JerrySiRi/SWN_Bert_based_2019_2023_15000 · Datasets at Hugging Face

pmid int64 26.1M 38.1M	pubdate int64 2.02k 2.02k	software listlengths 0 25
36,936,078	2,023	[]
37,217,230	2,023	[]
37,082,278	2,023	[]
37,493,304	2,023	[]
37,795,641	2,023	[]
37,116,250	2,023	[]
37,475,788	2,023	[]
37,665,350	2,023	[]
36,874,458	2,023	[ { "contexts": [ "Microcytic hypochromic Anemia is a risk factor for postoperative HAEC: A retrospective study.Background\n", "Hirschsprung-associated enterocolitis (HAEC) is a common and life-threatening complication of Hirschsprung's disease (HSCR), which can occur before and after surgery. ", "The aim of this study was to identify the risk factors associated with the development of HAEC.\n\n\n", "We retrospectively reviewed the medical records of HSCR patients admitted to the Children's Hospital of Shanxi Province, China, between January 2011 and August 2021. ", "Diagnosis of HAEC was made using a scoring system with cutoff values ≥4 and included the patient's history, physical examination, and radiological and laboratory findings. ", "The results are shown as frequency (%). ", "The chi-square test was used to analyze a single factor with a significance level of P < 0.05. ", "Logistic regression analysis was used to analyze multiple factors.\n\n\n", "A total of 324 patients were included in this study, with 266 males and 58 females. ", "In total, 34.3% (111/324) of patients had HAEC, including 85 males and 26 females; 18.9% (61/324) of patients had preoperative HAEC; and 15.4% (50/324) of patients had postoperative HAEC within one year after surgery. ", "Gender, age at definitive therapy, and feeding methods were not found to be associated with preoperative HAEC in univariate analysis. ", "Respiratory infection was associated with preoperative HAEC (P = 0.00003). ", "No association was found between gender and age at definitive therapy and postoperative HAEC. ", "Postoperative HAEC was associated with microcytic hypochromic anemia (P = 0.00058), preoperative history of HAEC (P = 0.00120), the creation of a preoperative stoma (P = 0.00097), long segment or total colon HSCR (P = 0.00057), and hypoalbuminemia (P = 0.03225). ", "Regression analysis showed that microcytic hypochromic anemia (OR=2.716, 95% CI = 1.418-5.203, P = 0.003), preoperative history of HAEC (OR=2.814, 95% CI = 1.429-5.542, P = 0.003), the creation of a preoperative stoma (OR=2.332, 95% CI = 1.003-5.420, P = 0.049), and long segment or total colon HSCR (OR=2.167, 95% CI = 1.054-4.456, P = 0.035) were associated with postoperative HAEC.\n\n\n", "Conclusion\n", "This study revealed that the incidence of preoperative HAEC at our hospital was associated with respiratory infections. ", "In addition, microcytic hypochromic anemia, preoperative history of HAEC, the creation of a preoperative stoma, and long segment or total colon HSCR were risk factors of postoperative HAEC. ", "The most important finding of this study was that microcytic hypochromic anemia was a risk factor for postoperative HAEC, which has been rarely reported. ", "Further studies with larger sample sizes are necessary to confirm these findings." ], "name": "C" } ]
37,643,305	2,023	[ { "contexts": [ "After controlling for demographic and pandemic experience factors, symptoms of traumatic stress, but not other mental health outcomes, were associated with less intention to vaccinate. " ], "name": "THERM" } ]
37,398,519	2,023	[]
36,770,084	2,023	[]
36,668,677	2,023	[]
37,278,136	2,023	[]
37,670,287	2,023	[ { "contexts": [ "Cardiovascular disease and all-cause mortality associated with individual and combined cardiometabolic risk factors.BACKGROUND\n", "Previous studies have investigated the association between cardiometabolic risk factors and cardiovascular disease (CVD), but evidence of the attributable burden of individual and combined cardiometabolic risk factors for CVD and mortality is limited. ", "We aimed to investigate and quantify the associations and population attributable fraction (PAF) of cardiometabolic risk factors on CVD and all-cause mortality, and calculate the loss of CVD-free years and years of life lost in relation to the presence of cardiometabolic risk factors.\n\n\n", "Twenty-two thousand five hundred ninety-six participants aged ≥ 35 without CVD at baseline were included between October 2012 and December 2015. ", "The outcomes were the composite of fatal and nonfatal CVD events and all-cause mortality, which were followed up in 2018 and 2019 and ascertained by hospital records and death certificates. ", "Cox regression was applied to evaluate the association of individual and combined cardiometabolic risk factors (including hypertension, diabetes and high low-density lipoprotein cholesterol (LDL-C)) with CVD risk and all-cause mortality. ", "We also described the PAF for CVD and reductions in CVD-free years and life expectancy associated with different combination of cardiometabolic conditions.\n\n\n", "RESULTS\n", "During the 4.92 years of follow-up, we detected 991 CVD events and 1126 deaths. ", "Hazard ratio were 1.59 (95% confidential interval (CI) 1.37-1.85), 1.82 (95%CI 1.49-2.24) and 2.97 (95%CI 1.85-4.75) for CVD and 1.38 (95%CI 1.20-1.58), 1.66 (95%CI 1.37-2.02) and 2.97 (95%CI 1.88-4.69) for all-cause mortality, respectively, in participants with one, two or three cardiometabolic risk factors compared with participants without diabetes, hypertension, and high LDL-C. ", "21.48% of CVD and 15.38% of all-cause mortality were attributable to the combined effect of diabetes and hypertension. ", "Participants aged between 40 and 60 years old, with three cardiometabolic disorders, had approximately 4.3-year reductions life expectancy compared with participants without any abnormalities of cardiometabolic disorders.\n\n\n", "Cardiometabolic risk factors were associated with a multiplicative risk of CVD incidence and all-cause mortality, highlighting the importance of comprehensive management for hypertension, diabetes and dyslipidemia in the prevention of CVD." ], "name": "R" } ]
37,403,923	2,023	[]
