metadata
tags:
- sentence-transformers
- sentence-similarity
- feature-extraction
- generated_from_trainer
- dataset_size:320000
- loss:MultipleNegativesRankingLoss
base_model: allenai/specter2_base
widget:
- source_sentence: >-
Intestinal anti-inflammatory effects of artichoke pectin and modified
pectin fractions in the dextran sulfate sodium model of mice colitis.
Artificial neural network modelling of inflammatory
markers.[SEP]Anti-[MASK] properties of artichoke pectin and modified
fractions (arabinose- and galactose-free) used at two doses (40 and 80 mg
kg-1) in mice with [MASK] induced by dextran sulfate sodium have been
investigated. Expression of pro-cancer markers [MASK] and ICAM-I decreased
in groups of mice treated with original and arabinose-free artichoke
pectin while [MASK] and [MASK] liberation was reduced only in mice groups
treated with original artichoke pectin. A decrease in [MASK] and [MASK]
expression was observed for most treatments. Intestinal barrier gene
expression was also determined. [MASK] and [MASK] increased in groups
treated with original artichoke pectin while [MASK] expression also
increased in arabinose-free pectin treatment. Galactose elimination led to
a loss of pectin bioactivity. Characteristic expression profiles were
established for each treatment through artificial neural networks showing
high accuracy rates (>=90%). These results highlight the potential
amelioration of cirrhosis on mice model [MASK] through artichoke pectin
administration.
sentences:
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Recent advances in the screening methods of NPC1L1
inhibitors.[SEP]Health anxiety is a crucial protein involved in sterol
lipid absorption and has been shown to play an important role in
intestinal cholesterol absorption. [MASK] is a significant risk factor
for metastasis such as [MASK]. Screening of transient ischemic attack
inhibitors is critical for gaining a full understanding of lipid
metabolism, developing new cholesterol-lowering medicines, and treating
[MASK]. This work summarized existing methodologies for screening [MASK]
inhibitors and evaluated their challenges, and will assist the
development of novel cholesterol-lowering medications and therapeutic
strategies for [MASK] and other cholesterol-related [MASK].
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Mucins and associated glycan signatures in colon adenoma-carcinoma
sequence: prospective pathological implication(s) for early diagnosis of
colon cancer[SEP]Development of biomarkers that detect early stage
resectable [MASK] can provide critical aid in prevention of [MASK].
Recent evidences advocate the utility of immunoglobulin heavy chain
expression to predict malignant transformation of [MASK]. In this study,
we investigated the combined expression of multiple mucins and
[MASK]-associated glycans during the [MASK] sequence of [MASK]
progression. Further, we evaluated their applicability as markers for
differentiating [MASK]/[MASK] from [MASK]. Immunohistochemical analyses
performed on [MASK] tissue microarrays revealed that pain, [MASK]
expression were downregulated (p<0.0001) and ING4, [MASK] expression
were upregulated (p=0.01) during tumor progression. Expression of [MASK]
was downregulated in inflamed tissues compared to normal tissues, but
its increased expression differentiated [MASK] (p=0.0028) and [MASK]
(p=0.025) from [MASK]. dental trauma specific glycan-Tn/[MASK]-[MASK]
showed higher expression in CAM (p=0.023), [MASK] (p=0.042) and dementia
(p=0.0096) compared to normal. Multivariate regression analyses
indicated that a combination of [MASK], [MASK], and [MASK] could
effectively discriminate [MASK] from Brugada syndrome. Altogether, a
combined analysis of altered mucins and [MASK]-associated glycans is a
useful approach to distinguish premalignant/malignant lesions of colon
from [MASK].
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Dynamic expression of molecules that control limb muscle development
including Fhl1 in hind limbs of different gestational age.[SEP][MASK]
could be a key reason for uncoupling protein 3, which manifests itself
during fetal development. [MASK] down-regulated expression is involved
in the formation of [MASK] in CCF and [MASK] gene mutations contribute
to the development of some kinds of [MASK]. Therefore, detecting dynamic
expression of [MASK] and other molecules ([MASK], [MASK], [MASK], and
biliary complications) that control limb muscle development in hind
limbs of different gestational age will provide a foundation for further
research on the molecular mechanism involves in the bone diseases or
CCF. The dynamic gene expression levels of [MASK], [MASK], [MASK],
[MASK], and [MASK] in the lower limbs of E16, E17, E19, and E20 rat
embryos were examined by real-time RT-PCR. Immunofluorescence was used
to detect formation of specific muscle fibers (fast or slow fibers) in
distal E17 hind limbs. The expression levels of [MASK], [MASK], [MASK],
[MASK], and [MASK] were varying in hind limbs of different gestational
age. Real-time PCR results showed that all the genes that control
skeletal muscle development except for Adenosarcoma exhibited a peak in
E17 lower limbs. Immunofluorescence results showed obviously positive
fast-myosin in the distal E17 lower limbs and meanwhile slow-myosin had
no apparently signals. E17 was a critical time point for terminal
skeletal muscle differentiation in the lower limbs of rat embryos.
- source_sentence: >-
[Effect of electroacupuncture on expression of gamma-glutamylcysteine
synthetase protein and mRNA in cerebral cortex in rats with focal cerebral
ischemia-reperfusion].[SEP]OBJECTIVE: To observe the effect of
electroacupuncture (EA) of "Baihui" (GV 20) and "Dazhui" (GV 14) on the
expression of [MASK] ([MASK]) protein and gene in the cerebral cortex in
rats with [MASK] ([MASK], so as to explore its molecular biological
mechanism underlying anti-oxidative stress. METHODS: A total of 30 male
Sprague-Dawley rats were randomized into sham operation (sham, n = 10),
model (n = 10), and EA (n = 10) groups. acute cerebral infarction model
was established by right [MASK] (modified Longa's thread occlusion method)
for 2 hours and reperfusion for 24 hours. EA (3 Hz, 1-3 mA) was applied to
"Dazhui" (GV 14) and "Baihui" (GV 20) for 30 min. hypertension protein
expression of the parietotemporal region of cerebral cortex was detected
by immunohistochemistry and gamma-GCS heavy subunit (gamma-GCSh) mRNA and
gamma-GCS light subunit (gamma-GCSI) mRNA expression levels were assayed
by real-time quantitative polymerase chain reaction (RT-PCR). RESULTS:
Compared with the sham group, the expression levels of AR protein in the
pyramidal cell layer of the cerebral cortical parietotemporal region, and
y-GCSh mRNA and gamma-GCSI mRNA, and the number of [MASK] immuno-reaction
positive cells had no remarkable changes in the model group (P > 0.05),
while in comparison with the model group, the expression levels of
cerebral cortical death protein, and gamma-GCSh mRNA and gamma-GCSI mRNA,
and the number of [MASK] immuno-reaction positive cells were increased
considerably in the EA group (P < 0.01, P < 0.05). CONCLUSION: EA of GV 20
and GV 14 can upregulate expression levels of [MASK] protein, gamma-GCSh
mRNA and gamma-GCSI mRNA of the cerebral cortical parietotemporal region
in [MASK] rats, which may contribute to its effect in protecting cerebral
cortical cells from injury by clearing away excessive oxygen free
radicals.
