firstname": "Noe Juvenal",
"initials": "NJ",
"lastname": "Mendoza-RamΓrez"
},
{
"affiliation": "Departamento de Biomedicina Molecular CINVESTAV IPN, Av. IPN # 2508 Col, San Pedro Zacatenco, Mexico City 07360, Mexico.",
"collective": null,
"firstname": "Julio",
"initials": "J",
"lastname": "GarcΓa-Cordero"
},
{
"affiliation": "Laboratory of Malaria and Vector Research National Institute of Allergy and Infectious Diseases National Institutes of Health, Rockville, MD, USA.",
"collective": null,
"firstname": "Gaurav",
"initials": "G",
"lastname": "Shrivastava"
},
{
"affiliation": "Departamento de Biomedicina Molecular CINVESTAV IPN, Av. IPN # 2508 Col, San Pedro Zacatenco, Mexico City 07360, Mexico.",
"collective": null,
"firstname": "Leticia",
"initials": "L",
"lastname": "Cedillo-BarrΓ³n"
}
] |
Journal of immunology research
| null |
38939745
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|
The Key to Increase Immunogenicity of Next-Generation COVID-19 Vaccines Lies in the Inclusion of the SARS-CoV-2 Nucleocapsid Protein.
| null | null | null | null | null | null |
null |
Β©2023 by Radiation Research Society. All rights of reproduction in any form reserved.
|
10.1667/RADE-22-00208.1
10.1007/s12015-021-10177-z
| null |
[] |
2023-04-05
|
Survivors of acute radiation exposure suffer from the delayed effects of acute radiation exposure (DEARE), a chronic condition affecting multiple organs, including lung, kidney, heart, gastrointestinal tract, eyes, and brain, and often causing cancer. While effective medical countermeasures (MCM) for the hematopoietic-acute radiation syndrome (H-ARS) have been identified and approved by the FDA, development of MCM for DEARE has not yet been successful. We previously documented residual bone marrow damage (RBMD) and progressive renal and cardiovascular DEARE in murine survivors of H-ARS, and significant survival efficacy of 16,16-dimethyl prostaglandin E2 (dmPGE2) given as a radioprotectant or radiomitigator for H-ARS. We now describe additional DEARE (physiological and neural function, progressive fur graying, ocular inflammation, and malignancy) developing after sub-threshold doses in our H-ARS model, and detailed analysis of the effects of dmPGE2 administered before (PGE-pre) or after (PGE-post) lethal total-body irradiation (TBI) on these DEARE. Administration of PGE-pre normalized the twofold reduction of white blood cells (WBC) and lymphocytes seen in vehicle-treated survivors (Veh), and increased the number of bone marrow (BM) cells, splenocytes, thymocytes, and phenotypically defined hematopoietic progenitor cells (HPC) and hematopoietic stem cells (HSC) to levels equivalent to those in non-irradiated age-matched controls. PGE-pre significantly protected HPC colony formation ex vivo by >twofold, long term-HSC in vivo engraftment potential up to ninefold, and significantly blunted TBI-induced myeloid skewing. Secondary transplantation documented continued production of LT-HSC with normal lineage differentiation. PGE-pre reduced development of DEARE cardiovascular pathologies and renal damage; prevented coronary artery rarefication, blunted progressive loss of coronary artery endothelia, reduced inflammation and coronary early senescence, and blunted radiation-induced increase in blood urea nitrogen (BUN). Ocular monocytes were significantly lower in PGE-pre mice, as was TBI-induced fur graying. Increased body weight and decreased frailty in male mice, and reduced incidence of thymic lymphoma were documented in PGE-pre mice. In assays measuring behavioral and cognitive functions, PGE-pre reduced anxiety in females, significantly blunted shock flinch response, and increased exploratory behavior in males. No effect of TBI was observed on memory in any group. PGE-post, despite significantly increasing 30-day survival in H-ARS and WBC and hematopoietic recovery, was not effective in reducing TBI-induced RBMD or any other DEARE. In summary, dmPGE2 administered as an H-ARS MCM before lethal TBI significantly increased 30-day survival and ameliorated RBMD and multi-organ and cognitive/behavioral DEARE to at least 12 months after TBI, whereas given after TBI, dmPGE2 enhances survival from H-ARS but has little impact on RBMD or other DEARE.
|
[
{
"affiliation": "Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202.",
"collective": null,
"firstname": "Tong",
"initials": "T",
"lastname": "Wu"
},
{
"affiliation": "Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202.\nDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana 46202.",
"collective": null,
"firstname": "Louis M",
"initials": "LM",
"lastname": "Pelus"
},
{
"affiliation": "Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202.",
"collective": null,
"firstname": "P Artur",
"initials": "PA",
"lastname": "Plett"
},
{
"affiliation": "Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202.",
"collective": null,
"firstname": "Carol H",
"initials": "CH",
"lastname": "Sampson"
},
{
"affiliation": "Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202.",
"collective": null,
"firstname": "Hui Lin",
"initials": "HL",
"lastname": "Chua"
},
{
"affiliation": "Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202.",
"collective": null,
"firstname": "Alexa",
"initials": "A",
"lastname": "Fisher"
},
{
"affiliation": "Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202.",
"collective": null,
"firstname": "Hailin",
"initials": "H",
"lastname": "Feng"
},
{
"affiliation": "Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana 46202.",
"collective": null,
"firstname": "Liqiong",
"initials": "L",
"lastname": "Liu"
},
{
"affiliation": "Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana 46202.",
"collective": null,
"firstname": "Hongge",
"initials": "H",
"lastname": "Li"
},
{
"affiliation": "Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202.",
"collective": null,
"firstname": "Miguel",
"initials": "M",
"lastname": "Ortiz"
},
{
"affiliation": "Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202.",
"collective": null,
"firstname": "Supriya",
"initials": "S",
"lastname": "Chittajallu"
},
{
"affiliation": "Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana 46202.",
"collective": null,
"firstname": "Qianyi",
"initials": "Q",
"lastname": "Luo"
},
{
"affiliation": "Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana 46202.",
"collective": null,
"firstname": "Ashay D",
"initials": "AD",
"lastname": "Bhatwadekar"
},
{
"affiliation": "Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 46202.",
"collective": null,
"firstname": "Timothy B",
"initials": "TB",
"lastname": "Meyer"
},
{
"affiliation": "Department of Pharmacodynamics, University of Florida, Gainesville, Florida 32611.",
"collective": null,
"firstname": "Xin",
"initials": "X",
"lastname": "Zhang"
},
{
"affiliation": "Department of Pharmacodynamics, University of Florida, Gainesville, Florida 32611.",
"collective": null,
"firstname": "Daohong",
"initials": "D",
"lastname": "Zhou"
},
{
"affiliation": "Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 46202.",
"collective": null,
"firstname": "Kathryn D",
"initials": "KD",
"lastname": "Fischer"
},
{
"affiliation": "Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 46202.",
"collective": null,
"firstname": "David L",
"initials": "DL",
"lastname": "McKinzie"
},
{
"affiliation": "Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202.",
"collective": null,
"firstname": "Steven J",
"initials": "SJ",
"lastname": "Miller"
},
{
"affiliation": "Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202.",
"collective": null,
"firstname": "Christie M",
"initials": "CM",
"lastname": "Orschell"
}
] |
Radiation research
| null |
37014943
|
Further Characterization of Multi-Organ DEARE and Protection by 16,16 Dimethyl Prostaglandin E2 in a Mouse Model of the Hematopoietic Acute Radiation Syndrome.
| null | null | null | null | null | null |
null | null | null | null |
[] |
1968-07-15
| null |
[
{
"affiliation": null,
"collective": null,
"firstname": "P J",
"initials": "PJ",
"lastname": "Grosser"
}
] |
Zeitschrift fur arztliche Fortbildung
| null |
5728375
|
[Contribution to the epidemiology of quarrantine diseases].
| null | null | null | null | null | null |
null |
Β© 2025 The Author(s). Journal of Forensic Sciences published by Wiley Periodicals LLC on behalf of American Academy of Forensic Sciences.
|
10.1111/1556-4029.15702
10.1146/annurev.en.37.010192.001345
10.1520/JFS14778J
10.1007/s00414-016-1487-0
10.1093/aesa/51.3.261
10.1046/j.1365-2915.2001.00291.x
10.1093/jme/tjaa162
10.1146/annurev-ento-051710-103143
10.1093/jme/tjx119
10.1016/s0379-0738(01)00431-5
10.1093/jmedent/33.6.901
10.1016/j.forsciint.2014.09.023
10.1603/me12114
10.1111/j.1556-4029.2010.01539.x
10.1093/aesa/saw083
10.1093/ee/13.4.1083
10.3382/ps.0622371
10.1603/ME13161
10.4269/ajtmh.1999.61.500
10.3382/ps.2007-00301
10.1186/1471-2180-11-23
10.1007/s00436-007-0522-y
10.1016/j.forsciint.2018.02.004
10.4323/rjlm.2017.283
10.1093/jee/85.6.2291
10.1093/jee/48.6.654
10.1603/me09206
10.1016/j.jinsphys.2016.09.009
10.1016/s0379-0738(01)00413-3
10.1007/s00414-018-1922-5
10.1007/s00414-014-1014-0
10.1093/jme/tjx104
10.1603/EN12123
10.1603/0022-2585(2006)43[1023:codpia]2.0.co;2
10.1603/0022-2585-41.4.785
10.1890/ES14-00022.1
10.2307/1934999
10.1590/S0031-10492005002500001
10.1007/s00436-014-4002-x
10.1007/s00414-014-1029-6
10.1093/jmedent/34.3.353
10.1093/jme/tjaa058
10.1093/jme/tjaa046
10.1590/1809-4392201600773
10.1016/j.forsciint.2020.110333
10.3390/insects12040280
10.1007/s13253-017-0280-y
| null |
[
"Musca domestica",
"abuse and neglect",
"death investigation",
"forensic entomology",
"house fly",
"time of colonization (TOC)"
] |
2025-01-23
|
The house fly, Musca domestica, L. (Diptera: Muscidae), is a filth fly that is often associated with criminal and civil investigations surrounding abuse, neglect, and death of humans and other vertebrates. However, development data, which are crucial for determining the age of immatures collected under forensically relevant circumstances, are limited. Given the lack of data and the recognition of population-specific growth patterns, the aim of this study was to generate data for development of a M.βdomestica population from Texas, USA, on decomposing lean pork at 24.0Β°C (i.e., approximate room temperature in Texas) and 37.0Β°C (i.e., approximate human body temperature). As expected, fly development significantly differed between temperatures with development at the higher temperature taking significantly less time (development from egg to adult emergence occurred c. 48.5% faster at 37.0Β°C than at 24.0Β°C). The value of this dataset is demonstrated through an applied comparison with previously published data for the house fly. Differences in development times across life stages for the studies are evident, with shorter time of colonization estimations using the data published by Wang etΒ al. (2018), especially in later life stages. These data represent the first development dataset for the house fly on decomposing flesh in North America. Furthermore, the comparison with the previously published dataset demonstrate data from this study are of value for future forensic investigations in Texas or possibly other parts of the United States where this species is encountered, as they can be used to determine time of colonization.
|
[
{
"affiliation": "Department of Entomology, Texas A&M University, College Station, Texas, USA.",
"collective": null,
"firstname": "Casey A",
"initials": "CA",
"lastname": "Flint"
},
{
"affiliation": "Department of Entomology, Texas A&M University, College Station, Texas, USA.",
"collective": null,
"firstname": "Jennifer",
"initials": "J",
"lastname": "Rhinesmith-Carranza"
},
{
"affiliation": "Department of Entomology, Texas A&M University, College Station, Texas, USA.",
"collective": null,
"firstname": "Riley",
"initials": "R",
"lastname": "Bell"
},
{
"affiliation": "Department of Entomology, Texas A&M University, College Station, Texas, USA.",
"collective": null,
"firstname": "Jeffery K",
"initials": "JK",
"lastname": "Tomberlin"
}
] |
Journal of forensic sciences
| null |
39846129
1539937
10914578
27848012
11434551
32860043
20822449
28874020
11457615
8961637
25447170
23540111
20840295
6669503
24605454
10497998
18577626
21269466
17370089
19287365
2191797
29510361
20962738
1464690
20939391
27646733
11457606
30238161
24811885
28541462
23339798
17017243
15311476
25082014
24929639
9151502
32303768
32173734
32480285
33805865
|
Development of the house fly, Musca domestica L. (Diptera: Muscidae), on pork tissue at two temperatures.
| null | null | null | null | null | null |
null |
Copyright Β© 2025 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control. Published by Elsevier Ltd. All rights reserved.
|
10.1016/j.jiac.2025.102623
| null |
[
"Antimicrobial stewardship",
"Community pharmacist",
"Home visit",
"Japan",
"Leftover antibiotics"
] |
2025-01-13
|
This cross-sectional study investigated the prevalence and factors associated with leftover antibiotics in Japanese households through pharmacist home visits. The research, conducted in collaboration with pharmaceutical associations in Kyoto and Hirakata, included 37 cases analyzed from October 2023 to March 2024. Participants had a median age of 81 years and received a median of two antibiotic prescriptions in the past year. Leftover antibiotics were found in 18.9Β % of cases, with 5 out of 7 cases resulting from prophylactic prescriptions. Levofloxacin was the most common leftover antibiotic. Notably, 27.0Β % of participants reported a history of reusing leftover antibiotics. Logistic regression analysis revealed that frequent pharmacist visits (β₯2/month) were significantly associated with decreased leftover antibiotics (adjusted OR: 0.02, 95Β % CI: 0.00-0.48, pΒ =Β 0.015), whereas a history of antibiotic reuse increased the likelihood of leftovers (adjusted OR: 20.32, 95Β % CI: 1.78-231.33, pΒ =Β 0.015). Other factors, including the number of antibiotic prescriptions and the presence of medication support, did not show statistically significant associations. This study highlights the potential role of community pharmacists in promoting appropriate antibiotic use and managing leftover medications through home healthcare engagement. The findings suggest that regular pharmacist interventions could significantly improve medication management and contribute to antimicrobial stewardship efforts. Future research should replicate these findings in larger, more diverse populations to enhance generalizability and further explore the long-term impact of pharmacist interventions on antibiotic use patterns.