37,899,128	2,023	[]
36,754,982	2,023	[]
37,440,632	2,023	[ { "contexts": [ "Multiplex CRISPR editing of wood for sustainable fiber production.The domestication of forest trees for a more sustainable fiber bioeconomy has long been hindered by the complexity and plasticity of lignin, a biopolymer in wood that is recalcitrant to chemical and enzymatic degradation. ", "Here, we show that multiplex CRISPR editing enables precise woody feedstock design for combinatorial improvement of lignin composition and wood properties. ", "CRISPR editing increased the wood carbohydrate-to-lignin ratio up to 228% that of wild type, leading to more-efficient fiber pulping. " ], "name": "CRISPR" }, { "contexts": [ "Multiplex CRISPR editing of wood for sustainable fiber production.The domestication of forest trees for a more sustainable fiber bioeconomy has long been hindered by the complexity and plasticity of lignin, a biopolymer in wood that is recalcitrant to chemical and enzymatic degradation. ", "Here, we show that multiplex CRISPR editing enables precise woody feedstock design for combinatorial improvement of lignin composition and wood properties. ", "CRISPR editing increased the wood carbohydrate-to-lignin ratio up to 228% that of wild type, leading to more-efficient fiber pulping. " ], "name": "CRISPR" } ]
37,792,538	2,023	[]
37,623,381	2,023	[]
37,176,354	2,023	[]
36,738,227	2,023	[]
36,843,031	2,023	[]
37,462,429	2,023	[]
37,402,022	2,023	[]
36,848,551	2,023	[]
37,688,245	2,023	[]
37,127,368	2,023	[]
37,448,478	2,023	[ { "contexts": [ "Recent evidence from humans and other mammals suggests that sugar-rich diets of floral nectar and ripe fruit have favoured mutations in, and functional preservation of, the ADH7 gene, which encodes the ADH class 4 enzyme responsible for metabolizing ethanol. " ], "name": "THERM" } ]
38,014,162	2,023	[]
37,424,357	2,023	[]
36,877,401	2,023	[]
37,276,625	2,023	[ { "contexts": [ "Furthermore, from 2000 to 2005, ten new urban areas have been established. " ], "name": "THERM" } ]
37,076,902	2,023	[]
37,378,148	2,023	[]
36,702,854	2,023	[]
37,886,669	2,023	[]
37,934,367	2,023	[ { "contexts": [ "Furthermore, a differential gene expression analysis was performed using qRT-PCR on four genes such as Phloem Intercalated with Xylem (PXY), Clavata3/Embryo Surrounding Region-Related 41 (CLE41), 1-aminocyclopropane-1-carboxylic acid synthase (ACS-1) and Hemoglobin1 (Hb1) for downstream analysis. " ], "name": "THERM" } ]
37,708,692	2,023	[]
37,741,466	2,023	[ { "contexts": [ "We used latent growth curve modeling to examine whether mothers' and fathers' anxiety and depression, measured in two ways - as diagnostic status and symptom severity - serve as unique predictors of developmental shifts in infant temperament from 3 to 12 months. " ], "name": "THERM" } ]
37,370,710	2,023	[]
38,029,100	2,023	[ { "contexts": [ "We utilized Hidden Markov Models from the Pfam database to retrieve regulatory elements, such as histidine kinases and transcription factors, from BGCs in the MIBiG database, focusing on actinobacterial strains from three distinct environments: oligotrophic basins, rainforests, and marine environments. " ], "name": "Pfam" }, { "contexts": [ "We utilized Hidden Markov Models from the Pfam database to retrieve regulatory elements, such as histidine kinases and transcription factors, from BGCs in the MIBiG database, focusing on actinobacterial strains from three distinct environments: oligotrophic basins, rainforests, and marine environments. " ], "name": "MIBiG" } ]
37,193,994	2,023	[]
37,936,577	2,023	[ { "contexts": [ "Results and Discussion: Spectrum analysis showed that MitoView 633 emission could be detected at 660 ± 50 nm, and exhibited superior thermal stability compared to tetramethylrhodamine methyl ester (TMRM), a commonly used DYm indicator, which emits at 605 ± 25 nm. ", "Furthermore, our investigation revealed that MitoView 633 exhibited minimal photobleaching at the recommended in vitro concentrations. " ], "name": "THERM" } ]
36,864,395	2,023	[]
38,002,808	2,023	[]
37,678,596	2,023	[ { "contexts": [ "Furthermore, T-2 toxin was observed to activate ferroptosis, as evidenced by an increase in iron (Fe2+) concentration and upregulation of prostaglandin endoperoxide synthase 2, downregulation of glutathione peroxidase 4 and ferritin heavy chain, as well as ferroptotic morphological alterations. " ], "name": "THERM" } ]
37,198,273	2,023	[]
36,923,777	2,023	[]
37,784,136	2,023	[]
36,963,509	2,023	[]
36,915,979	2,023	[]
37,101,930	2,023	[]
37,961,432	2,023	[]
37,942,009	2,023	[]
36,642,375	2,023	[]
37,498,686	2,023	[]
37,577,360	2,023	[]
37,377,271	2,023	[]
36,763,997	2,023	[]
37,108,310	2,023	[]
36,839,967	2,023	[]
36,776,046	2,023	[]
36,631,124	2,023	[]
36,858,595	2,023	[]
37,668,566	2,023	[]
37,130,660	2,023	[]
37,972,867	2,023	[]
37,836,345	2,023	[]
36,748,895	2,023	[]
37,909,379	2,023	[]
37,580,556	2,023	[ { "contexts": [ "Development and evaluation study of FLY-Kids: a new lifestyle screening tool for young children.Evaluating, discussing, and advising on young children's lifestyles may contribute to timely modification of unhealthy behaviour and prevention of adverse health consequences. ", "The lifestyle screening tool \"FLY-Kids\" was developed using data from lifestyle behaviour patterns of Dutch toddlers, age-specific lifestyle recommendations, target group analyses, and a Delphi process. ", "Through 10 items, FLY-Kids generates a dashboard with an overview of the child's lifestyle that can be used as conversation aid. ", "FLY-Kids was completed by parents of children aged 1-3 years attending a regular youth healthcare appointment. ", "Youth healthcare professionals (YHCP) then used the FLY-Kids dashboard to discuss lifestyle with the parents and provided tailored advice. ", "Descriptive and correlation statistics were used to determine the usability, feasibility, and preliminary effect of FLY-Kids. ", "Parents and YHCP regarded FLY-Kids as usable and feasible. ", "The number of items identified by FLY-Kids as requiring attention was associated