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<!DOCTYPE plist PUBLIC "-//Apple//DTD PLIST 1.0//EN" "http://www.apple.com/DTDs/PropertyList-1.0.dtd">
<plist version="1.0">
<dict>
<key>BuildMachineOSBuild</key>
<string>15C50</string>
<key>CFBundleDevelopmentRegion</key>
<string>English</string>
<key>CFBundleExecutable</key>
<string>ACPIBatteryManager</string>
<key>CFBundleGetInfoString</key>
<string>1.60.5, Copyright 2011 Apple Inc., RehabMan 2012</string>
<key>CFBundleIdentifier</key>
<string>org.rehabman.driver.AppleSmartBatteryManager</string>
<key>CFBundleInfoDictionaryVersion</key>
<string>6.0</string>
<key>CFBundleName</key>
<string>ACPIBatteryManager</string>
<key>CFBundlePackageType</key>
<string>KEXT</string>
<key>CFBundleShortVersionString</key>
<string>1.60.5</string>
<key>CFBundleSignature</key>
<string>????</string>
<key>CFBundleSupportedPlatforms</key>
<array>
<string>MacOSX</string>
</array>
<key>CFBundleVersion</key>
<string>1.60.5</string>
<key>DTCompiler</key>
<string>com.apple.compilers.llvm.clang.1_0</string>
<key>DTPlatformBuild</key>
<string>7C68</string>
<key>DTPlatformVersion</key>
<string>GM</string>
<key>DTSDKBuild</key>
<string>12D75</string>
<key>DTSDKName</key>
<string>macosx10.8</string>
<key>DTXcode</key>
<string>0720</string>
<key>DTXcodeBuild</key>
<string>7C68</string>
<key>IOKitPersonalities</key>
<dict>
<key>ACPI AC Adapter</key>
<dict>
<key>CFBundleIdentifier</key>
<string>org.rehabman.driver.AppleSmartBatteryManager</string>
<key>IOClass</key>
<string>rehab_ACPIACAdapter</string>
<key>IONameMatch</key>
<string>ACPI0003</string>
<key>IOProbeScore</key>
<integer>1000</integer>
<key>IOProviderClass</key>
<string>IOACPIPlatformDevice</string>
</dict>
<key>ACPI Battery Manager</key>
<dict>
<key>CFBundleIdentifier</key>
<string>org.rehabman.driver.AppleSmartBatteryManager</string>
<key>Configuration</key>
<dict>
<key>Correct16bitSignedCurrentRate</key>
<true/>
<key>CorrectCorruptCapacities</key>
<true/>
<key>CurrentDischargeRateMax</key>
<integer>20000</integer>
<key>EstimateCycleCountDivisor</key>
<integer>6</integer>
<key>StartupDelay</key>
<integer>50</integer>
<key>UseDesignVoltageForCurrentCapacity</key>
<true/>
<key>UseDesignVoltageForDesignCapacity</key>
<true/>
<key>UseDesignVoltageForMaxCapacity</key>
<true/>
<key>UseExtendedBatteryInformationMethod</key>
<true/>
<key>UseExtraBatteryInformationMethod</key>
<true/>
</dict>
<key>IOClass</key>
<string>rehab_ACPIBatteryManager</string>
<key>IONameMatch</key>
<string>PNP0C0A</string>
<key>IOProbeScore</key>
<integer>1000</integer>
<key>IOProviderClass</key>
<string>IOACPIPlatformDevice</string>
</dict>
<key>ACPI Battery Tracker</key>
<dict>
<key>CFBundleIdentifier</key>
<string>org.rehabman.driver.AppleSmartBatteryManager</string>
<key>IOClass</key>
<string>rehab_BatteryTracker</string>
<key>IOMatchCategory</key>
<string>rehab_BatteryTracker</string>
<key>IOProviderClass</key>
<string>IOResources</string>
<key>IOResourceMatch</key>
<string>IOKit</string>
</dict>
</dict>
<key>NSHumanReadableCopyright</key>
<string>Copyright © 2011 Apple Inc. All rights reserved, RehabMan 2012</string>
<key>OSBundleLibraries</key>
<dict>
<key>com.apple.iokit.IOACPIFamily</key>
<string>1.0d1</string>
<key>com.apple.kpi.iokit</key>
<string>9.0</string>
<key>com.apple.kpi.libkern</key>
<string>9.0</string>
</dict>
<key>OSBundleRequired</key>
<string>Root</string>
<key>Source Code</key>
<string>https://github.com/RehabMan/OS-X-ACPI-Battery-Driver</string>
</dict>
</plist>
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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Training in the Use of Bruker and Varian Spectrometers and NMR - Rani Venkitakrishnan. | {
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[Progress in labeled immunoassay based on SERS].
Labeled immunoassay utilizing surface-enhanced Raman spectroscopy (SERS) is a new-style research technology. The discovery and confirmation of surface-enhanced Raman spectroscopy have made Raman spectroscopy a powerful tool in many research fields. SERS has the advantages such as high sensibility and selectivity, also it is suitable for the study of liquid substance. In recent years, it has shown potential application future in biomedical field, and also developed fast in labeled immunoassay. The principle, specialty, problem and recent advances of labeled immunoassay based on SERS were reviewed in terms of detection limits, non-specific adsorption and multi-analyte immunoassay. The latest advancement in the improvement of detection limits was summarized, along with the introduction of some work in our lab, as well as expatiating on the effect of non-specific adsorption. Finally, the development trends and application perspectives were discussed. | {
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Congratulations, Starlight! You've truly earned it.And your graduation, while a surprise, was much more exciting than that of your new friend Dr. Pie. | {
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The present invention relates to a light source-optical fiber coupler for coupling light emitted from a light source onto an end surface of an optical fiber by a gradient index rod lens and particularly to a light source-optical fiber coupler in which a light source and a gradient index rod lens having a planar end surface facing the light source and a spherical end surface facing an optical fiber are arranged closely to each other to thereby make it possible to reduce the size of the coupler.
In an optical communication system or the like, a lens is used so that a diffused luminous flux emitted from a light source such as a semiconductor laser or the like is transmitted to an optical fiber core by the lens. Heretofore, a spherical lens, an aspherical lens, a gradient index rod lens, or the like, has been used as the lens to perform optical coupling.
The spherical lens can be produced most inexpensively but is insufficient from the point of view of a characteristic to optically couple a semiconductor laser to a single-mode optical fiber with low loss. This is because the core diameter of the single-mode optical fiber is so small that strict performance is required of the aberration of the lens in order to improve optical coupling efficiency Therefore, an aspherical lens is generally used as a highly coupled lens.
On the other hand, when a gradient index rod lens is used, the rod lens is used in the condition a semiconductor laser side end surface of the rod lens is provided as a convex spherical surface and an optical fiber side end surface of the rod lens is provided as a planar surface because a high numerical aperture (NA) is required for coupling of light emitted from the semiconductor laser (see JP-A-61-107207). This is based on the idea that light-condensing power is obtained by the convex spherical surface while the aberration generated in the convex spherical surface is cancelled by the refractive-index distribution shape of the rod lens.
In order to produce an aspherical lens, however, a mold was required in accordance with the kind of the aspherical lens. A heat-resistant material and superfine machining were required for the production. Hence, there was a problem that the cost of the lens increased particularly in the case of multikind and small quantity production.
On the other hand, in the case of a gradient index rod lens having a convex spherical surface on a semiconductor laser side, it was difficult to produce a high numerical aperture lens because the controllable range of the refractive-index distribution was narrow. Moreover, the lens length of the rod lens became long, so that the material cost for the lens increased.
An object of the present invention is to provide a light source-optical fiber coupler which can couple a semiconductor laser to a single-mode optical fiber with low loss and which can be produced as a small-size coupler inexpensively and easily.
A subject of the present invention is a light source-optical fiber coupler using a gradient index rod lens for coupling a diffused luminous flux emitted from a light source onto an end surface of an optical fiber. Here, the gradient index rod lens has a planar end surface on the light source side, and a convex spherical end surface on the optical fiber side. The gradient index rod lens has a light source side numerical aperture NA2 in a range of from 0.40 to 0.75, an effective lens radius r0 in a range of from 0.3 to 1.0 mm, and a spherical curvature radius R1 in a range of from 1.2 to 2.0 mm.
In the present invention, a semiconductor laser is generally used as the light source. When a single-mode optical fiber having a small diameter is used as the optical fiber which is a partner of optical coupling, the highly efficient optical coupling effect is particularly remarkable. In the present invention, the planar surface is used on the semiconductor laser side and the convex spherical surface is used on the optical fiber, so that high numerical aperture is attained and the aberration of light can be corrected by the refractive-index distribution shape of the rod lens. Hence, reduction in size of an optical module can be achieved when such a gradient index rod lens having a small lens diameter is used.
Preferably, the gradient index rod lens used in the present invention has a center axis refractive index n0 in a range of from 1.5 to 1.8, a value of n0xc2x7gxc2x7r0 in a range of from 0.40 to 0.65 (in which a is a secondary refractive-index distribution coefficient), and a value of Z/R1 in a range of from 1.1 to 2.5 (in which Z is the lens length of the rod lens) . Preferably, the gradient index rod lens has a value of g in a range of from 0.38 to 0.50, a value of h4 in a range of from xe2x88x920.2 to 1.8, a value of h6 in a range of from xe2x88x920.5 to 10, and a value of h8 in a range of from xe2x88x9225 to 45 (in which h4, h6 and h8 are higher-order refractive-index distribution coefficients respectively).
A practical optical module structure may be preferably configured as follows. A semiconductor laser is used as the light source. A chip of the semiconductor laser and the gradient index rod lens are retained in a housing in the condition that they are arranged closely to each other. The housing is provided so that a ferrule of an optical plug which is used as a mating partner and in which a single-mode optical fiber is retained can be fitted and retained in the housing.
The present disclosure relates to the subject matter contained in Japanese patent application No. 2000-326471 (filed on Oct. 26, 2000), which is expressly incorporated herein by reference in its entirety. | {
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Q:
Why does timezone info from Ruby sequel and Postgres psql differ?
Here is a query result from Postgres:
$ psql ... -c 'select the_date from foo where foo_id in (998,999)'
the_date
------------------------
2012-03-07 09:34:47.98
2012-03-16 11:31:25.336
the_date is "timestamp without time zone".
Here is a Ruby program:
#!/usr/bin/env ruby
require 'sequel'
@DB = Sequel.connect({...})
query = "select the_date from foo where foo_id in (998,999)"
@DB[query].each do |row|
warn row
end
and some output:
{:the_date=>2012-03-07 09:34:47 -0600}
{:the_date=>2012-03-16 11:31:25 -0500}
Where does the -0500 and -0600 come from? That is the "Olson timezone" of the server and the client machines (US/Central), but why does Ruby add it and psql does not?
I've been reading the docs, and I'm thoroughly confused.
The server is Postgres 9.0.4, the client is psql 9.1.4, sequel is 3.33.0.
A:
The column is of type 'timestamp without timezone'. Thus when Postgres displays a value in this column it just displays the timestamp with no timezone. However, Sequel wants to convert a Postgres timestamp to an instance of the Ruby Time class, and an instance of the Time class must have a timezone specified - either it's a time in the local timezone or it's a time in UTC. Thus Sequel must choose one. By default, it's choosing your local timezone.
You may configure the database and application timezone in Sequel. See http://sequel.rubyforge.org/rdoc/classes/Sequel/Timezones.html
For example, here's the default Sequel behavior with a database I had handy:
> c['select * from actors'].each do |row|; puts row[:created_at]; end
Thu Jul 12 20:33:17 -0400 2012
Here the timestamp is assumed to be in my local timezone (EDT).
However, if I do this:
> Sequel.database_timezone = :utc
=> :utc
> c['select * from actors'].each do |row|; puts row[:created_at]; end
Thu Jul 12 20:33:17 UTC 2012
Then the timestamp is assumed to be in UTC.
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Q:
AS3 9 slice scaling
i'm making window component on Flash Professional CS4 and now i have 1 problem. At the top of window is dynamic textfield for title. When i scale window text is also scaling. So is there any way to make textfield fixed in same position and same size?
P.S. 9-slice scaling is enabled.
A:
You should separate your window's background from the rest of it:
window > title
> background
Your background would be the only clip to be 9-sliced and you will scale your window by doing:
window.getChildByName("background").scaleX = newScaleX;
window.getChildByName("background").scaleY = newScaleY;
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second derivative of -5363321*i**2 - 751678*i.
-10726642
What is the third derivative of 13603*i**3*j**2 - 2*i**3 + 6438*i**2*j - 167*i**2 + i*j**2 wrt i?
81618*j**2 - 12
What is the second derivative of -907*b**5 - b**3 - 66513*b**2 - 368735490*b?
-18140*b**3 - 6*b - 133026
What is the second derivative of 23483466*n**3 - 51370098*n wrt n?
140900796*n
What is the first derivative of -19458115*n + 35688118 wrt n?
-19458115
What is the second derivative of -65440406*v**5 - 2*v - 14726294?
-1308808120*v**3
What is the derivative of -11059824*h - 9600016?
-11059824
What is the second derivative of 2*d**3*h*z + 4749*d**3 + 2479*d**2*h**2 - 5721*d*h**2*z + 2*d*h**2 - 35*d*h*z + 2*d*h + 2*d*z wrt d?
12*d*h*z + 28494*d + 4958*h**2
What is the second derivative of -13*k**4 - 2266*k**3 - 399*k**2 - 183*k + 9580 wrt k?
-156*k**2 - 13596*k - 798
What is the third derivative of 1913*d**3*f**3 - 93*d**3*f**2 - 37*d**3*f + 2*d**2*f**2 - 5*d**2*f + 517*f**4 + f wrt f?
11478*d**3 + 12408*f
What is the second derivative of -f**5 - 8932800*f**3 + 4845947*f?
-20*f**3 - 53596800*f
Find the first derivative of -20405*b**4 + b**2 - 7*b - 5803067 wrt b.
-81620*b**3 + 2*b - 7
Find the third derivative of -19*b**4*c - 202833*b**3*c + 222*b**2*c - 3*b**2 - 14*c - 1 wrt b.
-456*b*c - 1216998*c
Differentiate -516*h**3 + 2513*h**2 + 34256237.
-1548*h**2 + 5026*h
Differentiate 612*x**4 + 299*x - 1712925 wrt x.
2448*x**3 + 299
What is the second derivative of -12126166*v**4 + 4851272*v - 1 wrt v?
-145513992*v**2
What is the first derivative of 334954118*d**4 - 650794861 wrt d?
1339816472*d**3
What is the second derivative of -2*z**3 - 802408*z**2 + 5440950*z?
-12*z - 1604816
Find the third derivative of -13*o**4 - 59972*o**3 + o**2 - 11*o - 28150 wrt o.
-312*o - 359832
What is the third derivative of -1176300*r**5 - 41*r**3 + 365*r**2 + 916*r + 22 wrt r?
-70578000*r**2 - 246
Find the first derivative of -2308*l*w**3 - 3458*l + 2*w**3 - 72879544*w wrt l.
-2308*w**3 - 3458
Find the third derivative of k**5 - k**4 + 1872860*k**3 - 83217*k**2 + k + 352.
60*k**2 - 24*k + 11237160
Find the third derivative of -7438835*b**4 - 16*b**2 + b + 61539.
-178532040*b
Find the first derivative of 1873*y**4 - 161*y**3 + 2*y**2 - 11379107.
7492*y**3 - 483*y**2 + 4*y
What is the first derivative of -285*c**3*r - 222247078*c**3 + 370534*c*r wrt r?
-285*c**3 + 370534*c
What is the second derivative of -760440033*g**2*j - 2*g*j + g - 7*j - 5018597 wrt g?
-1520880066*j
What is the first derivative of -g*r*x + g*r - 2*g*x - 32*g - 113*r*x - 2076*r + 2270*x - 2 wrt x?
-g*r - 2*g - 113*r + 2270
Find the second derivative of -107697*b*q**3 + 2*b*q**2 + 2*b*q - 308*b + 7*q**3 - 4*q**2 - 23764*q - 1 wrt q.
-646182*b*q + 4*b + 42*q - 8
Find the third derivative of 4*a*i*o**3 + a*i*o**2 - 2*a*i*o - 299*a*i - 585*a*o**3 - 991*a*o**2 + 2*i*o**3 + 2042*o**3 - o - 2 wrt o.
24*a*i - 3510*a + 12*i + 12252
Find the first derivative of -10495006*a**3*h + 48*a**3 + 25*a**2 - 29*a wrt h.
-10495006*a**3
Differentiate -3966*v**4 + 232*v**3 + 2885416 with respect to v.
-15864*v**3 + 696*v**2
Find the second derivative of -915942710*r**4 + 64457162*r.
-10991312520*r**2
What is the derivative of 6*r*t + 2625916*r + 3980*t**4 - 20*t**3 - 1 wrt t?
6*r + 15920*t**3 - 60*t**2
What is the derivative of -1354280*u**2 - 34*u - 289184622 wrt u?
-2708560*u - 34
What is the third derivative of -20*f**5 - 66383*f**3 + 12409720*f**2?
-1200*f**2 - 398298
Differentiate 130151431*g*l**2 - l**2 + 11014810 wrt g.
130151431*l**2
What is the second derivative of -a**3*f - 1485*a**3 - 33*a**2*f + 97*a**2 + 404*a*f - a + 242*f + 84 wrt a?
-6*a*f - 8910*a - 66*f + 194
What is the second derivative of 408356257*o**2*w**2 - 5*o**2 + 25906872*w wrt w?
816712514*o**2
Find the third derivative of 54416176*s**3 + 1424*s**2 + 1281*s - 5 wrt s.
326497056
Find the first derivative of -73340749*k + 206637680 wrt k.
-73340749
What is the derivative of 3*c**2*q**2 - 1904*c**2 - 249*c*q - 40210558*q**2 wrt c?
6*c*q**2 - 3808*c - 249*q
What is the second derivative of -176*b**4 - 1650650*b**2 - 221127488*b wrt b?
-2112*b**2 - 3301300
Differentiate -134821636*a*p**3 + 2*p**3 - 17821995*p**2 - p wrt a.
-134821636*p**3
Find the third derivative of -2732577*b**4*d**3 - 239*b**2*d + 6634*b*d**3 wrt b.
-65581848*b*d**3
Differentiate -2308357*l**3 + 15*l**2 - l + 254569136.
-6925071*l**2 + 30*l - 1
Find the third derivative of -18715*m**2*v**4 - m**2*v**2 - 1344*m**2 + 590*m*v**4 - 29423*v**2 wrt v.
-449160*m**2*v + 14160*m*v
Differentiate 144510*a**4 + 98*a**3 + 68283580 with respect to a.
578040*a**3 + 294*a**2
Find the first derivative of 12293606*y - 4576216.
12293606
Find the second derivative of o**4 + 15128295*o**3 + 2*o - 3372779.
12*o**2 + 90769770*o
Find the second derivative of 75961*w**4 + 10*w**3 + 42*w**2 - 41495653*w - 1 wrt w.
911532*w**2 + 60*w + 84
What is the derivative of -147128178*i**2 - 2*i - 3763263?
-294256356*i - 2
What is the second derivative of -30671*a**3*h**2 + 2*a**3*h + a**3 + 310*a**2*h + a*h**4 + 2*a*h**2 - 2*a - 41*h + 2 wrt h?
-61342*a**3 + 12*a*h**2 + 4*a
What is the third derivative of 34*g**3*j*q - 2*g**3*j - 46*g**3*q + 85*g**3*z - 2*g**2*q*z - 12*g**2 - 3*g*j*z + 251*q*z wrt g?
204*j*q - 12*j - 276*q + 510*z
What is the second derivative of 2*g**2*i*l**2 + 303*g**2*i - 3*g**2*l - 2*g**2 + 3154*g*i*l**2 - 1518*g*l**2 + 38*g*l - 27*l wrt l?
4*g**2*i + 6308*g*i - 3036*g
What is the second derivative of -191213*b**2*l - 245*b**2*y - 431*b*l*y - 2*b*y + 14*b + 4*l*y - 5*l + 2*y wrt b?
-382426*l - 490*y
What is the first derivative of 199537485*k**3 + 56836601 wrt k?
598612455*k**2
Find the third derivative of o**4*w + 3*o**4 + 79*o**3*w + 482*o**3 + 8*o**2 + 80158*w - 1 wrt o.
24*o*w + 72*o + 474*w + 2892
What is the second derivative of -60468016*u**5 - 51917*u + 506 wrt u?
-1209360320*u**3
What is the second derivative of 22233*k*s**2*u**3 + 114*k*s*u**3 - k*s*u + 10*s**2*u**3 - 4*s**2*u - 119*s*u + 40*u wrt s?