|
[
{
"affiliation": "Laboratory of Clinical Pharmacoepidemiology, Kyoto Pharmaceutical University, 5 Misasiana-cho, Yamashina-ku, Kyoto, 607-8414, Japan; Department of Pharmacy, Federation of National Public Service Personnel Mutual Aid Associations Hirakata Kohsai Hospital, 1-2-1, Fujisakahigashimachi, Hirakata-shi, Osaka, 573-0153, Japan. Electronic address: [email protected].",
"collective": null,
"firstname": "Keisuke",
"initials": "K",
"lastname": "Sawada"
},
{
"affiliation": "Laboratory of Clinical Pharmacoepidemiology, Kyoto Pharmaceutical University, 5 Misasiana-cho, Yamashina-ku, Kyoto, 607-8414, Japan. Electronic address: [email protected].",
"collective": null,
"firstname": "Yuichi",
"initials": "Y",
"lastname": "Muraki"
},
{
"affiliation": "Laboratory of Clinical Pharmacoepidemiology, Kyoto Pharmaceutical University, 5 Misasiana-cho, Yamashina-ku, Kyoto, 607-8414, Japan. Electronic address: [email protected].",
"collective": null,
"firstname": "Ryo",
"initials": "R",
"lastname": "Inose"
},
{
"affiliation": "Department of Pharmacy, Federation of National Public Service Personnel Mutual Aid Associations Hirakata Kohsai Hospital, 1-2-1, Fujisakahigashimachi, Hirakata-shi, Osaka, 573-0153, Japan. Electronic address: [email protected].",
"collective": null,
"firstname": "Shuji",
"initials": "S",
"lastname": "Kono"
},
{
"affiliation": "Department of Surgery, Federation of National Public Service Personnel Mutual Aid Associations Hirakata Kohsai Hospital, 1-2-1, Fujisakahigashimachi, Hirakata-shi, Osaka, 573-0153, Japan. Electronic address: [email protected].",
"collective": null,
"firstname": "Mitsuru",
"initials": "M",
"lastname": "Tanaka"
},
{
"affiliation": "Hirakata Pharmaceutical Association, 2-14-16, Kinya-hon-machi, Hirakata-shi, Osaka, 573-1197, Japan. Electronic address: [email protected].",
"collective": null,
"firstname": "Toshiaki",
"initials": "T",
"lastname": "Ueba"
},
{
"affiliation": "Kyoto Pharmaceutical Association, 563 Bairincho, Higashiyama-ku, Kyoto, 605-0863, Japan. Electronic address: [email protected].",
"collective": null,
"firstname": "Eiji",
"initials": "E",
"lastname": "Kawakami"
}
] |
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
| null |
39800317
|
Home visit survey on outpatient antibiotic use: Assessing leftover medications and factors influencing appropriate use by community Pharmacists.
| null | null | null | null | null | null |
null | null |
10.2214/ajr.153.5.1031
| null |
[] |
1989-11-01
| null |
[
{
"affiliation": "Department of Radiology, Babies Hospital, Columbia Presbyterian Medical Center, New York, NY 10032.",
"collective": null,
"firstname": "S J",
"initials": "SJ",
"lastname": "Abramson"
},
{
"affiliation": null,
"collective": null,
"firstname": "W E",
"initials": "WE",
"lastname": "Berdon"
},
{
"affiliation": null,
"collective": null,
"firstname": "R A",
"initials": "RA",
"lastname": "Kaufman"
},
{
"affiliation": null,
"collective": null,
"firstname": "C",
"initials": "C",
"lastname": "Ruzal-Shapiro"
}
] |
AJR. American journal of roentgenology
| null |
2801421
|
Hepatic parenchymal and subcapsular gas after hepatic laceration caused by blunt abdominal trauma.
| null | null | null | null | null | null |
null | null | null |
Patient had penile phymosis. Left scrotum had a normal testicle inside. Right scrotum was empty and hypoplastic. There was and ovoid formation near the root of the penis, similar to a testicle. Blood tests were normal. Orchydopexy was carried out following the technique by Bevan. Testicular biopsy was normal.
|
[] |
2004-09-24
|
To report the finding of a rare testicular anomaly.
We performed physical examination, blood tests, surgical exploration, and testicular biopsy.
Patient had penile phymosis. Left scrotum had a normal testicle inside. Right scrotum was empty and hypoplastic. There was and ovoid formation near the root of the penis, similar to a testicle. Blood tests were normal. Orchydopexy was carried out following the technique by Bevan. Testicular biopsy was normal.
Ectopic testicles usually keep the power of fertilization so that their treatment should not be as premature as in the case of cryptorchidism.
|
[
{
"affiliation": "ClΓnico QuirΓΊrgico Docente, Cmdte. Manuel Fajardo.",
"collective": null,
"firstname": "Francisco",
"initials": "F",
"lastname": "Alonso DomΓnguez"
},
{
"affiliation": null,
"collective": null,
"firstname": "Vicente",
"initials": "V",
"lastname": "Osorio Acosta"
}
] |
Archivos espanoles de urologia
| null |
15382574
|
[A rare case of testicular ectopia].
| null | null | null | null | null | null |
null | null | null |
(1) Before combining lung recruitment maneuver, 24 h after combining lung recruitment maneuver, and at the end of combining lung recruitment maneuver, the levels of PaO2 and OI of patients were respectively (77 Β± 8), (113 Β± 5), (142 Β± 6) mmHg, and (128 Β± 12), (188 Β± 8), (237 Β± 10) mmHg. As a whole, levels of PaO2 and OI changed significantly at different time points (with F values respectively 860. 96 and 842. 09, P values below 0. 01); levels of pH and PaCO2 showed no obvious changes (with F values respectively 0.35 and 3.13, P values above 0.05). (2) Levels of heart rate, MAP, CVP of all patients and CO of 4 patients who received PiCCO monitoring showed no significant changes at different time points (with F values from 0. 13 to 4. 26, P values above 0.05). Before combining lung recruitment maneuver, 24 h after combining lung recruitment maneuver, and at the end of combining lung recruitment maneuver, the EVLWI values of 4 patients who received PiCCO monitoring were respectively (13.5 Β± 1.3), (10.2 Β± 1.0), (7.0 Β± 0.8) mL/kg ( F =117.00, P <0.01). (3) The patients received mechanical ventilation at 2 to 72 h after burn, lasting for 14-32 (21 Β± 13) d. At post injury day 3-14 (7 Β± 5) d, lung recruitment maneuver was applied for 2-5 (3.0 Β± 2.0) d. All 15 patients recovered without other complications.
|
[] |
2014-11-29
|
To investigate the effects of lung protective ventilation strategy combined with lung recruitment maneuver on ARDS complicating patients with severe burn.
Clinical data of 15 severely burned patients with ARDS admitted to our burn ICU from September 2011 to September 2013 and conforming to the study criteria were analyzed. Right after the diagnosis of acute lung injury/ARDS, patients received mechanical ventilation with lung protective ventilation strategy. When the oxygenation index (OI) was below or equal to 200 mmHg (1 mmHg = 0. 133 kPa), lung recruitment maneuver was performed combining incremental positive end-expiratory pressure. When OI was above 200 mmHg, lung recruitment maneuver was stopped and ventilation with lung protective ventilation strategy was continued. When OI was above 300 mmHg, mechanical ventilation was stopped. Before combining lung recruitment maneuver, 24 h after combining lung recruitment maneuver, and at the end of combining lung recruitment maneuver, variables of blood gas analysis (pH, PaO2, and PaCO2) were obtained by blood gas analyzer, and the OI values were calculated; hemodynamic parameters including heart rate, mean arterial pressure (MAP), central venous pressure (CVP) of all patients and the cardiac output (CO), extravascular lung water index (EVLWI) of 4 patients who received pulse contour cardiac output (PiCCO) monitoring were monitored. Treatment measures and outcome of patients were recorded. Data were processed with analysis of variance of repeated measurement of a single group and LSD test.
(1) Before combining lung recruitment maneuver, 24 h after combining lung recruitment maneuver, and at the end of combining lung recruitment maneuver, the levels of PaO2 and OI of patients were respectively (77 Β± 8), (113 Β± 5), (142 Β± 6) mmHg, and (128 Β± 12), (188 Β± 8), (237 Β± 10) mmHg. As a whole, levels of PaO2 and OI changed significantly at different time points (with F values respectively 860. 96 and 842. 09, P values below 0. 01); levels of pH and PaCO2 showed no obvious changes (with F values respectively 0.35 and 3.13, P values above 0.05). (2) Levels of heart rate, MAP, CVP of all patients and CO of 4 patients who received PiCCO monitoring showed no significant changes at different time points (with F values from 0. 13 to 4. 26, P values above 0.05). Before combining lung recruitment maneuver, 24 h after combining lung recruitment maneuver, and at the end of combining lung recruitment maneuver, the EVLWI values of 4 patients who received PiCCO monitoring were respectively (13.5 Β± 1.3), (10.2 Β± 1.0), (7.0 Β± 0.8) mL/kg ( F =117.00, P <0.01). (3) The patients received mechanical ventilation at 2 to 72 h after burn, lasting for 14-32 (21 Β± 13) d. At post injury day 3-14 (7 Β± 5) d, lung recruitment maneuver was applied for 2-5 (3.0 Β± 2.0) d. All 15 patients recovered without other complications.
Lung protective ventilation strategy combining lung recruitment maneuver can significantly improve the oxygenation in patients with severe burn complicated with ARDS and may therefore improve the prognosis.
|
[
{
"affiliation": null,
"collective": null,
"firstname": "Xiaojian",
"initials": "X",
"lastname": "Li"
},
{
"affiliation": null,
"collective": null,
"firstname": "Xiaomin",
"initials": "X",
"lastname": "Zhong"
},
{
"affiliation": null,
"collective": null,
"firstname": "Zhongyuan",
"initials": "Z",
"lastname": "Deng"
},
{
"affiliation": null,
"collective": null,
"firstname": null,
"initials": null,
"lastname": "Zhang Xuhui"
},
{
"affiliation": null,
"collective": null,
"firstname": "Zhi",
"initials": "Z",
"lastname": "Zhang"
},
{
"affiliation": null,
"collective": null,
"firstname": "Tao",
"initials": "T",
"lastname": "Zhang"
},
{
"affiliation": null,
"collective": null,
"firstname": "Wenbin",
"initials": "W",
"lastname": "Tang"
},
{
"affiliation": null,
"collective": null,
"firstname": "Bib",
"initials": "B",
"lastname": "Chen"
},
{
"affiliation": null,
"collective": null,
"firstname": "Changling",
"initials": "C",
"lastname": "Liu"
},
{
"affiliation": null,
"collective": null,
"firstname": "Wenjuan",
"initials": "W",
"lastname": "Cao"
}
] |
Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns
| null |
25429808
|
[Effects of lung protective ventilation strategy combined with lung recruitment maneuver on patients with severe burn complicated with acute respiratory distress syndrome].
| null | null | null | null | null | null |
null | null |
10.1371/journal.pone.0258626
10.2298/AOO0502069S
10.1038/s41586-020-1969-6
10.1126/science.270.5235.467
10.1371/journal.pone.0188900
10.1038/nature12213
10.1038/ng.3658
10.1093/nar/gkz096
10.1186/s13059-016-0989-x
10.1002/jez.a.307
10.1093/nar/gkj109
10.1186/s12859-019-2634-7
10.1093/bioinformatics/btn182
10.1145/219717.219748
10.1007/978-3-540-76298-0_52
10.1145/2629489
10.1109/ACCESS.2019.2957812
10.1109/JBHI.2015.2392786
10.1109/TCBB.2015.2481399
10.1093/database/bat018
10.1093/bioinformatics/14.8.656
10.1093/nar/gkm1000
10.1093/nar/gki033
10.1186/1750-1172-5-S1-P1
10.1162/tacl_a_00051
10.1101/gr.1239303
10.1016/j.physa.2016.02.049
10.1063/1.5120818
| null |
[] |
2021-10-16
|
Understanding the role of genes in human disease is of high importance. However, identifying genes associated with human diseases requires laborious experiments that involve considerable effort and time. Therefore, a computational approach to predict candidate genes related to complex diseases including cancer has been extensively studied. In this study, we propose a convolutional neural network-based knowledge graph-embedding model (KGED), which is based on a biological knowledge graph with entity descriptions to infer relationships between biological entities. As an application demonstration, we generated gene-interaction networks for each cancer type using gene-gene relationships inferred by KGED. We then analyzed the constructed gene networks using network centrality measures, including betweenness, closeness, degree, and eigenvector centrality metrics, to rank the central genes of the network and identify highly correlated cancer genes. Furthermore, we evaluated our proposed approach for prostate, breast, and lung cancers by comparing the performance with that of existing approaches. The KGED model showed improved performance in predicting cancer-related genes using the inferred gene-gene interactions. Thus, we conclude that gene-gene interactions inferred by KGED can be helpful for future research, such as that aimed at future research on pathogenic mechanisms of human diseases, and contribute to the field of disease treatment discovery.
|
[
{
"affiliation": "School of Electrical Engineering and Computer Science, Gwangju Institute of Science and Technology, Buk-gu, Gwangju, Republic of Korea.",
"collective": null,
"firstname": "Wonjun",
"initials": "W",
"lastname": "Choi"
},
{
"affiliation": "School of Electrical Engineering and Computer Science, Gwangju Institute of Science and Technology, Buk-gu, Gwangju, Republic of Korea.",
"collective": null,
"firstname": "Hyunju",
"initials": "H",
"lastname": "Lee"
}
] |
PloS one
| null |
34653225
30207593
32025007
7569999
29244808
23770567
27618449
30773592
27333808
16902965
16381927
30736752
18586725
25616086
26415184
23584832
9789091
18045790
15360776
15608251
14597658
32237773
|
Identifying disease-gene associations using a convolutional neural network-based model by embedding a biological knowledge graph with entity descriptions.
| null | null | null | null | null | null |
null |
Β© 2024. The Author(s).