with the number of items discussed during the appointment (r = 0.47, p < 0.001). ", "Conclusion: FLY-Kids can be used to identify unhealthy lifestyle behaviour in young children and guide the conversation about lifestyle in preventive healthcare settings. ", "End-users rated FLY-Kids as helpful and user-friendly. ", "What is New: • The new lifestyle screening tool FLY-Kids generates a dashboard with an overview of young children's lifestyle that can be used as conversation aid between parents and youth healthcare professionals. ", "• As parents and youth healthcare professionals rated FLY-Kids as helpful and user-friendly, and the number of items identified by FLY-Kids as requiring attention was associated with the number of items discussed during the appointment, FLY-Kids can be considered guiding the lifestyle discussion in preventive healthcare settings." ], "name": "FLY-Kids" }, { "contexts": [ "Development and evaluation study of FLY-Kids: a new lifestyle screening tool for young children.Evaluating, discussing, and advising on young children's lifestyles may contribute to timely modification of unhealthy behaviour and prevention of adverse health consequences. ", "The lifestyle screening tool \"FLY-Kids\" was developed using data from lifestyle behaviour patterns of Dutch toddlers, age-specific lifestyle recommendations, target group analyses, and a Delphi process. ", "Through 10 items, FLY-Kids generates a dashboard with an overview of the child's lifestyle that can be used as conversation aid. ", "FLY-Kids was completed by parents of children aged 1-3 years attending a regular youth healthcare appointment. ", "Youth healthcare professionals (YHCP) then used the FLY-Kids dashboard to discuss lifestyle with the parents and provided tailored advice. ", "Descriptive and correlation statistics were used to determine the usability, feasibility, and preliminary effect of FLY-Kids. ", "Parents and YHCP regarded FLY-Kids as usable and feasible. ", "The number of items identified by FLY-Kids as requiring attention was associated with the number of items discussed during the appointment (r = 0.47, p < 0.001). ", "Conclusion: FLY-Kids can be used to identify unhealthy lifestyle behaviour in young children and guide the conversation about lifestyle in preventive healthcare settings. ", "End-users rated FLY-Kids as helpful and user-friendly. ", "What is New: • The new lifestyle screening tool FLY-Kids generates a dashboard with an overview of young children's lifestyle that can be used as conversation aid between parents and youth healthcare professionals. ", "• As parents and youth healthcare professionals rated FLY-Kids as helpful and user-friendly, and the number of items identified by FLY-Kids as requiring attention was associated with the number of items discussed during the appointment, FLY-Kids can be considered guiding the lifestyle discussion in preventive healthcare settings." ], "name": "FLY-Kids" }, { "contexts": [ "Development and evaluation study of FLY-Kids: a new lifestyle screening tool for young children.Evaluating, discussing, and advising on young children's lifestyles may contribute to timely modification of unhealthy behaviour and prevention of adverse health consequences. ", "The lifestyle screening tool \"FLY-Kids\" was developed using data from lifestyle behaviour patterns of Dutch toddlers, age-specific lifestyle recommendations, target group analyses, and a Delphi process. ", "Through 10 items, FLY-Kids generates a dashboard with an overview of the child's lifestyle that can be used as conversation aid. ", "FLY-Kids was completed by parents of children aged 1-3 years attending a regular youth healthcare appointment. ", "Youth healthcare professionals (YHCP) then used the FLY-Kids dashboard to discuss lifestyle with the parents and provided tailored advice. ", "Descriptive and correlation statistics were used to determine the usability, feasibility, and preliminary effect of FLY-Kids. ", "Parents and YHCP regarded FLY-Kids as usable and feasible. ", "The number of items identified by FLY-Kids as requiring attention was associated with the number of items discussed during the appointment (r = 0.47, p < 0.001). ", "Conclusion: FLY-Kids can be used to identify unhealthy lifestyle behaviour in young children and guide the conversation about lifestyle in preventive healthcare settings. ", "End-users rated FLY-Kids as helpful and user-friendly. ", "What is New: • The new lifestyle screening tool FLY-Kids generates a dashboard with an overview of young children's lifestyle that can be used as conversation aid between parents and youth healthcare professionals. ", "• As parents and youth healthcare professionals rated FLY-Kids as helpful and user-friendly, and the number of items identified by FLY-Kids as requiring attention was associated with the number of items discussed during the appointment, FLY-Kids can be considered guiding the lifestyle discussion in preventive healthcare settings." ], "name": "FLY-Kids" } ]
37,465,837	2,023	[]
36,760,757	2,023	[]
38,038,351	2,023	[ { "contexts": [ "Further multicenter trials with multiple endoscopists with varying expertise levels and longer-term outcome data showing a reduction in cancer or cancer-related death are needed." ], "name": "THERM" } ]
37,903,782	2,023	[]
37,422,723	2,023	[]
37,769,835	2,023	[]
36,879,531	2,023	[ { "contexts": [ "We use established scales to assess relevant variables and apply the PROCESS 3.5 software of SPSS to construct a chain mediating effect.\n\n\n" ], "name": "PROCESS 3.5 software" } ]
37,394,520	2,023	[]
36,831,902	2,023	[]
36,816,963	2,023	[ { "contexts": [ "Three deep learning models were constructed based on three different delineate methods of the region of interest (ROI) using the Darwin Scientific Research Platform (Beijing Yizhun Intelligent Technology Co., Ltd., China). " ], "name": "Darwin Scientific Research Platform" } ]
37,972,928	2,023	[]
37,860,083	2,023	[]
37,574,638	2,023	[ { "contexts": [ "Furthermore, OSP aligns with a growing national interest in the use of natural infrastructure for flood protection. " ], "name": "THERM" } ]