44466*k*u**3 + 20*u**3 - 8*u
What is the first derivative of -48157963*q**3 - 21415248?
-144473889*q**2
Find the third derivative of -2004161*q**4 + 25145071*q**2.
-48099864*q
Find the second derivative of 60803733*f**2 + 28499239*f.
121607466
Differentiate 1285317*f**2 - f*o + 11024250*o with respect to f.
2570634*f - o
What is the derivative of -9285692*b**2 + 12990848?
-18571384*b
What is the third derivative of -39065816*t**3 + 36037591*t**2?
-234394896
Differentiate -71462*n**3 - 66*n**2 - n - 154279025 with respect to n.
-214386*n**2 - 132*n - 1
Find the third derivative of -37*f*k**3 - 4*f*k*v + 27*f + 9250*k**3*v**2 + 2*k**3 - 2791*k**2*v**2 - k**2*v wrt k.
-222*f + 55500*v**2 + 12
Differentiate -236221*b*i*v**2 + b*v**3 - b*v + 2*b - 20*i*v**3 + 3*i - 747*v**3 - 2*v - 135 with respect to i.
-236221*b*v**2 - 20*v**3 + 3
Find the third derivative of 186135357*f**3 - 81851438*f**2.
1116812142
What is the third derivative of -481966*m**2*o**3 - 17923*m**2*o**2 - 22*o**4 - 11*o**2 wrt o?
-2891796*m**2 - 528*o
Differentiate 2299*b*f*x + 76*b - 4312*f*x**2 - 78515*x**2 wrt f.
2299*b*x - 4312*x**2
What is the third derivative of 94824*n*p**4 - n*p**2 + 31*n*p - 3*n + 30*p**6 - 258*p**2 + 2 wrt p?
2275776*n*p + 3600*p**3
Differentiate 519182500*q - 257264126.
519182500
Differentiate -4*b*f*k - 7*b*f + 173068*b - 62659750*f*k with respect to b.
-4*f*k - 7*f + 173068
What is the first derivative of -63569974*z**3 + 2*z**2 - 294252969?
-190709922*z**2 + 4*z
What is the second derivative of 560251832*c**2 + 675356680*c?
1120503664
What is the third derivative of 164*i*j**3 + 2483*i*j**2 - 1023*i + 40323*j**3 - 2*j**2 wrt j?
984*i + 241938
What is the derivative of -9*p**3 - 84488*p - 5319634 wrt p?
-27*p**2 - 84488
What is the third derivative of -213002649*p**3 - 9*p**2 + 212010*p - 1?
-1278015894
What is the second derivative of 124*a**2*p**3 + 1453*a**2*p**2 + 122*a**2 - a*p**3 + a*p**2 + 2*a*p + 370*p**3 + 8*p - 1381 wrt a?
248*p**3 + 2906*p**2 + 244
What is the third derivative of 20168499*o**3 - 412*o**2 - 6695 wrt o?
121010994
Find the first derivative of 837*o**4 + 2*o**3 + 13*o**2 + 50291 wrt o.
3348*o**3 + 6*o**2 + 26*o
What is the third derivative of -53*v**5 - 1420574*v**4 - 1159*v**2 + 17162?
-3180*v** | {
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Alzheimer's disease damages the nervous system in many different ways. This is because the disease affects not only neurons but also other brain cells, such as the astrocytes. These support the normal function of neurons and are involved in the regulation of cerebral blood flow. Through experimental studies scientists of the German Center for Neurodegenerative Diseases (DZNE) at the Bonn and Berlin sites have now gained new insights into how Alzheimer's interferes with the metabolism of astrocytes. The research team also showed that the pathological changes of the astrocytes can be mitigated by pharmacological treatment. The triggering molecules turned out to be energy carriers of the cell such as ATP: These molecules can induce the astrocytes to switch into a hyperactive state, which is characterized by sudden fluctuations in the concentration of calcium. As the researchers describe in the scientific journal "Nature Communications", their study suggests a novel potential approach for the treatment of Alzheimer's disease.
Share on Pinterest Besides neurons, the brain harbors a variety of other cells with very specific functions. This image (tissue sample of a mouse with hallmarks of Alzheimer's disease) shows some of them. The projections of so-called astrocytes are colored white. Astrocytes support the function of neurons and are involved in the regulation of cerebral blood flow. In Alzheimer's disease they alter their shapes and activity. This image also depicts the nuclei (blue) of astrocytes, neurons and other cells. The green structures stem from a protein associated with Alzheimer's.
Credit: DZNE / A. Delekate, T. Schumacher, G. Petzold
In a way, the brain resembles a large symphonic orchestra, whereby although the various instruments play together, each assumes a special part. Accordingly, the brain consists of nerve cells, also called "neurons", that are woven into a network in which they relay signals to one another. On the other hand, so-called glial cells are also equally important for brain function. These cells were once regarded as mere connective tissue of the brain. However, it is now known that they assume tasks that are far more complex than previously thought. One prominent member of this versatile family of glial cells are the astrocytes.
"Astrocytes have various functions in the brain. For example, they supply the neurons with nutrients, but they also dispose waste products of metabolism", explains Professor Gabor Petzold, who leads a research group at the Bonn site of the DZNE and also supervises the Neurovascular Unit at the University Hospital Bonn. „In addition, they influence the communication of neurons with one another, and are involved in the control of cerebral blood flow."
Alzheimer's disease alters the astrocytes
It has long been known that astrocytes change their shapes as a consequence of Alzheimer's. Cells located near the "plaques", as the protein deposits typical for this disease are called, grow in size and form additional extensions. However, until know it was largely unclear how these changes affect the function of astrocytes.
Thus, Petzold and his colleagues studied mice whose brains exhibited the typical protein deposits of Alzheimer's. They discovered that the calcium metabolism of astrocytes in the vicinity of plaques was disturbed. Calcium plays an important role as a regulator of cellular function and metabolism. "The astrocytes were hyperactive. This means that calcium levels in these cells could suddenly rise. We also noted that this effect often travelled to neighbouring astrocytes, causing so-called calcium waves. The effect is quite similar to throwing a stone into water," Petzold notes. "Normal astrocytes, in contrast, only rarely exhibit these variations in the concentration of calcium."
Energy carriers with a signal effect
These fluctuations were caused by the actions of a cellular molecule named ATP. When the researchers blocked its release with the help of drugs, the activity of the astrocytes normalized. The same effect was achieved when the scientists disabled a specific receptor for these molecules. As Petzold's team determined, this receptor was present in unusually high numbers on the surface of astrocytes in the vicinity of plaques. This circumstance made the cells particularly susceptive.
"ATP and similar molecules normally supply the cells with energy. However, it has already been known that they can also act as messenger molecules that can trigger specific reactions", Petzold explains. "Although these molecules occur in most cell tissues, it is assumed that their release is increased in the vicinity of the plaques. We could show that this causes the astrocytes to switch into hyperactivity. The signalling pathway is mediated by a special receptor on the cell surface of astrocytes."
An influence on blood flow
It is still uncertain whether the astrocytes' hyperactivity constitutes a protective defence reaction or whether it is associated with negative consequences. However, the current study shows that the calcium waves may in some cases be associated with local changes in brain perfusion. "This is interesting, because there have long been indications that Alzheimer's has a vascular component. Alterations of blood vessels and blood flow appear to play an important role", says Petzold.
According to the Bonn scientist the current study could open up new avenues for therapy: "Our investigations demonstrate that it is possible to mitigate the hyperactivity of these cells. This could point to a novel approach for treatment. It might perhaps also be possible to modify the course of the disease with the help of suitable pharmaceuticals."
So far, the scientist clarifies, the signalling pathways were studied at the level of the cellular network in the brain. In future studies, Petzold and his colleagues intend to investigate what effect the inhibition of hyperactivity has on disease symptoms. | {
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JONESBORO,
Ark. (3/6/13) – Arkansas State University’s Sharika Nelvis will be on the national stage this weekend (March
8-9) as a result of qualifying for the 2013 NCAA Indoor Track and Field Championships.
The
2013 NCAA-I Championships, which are being hosted by the University of
Arkansas, will be held at the Randal Tyson Track Center on the UA campus in Fayetteville, Ark.
Nelvis,
the 2013 Sun Belt Conference’s (SBC) Most Outstanding Women’s Indoor Track Performer, will be competing in the
long jump and 200-meter dash at nationals.
The ASU junior is presently seeded 13th in the long jump at 6.32 meters
(20-7.35) and clocked a 23.38 time in the 200-meters to claim a present 11th
seeding.
“We
are certainly pleased with Sharika qualifying for the NCAA indoor meet,” said
ASU head coach Jim Patchell. “For the second year in a row, Sharika has
qualified in both the long jump and 200-meter events. Last year, she qualified in the 60-meter
hurdles and although the hurdles is probably her main event, we have changed a
few things about her hurdles race. She
hasn’t quite got it yet, but she’s very close much like a golfer making a swing
change."
Nelvis,
a three-time (1/9, 1/30 and 2/13) SBC Indoor Track Athlete of the Week pick this season,
was the 2013 SBC Women’s Indoor Track
Championships’ top scorer with 40.5 points and led the Red Wolves to the 2013
Sun Belt Indoor Championship title. She was
crowned the meet champion in four events – long jump, 55-meter hurdles,
55-meter dash, and 200-meter dash to claim first-team All-Sun Belt recognition.
“Sometimes
you have to take a step back in order to make a leap forward,” Patchell
said. “However, qualifying in events
that aren’t necessarily her focus does say a lot about her talent and work
ethic. We’re excited to see how things
pan out this weekend.”
A
season ago, Nelvis garnered U.S. Track and Field/Cross Country Coaches
Association (USTFCCCA) Second-Team All-America honors as a result of her
performance and participation in the 2012 NCAA Indoor Championships in Nampa,
Idaho. Nelvis competed in the 60-meter
hurdles, placing sixth in the first heat and then claiming ninth overall in the
qualifiers to miss the finals. Nelvis
ran a time of 8.18 in the event which was only .02 seconds in back of the
eighth-place and final qualifier.
The 2013 NCAA-I Indoor Track and Field Championships will be streamed live by ESPN3.com this Friday (March 8), beginning
at 5:25 p.m. (CT) and this Saturday (March 9), starting at 5:50 p.m. (CT).
Early portions of the meet not covered by ESPN3 will be streamed at NCAA.com
and ArkansasRazorbacks.com, beginning with the start of competition each day. A
tape-delay broadcast of the national meet will air Sunday, March 17, at 6 p.m. (CT)
on ESPNU.
For tickets to the 2013 NCAA-I Indoor Track Championships, fans can log on
to the online ticket center at ArkansasRazorbacks.com or call 800-982-HOGS
(4647) | {
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Internal combustion engines produce exhaust gases as a byproduct of the combustion process. In general, exhaust gases are expelled through an exhaust manifold which is designed to collect exhaust gases from one or more cylinders. The exhaust manifold is connected to an exhaust pipe which communicates exhaust gases into the open air. Internal combustion engines suffer from common drawbacks associated with the use of exhaust systems. In particular, exhaust gases which move through bends and past obstructions within exhaust pipes, mufflers, and/or catalytic converters serve to reduce the performance (i.e., lower peak engine power, lower gas mileage) of the engine by creating back pressures. Therefore, reducing back pressures within the exhaust system causes the engine to operate more efficiently, provides enhanced performance, and increases the gas mileage of an internal combustion engine.
Previous attempts to reduce back pressure within exhaust systems include removing or modifying the exhaust muffler. However, such attempts are replete with drawbacks. For example, removing the exhaust muffler eliminates one source of the back pressure, but also results in non-desirous engine noise. Other attempts to reduce back pressure within exhaust systems include positioning of a turbine within the exhaust pipe to draw the exhaust gases from the exhaust pipe. The internal turbine may be powered by the motion of the exhaust gases or be powered by a power source, such as an electric motor within the exhaust system. However, internal turbines powered by exhaust gases alone produce little effect. The efficiency of an internal turbine may be increased if the internal turbine is powered by an electric motor; however, electric motors operating within an exhaust pipe are subjected to high temperatures and corrosive effects from exhaust gases passing through the exhaust pipe. Electric motors operating in high temperature environments suffer from increased wear and tear and therefore require more frequent maintenance.
In other attempts to reduce the back pressure of an exhaust system, an external turbine is positioned such that the blades of the external turbine are disposed about the exhaust pipe near the discharge end of the exhaust pipe. While use of an external turbine has met with success, this design can limit the air flow that reaches the external turbine due to the obstruction of air flow by the exhaust pipe itself. Further, the amount of surface area of the blades available for receiving air flow is reduced for a turbine having a selected diameter due to the space filled by the exhaust pipe, thereby lowering efficacy of the system.
Therefore, a need exists for an exhaust evacuation apparatus that reduces the back pressure of an exhaust system, and improves the efficiency and performance of an associated internal combustion engine while avoiding the drawbacks of the previous systems. It is to such an exhaust evacuation apparatus that the present invention is directed. | {
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August 27, 2008
10:00 AM (EDT)
News Release Number: STScI-2008-32
A Clash of Clusters Provides New Clue to Dark Matter
August 27, 2008: A powerful collision of galaxy clusters has been captured by NASA’s Hubble
Space Telescope and Chandra X-ray Observatory. The observations of the
cluster known as MACS J0025.4-1222 indicate that a titanic collision has
separated the dark from ordinary matter and provide an independent
confirmation of a similar effect detected previously in a target dubbed
the Bullet Cluster. These new results show that the Bullet Cluster is
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do you think there is life after death? you're the expert
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The Ohio-Kentucky-Indiana Regional Council of Governments wants to hear from people and groups who bicycle in Cincinnati as it begins updating its Bike Route Guide map. OKI is asking for comments, ideas and questions about the current map.
"It was last updated in 2010," said OKI Senior Planner Don Burrell. "It's fairly popular with cyclists and gets distributed through our office and a number of bike shops."
The update will give the Cincinnati bicycle community the opportunity to comment on changes along routes, detours and safety issues. Burrell said the input will be used to help finalize the new map. He said it's being released in May for National Bike Month.
The campaign runs until February 17. Here's the link for comments. | {
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Protecting her riding
MHA supports independent, external review of hydraulic fracturing
Wayne Hounsell is pleased to see yet more support from another politician on calls for an independent, external review of hydraulic fracturing.
Judy Foote, MP for Random-Burin-St. George’s, said in a letter to Hounsell that she agrees the Government of Newfoundland and Labrador’s decision to freeze further fracking applications is a positive step.
It was in early November 2013 that Natural Resources Minister Derrick Dalley declared a moratorium on fracking in the province. He announced government will not approve fracking onshore or onshore-to-offshore pending further review. Dalley said government would hold public consultations before it develops any policy for fracking.
“I think an independent, external review would be better suited to provide the information necessary to make informed decisions about the use of fracking because of the ongoing controversy over the practice,” Foote said in the letter.
She said she cannot support the use of the process if there exists the possibility it can cause significant harm to the health of those who live in the area where it would occur, and to the environment.
Foote said exploration of shale gas reservoirs through hydraulic fracturing requires a significant amount of water with chemical additives and sand that could lead to contamination of water sources and habitat fragmentations.
She also read of other environmental concerns resulting from air emissions, the disposal of wastewater and infrastructure requirements.
Hounsell, the chairman of the Port au Port/Bay St. George Fracking Awareness Group, appreciated the MP’s support of the group’s position.
“We know she has a concern for the environment in western Newfoundland,” he said.
Hounsell said Foote joins a rather large group that has come out in support of their position, including Liberal Leader Dwight Ball, NDP Leader Lorraine Michael and Lana Payne, Atlantic director of Unifor, the largest energy union in Canada.
The Newfoundland and Labrador Federation of Labour has also approved of a moratorium on hydraulic fracturing at its convention back on Dec. 3, 2013.
Hounsell said he also heard from Charlene Fitzgerald, president of the Newfoundland and Labrador College of Family Physicians, who has pledged support.
“Our group is building a large base of support for western Newfoundland in favour of having an independent, external review carried out on hydraulic fracturing,” he said. | {
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Et principielt »ja tak« til højhuse i Nordhavnsområdet kan betyde, at Vesteuropas højeste bygning på 330 meter med hotel, shoppingcenter og beboelse eller en 280 meter høj skyskraber med en omkringliggende H.C. Andersen-tematiseret forlystelsespark bygges ved Oceankaj i den nye bydel i Københavns Nordhavn.
Et af de to højtragende byggerier er rykket et skridt nærmere realisering, efter et bredt flertal i Teknik- og Miljøudvalget og Økonomiudvalget i Københavns Kommune har vedtaget, at der skal arbejdes videre med udviklingen af højhus-projekterne.
Teknik- og Miljøforvaltningen og Økonomiforvaltningnen havde ellers anbefalet en afvisning af de to projekter, da de bryder afgørende med de planer, der i øjeblikket findes for udbygningen af Nordhavn. | {
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Silence-breathing-snore classification from snore-related sounds.
Obstructive sleep apnea (OSA) is a highly prevalent disease in which upper airways are collapsed during sleep, leading to serious consequences. Snoring is the earliest symptom of OSA, but its potential in clinical diagnosis is not fully recognized yet. The first task in the automatic analysis of snore-related sounds (SRS) is to segment the SRS data as accurately as possible into three main classes: snoring (voiced non-silence), breathing (unvoiced non-silence) and silence. SRS data are generally contaminated with background noise. In this paper, we present classification performance of a new segmentation algorithm based on pattern recognition. We considered four features derived from SRS to classify samples of SRS into three classes. The features--number of zero crossings, energy of the signal, normalized autocorrelation coefficient at 1 ms delay and the first predictor coefficient of linear predictive coding (LPC) analysis--in combination were able to achieve a classification accuracy of 90.74% in classifying a set of test data. We also investigated the performance of the algorithm when three commonly used noise reduction (NR) techniques in speech processing--amplitude spectral subtraction (ASS), power spectral subtraction (PSS) and short time spectral amplitude (STSA) estimation--are used for noise reduction. We found that noise reduction together with a proper choice of features could improve the classification accuracy to 96.78%, making the automated analysis a possibility. | {
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Note: Citations are based on reference standards. However, formatting rules can vary widely between applications and fields of interest or study. The specific requirements or preferences of your reviewing publisher, classroom teacher, institution or organization should be applied.
Hidden in plain sight : how to create extraordinary products for tomorrow's customers
Who are your next customers - not just the ones you are serving today but the ones you'll need three, five, ten years from now? How do you figure out what goods and services will attract them in the future? How do you figure this out ahead of your competitors? This title shows us how to see the world differently.
Details
Crossing state (of mind) lines --
The social lives of everyday objects --
Riding the waves of the past, present, and future --
You are what you carry --
Calibrating your cultural compass --
A matter of trust --
Finding the essence --
The great tradeoff --
Conclusion.
Responsibility:
Jan Chipchase and Simon Steinhardt.
Abstract:
Who are your next customers - not just the ones you are serving today but the ones you'll need three, five, ten years from now? How do you figure out what goods and services will attract them in the future? How do you figure this out ahead of your competitors? This title shows us how to see the world differently.Read more... | {
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1. In a saucepan, mix 300 ml of champagne or sparkling wine with sugar and gelatin. Leave for 2 minutes to gelatin soaking. Put the saucepan on a small fire and cook for 2-3 minutes, stirring constantly, until gelatin is completely dissolved.
2. Remove from the heat and pour the remaining 150 ml of champagne or sparkling wine. Mix well. Transfuse liquid into molds for baking (pre-each can be laid out on the cherry cocktail or frozen) and put in the freezer for at least 1 hour.
3. To get jelly, dip the form in warm water and gently stroll along the wall with a knife. Then gently turn over form. Cut the jelly with a sharp knife into small squares. Sprinkle with sugar. | {
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Q:
Background svg image doesn't work in ::before pseudo element
I'm having an issue trying to apply a svg background image to the ::before pseudo element of another element.
The problem is that the image is just not showing up. When I check out the element in the browser tools, there's no ::before pseudo element at all.
Here's my HTML:
<section class="spotlight">
<div class="container">
<div class="row">
<p>Lorem ipsum dolor sit amet, etiam lorem adipiscing elit.</p>
</div>
</div>
</section>
And my CSS:
.spotlight {
background-color: #4c5c96;
}
.spotlight::before {
background: url("data:image/svg+xml;utf8,<svg xmlns='http://www.w3.org/2000/svg' width='30' height='30'><circle cx='15' cy='15' r='10' /></svg>") no-repeat;
}
I have a fiddle here: https://jsfiddle.net/fcwp29qw/
The problem isn't with the pseudo element, I can add content to ::before and it works fine: https://jsfiddle.net/fcwp29qw/1/
There also isn't a problem with the background image format, I can add it to the element itself instead of ::before and it works: https://jsfiddle.net/fcwp29qw/2/
So what am I doing wrong here?