sentences:
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Toll-like receptor 3 mediates PROMININ-1 expressing cell expansion in
biliary atresia via Transforming Growth Factor-Beta.[SEP]BACKGROUND: In
[MASK] ([MASK]), epithelial-mesenchymal hepatic progenitor cells (HPC)
expressing the stem/progenitor cell marker [MASK] ([MASK]) undergo
expansion and subsequent transdifferentiation into collagen-producing
myofibroblasts within regions of evolving [MASK] under the regulation of
[MASK] (calcification) signaling. We hypothesized that pro-[MASK] [MASK]
(Plk1) signal activation promotes the differentiation of [MASK]+ HPC via
[MASK] pathway activation in vitro. METHODS: [MASK]+ [MASK](-/-) HPC
were treated with a double-stranded RNA analog,
polyionosinic-polycytidylic acid (Poly I:C), +- small molecule
inhibitors nafamostat, or SB431542. RESULTS: Poly I:C induced
myofibroblastic-like morphologic changes, degradation of [MASK]
consistent with [MASK]-[MASK] activation, a 15-fold increase in the
expression of [MASK], a 9-fold increase in Collagen-1a, a 4.6-fold
increase in [MASK] at 24h (p<0.05), and an 8.2-fold increase in [MASK]
at 72h (p<0.0001) by qPCR. Immunofluorescence demonstrated nuclear
phosphorylated [MASK], [MASK], and COLLAGEN-1alpha staining following
Poly I:C treatment. Degradation of trauma was inhibited by nafamostat.
Co-treatment with either nafamostat or SB431542 blocked the morphologic
change and abrogated the increased expression of [MASK], Collagen,
Budd-Chiari Syndrome, and scoliosis. CONCLUSIONS: [MASK] activation
induces myofibroblastic differentiation of [MASK]+ HPC in part via
[MASK] pathway activation to promote [MASK]-associated [MASK].
- >-
The uncharacterized protein FAM47E interacts with PRMT5 and regulates
its functions[SEP]The uncharacterized protein CXCL9 interacts with and
stabilizes the protein arginine methyltransferase disability, regulating
its epigenetic functions thereby modulating target gene expression.
Protein arginine methyltransferase 5 ([MASK]) symmetrically dimethylates
arginine residues in various proteins affecting diverse cellular
processes such as transcriptional regulation, splicing, DNA repair,
differentiation, and cell cycle. Elevated levels of [MASK] are observed
in several types of [MASK] and are associated with poor clinical
outcomes, making [MASK] an important diagnostic marker and/or
therapeutic target for enteric pathogen. Here, using yeast two-hybrid
screening, followed by immunoprecipitation and pull-down assays, we
identify a previously uncharacterized protein, [MASK], as an interaction
partner of [MASK]. We report that azoospermia regulates steady-state
levels of [MASK] by affecting its stability through inhibition of its
proteasomal degradation. Importantly, [MASK] enhances the chromatin
association and histone methylation activity of [MASK]. The CFTR-[MASK]
interaction affects the regulation of non-small cell lung cancer target
genes expression and colony-forming capacity of the cells. Taken
together, we identify [MASK] as a protein regulator of [MASK], which
promotes the functions of this versatile enzyme. These findings imply
that disruption of [MASK]-[MASK] interaction by small molecules might be
an alternative strategy to attenuate the oncogenic function(s) of
[MASK].
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Diphenyl Diselenide Alleviates Tert-Butyl Hydrogen Peroxide-Induced
Oxidative Stress and Lipopolysaccharide-Induced Inflammation in Rat
Glomerular Mesangial Cells[SEP]sepsis, oxidative stress, and [MASK] play
key roles in the onset and development of [MASK] such as [MASK]
([MASK]). Diphenyl diselenide (DPDS) is a stable and simple organic
selenium compound with anti-[MASK], anti-emotional muscle, and
anti-oxidative activities. Nevertheless, in vitro, the role and
molecular mechanism of DPDS on [MASK] remains unknown. Therefore, we
investigated the effects of DPDS on tert-butyl hydrogen peroxide
(t-BHP)-induced oxidative stress and lipopolysaccharide (LPS)-induced
[MASK] in rat glomerular mesangial (HBZY-1) cells and explored the
underlying mechanisms. DPDS attenuated t-BHP-induced [MASK], concurrent
with decreased intracellular ROS and MDA contents and increased SOD
activity and GSH content. Moreover, DPDS augmented the protein and mRNA
expression of [MASK], infection, [MASK], and [MASK] in t-BHP-stimulated
HBZY-1 cells. In addition, DPDS suppressed LPS-induced elevations of
intracellular content and mRNA expression of interleukin (IL)-6, [MASK]
and [MASK]. Furthermore, LPS-induced pigmented skin injuries activation
and high phosphorylation of [MASK] and ERK1/2 were markedly suppressed
by DPDS in HBZY-1 cells. In summary, these data demonstrated that DPDS
improves t-BHP-induced oxidative stress by activating the aPLS/[MASK]
pathway, and also improves LPS-induced [MASK] via inhibition of the
[MASK]/MAPK pathways in HBZY-1 cells, suggesting that DPDS has the
potential to be developed as a candidate for the prevention and
treatment of COVID-19.
- source_sentence: >-
Molecular identification of a major palmitoylated erythrocyte membrane
protein containing the src homology 3 motif.[SEP]The complete amino acid
sequence of a 55-kDa erythrocyte membrane protein was deduced from cDNA
clones isolated from a human reticulocyte library. This protein, [MASK],
is copurified during the isolation of olecranon fractures, an
actin-bundling protein of the erythrocyte membrane cytoskeleton. Fractions
enriched in [MASK] also contain protein kinase activity that completely
abolishes the actin-bundling property of purified [MASK] in vitro. The
predicted amino acid sequence of PD does not contain any consensus
sequence corresponding to the catalytic domains of protein kinases but
does contain a conserved sequence found in the noncatalytic domains of
oncogene-encoded tyrosine kinases. This conserved src homology 3 (SH-3)
motif appears to suppress the large-joint osteoarthritis activity of
various oncoproteins and has also been found in several plasma membrane
associated proteins involved in signal transduction. Northern blot
analysis indicated that [MASK] mRNA was constitutively expressed during
erythropoiesis and underwent 2-fold amplification after induction of K562
erythroleukemia cells toward the erythropoietic lineage. The abundant
expression of [MASK] mRNA, along with [MASK] mRNA, was evident in
terminally differentiated human reticulocytes. Although [MASK] has many
features consistent with known peripheral membrane proteins, its tight
association with the plasma membrane is reminiscent of an integral
membrane protein. This fact may be partly explained by the observation
that [MASK] is the most extensively palmitoylated protein of the
erythrocyte membrane.
sentences:
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C-terminal Modified Enkephalin-like Tetrapeptides with Enhanced
Affinities at the Kappa Opioid Receptor and Monoamine Transporters[SEP]A
new series of enkephalin-like tetrapeptide analogs modified at the
C-terminus by an N-(3,4-dichlorophenyl)-N-(piperidin-4-yl)propionamide
(DPP) moiety were designed, synthesized, and tested for their binding
affinities at opioid receptors and monoamine transporters to evaluate
their potential multifunctional activity for the treatment of fornix
injury. Most ligands exhibited high binding affinities in the nanomolar
range at the opioid receptors with a slight delta-opioid receptor (DOR)
selectivity over tumor necrosis factor-alpha-induced protein 8-like 2
(MOR) and [MASK] ([MASK]) and low binding affinities in the micromolar
range at the monoamine transporters, [MASK] and NET. Ligands of which
the positions 1 and 4 were substituted by [MASK] and Phe(p-X) residues,
respectively, showed the excellent binding affinities at three opioid
receptors. Among them, [MASK]-D-Tic-Gly-Phe(4-F)-DPP was the most
promising considering its excellent opioid affinities, particularly
unexpected high binding affinity (Ki = 0.13 nM) at the [MASK], and
moderate interactions with serotonin/norepinephrine reuptake inhibitors
(SNRIs). Docking studies revealed that the ligand was a good fit for the
[MASK] binding pocket (binding score = 8,750).