36,723,096	2,023	[]
37,667,843	2,023	[]
37,511,623	2,023	[]
36,804,504	2,023	[]
37,038,130	2,023	[ { "contexts": [ "Imaging of five anonymous excised human cadaver temporal bones, the acquisition of the effective doses and the CNR measurements were performed for images acquired on using Planmed XFI® full body CBCT device (Planmed Oy, Helsinki, Finland) with a voxel size of 75 µm. ", "In this ex vivo experiment, the new Planmed XFI® full body CBCT device produced excellent 2D resolution and easily created 3D reconstructions in middle ear imaging with moderate effective doses. " ], "name": "Planmed XFI" }, { "contexts": [ "Imaging of five anonymous excised human cadaver temporal bones, the acquisition of the effective doses and the CNR measurements were performed for images acquired on using Planmed XFI® full body CBCT device (Planmed Oy, Helsinki, Finland) with a voxel size of 75 µm. " ], "name": "Planmed Oy" }, { "contexts": [ "Imaging of five anonymous excised human cadaver temporal bones, the acquisition of the effective doses and the CNR measurements were performed for images acquired on using Planmed XFI® full body CBCT device (Planmed Oy, Helsinki, Finland) with a voxel size of 75 µm. " ], "name": "Helsinki" }, { "contexts": [ "Imaging of five anonymous excised human cadaver temporal bones, the acquisition of the effective doses and the CNR measurements were performed for images acquired on using Planmed XFI® full body CBCT device (Planmed Oy, Helsinki, Finland) with a voxel size of 75 µm. " ], "name": "Finland" } ]
36,755,568	2,023	[ { "contexts": [ "Clinical information on lncRNAs associated with differences in cuproptosis genes in ccRCC and normal tissues was collected from The Cancer Genome Atlas (TCGA) dataset. " ], "name": "The Cancer Genome Atlas" } ]
37,231,142	2,023	[]
37,024,849	2,023	[]
37,969,817	2,023	[]
37,269,249	2,023	[]
37,665,049	2,023	[ { "contexts": [ "Prior elicitation for Gaussian spatial process: An application to TMS brain mapping.The power and commensurate prior distributions are informative prior distributions that incorporate historical data as prior knowledge in Bayesian analysis to improve inference about a phenomenon under study. ", "Hierarchical models combined with the developed informative prior distributions were applied to analyze transcranial magnetic stimulation (TMS) brain mapping data to gain insights into the spatial pattern of a patient's response to motor cortex stimulation. " ], "name": "TMS" }, { "contexts": [ "Prior elicitation for Gaussian spatial process: An application to TMS brain mapping.The power and commensurate prior distributions are informative prior distributions that incorporate historical data as prior knowledge in Bayesian analysis to improve inference about a phenomenon under study. ", "In this study, we extend these informative prior distributions to a Gaussian spatial process, which enables the elicitation of prior knowledge from historical geostatistical data for Bayesian analysis. ", "Three informative prior distributions were developed for spatial modeling, and an efficient Markov Chain Monte Carlo algorithm was developed for performing Bayesian analysis. " ], "name": "Bayesian analysis" }, { "contexts": [ "Three informative prior distributions were developed for spatial modeling, and an efficient Markov Chain Monte Carlo algorithm was developed for performing Bayesian analysis. " ], "name": "Markov Chain Monte Carlo algorithm" } ]
36,681,097	2,023	[]
36,653,090	2,023	[]
37,278,107	2,023	[ { "contexts": [ "Serum NLRP1 and cancer biomarkers of CEA and CYFRA21-1 were then measured using enzyme-linked immunosorbent assay (ELISA). ", "Lower NLRP1 level is associated with worse clinical outcomes and poorer prognosis in cSCC and cBCC patients." ], "name": "ELISA" }, { "contexts": [ "Low-level NLRP1 is associated with increased metastasis and risk of recurrence of non-melanoma skin cancer.BACKGROUND\n", "Cutaneous squamous cell carcinoma (cSCC) and cutaneous basal cell carcinoma (cBCC) are the most common types of non-melanoma skin cancer (NMSC). ", "The NACHT, LRR and PYD domains-containing protein 1 (NLRP1) protein is considered to be inhibited in NMSC, although clinical evidence is still lacking.\n\n\n", "OBJECTIVES\n", "To investigate the clinical significance of NLRP1 in cSCC and cBCC patients.\n\n\n", "This prospective observational study enrolled 199 cases of cBCC and cSCC patients who reported to our hospital from January 2018 to January 2019. ", "Additionally, 199 blood samples from healthy individuals were collected as the control. ", "Serum NLRP1 and cancer biomarkers of CEA and CYFRA21-1 were then measured using enzyme-linked immunosorbent assay (ELISA). ", "Clinical characteristics collected from patients included age, sex, BMI, TNM stage, cancer type, lymph node metastasis, and myometrial infiltration conditions. ", "Serum NLRP1 showed markedly lower levels in cancer patients compared with healthy controls. ", "Furthermore, the expression of NLRP1 was significantly higher in cBCC patients compared with cSCC patients. ", "The deceased patients, together with those with lymph node metastasis and myometrial infiltration, also showed significantly lower NLRP1 levels. ", "Moreover, lower NLRP1 levels were associated with higher frequencies of tumor-nodule-metastasis (TNM) III-IV stage, lymph node metastasis and myometrial infiltration, as well as higher mortality and recurrence rates. ", "The curvilinear regression showed the relationship between NLRP1 and CEA/or CYFRA21-1 was most appropriate for the reciprocal. ", "Receiver operating characteristic (ROC) curves showed NLRP1 was a potential biomarker for lymph node metastasis, myometrial infiltration and prognosis in NMSC patients, and the Kaplan-Meier analysis found NLRP1 was associated with 1-3-year mortality and recurrence of NMSC.\n\n\n", "CONCLUSIONS\n", "Lower NLRP1 level is associated with worse clinical outcomes and poorer prognosis in cSCC and cBCC patients." ], "name": "C" } ]