Β© 2024. The Author(s).
|
10.1186/s13293-024-00629-9
10.1126/science.1111726
10.1016/j.placenta.2005.12.006
10.1016/j.fertnstert.2017.03.012
10.1016/S1550-8579(07)80004-0
10.1371/journal.pone.0158807
10.1186/s13293-020-00299-3
10.1093/aje/kwm024
10.1111/j.1469-7580.2008.01039.x
10.1186/s13293-018-0165-y
10.1186/s13293-022-00470-y
10.1007/s43032-020-00355-8
10.1007/s13237-021-00367-y
10.1186/s13293-021-00381-4
10.1038/s41598-022-13544-z
10.1016/j.fertnstert.2022.11.010
10.1016/j.fertnstert.2018.11.005
10.1371/journal.pgen.0030236
10.1371/journal.pgen.0020190
10.1186/s13059-014-0550-8
10.1093/nar/gkv007
10.1111/j.2517-6161.1995.tb02031.x
10.1093/bioinformatics/btv560
10.1186/s12864-019-5761-7
10.21105/joss.00731
10.1186/1756-8935-8-6
10.1093/nar/gkab637
10.1210/clinem/dgaa503
10.1002/pd.4936
10.1186/gb-2010-11-10-r106
10.1080/15592294.2023.2179726
10.1186/s12915-023-01662-7
10.1186/s13148-022-01279-7
10.1016/j.placenta.2024.03.005
10.1186/s13148-016-0238-x
10.1093/hmg/ddz287
10.1371/journal.pone.0114768
10.32607/20758251-2014-6-2-71-83
10.1152/ajpheart.00958.2015
10.1038/srep14107
10.1016/j.preghy.2018.02.009
10.1111/1471-0528.14163
10.1186/s12884-020-03039-y
10.1080/14767058.2020.1818221
10.1016/j.wneu.2021.03.064
10.1002/cpbi.5
10.1073/pnas.2111256119
10.1016/j.gene.2023.147423
10.1080/15592294.2018.1429857
10.1007/s10495-012-0727-0
10.3389/fgene.2022.1014191
10.1002/dvdy.22755
10.1007/s43032-020-00364-7
10.1055/s-0037-1603570
10.1530/REP-09-0092
10.1016/j.placenta.2021.04.012
10.1080/15592294.2017.1342912
10.1371/journal.pone.0128918
10.1186/s13148-023-01432-w
10.1093/biolre/ioae007
|
Methylation analysis identified 151 differentially methylated probes (DMPs) significant at false discovery rateβ<β0.05, including 89 (59%) hypermethylated in females. Probe cg17612569 (GABPA, ATP5J) was the most significant CpG site, hypermethylated in males. There were 11 differentially methylated regions affected by fetal sex, with transcription factors ZNF300 and ZNF311 most significantly hypermethylated in males and females, respectively. RNA-sequencing identified 152 genes significantly sexually dimorphic at false discovery rateβ<β0.05. The 151 DMPs were associated with 18 genes with gene downregulation (Pβ<β0.05) in the direction of hypermethylation, including 2 genes significant at false discovery rateβ<β0.05 (ZNF300 and CUB and Sushi multiple domains 1, CSMD1). Both genes, as well as Family With Sequence Similarity 228 Member A (FAM228A), showed significant correlation between DNA methylation and sexually dimorphic gene expression, though FAM228A DNA methylation was less sexually dimorphic. Comparison with other sex differences studies found that cg17612569 is male-hypermethylated across gestation in placenta and in human blood up to adulthood.
|
[
"DNA methylation",
"Early pregnancy",
"Fetal sex",
"Healthy pregnancy",
"Placenta",
"Sexual dimorphism",
"Total RNA-seq"
] |
2024-08-17
|
Fetal sex and placental development impact pregnancy outcomes and fetal-maternal health, but the critical timepoint of placenta establishment in first trimester is understudied in human pregnancies.
Pregnant subjects were recruited in late first trimester (weeks 10-14) at time of chorionic villus sampling, a prenatal diagnostic test. Leftover placenta tissue was collected and stored until birth outcomes were known, then DNA and RNA were isolated from singleton, normal karyotype pregnancies resulting in live births. DNA methylation was measured with the Illumina Infinium MethylationEPIC BeadChip array (nβ=β56). Differential methylation analysis compared 25 females versus 31 males using a generalized linear model on 743,461 autosomal probes. Gene expression sex differences were analyzed with RNA-sequencing (nβ=β74). An integrated analysis was performed using linear regression to correlate gene expression and DNA methylation in 51 overlapping placentas.
Methylation analysis identified 151 differentially methylated probes (DMPs) significant at false discovery rateβ<β0.05, including 89 (59%) hypermethylated in females. Probe cg17612569 (GABPA, ATP5J) was the most significant CpG site, hypermethylated in males. There were 11 differentially methylated regions affected by fetal sex, with transcription factors ZNF300 and ZNF311 most significantly hypermethylated in males and females, respectively. RNA-sequencing identified 152 genes significantly sexually dimorphic at false discovery rateβ<β0.05. The 151 DMPs were associated with 18 genes with gene downregulation (Pβ<β0.05) in the direction of hypermethylation, including 2 genes significant at false discovery rateβ<β0.05 (ZNF300 and CUB and Sushi multiple domains 1, CSMD1). Both genes, as well as Family With Sequence Similarity 228 Member A (FAM228A), showed significant correlation between DNA methylation and sexually dimorphic gene expression, though FAM228A DNA methylation was less sexually dimorphic. Comparison with other sex differences studies found that cg17612569 is male-hypermethylated across gestation in placenta and in human blood up to adulthood.
Overall, sex dimorphic differential methylation with associated differential gene expression in the first trimester placenta is small, but there remain significant genes that may be regulated through methylation leading to differences in the first trimester placenta.
Fetal sex and placenta development affect pregnancy outcomes for both the fetus and mother throughout pregnancy, including risk of miscarriages, preterm birth, preeclampsia, and other outcomes. Epigenetics, the βoverlayβ of regulatory signals on DNA which affects how DNA is read, is not well understood in early pregnancy when critical placenta developments are happening that affect the rest of pregnancy. Here, we use leftover placenta biopsy samples (nβ=β56) donated by Cedars-Sinai patients with informed consent to learn about first trimester human placenta DNA methylation differences due to fetal sex. Out of the total 743,461 sites analyzed, we identified 151 sites significantly affected by fetal sex after correcting p-values to reduce false positives (false discovery rateβ<β0.05). We also performed an analysis to look at multiple sites and identified 11 regions across the genome with significant DNA methylation changes due to fetal sex. Furthermore, because DNA methylation is a regulatory mark on DNA which typically dampens gene expression, we also compared the DNA methylation sex differences to placental RNA-sequencing gene expression analysis using the same tissue from a mostly overlapping patient group (nβ=β74 total sequenced, nβ=β51 overlap). We identify 18 genes which show both significant DNA methylation differences and gene expression changes. The most significant gene was transcription factor ZNF300 with higher DNA methylation in males and reduced gene expression in males (and thus higher gene expression in females). This study identifies some sex differences that continue until later pregnancy and others that are unique to first trimester.
|
[
{
"affiliation": "Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, 8635 West 3rd Street, Suite 160, Los Angeles, CA, 90048, USA.",
"collective": null,
"firstname": "Tania L",
"initials": "TL",
"lastname": "Gonzalez"
},
{
"affiliation": "Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, 8635 West 3rd Street, Suite 160, Los Angeles, CA, 90048, USA.",
"collective": null,
"firstname": "Bryn E",
"initials": "BE",
"lastname": "Willson"
},
{
"affiliation": "Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, 8635 West 3rd Street, Suite 160, Los Angeles, CA, 90048, USA.\nDavid Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.",
"collective": null,
"firstname": "Erica T",
"initials": "ET",
"lastname": "Wang"
},
{
"affiliation": "The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.",
"collective": null,
"firstname": "Kent D",
"initials": "KD",
"lastname": "Taylor"
},
{
"affiliation": "Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, 8635 West 3rd Street, Suite 160, Los Angeles, CA, 90048, USA.",
"collective": null,
"firstname": "Allynson",
"initials": "A",
"lastname": "Novoa"
},
{
"affiliation": "Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, 8635 West 3rd Street, Suite 160, Los Angeles, CA, 90048, USA.",
"collective": null,
"firstname": "Akhila",
"initials": "A",
"lastname": "Swarna"
},
{
"affiliation": "Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, 8635 West 3rd Street, Suite 160, Los Angeles, CA, 90048, USA.",
"collective": null,
"firstname": "Juanita C",
"initials": "JC",
"lastname": "Ortiz"
},
{
"affiliation": "Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, 8635 West 3rd Street, Suite 160, Los Angeles, CA, 90048, USA.",
"collective": null,
"firstname": "Gianna J",
"initials": "GJ",
"lastname": "Zeno"
},
{
"affiliation": "Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.\nDivision of Rheumatology, Department of Medicine, Kao Autoimmune Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.",
"collective": null,
"firstname": "Caroline A",
"initials": "CA",
"lastname": "Jefferies"
},
{
"affiliation": "Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, 8635 West 3rd Street, Suite 160, Los Angeles, CA, 90048, USA.\nSamuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.",
"collective": null,
"firstname": "Kate",
"initials": "K",
"lastname": "Lawrenson"
},
{
"affiliation": "The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.",
"collective": null,
"firstname": "Jerome I",
"initials": "JI",
"lastname": "Rotter"
},
{
"affiliation": "The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.",
"collective": null,
"firstname": "Yii-Der Ida",
"initials": "YI",
"lastname": "Chen"
},
{
"affiliation": "Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, 8635 West 3rd Street, Suite 160, Los Angeles, CA, 90048, USA.\nDavid Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.",
"collective": null,
"firstname": "John",
"initials": "J",
"lastname": "Williams"
},
{
"affiliation": "Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.",
"collective": null,
"firstname": "Jinrui",
"initials": "J",
"lastname": "Cui"
},
{
"affiliation": "Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.",
"collective": null,
"firstname": "Mark O",
"initials": "MO",
"lastname": "Goodarzi"
},
{
"affiliation": "Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, 8635 West 3rd Street, Suite 160, Los Angeles, CA, 90048, USA. [email protected].\nDavid Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. [email protected].\nDepartment of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA. [email protected].",
"collective": null,
"firstname": "Margareta D",
"initials": "MD",
"lastname": "Pisarska"
}
] |
Biology of sex differences
| null |
39152463
|
Sexually dimorphic DNA methylation and gene expression patterns in human first trimester placenta.
| null | null | null | null | null | null |
null | null | null | null |
[] |
2021-10-13
|
Abdominal actinomycosis refers to a rare chronic suppurative infectious occurrence, caused by filamentous Gram-positive microaerophilic and anaerobic bacteria Actinomyces, that may appear as an abdominal mass and/or abscess, feasibly mimicking a malignancy 1,2. Due to its rarity and unspecific clinical evidence, the majority of cases are diagnosed after tissue specimen. We hereby report a case of a 69-year-old patient with a one week worsening abdominal pain and swelling. A large tender palpable mass in the epigastric region was noted on physical exam. An ultrasound-guided drainage followed by a surgical excision approach became both a way to confirm the diagnosis and a therapeutic tool. Diagnosis of actinomycosis was made on histopathology and microbiology. Even though the incidence of actinomycosis has decreased, the abdominal presentation has been observed with increasing frequency 3. KEY WORDS: Actinomycosis, Abdominal wall, Abdominal abscess, foreign-body reaction, Colonic neoplasms.