A:
You can try this
.spotlight {
background-color: #4c5c96;
position : relative;
}
.spotlight::before {
position : absolute;
content: '';
background: url("data:image/svg+xml;utf8,<svg xmlns='http://www.w3.org/2000/svg' width='30' height='30'><circle cx='15' cy='15' r='10' /></svg>") no-repeat;
}
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Saw the HKTrampers website this morning and remembered that they were going to my favorite part of Hong Kong (well, favorite after Sharp Peak and Plover Cove). So, make that 3rd favorite part of Hong Kong – Wong Lung Hang waterfalls. So, carried my camera for a change and decided to take it easy (at least for the first half).
Getting to Wong Lung Hang is easy. It’s walkable from Tung Chung station and takes about 15 minutes from there to get to the starting point (you can see the Garmin page for the map – link below). From there, there’s a lot of hopping over boulders and you eventually get to a beautiful waterfall.
Ready for action
The group
Waterfalls
There was too much demand for real estate by the main waterfalls so decided to go up a bit and found a private pool to occupy. After chilling for a while in the pools, it was time to undo all the “take it easy” stuff and so decided to go full throttle to Mui Wo. Enthusiasm was great but as usual sense of direction was not. Could not find the trail up to Lin Fa Shaan but after going in some random direction and heading back, the trail suddenly appeared in front of my eyes! Wasn’t too easy going up to 715m from 250m but wasn’t that incredibly tough either.
From there a straight run down to Mui Wo in about 30 minutes or so concluded the hike. (Dejavu from yesterday). Took a total of 1 hour 30 minutes from the waterfalls to get to Mui Wo ferry pier.
Now, for HK Capitalism 101.
ICC, The Arch, The Cullinan and co.
They say success leaves clues and the clues these beautiful buildings have left is that one owner has built all the 3 of them. Sun Hung Kai Properties. ICC is already attracted all the big financial giants (Morgan Stanley, Credit Suisse, Deutsche Bank and co.) This area will probably become like Central in the next couple of years.
Masterpiece and First Ferry
New World Development has built the Masterpiece (nice name) and they also own the First Ferry brand. They keep advertising First Ferry services on the ferry’s TVs YET have a monopoly on that route!
And finally, here’s Ocean Terminal in TST.
Ocean Terminal
This place is special because if you bring the word’s top 100 dirtiest, fattest pigs and have them all fart in Ocean Terminal, the interior of the building WILL STILL smell nice! That’s because this place hosts all the high end perfume/make up brands that HK has to offer.
So, after a nice long hike, I don’t have to worry about how much I stink as I am walking home through Ocean Terminal…
20-something Trampers showed up today for a day of waterfall exploration. There were several new faces too, including combat-ready Kevin from the UK, who had evidently paid utmost attention to the Tramper rucksack details listed on the website. He was wearing camouflage pants, had sturdy waterproof hiking boots on and several pouches containing life-saving equipments like a torch were attached to his belt.
We left at 10.45 AM to embark on a 20-minute walk that led to the base of the stream. As we approached the stream, the fragrant smell of fresh stream water hit our noses and the sound of the water hitting against the boulders intensified.
Shoes and socks came off and many of us immersed our bare feet in the purifying stream water. We were all like children in nature’s playground as we hopped from one boulder onto another in order to reach the Wong Lung Hang waterfalls. The water current was very strong because of the previous day rains and there were several challenging boulder hops on the course to the waterfalls. While the gentlemen offered their helping hands to those who needed, Francis seized on this opportunity to help a beautiful lady Tramper by giving her a Stream Hiking 101 lesson. In fact, we could hear the conversation. It went something like this:
After 2 minutes, I could hear her say “But we should have gone THAT way!”
About one grueling hour later, we reached the mesmerizing waterfalls. Many of us simply couldn’t resist a dip in the enticing water. At this point Francis approached me with an unusual request. He wanted me to buy some very unique cloth made of jute from my upcoming trip to India. He came to me bringing a cigarette lighter and a piece of cloth. That conversation went something like this.
Francis: You see, this is a genuine cloth made of jute. Can you observe the natural color? Feel the cloth. (He then brings another cloth for comparison). Now, this is artificial. If I burn it, you’ll notice that the strands turn black and the feeling will be of burnt plastic. That’s why it is artificial.
Arianna, who was sitting 2 rocks away, came closer to me and confessed her curiosity. She felt the specimen cloth too.
“Is this guy in the fashion industry?” she asked in amazement.
As I burst into laughter, I asked her to look at his green shorts, his unusual hat and rethink her question. She then retorted “You know you can get a lot of strange guys in the fashion industry”.
A refreshing swim and a couple of group photos later, Dominic and I were off to high speed yet exhausting finish. | {
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Q:
Symbolically Minimizing Expression with Multiple Piecewise Functions
Following up my previous question about ArgMin, I now face a situation where the solution to an ArgMin call, where the output is rewritten / partly solved.
The code leading to the problem is very long and messy and I hope that someone has encountered this before and can tell me under what circumstances this happens in general without needing the specific example?
Update 1
As requested, some sample code. I do not know of a shorter, more synthesized version of the problem, unfortunately.
Remove["Global`*"]
$Assumptions = _Symbol \[Element] Reals;
f[x_, u_] := x + u
v[x_, w_] := (x - w)^2
u[x_, b1_, b2_, f_, v_] :=
Module[{x1},
ArgMin[(x1 = f[x, uMin]; v[x1, b1] + v[x1, b2]), uMin, Reals]]
uConstrained[x_, b1_, b2_, f_, v_] :=
Module[{x1},
ArgMin[{(x1 = f[x, uMin]; v[x1, b1] + v[x1, b2]), -1 <= uMin <= 1},
uMin, Reals]]
p[x_, b1_, b2_, f_, u_, v_] := v[f[x, u[x, b1, b2, f, v]], b2]
c[b11_, b12_, f_, u_, v_, p_, up_] := Module[{u0, x1, u1, x2}, (
u0 = FullSimplify[u[x0, b11, b21, f, v]];
x1 = FullSimplify[f[x0, u0]];
u1 = FullSimplify[u[x1, b12, b22, f, v]];
x2 = FullSimplify[f[x1, u1]];
FullSimplify[v[x1, w1]] +
FullSimplify[p[x0, b11, b21, f, up, v]] +
FullSimplify[v[x2, w2]] +
FullSimplify[p[x1, b12, b22, f, up, v]])]
ArgMin[FullySimplify[c[b11, b12, f, uConstrained, v, p, u]], {b11, b12}, Reals]
A:
Edit, taking advantage of improvements to the code in the question and using PiecewiseExpand in the answer.
The quantity to be minimized, c[b1, b2, f, uConstrained, v, p, u], contains two distinct Piecewise functions, one with three regions in {x0, b21, b22, b1, b2} space, and the other with five regions. ({w1, w2} do not appear in the range definitions.) It can be converted into a single Piecewise function of ten expressions and regions, to each of which ArgMin can be applied in turn. Then, finding the minimum of the ten minimums would, in principle, give the desired result.
onepw = PiecewiseExpand[c[b1, b2, f, uConstrained, v, p, u]] // FullSimplify
(* Piecewise[
{{1/2 (b1^2 + b2^2 + b21^2 + b22^2) - (b1 + b21) w1 + w1^2 - (b2 + b22) w2 + w2^2,
-2 < b1 - b2 + b21 - b22 <= 2 && -2 < b1 + b21 - 2 x0 <= 2},
{1/4 ((b1 - b21)^2 + (b2 - b22)^2 + (b1 + b21 - 2 w1)^2 + (b1 + b21 - 2(1 + w2))^2),
-2 < b1 + b21 - 2 x0 <= 2 && ((2 + b1 + b21 > b2 + b22 && 4 + b2 + b22 < 2 x0) ||
b1 + b21 > 2 + b2 + b22)},
{1/4 ((b1 - b21)^2 + (b2 - b22)^2 + (b1 + b21 - 2 w1)^2 + (2 + b1 + b21 - 2 w2)^2),
2 + b1 + b21 <= b2 + b22 && -2 < b1 + b21 - 2 x0 <= 2},
{1/4 ((b1 - b21)^2 + (b2 - b22)^2 + (b2 + b22 - 2 w2)^2 + 4 (1 - w1 + x0)^2),
b1 + b21 > 2 + 2 x0 && 0 < b2 + b22 - 2 x0 <= 4},
{1/4 (b1 - b21)^2 + 1/4 (b2 - b22)^2 + (w2 - x0)^2 + (1 - w1 + x0)^2,
b1 + b21 > 2 + 2 x0 && b2 + b22 <= 2 x0},
{1/4 (b1 - b21)^2 + 1/4 (b2 - b22)^2 + (1 - w1 + x0)^2 + (2 - w2 + x0)^2,
b1 + b21 > 2 + 2 x0 && b2 + b22 > 4 + 2 x0},
{1/4 ((b1 - b21)^2 + (b2 - b22)^2 + (b2 + b22 - 2 w2)^2 + 4 (1 + w1 - x0)^2),
(-4 < b2 + b22 - 2 x0 <= 0 && 2 + b1 + b21 <= 2 x0) || (0 < b2 + b22 - 2 x0 <= 4 &&
b1 + b21 > 2 + 2 x0) || (-2 < b1 + b21 - 2 x0 <= 2 &&
-2 < b1 - b2 + b21 - b22 <= 2)},
{1/4 (b1 - b21)^2 + 1/4 (b2 - b22)^2 + (1 + w1 - x0)^2 + (w2 - x0)^2,
(-2 < b1 + b21 - 2 x0 <= 2 && 2 + b1 + b21 <= b2 + b22) || (b1 + b21 > 2 + 2 x0 &&
b2 + b22 <= 2 x0) || (2 + b1 + b21 <= 2 x0 && b2 + b22 > 2 x0)},
{1/4 (b1 - b21)^2 + 1/4 (b2 - b22)^2 + (1 + w1 - x0)^2 + (2 + w2 - x0)^2,
(-2 < b1 + b21 - 2 x0 <= 2 && ((2 + b1 + b21 > b2 + b22 && 4 + b2 + b22 < 2 x0) ||
b1 + b21 > 2 + b2 + b22)) || (2 + b1 + b21 <= 2 x0 && 4 + b2 + b22 <= 2 x0) ||
(b1 + b21 > 2 + 2 x0 && b2 + b22 <= 2 x0)}},
1/4 ((b1 - b21)^2 + (b2 - b22)^2 + (b2 + b22 - 2 (2 + w2))^2 + 4 (1 + w1 - x0)^2)] *)
Unfortunately, minimizing the first of these ten expressions,
ArgMin[onepw[[1, 1]], {b1, b2}]
produces a Piecewise answer with a LeafCount of 830699 (in about 15 minutes), and Simplify runs for hours (twenty-one before I terminated that computation) without returning a result. Presumably, minimizing the other nine expressions produces similarly enormous results. The reason for the enormous results returned by ArgMin is that the regions over which any of the ten expressions is valid are complex shapes in the five-dimensional space of parameters and solutions, and those shapes change with the values of the parameters. So, there are an enormous number of case to be considered.
A more practical approach is to define the function,
sol[x0t_, w1t_, w2t_, b21t_, b22t_] :=
ArgMin[Simplify[c[b1, b2, f, uConstrained, v, p, u],
x0 == x0t && w1 == w1t && w2 == w2t && b21 == b21t && b22 == b22t],
{b1, b2}, Reals]
which usually can produce the answer for a given set of parameters in several seconds. For instance,
sol[5/2, E, Pi, -7, 1.11]
(* {-7., 3.14159} *)
or
sol[19, 70, -71, 86, 19]
(* {86, 19} *)
Interestingly,
Count[Table[param = RandomInteger[{-300, 300}, 5];
param[[4 ;; 5]] == sol @@ param, 100], True]
suggests that {b1, b2} == {b21, b22} is the answer roughly 90% of the time.
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Dennis Martínez National Stadium
Dennis Martínez National Stadium () is located in Managua, Nicaragua. It has a capacity of 15,000 and it was named after former MLB player Dennis Martínez.
The original stadium was built in 1948 and is Nicaragua's national stadium. It is used mainly for baseball but also serves as a venue for concerts, boxing, football, religious events and had a capacity of 30,100 people. It is the home stadium of Indios del Bóer baseball team and Deportivo Walter Ferretti football team. Inside the stadium is a hall of fame near the entrance showing medals, cups, photos and memories of Nicaraguan players. There is also a gym located inside.
Renaming
The stadium has been renamed three times. Built in 1948, it was originally named "El Estadio Nacional" (The National Stadium). After the 1972 earthquake that struck Managua and destroyed 90% of the city, it was rebuilt and renamed after Anastasio Somoza García. In 1979, after the Sandinistas overthrew the Somoza dynasty, it was renamed in honor of Rigoberto López Pérez, the man who, in 1956, assassinated Anastasio Somoza García. On November 20, 1998, the 50th anniversary of the founding of the stadium, then-President Arnoldo Alemán issued a decree changing the stadium's name to Estadio Nacional Dennis Martínez. Dennis Martínez, born in 1955 (several years after this stadium had opened), was Major League Baseball's first Nicaraguan-born player.
New Dennis Martinez National Stadium
The new Dennis Martinez National Stadium has been under construction since 2016 and was completed in October, 2017. The first sport event in the stadium was the Baseball series of three games between Nicaragua & Chinese Taipei in October 20-22, 2017. It will play host to the Central American Games, scheduled to take place December 3 to December 17, 2017. The stadium, located near the Tiscapa lagoon, is approximately 3 kilometers southeast of the original stadium. It was designed by Dynamica and will seat 15,000, with the capability to expand to 20,000. In addition, the berm field will accommodate 4,000 spectators. The field will meet Major League Baseball specifications and could potentially host a Major League game. Lately and sadly this stadium have been used by dictator Daniel Ortega and the national police as a military center to kill students from universities who protests again the dictator Ortega.
See also
Nicaragua
Culture of Nicaragua
References
External links
Instituto Nicaragüense de Juventud y Deporte
World Stadiums page
Fussballtempel.net - Photo gallery
Category:Athletics (track and field) venues in Nicaragua
Category:Baseball venues in Nicaragua
Category:Football venues in Managua
Nicaragua
Category:Sports venues completed in 1948
Category:Buildings and structures in Managua
Category:Tourist attractions in Managua | {
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util-deprecate
==============
### The Node.js `util.deprecate()` function with browser support
In Node.js, this module simply re-exports the `util.deprecate()` function.
In the web browser (i.e. via browserify), a browser-specific implementation
of the `util.deprecate()` function is used.
## API
A `deprecate()` function is the only thing exposed by this module.
``` javascript
// setup:
exports.foo = deprecate(foo, 'foo() is deprecated, use bar() instead');
// users see:
foo();
// foo() is deprecated, use bar() instead
foo();
foo();
```
## License
(The MIT License)
Copyright (c) 2014 Nathan Rajlich <[email protected]>
Permission is hereby granted, free of charge, to any person
obtaining a copy of this software and associated documentation
files (the "Software"), to deal in the Software without
restriction, including without limitation the rights to use,
copy, modify, merge, publish, distribute, sublicense, and/or sell
copies of the Software, and to permit persons to whom the
Software is furnished to do so, subject to the following
conditions:
The above copyright notice and this permission notice shall be
included in all copies or substantial portions of the Software.
THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND,
EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES
OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND
NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT
HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY,
WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING
FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR
OTHER DEALINGS IN THE SOFTWARE.
| {
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What Do Customers Buy Together With This Item?
The Ugoos UM3 TV Box has an Android 4.4 + Ubuntu operating system, a RK3288 28nm Cortex-A17 Quad Core CPU, 2GB of RAM as well as 8GB of Internal Memory.
Ugoos UM3 TV Box
There are so many Android TV boxes on the market that it has become difficult to differentiate, so Ugoos has decided to support not only Android 4.4 like all their competitors, but also Ubuntu, and they’ve provided an alpha release of dual boot Android / Ubuntu images for Ugoos UM3 models.
This TV box has Bluetooth connectivity so you can quickly connect with other devices. There is dual Wi-Fi band plus this TV box supports DLNA amd Miracast so you can make a strong connection between compatible devices. Ugoos has made sure this TV box can also support 2.4GHz wireless air mouse or remote controllers.
There are several ports on the TV box including a micro SD card slot that supports cards of up to 32GB, an AV out, and two USB ports to allow for many diverse ways to connect and view media.
Boasting a RK3288 28nm Cortex-A17 Quad Core processor and a dedicated Quad-Core Mali-T764 GPU, this TV box will stream all video content perfectly and even supports various media files including MPEG-4, H.263, H.264, AVS, VC-1, Sorenson Spark and MVC formats. Backing up the 1.8GHz CPU is 2GB of RAM to ensure there is no lagging in the performance when streaming videos or engaging in apps. Transform your television today with the incredible UM3 by Android TV box specialists, Ugoos.
Ubuntu + Android 4.4 OS
When you turn on this TV box, you will enter the Ubuntu operating system, from there you can decide whether to stay with the Ubuntu system or switch to the Android 4.4 operating system. Ubuntu is a Debian-based Linux operating system and is one of the most secured operating system and defines the highest level of security as compared to other operating system. A major advantage is that Ubuntu is an open source platform.
Android 4.4 is a super popular operating system that has been given the nickname KitKat and has been designed to be a huge improvement on previous versions. With a faster performance and being more efficient when performing multiple tasks, Android really benefits this quad core TV box
This product is in stock now, we guarantee next working day shipping and offer a 12 months warranty on all our products. Brought to you by the leader in electronic devices and wholesale Android TV boxes, Chinavasion.
Weight/dimension is for the main item of this boxed product, to help you compare product sizes before buying: please do not base your shipping calculations on this price - shipping prices depend on your cart contents, shipping destination, and shipping method: please use the checkout to select options and preview shipping price for your total order. | {
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#
# DEPRECATED: implementation for ffi.verify()
#
import sys, os, binascii, shutil, io
from . import __version_verifier_modules__
from . import ffiplatform
from .error import VerificationError
if sys.version_info >= (3, 3):
import importlib.machinery
def _extension_suffixes():
return importlib.machinery.EXTENSION_SUFFIXES[:]
else:
import imp
def _extension_suffixes():
return [suffix for suffix, _, type in imp.get_suffixes()
if type == imp.C_EXTENSION]
if sys.version_info >= (3,):
NativeIO = io.StringIO
else:
class NativeIO(io.BytesIO):
def write(self, s):
if isinstance(s, unicode):
s = s.encode('ascii')
super(NativeIO, self).write(s)
class Verifier(object):
def __init__(self, ffi, preamble, tmpdir=None, modulename=None,
ext_package=None, tag='', force_generic_engine=False,
source_extension='.c', flags=None, relative_to=None, **kwds):
if ffi._parser._uses_new_feature:
raise VerificationError(
"feature not supported with ffi.verify(), but only "
"with ffi.set_source(): %s" % (ffi._parser._uses_new_feature,))
self.ffi = ffi
self.preamble = preamble
if not modulename:
flattened_kwds = ffiplatform.flatten(kwds)
vengine_class = _locate_engine_class(ffi, force_generic_engine)
self._vengine = vengine_class(self)
self._vengine.patch_extension_kwds(kwds)
self.flags = flags
self.kwds = self.make_relative_to(kwds, relative_to)
#
if modulename:
if tag:
raise TypeError("can't specify both 'modulename' and 'tag'")
else:
key = '\x00'.join([sys.version[:3], __version_verifier_modules__,
preamble, flattened_kwds] +
ffi._cdefsources)
if sys.version_info >= (3,):
key = key.encode('utf-8')
k1 = hex(binascii.crc32(key[0::2]) & 0xffffffff)
k1 = k1.lstrip('0x').rstrip('L')
k2 = hex(binascii.crc32(key[1::2]) & 0xffffffff)
k2 = k2.lstrip('0').rstrip('L')
modulename = '_cffi_%s_%s%s%s' % (tag, self._vengine._class_key,
k1, k2)
suffix = _get_so_suffixes()[0]
self.tmpdir = tmpdir or _caller_dir_pycache()
self.sourcefilename = os.path.join(self.tmpdir, modulename + source_extension)
self.modulefilename = os.path.join(self.tmpdir, modulename + suffix)
self.ext_package = ext_package
self._has_source = False
self._has_module = False
def write_source(self, file=None):
"""Write the C source code. It is produced in 'self.sourcefilename',
which can be tweaked beforehand."""
with self.ffi._lock:
if self._has_source and file is None:
raise VerificationError(
"source code already written")
self._write_source(file)
def compile_module(self):
"""Write the C source code (if not done already) and compile it.