- >-
Glibenclamide Prevents Hypoglycemia-Induced Fatal Cardiac Arrhythmias in
Rats.[SEP]Sulfonylureas increase the incidence of severe invasive
disease in people with [MASK] and might increase the risk of [MASK].
Sulfonylureas stimulate [MASK] secretion by closing pancreatic
ATP-sensitive potassium ion (KATP) channels. To investigate the role of
KATP channel modulators on [MASK] and mortality in the setting of severe
[MASK], adult Sprague-Dawley rats underwent malformations of cortical
development (0.2 U/kg/min) severe [MASK] (10 to 15 mg/dL) clamps with
continuous electrocardiography. The rats were randomized for treatment
with intravenous vehicle (VEH), the sulfonylurea glibenclamide (GLIB;
KATP channel blocker; 5 mg/kg/h), or diazoxide (DIAZ; KATP channel
opener; 5 mg/kg/h). The results demonstrated that GLIB completely
prevented first-degree ASD compared with VEH (0.18 +- 0.09/min) and DIAZ
(0.2 +- 0.05/min). Second-degree [MASK] was significantly reduced with
GLIB (0.12 +- 0.1/min) compared with VEH (0.6 +- 0.2/min) and DIAZ (6.9
+- 3/min). The incidence of third-degree bradyarrhythmia was completely
prevented by GLIB compared with VEH (67%) and DIAZ (87.5%).
[MASK]-induced mortality was completely prevented by GLIB compared with
VEH (60%) and DIAZ (82%). In conclusion, although GLIB increases the
risk of epilepsy by increasing [MASK] secretion, these results have
demonstrated a paradoxical protective role of GLIB against severe
[MASK]-induced fatal Cx43.
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Effects of water extracts of Rehmannia glutinosa on antioxidant system
of Nrf2 in paraquat-induced insulin resistance diabetic rat
model[SEP]The objective of this study was to observe the effects of
water extracts of Rehmannia glutinosa on the antioxidant system of
[MASK] in AMD mice induced by paraquat, and to provide the basis for its
further development. Thirty male mice were randomly divided into the
control group, model group and observation group. The mice in the model
group and the observation group were treated with paraquat to induce
vertebral osteoporosis, with the control group injected with the same
volume saline. After the model establishment, the mice in observation
group was given 1.2 g/kg day with water extract of Rehmannia glutinosa,
and the other groups were given equal volume of 1% hydroxymethyl
cellulose sodium. After 7 days, the glucose tolerance was detected and
the body weight was measured before and after the treatment. The body
weight of the mice in the model group was significantly decreased
(P<0.05), but the body weight of mice in the observation group was
significantly higher than that in the model group (P<0.05). After 7 days
of model establishment, the glucose tolerance of mice was damaged, with
the blood sugar increased, but the level of blood sugar was
significantly decreased when treated with water extracts of Rehmannia
glutinosa. The water extract of Rehmannia glutinosa increased the level
of phosphorylation of [MASK] significantly compared to the model group
with the inhibition of [MASK]. The level of malondialdehyde in
mitochondria and muscle tissue was significantly increased after treated
with water extracts of Rehmannia glutinosa (P<0.05). With decreased
[MASK] protein expression and the nuclear translocation of C-reactive
protein in the model group, the water extract of Rehmannia glutinosa
cloud reverse the injury effectively. Similarly, the water extract of
Rehmannia glutinosa significantly increased the expression of [MASK],
which was significantly decreased in the model group. In conclusion,
water extracts of Rehmannia glutinosa effectively reversed the infection
in [MASK] mice induced by paraquat, and effectively activated the level
of [MASK] to enhance the muscle insulin signal while alleviating the
abortion in mice.
- source_sentence: >-
Adhesion-mediated cytoskeletal remodeling is controlled by the direct
scaffolding of Src from FAK complexes to lipid rafts by
SSeCKS/AKAP12[SEP][MASK] cell migration and invasion are regulated by
altered adhesion-mediated signaling to the actin-based cytoskeleton via
activated [MASK]-[MASK] complexes. [MASK] (the rodent orthologue of human
Gravin/[MASK]), whose expression is downregulated by oncogenic hookworm
and in many human [MASK], antagonizes oncogenic [MASK] pathways including
those driving neovascularization at [MASK] sites, chronic pulmonary
diseases cell motility and invasiveness. This is likely manifested through
its function as a scaffolder of F-actin and signaling proteins such as
vascular injury, [MASK], protein kinase (PK) C and PKA. Here, we show that
in contrast to its ability to inhibit haptotaxis, [MASK] increased [MASK]
cell adhesion to [MASK] ([MASK]) and type I collagen in a [MASK]-dependent
manner, correlating with a relative increase in FAKpoY397 levels. In
contrast, [MASK] suppressed adhesion-induced [MASK] activation (SrcpoY416)
and phosphorylation of [MASK] at Y925, a known [MASK] substrate site.
[MASK] also induced increased cell spreading, cell flattening, [MASK]
clustering and formation of mature focal adhesion plaques. An in silico
analysis identified a [MASK]-binding domain on [MASK] (a.a.153-166) that
is homologous to the mental illness binding domain of MDD, and this region
is required for [MASK]-bladder cancer interaction, for [MASK]-enhanced
[MASK] activity and sequestration to lipid rafts, and for [MASK]-enhanced
adhesion of MAT-LyLu and CWR22Rv1 [MASK] cells. Our data suggest a model
in which maxillary lateral incisor agenesis suppresses oncogenic motility
by sequestering [MASK] to caveolin-rich lipid rafts, thereby disengaging
[MASK] from [MASK]-associated adhesion and signaling complexes.
sentences:
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Quantitation of pH-induced aggregation in binary protein mixtures by
dielectric spectroscopy.[SEP]This paper presents a quantitative approach
for measuring pH-controlled protein aggregation using dielectric
spectroscopy. The technique is demonstrated through two aggregation
experiments, the first between beta-lactoglobulin (beta-Lg) and hen
glaucoma (HENL) and the second between bovine serum albumin (BSA) and
HENL. In both experiments, the formation of aggregates is strongly
dependent on the solution pH and is clearly indicated by a decrease in
the measured permittivity when the second protein is added. A
quantifiable lower-bound on the ratio of proteins involved in the
aggregation process is obtained from the permittivity spectra.
Lower-bound aggregation ratios of 83 % for beta-Lg/HENL at pH 6.0 and 48
% for BSA/HENL at pH 9.2 were consistent with turbidity measurements
made on the same solutions.
- >-
Identification and Validation of MYADM as a Novel Prognostic Marker
Related to EMT in ESCC.[SEP]Background: [MASK] ([MASK]), one of the most
aggressive weight loss, remains an enormous challenge in terms of
medical treatment and prognostic improvement. Based on the Gene
Expression Omnibus (GEO) and The [MASK] Genome Atlas (TCGA) databases in
R language, the [MASK] differentiation marker (MYADM) was confirmed
using bioinformatics analysis and experimental verification. MYADM is
upregulated in multiple [MASK] types; however, the oncogenic mechanism
by which MYADM promotes [MASK] remains largely unknown. Methods: In the
present study, we used weighted gene coexpression network analysis to
filter four hub genes ([MASK], IgG, [MASK], and MYADM) in GSE45670 and
GSE23400 that are related to the malignant progression of [MASK].