LβActinomicosi rappresenta un processo infiammatorio e granulomatoso cronico prodotto da un patogeno opportunista responsabile nel 20% dei casi di un severo processo infettivo addominale. Lβincidenza globale di casi registrati di actinomicosi risulta in diminuzione, mentre lβinteressamento pelvico ed addominale della patologia Γ¨ in aumento. Stadi avanzati del quadro cronico suppurativo che contraddistingue lβactinomicosi addominopelvica possono manifestarsi quali massa addominale con multiple cavitΓ ascessuali ed un severo quadro infettivo che puΓ² arrivare a coinvolgere la parete addominale con formazione di fistole o compromettere il perineo ed altri organi limitrofi. Date la raritΓ e lβaspecificitΓ nelle evidenze clinico-radiologiche di questa patologia, la gran parte dei casi viene identificata grazie allβanalisi istopatologica e microbiologica colturale. Nella nostra esperienza riportiamo il caso di un paziente di 69 anni affetto da dolore addominale ingravescente, associato allβobiettivitΓ clinica di massa palpabile epigastrica ed a quella radiologica di neoformazione contenente un presunto corpo estraneo e coinvolgente il colon trasverso. Il quadro clinico lasciava spazio ad un ampio spettro di diagnosi differenziali compreso il sospetto di malignitΓ . Lβaspirazione eco-guidata della massa ha rivelato lβeccezionale presenza in sede addominale di colonie di Actinomyces odontolyticus, noto commensale del cavo orale. Il paziente Γ¨ stato sottoposto ad asportazione en bloc della massa che, come confermato anche mediante endoscopia intraoperatoria, non presentava franchi aspetti invasivi verso gli organi limitrofi; la diagnosi Γ¨ stata ottenuta mediante analisi istologica e batteriologica. Pensiamo che il paziente, solito allβutilizzo quotidiano di filo interdentale, possa averne incidentalmente ingerito una minima parte che Γ¨ servita quale veicolo per la migrazione del batterio commensale orale sino alla sede colica. Lβinclusione sperimentale di frammenti plastici di filo interdentale ha rivelato importanti somiglianze con il materiale estraneo riscontrato nel campione istologico del paziente. Il trattamento chirurgico insieme con la somministrazione di alti dosaggi antibiotici hanno consentito la risoluzione del quadro clinico. Spesso i reperti clinico-radiologici di questa patologia fanno supporre una eziologia maligna, per cui lβanalisi istologica e microbiologica colturale divengono mandatorie per raggiungere una corretta diagnosi differenziale e definire il trattamento piΓΉ adeguato, soprattutto alla luce delle severe complicanze che altrimenti potrebbero derivarne. Una miglior consapevolezza della patologia deve incoraggiare il tasso di sospetto e possibilmente guidare verso una diagnosi pre-operatoria nellβottica di definire la strategia di trattamento piΓΉ opportuna.
|
[
{
"affiliation": null,
"collective": null,
"firstname": "Manuel",
"initials": "M",
"lastname": "Valeri"
},
{
"affiliation": null,
"collective": null,
"firstname": "Lavinia",
"initials": "L",
"lastname": "Amato"
},
{
"affiliation": null,
"collective": null,
"firstname": "Michela",
"initials": "M",
"lastname": "Boncompagni"
},
{
"affiliation": null,
"collective": null,
"firstname": "Roberto",
"initials": "R",
"lastname": "Ciaccarini"
},
{
"affiliation": null,
"collective": null,
"firstname": "Rachele",
"initials": "R",
"lastname": "Del Sordo"
},
{
"affiliation": null,
"collective": null,
"firstname": "Adolfo",
"initials": "A",
"lastname": "Petrina"
}
] |
Annali italiani di chirurgia
| null |
34636341
|
A rare finding of Actinomyces odontolyticus abdominal actinomycosis presenting as abdominal wall and pericolic pseudotumoral mass.
| null | null | null | null | null | null |
null | null |
10.1007/s00106-020-00876-3
10.1097/MAO.0000000000001734
10.1097/MAO.0000000000001038
10.1007/s00106-018-0531-4
10.3390/jcm8101614
10.1007/s00106-012-2652-5
10.1007/s11548-013-0973-9
10.1017/S0022215115002042
10.3109/00016480903559749
10.1016/j.ijporl.2018.05.033
10.1097/MAO.0b013e318291c651
10.1016/j.ijscr.2016.11.057
10.1007/s00330-015-3983-x
10.1371/journal.pone.0221484
10.1007/s00405-014-3452-1
10.1097/MAO.0000000000000347
10.1097/MAO.0000000000000405
10.1097/MAO.0000000000001834
10.1007/s00106-015-0087-5
10.1097/MAO.0000000000000881
10.2147/MDER.S39691
10.1097/MAO.0000000000000682
10.1097/MAO.0000000000001394
10.1186/s40463-018-0316-5
10.1097/MAO.0000000000001358
10.1111/coa.12484
10.3109/00016489.2014.900703
10.1080/00016489.2017.1420915
10.1179/1467010014Z.000000000155
10.1007/s00106-014-2851-3
10.1016/j.conctc.2018.03.007
10.1097/MAO.0000000000002201
10.1007/s00405-014-2976-8
10.1055/s-0035-1564329
| null |
[
"Hearing aids",
"Hearing loss, conductive",
"Hearing loss, mixed, conductive-sensorineural",
"Otologic surgical procedures",
"Patients"
] |
2020-06-07
|
Here, we describe the surgical technique for implanting a new, active, transcutaneous bone conduction hearing aid. The implant technology is based on a system that has been in use reliably since 2012. The geometry of the new implant has been adapted based on experience with previously introduced implants. The surgery was feasible, standardized, and safe. Due to the optimized geometric design that improved the bone fit, it is not necessary to use specialized, detailed preoperative planning, except in challenging anatomical conditions; e.g., in young children, malformations, poor pneumatization, or after a canal wall down mastoidectomy.
Im vorliegenden Beitrag wird die Technik der Implantation eines neuen aktiven, transkutanen, knochenverankerten HΓΆrimplantats beschrieben. Das HΓΆrimplantat basiert technisch auf einem System, das bereits seit 2012 zuverlΓ€ssig im Einsatz ist. Die Geometrie des neuen Systems ist an die Erfahrungen mit vorangegangenen Implantaten angepasst. Die Op. ist standardisiert und sicher durchfΓΌhrbar. Aufgrund der optimierten Bauform mit verbesserter PassfΓ€higkeit im SchlΓ€fenbein erscheint eine spezielle, detaillierte prΓ€operative Planung der Implantation nur noch in FΓ€llen mit besonderen anatomischen Gegebenheiten, wie z.β―B. bei Kindern, bei Fehlbildungen, bei schlechter Pneumatisation des SchlΓ€fenbeins und nach Anlage einer offenen MastoidhΓΆhle notwendig.
|
[
{
"affiliation": "UniversitΓ€tsklinik und Poliklinik fΓΌr Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie, UniversitΓ€tsmedizin Halle, Martin-Luther-UniversitΓ€t Halle-Wittenberg, Ernst-Grube-Str.Β 40, 06120, Halle (Saale), Deutschland. [email protected].",
"collective": null,
"firstname": "S K",
"initials": "SK",
"lastname": "Plontke"
},
{
"affiliation": "UniversitΓ€tsklinik und Poliklinik fΓΌr Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie, UniversitΓ€tsmedizin Halle, Martin-Luther-UniversitΓ€t Halle-Wittenberg, Ernst-Grube-Str.Β 40, 06120, Halle (Saale), Deutschland.",
"collective": null,
"firstname": "G",
"initials": "G",
"lastname": "GΓΆtze"
},
{
"affiliation": "UniversitΓ€tsklinik und Poliklinik fΓΌr Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie, UniversitΓ€tsmedizin Halle, Martin-Luther-UniversitΓ€t Halle-Wittenberg, Ernst-Grube-Str.Β 40, 06120, Halle (Saale), Deutschland.",
"collective": null,
"firstname": "C",
"initials": "C",
"lastname": "Wenzel"
},
{
"affiliation": "UniversitΓ€tsklinik und Poliklinik fΓΌr Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie, UniversitΓ€tsmedizin Halle, Martin-Luther-UniversitΓ€t Halle-Wittenberg, Ernst-Grube-Str.Β 40, 06120, Halle (Saale), Deutschland.",
"collective": null,
"firstname": "T",
"initials": "T",
"lastname": "Rahne"
},
{
"affiliation": "UniversitΓ€tsklinik und Poliklinik fΓΌr Hals-Nasen-Ohren-Heilkunde \"Otto KΓΆrner\", UniversitΓ€tsmedizin Rostock, Rostock, Deutschland.",
"collective": null,
"firstname": "R",
"initials": "R",
"lastname": "Mlynski"
}
] |
HNO
| null |
32504115
|
[Implantation of aΒ new active bone conduction hearing device with optimized geometry. German version].
| null | null | null | null | null | null |
By identifying obstacles related to the professional setting, patient behavior, and organization of care, our study identified resources and a framework for establishing collaborative strategies to facilitate follow-up care of childhood cancer survivors in China.
| null |
10.1200/GO.20.00534
10.1148/radiol.2020200905
|
The Delphi survey identified eight high-priority late effects for harmonization within CCCG: osteonecrosis, osteoporosis, left ventricular dysfunction, secondary brain tumors, treatment-related myeloid leukemia, gonadal dysfunction, growth hormone deficiency, and neurocognitive deficits. The common barriers to implementing survivorship programs include lack of support and resources for clinicians to provide follow-up care. Patients were also concerned about privacy issues and lacked awareness of late effects. Many institutions also lacked rehabilitation expertise and referral pathways.
|
[] |
2021-02-17
|
Survivors of childhood cancer often experience treatment-related chronic health conditions. Given its vast population, China shares a large proportion of the global childhood cancer burden. Yet, screening and treatment of late effects in survivors of childhood cancer remain underaddressed in most regions of China. This study aimed to identify high-priority late effects for harmonizing screening guidelines within the Chinese Children's Cancer Group (CCCG), as well as barriers and enablers of the implementation of surveillance recommendations in local practice.
To establish clinical consensus, 12 expert panelists who represent major institutions within the CCCG completed a Delphi survey and participated in a focus group discussion. The survey solicited ratings of the prevalence, severity, and priority for screening of 45 late effects. Major themes identified from the focus group were analyzed using thematic analysis.
The Delphi survey identified eight high-priority late effects for harmonization within CCCG: osteonecrosis, osteoporosis, left ventricular dysfunction, secondary brain tumors, treatment-related myeloid leukemia, gonadal dysfunction, growth hormone deficiency, and neurocognitive deficits. The common barriers to implementing survivorship programs include lack of support and resources for clinicians to provide follow-up care. Patients were also concerned about privacy issues and lacked awareness of late effects. Many institutions also lacked rehabilitation expertise and referral pathways.
By identifying obstacles related to the professional setting, patient behavior, and organization of care, our study identified resources and a framework for establishing collaborative strategies to facilitate follow-up care of childhood cancer survivors in China.
|
[
{
"affiliation": "School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.",
"collective": null,
"firstname": "Yin Ting",
"initials": "YT",
"lastname": "Cheung"
},
{
"affiliation": "Department of Hematology and Oncology, Guangzhou Women and Children's Medical Center, Guangzhou, China.",
"collective": null,
"firstname": "Hui",
"initials": "H",
"lastname": "Zhang"
},
{
"affiliation": "Key Laboratory of Pediatric Hematology and Oncology Ministry of Health, Department of Hematology and Oncology, Pediatric Translational Medicine Institute, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.",
"collective": null,
"firstname": "Jiaoyang",
"initials": "J",
"lastname": "Cai"
},
{
"affiliation": "School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.",
"collective": null,
"firstname": "Lung Wai Phillip",
"initials": "LWP",
"lastname": "Au-Doung"
},
{
"affiliation": "School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.",
"collective": null,
"firstname": "Lok Sum",
"initials": "LS",
"lastname": "Yang"
},
{
"affiliation": "Department of Hematology and Oncology, Guangzhou Women and Children's Medical Center, Guangzhou, China.",
"collective": null,
"firstname": "Cuixia",
"initials": "C",
"lastname": "Yan"
},
{
"affiliation": "Pediatric Department, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.",
"collective": null,
"firstname": "Fen",
"initials": "F",
"lastname": "Zhou"
},
{
"affiliation": "State Key Laboratory of Experimental Hematology, Department of Paediatrics Haematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.",
"collective": null,
"firstname": "Xiaojuan",
"initials": "X",
"lastname": "Chen"
},
{
"affiliation": "Division of Hematology, Children's Hospital, Chongqing Medical University, Chongqing, China.",
"collective": null,
"firstname": "Xianmin",
"initials": "X",
"lastname": "Guan"
},
{
"affiliation": "Department of Oncology, St Jude Children's Research Hospital, Memphis, TN.",
"collective": null,
"firstname": "Ching-Hon",
"initials": "CH",
"lastname": "Pui"
},
{
"affiliation": "Department of Oncology, St Jude Children's Research Hospital, Memphis, TN.\nDepartment of Epidemiology and Cancer Control, St Jude Children's Research Hospital, Memphis, TN.",
"collective": null,
"firstname": "Melissa M",
"initials": "MM",
"lastname": "Hudson"
},
{
"affiliation": "Department of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.\nHong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong, Hong Kong.\nDepartment of Paediatrics and Adolescent Medicine, Hong Kong Children's Hospital, Hong Kong.",
"collective": null,
"firstname": "Chi-Kong",
"initials": "CK",
"lastname": "Li"
}
] |
JCO global oncology
| null |
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29226000
22586152
|
Identifying Priorities for Harmonizing Guidelines for the Long-Term Surveillance of Childhood Cancer Survivors in the Chinese Children Cancer Group (CCCG).
| null | null | null | null | null | null |
null |
Copyright Β© 2022 by The Author(s). Published by S. Karger AG, Basel.
|
10.1159/000527094
| null |
[
"En face imaging",
"Hypotony maculopathy",
"Ocular trauma",
"Traumatic cyclodialysis",
"Ultra-widefield optical coherence tomography"
] |
2022-12-06
|
The aim was to investigate the structural changes of the retina using en face ultra-widefield optical coherence tomography (OCT) images during the treatment of hypotony maculopathy with traumatic cyclodialysis. Case 1 was a 43-year-old male patient with visual crowding in his left eye (metallic wire injury that occurred 3 weeks previously) who was referred to our department. Although best-corrected visual acuity was 20/20 in his left eye on initial evaluation, intraocular pressure was 6 mm Hg. Case 2 was a 20-year-old male patient with visual crowding in his left eye (baseball ball injury that occurred 4 weeks previously) who was referred to our department. Although best-corrected visual acuity was 16/20 in his left eye on initial examination, intraocular pressure was 5 mm Hg. Surgical interventions were performed in both cases. En face ultra-widefield OCT images were able to be used to trace dynamic changes before the intervention and up to 1 year later. The images obtained in these two cases made it possible to confirm the progress from wrinkles on the surface of the retina to normalization of vascular structure and improvement of ellipsoid zone disruption. En face ultra-widefield OCT is useful for monitoring multilayer structures of the retina in hypotony maculopathy cases.