36,936,078

2,023

[]

37,217,230

2,023

[]

37,082,278

2,023

[]

37,493,304

2,023

[]

37,795,641

2,023

[]

37,116,250

2,023

[]

37,475,788

2,023

[]

37,665,350

2,023

[]

36,874,458

2,023

[ { "contexts": [ "Microcytic hypochromic Anemia is a risk factor for postoperative HAEC: A retrospective study.Background\n", "Hirschsprung-associated enterocolitis (HAEC) is a common and life-threatening complication of Hirschsprung's disease (HSCR), which can occur before and after surgery. ", "The aim of this study was to identify the risk factors associated with the development of HAEC.\n\n\n", "We retrospectively reviewed the medical records of HSCR patients admitted to the Children's Hospital of Shanxi Province, China, between January 2011 and August 2021. ", "Diagnosis of HAEC was made using a scoring system with cutoff values ≥4 and included the patient's history, physical examination, and radiological and laboratory findings. ", "The results are shown as frequency (%). ", "The chi-square test was used to analyze a single factor with a significance level of P < 0.05. ", "Logistic regression analysis was used to analyze multiple factors.\n\n\n", "A total of 324 patients were included in this study, with 266 males and 58 females. ", "In total, 34.3% (111/324) of patients had HAEC, including 85 males and 26 females; 18.9% (61/324) of patients had preoperative HAEC; and 15.4% (50/324) of patients had postoperative HAEC within one year after surgery. ", "Gender, age at definitive therapy, and feeding methods were not found to be associated with preoperative HAEC in univariate analysis. ", "Respiratory infection was associated with preoperative HAEC (P = 0.00003). ", "No association was found between gender and age at definitive therapy and postoperative HAEC. ", "Postoperative HAEC was associated with microcytic hypochromic anemia (P = 0.00058), preoperative history of HAEC (P = 0.00120), the creation of a preoperative stoma (P = 0.00097), long segment or total colon HSCR (P = 0.00057), and hypoalbuminemia (P = 0.03225). ", "Regression analysis showed that microcytic hypochromic anemia (OR=2.716, 95% CI = 1.418-5.203, P = 0.003), preoperative history of HAEC (OR=2.814, 95% CI = 1.429-5.542, P = 0.003), the creation of a preoperative stoma (OR=2.332, 95% CI = 1.003-5.420, P = 0.049), and long segment or total colon HSCR (OR=2.167, 95% CI = 1.054-4.456, P = 0.035) were associated with postoperative HAEC.\n\n\n", "Conclusion\n", "This study revealed that the incidence of preoperative HAEC at our hospital was associated with respiratory infections. ", "In addition, microcytic hypochromic anemia, preoperative history of HAEC, the creation of a preoperative stoma, and long segment or total colon HSCR were risk factors of postoperative HAEC. ", "The most important finding of this study was that microcytic hypochromic anemia was a risk factor for postoperative HAEC, which has been rarely reported. ", "Further studies with larger sample sizes are necessary to confirm these findings." ], "name": "C" } ]

37,643,305

2,023

[ { "contexts": [ "After controlling for demographic and pandemic experience factors, symptoms of traumatic stress, but not other mental health outcomes, were associated with less intention to vaccinate. " ], "name": "THERM" } ]

37,398,519

2,023

[]

36,770,084

2,023

[]

36,668,677

2,023

[]

37,278,136

2,023

[]

37,670,287

2,023

[ { "contexts": [ "Cardiovascular disease and all-cause mortality associated with individual and combined cardiometabolic risk factors.BACKGROUND\n", "Previous studies have investigated the association between cardiometabolic risk factors and cardiovascular disease (CVD), but evidence of the attributable burden of individual and combined cardiometabolic risk factors for CVD and mortality is limited. ", "We aimed to investigate and quantify the associations and population attributable fraction (PAF) of cardiometabolic risk factors on CVD and all-cause mortality, and calculate the loss of CVD-free years and years of life lost in relation to the presence of cardiometabolic risk factors.\n\n\n", "Twenty-two thousand five hundred ninety-six participants aged ≥ 35 without CVD at baseline were included between October 2012 and December 2015. ", "The outcomes were the composite of fatal and nonfatal CVD events and all-cause mortality, which were followed up in 2018 and 2019 and ascertained by hospital records and death certificates. ", "Cox regression was applied to evaluate the association of individual and combined cardiometabolic risk factors (including hypertension, diabetes and high low-density lipoprotein cholesterol (LDL-C)) with CVD risk and all-cause mortality. ", "We also described the PAF for CVD and reductions in CVD-free years and life expectancy associated with different combination of cardiometabolic conditions.\n\n\n", "RESULTS\n", "During the 4.92 years of follow-up, we detected 991 CVD events and 1126 deaths. ", "Hazard ratio were 1.59 (95% confidential interval (CI) 1.37-1.85), 1.82 (95%CI 1.49-2.24) and 2.97 (95%CI 1.85-4.75) for CVD and 1.38 (95%CI 1.20-1.58), 1.66 (95%CI 1.37-2.02) and 2.97 (95%CI 1.88-4.69) for all-cause mortality, respectively, in participants with one, two or three cardiometabolic risk factors compared with participants without diabetes, hypertension, and high LDL-C. ", "21.48% of CVD and 15.38% of all-cause mortality were attributable to the combined effect of diabetes and hypertension. ", "Participants aged between 40 and 60 years old, with three cardiometabolic disorders, had approximately 4.3-year reductions life expectancy compared with participants without any abnormalities of cardiometabolic disorders.\n\n\n", "Cardiometabolic risk factors were associated with a multiplicative risk of CVD incidence and all-cause mortality, highlighting the importance of comprehensive management for hypertension, diabetes and dyslipidemia in the prevention of CVD." ], "name": "R" } ]

37,403,923

2,023

[]

37,899,128

2,023

[]

36,754,982

2,023

[]