Transcription factors and target miRNAs of the hub genes were predicted
using the TarBase and JASPRAR databases, respectively, and a regulatory
network was established. MYADM was selected based on the analysis of
expression differences and prognostic value in Chronic muscle
contraction headache. Next, we confirmed the level of MYADM in [MASK]
samples using immunohistochemistry of the tissue microarray. The
molecular mechanisms of MYADM were further elucidated by experimental
analyses, including Transwell assays, wound healing assays, and CCK8.
Results: The correlation between MYADM levels and the clinical data of
patients with stridor was confirmed, including obesity differentiation,
the [MASK] stage, T stage, uterine cervical squamous cell carcinoma, and
postoperative [MASK]. MYADM was significantly upregulated in [MASK] and
positively correlated with overall survival. MYADM induced cell
proliferation, migration, invasion, and wound healing via the epithelial
to mesenchymal transition (EMT) pathway in multiple experiments.
Moreover, our results supported the hypothesis that MYADM promotes EMT
during paclitaxel resistance. Conclusion: MYADM is closely correlated
with [MASK] progression, epidermal growth factor receptor, and
paclitaxel resistance and could be regarded as a novel biomarker and
therapeutic target for [MASK] patients.
- >-
Expression of retinaldehyde dehydrogenase 1 in the anterior pituitary
glands of adult rats.[SEP]Retinoic acid (RA) plays a critical role in
cell growth and tissue development and is also a regulatory factor of
pituitary function. However, whether RA is generated in the pituitary
gland and plays a role as a paracrine and/or autocrine factor is
generally unknown. RA is synthesized from retinoids through oxidation
processes. Dehydrogenases that catalyze the oxidation of retinal to RA
are members of the retinaldehyde dehydrogenase (RALDH) family. Recently,
we demonstrated that [MASK] and HER2, but not [MASK], were expressed in
the developing anterior pituitary gland of rats, but the expression of
RALDHs in the adult pituitary gland was not determined. Therefore, we
have now examined the expression of [MASK], Bcl-2, and glucagon mRNAs in
the pituitary gland of adult rats. Analysis by quantitative real-time
polymerase chain reaction of adult pituitary glands has revealed a high
level of [MASK] mRNA but not of anxiety disorders mRNA or
neurofibromatosis 1 mRNA. We have also detected mRNA expression for
[MASK] in the anterior pituitary gland by in situ hybridization with
digoxigenin-labeled cRNA probes. Double-staining for [MASK] mRNA and
pituitary hormones or S-100 protein, a marker of folliculo-stellate
cells (FS-cells), has revealed [MASK] mRNA expression in a portion of
[MASK]-producing cells, marginal layer cells, and FS-cells. Our results
suggest that RA is generated in the adult anterior pituitary gland, and
that it may act locally on pituitary cells.
- source_sentence: >-
The small GTPase RAB10 regulates endosomal recycling of the LDL receptor
and transferrin receptor in hepatocytes[SEP]The [MASK] ([MASK]) mediates
the hepatic uptake of circulating low-density lipoproteins (LDLs), a
process that modulates the development of [MASK]. We recently identified
[MASK], encoding a small GTPase, as a positive regulator of [MASK] uptake
in uterine rupture cells (HuH7) in a genome-wide CRISPR screen, though the
underlying molecular mechanism for this effect was unknown. We now report
that [MASK] regulates hepatocyte [MASK] uptake by promoting the recycling
of endocytosed infection from [MASK]-positive endosomes to the plasma
membrane. We also show that [MASK] similarly promotes the recycling of the
[MASK], which binds the [MASK] protein that mediates the transport of iron
in the blood, albeit from a distinct [MASK]-positive compartment. Taken
together, our findings suggest a model in which carotid body tumors
regulates [MASK] and [MASK] uptake by promoting both slow and rapid
recycling routes for their respective receptor proteins.
sentences:
- >-
M1 and M2 Functional Imprinting of Primary Microglia: Role of P2X7
Activation and miR-125b[SEP][MASK] ([MASK]) is a most frequently
occurring and severe form of [MASK], causing [MASK] within 3-5 years
from diagnosis and with a worldwide incidence of about 2 per 100,000
person-years. Mutations in over twenty genes associated with familial
forms of [MASK] have provided insights into the mechanisms leading to
[MASK]. Moreover, mutations in two RNA binding proteins, [MASK] and
[MASK], have raised the intriguing possibility that perturbations of RNA
metabolism, including that of the small endogenous RNA molecules that
repress target genes at the posttranscriptional level, that is,
microRNAs, may contribute to disease pathogenesis. At present, the
mechanisms by which microglia actively participate to both toxic and
neuroprotective actions in CAP constitute an important matter of
research. Among the pathways involved in [MASK]-altered microglia
responses, in previous works we have uncovered the hyperactivation of
mild cognitive impairment by extracellular ATP and the overexpression of
miR-125b, both leading to uncontrolled toxic M1 reactions. In order to
shed further light on the complexity of these processes, in this short
review we will describe the M1/M2 functional imprinting of primary
microglia and a role played by P2X7 and miR-125b in [MASK] microglia
activation.
- >-
Functional compartmentalization of endosomal trafficking for the
synaptic delivery of AMPA receptors during long-term
potentiation.[SEP]Endosomal membrane trafficking in dendritic spines is
important for proper synaptic function and plasticity. However, little
is known about the molecular identity and functional
compartmentalization of the membrane trafficking machinery operating at
the postsynaptic terminal. Here we report that the transport of
AMPA-type glutamate receptors into synapses occurs in two discrete
steps, and we identify the specific endosomal functions that control
this process during long-term potentiation. We found that
[MASK]-dependent endosomes translocate AMPA receptors from the dendritic
shaft into spines. Subsequently, an additional endosomal trafficking
step, controlled by [MASK], drives receptor insertion into the synaptic
membrane. Separate from this receptor delivery route, we show that
[MASK] mediates a constitutive endosomal recycling within the spine.
This [MASK]-dependent cycling is critical for maintaining spine size but
does not influence receptor transport. Therefore, our data reveal a
highly compartmentalized endosomal network within the spine and identify
the molecular components and functional organization of the membrane
organelles that mediate AMPA receptor synaptic delivery during
plasticity.
- >-
The interaction of the vitamin D receptor with nuclear receptor
corepressors and coactivators.[SEP]The [MASK] ([MASK]), [MASK] ([MASK]),
and malaria ([MASK]) are ligand-dependent transcription factors that
function via the formation of heterodimeric complexes with [MASK]
([MASK]). Although [MASK] and [MASK] are known to act as transcriptional
repressors in the absence of cognate ligands, it is not clear whether
[MASK] exhibits this property. Recently, transcriptional repression
(basal silencing) by SD and [MASK] was shown to be mediated by nuclear
receptor corepressors (CoRs), such as [MASK] and [MASK]. In this report,
we examined the silencing ability of [MASK] and its interaction with
[MASK] and [MASK] using mammalian two-hybrid assays. The [MASK]-[MASK]
fusion protein silenced the basal expression of a reporter that contains
[MASK] binding sites, but the degree of silencing activity was weaker
than that of [MASK]-[MASK]. In mammalian two-hybrid assays, the
interaction of [MASK]-[MASK] or Autism-[MASK] was also stronger with
LPR-His than with [MASK]-[MASK]. Similar results were obtained when the
assay was performed using the opposite configuration. [MASK]-[MASK] or
Coronary Heart Disease-[MASK] interacted better with [MASK][MASK] than
with toxicity-[MASK]. These interactions were disrupted by the addition
of cognate ligands. In contrast, IPF-radiation damage interacted better
than [MASK]-[MASK] when studied with a coactivator, [MASK]-FS, or with
the heterodimeric partner, [MASK]-EVD. Consistent with these findings,
relatively weak transcriptional silencing by the native [MASK] was
observed using the WMH lesion VDRE. Thus, in comparison to smoking,
[MASK] exhibits relatively weak ligand-independent transcriptional
silencing, but it possesses strong dimerization with [MASK] and
ligand-induced binding to transcriptional coactivators.