|
[
{
"affiliation": "Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Osaka City University, Osaka, Japan.",
"collective": null,
"firstname": "Yuri",
"initials": "Y",
"lastname": "Nagatomi"
},
{
"affiliation": "Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Osaka City University, Osaka, Japan.",
"collective": null,
"firstname": "Mizuki",
"initials": "M",
"lastname": "Tagami"
},
{
"affiliation": "Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Osaka City University, Osaka, Japan.",
"collective": null,
"firstname": "Norihiko",
"initials": "N",
"lastname": "Misawa"
},
{
"affiliation": "Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Osaka City University, Osaka, Japan.",
"collective": null,
"firstname": "Atsushi",
"initials": "A",
"lastname": "Sakai"
},
{
"affiliation": "Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Osaka City University, Osaka, Japan.",
"collective": null,
"firstname": "Yusuke",
"initials": "Y",
"lastname": "Haruna"
},
{
"affiliation": "Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Osaka City University, Osaka, Japan.",
"collective": null,
"firstname": "Shigeru",
"initials": "S",
"lastname": "Honda"
}
] |
Case reports in ophthalmology
| null |
36466068
1945314
20051856
17542978
26457396
27749497
29631900
23196648
|
En Face Images Using Ultra-Widefield Optical Coherence Tomography in 2 Cases of Traumatic Hypotony Maculopathy before and after Surgical Intervention.
| null | null | null | null | null | null |
The median recovery time was longer than other similar studies. Therefore, due attention should be given to the identified predictors of the recovery time.
|
Copyright: Β© 2025 Bekele et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
|
10.1371/journal.pone.0316839
10.1016/S2214-109X(18)30408-X
10.1016/S0140-6736(10)60224-6
10.1371/journal.pone.0213238
10.2147/PHMT.S321184
10.2471/blt.07.044545
10.7189/jogh.06.010408
10.1371/journal.pone.0207203
10.7196/sajch.663
10.1016/S0140-6736(03)13779-8
10.1155/2020/1606783
10.1177/20503121221078445
10.17140/goroj-8-157
10.4103/jfmpc.jfmpc_2006_21
10.1155/2015/167261
10.1016/j.heliyon.2020.e04732
10.1186/s12889-022-14842-x
10.54724/lc.2023.e8
10.1371/journal.pone.0239655
10.1371/journal.pone.0122052
10.21101/cejph.a4164
10.3390/ijerph192416733
10.1186/s12887-023-04144-5
10.1097/INF.0b013e3181906e40
10.1371/journal.pone.0243636
| null |
[] |
2025-04-15
|
Pneumonia is an inflammation of lung parenchyma. The World Health Organization estimated 156 million cases of pneumonia occur annually. Out of them, 20 million cases severe enough to require hospitalization, and each year 1.2 million deaths occur among under-five children. Despite studies and initiatives aimed at reducing pneumonia related deaths in children, Ethiopia is ranked sixth among top fifteen countries in terms of pneumonia related morbidity and mortality.
This study aimed to assess the time to recovery from severe pneumonia and its predictors among children aged 2-59 months admitted to the pediatric ward of Jimma University Medical Center; Southwest, Ethiopia, 2023.
A facility-based retrospective cohort study was carried out among 426 children aged between 2 and 59 months. Five years of medical records, from 2018-2022, were reviewed. A simple random sampling technique was used. Data entry was done in Epidata version 4.6 and exported to and analyzed by STATA version 15. Variables with p-value <β 0.25 at Bivariable Cox regression analysis were selected for the multivariable Cox proportional model. A multivariable Cox regression model with 95% confidence interval and Adjusted Hazard Ratio was used to identify a significant predictor of time to recovery at a p-value <β 0.05.
The median recovery time was 4 days (IQR: 3, 7). Incidence rate of recovery was 15.78 per 100-person day (95% CI 14.2-17.5). The presence of co-morbidity (AHR; 0.7, 95% CI (0.54-0.91)), being treated with Ceftazidime and Vancomycin (AHR; 0.29, 95% CI (0.14-0.60)), antibiotic change (AHR; 0.74, 95% CI (0.58-0.95)) and late presentation to the Hospital (AHR; 0.58, 95% CI (0.43-0.78)) were statistically significant predictors that prolong recovery time.
The median recovery time was longer than other similar studies. Therefore, due attention should be given to the identified predictors of the recovery time.
|
[
{
"affiliation": "Jimma University Medical Center, Jimma, Ethiopia.",
"collective": null,
"firstname": "Getu Girma",
"initials": "GG",
"lastname": "Bekele"
},
{
"affiliation": "Jimma University Medical Center, Jimma, Ethiopia.",
"collective": null,
"firstname": "Tola Getachew",
"initials": "TG",
"lastname": "Bekele"
},
{
"affiliation": "Jimma University, Institute of Health, Faculty of Public Health, Department of Epidemiology, Jimma, Ethiopia.",
"collective": null,
"firstname": "Masrie",
"initials": "M",
"lastname": "Getnet"
},
{
"affiliation": "Jimma University, Institute of Health, Faculty of Public Health, Department of Epidemiology, Jimma, Ethiopia.",
"collective": null,
"firstname": "Dawit",
"initials": "D",
"lastname": "Regassa"
}
] |
PloS one
| null |
40233064
|
Time-to-recovery from severe pneumonia and its predictors among children 2-59 months of age admitted to the pediatric ward of Jimma University Medical Center, Southwest Ethiopia, 2023: A retrospective cohort study.
| null | null | null | null | null | null |
null | null |
10.3390/cancers17040711
10.1634/theoncologist.2014-0113
10.1002/hon.2711
10.1093/annonc/mdf662
10.1111/j.1600-0609.2005.00438.x
10.1007/s00277-017-2940-y
10.1007/s11136-010-9670-0
10.1385/MO:18:1:85
10.1007/s11764-007-0004-3
10.3390/cancers15153885
10.1016/S0140-6736(85)92589-9
10.2466/pr0.97.1.195-202
10.1002/cam4.1338
10.1080/00207599008247865
10.1111/tri.12895
10.1002/cncr.22581
10.1007/s11136-006-0025-9
10.1097/00005650-199303000-00006
10.1186/s12939-022-01622-7
10.1016/S0959-8049(98)00136-1
10.1111/j.1365-2354.2004.00546.x
10.1183/09031936.00059814
10.1097/00005768-199911001-00019
10.1007/s00520-023-07691-w
10.1080/01635581.2021.1881570
10.1200/OP.21.00694
10.1182/hematology.2020000100
10.3390/curroncol30110692
10.1186/s12889-021-10433-4
10.1186/1477-7525-1-44
| null |
[
"non-Hodgkin lymphoma",
"population-based data",
"quality of life"
] |
2025-02-26
|
Background/Objectives: Non-Hodgkin lymphoma (NHL) represents 63% of all hematological malignancies in France, with diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) being the two most frequent forms. With the improvement of therapeutics, the issue of health-related quality of life (HRQoL) is becoming increasingly crucial for these patients. The aim was to compare HRQoL of NHL survivors with that of the general French population and to identify factors associated with HRQoL in NHL survivors. Methods: We conducted a population-based study among living patients from three registries of hematological malignancies, using standardized questionnaires, including the SF-12, in September 2023. The data collected were compared to those of a normative general French cohort. Results: In total, 493 patients completed the study questionnaires, yielding a response rate of 36%. The median time since diagnosis was 8 years (IQR 6-10) These NHL survivors reported lower HRQoL compared to the general French population, except in terms of bodily pain (p < 0.01). Each one-year increase in the time since diagnosis was associated with an increase in social functioning (p = 0.009). Men had better general health (p = 0.01) and less bodily pain (p = 0.007) than women. Higher income was associated with better HRQoL (p < 0.01). Underweight or obesity were associated with poorer physical functioning (p = 0.008). The presence of comorbidities, socioeconomic deprivation, anxiety, and depression were associated with poorer HRQoL (p < 0.01). Conclusions: This study provides valuable information of HRQoL values for comparison in further follow-up studies and proposes measures that could be implemented to improve the HRQoL of NHL survivors.
|
[
{
"affiliation": "Registry of Hematological Malignancies of CΓ΄te d'Or, Dijon-Bourgogne University Hospital, 21000 Dijon, France.\nINSERM, UMR1231, Bourgogne Franche-ComtΓ© University, 21000 Dijon, France.",
"collective": null,
"firstname": "Stephane Kroudia",
"initials": "SK",
"lastname": "Wasse"
},
{
"affiliation": "INSERM, UMR1231, Bourgogne Franche-Comté University, 21000 Dijon, France.\nBreast and Gynecologic Cancer Registry of Côte d'Or, Georges François Leclerc Comprehensive Cancer Centre, 21000 Dijon, France.",
"collective": null,
"firstname": "Emerline",
"initials": "E",
"lastname": "Assogba"
},
{
"affiliation": "Registry of Hematological Malignancies of Gironde, BergoniΓ© Institute, 33076 Bordeaux, France.",
"collective": null,
"firstname": "Sebastien",
"initials": "S",
"lastname": "Orazio"
},
{
"affiliation": "Registry of Hematological Malignancies of CΓ΄te d'Or, Dijon-Bourgogne University Hospital, 21000 Dijon, France.\nINSERM, UMR1231, Bourgogne Franche-ComtΓ© University, 21000 Dijon, France.",
"collective": null,
"firstname": "Kueshivi Midodji",
"initials": "KM",
"lastname": "Atsou"
},
{
"affiliation": "Clinical Hematology Unit, Dijon Bourgogne University Hospital, 21000 Dijon, France.",
"collective": null,
"firstname": "CΓ©dric",
"initials": "C",
"lastname": "Rossi"
},
{
"affiliation": "Registry of Hematological Malignancies of CΓ΄te d'Or, Dijon-Bourgogne University Hospital, 21000 Dijon, France.\nINSERM, UMR1231, Bourgogne Franche-ComtΓ© University, 21000 Dijon, France.",
"collective": null,
"firstname": "Adrien",
"initials": "A",
"lastname": "Guilloteau"
},
{
"affiliation": "Registry of Hematological Malignancies of CΓ΄te d'Or, Dijon-Bourgogne University Hospital, 21000 Dijon, France.\nINSERM, UMR1231, Bourgogne Franche-ComtΓ© University, 21000 Dijon, France.",
"collective": null,
"firstname": "Sophie",
"initials": "S",
"lastname": "Gauthier"
},
{
"affiliation": "Registry of Hematological Malignancies of CΓ΄te d'Or, Dijon-Bourgogne University Hospital, 21000 Dijon, France.\nINSERM, UMR1231, Bourgogne Franche-ComtΓ© University, 21000 Dijon, France.",
"collective": null,
"firstname": "StΓ©phanie",
"initials": "S",
"lastname": "Girard"
},
{
"affiliation": "Registry of Hematological Malignancies of Caen, Caen University Hospital, 14000 Caen, France.",
"collective": null,
"firstname": "Jean-Marc",
"initials": "JM",
"lastname": "Poncet"
},
{
"affiliation": "Registry of Hematological Malignancies of Caen, Caen University Hospital, 14000 Caen, France.\nClinical Hematology Unit, Caen University Hospital, 14000 Caen, France.",
"collective": null,
"firstname": "Gandhi",
"initials": "G",
"lastname": "Damaj"
},
{
"affiliation": "Registry of Hematological Malignancies of Caen, Caen University Hospital, 14000 Caen, France.",
"collective": null,
"firstname": "Xavier",
"initials": "X",
"lastname": "Troussard"
},
{
"affiliation": "Clinical Hematology Unit, Caen University Hospital, 14000 Caen, France.",
"collective": null,
"firstname": "Alain",
"initials": "A",
"lastname": "Monnereau"
},
{
"affiliation": "Breast and Gynecologic Cancer Registry of Côte d'Or, Georges François Leclerc Comprehensive Cancer Centre, 21000 Dijon, France.\nClinical Hematology Unit, Dijon Bourgogne University Hospital, 21000 Dijon, France.",
"collective": null,
"firstname": "Sandrine Tienhan",
"initials": "ST",
"lastname": "Dabakuyo-Yonli"
},
{
"affiliation": "Registry of Hematological Malignancies of CΓ΄te d'Or, Dijon-Bourgogne University Hospital, 21000 Dijon, France.\nINSERM, UMR1231, Bourgogne Franche-ComtΓ© University, 21000 Dijon, France.",
"collective": null,
"firstname": "Marc",
"initials": "M",
"lastname": "Maynadie"
}
] |
Cancers
| null |
40002304
|
Health-Related Quality of Life in Long-Term Survivors of Non-Hodgkin Lymphoma: A French Population-Based Study.
| null | null | null | null | null | null |
null |
Copyright Β© 2025 Elsevier B.V. All rights reserved.
|
10.1016/j.chroma.2025.465658
| null |
[
"Blood-brain barrier",
"Chiral separation",
"Evodiamine",
"Stereoselectivity"
] |
2025-01-15
|
Evodiamine, a chiral quinazoline alkaloid in the traditional Chinese medicine Evodiae fructus, exhibited efficacy for CNS diseases. In this study, the pure enantiomers of evodiamine were prepared in large quantities via chemical resolution. Their structures were elucidated by MS, NMR and ECD. The optical purity was determined to be as high as 99.8 %. The differences of the enantiomers in protective effect against neuronal cell injury were evaluated using MTT assay. Notably, R-(-)-evodiamine showed better neuroprotection effects against H
|
[
{
"affiliation": "School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, PR China. Electronic address: [email protected].",
"collective": null,
"firstname": "Ming",
"initials": "M",
"lastname": "Chen"
},
{
"affiliation": "School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, PR China. Electronic address: [email protected].",
"collective": null,
"firstname": "Yiwen",
"initials": "Y",
"lastname": "Zhang"
},
{
"affiliation": "School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, PR China. Electronic address: [email protected].",
"collective": null,
"firstname": "Xuhua",
"initials": "X",
"lastname": "Qi"
},
{
"affiliation": "Shenyang No.40 High school, Shenyang 110034, PR China. Electronic address: [email protected].",
"collective": null,
"firstname": "Mingyue",
"initials": "M",
"lastname": "Ma"
},
{
"affiliation": "School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, PR China. Electronic address: [email protected].",
"collective": null,
"firstname": "Yan",
"initials": "Y",
"lastname": "Cui"
}
] |
Journal of chromatography. A
| null |
39808905
|
Stereoselectivity of evodiamine enantiomers in neuroprotective activity, pharmacokinetics and the ability across the blood-brain barrier.
| null | null | null | null | null | null |
null |
Copyright Β© 2024 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. All Rights Reserved.
|
10.1097/CCM.0000000000006437
| null |
[] |
2024-10-04
|
Neurocritically ill patients are at high risk for developing delirium, which can worsen the long-term outcomes of this vulnerable population. However, existing delirium assessment tools do not account for neurologic deficits that often interfere with conventional testing and are therefore unreliable in neurocritically ill patients. We aimed to determine the accuracy and predictive validity of the Fluctuating Mental Status Evaluation (FMSE), a novel delirium screening tool developed specifically for neurocritically ill patients.