37,440,632

2,023

[ { "contexts": [ "Multiplex CRISPR editing of wood for sustainable fiber production.The domestication of forest trees for a more sustainable fiber bioeconomy has long been hindered by the complexity and plasticity of lignin, a biopolymer in wood that is recalcitrant to chemical and enzymatic degradation. ", "Here, we show that multiplex CRISPR editing enables precise woody feedstock design for combinatorial improvement of lignin composition and wood properties. ", "CRISPR editing increased the wood carbohydrate-to-lignin ratio up to 228% that of wild type, leading to more-efficient fiber pulping. " ], "name": "CRISPR" }, { "contexts": [ "Multiplex CRISPR editing of wood for sustainable fiber production.The domestication of forest trees for a more sustainable fiber bioeconomy has long been hindered by the complexity and plasticity of lignin, a biopolymer in wood that is recalcitrant to chemical and enzymatic degradation. ", "Here, we show that multiplex CRISPR editing enables precise woody feedstock design for combinatorial improvement of lignin composition and wood properties. ", "CRISPR editing increased the wood carbohydrate-to-lignin ratio up to 228% that of wild type, leading to more-efficient fiber pulping. " ], "name": "CRISPR" } ]

37,792,538

2,023

[]

37,623,381

2,023

[]

37,176,354

2,023

[]

36,738,227

2,023

[]

36,843,031

2,023

[]

37,462,429

2,023

[]

37,402,022

2,023

[]

36,848,551

2,023

[]

37,688,245

2,023

[]

37,127,368

2,023

[]

37,448,478

2,023

[ { "contexts": [ "Recent evidence from humans and other mammals suggests that sugar-rich diets of floral nectar and ripe fruit have favoured mutations in, and functional preservation of, the ADH7 gene, which encodes the ADH class 4 enzyme responsible for metabolizing ethanol. " ], "name": "THERM" } ]

38,014,162

2,023

[]

37,424,357

2,023

[]

36,877,401

2,023

[]

37,276,625

2,023

[ { "contexts": [ "Furthermore, from 2000 to 2005, ten new urban areas have been established. " ], "name": "THERM" } ]

37,076,902

2,023

[]

37,378,148

2,023

[]

36,702,854

2,023

[]

37,886,669

2,023

[]

37,934,367

2,023

[ { "contexts": [ "Furthermore, a differential gene expression analysis was performed using qRT-PCR on four genes such as Phloem Intercalated with Xylem (PXY), Clavata3/Embryo Surrounding Region-Related 41 (CLE41), 1-aminocyclopropane-1-carboxylic acid synthase (ACS-1) and Hemoglobin1 (Hb1) for downstream analysis. " ], "name": "THERM" } ]

37,708,692

2,023

[]

37,741,466

2,023

[ { "contexts": [ "We used latent growth curve modeling to examine whether mothers' and fathers' anxiety and depression, measured in two ways - as diagnostic status and symptom severity - serve as unique predictors of developmental shifts in infant temperament from 3 to 12 months. " ], "name": "THERM" } ]

37,370,710

2,023

[]

38,029,100

2,023

[ { "contexts": [ "We utilized Hidden Markov Models from the Pfam database to retrieve regulatory elements, such as histidine kinases and transcription factors, from BGCs in the MIBiG database, focusing on actinobacterial strains from three distinct environments: oligotrophic basins, rainforests, and marine environments. " ], "name": "Pfam" }, { "contexts": [ "We utilized Hidden Markov Models from the Pfam database to retrieve regulatory elements, such as histidine kinases and transcription factors, from BGCs in the MIBiG database, focusing on actinobacterial strains from three distinct environments: oligotrophic basins, rainforests, and marine environments. " ], "name": "MIBiG" } ]

37,193,994

2,023

[]

37,936,577

2,023

[ { "contexts": [ "Results and Discussion: Spectrum analysis showed that MitoView 633 emission could be detected at 660 ± 50 nm, and exhibited superior thermal stability compared to tetramethylrhodamine methyl ester (TMRM), a commonly used DYm indicator, which emits at 605 ± 25 nm. ", "Furthermore, our investigation revealed that MitoView 633 exhibited minimal photobleaching at the recommended in vitro concentrations. " ], "name": "THERM" } ]

36,864,395

2,023

[]

38,002,808

2,023

[]

37,678,596

2,023

[ { "contexts": [ "Furthermore, T-2 toxin was observed to activate ferroptosis, as evidenced by an increase in iron (Fe2+) concentration and upregulation of prostaglandin endoperoxide synthase 2, downregulation of glutathione peroxidase 4 and ferritin heavy chain, as well as ferroptotic morphological alterations. " ], "name": "THERM" } ]

37,198,273

2,023

[]

36,923,777

2,023

[]

37,784,136

2,023

[]

36,963,509

2,023

[]

36,915,979

2,023

[]

37,101,930

2,023

[]

37,961,432

2,023

[]

37,942,009

2,023

[]

36,642,375

2,023

[]

37,498,686

2,023

[]

37,577,360

2,023

[]

37,377,271

2,023

[]

36,763,997

2,023

[]

37,108,310

2,023

[]

36,839,967

2,023

[]

36,776,046

2,023

[]

36,631,124

2,023

[]

36,858,595

2,023

[]

37,668,566

2,023

[]

37,130,660

2,023

[]

37,972,867

2,023

[]

37,836,345

2,023

[]

36,748,895

2,023

[]

37,909,379

2,023

[]