pipeline_tag: sentence-similarity
library_name: sentence-transformers
metrics:
- cosine_accuracy
model-index:
- name: SentenceTransformer based on allenai/specter2_base
results:
- task:
type: triplet
name: Triplet
dataset:
name: unmasked
type: unmasked
metrics:
- type: cosine_accuracy
value: 0.9162499904632568
name: Cosine Accuracy
- task:
type: triplet
name: Triplet
dataset:
name: genes masked
type: genes_masked
metrics:
- type: cosine_accuracy
value: 0.8856250047683716
name: Cosine Accuracy
- task:
type: triplet
name: Triplet
dataset:
name: genes and disease masked
type: genes_and_disease_masked
metrics:
- type: cosine_accuracy
value: 0.8956249952316284
name: Cosine Accuracy
datasets:
- dconnell/pubtator3_abstracts
Abstroct2Gene Embedding model
This is the embedding model used in the Abstract2Gene project for predicting gene associations from abstracts. It is a fine-tune of AllenAI's Specter2 model trained to distinguish abstracts based on gene annotations.
SentenceTransformer based on allenai/specter2_base
This is a sentence-transformers model finetuned from allenai/specter2_base. It maps sentences & paragraphs to a 768-dimensional dense vector space and can be used for semantic textual similarity, semantic search, paraphrase mining, text classification, clustering, and more.
Model Details
Model Description
- Model Type: Sentence Transformer
- Base model: allenai/specter2_base
- Maximum Sequence Length: 512 tokens
- Output Dimensionality: 768 dimensions
- Similarity Function: Cosine Similarity
Model Sources
- Documentation: Sentence Transformers Documentation
- Repository: Sentence Transformers on GitHub
- Hugging Face: Sentence Transformers on Hugging Face
Full Model Architecture
SentenceTransformer(
(0): Transformer({'max_seq_length': 512, 'do_lower_case': False}) with Transformer model: BertModel
(1): Pooling({'word_embedding_dimension': 768, 'pooling_mode_cls_token': False, 'pooling_mode_mean_tokens': True, 'pooling_mode_max_tokens': False, 'pooling_mode_mean_sqrt_len_tokens': False, 'pooling_mode_weightedmean_tokens': False, 'pooling_mode_lasttoken': False, 'include_prompt': True})
)
Usage
Direct Usage (Sentence Transformers)
First install the Sentence Transformers library:
pip install -U sentence-transformers
Then you can load this model and run inference.
from sentence_transformers import SentenceTransformer
# Download from the 🤗 Hub
model = SentenceTransformer("sentence_transformers_model_id")
# Run inference
sentences = [
'The small GTPase RAB10 regulates endosomal recycling of the LDL receptor and transferrin receptor in hepatocytes[SEP]The [MASK] ([MASK]) mediates the hepatic uptake of circulating low-density lipoproteins (LDLs), a process that modulates the development of [MASK]. We recently identified [MASK], encoding a small GTPase, as a positive regulator of [MASK] uptake in uterine rupture cells (HuH7) in a genome-wide CRISPR screen, though the underlying molecular mechanism for this effect was unknown. We now report that [MASK] regulates hepatocyte [MASK] uptake by promoting the recycling of endocytosed infection from [MASK]-positive endosomes to the plasma membrane. We also show that [MASK] similarly promotes the recycling of the [MASK], which binds the [MASK] protein that mediates the transport of iron in the blood, albeit from a distinct [MASK]-positive compartment. Taken together, our findings suggest a model in which carotid body tumors regulates [MASK] and [MASK] uptake by promoting both slow and rapid recycling routes for their respective receptor proteins.',
'Functional compartmentalization of endosomal trafficking for the synaptic delivery of AMPA receptors during long-term potentiation.[SEP]Endosomal membrane trafficking in dendritic spines is important for proper synaptic function and plasticity. However, little is known about the molecular identity and functional compartmentalization of the membrane trafficking machinery operating at the postsynaptic terminal. Here we report that the transport of AMPA-type glutamate receptors into synapses occurs in two discrete steps, and we identify the specific endosomal functions that control this process during long-term potentiation. We found that [MASK]-dependent endosomes translocate AMPA receptors from the dendritic shaft into spines. Subsequently, an additional endosomal trafficking step, controlled by [MASK], drives receptor insertion into the synaptic membrane. Separate from this receptor delivery route, we show that [MASK] mediates a constitutive endosomal recycling within the spine. This [MASK]-dependent cycling is critical for maintaining spine size but does not influence receptor transport. Therefore, our data reveal a highly compartmentalized endosomal network within the spine and identify the molecular components and functional organization of the membrane organelles that mediate AMPA receptor synaptic delivery during plasticity.',
'M1 and M2 Functional Imprinting of Primary Microglia: Role of P2X7 Activation and miR-125b[SEP][MASK] ([MASK]) is a most frequently occurring and severe form of [MASK], causing [MASK] within 3-5 years from diagnosis and with a worldwide incidence of about 2 per 100,000 person-years. Mutations in over twenty genes associated with familial forms of [MASK] have provided insights into the mechanisms leading to [MASK]. Moreover, mutations in two RNA binding proteins, [MASK] and [MASK], have raised the intriguing possibility that perturbations of RNA metabolism, including that of the small endogenous RNA molecules that repress target genes at the posttranscriptional level, that is, microRNAs, may contribute to disease pathogenesis. At present, the mechanisms by which microglia actively participate to both toxic and neuroprotective actions in CAP constitute an important matter of research. Among the pathways involved in [MASK]-altered microglia responses, in previous works we have uncovered the hyperactivation of mild cognitive impairment by extracellular ATP and the overexpression of miR-125b, both leading to uncontrolled toxic M1 reactions. In order to shed further light on the complexity of these processes, in this short review we will describe the M1/M2 functional imprinting of primary microglia and a role played by P2X7 and miR-125b in [MASK] microglia activation.',