Prospective validation study.
Neurocritical care unit at an academic medical center.
One hundred thirty-nine neurocritically ill stroke patients (mean age, 63.9 [ sd , 15.9], median National Institutes of Health Stroke Scale score 11 [interquartile range, 2-17]).
None.
Expert raters performed daily Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition-based delirium assessments, while paired FMSE assessments were performed by trained clinicians. We analyzed 717 total noncomatose days of paired assessments, of which 52% ( n = 373) were rated by experts as days with delirium; 53% of subjects were delirious during one or more days. Compared with expert ratings, the overall accuracy of the FMSE was high (area under the curve [AUC], 0.85; 95% CI, 0.82-0.87). FMSE scores greater than or equal to 1 had 86% sensitivity and 74% specificity on a per-assessment basis, while scores greater than or equal to 2 had 70% sensitivity and 88% specificity. Accuracy remained high in patients with aphasia (FMSE β₯ 1: 82% sensitivity, 64% specificity; FMSE β₯ 2: 64% sensitivity, 84% specificity) and those with decreased arousal (FMSE β₯ 1: 87% sensitivity, 77% specificity; FMSE β₯ 2: 71% sensitivity, 90% specificity). Positive FMSE assessments also had excellent accuracy when predicting functional outcomes at discharge (AUC, 0.86 [95% CI, 0.79-0.93]) and 3 months (AUC, 0.85 [95% CI, 0.78-0.92]).
In this validation study, we found that the FMSE was an accurate delirium screening tool in neurocritically ill stroke patients. FMSE scores greater than or equal to 1 indicate "possible" delirium and should be used when prioritizing sensitivity, whereas scores greater than or equal to 2 indicate "probable" delirium and should be used when prioritizing specificity.
|
[
{
"affiliation": "Center for Research, Investigation, and Systems Modeling of Acute Illness (CRISMA), University of Pittsburgh School of Medicine, Pittsburgh, PA.\nDepartment of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA.\nDepartment of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA.",
"collective": null,
"firstname": "Michael E",
"initials": "ME",
"lastname": "Reznik"
},
{
"affiliation": "Department of Psychiatry and Human Behavior, Brown University, Alpert Medical School, Providence, RI.",
"collective": null,
"firstname": "Seth A",
"initials": "SA",
"lastname": "Margolis"
},
{
"affiliation": "Department of Neurology, Brown University, Alpert Medical School, Providence, RI.",
"collective": null,
"firstname": "Nicholas",
"initials": "N",
"lastname": "Andrews"
},
{
"affiliation": "Department of Neurology, Brown University, Alpert Medical School, Providence, RI.",
"collective": null,
"firstname": "Colin",
"initials": "C",
"lastname": "Basso"
},
{
"affiliation": "Department of Neurology, Brown University, Alpert Medical School, Providence, RI.",
"collective": null,
"firstname": "Noa",
"initials": "N",
"lastname": "Mintz"
},
{
"affiliation": "Department of Neurology, Brown University, Alpert Medical School, Providence, RI.",
"collective": null,
"firstname": "Sean",
"initials": "S",
"lastname": "Varga"
},
{
"affiliation": "Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA.",
"collective": null,
"firstname": "Beth E",
"initials": "BE",
"lastname": "Snitz"
},
{
"affiliation": "Center for Research, Investigation, and Systems Modeling of Acute Illness (CRISMA), University of Pittsburgh School of Medicine, Pittsburgh, PA.\nDepartment of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA.",
"collective": null,
"firstname": "Timothy D",
"initials": "TD",
"lastname": "Girard"
},
{
"affiliation": "Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA.",
"collective": null,
"firstname": "Lori A",
"initials": "LA",
"lastname": "Shutter"
},
{
"affiliation": "Critical Illness, Brain Dysfunction, and Survivorship (CIBS) Center, Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.\nTennessee Valley Veterans Affairs Geriatric Research Education Clinical Center (GRECC), Nashville, TN.",
"collective": null,
"firstname": "E Wesley",
"initials": "EW",
"lastname": "Ely"
},
{
"affiliation": "Department of Psychiatry and Human Behavior, Brown University, Alpert Medical School, Providence, RI.\nDepartment of Neurology, Brown University, Alpert Medical School, Providence, RI.",
"collective": null,
"firstname": "Richard N",
"initials": "RN",
"lastname": "Jones"
}
] |
Critical care medicine
| null |
39365697
|
Validating the Fluctuating Mental Status Evaluation in Neurocritically Ill Patients With Acute Stroke.
| null | null | null | null | null | null |
null | null |
10.3390/ijms20153622
10.1016/j.addr.2018.04.017
10.1002/jor.23499
10.1007/s007760100006
10.1097/00007632-199506000-00022
10.1007/s10495-013-0839-1
10.1371/journal.pone.0049995
10.1016/j.spinee.2012.12.003
10.1016/j.copbio.2013.04.012
10.5966/sctm.2016-0033
10.1097/01.brs.0000174530.88585.32
10.1016/j.addr.2014.08.008
10.22203/eCM.v025a01
10.1111/j.1533-2500.2007.00171.x
10.1111/j.1469-7580.2012.01521.x
10.1111/joa.12258
10.1097/BRS.0b013e31818e5ddd
10.1186/ar629
10.1002/art.20236
10.1016/j.spinee.2004.07.010
10.1016/S0945-053X(01)00184-6
10.1097/MD.0000000000009149
10.1093/rheumatology/ken396
10.1002/jlb.67.2.149
10.1016/0142-9612(96)84936-2
10.3174/ajnr.A4173
10.1016/j.jpain.2017.06.002
10.1089/ten.teb.2009.0451
10.2106/JBJS.M.00141
10.1111/j.1469-7580.2012.01551.x
10.1097/BSD.0000000000000328
10.1243/0954411001535219
10.1080/17453670610045902
10.3109/03008207.2014.942419
10.1097/01.brs.0000146101.53784.b1
10.1097/01.brs.0000146499.97948.52
10.1016/j.amjmed.2009.05.028
10.22203/eCM.v020a25
10.1002/jbm.b.32712
10.1016/j.spinee.2004.12.004
10.3171/SPI/2008/8/2/115
10.1016/j.spinee.2005.02.021
10.1002/term.2750
10.2217/rme-2016-0069
10.1186/s40824-017-0106-6
10.1515/bmc-2018-0003
10.1126/scitranslmed.aau0670
10.1016/j.joca.2015.08.014
10.1007/s00586-011-1697-6
10.1016/J.ENG.2017.01.010
10.1155/2014/489128
10.1016/j.biomaterials.2007.07.028
10.1089/ten.teb.2013.0537
10.1016/j.jbiomech.2015.10.015
10.1016/j.clinbiochem.2009.06.017
10.1097/BRS.0b013e31823c8603
10.1016/j.spinee.2006.11.006
10.1080/03008207.2017.1282951
10.1111/j.1745-7270.2006.00230.x
10.3340/jkns.2008.44.5.327
10.1097/01.brs.0000263369.95182.19
10.1097/01.brs.0000176319.78887.64
10.1016/j.spinee.2007.04.021
10.1097/00007632-200206150-00014
10.1097/01.brs.0000148002.68656.4d
10.1097/01.brs.0000206358.66412.7b
10.1002/jor.20339
10.1186/s13075-015-0625-2
10.1002/term.2111
10.1097/01.brs.0000248428.22823.86
10.1159/000369670
10.1186/1746-6148-10-3
10.1097/01.BRS.0000107231.67854.9F
10.1002/art.27733
10.1155/2015/427138
10.1016/j.joca.2013.07.017
10.1007/s00264-014-2664-8
10.1016/j.addr.2014.06.009
10.1007/s00586-006-0149-1
10.1007/s00167-012-1977-7
10.22203/eCM.v027sa02
10.1002/jor.21534
10.3171/2012.10.SPINE12512
10.1016/j.jot.2017.03.003
10.1002/jor.21036
10.1016/j.actbio.2018.03.019
10.1097/01.brs.0000146462.92171.7f
10.1016/j.bioeng.2006.07.002
10.1002/jor.23268
10.1016/j.jot.2017.02.002
10.1097/01.brs.0000184365.28481.e3
10.1097/BRS.0b013e3181d10401
10.1097/BRS.0b013e3181a54157
10.1016/j.ijsu.2016.02.045
10.1634/stemcells.2007-0374
10.1177/2050312118761674
10.1055/s-0036-1583174
10.1007/s00586-011-2026-9
10.1038/srep45623
10.1615/CritRevEukarGeneExpr.v21.i1.30
10.22203/eCM.v030a10
10.1002/jor.21147
10.1002/adma.200501612
10.1155/2018/4368910
10.1016/j.actbio.2017.01.036
10.1002/jor.23351
10.1089/ten.tea.2008.0215
10.1016/j.biomaterials.2013.08.072
10.1177/0885328213515034
10.1371/journal.pone.0185716
10.1016/j.actbio.2018.08.004
10.1007/s00264-018-4245-8
| null |
[
"intervertebral disc",
"nucleus pulposus",
"repair",
"replacement",
"scaffold"
] |
2019-07-28
|
Chronic back pain is a common disability, which is often accredited to intervertebral disc degeneration. Gold standard interventions such as spinal fusion, which are mainly designed to mechanically seal the defect, frequently fail to restore the native biomechanics. Moreover, artificial implants have limited success as a repair strategy, as they do not alter the underlying disease and fail to promote tissue integration and subsequent native biomechanics. The reported high rates of spinal fusion and artificial disc implant failure have pushed intervertebral disc degeneration research in recent years towards repair strategies. Intervertebral disc repair utilizing principles of tissue engineering should theoretically be successful, overcoming the inadequacies of artificial implants. For instance, advances in the development of scaffolds aided with cells and growth factors have opened up new possibilities for repair strategies. However, none has reached the stage of clinical trials in humans. In this review, we describe the hitches encountered in the musculoskeletal field and summarize recent advances in designing tissue-engineered constructs for promoting nucleus pulposus repair. Additionally, the review focuses on the effect of biomaterial aided with cells and growth factors on achieving effective functional reparative potency, highlighting the ways to enhance the efficacy of these treatments.
|
[
{
"affiliation": "Siegfried Weller Institute for Trauma Research at the BG Unfallklinik TΓΌbingen, Eberhard Karls UniversitΓ€t TΓΌbingen, Schnarrenbergstrasse 95, 72076 TΓΌbingen, Germany.",
"collective": null,
"firstname": "Gauri",
"initials": "G",
"lastname": "Tendulkar"
},
{
"affiliation": "Siegfried Weller Institute for Trauma Research at the BG Unfallklinik TΓΌbingen, Eberhard Karls UniversitΓ€t TΓΌbingen, Schnarrenbergstrasse 95, 72076 TΓΌbingen, Germany.",
"collective": null,
"firstname": "Tao",
"initials": "T",
"lastname": "Chen"
},
{
"affiliation": "Siegfried Weller Institute for Trauma Research at the BG Unfallklinik TΓΌbingen, Eberhard Karls UniversitΓ€t TΓΌbingen, Schnarrenbergstrasse 95, 72076 TΓΌbingen, Germany.",
"collective": null,
"firstname": "Sabrina",
"initials": "S",
"lastname": "Ehnert"
},
{
"affiliation": "Siegfried Weller Institute for Trauma Research at the BG Unfallklinik TΓΌbingen, Eberhard Karls UniversitΓ€t TΓΌbingen, Schnarrenbergstrasse 95, 72076 TΓΌbingen, Germany.",
"collective": null,
"firstname": "Hans-Peter",
"initials": "HP",
"lastname": "Kaps"
},
{
"affiliation": "Siegfried Weller Institute for Trauma Research at the BG Unfallklinik TΓΌbingen, Eberhard Karls UniversitΓ€t TΓΌbingen, Schnarrenbergstrasse 95, 72076 TΓΌbingen, Germany. [email protected].",
"collective": null,
"firstname": "Andreas K",
"initials": "AK",
"lastname": "NΓΌssler"
}
] |
International journal of molecular sciences
| null |
31344903
29705378
28114734
11793173
7660243
23512131
23185509
23537454
23773764
28297581
16103829
25174310
23283636
18211591
22686699
25424497
19127156
12723977
16595436
15077255
15541661
11827789
29390319
18854342
10670574
8799500
25430861
28652204
19903086
23783211
22881295
26836484
23082846
10718048
16752278
25000273
15564918
15564919
20102998
20954128
22566484
16363077
18248282
25050691
16291129
30095863
27586197
29085662
29779014
30463917
26342641
21279392
17669487
24168395
26549765
24250727
19563795
22037529
18455111
28102712
17091194
19119470
17495773
16135982
18082466
12065981
15626976
16582847
17205567
26013758
26612824
17139221
25547527
24387033
14722406
20812336
26583105
26564465
23933379
25653173
24993611
16865380
22476522
24802611
21866573
23140128
29662798
19953600
29555463
15564911
16963315
27104885
29662795
28535552
16261113
20890267
19934809
26898133
17656642
29568524
28451504
21953383
28358123
21967331
26388616
20839317
28088667
27340938
18707229
24050877
24327349
29053719
30092378
30498908
|
Intervertebral Disc Nucleus Repair: Hype or Hope?