37,580,556

2,023

[ { "contexts": [ "Development and evaluation study of FLY-Kids: a new lifestyle screening tool for young children.Evaluating, discussing, and advising on young children's lifestyles may contribute to timely modification of unhealthy behaviour and prevention of adverse health consequences. ", "The lifestyle screening tool \"FLY-Kids\" was developed using data from lifestyle behaviour patterns of Dutch toddlers, age-specific lifestyle recommendations, target group analyses, and a Delphi process. ", "Through 10 items, FLY-Kids generates a dashboard with an overview of the child's lifestyle that can be used as conversation aid. ", "FLY-Kids was completed by parents of children aged 1-3 years attending a regular youth healthcare appointment. ", "Youth healthcare professionals (YHCP) then used the FLY-Kids dashboard to discuss lifestyle with the parents and provided tailored advice. ", "Descriptive and correlation statistics were used to determine the usability, feasibility, and preliminary effect of FLY-Kids. ", "Parents and YHCP regarded FLY-Kids as usable and feasible. ", "The number of items identified by FLY-Kids as requiring attention was associated with the number of items discussed during the appointment (r = 0.47, p < 0.001). ", "Conclusion: FLY-Kids can be used to identify unhealthy lifestyle behaviour in young children and guide the conversation about lifestyle in preventive healthcare settings. ", "End-users rated FLY-Kids as helpful and user-friendly. ", "What is New: • The new lifestyle screening tool FLY-Kids generates a dashboard with an overview of young children's lifestyle that can be used as conversation aid between parents and youth healthcare professionals. ", "• As parents and youth healthcare professionals rated FLY-Kids as helpful and user-friendly, and the number of items identified by FLY-Kids as requiring attention was associated with the number of items discussed during the appointment, FLY-Kids can be considered guiding the lifestyle discussion in preventive healthcare settings." ], "name": "FLY-Kids" }, { "contexts": [ "Development and evaluation study of FLY-Kids: a new lifestyle screening tool for young children.Evaluating, discussing, and advising on young children's lifestyles may contribute to timely modification of unhealthy behaviour and prevention of adverse health consequences. ", "The lifestyle screening tool \"FLY-Kids\" was developed using data from lifestyle behaviour patterns of Dutch toddlers, age-specific lifestyle recommendations, target group analyses, and a Delphi process. ", "Through 10 items, FLY-Kids generates a dashboard with an overview of the child's lifestyle that can be used as conversation aid. ", "FLY-Kids was completed by parents of children aged 1-3 years attending a regular youth healthcare appointment. ", "Youth healthcare professionals (YHCP) then used the FLY-Kids dashboard to discuss lifestyle with the parents and provided tailored advice. ", "Descriptive and correlation statistics were used to determine the usability, feasibility, and preliminary effect of FLY-Kids. ", "Parents and YHCP regarded FLY-Kids as usable and feasible. ", "The number of items identified by FLY-Kids as requiring attention was associated with the number of items discussed during the appointment (r = 0.47, p < 0.001). ", "Conclusion: FLY-Kids can be used to identify unhealthy lifestyle behaviour in young children and guide the conversation about lifestyle in preventive healthcare settings. ", "End-users rated FLY-Kids as helpful and user-friendly. ", "What is New: • The new lifestyle screening tool FLY-Kids generates a dashboard with an overview of young children's lifestyle that can be used as conversation aid between parents and youth healthcare professionals. ", "• As parents and youth healthcare professionals rated FLY-Kids as helpful and user-friendly, and the number of items identified by FLY-Kids as requiring attention was associated with the number of items discussed during the appointment, FLY-Kids can be considered guiding the lifestyle discussion in preventive healthcare settings." ], "name": "FLY-Kids" }, { "contexts": [ "Development and evaluation study of FLY-Kids: a new lifestyle screening tool for young children.Evaluating, discussing, and advising on young children's lifestyles may contribute to timely modification of unhealthy behaviour and prevention of adverse health consequences. ", "The lifestyle screening tool \"FLY-Kids\" was developed using data from lifestyle behaviour patterns of Dutch toddlers, age-specific lifestyle recommendations, target group analyses, and a Delphi process. ", "Through 10 items, FLY-Kids generates a dashboard with an overview of the child's lifestyle that can be used as conversation aid. ", "FLY-Kids was completed by parents of children aged 1-3 years attending a regular youth healthcare appointment. ", "Youth healthcare professionals (YHCP) then used the FLY-Kids dashboard to discuss lifestyle with the parents and provided tailored advice. ", "Descriptive and correlation statistics were used to determine the usability, feasibility, and preliminary effect of FLY-Kids. ", "Parents and YHCP regarded FLY-Kids as usable and feasible. ", "The number of items identified by FLY-Kids as requiring attention was associated with the number of items discussed during the appointment (r = 0.47, p < 0.001). ", "Conclusion: FLY-Kids can be used to identify unhealthy lifestyle behaviour in young children and guide the conversation about lifestyle in preventive healthcare settings. ", "End-users rated FLY-Kids as helpful and user-friendly. ", "What is New: • The new lifestyle screening tool FLY-Kids generates a dashboard with an overview of young children's lifestyle that can be used as conversation aid between parents and youth healthcare professionals. ", "• As parents and youth healthcare professionals rated FLY-Kids as helpful and user-friendly, and the number of items identified by FLY-Kids as requiring attention was associated with the number of items discussed during the appointment, FLY-Kids can be considered guiding the lifestyle discussion in preventive healthcare settings." ], "name": "FLY-Kids" } ]

37,465,837

2,023

[]

36,760,757

2,023

[]

38,038,351

2,023

[ { "contexts": [ "Further multicenter trials with multiple endoscopists with varying expertise levels and longer-term outcome data showing a reduction in cancer or cancer-related death are needed." ], "name": "THERM" } ]

37,903,782

2,023

[]

37,422,723

2,023

[]

37,769,835

2,023

[]

36,879,531

2,023

[ { "contexts": [ "We use established scales to assess relevant variables and apply the PROCESS 3.5 software of SPSS to construct a chain mediating effect.\n\n\n" ], "name": "PROCESS 3.5 software" } ]

37,394,520

2,023

[]

36,831,902

2,023

[]

36,816,963

2,023

[ { "contexts": [ "Three deep learning models were constructed based on three different delineate methods of the region of interest (ROI) using the Darwin Scientific Research Platform (Beijing Yizhun Intelligent Technology Co., Ltd., China). " ], "name": "Darwin Scientific Research Platform" } ]

37,972,928

2,023

[]

37,860,083

2,023

[]

37,574,638

2,023

[ { "contexts": [ "Furthermore, OSP aligns with a growing national interest in the use of natural infrastructure for flood protection. " ], "name": "THERM" } ]