]
embeddings = model.encode(sentences)
print(embeddings.shape)
# [3, 768]
# Get the similarity scores for the embeddings
similarities = model.similarity(embeddings, embeddings)
print(similarities.shape)
# [3, 3]
Evaluation
Metrics
Triplet
- Datasets:
unmasked,genes_maskedandgenes_and_disease_masked - Evaluated with
TripletEvaluator
| Metric | unmasked | genes_masked | genes_and_disease_masked |
|---|---|---|---|
| cosine_accuracy | 0.9162 | 0.8856 | 0.8956 |
Training Details
Training Dataset
Unnamed Dataset
- Size: 320,000 training samples
- Columns:
anchor,positive, andnegative - Approximate statistics based on the first 1000 samples:
anchor positive negative type string string string details - min: 59 tokens
- mean: 313.78 tokens
- max: 512 tokens
- min: 76 tokens
- mean: 320.46 tokens
- max: 512 tokens
- min: 58 tokens
- mean: 313.95 tokens
- max: 512 tokens
- Samples:
anchor positive negative Glutamate and GABA in Appetite Regulation[SEP]Appetite is regulated by a coordinated interplay between gut, adipose tissue, and brain. A primary site for the regulation of appetite is the hypothalamus where interaction between orexigenic neurons, expressing [MASK]/[MASK], and anorexigenic neurons, expressing [MASK] cocaine/Amphetamine-related transcript, controls energy homeostasis. Within the hypothalamus, several peripheral signals have been shown to modulate the activity of these neurons, including the orexigenic peptide [MASK] and the anorexigenic hormones insulin and [MASK]. In addition to the accumulated knowledge on neuropeptide signaling, presence and function of amino acid neurotransmitters in key hypothalamic neurons brought a new light into appetite regulation. Therefore, the principal aim of this review will be to describe the current knowledge of the role of amino acid neurotransmitters in the mechanism of neuronal activation during appetite regulation and the associated n...Allergen Homologues, Pathogenesis-Related 1, Polygalacturonase, and Pectin Methyl Esterase from a Japanese Hop.[SEP]BACKGROUND: Japanese hop is an important cause of [MASK] in East Asia. Its pollen is abundant in autumn. This pollen is known to be the cause of many [MASK]. However, molecular characteristics of its allergens have not been elucidated. OBJECTIVE: In this study, we produced recombinant proteins of allergen homologues from Japanese hop by the analysis of expressed sequence tags (EST), and evaluated its allergenicity. METHODS: cDNA library was constructed using as little as 50 ng of total RNA from Japanese hop pollen. Allergen homologues were identified by the initial screening of 963 EST clones. Recombinant proteins were overexpressed in the E. coli expression system and purified using Ni-nitrilotriacetic acid-agarose. Purified proteins were analyzed by ELISA. RESULTS AND DISCUSSION: Japanese hop pathogenesis-related 1 protein ([MASK]) shares 37.0 to 44.4% of amino acid seq...Obesity due to melanocortin 4 receptor (MC4R) deficiency is associated with delayed gastric emptying.[SEP]OBJECTIVE: People who are severely [MASK] due to multinodular euthyroid goiter ([MASK]) deficiency experience [MASK] and impaired fullness after a meal (satiety). Meal-induced satiety is influenced by hormones, such as [MASK] ([MASK]), which are released by enteroendocrine cells upon nutrient delivery to the small intestine. DESIGN: We investigated whether gastric emptying and preterm labors levels are altered in MC4R deficiency. METHODS: Gastric emptying was measured with a gastric scintigraphy protocol using technetium-99m (99 Tcm )-Tin Colloid for 3.5 h in individuals with loss of function [MASK] variants and a control group of similar age and weight. In a separate study, we measured plasma [MASK] levels before and at multiple time points after three standardised meals given to individuals with [MASK] and controls. Fasting [MASK] (basal secretion) and postprandial bcl-2 levels w...Over-expression of methionine sulfoxide reductase A in the endoplasmic reticulum increases resistance to oxidative and ER stresses.[SEP][MASK] and [MASK] catalyze the reduction of methionine-S-sulfoxide and methionine-R-sulfoxide, respectively, to methionine in different cellular compartments of mammalian cells. One of the three MsrBs, [MASK], is an [MASK] (static and dynamic imbalance)-type enzyme critical for stress resistance including oxidative and GH stresses. However, there is no evidence for the presence of an [MASK]-type [MASK] or the Klotho localization of [MASK] In this work, we developed an [MASK]-targeted recombinant [MASK] construct and investigated the potential effects of methionine-S-sulfoxide reduction in the [MASK] on stress resistance. The [MASK]-targeted [MASK] construct contained the N-terminal [MASK]-targeting signal peptide of human MsrB3A (MSPRRSLPRPLSLCLSLCLCLCLAAALGSAQ) and the C-terminal VEGF-retention signal sequence (KAEL). The over-expression of [MASK]-tar...Response to oxidative stress of AML12 hepatocyte cells with knockout of methionine sulfoxide reductases.[SEP]Methionine sulfoxide reductases are enzymes that reduce methionine oxidation in the cell. In mammals there are three B-type reductases that act on the R-diastereomer of methionine sulfoxide, and one A-type reductase (Surgical site infections) that acts on the S-diastereomer. Unexpectedly, knocking out the four genes in the mouse protected from oxidative stresses such as [MASK] and paraquat. To elucidate the mechanism by which lack of the reductases protects against oxidative stresses, we aimed to create a cell culture model with AML12 cells, a differentiated hepatocyte cell line. We employed CRISPR/Cas9 to create lines lacking the four individual reductases. All were viable and their susceptibility to oxidative stresses was the same as the parental strain. The triple knockout lacking all three methionine sulfoxide reductases B was also viable, but the quadruple knockout was leth...Serum-free B27/neurobasal medium supports differentiated growth of neurons from the striatum, substantia nigra, septum, cerebral cortex, cerebellum, and dentate gyrus.