| null | null | null | null | null | null |
null |
Copyright Β© 2024 American Pharmacists Association. Published by Elsevier Inc. All rights reserved.
|
10.1016/j.xphs.2024.04.003
| null |
[
"Compaction",
"Drug effect(s)",
"Formulation",
"Granulation",
"Powder technology",
"Simulation",
"Solid dosage form(s)"
] |
2024-04-13
|
Roll compaction (RC) is a cost-effective dry granulation method, widely implemented in the pharmaceutical industry. In early formulation development however, when the material availability is limited, being able to predict the most important parameters in RC, like gap width and specific compaction force (SCF), to obtain a target ribbon solid fraction (SF) would significantly improve the formulation development efficiency as it would avoid the need of performing experiments on the roller compactor itself. However, at the present state of things, experiments on RC mechanical simulators present an overestimation of the target SF, when compared to roller compactor SF values. Although numerous correction approaches have been developed to improve the predictive performance of different mathematical models applied to the simulation experimental results, no study has collected a database wide enough to demonstrate the validity of a correction factor that allows to accurately simulate the compaction behavior of multicomponent mixtures. Here, 25 different formulations at 40 % drug load are compacted at different SCFs, both on a RC mimicking device (Styl'One Evolution) and on an actual roller compactor (Gerteis Mini-Pactor): following a similar approach as Reimer et al. and implementing a simplified version of the Johanson's mathematical model, 4 different correction factors are calculated, depending on how their material properties and pressure dependencies are considered. In conclusion, one correction factor is identified as the optimal trade-off between the SF prediction accuracy on the Gerteis Mini-Pactor and its applicability to a wide range of formulations, as it is independent of the material properties. This finding is particularly relevant when applied to scale-up to this specific roller compactor or early development processes of new formulations that have not been mechanically characterized yet.
|
[
{
"affiliation": "F. Hoffmann-La Roche AG, Dept. PTDC-F Pharmaceutical R&D, Grenzacherstrasse 124, 4070 Basel, Switzerland.",
"collective": null,
"firstname": "Fabia",
"initials": "F",
"lastname": "Arpago"
},
{
"affiliation": "F. Hoffmann-La Roche AG, Dept. PTDC-F Pharmaceutical R&D, Grenzacherstrasse 124, 4070 Basel, Switzerland. Electronic address: [email protected].",
"collective": null,
"firstname": "Agostino",
"initials": "A",
"lastname": "Dall'Ara"
}
] |
Journal of pharmaceutical sciences
| null |
38608725
|
Modeling of Styl'One Evolution Correction Factors for Multicomponent Mixtures Scaling-up to Roller Compaction.
| null | null | null | null | null | null |
null |
Β© 2024 The Authors.
|
10.1016/j.gastha.2023.12.008
| null |
[
"Abdominal Pain",
"Endoscopy",
"Hemangioma",
"Sigmoid Colon"
] |
2024-08-12
|
Hemangiomas in the gastrointestinal tract are extremely rare, benign vascular tumors, known for their associated complication of bleeding. They are usually difficult to diagnose, despite the characteristic definition of radiolucent phleboliths on radiology and purplish, tannish brown nodule or polyp on endoscopy. Surgical resection is the treatment of choice. We describe a rare case of sigmoid colon cavernous hemangioma in a 49-year-old male who underwent colonoscopy for lower abdominal pain and revealed a large pedunculated polyp in the sigmoid colon measuring 1.7 cm in diameter. The hemangioma was completely resected endoscopically via hot snare with a favorable outcome.
|
[
{
"affiliation": "Internal Medicine Department, King Hamad University Hospital, Busaiteen, Kingdom of Bahrain.",
"collective": null,
"firstname": "Noora",
"initials": "N",
"lastname": "Al-Khater"
},
{
"affiliation": "Internal Medicine Department, King Hamad University Hospital, Busaiteen, Kingdom of Bahrain.",
"collective": null,
"firstname": "Mohamed",
"initials": "M",
"lastname": "Mohamed"
},
{
"affiliation": "Internal Medicine Department, King Hamad University Hospital, Busaiteen, Kingdom of Bahrain.",
"collective": null,
"firstname": "Afra",
"initials": "A",
"lastname": "Juma"
},
{
"affiliation": "Gastroenterology and Hepatology Department, King Hamad University Hospital, Busaiteen, Kingdom of Bahrain.",
"collective": null,
"firstname": "Faisal",
"initials": "F",
"lastname": "Abubaker"
},
{
"affiliation": "Pathology Department, King Hamad University Hospital, Busaiteen, Kingdom of Bahrain.",
"collective": null,
"firstname": "Sameer",
"initials": "S",
"lastname": "Ansari"
}
] |
Gastro hep advances
| null |
39131147
20011316
31616236
22942801
34256425
11641173
7215080
30978732
|
Endoscopic Resection of a Cavernous Hemangioma in the Sigmoid Colon: A Case Report.
| null | null | null | null | null | null |
Venous diethylene glycol poisoning is characterized by oliguric acute renal failure, metabolic acidosis, digestive symptoms, nervous system impairment, and a high probability of anemia and WBC proliferation. Mortality is high. Correlative factors include preexisting severe liver disease, renal disease, and infection.
| null |
10.3748/wjg.14.3236
|
Of the 64 patients who received armillarisin-A, 15 were found to have DEG poisoning. Twelve poisoned patients died. After a mean of 5 d, the poisoned patients displayed acute renal failure. Metabolic acidosis occurred in 13 cases. BUN, Cr, and CO2 values were significantly elevated and exacerbation of digestive tract symptoms and/or symptom was noted in 11 cases. Neurological system impairment was observed in 10 cases after 2 wk. Compared to the 49 non-poisoned patients, the poisoned patients exhibited significantly lower RBC and Hb values and higher WBC count. Renal biopsy from the poisoned patients revealed acute tubular necrosis and interstitial nephritis. Significant differences in preexisting severe hepatitis, ascites, renal disease, and diuretic therapy were found between groups. Prior to diethylene glycol injections, the mean values for neutral granular cells, BUN, Cr, calcium and phosphorous ions differed significantly between groups.
|
[] |
2008-05-29
|
To analyze the clinical presentation of venous diethylene glycol (DEG) poisoning in patients with preexisting severe liver disease and factors that correlate with DEG poisoning.
Retrospective chart review was performed to analyze the epidemiology, clinical presentation, hepatorenal functions, hemodynamics and pathological characteristics of 64 patients with severe liver disease who received intravenous armillarisin-A, the solvent of which was DEG. Comparative analyses of correlating factors and causes for poisoning were based on the presence or absence of poisoning.
Of the 64 patients who received armillarisin-A, 15 were found to have DEG poisoning. Twelve poisoned patients died. After a mean of 5 d, the poisoned patients displayed acute renal failure. Metabolic acidosis occurred in 13 cases. BUN, Cr, and CO2 values were significantly elevated and exacerbation of digestive tract symptoms and/or symptom was noted in 11 cases. Neurological system impairment was observed in 10 cases after 2 wk. Compared to the 49 non-poisoned patients, the poisoned patients exhibited significantly lower RBC and Hb values and higher WBC count. Renal biopsy from the poisoned patients revealed acute tubular necrosis and interstitial nephritis. Significant differences in preexisting severe hepatitis, ascites, renal disease, and diuretic therapy were found between groups. Prior to diethylene glycol injections, the mean values for neutral granular cells, BUN, Cr, calcium and phosphorous ions differed significantly between groups.
Venous diethylene glycol poisoning is characterized by oliguric acute renal failure, metabolic acidosis, digestive symptoms, nervous system impairment, and a high probability of anemia and WBC proliferation. Mortality is high. Correlative factors include preexisting severe liver disease, renal disease, and infection.
|
[
{
"affiliation": "Department of Infectious Diseases, Third Affiliated Hospital of Sun Yet-Sen University, Tianhe Area, 600 Tianhe Road, Guangzhou 510060, Guangdong Province, China.",
"collective": null,
"firstname": "Bing-Liang",
"initials": "BL",
"lastname": "Lin"
},
{
"affiliation": null,
"collective": null,
"firstname": "Zhi-Xin",
"initials": "ZX",
"lastname": "Zhao"
},
{
"affiliation": null,
"collective": null,
"firstname": "Yu-Tian",
"initials": "YT",
"lastname": "Chong"
},
{
"affiliation": null,
"collective": null,
"firstname": "Jian-Guo",
"initials": "JG",
"lastname": "Li"
},
{
"affiliation": null,
"collective": null,
"firstname": "Xing",
"initials": "X",
"lastname": "Zuo"
},
{
"affiliation": null,
"collective": null,
"firstname": "Yu",
"initials": "Y",
"lastname": "Tao"
},
{
"affiliation": null,
"collective": null,
"firstname": "Tan-Qi",
"initials": "TQ",
"lastname": "Lou"
},
{
"affiliation": null,
"collective": null,
"firstname": "Zhi-Liang",
"initials": "ZL",
"lastname": "Gao"
}
] |
World journal of gastroenterology
| null |
18506932
|
Venous diethylene glycol poisoning in patients with preexisting severe liver disease in China.
| null | null | null | null | null | null |
null |
Β© 2025 The Authors. Published by American Chemical Society.
|
10.1021/acsomega.5c00013
10.1016/j.pmatsci.2022.100977
10.1002/pola.23870
10.1016/j.cej.2018.09.020
10.1021/acsmaterialslett.1c00277
10.1002/pol.20210134
10.1039/D0PY00928H
10.1002/pc.26518
10.1016/j.matpr.2020.09.742
10.1134/S0965545X19040096
10.1021/ma048465n
10.1002/app.21303
10.1016/j.polymer.2014.12.042
10.1016/j.compscitech.2015.10.023
10.1016/j.matchemphys.2013.05.018
10.1002/app.48471
10.1016/j.polymer.2015.04.002
10.1016/j.polymer.2009.05.006
10.1016/j.matdes.2010.11.034
10.1007/s10853-011-5724-0
10.1016/j.carbon.2013.03.050
10.1016/j.compscitech.2011.07.016
10.3144/expresspolymlett.2008.6
10.1021/nn9010472
10.1016/j.compositesa.2014.04.023
10.1016/j.matdes.2014.10.047
10.1016/j.compscitech.2005.04.021
10.1016/j.carbon.2007.11.051
10.3144/expresspolymlett.2014.51
10.1016/j.polymdegradstab.2016.03.021
10.1007/s10853-012-6803-6
10.1016/j.carbon.2012.07.021
10.1016/j.eurpolymj.2014.09.022
10.1016/j.carbon.2011.11.001
10.1016/j.compscitech.2007.11.001
10.1016/j.compositesb.2012.01.070
10.1016/j.jcis.2017.01.013
10.1002/smll.200901957
10.1088/0957-4484/17/6/003
10.1016/j.compscitech.2004.04.002
10.1016/j.compositesb.2019.04.015
10.1016/j.carbon.2019.01.063
10.1021/acsami.0c12110
10.1016/j.polymer.2019.121988
10.1021/acsomega.6b00517
10.1016/j.compositesa.2021.106419
10.1016/j.compscitech.2015.08.010
10.1039/C4RA11120F
10.1002/pat.4948
10.1007/s10904-019-01340-8
10.1080/25740881.2021.1959929
10.1016/j.rinp.2016.10.013
10.1177/0954008320907123
10.1016/j.compscitech.2022.109815
10.1016/j.polymertesting.2021.107275
10.3390/polym14010103
10.1016/j.matlet.2024.136206
10.1016/j.dib.2024.110169
10.1016/j.diamond.2020.108101
10.1016/j.cpc.2021.108171
10.1021/acs.macromol.1c01813
10.1021/acs.jpcb.8b01127
10.1021/acs.jcim.4c00730
10.1021/acs.macromol.0c02012
10.1002/polb.24539
10.1021/acsapm.1c01024
10.26434/chemrxiv-2024-9tqz2
10.1016/0026-265X(90)90027-3
10.1021/ma011360p
10.1021/ma901244d
10.1016/j.polymer.2016.05.059
10.1061/(ASCE)0893-1321(2008)21:3(162)
10.1002/pc.24137
10.1061/(ASCE)0893-1321(2007)20:2(75)
10.1021/acs.jpca.8b03826
10.1016/j.polymer.2010.10.033
10.1021/acs.jpcc.0c03509
10.1002/pol.20200442
10.1021/acs.langmuir.3c00262
10.1021/ma00130a018
10.1016/j.matt.2021.01.001
10.1016/j.pmatsci.2020.100710
10.1016/j.compositesb.2017.11.028
| null |
[] |
2025-04-21
|
Due to their excellent mechanical properties, epoxy composites are widely used in low-density applications. However, the brittle epoxy matrix often serves as the principal failure point. Matrix enhancements can be achieved by optimizing polymer combinations to maximize intermolecular interactions or by introducing fillers. While nanofillers such as clay, rubber, carbon nanotubes, and nanoplatelets enhance mechanical properties, they can lead to issues like agglomeration, voids, and poor load transfer. Quantum dots, being the smallest nanofillers, offer higher dispersion and the potential to promote intermolecular interactions, enhancing stiffness, strength, and toughness simultaneously. This study employed molecular dynamics simulations to design graphene quantum dot (GQD) reinforced epoxy nanocomposites. By functionalizing GQDs with oxygen-based groups-hydroxyl, epoxide, carboxyl, and mixed chemistries-their effects on the mechanical properties of nanocomposites were systematically evaluated. Results show that hydroxyl-functionalized GQDs provide optimal performance, increasing stiffness and yield strength by 18.4 and 56.1%, respectively. Structural analysis reveals that these GQDs promote a closely packed molecular configuration, resulting in reduced free volume.
