pmid
int64 26.1M
38.1M
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int64 2.02k
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36,608,043 | 2,023 | [] |
37,719,706 | 2,023 | [
{
"contexts": [
"Furthermore, we identified four genes that play a vital role in lymphocyte development. "
],
"name": "THERM"
},
{
"contexts": [
"Furthermore, we identified four genes that play a vital role in lymphocyte development. "
],
"name": "THERM"
},
{
"contexts": [
"Furthermore, we identified four genes that play a vital role in lymphocyte development. "
],
"name": "THERM"
},
{
"contexts": [
"Furthermore, we identified four genes that play a vital role in lymphocyte development. "
],
"name": "THERM"
}
] |
37,655,764 | 2,023 | [
{
"contexts": [
"Optimizing the architecture of Behler-Parrinello neural network potentials.The architecture of neural network potentials is typically optimized at the beginning of the training process and remains unchanged throughout. ",
"Here, we investigate the accuracy of Behler-Parrinello neural network potentials for varying training set sizes. "
],
"name": "Behler-Parrinello"
},
{
"contexts": [
"Optimizing the architecture of Behler-Parrinello neural network potentials.The architecture of neural network potentials is typically optimized at the beginning of the training process and remains unchanged throughout. ",
"Here, we investigate the accuracy of Behler-Parrinello neural network potentials for varying training set sizes. "
],
"name": "Behler-Parrinello"
}
] |
38,055,462 | 2,023 | [] |
36,922,558 | 2,023 | [] |
37,698,821 | 2,023 | [] |
37,779,107 | 2,023 | [] |
37,379,787 | 2,023 | [] |
37,996,163 | 2,023 | [] |
38,032,382 | 2,023 | [] |
37,274,200 | 2,023 | [] |
37,318,313 | 2,023 | [] |
36,764,820 | 2,023 | [
{
"contexts": [
"Genetically encoded non-canonical amino acids reveal asynchronous dark reversion of chromophore, backbone and side-chains in EL222.Photoreceptors containing the light-oxygen-voltage (LOV) domain elicit biological responses upon excitation of their flavin mononucleotide (FMN) chromophore by blue light. "
],
"name": "Genetically encoded non-canonical amino acids"
},
{
"contexts": [
"Here we incorporated the non-canonical amino acid p-cyanophenylalanine (CNF) by genetic code expansion technology at forty-five positions of the bacterial transcription factor EL222. "
],
"name": "genetic code expansion technology"
},
{
"contexts": [
"Screening of light-induced changes in infrared (IR) absorption frequency, electric field and hydration of the nitrile groups identified residues CNF31 and CNF35 as reporters of monomer/oligomer and caged/decaged equilibria, respectively. "
],
"name": "infrared (IR) absorption frequency"
},
{
"contexts": [
"Screening of light-induced changes in infrared (IR) absorption frequency, electric field and hydration of the nitrile groups identified residues CNF31 and CNF35 as reporters of monomer/oligomer and caged/decaged equilibria, respectively. "
],
"name": "electric field and hydration of the nitrile groups"
},
{
"contexts": [
"Time-resolved multi-probe UV/Visible and IR spectroscopy experiments of the lit-to-dark transition revealed four dynamical events. "
],
"name": "UV/Visible and IR spectroscopy experiments"
}
] |
36,743,785 | 2,023 | [] |
36,810,803 | 2,023 | [] |
36,695,213 | 2,023 | [] |
37,480,523 | 2,023 | [] |
37,161,759 | 2,023 | [] |
37,366,756 | 2,023 | [] |
36,840,811 | 2,023 | [] |
37,882,223 | 2,023 | [] |
37,378,979 | 2,023 | [] |
37,100,289 | 2,023 | [] |
37,492,972 | 2,023 | [] |
36,640,586 | 2,023 | [] |
37,097,836 | 2,023 | [] |
37,331,163 | 2,023 | [] |
37,426,794 | 2,023 | [] |
37,090,602 | 2,023 | [] |
36,894,573 | 2,023 | [
{
"contexts": [
"We show that, for underdamped active particles, thermodynamic and mechanical definitions of the velocity field no longer coincide and that the density-dependent swimming speed plays the role of an effective viscosity. "
],
"name": "THERM"
}
] |
37,222,845 | 2,023 | [] |
37,059,534 | 2,023 | [] |
36,808,122 | 2,023 | [] |
37,853,986 | 2,023 | [] |
37,266,484 | 2,023 | [] |
37,879,919 | 2,023 | [] |
37,049,453 | 2,023 | [
{
"contexts": [
"The Relationship between Nutritional Risk and the Most Common Chronic Diseases in Hospitalized Geriatric Population from Central Poland.The aim of this study was to assess the relationship between Nutrition Risk Screening 2002 (NRS-2002) and the prevalence of concomitant chronic diseases among hospitalized older adults. "
],
"name": "Nutrition Risk Screening 2002 (NRS-2002)"
}
] |
37,365,581 | 2,023 | [] |
36,861,950 | 2,023 | [] |
37,641,002 | 2,023 | [] |
36,638,919 | 2,023 | [] |
37,029,367 | 2,023 | [
{
"contexts": [
"Data were analyzed with SPSS20 using descriptive and analytical statistics.\n\n\n"