This produces a dynamic link library in 'self.modulefilename'."""
with self.ffi._lock:
if self._has_module:
raise VerificationError("module already compiled")
if not self._has_source:
self._write_source()
self._compile_module()
def load_library(self):
"""Get a C module from this Verifier instance.
Returns an instance of a FFILibrary class that behaves like the
objects returned by ffi.dlopen(), but that delegates all
operations to the C module. If necessary, the C code is written
and compiled first.
"""
with self.ffi._lock:
if not self._has_module:
self._locate_module()
if not self._has_module:
if not self._has_source:
self._write_source()
self._compile_module()
return self._load_library()
def get_module_name(self):
basename = os.path.basename(self.modulefilename)
# kill both the .so extension and the other .'s, as introduced
# by Python 3: 'basename.cpython-33m.so'
basename = basename.split('.', 1)[0]
# and the _d added in Python 2 debug builds --- but try to be
# conservative and not kill a legitimate _d
if basename.endswith('_d') and hasattr(sys, 'gettotalrefcount'):
basename = basename[:-2]
return basename
def get_extension(self):
ffiplatform._hack_at_distutils() # backward compatibility hack
if not self._has_source:
with self.ffi._lock:
if not self._has_source:
self._write_source()
sourcename = ffiplatform.maybe_relative_path(self.sourcefilename)
modname = self.get_module_name()
return ffiplatform.get_extension(sourcename, modname, **self.kwds)
def generates_python_module(self):
return self._vengine._gen_python_module
def make_relative_to(self, kwds, relative_to):
if relative_to and os.path.dirname(relative_to):
dirname = os.path.dirname(relative_to)
kwds = kwds.copy()
for key in ffiplatform.LIST_OF_FILE_NAMES:
if key in kwds:
lst = kwds[key]
if not isinstance(lst, (list, tuple)):
raise TypeError("keyword '%s' should be a list or tuple"
% (key,))
lst = [os.path.join(dirname, fn) for fn in lst]
kwds[key] = lst
return kwds
# ----------
def _locate_module(self):
if not os.path.isfile(self.modulefilename):
if self.ext_package:
try:
pkg = __import__(self.ext_package, None, None, ['__doc__'])
except ImportError:
return # cannot import the package itself, give up
# (e.g. it might be called differently before installation)
path = pkg.__path__
else:
path = None
filename = self._vengine.find_module(self.get_module_name(), path,
_get_so_suffixes())
if filename is None:
return
self.modulefilename = filename
self._vengine.collect_types()
self._has_module = True
def _write_source_to(self, file):
self._vengine._f = file
try:
self._vengine.write_source_to_f()
finally:
del self._vengine._f
def _write_source(self, file=None):
if file is not None:
self._write_source_to(file)
else:
# Write our source file to an in memory file.
f = NativeIO()
self._write_source_to(f)
source_data = f.getvalue()
# Determine if this matches the current file
if os.path.exists(self.sourcefilename):
with open(self.sourcefilename, "r") as fp:
needs_written = not (fp.read() == source_data)
else:
needs_written = True
# Actually write the file out if it doesn't match
if needs_written:
_ensure_dir(self.sourcefilename)
with open(self.sourcefilename, "w") as fp:
fp.write(source_data)
# Set this flag
self._has_source = True
def _compile_module(self):
# compile this C source
tmpdir = os.path.dirname(self.sourcefilename)
outputfilename = ffiplatform.compile(tmpdir, self.get_extension())
try:
same = ffiplatform.samefile(outputfilename, self.modulefilename)
except OSError:
same = False
if not same:
_ensure_dir(self.modulefilename)
shutil.move(outputfilename, self.modulefilename)
self._has_module = True
def _load_library(self):
assert self._has_module
if self.flags is not None:
return self._vengine.load_library(self.flags)
else:
return self._vengine.load_library()
# ____________________________________________________________
_FORCE_GENERIC_ENGINE = False # for tests
def _locate_engine_class(ffi, force_generic_engine):
if _FORCE_GENERIC_ENGINE:
force_generic_engine = True
if not force_generic_engine:
if '__pypy__' in sys.builtin_module_names:
force_generic_engine = True
else:
try:
import _cffi_backend
except ImportError:
_cffi_backend = '?'
if ffi._backend is not _cffi_backend:
force_generic_engine = True
if force_generic_engine:
from . import vengine_gen
return vengine_gen.VGenericEngine
else:
from . import vengine_cpy
return vengine_cpy.VCPythonEngine
# ____________________________________________________________
_TMPDIR = None
def _caller_dir_pycache():
if _TMPDIR:
return _TMPDIR
result = os.environ.get('CFFI_TMPDIR')
if result:
return result
filename = sys._getframe(2).f_code.co_filename
return os.path.abspath(os.path.join(os.path.dirname(filename),
'__pycache__'))
def set_tmpdir(dirname):
"""Set the temporary directory to use instead of __pycache__."""
global _TMPDIR
_TMPDIR = dirname
def cleanup_tmpdir(tmpdir=None, keep_so=False):
"""Clean up the temporary directory by removing all files in it
called `_cffi_*.{c,so}` as well as the `build` subdirectory."""
tmpdir = tmpdir or _caller_dir_pycache()
try:
filelist = os.listdir(tmpdir)
except OSError:
return
if keep_so:
suffix = '.c' # only remove .c files
else:
suffix = _get_so_suffixes()[0].lower()
for fn in filelist:
if fn.lower().startswith('_cffi_') and (
fn.lower().endswith(suffix) or fn.lower().endswith('.c')):
try:
os.unlink(os.path.join(tmpdir, fn))
except OSError:
pass
clean_dir = [os.path.join(tmpdir, 'build')]
for dir in clean_dir:
try:
for fn in os.listdir(dir):
fn = os.path.join(dir, fn)
if os.path.isdir(fn):
clean_dir.append(fn)
else:
os.unlink(fn)
except OSError:
pass
def _get_so_suffixes():
suffixes = _extension_suffixes()
if not suffixes:
# bah, no C_EXTENSION available. Occurs on pypy without cpyext
if sys.platform == 'win32':
suffixes = [".pyd"]
else:
suffixes = [".so"]
return suffixes
def _ensure_dir(filename):
dirname = os.path.dirname(filename)
if dirname and not os.path.isdir(dirname):
os.makedirs(dirname)
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Am I the only one who doesn't have a fucking ship cup
125 shares | {
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1. Field of the Invention
The present invention relates to a connector capable of connecting, disconnecting or switching an electric signal.
2. Description of the Background Art
Recent semiconductor devices are rapidly integrated, to result in increasing importance of an inspection step for semiconductor devices. Referring to FIG. 7 showing a conventional inspection step, several stages of boards are arranged between a semiconductor device 127 to be inspected and a test head 121 provided with terminals of a tester. First, a motherboard 122 is arranged immediately above the test head 121. This motherboard 122 is provided with contacts arranged in response to the arrangement of the terminals on the test head 121, and remains unchanged regardless of the type of the semiconductor device 127 to be inspected. A female contact terminal (not shown) is provided on an upper portion of the motherboard 122, to be connected with a male contact terminal (not shown) provided on a lower portion of a performance board 124 located above the same by a cable 123.
The performance board 124 is formed by a plurality of boards. Connectors 110 are arranged between the boards forming the performance board 124. A contactor (test board) 125 is arranged on the performance board 124. Terminals 126 of the semiconductor device 127 to be inspected are directly connected to the test board 125. In general, a large number of semiconductor chips 127 are inspected at the same time. Assuming that each semiconductor chip 127 is formed with tens of terminals, therefore, the connectors 110 arranged between the boards forming the performance board 124 are provided with thousands of terminals, in order to simultaneously inspect hundreds of semiconductor chips 127.
The performance board 124 or a socket board is provided between the motherboard 122 and the semiconductor device 127 to be inspected, in order to attain connection with flexibility in response to the type of the semiconductor device 127 to be inspected and the performance to be inspected.
The present invention is directed to the connectors 110 employed for connecting the boards forming the aforementioned performance board 124 with each other, for example. The connectors 110 are provided with thousands of terminals as hereinabove described, and hence particular notice must be taken in order to reliably connect the terminals.
FIGS. 8 and 9 show the structure of each of the conventional connectors 110 employed for connecting the aforementioned boards forming the performance board 124 with each other. FIG. 9 is a sectional view taken along the line IXxe2x80x94IX in FIG. 8. The structure of the connector 110 is now described with reference to connection. First, a male connector 110a and a female connector 110b are mated with each other so that each male connector terminal 102 fixed to a male connector body 101 is located between each pair of female connector terminals 105 fixed to a female connector body. Then, connector terminal switching mechanism parts 107 press the female connector terminals 105 against the male connector terminal 102 for bringing the male and female connectors 110a and 110b into contact with each other, thereby attaining electrical contact.
Then, a push-up mechanism part 106 moves up to push up the male connector body 101. Thus, the male connector terminal 102 moves upward in the state frictionally in contact with the female connector terminals 105. The male and female connector terminals 102 and 105 must essentially be frictionally connected with each other in order to stably maintain electrical connection in an excellent state in a connector having a large number of pins, to which the present invention is directed. Such frictional connection between the connector terminals 102 and 105 is referred to as wiping operation or simply as wiping. A mechanism for this wiping operation is provided around the aforementioned connection part. Thus, a signal line connected to the male connector 110a can be electrically connected with a signal line connected to the female connector 110b.
In the aforementioned connector 110, the length of the connection part formed by the male and female connectors 110a and 110b is varied in wiping due to reciprocation of the male connector 110a. Therefore, the wiping mechanism provided around the aforementioned connection part must be so formed that the male connector 110a is reciprocative to vary the distance between the same and the female connector 110b. Consequently, the wiping mechanism provided around the connection part and other mechanism parts are complicated. Considering fluctuation of the width of the connector 110, a driving source such as a motor necessary for the wiping operation and a gear mechanism for transmitting the driving force must be arranged in an extremely complicated structure. In other words, the gear mechanism is complicated and the number of components for transmitting the driving force is increased. If the aforementioned reciprocation is unallowable, further, the type of the employed connector 110 must be limited.
In the aforementioned conventional connector 110, the signal lines connected to the male and female connector terminals 102 and 105 respectively are fixed in connectional association. In other words, the male and female connector terminals 102 and 105 must be connected or disconnected with or from each other while keeping fixed connectional association. Therefore, the aforementioned connectional association cannot be changed by mechanically operating the connector 110, for example.
A first object of the present invention is to provide a connector enabling wiping operation without changing the distance between a male connector and a female connector.
A second object of the present invention is to provide a connector capable of changing connectional association between a male connector terminal and a female connector terminal by mechanically operating the connector.
A connector according to a first aspect of the present invention comprises a male connector having a male connector body and a male connector terminal held by the male connector body, a female connector having a female connector terminal electrically connected with the male connector terminal and a female connector body holding the female connector terminal, a relay connector terminal movably mounted on either the male connector body or the female connector body, and a drive mechanism part bringing the relay connector terminal into contact with both of the male connector terminal and the female connector terminal and performing rubbing.
According to this structure, the distance between the male and female connectors may not be changed in wiping operation. Therefore, mechanism parts around the connector can be simplified. Further, height restriction against the used connector can be loosened. Each of the aforementioned drive mechanism part (wiping mechanism part) and a switching mechanism part described later is formed by a motor arranged around the connector and gears transmitting the driving force thereof. If the distance between the male and female connectors is varied, therefore, the arrangement of the aforementioned mechanisms is extremely complicated. Such complication of the mechanism parts around the connector can be relaxed due to the aforementioned structure. Consequently, components themselves can be simplified and the number of the components can be reduced. Further, the aforementioned mechanism parts can be improved in reliability and durability.
A connector according to a second aspect of the present invention comprises a male connector having a male connector body and at least two male connector terminals held by the male connector body and arranged along a prescribed direction and a female connector having at least two female connector terminals arranged along the same direction as the male connector terminals and a female connector body holding at least two female connector terminals. The connector also comprises a switching mechanism part inhibiting the male connector terminals and the female connector terminals from coming into electrical contact with each other in a first state and individually bringing the female connector terminals and the male connector terminals into electrical contact with each other when shifting from the first state to a second state. The connector further comprises a connection switching mechanism part rubbing either the male connector or the female connector with respect to the counterpart along the direction of arrangement of the connector terminals when the switching mechanism part is in the first state.
According to this structure, the male or female connector terminals can be displaced along the direction of arrangement thereof with no hindrance. Thus, the connector, i.e., a hard component, can switch the connectional relation. The connection switching mechanism part is formed by a mechanism similar to the aforementioned rubbing mechanism part. | {
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2000 Sanfrecce Hiroshima season
2000 Sanfrecce Hiroshima season
Competitions
Domestic results
J.League 1
Emperor's Cup
J.League Cup
Player statistics
Other pages
J. League official site
Sanfrecce Hiroshima
Category:Sanfrecce Hiroshima seasons | {
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Tranebergs Idrottsplats
Tranebergs Idrottsplats was a football stadium in Traneberg district, western Stockholm, Sweden. It was opened in September 1911. Tranebergs Idrottsplats served as the home ground of Djurgårdens IF for 25 seasons. Stadium was demolished in 1936.
1912 Summer Olympics
In 1912 Summer Olympics Tranebergs Idrottsplats hosted three football matches.
Matches
References
Category:Venues of the 1912 Summer Olympics
Category:Olympic football venues
Category:Football venues in Sweden
Category:Football venues in Stockholm
Category:1911 establishments in Sweden
Category:Sports venues completed in 1911
Category:Sports venues demolished in 1936
Category:1936 disestablishments in Sweden | {
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Rubén Marín
Rubén Hugo Marín (born May 1, 1934) is a former Argentine Senator for La Pampa Province. He was also a governor of the province on two occasions.
Marín, a lawyer by profession, is a member of the Argentine Justicialist Party.
Born in Trenel, Marín enrolled at the National University of La Plata, and graduated with a juris doctor in 1961. He was Peronist gubernatorial candidate Aquiles Regazzoli's running mate in 1973, and served as Vice Governor of La Pampa from 1973 to 1976. Marín was elected governor in 1983 upon the restoration of democracy, serving until 1987. He was then elected to the Argentine Chamber of Deputies, and two years later, to the Senate.
Voters returned Marín to the governor's post in 1991, and he was re-elected in 1995 and 1999. He was elected to the Senate in 2003; there, he joined the majority Front for Victory parliamentary group, supporting the national government of President Néstor Kirchner.
Marín unsuccessfully ran for a fifth term as governor in 2007, but was defeated in party primaries by the faction headed by Carlos Verna. Marín's term in the Senate expired on December 10, 2009.
External links
Senate profile
References
Category:1934 births
Category:Living people
Category:People from La Pampa Province
Category:National University of La Plata alumni
Category:Argentine lawyers
Category:Members of the Argentine Senate
Category:Justicialist Party politicians
Category:Governors of La Pampa Province
Category:Members of the Argentine Chamber of Deputies | {
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Characterizing the learning curve of MRI-US fusion prostate biopsies.
MRI-US fusion prostate biopsies are becoming a common procedure to diagnose prostate cancer. There is a paucity of information regarding the learning curve for fusion biopsies. We aim to study the amount of experience needed to be both accurate and time-efficient in this procedure. We prospectively collected data on all MRI-US fusion biopsies performed from April 2014 to August 2017. We used two parameters to define the learning curve. Process Measurement (efficiency) was measured by time from the beginning of anesthesia to end of procedure. Outcome Measurement (accuracy) was measured by cancer detection rate for PI-RAD 3 lesions. The end of the learning curve was defined graphically and mathematically. We performed a separate analysis for transrectal and transperineal biopsies. We completed 779 fusion biopsies (523 transrectal, 256 transperineal). Patients median age was 66 years (IQR 61-70) and median PSA 6.95 ng/ml (IQR 4.2-10.6). Prostate cancer was diagnosed in 385 (49%). Process Measurement-Procedure time decreased from 45 min in the first transrectal fusion biopsy to 15 min after 109 biopsies and remained stable (p < 0.0001). Time decreased from 55 min in the first transperineal biopsy to 18 min after 124 biopsies (p < 0.0001). Outcome Measurement-In transrectal fusion-biopsies detection rate for PI-RADS 3 lesions increased from 35 to 50% after 104 biopsies. In transperineal fusion-biopsies, detection rate increased from 40 to 55% after 119 cases for PI-RADS 3 lesions. We measured the learning curve of fusion biopsies graphically and mathematically. We demonstrated that proficiency occurs after 110 transrectal and 125 transperineal fusion-biopsies. | {
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The present invention is directed to the provision of a device and method for displaying biological materials, such as plants, which are to be viewed in a preserved state. It is important for teachers, botanists, store owners, home owners, and others, to be able to display materials, such as rare plants, in a container without worrying about the preservation of the material, and to display the material in a fashionable and attractive way which will attract notice and interest.
Display devices are known in the art for displaying articles needed to be preserved, in which a solution of alcohol and water is provided to preserve the material. However, such prior art units are relatively unattractive. Display devices are also known in other arts where, for example, lighting effects are to be achieved.
U.S. Pat. No. 3,535,805 provides for display of various shaped birefringent sheet forms freely suspended in a rotating liquid. Light is directed onto the forms and polarizing filters are located on opposite sides of the forms and in the path of light. Means are provided to rotate the liquid, thus causing the suspended forms to move and to provide a moving image on a wall or screen. However, this arrangement would not be suitable for the display of biological materials. It is complicated and cumbersome and is for enjoyment only. It has no educational value. | {
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Q:
Highcharts area charts with single data, not rendering
I have an area chart with three series x-axis is 'datetype', when there is only data in each series the labels on x and y axis appears as expected but the plot point is missing. Can't expect a filled area for one data but even the plot point is missing.
'minRange' property is set and so the label is showing the date from the data.
Is this expected or there is a property that needs to be set to see the plot points.
fiddle link here http://jsfiddle.net/bM9j9/6/
$(function () {
$('#container').highcharts({
chart: {
type: 'area'
},
title: {
text: 'Area chart'
},
xAxis: {
type: 'datetime',
minRange: 864e5
},
yAxis: {
min: 0
//tickInterval: 0.5,
//minRange: 0.5
},
credits: {
enabled: false
},
plotOptions: {
area: {
stacking: 'normal',
marker: {
enabled: false,
symbol: 'circle',
radius: 2,
states: {
hover: {
enabled: true
}
}
}
}
},
series: [{
name: 'Open',
data: [
[Date.UTC(2010, 0, 3), 120]
]
}, {
name: 'Closed',
data: [
[Date.UTC(2010, 0, 3), 60]
]
}, {
name: 'Accepted',
data: [
[Date.UTC(2010, 0, 3), 89]
]
}]
});
});
A:
actually the data is rendered, But you cannot see it because the marker radius of the point is 0 in normal sate but it will be visible when your mouse hovers on it.
this is happening because you have disabled marker and have enabled hover for it.
To get the points visible turn them on.
plotOption: {
area:{
marker: {
enabled: true,
-----continue with other properties----
}
}
}
updated your fiddle here: http://jsfiddle.net/bM9j9/7/
Hope this will help you.
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Among miners killed in a methane blast near the town of Karvina are 11 Polish nationals and two Czechs.
A methane explosion in a Czech coal mine has killed 13 miners, including 11 Polish nationals and two Czechs, the mine operator OKD said on Friday.
The state-run OKD company said a methane blast more than 800 metres (875 yards) underground devastated areas of the CSM hard-coal mine, near the town of Karvina, on Thursday.
“Due to yesterday’s mine disaster, 13 miners lost their lives – 11 Poles and two Czechs,” OKD spokesman Ivo Celechovsky said at a televised news conference.
The incident is the worst mining accident in the Czech Republic since 1990, when 30 miners died in a fire at a mine near Karvina, according to a list compiled by the CTK news agency.
OKD said most of the victims and injured were Polish miners provided by the ALPEX company.
OKD managing director Boleslav Kowalczyk said the search of the scene had had to be abandoned due to conditions in the shaft.
“Unfortunately, we have reached a point where it was impossible to move forward because there was a fire raging and zero visibility,” he said. | {
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Q:
Stored Procedure with a conditional?