|
[
{
"affiliation": "Department of Chemical and Materials Engineering, San Jose State University, San Jose, California 95192, United States.",
"collective": null,
"firstname": "Prathamesh P",
"initials": "PP",
"lastname": "Deshpande"
},
{
"affiliation": "Department of Chemical and Materials Engineering, San Jose State University, San Jose, California 95192, United States.",
"collective": null,
"firstname": "Robert",
"initials": "R",
"lastname": "Chan-Jobe"
},
{
"affiliation": "Department of Mechanical Engineering-Engineering Mechanics, Michigan Technological University, Houghton, Michigan 49931, United States.",
"collective": null,
"firstname": "Josh",
"initials": "J",
"lastname": "Kemppainen"
},
{
"affiliation": "Department of Mechanical Engineering-Engineering Mechanics, Michigan Technological University, Houghton, Michigan 49931, United States.",
"collective": null,
"firstname": "Gregory M",
"initials": "GM",
"lastname": "Odegard"
},
{
"affiliation": "Department of Mechanical Engineering and Engineering Science, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, United States.",
"collective": null,
"firstname": "Ozgur",
"initials": "O",
"lastname": "Keles"
}
] |
ACS omega
| null |
40256520
19957928
28088122
20183814
26558557
32877159
31909111
31457728
35012124
38389955
38389955
39261455
29518340
38926930
31806922
38926930
29996044
37027214
|
Optimizing Epoxy Nanocomposites with Oxidized Graphene Quantum Dots for Superior Mechanical Performance: A Molecular Dynamics Approach.
| null | null | null | null | null | null |
null |
Copyright Β© 2023 the Author(s). Published by Wolters Kluwer Health, Inc.
|
10.1097/MD.0000000000036796
| null |
[] |
2024-01-11
|
Cancer with unknown primary site is a kind of disease that is difficult to deal with clinically, accounting for 2% to 9% of all newly diagnosed cancer cases. Here, we report such a case with pelvic metastatic squamous cell carcinoma of an unknown primary site and review the relevant literature.
A 43-year-old Chinese female patient was referred to our hospital and initially diagnosed as "malignant tumor of right adnexal area?, obstruction of right ureter, secondary hydronephrosis".
Thereafter cytoreductive surgery was performed which included a total hysterectomy, left adnexectomy, partial omentum resection, pelvic lymph node dissection, and para-aortic lymph node dissection. The primary lesion could not be identified by supplementary examination and postoperative pathology. The patient was diagnosed as pelvic metastatic squamous cell carcinoma whose primary site was unknown. To prevent a recurrence, we administered adjuvant chemotherapy for the patient.
The patient was followed up after treatment, complete remission has been maintained for 72 months, and no recurrence or metastasis has been found.
Our case demonstrates that surgery combined with chemotherapy could be helpful for pelvic metastatic squamous cell carcinoma of unknown primary site.
|
[
{
"affiliation": "Department of Gynecological Oncology, Jiangxi Maternal and Child Health Hospital, Nanchang, Jiangxi, People's Republic of China.",
"collective": null,
"firstname": "Qi-Zhou",
"initials": "QZ",
"lastname": "Zhu"
},
{
"affiliation": "Medical Department, Jiangxi Maternal and Child Health Hospital, Nanchang, Jiangxi, People's Republic of China.",
"collective": null,
"firstname": "Hui-Juan",
"initials": "HJ",
"lastname": "Li"
},
{
"affiliation": "Department of Gynecological Oncology, Jiangxi Maternal and Child Health Hospital, Nanchang, Jiangxi, People's Republic of China.",
"collective": null,
"firstname": "Yuan-Qiang",
"initials": "YQ",
"lastname": "Li"
},
{
"affiliation": "Department of Pathology, Jiangxi Maternal and Child Health Hospital, Nanchang, Jiangxi, People's Republic of China.",
"collective": null,
"firstname": "Xiao-Hong",
"initials": "XH",
"lastname": "Yu"
},
{
"affiliation": "Department of Gynecological Oncology, Jiangxi Maternal and Child Health Hospital, Nanchang, Jiangxi, People's Republic of China.",
"collective": null,
"firstname": "Kuan-Yong",
"initials": "KY",
"lastname": "Shu"
}
] |
Medicine
| null |
38206704
|
Pelvic metastatic squamous cell carcinoma of unknown primary site: A case report and brief literature review.
| null | null | null | null | null | null |
Early PPV was superior to initial intravitreal antibiotics alone as it required fewer additional treatments to control infection. Visual outcome was similar between early PPV and initial intravitreal antibiotics alone despite high number of poor presenting VA of light-perception in early PPV group. Streptococcal infection and retinal detachment were major poor prognostic factors for vision.
|
Β© 2022. The Author(s), under exclusive licence to The Royal College of Ophthalmologists.
|
10.1038/s41433-022-02347-1
10.1136/bjo.2008.147520
10.1016/j.jcrs.2011.06.019
10.1016/j.ophtha.2016.02.019
10.1007/s10384-017-0545-6
10.3349/ymj.2019.60.5.467
10.1016/j.ophtha.2019.08.026
10.1007/s00417-005-0082-8
10.1038/sj.eye.6702987
10.1007/s00417-012-1926-7
10.1016/j.jcma.2017.05.001
10.1097/ICU.0000000000000727
10.1016/j.survophthal.2018.02.003
10.1001/archopht.1995.01100120009001
10.1136/bmjophth-2019-000423
10.1097/IAE.0b013e3181953a31
10.1097/IAE.0000000000002856
10.1111/ceo.13077
10.1016/j.ophtha.2005.01.050
10.1001/jamaophthalmol.2013.4242
10.1016/S0002-9394(14)71959-2
10.1016/j.ophtha.2007.06.006
10.1016/j.jcrs.2006.10.022
10.1016/j.jcrs.2012.10.037
10.1016/j.ajo.2016.11.006
10.1016/j.ajo.2013.12.026
10.1001/archopht.118.12.1661
10.1136/bjophthalmol-2015-307359
|
Out of 41,411 cataract operations, 22 eyes developed acute postoperative endophthalmitis. Presenting VA was hand-movement or worse in 72.7%. The most common organisms were Staphylococcus (40.9%), Streptococcus (13.6%) and Enterococcus (13.6%). 22.7% of eyes had good final VAββ₯β20/30 and 27.3% had poor final VAβ<β20/400. Early PPV group had significantly lower rate of requiring additional treatments to control infection (25% versus 80%, Pβ=β0.030), higher rate of retinal detachment (25% versus 0%, Pβ=β0.221) and similar final logMAR VA (1.08βΒ±β1.08 versus 0.80βΒ±β0.80, Pβ=β0.489) compared to IVA. Multivariate linear regression analysis showed that worse final VA was significantly associated with Streptococcus (Γβ=β1.92, Pβ=β0.007) and retinal detachment (Γβ=β1.72, Pβ=β0.005) but not with early PPV (Pβ=β0.225).
|
[] |
2022-12-14
|
To evaluate result of early pars plana vitrectomy (PPV) within 24βhours of presentation for acute postoperative endophthalmitis after cataract operation, and to determine factors that predict visual outcome.
Consecutive patients who developed acute postoperative endophthalmitis within 6 weeks after cataract operation were reviewed. Patients were divided into two groups for analysis: (1) those receiving PPV within 24βhours of presentation (early PPV group), and (2) those receiving initial intravitreal antibiotics only without PPV within 24βhours of presentation (IVA group).
Out of 41,411 cataract operations, 22 eyes developed acute postoperative endophthalmitis. Presenting VA was hand-movement or worse in 72.7%. The most common organisms were Staphylococcus (40.9%), Streptococcus (13.6%) and Enterococcus (13.6%). 22.7% of eyes had good final VAββ₯β20/30 and 27.3% had poor final VAβ<β20/400. Early PPV group had significantly lower rate of requiring additional treatments to control infection (25% versus 80%, Pβ=β0.030), higher rate of retinal detachment (25% versus 0%, Pβ=β0.221) and similar final logMAR VA (1.08βΒ±β1.08 versus 0.80βΒ±β0.80, Pβ=β0.489) compared to IVA. Multivariate linear regression analysis showed that worse final VA was significantly associated with Streptococcus (Γβ=β1.92, Pβ=β0.007) and retinal detachment (Γβ=β1.72, Pβ=β0.005) but not with early PPV (Pβ=β0.225).
Early PPV was superior to initial intravitreal antibiotics alone as it required fewer additional treatments to control infection. Visual outcome was similar between early PPV and initial intravitreal antibiotics alone despite high number of poor presenting VA of light-perception in early PPV group. Streptococcal infection and retinal detachment were major poor prognostic factors for vision.
|
[
{
"affiliation": "Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong, China. [email protected].\nDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China. [email protected].",
"collective": null,
"firstname": "Lawrence Pui Leung",
"initials": "LPL",
"lastname": "Iu"
},
{
"affiliation": "Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong, China.\nDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.",
"collective": null,
"firstname": "Ho Yan",
"initials": "HY",
"lastname": "Chan"
},
{
"affiliation": "Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong, China.\nDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.",
"collective": null,
"firstname": "Gabriel Ka Hin",
"initials": "GKH",
"lastname": "Li"
},
{
"affiliation": "Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong, China.\nDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.",
"collective": null,
"firstname": "Mary",
"initials": "M",
"lastname": "Ho"
},
{
"affiliation": "Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong, China.\nDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.",
"collective": null,
"firstname": "Andrew Chun Yue",
"initials": "ACY",
"lastname": "Mak"
},
{
"affiliation": "Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong, China.\nDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.",
"collective": null,
"firstname": "Posey Po Yin",
"initials": "PPY",
"lastname": "Wong"
},
{
"affiliation": "Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong, China.\nDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.",
"collective": null,
"firstname": "Ka Wai",
"initials": "KW",
"lastname": "Kam"
},
{
"affiliation": "Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.",
"collective": null,
"firstname": "Li Jia",
"initials": "LJ",
"lastname": "Chen"
},
{
"affiliation": "Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.",
"collective": null,
"firstname": "Marten",
"initials": "M",
"lastname": "Brelen"
},
{
"affiliation": "Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong, China.\nDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.",
"collective": null,
"firstname": "Alvin Lerrmann",
"initials": "AL",
"lastname": "Young"
}
] |
Eye (London, England)
| null |
36513854
|
Acute postoperative endophthalmitis after cataract operation: result of early vitrectomy within 24βhours of presentation.
| null | null | null | null | null | null |
null |
Copyright by International Society of Lymphology.
| null | null |
[
"Noonan syndrome",
"RIT1",
"indocyanine green lymphography",
"lymphatic malformation",
"lymphedema",
"lymphoscintigraphy",
"magnetic resonance lymphangiography"
] |
2020-11-16
|
L ymphedema is a well-known complication of Noonan syndrome (NS) but the lymphatic malformations in NS are poorly understood. We report clinical, genetic, and imaging information about a boy and girl with NS and late-onset lower extremity lymphedema. A de novo missense mutation of RIT1 (NM_006912.5) c.246T>A, p.Phe82Leu was identified in the girl, who also showed systemic lymphatic hyperplasia and dysfunction. Magnetic resonance lymphangiography (MRL) of the boy clearly demonstrated segmental dilated and hyperplastic lymphatics with impaired transport function in an affected limb and pelvic region. Indocyanine green lymphography (ICGL) showed delayed and partial enhancement of the lymph vessels in the affected limb but no lymph reflux was detected. No causative mutation was identified in the second case. Lymphoscintigraphy (LSG) failed to show lymph vessels in either of the children. Our study showed that MRL is a reliable and accurate test that can be used to demonstrate morpho-logical and functional defects of the lymphatic system. Moreover, ICGL is sufficiently sensitive to determine the functional condition of peripheral lymph vessels. The combined use of imaging modalities can give an accurate diagnosis of complex lymphatic system anomalies in NS and other syndromic diseases.
|
[
{
"affiliation": "Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.",
"collective": null,
"firstname": "N-F",
"initials": "NF",
"lastname": "Liu"
},
{
"affiliation": "Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.",
"collective": null,
"firstname": "M-Z",
"initials": "MZ",
"lastname": "Gao"
}
] |
Lymphology
| null |
33190430
|
Lymphatic system malformations in Noonan syndrome: Two case reports and imaging analysis.
| null | null | null | null | null | null |
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