36,723,096

2,023

[]

37,667,843

2,023

[]

37,511,623

2,023

[]

36,804,504

2,023

[]

37,038,130

2,023

[ { "contexts": [ "Imaging of five anonymous excised human cadaver temporal bones, the acquisition of the effective doses and the CNR measurements were performed for images acquired on using Planmed XFI® full body CBCT device (Planmed Oy, Helsinki, Finland) with a voxel size of 75 µm. ", "In this ex vivo experiment, the new Planmed XFI® full body CBCT device produced excellent 2D resolution and easily created 3D reconstructions in middle ear imaging with moderate effective doses. " ], "name": "Planmed XFI" }, { "contexts": [ "Imaging of five anonymous excised human cadaver temporal bones, the acquisition of the effective doses and the CNR measurements were performed for images acquired on using Planmed XFI® full body CBCT device (Planmed Oy, Helsinki, Finland) with a voxel size of 75 µm. " ], "name": "Planmed Oy" }, { "contexts": [ "Imaging of five anonymous excised human cadaver temporal bones, the acquisition of the effective doses and the CNR measurements were performed for images acquired on using Planmed XFI® full body CBCT device (Planmed Oy, Helsinki, Finland) with a voxel size of 75 µm. " ], "name": "Helsinki" }, { "contexts": [ "Imaging of five anonymous excised human cadaver temporal bones, the acquisition of the effective doses and the CNR measurements were performed for images acquired on using Planmed XFI® full body CBCT device (Planmed Oy, Helsinki, Finland) with a voxel size of 75 µm. " ], "name": "Finland" } ]

36,755,568

2,023

[ { "contexts": [ "Clinical information on lncRNAs associated with differences in cuproptosis genes in ccRCC and normal tissues was collected from The Cancer Genome Atlas (TCGA) dataset. " ], "name": "The Cancer Genome Atlas" } ]

37,231,142

2,023

[]

37,024,849

2,023

[]

37,969,817

2,023

[]

37,269,249

2,023

[]

37,665,049

2,023

[ { "contexts": [ "Prior elicitation for Gaussian spatial process: An application to TMS brain mapping.The power and commensurate prior distributions are informative prior distributions that incorporate historical data as prior knowledge in Bayesian analysis to improve inference about a phenomenon under study. ", "Hierarchical models combined with the developed informative prior distributions were applied to analyze transcranial magnetic stimulation (TMS) brain mapping data to gain insights into the spatial pattern of a patient's response to motor cortex stimulation. " ], "name": "TMS" }, { "contexts": [ "Prior elicitation for Gaussian spatial process: An application to TMS brain mapping.The power and commensurate prior distributions are informative prior distributions that incorporate historical data as prior knowledge in Bayesian analysis to improve inference about a phenomenon under study. ", "In this study, we extend these informative prior distributions to a Gaussian spatial process, which enables the elicitation of prior knowledge from historical geostatistical data for Bayesian analysis. ", "Three informative prior distributions were developed for spatial modeling, and an efficient Markov Chain Monte Carlo algorithm was developed for performing Bayesian analysis. " ], "name": "Bayesian analysis" }, { "contexts": [ "Three informative prior distributions were developed for spatial modeling, and an efficient Markov Chain Monte Carlo algorithm was developed for performing Bayesian analysis. " ], "name": "Markov Chain Monte Carlo algorithm" } ]

36,681,097

2,023

[]

36,653,090

2,023

[]

37,278,107

2,023

[ { "contexts": [ "Serum NLRP1 and cancer biomarkers of CEA and CYFRA21-1 were then measured using enzyme-linked immunosorbent assay (ELISA). ", "Lower NLRP1 level is associated with worse clinical outcomes and poorer prognosis in cSCC and cBCC patients." ], "name": "ELISA" }, { "contexts": [ "Low-level NLRP1 is associated with increased metastasis and risk of recurrence of non-melanoma skin cancer.BACKGROUND\n", "Cutaneous squamous cell carcinoma (cSCC) and cutaneous basal cell carcinoma (cBCC) are the most common types of non-melanoma skin cancer (NMSC). ", "The NACHT, LRR and PYD domains-containing protein 1 (NLRP1) protein is considered to be inhibited in NMSC, although clinical evidence is still lacking.\n\n\n", "OBJECTIVES\n", "To investigate the clinical significance of NLRP1 in cSCC and cBCC patients.\n\n\n", "This prospective observational study enrolled 199 cases of cBCC and cSCC patients who reported to our hospital from January 2018 to January 2019. ", "Additionally, 199 blood samples from healthy individuals were collected as the control. ", "Serum NLRP1 and cancer biomarkers of CEA and CYFRA21-1 were then measured using enzyme-linked immunosorbent assay (ELISA). ", "Clinical characteristics collected from patients included age, sex, BMI, TNM stage, cancer type, lymph node metastasis, and myometrial infiltration conditions. ", "Serum NLRP1 showed markedly lower levels in cancer patients compared with healthy controls. ", "Furthermore, the expression of NLRP1 was significantly higher in cBCC patients compared with cSCC patients. ", "The deceased patients, together with those with lymph node metastasis and myometrial infiltration, also showed significantly lower NLRP1 levels. ", "Moreover, lower NLRP1 levels were associated with higher frequencies of tumor-nodule-metastasis (TNM) III-IV stage, lymph node metastasis and myometrial infiltration, as well as higher mortality and recurrence rates. ", "The curvilinear regression showed the relationship between NLRP1 and CEA/or CYFRA21-1 was most appropriate for the reciprocal. ", "Receiver operating characteristic (ROC) curves showed NLRP1 was a potential biomarker for lymph node metastasis, myometrial infiltration and prognosis in NMSC patients, and the Kaplan-Meier analysis found NLRP1 was associated with 1-3-year mortality and recurrence of NMSC.\n\n\n", "CONCLUSIONS\n", "Lower NLRP1 level is associated with worse clinical outcomes and poorer prognosis in cSCC and cBCC patients." ], "name": "C" } ]