I trying to rewrite a stored procedure and my SQL is not very good. What i'm hoping to do is write it so that if ModuleID is 555 then select a custom date range (eg. 2012-01-01 2012-12-31). The Current SP is below.
set ANSI_NULLS ON
set QUOTED_IDENTIFIER ON
GO
/*** EventsGetByRange ***/
ALTER PROCEDURE [dbo].[EventsGetByRange]
(
@Filter nvarchar(500),
@BeginDate datetime,
@EndDate datetime
)
AS
SET DATEFORMAT mdy
Declare @sql nvarchar(4000)
Select @sql = 'SELECT E.PortalID, E.EventID, E.RecurMasterID, E.ModuleID, E.EventDateBegin, E.EventDateEnd, '
+ 'E.EventTimeBegin, E.Duration, E.EventName, E.EventDesc, '
+ 'E.Importance, E.CreatedDate, '
+ 'CreatedBy = U.DisplayName, '
+ 'CreatorID = E.CreatedBy, '
+ 'E.Every, '
+ 'E.Period, '
+ 'E.RepeatType, '
+ 'E.Notify, '
+ 'E.approved, '
+ 'E.Signups, '
+ 'E.MaxEnrollment, '
+ '(Select count(*) from dbo.EventsSignups WHERE EventID = E.EventID and E.Signups = 1) as Enrolled, '
+ 'E.EnrollRoleID, '
+ 'E.EnrollFee, '
+ 'E.EnrollType, '
+ 'E.PayPalAccount, '
+ 'E.PayPalPassword, '
+ 'E.Cancelled, '
+ 'E.DetailPage, '
+ 'E.DetailNewWin, '
+ 'E.DetailURL, '
+ 'E.ImageURL, '
+ 'E.ImageType, '
+ 'E.ImageWidth, '
+ 'E.ImageHeight, '
+ 'E.ImageDisplay, '
+ 'E.Location, '
+ 'c.LocationName, '
+ 'c.MapURL, '
+ 'E.Category, '
+ 'b.CategoryName, '
+ 'b.Color, '
+ 'b.FontColor, '
+ 'E.Reminder, '
+ 'E.TimezoneOffset, '
+ 'E.SendReminder, '
+ 'E.ReminderTime, '
+ 'E.ReminderTimeMeasurement, '
+ 'E.ReminderFrom, '
+ 'E.SearchSubmitted, '
+ 'E.CustomField1, '
+ 'E.CustomField2, '
+ 'E.EnrollListView, '
+ 'E.DisplayEndDate, '
+ 'E.AllDayEvent, '
+ 'E.OwnerID, '
+ 'OwnerName = O.DisplayName, '
+ 'E.LastUpdatedAt, '
+ 'LastUpdatedBy = L.DisplayName, '
+ 'E.LastUpdatedID, '
+ '(Select ModuleTitle from dbo.Modules WHERE ModuleID = E.ModuleID) as ModuleTitle, '
+ 'RMOwnerID = r.OwnerID, '
+ 'r.RRULE, '
+ 'E.OriginalDateBegin, '
+ 'E.NewEventEmailSent '
+ 'FROM dbo.Events E '
+ 'inner join dbo.EventsRecurMaster AS r on E.RecurMasterID = r.RecurMasterID '
+ 'left outer join dbo.Users U on E.CreatedBy = U.UserID '
+ 'left outer join dbo.Users O on E.OwnerID = O.UserID '
+ 'left outer join dbo.Users L on E.LastUpdatedID = L.UserID '
+ 'left join dbo.EventsCategory b on E.Category = b.Category '
+ 'left join dbo.EventsLocation c on E.Location = c.Location '
+ 'WHERE (E.ModuleID = 555 AND E.EventTimeBegin BETWEEN 2012-01-01 AND 2012-12-31) OR ((E.EventTimeBegin <= DATEADD(DAY,1,''' + convert(varchar, @EndDate) + ''') AND DATEADD(minute,E.Duration,E.EventTimeBegin) >= ''' + convert(varchar, @BeginDate) + ''') OR '
+ ' (E.EventTimeBegin BETWEEN ''' + convert(varchar, @BeginDate) + ''' AND DATEADD(DAY,1,''' + convert(varchar, @EndDate) + ''')))'
+ ' AND E.Approved = 1'
+ ' AND E.Cancelled = 0'
+ ' ' + @Filter + ' '
+ ' ORDER BY E.EventDateBegin, E.EventTimeBegin, E.EventDateEnd'
EXEC (@sql)
UPDATE: I used the where statemnnt that Diego recommended but that is not having the desired result. It does not act as and If\Else scanrio (which makes sense when I think about it).
I need to first identify if the module ID is 555 and if so only pull the dates from in the hard coded range otherwise execute it as written. Please let me know if more detail is required.
A:
is the proc failing?
did you try adding E.ModuleID = 555 on the where clause?
Do you really want to hard code the value 555? how about passing it
on a parameter?
And most important question: why adding the sql statement to a
variable and execute it? why not just run the SQL? Is it because of
the @Filter variable?
also, sql server 2005 or 2008?
why nvarchar and not varchar on your variables ("n" occupies double
of space)
EDIT:
ok, you have a OR in there so it may be tricky. Do you want everything from code 555 despite the date range value, or everything within the date range and code 555?
I assume option 2 would make more sense so just add
E.ModuleID = 555
before the
+ ' AND E.Approved = 1'
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Development of an on-site, behavior-based safety audit for the residential construction industry.
The purpose of this study was to describe the development and implementation of an on-site, behavior-based safety audit based on a safety program designed specifically to reduce injuries and fatalities in the residential construction industry. The audit was used to assess safety hazards and safety compliance on residential construction work sites. Safety behaviors were scored as all-or-none. A high score was related to high safety compliance. A total of 195 audits were performed on residential construction companies from varying trades. Analysis of mean total scores indicated that companies that had received some form of safety training scored significantly higher than companies that had not received any (P<0.01). Analysis of mean total scores between company trades indicated that masonry/stucco application companies had significantly lower scores than most other trades represented (P<0.01). Challenges in designing, administering and analyzing the safety audits are discussed. | {
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Description
This book asks an important question often ignored by ancient historians and political scientists alike: Why did Athenian democracy work as well and for as long as it did? Josiah Ober seeks the answer by analyzing the sociology of Athenian politics and the nature of communication between elite and nonelite citizens. After a preliminary survey of the development of the Athenian "constitution," he focuses on the role of political and legal rhetoric. As jurymen and Assemblymen, the citizen masses of Athens retained important powers, and elite Athenian politicians and litigants needed to address these large bodies of ordinary citizens in terms understandable and acceptable to the audience. This book probes the social strategies behind the rhetorical tactics employed by elite speakers. A close reading of the speeches exposes both egalitarian and elitist elements in Athenian popular ideology. Ober demonstrates that the vocabulary of public speech constituted a democratic discourse that allowed the Athenians to resolve contradictions between the ideal of political equality and the reality of social inequality.
His radical reevaluation of leadership and political power in classical Athens restores key elements of the social and ideological context of the first western democracy.show more
Back cover copy
First, the book is meant to be a contribution to Greek history: an attempt to explain the social roots and internal functioning of the political system of an ancient city-state. I hope that many of those who consider the history and culture of fifth-and fourth-century Athens intrinsically interesting, as I do, will find this study valuable in formulating or reformulating their own assessments of classical Greece.show more | {
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My Life As A Spiritualist: A Former Psychic's Testimony
Supernatural phenomena interested me since childhood. A few psychic episodes as a child added to the intrigue I felt. My mother had also experienced psychic happenings since her childhood, but didn’t pursue it seriously until later. By the time I began Secondary School, she felt ready to experiment further. When walking her dogs in the park one day, a Medium approached, telling Mum he saw her potential as a Medium and invited her to a Spiritualist Church in Glasgow.
Very quickly, Mum became totally engrossed by the supernatural. As a new member of the Spiritualist Church, she attended Sunday services, mid week psychic development groups and Yoga classes. She shared everything she learned with me and I also became fascinated. Her heart’s desire was to train in Mediumship and the other Mediums encouraged this, asking her to join an Open Circle to learn to meditate and channel spirits of the deceased. Mum was keen to develop her abilities of Clairvoyance, Clairaudience and Clairsentience and to learn from other Mediums.
Every time Mum booked a Private Sitting for a Life Reading with a resident or visiting Medium, she would buy a tape of the session and we’d listen to it later that day. It amazed me that a half hour tape could contain so much communication from spirits. Minute details were relayed about our lives. Precise names, places and dates were often given. It was obvious the Mediums weren’t charlatans, falling upon names by sheer chance. They accurately described the physical appearance, personalities and even repeated common phrases of our dead relatives as they conversed with them.
When old enough to attend, I also joined the Spiritualist Church. We devoured mystical books on opening the chakras, Crystal Healing, Reincarnation, Alternative Therapies, etc. Attending New Age Centres and Psychic Fairs, we absorbed as much information as we could to help in our spiritual enlightenment. With our passion for environmental and conservation concerns, social justice and international peace, we gladly participated in healing people and animals, through either contact or distant psychic healing. Eventually, we also attended Transfiguration Sessions. Mum developed in the area of Automatic Writing and Mediums predicted I would become a Psychic Artist, drawing portraits of dead relatives and Spirit Guides for clients. I experimented with Kirlian Photography; using infra red film I captured images of ectoplasm as it formed.
Over the next ten years, we’d often hear of Mediums who could no longer control when spirits spoke to or through them. Many Mediums had nervous breakdowns, or attacked people claiming their Spirit Guides had forced them to, or were admitted to psychiatric wards. We heard reports of poltergeist activity in Medium’s homes. At first, we accepted explanations that mischievous or obnoxious spirits could sometimes come through and it was a potential hazard of the job. But when it happened to us, it became difficult to tolerate and almost impossible to function properly.
Our friends, the other Psychics and Mediums, failed to free our home from spirits. The spirits spoke to Mum constantly, depriving her of sleep, attacking her physically, chapping loudly from within wardrobes, slamming all the doors, etc.
On one of the occasions when they forced her into a trance against her will, she was frying food. When she came out of trance, the kitchen was consumed by fire. I arrived home after the Fire Brigade had extinguished it, just before it spread to other rooms. We all realised Mum, our dogs and cats could have been killed. One afternoon, Mum’s elderly Aunt who had also visited Spiritualist Churches, felt invisible hands grab her and throw her down our stairs. Her wrist was broken. Another day, while approaching shops, I watched in horror as Mum was lifted from the ground and catapulted from the pavement, landing on the bonnet of a passing car.
We decided to withdraw from Spiritualism and told our Spirit Guides to leave. To our shock, they laughed and insulted us. They began to physically attack us. This was perplexing as they had provided guidance and kindness for many years. It became obvious they’d deceived us, pretending to be benevolent, when in reality they were wicked all along.
The biggest shock however came when even our dead relatives turned against us. They also mocked and hit us. The spirits warned we couldn’t leave the occult, as we had unknowingly given them control from the first day we invited them into our lives.
During my second year at university, Mum’s health deteriorated and her Spirit Guides threatened to use her to kill people. Mum’s doctor couldn’t accept her accounts of poltergeist activity and diagnosed as Schizophrenic, she was detained in a Psychiatric Hospital. After months of heavy sedation, so they would discharge her, Mum deliberately told the psychiatrists she no longer heard voices. They did discharge her, but when she returned home, she endured further harassment from spirits and committed suicide.
A Christian I’d met in a Psychology Tutorial, invited me to her Pentecostal Church, explaining other Psychics who had experienced similar tragedies were set free from spiritual attacks when they accepted Jesus Christ as their Saviour. I renounced Spiritism and became a Christian. Later, a Pastor and her friend visited my mum’s home and successfully cleansed it the first time they prayed. At the Name of Jesus, all the spirits left and never returned. About a year later, I sold Mum’s home without worrying the new tenants would be harassed.
The Pentecostal Church did not portray dead religious traditions, instead it was lively, loving and fun. Members are trained by the Holy Spirit to prophecy about people’s future, bodies are healed and other miracles, signs and wonders occur. Actually, in a couple of years I saw more peopled healed in Pentecostal Churches than I ever saw in over ten years at Spiritualist Churches.
When I became a Christian, even before I had read the Biblical warnings of the occult in Deuteronomy chapter 18, I instinctively realised what had happened. The missing piece of the jigsaw fit into place. When our dead relatives and Spirit Guides began to attack Mum and I, it indicated they had deceived us, merely impersonating our loved ones. It made complete sense when Christians explained that it’s impossible for dead souls to return to talk with us, as they remain in heaven or hell for eternity. Also that, evil spirits are fallen angels, and they have existed for centuries possessing psychic knowledge of our families and historical figures down the generations. They can easily disguise their evil form to pose as our deceased family or any famous celebrity that ever lived. This was confirmed as I read in 2 Corinthians 11 to 14 : “And no wonder! For Satan himself masquerades as an angel of light. It is not surprising then, if his servants masquerade as servants of righteousness. Their end will be what their actions deserve.” The evil spirits working through Spiritualism, serve Satan in deceiving people into believing they are their dead relatives and Spirit Guides.
Before I left the occult, I was unaware the Bible advises in 1 John 4 verse 1 to 3 :
“Beloved, do not believe every spirit, but test the spirits, whether they are of God … every spirit that confesses that Jesus Christ has come in the flesh is of God, and every spirit that does not confess that Jesus has come in the flesh is not of God…And this is the spirit of the Antichrist…”
As a Spiritualist, I had believed Jesus was just a cosmic force; part of the universal consciousness, or a great Psychic Healer. Since my conversion I’ve met and read of many Psychics, Gypsies, Mediums, Witches and even Satanists who also discovered the entities of their Spirit Guides or dead relatives were not who they claimed to be. These people were also set free from demonic attack after receiving Christ into their lives. Two successful Glasgow Mediums, Sadie Bryce and Geordie Aitken also became Christians. Sadie went to the same Spiritualist Church I did. She spoke of her occult past in BBC programs and Geordie wrote a book detailing his. As Christians, Sadie and I wrote to each other and I met Geordie several times, discovering we all had been misled by spirits in the same ways.
Jesus healed me of fears, phobias and physical conditions. He has given me joy and peace I simply never knew existed. His very tangible Presence of pure love, is more real than any powerful encounter I experienced within Spiritualism.
After sharing my life story on TV and radio, I continue to hear of more people who are turning away from Spiritualist Meetings, Tarot Card Parties, etc. Recently, I completed a novella containing some detail of events Mum and I experienced within the occult. It also contains some wonderful encounters with Jesus and angels, very different from what I experienced in Spiritualism.
If you would like to order a copy of my book ‘A Spiritual Quest,’ please contact me on searching.08 At@ hotmail.co.uk
© 2009, Laura Maxwell, BA (Hons).
http://www.reachouttrust.org/articleView.php?id=352
http://www.facebook.com/inbox/?tid=1287388500477#/pages/Scotland-United-Kingdom/A-Spiritual-Quest/55259309502?ref=ts
http://www.youtube.com/user/LauraMaxwellExSpirit
The Truth about Psychics
Psychics, mediums, and ghosts have become a sensation in our culture today. As a result, there are many confusing and deceptive beliefs presented. Ron Rhodes, respected and popular biblical scholar, tackles the truth about ghosts and those who say they communicate with them and answers the questions:
Do ghosts in any shape or form exist? Why is there a rise in psychic phenomena today? What do psychics believe about God, Jesus, and salvation? What is Satan's role with the paranormal? How can parents protect their family from the psychic trend?
This reader–friendly presentation of intriguing facts and biblical insights will help Christians know how to respond to this fascination with the ultimate truth.
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Monday, June 9, 2008
There's A First Time For Everything
Daniel did a bunch of laundry yesterday, and he decided to include the dog bed covers we hadn't washed in three years. There's one particular bed that Gus and Charly both love. They take turns lying on it, and although they share the dog bed, I've never seen them actually lie down on it together, until last night.
Daniel stuffed the dog bed into its newly laundered cover, and the minute he set it down on the living room floor, both dogs threw themselves onto it, and didn't move for the next 2 quarters of the Celtics/Lakers basketball game. It seems even dogs prefer fresh clean bed sheets. Who knew... I mean, earlier this weekend they'd spent a half an hour rolling around in the dirt at the dog park.
Today I want to share with you these severely stylish dog beds you can buy at The Diva Dog. These beds are gorgeous to look at, but they're also stain, moisture, odor, and bacteria resistant. And you can even get the matching sofa pillows for yourself!
No comments:
About House & Hound
House & Hound was created by an interior designer who loves her dogs, and wants to share her dog inspired home decor ideas with you. I search for products that are modern, hip, and classy, so you can show off your dog love in style.
About Me
Product Reviews
Feel free to pitch a product and I'll get back to you if I'm interested in reviewing it. Product samples are welcome, but I do not accept paid product or editorial placements. Email [email protected] . | {
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Serum sclerostin levels are decreased in adult patients with different types of osteogenesis imperfecta.
There are no specific biochemical bone markers available for osteogenesis imperfecta (OI), and the role of sclerostin as a key regulator of bone formation in OI is unknown. We aimed to evaluate the role of sclerostin and its association with bone turnover markers as well as body composition parameters in adult patients with different types of OI. This was a case-control study in 27 adult patients and 50 healthy age- and gender-matched controls. Serum sclerostin levels and bone turnover markers including serum osteocalcin, amino terminal propeptide of type I procollagen, and CrossLaps as well as body composition parameters were determined in mild OI stage I (OI-I) and moderate-severe OI stages III-IV (OI-III-IV), according to Sillence classification. Data were compared with healthy controls. Sclerostin levels were significantly lower in OI-I (19.9 ± 10.9 pmol/L; P < .001) and OI-III-IV (13.3 ± 10.0 pmol/L; P < .001) compared with healthy adults (45.3 ± 14.9 pmol/L), even after adjustment for age, sex, bone mineral content, and body mass index. CrossLaps and PTH were significantly lower in OI-I (0.197 ± 0.15 ng/L; P = .007 and 33.7 ± 19.1 pg/L; P = .033, respectively) and OI-III-IV (0.221 ± 0.18 ng/L; P = .039, and 27.9 ± 14.7 pg/L; P = .001, respectively) than in healthy controls (0.322 ± 0.15 ng/L and 45.0 ± 16.6 pg/L). Amino-terminal propeptide of type I procollagen was below the reference range for OI-I and OI-III-IV. Patients with OI were shorter and lighter and had a decreased bone mineral content (P < .001) but similar fat distribution and lean body mass, compared with controls. Serum sclerostin levels were not related to any bone marker except osteocalcin, the number of prevalent fractures, or body composition readings. Decreased sclerostin levels in OI might reflect a down-regulation or negative feedback mechanism to prevent further bone loss. | {
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Saint-Pierre, Réunion
Saint-Pierre () is the third-largest commune in the French overseas department of Réunion. Located on the southwest side of the island, it is the capital of the French Southern and Antarctic Lands.
Climate
Infrastructure
Transportation
Pierrefonds Airport is located 5.5 kilometres outside of the commune. Opened in 1999, this is a small airport for commercial traffic. It has an IATA code of ZSE.
See also
Communes of the Réunion department
Twin towns-Sister cities
Saint-Pierre is twinned with:
Beau-Bassin Rose-Hill, Mauritius
References
INSEE
External links
Official website (in French)
Category:Communes of Réunion
Category:Subprefectures in France | {
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SUBROUTINE SLATRD( UPLO, N, NB, A, LDA, E, TAU, W, LDW )
*
* -- LAPACK auxiliary routine (version 3.0) --
* Univ. of Tennessee, Univ. of California Berkeley, NAG Ltd.,
* Courant Institute, Argonne National Lab, and Rice University
* October 31, 1992
*
* .. Scalar Arguments ..
CHARACTER UPLO
INTEGER LDA, LDW, N, NB
* ..
* .. Array Arguments ..
REAL A( LDA, * ), E( * ), TAU( * ), W( LDW, * )
* ..
*
* Purpose
* =======
*
* SLATRD reduces NB rows and columns of a real symmetric matrix A to
* symmetric tridiagonal form by an orthogonal similarity
* transformation Q' * A * Q, and returns the matrices V and W which are
* needed to apply the transformation to the unreduced part of A.
*
* If UPLO = 'U', SLATRD reduces the last NB rows and columns of a
* matrix, of which the upper triangle is supplied;
* if UPLO = 'L', SLATRD reduces the first NB rows and columns of a
* matrix, of which the lower triangle is supplied.
*
* This is an auxiliary routine called by SSYTRD.
*
* Arguments
* =========
*
* UPLO (input) CHARACTER
* Specifies whether the upper or lower triangular part of the
* symmetric matrix A is stored:
* = 'U': Upper triangular
* = 'L': Lower triangular
*
* N (input) INTEGER
* The order of the matrix A.
*
* NB (input) INTEGER
* The number of rows and columns to be reduced.
*
* A (input/output) REAL array, dimension (LDA,N)
* On entry, the symmetric matrix A. If UPLO = 'U', the leading
* n-by-n upper triangular part of A contains the upper
* triangular part of the matrix A, and the strictly lower
* triangular part of A is not referenced. If UPLO = 'L', the
* leading n-by-n lower triangular part of A contains the lower
* triangular part of the matrix A, and the strictly upper
* triangular part of A is not referenced.