],
"name": "SPSS20"
}
] |
37,337,899 | 2,023 | [] |
37,211,063 | 2,023 | [] |
37,056,362 | 2,023 | [] |
37,548,246 | 2,023 | [] |
37,195,749 | 2,023 | [] |
37,280,759 | 2,023 | [] |
37,513,181 | 2,023 | [
{
"contexts": [
"The adsorbent used in the SPE was a Cu-based metal-organic framework (Cu-MOF) prepared by the solvothermal synthesis approach. ",
"The prepared MOFs were characterized using scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR), X-ray diffractometry (XRD), differential thermogravimetric analysis (TG-DTA), and N2 adsorption-desorption experiments. "
],
"name": "THERM"
}
] |
38,019,997 | 2,023 | [] |
37,514,554 | 2,023 | [] |
36,987,294 | 2,023 | [] |
37,867,870 | 2,023 | [
{
"contexts": [
"Furthermore, we compared and analyzed the clinical characteristics of PCE and SCE, the study included 20 and 14 patients with cutaneous endometriosis diagnosed with PCE and SCE respectively. "
],
"name": "THERM"
}
] |
36,734,187 | 2,023 | [] |
37,895,912 | 2,023 | [] |
38,005,450 | 2,023 | [
{
"contexts": [
"Furthermore, certain species witnessed remarkable performance enhancements of up to 40% in single-mode identification. "
],
"name": "THERM"
}
] |
36,864,796 | 2,023 | [] |
36,833,436 | 2,023 | [] |
37,267,942 | 2,023 | [
{
"contexts": [
"This study uses X-ray photoelectron spectroscopy (XPS) to determine that there is essentially no threshold to water adsorption on the in situ cleaved MAPbBr3 (001) single crystal surface. "
],
"name": "XPS"
},
{
"contexts": [
"Using scanning tunneling microscopy (STM), it shows that the initial surface restructuring upon exposure to water vapor occurs in isolated regions, which grow in area with increasing exposure, providing insight into the initial degradation mechanism of HOIPs. "
],
"name": "STM"
},
{
"contexts": [
"The electronic structure evolution of the surface was also monitored via ultraviolet photoemission spectroscopy (UPS), evidencing an increased bandgap state density following water vapor exposure, which is attributed to surface defect formation due to lattice swelling. "
],
"name": "UPS"
}
] |
36,854,950 | 2,023 | [] |
37,010,267 | 2,023 | [] |
37,781,047 | 2,023 | [] |
37,494,944 | 2,023 | [] |
37,124,479 | 2,023 | [] |
37,489,579 | 2,023 | [] |
37,992,233 | 2,023 | [] |
37,260,906 | 2,023 | [] |
37,251,615 | 2,023 | [] |
37,556,738 | 2,023 | [
{
"contexts": [
"Latent class analysis of symptoms of depression and anxiety among older women.OBJECTIVES\n",
"Latent class analysis was used to explore the mental health subgroups of older women, and multivariate logistic regression was employed to examine the influencing factors based on the health ecological model among these subgroups.\n\n\n"
],
"name": "Latent class analysis"
},
{
"contexts": [
"Latent class analysis was used to explore the mental health subgroups of older women, and multivariate logistic regression was employed to examine the influencing factors based on the health ecological model among these subgroups.\n\n\n"
],
"name": "multivariate logistic regression"
}
] |
37,058,782 | 2,023 | [] |
36,836,108 | 2,023 | [] |
37,263,729 | 2,023 | [
{
"contexts": [
"Usefulness of thermography in the diagnosis and classification of complex regional pain syndrome.INTRODUCTION\n",
"We propose a protocol for study of complex regional pain syndrome (CRPS) based on a battery of quantitative measures (skin thermography, electrochemical skin conductance and sensory thresholds) and apply such protocol to 5 representative cases of CRPS.\n\n\n"
],
"name": "THERM"
}
] |
36,676,490 | 2,023 | [] |
37,557,054 | 2,023 | [
{
"contexts": [
"Furthermore, the implementation of a feedback strategy, in conjunction with a multi-objective algorithm, effectively shifted the distribution of the generated molecules toward optimal values of molecular weight, molecular lipophilicity, topological polar surface area, synthetic accessibility score, and quantitative estimate of drug-likeness, without the necessity of prior training sets comprising molecules endowed with pharmacological properties of interest. "
],
"name": "THERM"
},
{
"contexts": [
"FSM-DDTR: End-to-end feedback strategy for multi-objective De Novo drug design using transformers.The design of compounds that target specific biological functions with relevant selectivity is critical in the context of drug discovery, especially due to the polypharmacological nature of most existing drug molecules. ",
"In recent years, in silico-based methods combined with deep learning have shown promising results in the de novo drug design challenge, leading to potential leads for biologically interesting targets. ",