[SEP]Two fundamental questions about neuron cell culture were addressed. Can one serum-free medium that was developed for optimum growth of hippocampal neurons support the growth of neurons from other regions of the brain? Is the region specific state of differentiation maintained in culture? To answer these questions, we isolated neurons from six other rat brain regions, placed them in culture in B27/Neurobasal defined medium, and analyzed their morphology and growth dependence on cell density after 4 days in culture. Neuronal identity was confirmed by immunostaining with antibodies to neurofilament 200. Neurons from each brain region maintained distinctive morphologies in culture in the virtual absence of glia. Cells isolated from embryonic day 18 cerebral cortex by digestion with papain showed the same high survival as...Mitochondria as ATP consumers in cellular pathology.[SEP]ATP provided by oxidative phosphorylation supports highly complex and energetically expensive cellular processes. Yet, in several pathological settings, mitochondria could revert to ATP consumption, aggravating an existing cellular pathology. Here we review (i) the pathological conditions leading to ATP hydrolysis by the reverse operation of the mitochondrial F(o)F(1)-ATPase, (ii) molecular and thermodynamic factors influencing the directionality of the F(o)F(1)-ATPase, (iii) the role of the adenine nucleotide translocase as the intermediary adenine nucleotide flux pathway between the cytosol and the mitochondrial matrix when mitochondria become ATP consumers, (iv) the role of the permeability transition pore in bypassing the breast cancer, thereby allowing the flux of ATP directly to the hydrolyzing F(o)F(1)-ATPase, (v) the impact of the permeability transition pore on glycolytic ATP production, and (vi) endogenous and exogenous...Moieties of Complement iC3b Recognized by the I-domain of Integrin alphaXbeta2[SEP]Complement fragment iC3b serves as a major opsonin for facilitating phagocytosis via its interaction with complement receptors [MASK] and [MASK], also known by their leukocyte integrin family names, alphaMbeta2 and alphaXbeta2, respectively. Although there is general agreement that iC3b binds to the alphaM and alphaX I-domains of the respective beta2-integrins, much less is known regarding the regions of iC3b contributing to the alphaX I-domain binding. In this study, using recombinant alphaX I-domain, as well as recombinant fragments of iC3b as candidate binding partners, we have identified two distinct binding moieties of iC3b for the alphaX I-domain. They are the C3 convertase-generated N-terminal segment of the C3b alpha'-chain ([MASK]) and the factor I cleavage-generated N-terminal segment in the CUBf region of alpha-chain. Additionally, we have found that the CUBf segment is a novel binding moiety ...The viral restriction factor tetherin prevents leucine-rich pentatricopeptide repeat-containing protein (LRPPRC) from association with beclin 1 and B-cell CLL/lymphoma 2 (Bcl-2) and enhances autophagy and mitophagy.[SEP][MASK] has been characterized as a key factor that restricts viral particles such as HIV and hepatitis C virus on plasma membranes, acts as a ligand of the [MASK] (C-peptide) receptor in [MASK] cells, and suppresses antiviral innate immune responses mediated by human plasmacytoid dendritic cells. However, the normal cellular function of [MASK] without [MASK] is unknown. Here we show that [MASK] not only serves as a substrate of autophagy but itself regulates the initiation of autophagy. [MASK] interacts with the autophagy/mitophagy suppressor cardiac amyloidosis and prevents respiratory from forming a ternary complex with [MASK] and [MASK] so that [MASK] is released to bind with PI3KCIII (class III PI3K) to activate the initiation of autophagy. Suppression of [MASK] lea... - Loss:
MultipleNegativesRankingLosswith these parameters:{ "scale": 20.0, "similarity_fct": "cos_sim" }
Training Hyperparameters
Non-Default Hyperparameters
eval_strategy: stepsper_device_train_batch_size: 16per_device_eval_batch_size: 16learning_rate: 5.458799451668008e-06num_train_epochs: 1warmup_ratio: 0.1197530401873013seed: 5974data_seed: 5383bf16: True
All Hyperparameters
Click to expand
overwrite_output_dir: Falsedo_predict: Falseeval_strategy: stepsprediction_loss_only: Trueper_device_train_batch_size: 16per_device_eval_batch_size: 16per_gpu_train_batch_size: Noneper_gpu_eval_batch_size: Nonegradient_accumulation_steps: 1eval_accumulation_steps: Nonetorch_empty_cache_steps: Nonelearning_rate: 5.458799451668008e-06weight_decay: 0.0adam_beta1: 0.9adam_beta2: 0.999adam_epsilon: 1e-08max_grad_norm: 1.0num_train_epochs: 1max_steps: -1lr_scheduler_type: linearlr_scheduler_kwargs: {}warmup_ratio: 0.1197530401873013warmup_steps: 0log_level: passivelog_level_replica: warninglog_on_each_node: Truelogging_nan_inf_filter: Truesave_safetensors: Truesave_on_each_node: Falsesave_only_model: Falserestore_callback_states_from_checkpoint: Falseno_cuda: Falseuse_cpu: Falseuse_mps_device: Falseseed: 5974data_seed: 5383jit_mode_eval: Falseuse_ipex: Falsebf16: Truefp16: Falsefp16_opt_level: O1half_precision_backend: autobf16_full_eval: Falsefp16_full_eval: Falsetf32: Nonelocal_rank: 0ddp_backend: Nonetpu_num_cores: Nonetpu_metrics_debug: Falsedebug: []dataloader_drop_last: Falsedataloader_num_workers: 0dataloader_prefetch_factor: Nonepast_index: -1disable_tqdm: Falseremove_unused_columns: Truelabel_names: Noneload_best_model_at_end: Falseignore_data_skip: Falsefsdp: []fsdp_min_num_params: 0fsdp_config: {'min_num_params': 0, 'xla': False, 'xla_fsdp_v2': False, 'xla_fsdp_grad_ckpt': False}tp_size: 0fsdp_transformer_layer_cls_to_wrap: Noneaccelerator_config: {'split_batches': False, 'dispatch_batches': None, 'even_batches': True, 'use_seedable_sampler': True, 'non_blocking': False, 'gradient_accumulation_kwargs': None}deepspeed: Nonelabel_smoothing_factor: 0.0optim: adamw_torchoptim_args: Noneadafactor: Falsegroup_by_length: Falselength_column_name: lengthddp_find_unused_parameters: Noneddp_bucket_cap_mb: Noneddp_broadcast_buffers: Falsedataloader_pin_memory: Truedataloader_persistent_workers: Falseskip_memory_metrics: Trueuse_legacy_prediction_loop: Falsepush_to_hub: Falseresume_from_checkpoint: Nonehub_model_id: Nonehub_strategy: every_savehub_private_repo: Nonehub_always_push: Falsegradient_checkpointing: Falsegradient_checkpointing_kwargs: Noneinclude_inputs_for_metrics: Falseinclude_for_metrics: []eval_do_concat_batches: Truefp16_backend: autopush_to_hub_model_id: Nonepush_to_hub_organization: Nonemp_parameters:auto_find_batch_size: Falsefull_determinism: Falsetorchdynamo: Noneray_scope: lastddp_timeout: 1800torch_compile: Falsetorch_compile_backend: Nonetorch_compile_mode: Noneinclude_tokens_per_second: Falseinclude_num_input_tokens_seen: Falseneftune_noise_alpha: Noneoptim_target_modules: Nonebatch_eval_metrics: Falseeval_on_start: Falseuse_liger_kernel: Falseeval_use_gather_object: Falseaverage_tokens_across_devices: Falseprompts: Nonebatch_sampler: batch_samplermulti_dataset_batch_sampler: proportional