* On exit:
* if UPLO = 'U', the last NB columns have been reduced to
* tridiagonal form, with the diagonal elements overwriting
* the diagonal elements of A; the elements above the diagonal
* with the array TAU, represent the orthogonal matrix Q as a
* product of elementary reflectors;
* if UPLO = 'L', the first NB columns have been reduced to
* tridiagonal form, with the diagonal elements overwriting
* the diagonal elements of A; the elements below the diagonal
* with the array TAU, represent the orthogonal matrix Q as a
* product of elementary reflectors.
* See Further Details.
*
* LDA (input) INTEGER
* The leading dimension of the array A. LDA >= (1,N).
*
* E (output) REAL array, dimension (N-1)
* If UPLO = 'U', E(n-nb:n-1) contains the superdiagonal
* elements of the last NB columns of the reduced matrix;
* if UPLO = 'L', E(1:nb) contains the subdiagonal elements of
* the first NB columns of the reduced matrix.
*
* TAU (output) REAL array, dimension (N-1)
* The scalar factors of the elementary reflectors, stored in
* TAU(n-nb:n-1) if UPLO = 'U', and in TAU(1:nb) if UPLO = 'L'.
* See Further Details.
*
* W (output) REAL array, dimension (LDW,NB)
* The n-by-nb matrix W required to update the unreduced part
* of A.
*
* LDW (input) INTEGER
* The leading dimension of the array W. LDW >= max(1,N).
*
* Further Details
* ===============
*
* If UPLO = 'U', the matrix Q is represented as a product of elementary
* reflectors
*
* Q = H(n) H(n-1) . . . H(n-nb+1).
*
* Each H(i) has the form
*
* H(i) = I - tau * v * v'
*
* where tau is a real scalar, and v is a real vector with
* v(i:n) = 0 and v(i-1) = 1; v(1:i-1) is stored on exit in A(1:i-1,i),
* and tau in TAU(i-1).
*
* If UPLO = 'L', the matrix Q is represented as a product of elementary
* reflectors
*
* Q = H(1) H(2) . . . H(nb).
*
* Each H(i) has the form
*
* H(i) = I - tau * v * v'
*
* where tau is a real scalar, and v is a real vector with
* v(1:i) = 0 and v(i+1) = 1; v(i+1:n) is stored on exit in A(i+1:n,i),
* and tau in TAU(i).
*
* The elements of the vectors v together form the n-by-nb matrix V
* which is needed, with W, to apply the transformation to the unreduced
* part of the matrix, using a symmetric rank-2k update of the form:
* A := A - V*W' - W*V'.
*
* The contents of A on exit are illustrated by the following examples
* with n = 5 and nb = 2:
*
* if UPLO = 'U': if UPLO = 'L':
*
* ( a a a v4 v5 ) ( d )
* ( a a v4 v5 ) ( 1 d )
* ( a 1 v5 ) ( v1 1 a )
* ( d 1 ) ( v1 v2 a a )
* ( d ) ( v1 v2 a a a )
*
* where d denotes a diagonal element of the reduced matrix, a denotes
* an element of the original matrix that is unchanged, and vi denotes
* an element of the vector defining H(i).
*
* =====================================================================
*
* .. Parameters ..
REAL ZERO, ONE, HALF
PARAMETER ( ZERO = 0.0E+0, ONE = 1.0E+0, HALF = 0.5E+0 )
* ..
* .. Local Scalars ..
INTEGER I, IW
REAL ALPHA
* ..
* .. External Subroutines ..
EXTERNAL SAXPY, SGEMV, SLARFG, SSCAL, SSYMV
* ..
* .. External Functions ..
LOGICAL LSAME
REAL SDOT
EXTERNAL LSAME, SDOT
* ..
* .. Intrinsic Functions ..
INTRINSIC MIN
* ..
* .. Executable Statements ..
*
* Quick return if possible
*
IF( N.LE.0 )
$ RETURN
*
IF( LSAME( UPLO, 'U' ) ) THEN
*
* Reduce last NB columns of upper triangle
*
DO 10 I = N, N - NB + 1, -1
IW = I - N + NB
IF( I.LT.N ) THEN
*
* Update A(1:i,i)
*
CALL SGEMV( 'No transpose', I, N-I, -ONE, A( 1, I+1 ),
$ LDA, W( I, IW+1 ), LDW, ONE, A( 1, I ), 1 )
CALL SGEMV( 'No transpose', I, N-I, -ONE, W( 1, IW+1 ),
$ LDW, A( I, I+1 ), LDA, ONE, A( 1, I ), 1 )
END IF
IF( I.GT.1 ) THEN
*
* Generate elementary reflector H(i) to annihilate
* A(1:i-2,i)
*
CALL SLARFG( I-1, A( I-1, I ), A( 1, I ), 1, TAU( I-1 ) )
E( I-1 ) = A( I-1, I )
A( I-1, I ) = ONE
*
* Compute W(1:i-1,i)
*
CALL SSYMV( 'Upper', I-1, ONE, A, LDA, A( 1, I ), 1,
$ ZERO, W( 1, IW ), 1 )
IF( I.LT.N ) THEN
CALL SGEMV( 'Transpose', I-1, N-I, ONE, W( 1, IW+1 ),
$ LDW, A( 1, I ), 1, ZERO, W( I+1, IW ), 1 )
CALL SGEMV( 'No transpose', I-1, N-I, -ONE,
$ A( 1, I+1 ), LDA, W( I+1, IW ), 1, ONE,
$ W( 1, IW ), 1 )
CALL SGEMV( 'Transpose', I-1, N-I, ONE, A( 1, I+1 ),
$ LDA, A( 1, I ), 1, ZERO, W( I+1, IW ), 1 )
CALL SGEMV( 'No transpose', I-1, N-I, -ONE,
$ W( 1, IW+1 ), LDW, W( I+1, IW ), 1, ONE,
$ W( 1, IW ), 1 )
END IF
CALL SSCAL( I-1, TAU( I-1 ), W( 1, IW ), 1 )
ALPHA = -HALF*TAU( I-1 )*SDOT( I-1, W( 1, IW ), 1,
$ A( 1, I ), 1 )
CALL SAXPY( I-1, ALPHA, A( 1, I ), 1, W( 1, IW ), 1 )
END IF
*
10 CONTINUE
ELSE
*
* Reduce first NB columns of lower triangle
*
DO 20 I = 1, NB
*
* Update A(i:n,i)
*
CALL SGEMV( 'No transpose', N-I+1, I-1, -ONE, A( I, 1 ),
$ LDA, W( I, 1 ), LDW, ONE, A( I, I ), 1 )
CALL SGEMV( 'No transpose', N-I+1, I-1, -ONE, W( I, 1 ),
$ LDW, A( I, 1 ), LDA, ONE, A( I, I ), 1 )
IF( I.LT.N ) THEN
*
* Generate elementary reflector H(i) to annihilate
* A(i+2:n,i)
*
CALL SLARFG( N-I, A( I+1, I ), A( MIN( I+2, N ), I ), 1,
$ TAU( I ) )
E( I ) = A( I+1, I )
A( I+1, I ) = ONE
*
* Compute W(i+1:n,i)
*
CALL SSYMV( 'Lower', N-I, ONE, A( I+1, I+1 ), LDA,
$ A( I+1, I ), 1, ZERO, W( I+1, I ), 1 )
CALL SGEMV( 'Transpose', N-I, I-1, ONE, W( I+1, 1 ), LDW,
$ A( I+1, I ), 1, ZERO, W( 1, I ), 1 )
CALL SGEMV( 'No transpose', N-I, I-1, -ONE, A( I+1, 1 ),
$ LDA, W( 1, I ), 1, ONE, W( I+1, I ), 1 )
CALL SGEMV( 'Transpose', N-I, I-1, ONE, A( I+1, 1 ), LDA,
$ A( I+1, I ), 1, ZERO, W( 1, I ), 1 )
CALL SGEMV( 'No transpose', N-I, I-1, -ONE, W( I+1, 1 ),
$ LDW, W( 1, I ), 1, ONE, W( I+1, I ), 1 )
CALL SSCAL( N-I, TAU( I ), W( I+1, I ), 1 )
ALPHA = -HALF*TAU( I )*SDOT( N-I, W( I+1, I ), 1,
$ A( I+1, I ), 1 )
CALL SAXPY( N-I, ALPHA, A( I+1, I ), 1, W( I+1, I ), 1 )
END IF
*
20 CONTINUE
END IF
*
RETURN
*
* End of SLATRD
*
END
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Q:
Motivic integration in positive characteristic: how much is known?
It seems that in papers on motivic integration people usually assume the base field to have characteristic $0$ (and algebraically closed?). My question is: how much can one prove over a positive characteristic field? What are the main difficulties in this setting; can one prove certain weaker versions of the main results of the theory (for example, using alterations instead of Hironaka's resolution of singularities)? Is there any text that treats these questions systematically?
A:
There are many theories of motivic integration. The first one, due to Kontsevich (on smooth varieties) and developed by Denef-Loeser (in general, Inventiones Math., 1999) assumed originally that the characteristic was zero. Replacing arc schemes by Greenberg schemes, it has been generalized by Looijenga (Bourbaki seminar, Astérisque 276, 2002) to encompass varieties over $k[[t]]$, and then by Sebag (Bulletin SMF, 2004) to allow formal schemes over an arbitrary complete discrete valuation ring. A nice application is the definition by Loeser-Sebag (Duke Math. J., 2003) of the motivic Serre invariant of a rigid analytic space.
This geometric theory is presented in this generality in a book in preparation by Nicaise, Sebag and myself.
More recently, Cluckers and Loeser developed a more general theory (Inventiones Math., 2008 and Annals of Math., 2010) over henselian discretely valued fields of residual characteristic zero (rings such as $k[[t]]$, where the characteristic of $k$ is zero). The theory of Hrushovski and Kazhdan has a similar limitation.
Cluckers and Loeser have then extended their theory to arbitrary henselian discretely valued fields of characteristic zero (Crelle, 2013).
While algebraic geometry works well in arbitrary characteristic, model theoretic inputs (e.g., Pas's theorem) presently impose such restrictions on the characteristic.
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Q:
Android ListView Get row on button click
I have a custom adapter class for a listview and I want to be able to access the content of a specific row by clicking a button on it. I tried to create a ViewHolder, but I get a NPE error when I try to click it.
static class ViewHolder {
TextView camera;
TextView players;
TextView max_players;
ImageView privata;
Button Buton;
}
@Override
public View getView(int position, View convertView, ViewGroup parent) {
String variabile[] = getItem(position).split("\\s+");
LayoutInflater linflater = LayoutInflater.from(getContext());
View customView = linflater.inflate(R.layout.custom_row, parent, false);
final ViewHolder holder = new ViewHolder();
holder.camera = (TextView) customView.findViewById(R.id.Nume);
holder.players = (TextView) customView.findViewById(R.id.players);
holder.max_players = (TextView) customView.findViewById(R.id.max_players);
holder.privata = (ImageView) customView.findViewById(R.id.privata);
holder.Buton = (Button) customView.findViewById(R.id.Buton);
holder.camera.setText(variabile[0]);
if (!variabile[1].equals("true")) {
parola = false;
holder.privata.setVisibility(View.INVISIBLE);
}
holder.players.setText(variabile[2]);
holder.max_players.setText(variabile[3]);
room_id = variabile[4];
nume = variabile[5];
holder.Buton.setOnClickListener(new View.OnClickListener() {
public void onClick(View v) {
hash = new HashMap<String, String>();
hash.put("name", nume);
hash.put("room", room_id);
if (intra) {
holder.Buton.setText("Iesi");
site = siteul + "/join";
intra = false;
} else {
holder.Buton.setText("Intra");
site = siteul + "/leave";
intra = true;
}
new ATask().execute(site);
}
});
return customView;
}
A:
When using the ViewHolder pattern, you should check if the convertView in null or has been created before, in the getView method, and after that use setTag and getTag methods. like this :
if (convertView == null)
{
LayoutInflater linflater = LayoutInflater.from(getContext());
convertView = linflater.inflate(R.layout.your_list_item_view, parent, false);
viewHolder.textView = (TextView)convertView.findViewById([the id]);
.
.
.
convertView.setTag(holder);
}
else
{
holder = (ViewHolder) convertView.getTag();
}
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Tuesday, September 8, 2009
Familiar Road
I woke up in my tent around one am, and since I've learned that I just don't sleep very soundly in the tent, I just listened to the sounds, and stared up at the stars for a while, hoping to see a meteorite or two. At one point, I could feel something, a weird sensation around the back of my neck, and then a crawling sensation, as if something were crawling in my neck. I reached my hand around and felt something insect-like, pulled it away, but then started to get that weird feeling you get when a bunch of bees sting you, sort of a head rush. Hard to describe. Then, a definite, sharp pain right at the nape of my neck. I feel the spot again, and already there's a big knot of swelling forming. I'm thinking "what? Are there tarantulas in Wyoming?" I had my screen door totally zipped shut too. Then I rolled over and-- woke up. The whole insect biting thing had been a dream, and confirmation that I did in fact fall asleep sometime between two-thirty and three-thirty. Relief.
I dozed until my alarms started going off (two each in my watch and cell phone). Quietly got up and walked to the showers. I hadn't noticed this before, but the men's showers at the Chuckwagon RV Campground have quite an art collection. There are five versions of the famous "Dogs Playing Poker" series, shellacked to pieces of tree bark. I have always liked those pictures. Maybe because I was very young when I first noticed them. I wonder what art the women get?
I still had about an hour of darkness, so I boiled water for coffee as I took down the tent and started packing the trailer. I knew this was the last time I'd be cooking, so I just let the stove go for a long time, burning off those pounds of white gas.
And now for a short commercial break: Did I mention that I have been drinking coffee from my very own Revolution Mugs coffee cup? If you haven't ordered yours, better get going. This mug has traveled hundreds of miles with me now. A much more satisfying weight to drag over mountain passes than the one-pound box of tasteless linguini, or the 6 heavy packs of albacore tuna and chicken breast.
Now back to our story.
Today was super humid, and this morning would be my first IFR departure of the trip. A heavy but shallow ground fog had formed, just at sunrise, and as I headed east on highway 26, the sun was a huge white disk you could stare at just as easily as the moon. The road shoulders were smooth, the highway was flat, and the miles just melted by. As always, rural drivers almost always move over half a lane to pass, even if I'm six feet away in an eight foot shoulder. I've even seen oncoming cars drive on the far side rumble strip, as if I'm radioactive or something. This would be amazing behavior in the Puget Sound basin.
Highway 26 is arrow-straight as it leads past these last few towns into Scottsbluff. Fortunately, the towns are spaced six to eight miles apart, so the entertainment value is a little higher. I had planned to have a real breakfast in Lingle, but the diner there apparently closed its doors (I was told this by a woman working at the gas station, where I picked up a maple-bar-ish twisty something pastry to tide me over) last summer. Next town: Torrington, Wyoming, where I found the 77 Grill at a big truck stop. Apparently the only place open, because it was hopping. I got my fill and continued down the road. Torrington is also the town closest to the farm of my Grandparents on my Mom's side. It's all dirt roads to get out there, and no one left who would know me, so I don't think I'll be riding out that way this time.
The sequence of little towns down this road is a very familiar and nostalgic path for me, as I have counted my way down these last miles many times from the back seat of my parent's car as we traveled each summer to Scottsbluff. I remember sometimes we competed to see who could be the first across the state line. The best way to do this was to be crafty and pretend you weren't really thinking about it, and just happen to be in the front seat when that border was approaching. That way you could just make sure one of your feet was farther forward than the driver's right foot. But, you had to be careful, there might be a last-second lunge over the seat backs, and a pair of hands attempting to reach up under the dashboard.
I reached the Nebraska border at ten am, and almost immediately, the town of Henry, with the fading, hand painted sign "Welcome to Henry, Scottsbluff County, Home to a Undergound Environmental Hazard." Then Morrill, Mitchell, and now I was finally in visual contact with the bluff itself, the national monument which shares its name with the town and county.
So humid today, the air feels thick and hard to breathe, plus in the last few miles, of course I pick up a little headwind. Still it's exciting to arrive in this fashion, and I can hardly believe I'm finally here. One more Twilight Zone (Outer Limits?) moment just after Mitchell, where the grasshoppers which heretofore had been hopping out of my way as I ride, are suddenly jumping right at me, and onto me from all sides. Reminded me of that episode where the couple is marooned in the desert overnight, and have to deal with attacks from sage brush, and then frogs.
As I ride along highway 26, I pass by Sunset Memorial, the cemetery where all my grandparents, and an uncle are buried. I stop and think about taking a break to go look at the markers, but after watching the traffic (65 speed limit, divided highway), I decide that a visit isn't worth the risk of joining them prematurely and permanently. I imagine my grandad Dale understanding my decision as I ride away. A couple of passing cars give a toot and hold out a peace sign, not sure what that's about. Finally, a right turn off the highway onto fifth avenue, past the Appleby's where a few fun family evenings were spent after my grandmother's funeral a few years back. A left turn, and... oops, streets are counting opposite the way I anticipated, I'm on sixth, u-turn, back the other way, there's the old Terry mansion, and another landmark, old Ford pickup, and I'm here!
Thinking: Shower. Glass of wine. Pizza. Sitting. (Made me think of Borat. "Look at me, I am sitting on a chair.") Send a text to Theo. Oh, and finally I can make a quick run to the grocery store for shaving implements. I look like Gabby Whiskers. No wonder people are afraid of me when I roll into town.
8 comments:
Congratulations, Kevin. What a feat!It never occurred to me before why they called it Scotts Bluff. It looks beautiful, in a Nebraska sort of way. When will you be home? Chris has been bugging me to have beer. We wait to drink you.
Lu and I have enjoyed the hell out of reading your adventures - especially a big catch up the other day after getting back from our own (infinitely cushier) trip to Alaska. Lu has enjoyed listening to them - she got the audiobook version from me. So thanks for the privilege of tagging along on your strange Western odyssey. You had us on the edges of our tenterhooks a few times there, pal - but I have to say that this latest entry tops them all, with is recurrent David Lynch vibe. Nice mugs, yours & yours - gabby whiskers! On to the final post.
About Me
I'll be using this blog to update my progress as I ride from Seattle, Washington to Scottsbluff, Nebraska. I'll be using a netbook to post new information, and I'll be hoping I can find islands of wifi often enough along the way to make this a worthwhile way for others to see where I am. | {
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Removals New York
Arriving in a new country as part of an international relocation can be very emotional and overwhelming, particularly if your removal is as far afield as New York. With so much to think about and so many new experiences in a short space of time, it could be a good idea to engage the services of a New York removals expert to help you on arrival, and not just in the run-up to the move.
Your New York removals expert might be able to help you with things like:
Collection from the airport
This would remove the need for you and your family to worry about how you’ll find your new home or temporary accommodation on your first day, especially when you’re tired from a long flight.
A welcome pack
A good New York removals expert will put together a welcome pack at your accommodation, aimed at helping you to acclimatise. For example, it could include information like phone numbers for local services, customs information, maps of the local area and more.
Furnishing your home
If your belongings are still in transit from the UK, your New York removals consultant may be able to arrange for your new home or temporary accommodation to be furnished according to your needs. They could also arrange for utilities like water and power to be connected, and set up a mobile phone for you.
Want to find a New York removals company?
At Premier Relocation, we’re expert New York movers and relocation professionals. We can carry out all of these services and more, so contact us today to see how we can help you.
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The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this. | {
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Jason Babin moves south, Eagles' teammates move on (With Video)
PHILADELPHIA -- The call came while Trent Cole was enjoying what was left of his Tuesday offday, spent with teammate, buddy and hunting partner Jason Babin.
They were in the garage when Babin said the Eagles cut him. Had to be a joke. Not even a good one.
"I thought he was playing around," Cole said. "I really thought he was just playing around. But then he said it's for real.
"I didn't know what to say to him. I didn't have no words. It's a life-changing thing."
The release of Babin, who led the Eagles with 18 sacks last season and again with 5½ this campaign, took all of his linemates by surprise.
They texted it out in the group chat room they set up for the defensive linemen. They liked various statuses on Facebook.
Babin's teammates correctly predicted he would quickly get a job. The Jacksonville Jaguars scooped the pass rusher off waivers Wednesday. Who would have thought Babin would end up with a worse team than the Eagles (3-8)?
"Babin was one of those guys I went and talked to besides Cullen Jenkins and Trent," rookie tackle Fletcher Cox said. "If I had a question about something on the field I asked him. I was sure he'd know."