"However, several of these methods overlook the importance of certain properties, such as validity rate and target selectivity, or simplify the generative process by neglecting the multi-objective nature of the pharmacological space. ",
"In this study, we propose a multi-objective Transformer-based architecture to generate drug candidates with desired molecular properties and increased selectivity toward a specific biological target. ",
"The framework consists of a Transformer-Decoder Generator that generates novel and valid compounds in the SMILES format notation, a Transformer-Encoder Predictor that estimates the binding affinity toward the biological target, and a feedback loop combined with a multi-objective optimization strategy to rank the generated molecules and condition the generating distribution around the targeted properties. ",
"The results demonstrate that the proposed architecture can generate novel and synthesizable small compounds with desired pharmacological properties toward a biologically relevant target. ",
"The unbiased Transformer-based Generator achieved superior performance in the novelty rate (97.38%) and comparable performance in terms of internal diversity, uniqueness, and validity against state-of-the-art baselines. ",
"The optimization of the unbiased Transformer-based Generator resulted in the generation of molecules exhibiting high binding affinity toward the Adenosine A2A Receptor (AA2AR) and possessing desirable physicochemical properties, where 99.36% of the generated molecules follow Lipinski's rule of five. ",
"Furthermore, the implementation of a feedback strategy, in conjunction with a multi-objective algorithm, effectively shifted the distribution of the generated molecules toward optimal values of molecular weight, molecular lipophilicity, topological polar surface area, synthetic accessibility score, and quantitative estimate of drug-likeness, without the necessity of prior training sets comprising molecules endowed with pharmacological properties of interest. ",
"Overall, this research study validates the applicability of a Transformer-based architecture in the context of drug design, capable of exploring the vast chemical representation space to generate novel molecules with improved pharmacological properties and target selectivity. ",
"The data and source code used in this study are available at: https://github.com/larngroup/FSM-DDTR."
],
"name": "C"
},
{
"contexts": [
"FSM-DDTR: End-to-end feedback strategy for multi-objective De Novo drug design using transformers.The design of compounds that target specific biological functions with relevant selectivity is critical in the context of drug discovery, especially due to the polypharmacological nature of most existing drug molecules. ",
"The data and source code used in this study are available at: https://github.com/larngroup/FSM-DDTR."
],
"name": "FSM-DDTR"
}
] |
36,978,762 | 2,023 | [] |
37,626,124 | 2,023 | [] |
37,609,590 | 2,023 | [] |
37,683,466 | 2,023 | [] |
37,364,545 | 2,023 | [] |
37,555,663 | 2,023 | [] |
37,440,893 | 2,023 | [] |
38,050,156 | 2,023 | [] |
38,031,631 | 2,023 | [] |
37,838,066 | 2,023 | [] |
37,117,849 | 2,023 | [] |
37,280,143 | 2,023 | [] |
37,849,151 | 2,023 | [] |
37,234,734 | 2,023 | [] |
37,293,704 | 2,023 | [] |
37,158,672 | 2,023 | [] |
37,069,553 | 2,023 | [] |
37,177,682 | 2,023 | [] |
36,794,375 | 2,023 | [] |
37,369,074 | 2,023 | [] |
37,306,715 | 2,023 | [] |
36,923,257 | 2,023 | [] |
36,766,279 | 2,023 | [] |
37,497,571 | 2,023 | [
{
"contexts": [
"Meta-analysis was performed using RevMan 5.4 software. "
],
"name": "RevMan 5.4"
},
{
"contexts": [
"We searched the Cochrane Library, PubMed, Web of Science, and Embase databases for all randomized controlled trials (RCTs) and observational studies (cohort or case-control studies) that compare PCVP to PVP/KP for OVCFs. "
],
"name": "Cochrane Library"
},
{
"contexts": [
"We searched the Cochrane Library, PubMed, Web of Science, and Embase databases for all randomized controlled trials (RCTs) and observational studies (cohort or case-control studies) that compare PCVP to PVP/KP for OVCFs. "
],
"name": "PubMed"
},
{
"contexts": [
"We searched the Cochrane Library, PubMed, Web of Science, and Embase databases for all randomized controlled trials (RCTs) and observational studies (cohort or case-control studies) that compare PCVP to PVP/KP for OVCFs. "
],
"name": "Web of Science"
},
{
"contexts": [
"We searched the Cochrane Library, PubMed, Web of Science, and Embase databases for all randomized controlled trials (RCTs) and observational studies (cohort or case-control studies) that compare PCVP to PVP/KP for OVCFs. "
],
"name": "Embase databases"
}
] |
36,826,314 | 2,023 | [] |
37,647,524 | 2,023 | [] |
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