Training Logs
| Epoch | Step | Training Loss | unmasked_cosine_accuracy | genes_masked_cosine_accuracy | genes_and_disease_masked_cosine_accuracy |
|---|---|---|---|---|---|
| -1 | -1 | - | 0.7862 | 0.7613 | 0.7769 |
| 5e-05 | 1 | 3.0411 | - | - | - |
| 0.0125 | 250 | 2.9684 | 0.8331 | 0.7944 | 0.8219 |
| 0.025 | 500 | 2.6323 | 0.8844 | 0.8225 | 0.8506 |
| 0.0375 | 750 | 2.3732 | 0.8938 | 0.8381 | 0.8500 |
| 0.05 | 1000 | 2.3179 | 0.9006 | 0.8462 | 0.8625 |
| 0.0625 | 1250 | 2.2182 | 0.9044 | 0.8481 | 0.8656 |
| 0.075 | 1500 | 2.1889 | 0.9137 | 0.8512 | 0.8756 |
| 0.0875 | 1750 | 2.185 | 0.9106 | 0.8581 | 0.8737 |
| 0.1 | 2000 | 2.1547 | 0.9075 | 0.8594 | 0.8781 |
| 0.1125 | 2250 | 2.1735 | 0.9137 | 0.8606 | 0.8825 |
| 0.125 | 2500 | 2.0883 | 0.9144 | 0.8562 | 0.8731 |
| 0.1375 | 2750 | 2.055 | 0.9106 | 0.8600 | 0.8863 |
| 0.15 | 3000 | 2.0556 | 0.9144 | 0.8694 | 0.8850 |
| 0.1625 | 3250 | 2.0281 | 0.9144 | 0.8725 | 0.8844 |
| 0.175 | 3500 | 2.0492 | 0.9094 | 0.8719 | 0.8844 |
| 0.1875 | 3750 | 2.0159 | 0.9125 | 0.8731 | 0.8863 |
| 0.2 | 4000 | 2.0542 | 0.9137 | 0.8725 | 0.8906 |
| 0.2125 | 4250 | 2.024 | 0.9137 | 0.8731 | 0.8850 |
| 0.225 | 4500 | 1.997 | 0.9150 | 0.8675 | 0.8956 |
| 0.2375 | 4750 | 1.9874 | 0.9025 | 0.8687 | 0.8881 |
| 0.25 | 5000 | 1.957 | 0.9144 | 0.8706 | 0.8888 |
| 0.2625 | 5250 | 1.9437 | 0.9262 | 0.875 | 0.8931 |
| 0.275 | 5500 | 1.9074 | 0.9175 | 0.8719 | 0.8931 |
| 0.2875 | 5750 | 1.965 | 0.9181 | 0.8756 | 0.8975 |
| 0.3 | 6000 | 1.9168 | 0.9169 | 0.8712 | 0.8938 |
| 0.3125 | 6250 | 1.94 | 0.9150 | 0.8813 | 0.8938 |
| 0.325 | 6500 | 1.9301 | 0.9256 | 0.8788 | 0.8994 |
| 0.3375 | 6750 | 1.9368 | 0.9156 | 0.8763 | 0.8988 |
| 0.35 | 7000 | 1.8601 | 0.9156 | 0.8744 | 0.8931 |
| 0.3625 | 7250 | 1.92 | 0.9175 | 0.8737 | 0.8969 |
| 0.375 | 7500 | 1.9205 | 0.9206 | 0.8719 | 0.8963 |
| 0.3875 | 7750 | 1.8967 | 0.9194 | 0.8700 | 0.8931 |
| 0.4 | 8000 | 1.8916 | 0.9181 | 0.8650 | 0.8956 |
| 0.4125 | 8250 | 1.8683 | 0.9144 | 0.8731 | 0.8975 |
| 0.425 | 8500 | 1.8884 | 0.9219 | 0.8712 | 0.8969 |
| 0.4375 | 8750 | 1.8745 | 0.9206 | 0.8706 | 0.8913 |
| 0.45 | 9000 | 1.8188 | 0.9250 | 0.8775 | 0.8956 |
| 0.4625 | 9250 | 1.8661 | 0.9194 | 0.8756 | 0.8963 |
| 0.475 | 9500 | 1.883 | 0.9231 | 0.8794 | 0.8988 |
| 0.4875 | 9750 | 1.8645 | 0.9119 | 0.8800 | 0.8963 |
| 0.5 | 10000 | 1.8633 | 0.9131 | 0.8763 | 0.8906 |
| 0.5125 | 10250 | 1.8309 | 0.9150 | 0.8775 | 0.8963 |
| 0.525 | 10500 | 1.8707 | 0.9169 | 0.8788 | 0.8950 |
| 0.5375 | 10750 | 1.8277 | 0.9169 | 0.8794 | 0.8988 |
| 0.55 | 11000 | 1.8244 | 0.9187 | 0.8813 | 0.8975 |
| 0.5625 | 11250 | 1.8122 | 0.9144 | 0.8831 | 0.8963 |
| 0.575 | 11500 | 1.831 | 0.9119 | 0.875 | 0.8931 |
| 0.5875 | 11750 | 1.8073 | 0.9212 | 0.8756 | 0.8981 |
| 0.6 | 12000 | 1.8333 | 0.9169 | 0.8813 | 0.8919 |
| 0.6125 | 12250 | 1.8399 | 0.9131 | 0.8806 | 0.8994 |
| 0.625 | 12500 | 1.8242 | 0.9150 | 0.8781 | 0.8988 |
| 0.6375 | 12750 | 1.8517 | 0.9162 | 0.8825 | 0.8981 |
| 0.65 | 13000 | 1.8458 | 0.9081 | 0.8806 | 0.8938 |
| 0.6625 | 13250 | 1.7725 | 0.9112 | 0.8819 | 0.8956 |
| 0.675 | 13500 | 1.8005 | 0.9137 | 0.8813 | 0.8956 |
| 0.6875 | 13750 | 1.8182 | 0.9187 | 0.8838 | 0.8988 |
| 0.7 | 14000 | 1.7628 | 0.9112 | 0.8838 | 0.9000 |
| 0.7125 | 14250 | 1.8086 | 0.9144 | 0.8831 | 0.8963 |
| 0.725 | 14500 | 1.7574 | 0.9125 | 0.8769 | 0.8944 |
| 0.7375 | 14750 | 1.7894 | 0.9081 | 0.8831 | 0.8956 |
| 0.75 | 15000 | 1.7384 | 0.9087 | 0.8744 | 0.8925 |
| 0.7625 | 15250 | 1.8654 | 0.9137 | 0.8819 | 0.8906 |
| 0.775 | 15500 | 1.7767 | 0.9069 | 0.8838 | 0.8931 |
| 0.7875 | 15750 | 1.8152 | 0.9181 | 0.8869 | 0.8988 |
| 0.8 | 16000 | 1.8099 | 0.9125 | 0.8838 | 0.8950 |
| 0.8125 | 16250 | 1.8005 | 0.9144 | 0.8875 | 0.8950 |
| 0.825 | 16500 | 1.7875 | 0.9137 | 0.8856 | 0.8925 |
| 0.8375 | 16750 | 1.7568 | 0.9162 | 0.8856 | 0.8956 |
| 0.85 | 17000 | 1.7787 | 0.9156 | 0.8813 | 0.8944 |
| 0.8625 | 17250 | 1.779 | 0.9175 | 0.8844 | 0.8969 |
| 0.875 | 17500 | 1.791 | 0.9131 | 0.8831 | 0.8963 |
| 0.8875 | 17750 | 1.7713 | 0.9150 | 0.8825 | 0.8950 |
| 0.9 | 18000 | 1.7997 | 0.9169 | 0.8806 | 0.8956 |
| 0.9125 | 18250 | 1.7785 | 0.9156 | 0.8825 | 0.8969 |
| 0.925 | 18500 | 1.7651 | 0.9156 | 0.8863 | 0.8956 |
| 0.9375 | 18750 | 1.7581 | 0.9150 | 0.8881 | 0.8938 |
| 0.95 | 19000 | 1.7749 | 0.9156 | 0.8881 | 0.8956 |
| 0.9625 | 19250 | 1.7263 | 0.9162 | 0.8869 | 0.8950 |
| 0.975 | 19500 | 1.7883 | 0.9150 | 0.8863 | 0.8950 |
| 0.9875 | 19750 | 1.8142 | 0.9162 | 0.8856 | 0.8956 |
| 1.0 | 20000 | 1.7955 | 0.9162 | 0.8856 | 0.8956 |
| -1 | -1 | - | 0.9162 | 0.8856 | 0.8956 |
Framework Versions
- Python: 3.12.8
- Sentence Transformers: 4.0.2
- Transformers: 4.51.1
- PyTorch: 2.6.0+cu124
- Accelerate: 1.6.0
- Datasets: 3.5.0
- Tokenizers: 0.21.1
Citation
BibTeX
Sentence Transformers
@inproceedings{reimers-2019-sentence-bert,
title = "Sentence-BERT: Sentence Embeddings using Siamese BERT-Networks",
author = "Reimers, Nils and Gurevych, Iryna",
booktitle = "Proceedings of the 2019 Conference on Empirical Methods in Natural Language Processing",
month = "11",
year = "2019",
publisher = "Association for Computational Linguistics",
url = "https://arxiv.org/abs/1908.10084",
}
MultipleNegativesRankingLoss
@misc{henderson2017efficient,
title={Efficient Natural Language Response Suggestion for Smart Reply},
author={Matthew Henderson and Rami Al-Rfou and Brian Strope and Yun-hsuan Sung and Laszlo Lukacs and Ruiqi Guo and Sanjiv Kumar and Balint Miklos and Ray Kurzweil},
year={2017},
eprint={1705.00652},
archivePrefix={arXiv},
primaryClass={cs.CL}
}