Cox paused.
"Nobody had any idea this was going to happen," he said.
Eagles head coach Andy Reid said Babin was released so that younger defensive ends could be evaluated.
Brandon Graham moved right into Babin's starting slot at left end. Phillip Hunt and rookie Vinny Curry also figure to get chunks of game time when the Eagles take on the Dallas Cowboys Sunday night at Cowboys Stadium.
Then again, it's not like the Eagles needed the roster space. They practiced Wednesday with only 51 players on their roster. Several were limited or unable to practice, the latter of which included quarterback Michael Vick and running back LeSean McCoy, both coming off concussions.
The reality is the Eagles aren't going to the playoffs for the second straight season. They've lost seven straight games. And they apparently don't want to pay any more than they have to if this is the way it's going to be. They saved $1.69 million by getting rid of Babin, now being paid by the Jaguars.
"When you lose, stuff like this happens," veteran wide receiver Jason Avant said. "It's one of those things. So the best thing that we can take from this is just win. Try to get some wins.
"There is a message that everybody has to play better."
For Graham, it's another chance to play like a first-round draft choice. And probably his last chance with the Eagles.
"It lets me know I better make sure I stay on my game all through my career," Graham said. "Don't never take nothing for granted. I could be gone tomorrow, even though I think now is my shot. They must just say 'Graham is gone, too.' You never know. I'm just going to take advantage and go hard in practice today and take it one day at a time." | {
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Telomeres protect the natural ends of linear chromosomes from recognition by the DNA damage response machinery. Not surprisingly, critically short or improperly 'capped' telomeres are major sources of genomic instability and have been linked to premature aging, hematological malignancies, and solid tumor formation. Thus, investigating how telomeres are maintained and how aberrant telomeres signal a DNA damage response, is essential to our understanding of cellular transformation. The objective of this proposal is to further define the mechanisms regulating the DNA damage response at telomeres and define how defects in this process promote genomic instability and ultimately, cancer progression. The studies described here will undoubtedly further our knowledge of the mechanisms involved in cancer progression and will lay the foundation for advances in disease diagnosis and/or treatment. The specific aims are outlined below. Specific Aim 1 will use a combination of biochemistry and cell biology to understand how the human POT1 protein protects telomere through two distinct functions. In mice, POT1 diverged into two genes encoding mPOT1a and mPOT1b proteins each possessing a unique function in telomere end protection. In this aim, I will use mouse mPOT1a and mPOT1b to determine how these two proteins differ in their ability to specifically repress ATR and how the single POT1 protein in humans accomplishes this function. Teasing out the functional domains in human POT1 will allow us to better understand how POT1 functions at telomeres and how mutations in POT1 may impair telomere end protection and contribute to tumorigenesis. Specific Aim 2 will use a combination of biochemistry and cell biology to determine how TRF2 represses ATM at telomeres. The goal of this aim is to understand mechanistically how TRF2 functions to inhibit ATM activation and ultimately, preserve genomic stability. Using new in vivo and in vitro assays, I will test the hypothesis TRF2 inhibits ATM activation by antagonizing binding of the DNA damage sensors at telomeric DNA. TRF2 is a key factor in telomere length maintenance and signaling, thus, dissecting the role of TRF2 in ATM inhibition will not only advance our current knowledge of how normal telomeres are maintained, but also how dysfunctional telomeres evoke a DNA damage response. The studies I have proposed here may shed light on how the telomere checkpoint is evoked and subsequently bypassed in cancers. Specific Aim 3 will use cell biology to investigate the role of the non-coding RNA TERRA in regulation of the DNA damage response at telomeres. TERRA is critical for maintaining genomic stability and is downregulated in a subset of human cancers suggesting that defects in TERRA contribute to telomere dysfunction and eventually, cellular transformation. The goal of this aim is to identify factors responsible for regulating the transcription, degradation, and/or localization of TERRA and to dissect the function of TERRA in maintaining genome stability. Despite my recent training in biochemistry, I will need 1-2 additional years of training to establish myself specifically as a telomere biochemist. This is a niche that is underrepresented in the field of telomere biology, and with additional training I feel I can make substantial contributions to the field. As an independent investigator, I will adapt my research from global DNA damage and genome maintenance, to telomere homeostasis and genome maintenance. In addition, I will continue to pursue research in the field of cancer biology and will begin to address the questions outlined in this proposal. Further defining the mechanism(s) regulating telomere stability will inevitably lead to a better understanding of cellular transformation and ma ultimately provide much needed therapeutic insight. I am eager to dissect the mechanisms regulating telomere homeostasis and would greatly appreciate the opportunity to conduct this research with the support of a K99 award. Receipt of this award would not only allow me to expand my research plan, but also establish myself as a primary investigator in the field of cancer biology. PUBLIC HEALTH RELEVANCE: Telomeres protect the natural ends of linear chromosomes from being recognized as sites of DNA damage. Given that DNA damage is a major source of genomic instability, the objective of this proposal is to further dissect the mechanisms regulating telomere maintenance and how defects in this process promote the genomic instability associated with cancer development. | {
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[A case of Mycobacterium fortuitum pulmonary disease in a healthy young woman successfully treated with ciprofloxacin and doxycycline].
A 22 year-old woman was admitted to our hospital complaining of subtle fever and productive cough. She did not smoke and had no underlying disease. Her chest radiograph showed infiltration in the right upper lung field. A diagnosis of Mycobacterium fortuitum pulmonary disease was made on the basis of isolation of M. fortuitum from repeated sputum cultures. On admission, we administered standard antimycobacterial agents, but found the M. fortuitum isolated in this case to be completely resistant to them. We then administered antibiotics including 600 mg of ciprofloxacin and 200 mg of doxycycline. The pneumonic findings on chest X-ray and her clinical symptoms gradually improved thereafter. The in vitro susceptibility tests confirmed the efficacy of ciprofloxacin and doxycycline. We concluded that these drugs contributed significantly to improve the disease. | {
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Q:
How can I use datepicker for filter in p:dateTable?
i am new in jsf with primeFaces.I am trying to filter DateTable with datepicker.I made DateTable filter when i select the date from datepicket filter works, but When I delete text from the field, the filter is still active.How can i fix that this is my code from xhtml.
<p:column headerText="Date" filterBy="#{example.date}" sortBy="#{example.date}" filterMatchMode="contains">
<f:facet name="filter">
<p:calendar pattern="dd/MM/yyyy">
<p:ajax event="dateSelect" oncomplete="PF('table').filter()"/>
</p:calendar>
</f:facet>
<h:outputText value="#{example.date}">
</h:outputText>
How can i handle event on filter text input change?
A:
I slove problem adding event "onblur". This is my code now
<f:facet name="filter">
<p:calendar pattern="dd/MM/yyyy" onblur="PF('table').filter()">
<p:ajax event="dateSelect" oncomplete="PF('table').filter()" />
</p:calendar>
</f:facet>
| {
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/*
* start.S : RTEMS entry point
*
* Copyright (C) 1999 Eric Valette. [email protected]
*
* The license and distribution terms for this file may be
* found in the file LICENSE in this distribution or at
* http://www.rtems.org/license/LICENSE.
*
* Modified for mvme3100 by T. Straumann, 2007.
*
*/
#include <rtems/asm.h>
#include <libcpu/powerpc-utility.h>
#include <bspopts.h>
#define SYNC \
sync; \
isync
#define KERNELBASE 0x0
/* cannot include <bsp.h> from assembly :-( */
#ifndef BSP_8540_CCSR_BASE
#define BSP_8540_CCSR_BASE 0xe1000000
#endif
#define ERR_DISABLE_REG (BSP_8540_CCSR_BASE + 0x2e44)
.text
.globl __rtems_entry_point
.type __rtems_entry_point,@function
__rtems_entry_point:
mr r31,r3
mr r30,r4
mr r29,r5
mr r28,r6
mr r27,r7
/* disable checking for memory-select errors; motload has all TLBs
* mapping a possible larger area as memory (not-guarded, caching-enabled)
* than actual physical memory is available.
* In case of speculative loads this may cause 'memory-select' errors
* which seem to raise 'core_fault_in' (found no description in
* the manual but I experienced this problem).
* Such errors (if HID1[RFXE] is clear) may *stall* execution
* leading to mysterious 'hangs'.
* Note: enabling HID1[RFXE] at this point makes no sense since
* exceptions are not configured yet. Therefore we disable
* memory-select errors.
* Eventually (bspstart.c) we want to delete TLB entries for
* which no physical memory is present.
*/
lis r3, ERR_DISABLE_REG@ha
lwz r4, ERR_DISABLE_REG@l(r3)
/* disable memory-select errors */
ori r4, r4, 1
stw r4, ERR_DISABLE_REG@l(r3)
/* Use MotLoad's TLB setup for now; caches are on already */
bl __eabi /* setup EABI and SYSV environment */
bl zero_bss
/*
* restore original args
*/
mr r3,r31
mr r4,r30
mr r5,r29
mr r6,r28
mr r7,r27
bl save_boot_params
/*
* Initialize start stack. The stacks are statically allocated and
* properly aligned.
*/
LA r1, _ISR_Stack_area_end
subi r1, r1, PPC_DEFAULT_CACHE_LINE_SIZE
li r0, 0
stw r0, 0(r1)
/*
* We are now in a environment that is totally independent from
* bootloader setup.
*/
/* pass result of 'save_boot_params' to 'boot_card' in R3 */
bl boot_card
/* point of no return: reset board here ? */
| {
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Hi bubs.
Plump Tokens
PLUMP TOKENS
$1 = 10 plump tokens (PT)
Your name at the end of comics for one month (default at $3+ tiers) - 30 PT
Rustled Jimmies wallpaper pack (one desktop, one mobile) - 30 PT
Patreon supporter instagram story shoutout - 50 PT
Rustled Jimmies vinyl sticker pack (4) - 140 PT
Quick digital portrait - 150 PT black and white, 200 PT color
Original physical sketch - 250 PT
You drawn as a RJ character in a comic - 500 PT
More rewards coming soon.
FAQ
Q: How do I know how many plump tokens I have?
A: You can calculate your token amount by multiplying the current tier you’re subscribed to x the number of months you’ve been subscribed. Remember that $1 = 10 plump tokens each month. Or, you can always just ask me in the Discord server’s #shop section.
Q: When will my plump tokens be added to my account?
A: Plump tokens are added on the 1st of every month.
Q: What if I want more plump tokens than the current tiers allow?
A: You can always make a custom pledge. $1 = 10 monthly plump tokens.
Q: I don’t use Discord?
A: That’s fine! You can still redeem your plump tokens by sending me a message here on Patreon too.
Q: Does "All previous rewards" mean I get my tier's tokens + the other tier's?
A: No. Plump Tokens are not included under "All previous rewards".
**NOTE: All token redemptions must happen before the 7th of each month**
Your name at the end of comics for one month (default at $3+ tiers) -Rustled Jimmies wallpaper pack (one desktop, one mobile) -Patreon supporter instagram story shoutout -Rustled Jimmies vinyl sticker pack (4) -Quick digital portrait -black and white,colorOriginal physical sketch -You drawn as a RJ character in a comic -More rewards coming soon.A: You can calculate your token amount by multiplying the current tier you’re subscribed to x the number of months you’ve been subscribed. Remember that $1 = 10 plump tokens each month. Or, you can always just ask me in the Discord server’s #shop section.A: Plump tokens are added on the 1st of every month.A: You can always make a custom pledge. $1 = 10 monthly plump tokens.A: That’s fine! You can still redeem your plump tokens by sending me a message here on Patreon too.A: No. Plump Tokens are not included under "All previous rewards".
Thanks for stopping by my Patreon page! My name's Sam and I make Rustled Jimmies - comics and cartoons about anything from sharks buying groceries, to flesh people sticking their hands in possums. I also enjoy long walks on the beach in full platemail armor, reading poetry under the moonlight, and sprinting through fields of dandelions screaming profanities. But that's enough about me.Right now I'm making Rustled Jimmies in my free time, but hopefully someday I can focus all of my time towards it. Patreon is the #1 way to support my cartoons, and by becoming a patron you automatically become one of my favorite people. Plus, there's a lot of really cool rewards that you can unlock with yourGOOD QUESTION - Plump tokens are given to you at the beginning of every month depending on what tier you select. You can then use your plump tokens to redeem rewards in the shop down below! Take a look around and let me know in the Discord server'schannel if there's anything you'd want to buy. Remember, no shoes, no shirt, extra service.<3 Sam | {
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[terrain_type]
ident = flamefood_tree_snow
name = "Flamefood Tree (Snow)"
character = a
color = 128.128.32
base_terrain_type = snow
overlay = true
flag = land
flag = forest
flag = unpassable
graphics = "terrain/flamefood_tree_snow.png"
resource = lumber
solid_tile = 18
destroyed_tile = 16
[transition_tile]
transition_type = north
tile = 2
[/transition_tile]
[transition_tile]
transition_type = south
tile = 34
[/transition_tile]
[transition_tile]
transition_type = west
tile = 17
[/transition_tile]
[transition_tile]
transition_type = east
tile = 19
[/transition_tile]
[transition_tile]
transition_type = northwest_outer
tile = 1
[/transition_tile]
[transition_tile]
transition_type = northeast_outer
tile = 3
[/transition_tile]
[transition_tile]
transition_type = southwest_outer
tile = 33
[/transition_tile]
[transition_tile]
transition_type = southeast_outer
tile = 35
[/transition_tile]
[transition_tile]
transition_type = northwest_inner
tile = 10
[/transition_tile]
[transition_tile]
transition_type = northeast_inner
tile = 11
[/transition_tile]
[transition_tile]
transition_type = southwest_inner
tile = 26
[/transition_tile]
[transition_tile]
transition_type = southeast_inner
tile = 27
[/transition_tile]
[transition_tile]
transition_type = northwest_southeast_inner
tile = 30
[/transition_tile]
[transition_tile]
transition_type = northeast_southwest_inner
tile = 14
[/transition_tile]
[/terrain_type]
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The video is 17 minutes long; the first 6 minutes is a long drive during which you don’t see a whole lot of intact buildings…and many stretches with no buildings at all. See also a 1905 streetcar trip down Market Street. (via devour) | {
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Shirley Smith (politician)
Shirley A. Smith (born November 29, 1950) is a former state senator for the 21st District of the Ohio Senate. Previously, she was a member of the Ohio House of Representatives. She is a Democrat.
Life and career
Smith has worked in sales and marketing, and as a radio talk-show host for a major radio station in Cleveland, and has also served as an independent consultant for Coca-Cola Bottling Company.
When incumbent C. J. Prentiss decided to run for the Ohio Senate, Smith and four other Democrats sought to replace her in the 1998 primary election. Smith won the District 8 nomination with 35.29% of the vote. She won the general election against Republican Dominic Rini with 86.15% of the vote. Smith won reelection in District 8 in 2000 against Republican Ronnie Jones with 87.2% of the vote.
In 2002, Smith again faced a primary challenge from four other Democrats, due to redistricting. However she won the District 10 nomination with 43.66% of the vote. She went unopposed in the general election and was unopposed for the 2004 general election. For the 126th General Assembly, Smith served as secretary of the Ohio Legislative Black Caucus (OLBC).
Ohio Senate
In late 2005, Smith announced that she would run to succeed term-limited Prentiss in the Senate, along with Representatives Annie L. Key, Claudette Woodard and two other Democrats. While it was a contested primary, Smith defeated the opposition to take the District 21 nomination with 50.86% of the votes. She won the general election with 85.34% of the electorate. In the 127th General Assembly, Smith served as president of the OLBC.
Early in 2008, the Senate Democrats ousted Minority Leader Teresa Fedor and replaced her with Ray Miller, as well as Smith as assistant minority leader. With the beginning of the 128th General Assembly, the caucus retained Smith in her role as assistant minority leader under Capri Cafaro.
In 2010, Smith won election to a second term in the Senate, defeating Republican Burrell Jackson with 84.4% of the vote.
Smith resigned a month prior to the end of her term.
Electoral history
Personal life
Smith is divorced with two children. She lives in Cleveland, but also owns property in South Euclid, Ohio.
References
External links
The Ohio Ladies' Gallery: Shirley Smith
Project Vote Smart - Senator Shirley Smith (OH) profile
Follow the Money - Shirley Smith
20102006 2004 2002 2000 1998 campaign contributions
Category:1950 births
Category:Living people
Category:African-American women in politics
Category:Cleveland State University alumni
Category:John F. Kennedy School of Government alumni
Category:Members of the Ohio House of Representatives
Category:Ohio state senators
Category:Politicians from Cleveland
Category:Women state legislators in Ohio
Category:African-American state legislators in Ohio
Category:21st-century American politicians
Category:21st-century American women politicians | {
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Wednesday, 16 November 2016
Nairobi Rumba Singles Splash
One comfort in an otherwise unsettling year
has been my own luck in finding some great second-hand records – 78rpm, 45rpm
and LPs. I had the good fortune of visiting Nairobi three times this year, and
meeting a long-time Congo-Kenya Rhumba collector who no longer wanted to keep his
vinyl collection, he wanted this music in digital format. So, come the summer
holiday break I will be spending some time keeping my promise to him. Before I share with you my start on that project, I must mention two great compilations
of Kenyan music that have this year been released world-wide. The sound reproduction on both
compilations is really excellent. My personal favourite is “Urgent Jumping: East
African Musiki Wa Dansi Classics” which features 27 tracks spanning close on
two and a half hours of music from Kenyan, Tanzanian and Congolese bands
that plied their trade across the region over the period 1972 - 1982.
“Kenya Special Volume 2” follows the
successful release by Soundway Records of volume one in 2013. This compilation
offers 20 tracks (90 minutes) sampling a wider variety of Kenyan music in the
1970s and 1980s.
Soundway reckon that the resurgence of
interest in African music from the 1960s to the 1980s is boosted by a curious
new generation of music lovers: “The approach to musical rediscovery that is
behind Kenya Special has its origins in a youthful movement of
vinyl collecting (and to some extent club culture), which has, in the past
decade and a half, carved out its own niche alongside the established music
industry.”
“Despite the renewed interest in music from Kenya’s past, finding these tracks
and their rights holders hasn’t become any easier. Only a handful of music
archives around the world harbour collections of Kenyan music, and just a few
private collectors in Kenya and abroad have been sharing catalogue info online
or privately. One of the problems with East African music of this era is that
much of it was originally released only on 45 rpm, seven-inch vinyl singles,
many of which were only ever produced in tiny runs of a few hundred. 45s with
their thin, paper sleeves do not age as well as LPs and are often far more
susceptible to the elements. The compilers of Kenya Special 2 have
gone to great lengths to disclose a small part of what is slowly being accepted
as an essential element of East Africa’s cultural heritage: the history of
recorded popular music.”
So, herewith a rather random sampling from
the pile of 45rpms that Henry sold me. Do leave a comment if you would like
more of the same.
1. Orch Bana Likasi: Lena Pts 1 & 2 (Kanema)
Outstanding vocalist Lovy Mokolo Longomba
was the son of Vicky Longomba, a founding member of OK Jazz. The Muzikifan
website (well worth a visit) tells us that Longomba moved to Nairobi in August
1978 and went through a string of bands, from Les Kinois, through Boma
Liwanza, to Orch Shika Shika. He
then formed the band Super Lovy in
May 1981. Bana Likasi was the same
band as Super Lovy, but was so named
to avoid a contractual conflict. Longomba died in 1996 in a car crash in
Tanzania.
2. Orch. Les Jaca: Sikia Pts 1 & 2 (Ligbutu)
This from the Muzikifan website: “Les Jaca was created by Lovy (Longomba) when
he decided to leave Super Mazembe in 1981. He went into the studio with Siama,
Tabu Frantal, Mandefu, Roy Mosanda and other friends, but the attempt bore no
fruit, so Lovy remained with Super Mazembe.”
3. L'Orch Baba National: Vituko Vya Mama
Mkwe Pts 1 & 2 (Baba Gaston)
One of the first Congolese musicians to
settle in East Africa (in 1971), first in Dar Es Salam, and then in 1976 in
Nairobi. Some reports indicate that Baba Gaston was not the easiest band leader
to work with, and in July 1976 most his band walked out on him to form their
own band, the highly successful Les
Mangalepa. Baba Gaston remained a super star in Nairobi until his
retirement in 1989.
4. Orch Les Wanyika: Nisaidie Baba Pts 1
& 2 (D.J. Ngereza) 1980.
An offshoot of Simba Wanyika formed by a group of Kenyan and Tanzanian musicians
left the band to form Les Wanyika.
Famous for classic Swahili rumba hit hits like Sina Makossa, Paulina and Pamela (these singles were even sold in
South Africa at the time). Band leader and guitarist John Ngereza composed this
song. In 2010, ten years after Ngereza died, four surviving members put aside
their differences and re-grouped and started playing again. You can read about
the reunion of Rashid Juma, Alfani Tommy Malanga, Sijali Zuwa
‘Usikajali’ and Joseph Justy ‘Yellow Man’ here.
Another off-shoot band though the details are not as clear. – this time from Super Volcano. Some sources say that Les Volcano were co-founded by Charles Ray
Kasembe and Mohamed Mazingazinga in 1976. Info on the Kentanza site suggests that Les Volcano came about following the death of Mbaraka Mwinishe (leader of Super Volcano) in 1979. Doug Paterson sees it the same way: "I don't think Les Volcano
was a group until after the death of Mbaraka Mwinshehe. I think Mbaraka
started Super Volcano after leaving Morogoro Jazz (in about 1974?). After
Mbaraka died, Ray Charles Kasembe tried to keep a subset of Super Volcano
members together under the name Les Volcanos. I don't think this group
existed prior to Mbaraka's death (I could be mistaken). I never had the
opportunity to see Super Volcano, though I went to the Kenya coast try to find
them in 1975 (just missed them)." Thanks Doug.
7. Orch. Super Bwambe: Atikapo Pts 1 &
2
Muzikifan tells us that John Negereza of
Les Wanyika was a member of this Congolese band that also included: George
Kalombo Mwanza, sax; John Ngereza, guitar; Chou chou, vocals; Kayembe Nyonga,
vocals; Luboya wa Tshiteyai; Matabu Kunyanga. With Thomy Lomboto, bass, and
Kabeya Ilombo from Viva Makale.
8. Orchestre Matonge: Pesa Moselebende Pts
1 & 2 (Jean-Claude K)
Named after the musical heart of Congo
Kinshasa, this was another of the bands that sold really well in Nairobi. I
cannot find much info on this band, though Tim Clifford on the ever useful
Kentanza Vinyl site says that the Kamanyola label is named “after an area in
eastern DRC Congo close to the Rwandan border. The name featured heavily in
Mobutu’s Zaire as in 1964 it was where the young army officer led troops in the
capture of a rebel-held bridge. When he rose to power, he named the
presidential yacht, an army division and Kinshasa’s sports stadium (now the
Stade des Martyrs) after this victory. There is still a Boulevard Kamanyola in
Lubumbashi. Appropriately enough, one of the roads leading off it is the Avenue
des Chutes - Falls or Collapses Avenue.”
Thanks Chris, I am very excited to hear about this. I am going to download this immediately and woza Friday can start a bit earlier this week. Didn't manage to comment the last months(spamfilter?) , but be sure I have been following you guys from close. Please continue preserving the heritage. Rik | {
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New Year's Day homicide was a 'hit' set up by Port St. Lucie woman over drugs, police say
FORT PIERCE — The New Year’s Day shooting that fatally injured an 18-year-old man was a “hit” set up by a Port St. Lucie woman stemming from an earlier drug rip-off, according to statements made to police.
Fort Pierce police late on New Year’s Day found Jamal Booker face down with gunshot wounds to his head at an apartment complex in the 1200 block of North 29th Street.
More: Four arrests in New Year's Day homicide in Fort Pierce
After a complex investigation with links to Palm Beach, Broward and Miami-Dade counties, four people were charged in the killing.
Affidavits for two of those arrested, Amir Tafari Muhammad, 27, of Wellington; and Megan Nichole Craig, 23, of Port St. Lucie, were sealed, but records relating to the arrest of Dwayne Anthony Fisher, 31, of Coconut Creek, recently were released. Anastasia Benincasa, 17, of Fort Lauderdale, also was arrested in the case.
The Fisher affidavit showed police used surveillance video and determined a Toyota 4Runner backed into a parking space of the Pinecreek Village apartment complex shortly before the shooting.
One person got out and stood in front of a hallway, talking on a phone and smoking. Booker, on his cell phone, walked by as the person who got out of the Toyota pulled a pistol. A second person on the video watched the encounter.
More: Records sealed in New Year's Day fatal shooting of 18-year-old Jamal Booker
Phone call helps police
The first person fired once at Booker from point-blank range, firing two more shots after Booker fell. Both of the people got in the Toyota and left the scene.
Police researched Booker’s phone and found a call seconds before he was shot. Investigators were led to Muhammad, who was released from state prison in March 2018 after an attempted murder conviction, according to court records.
Craig is Muhammad’s girlfriend, who told police she met Booker through the dating site Plenty of Fish “to offer her services as a marijuana dealer,” records said.
More: Port St. Lucie woman charged with murder in shooting death of 18-year-old Fort Pierce man
Craig told investigators she and Booker were supposed to meet Dec. 30 so Booker could buy $900 worth of marijuana, a half pound. She said Booker robbed her of the drugs and Booker said he had a gun.
Craig said she and Muhammad were very upset about the stolen marijuana. Craig said Muhammad told her he was going to kill Booker and she drove him to the apartments to scope out the area.
Plan in place
“She said she knew the plan was for Amir to kill Jamal and then evade police detection,” records said. “Megan confessed to being the person who ultimately set up a hit on Jamal Booker.”
More: Man drives car into house, stabs another man, PSL police say
Fort Pierce police Detective Jeffrey Wachendorfer said on the night of the shooting, investigators believe Fisher and his friend, Muhammad, traveled to the apartment complex in the Toyota 4Runner.
Wachendorfer said Benincasa is Fisher’s girlfriend. Benincasa told investigators that on the day of the killing, she was at a “tattoo party” when Fisher and Muhammad said they wanted to “take care of something.”
Benincasa said she knew they planned on killing someone, and drove them to Fort Pierce.
She said she was in a three-way call with Booker and Muhammad. She said after the shooting, she drove them to Muhammad’s apartment so he could change. They then returned to the “tattoo party.”
Benincasa said they threw the firearm, described as a pink gun, into a canal in Fort Lauderdale.
“She was also upset about how sloppy Amir was, knowing that there was cameras and using his cell phone,” the affidavit said.
While customarily not naming juveniles accused of crimes, TCPalm.com and Treasure Coast Newspapers does name some juveniles depending on the seriousness of the crime, their age, aggravating circumstances and other factors.
Want more Treasure Coast breaking news coverage? If you're already a subscriber to TCPalm, thank you! If not, please subscribe to keep coverage of Treasure Coast breaking news coming. | {
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If this kid is a tweener DE who could be converted to OLB, and put up player of the year numbers in a tough conference, and is projected to go in third through fifth rounds, then Ted Thompson will agonize over picking him or passing on him starting with the 4th or 5th, and then if he's still there trade up in the 6th to take him. Fans of other teams, how do you think your team's GM thinks about this?
ghostfacekillahrabbit:If this kid is a tweener DE who could be converted to OLB, and put up player of the year numbers in a tough conference, and is projected to go in third through fifth rounds, then Ted Thompson will agonize over picking him or passing on him starting with the 4th or 5th, and then if he's still there trade up in the 6th to take him. Fans of other teams, how do you think your team's GM thinks about this?
I mean about Sam, and Ted loves to pick every sort of tweener DE-OLB with a hard-nosed pedigree if he can get a bargain on 'em... That's what i want to hear from serious fans of other teams who pay attention to the inside scoop... what do you think your team's current GM, who you may love or hate or not give a shiat about would think about Sam?
With a high school coach that looks like this, I'm surprised he wasn't scared straight
THAT PIC and its caption:
In junior high school, Craig Smith, the football coach, saw that Sam was athletically blessed and, even better, hungry for guidance and camaraderie. The coaches drafted him to carry equipment and hang around the squad.
My mind immediately played out THE nightmare scenario for how this young man discovered his sexuality.
ghostfacekillahrabbit:ghostfacekillahrabbit: If this kid is a tweener DE who could be converted to OLB, and put up player of the year numbers in a tough conference, and is projected to go in third through fifth rounds, then Ted Thompson will agonize over picking him or passing on him starting with the 4th or 5th, and then if he's still there trade up in the 6th to take him. Fans of other teams, how do you think your team's GM thinks about this?
I mean about Sam, and Ted loves to pick every sort of tweener DE-OLB with a hard-nosed pedigree if he can get a bargain on 'em... That's what i want to hear from serious fans of other teams who pay attention to the inside scoop... what do you think your team's current GM, who you may love or hate or not give a shiat about would think about Sam?
If he is as good a player as they say he is, I could see Seattle taking a flyer on him. We have a large gay community here, Pete Carroll would be like, "hey that's great", and he would have a chance to play if he can really hit. I could see Seattle as a possible destination.
ghostfacekillahrabbit:ghostfacekillahrabbit: If this kid is a tweener DE who could be converted to OLB, and put up player of the year numbers in a tough conference, and is projected to go in third through fifth rounds, then Ted Thompson will agonize over picking him or passing on him starting with the 4th or 5th, and then if he's still there trade up in the 6th to take him. Fans of other teams, how do you think your team's GM thinks about this?
I mean about Sam, and Ted loves to pick every sort of tweener DE-OLB with a hard-nosed pedigree if he can get a bargain on 'em... That's what i want to hear from serious fans of other teams who pay attention to the inside scoop... what do you think your team's current GM, who you may love or hate or not give a shiat about would think about Sam?
By the draft, I may be Browns Gm. I'd take him in the 5th due to size if you convert him. Now if my dog ends up as Browns GM, he's drafting 3 QBs, 2 RBs, and the rest skill players until he finds someone who is slightly below average.
ghostfacekillahrabbit:If this kid is a tweener DE who could be converted to OLB, and put up player of the year numbers in a tough conference, and is projected to go in third through fifth rounds, then Ted Thompson will agonize over picking him or passing on him starting with the 4th or 5th, and then if he's still there trade up in the 6th to take him. Fans of other teams, how do you think your team's GM thinks about this?
He's very much a 3-4 DE, so teams like the Panthers that are pretty well entrenched in the 4-3 aren't going to have as much need for him.
ghostfacekillahrabbit:If this kid is a tweener DE who could be converted to OLB, and put up player of the year numbers in a tough conference, and is projected to go in third through fifth rounds, then Ted Thompson will agonize over picking him or passing on him starting with the 4th or 5th, and then if he's still there trade up in the 6th to take him. Fans of other teams, how do you think your team's GM thinks about this?
The Lions GM is a big fan of taking guys who are really athletic but have something that causes other teams to downgrade them. I could see him overlooking the tweener aspect. No clue, though, about the sexual orientation thing.
meanmutton:ghostfacekillahrabbit: If this kid is a tweener DE who could be converted to OLB, and put up player of the year numbers in a tough conference, and is projected to go in third through fifth rounds, then Ted Thompson will agonize over picking him or passing on him starting with the 4th or 5th, and then if he's still there trade up in the 6th to take him. Fans of other teams, how do you think your team's GM thinks about this?
The Lions GM is a big fan of taking guys who are really athletic but have something that causes other teams to downgrade them. I could see him overlooking the tweener aspect. No clue, though, about the sexual orientation thing.
If he had an injury and/or concussion history, he'd be a sure thing to go to the Lions in the second round.
The party stopped cold. "I couldn't eat no more, so I went to Applebee's to have drinks," Sam Sr. said. "I don't want my grandkids raised in that kind of environment."I'm old school," he added. "I'm a man-and-a-woman type of guy." As evidence, he pointed out that he had taken an older son to Mexico to lose his virginity.
ghostfacekillahrabbit:ghostfacekillahrabbit: If this kid is a tweener DE who could be converted to OLB, and put up player of the year numbers in a tough conference, and is projected to go in third through fifth rounds, then Ted Thompson will agonize over picking him or passing on him starting with the 4th or 5th, and then if he's still there trade up in the 6th to take him. Fans of other teams, how do you think your team's GM thinks about this?
I mean about Sam, and Ted loves to pick every sort of tweener DE-OLB with a hard-nosed pedigree if he can get a bargain on 'em... That's what i want to hear from serious fans of other teams who pay attention to the inside scoop... what do you think your team's current GM, who you may love or hate or not give a shiat about would think about Sam?
In a vacuum he's the exact type of player the Bears under Emery would take a good look at. In reality, they've already got one tweener they don't know what to do with (McClellen) so despite an awful defense in need of upgrades, there's no way they'll even consider him.
JusticeandIndependence:The party stopped cold. "I couldn't eat no more, so I went to Applebee's to have drinks," Sam Sr. said. "I don't want my grandkids raised in that kind of environment."I'm old school," he added. "I'm a man-and-a-woman type of guy." As evidence, he pointed out that he had taken an older son to Mexico to lose his virginity.
FTA "A sister drowned when she was 2, before Michael was born, when another child accidentally knocked her off a fishing pier. Another brother, Russell, was 15 when he was shot and killed trying to break into a home, in what his father said was part of a gang initiation. Another brother, Julian, has not been heard from since he left for work one day in 1998; his family believes he is dead. Two others are in jail. "HIs mother " JoAnn is a member of the Jehovah's Witnesses, who do not celebrate holidays or believe in most birth control and generally shun participation in organized sports. Michael Sr. comes from a large Baptist family, and his father was a long-serving deacon at a church in nearby Texas City, Tex. "
I bet coming out is one of the easier things this guy has gone through.
ghostfacekillahrabbit:If this kid is a tweener DE who could be converted to OLB, and put up player of the year numbers in a tough conference, and is projected to go in third through fifth rounds, then Ted Thompson will agonize over picking him or passing on him starting with the 4th or 5th, and then if he's still there trade up in the 6th to take him. Fans of other teams, how do you think your team's GM thinks about this?
I think he'd fit in well with the Steelers defense, they typically like those hybrids to play their rush positions in the 3-4. But they just drafted one (Jarvis Jones) last year so I doubt they're thinking about him anytime before round 3 or 4. I don't think they'd have a problem drafting him because of his penis preference but who really knows? Scouts, GMs, and owners especially tend to be old white guys, otherwise known as the most likely demographic to have a problem with gay people.
I like to think the NFL is a meritocracy (Tebow phenom excluded) and that if he's good enough my team would take him. What I'm not excited about is if he goes to the combine and stinks it up, runs a 5.2 or something, and he drops way down in the draft. That shiatstorm won't be fun to hear about. I hope he dominates the combine and leaves no question he can play in the NFL.
Semper IvXx:ghostfacekillahrabbit: If this kid is a tweener DE who could be converted to OLB, and put up player of the year numbers in a tough conference, and is projected to go in third through fifth rounds, then Ted Thompson will agonize over picking him or passing on him starting with the 4th or 5th, and then if he's still there trade up in the 6th to take him. Fans of other teams, how do you think your team's GM thinks about this?
I think he'd fit in well with the Steelers defense, they typically like those hybrids to play their rush positions in the 3-4. But they just drafted one (Jarvis Jones) last year so I doubt they're thinking about him anytime before round 3 or 4. I don't think they'd have a problem drafting him because of his penis preference but who really knows? Scouts, GMs, and owners especially tend to be old white guys, otherwise known as the most likely demographic to have a problem with gay people.
I like to think the NFL is a meritocracy (Tebow phenom excluded) and that if he's good enough my team would take him. What I'm not excited about is if he goes to the combine and stinks it up, runs a 5.2 or something, and he drops way down in the draft. That shiatstorm won't be fun to hear about. I hope he dominates the combine and leaves no question he can play in the NFL.
If you think that old white guys are the ones most likely to have a problem with gay men, you haven't met many old black guys.
meanmutton:Semper IvXx: ghostfacekillahrabbit: If this kid is a tweener DE who could be converted to OLB, and put up player of the year numbers in a tough conference, and is projected to go in third through fifth rounds, then Ted Thompson will agonize over picking him or passing on him starting with the 4th or 5th, and then if he's still there trade up in the 6th to take him. Fans of other teams, how do you think your team's GM thinks about this?
I think he'd fit in well with the Steelers defense, they typically like those hybrids to play their rush positions in the 3-4. But they just drafted one (Jarvis Jones) last year so I doubt they're thinking about him anytime before round 3 or 4. I don't think they'd have a problem drafting him because of his penis preference but who really knows? Scouts, GMs, and owners especially tend to be old white guys, otherwise known as the most likely demographic to have a problem with gay people.
I like to think the NFL is a meritocracy (Tebow phenom excluded) and that if he's good enough my team would take him. What I'm not excited about is if he goes to the combine and stinks it up, runs a 5.2 or something, and he drops way down in the draft. That shiatstorm won't be fun to hear about. I hope he dominates the combine and leaves no question he can play in the NFL.
If you think that old white guys are the ones most likely to have a problem with gay men, you haven't met many old black guys.
I think there aren't old black owners. Not sure about GMs, though there probably are scouts.
Hey NYT (and the rest of the media), thanks for helping to make the life of this guy, his family, his coach, and everyone who knew him a living hell because he had the guts to come out as gay. You really deserve a lot of credit. My two local sports stations haven't STFU about him for three days now. No idea what's going on in the Olympics or the NBA.
ghostfacekillahrabbit:If this kid is a tweener DE who could be converted to OLB, and put up player of the year numbers in a tough conference, and is projected to go in third through fifth rounds, then Ted Thompson will agonize over picking him or passing on him starting with the 4th or 5th, and then if he's still there trade up in the 6th to take him. Fans of other teams, how do you think your team's GM thinks about this?
Well, Elway came out and said the right things, but I highly doubt after Denver's experience with Tebowmania he would want to deal with the media and the distractions Sam would bring. Very doubtful the Broncos would draft him, regardless of 'fit'.
not sure what "being straight" has to do with buying prostitution to end your son's virginity... ever thought of ya know, dating a girl?
Ow! That was my feelings!:ghostfacekillahrabbit: If this kid is a tweener DE who could be converted to OLB, and put up player of the year numbers in a tough conference, and is projected to go in third through fifth rounds, then Ted Thompson will agonize over picking him or passing on him starting with the 4th or 5th, and then if he's still there trade up in the 6th to take him. Fans of other teams, how do you think your team's GM thinks about this?
Well, Elway came out and said the right things, but I highly doubt after Denver's experience with Tebowmania he would want to deal with the media and the distractions Sam would bring. Very doubtful the Broncos would draft him, regardless of 'fit'.
the best decision Elway has made so far is bringing in Peyton, after he retires that team will be a hot mess
ironically i think the Bears could draft him, their non-existent pass-rush needs all the help it can get, the Ravens are another candidate with Suggs possibly being a Cap casaulty
skrame:meanmutton: I like to think the NFL is a meritocracy (Tebow phenom excluded)
C'mon, man...
Please explain how, based only on his college career, Tebow didn't merit a chance in the NFL.
/obviously he didn't prove that he had what it takes to stay in the NFL, but it looks like you're talking about the draft and a shot at the NFL.
I wasn't talking about the draft in relation to Tebow. I didn't say he didn't deserve a chance, and regardless if I did or not, not only did he get a chance he got drafted about 5 rounds early. He got a chance and sucked, yet kept his job (for a bit anyway) and was treated as if he didn't suck, at least by the media and some weirdly over zealous Tebowners who felt the need to white knight him online.
My point was he was an outlier in a bottom line business. But you certainly protected his honor from imaginary insults.
So a black man chooses his farked up values over his unconditional love for his son. The same values some dicks trumpeted to put his people in chains 150 years ago. This kind of shiat makes my brain hurt. Also interesting to note that most anti-gay quotes from the bible are from Leviticus. Which also say its cool to rape a biatch but if you knock her up you have to marry her or buy her dad a donkey. Truly values to base your life on.
BowtoMogul:FTA "A sister drowned when she was 2, before Michael was born, when another child accidentally knocked her off a fishing pier. Another brother, Russell, was 15 when he was shot and killed trying to break into a home, in what his father said was part of a gang initiation. Another brother, Julian, has not been heard from since he left for work one day in 1998; his family believes he is dead. Two others are in jail. "HIs mother " JoAnn is a member of the Jehovah's Witnesses, who do not celebrate holidays or believe in most birth control and generally shun participation in organized sports. Michael Sr. comes from a large Baptist family, and his father was a long-serving deacon at a church in nearby Texas City, Tex. "
I bet coming out is one of the easier things this guy has gone through.
Holy hell. You'd think the parents would have realized their values led them to being some of the worst parents in history and chilled out a bit.
Ow! That was my feelings!:ghostfacekillahrabbit: If this kid is a tweener DE who could be converted to OLB, and put up player of the year numbers in a tough conference, and is projected to go in third through fifth rounds, then Ted Thompson will agonize over picking him or passing on him starting with the 4th or 5th, and then if he's still there trade up in the 6th to take him. Fans of other teams, how do you think your team's GM thinks about this?
Well, Elway came out and said the right things, but I highly doubt after Denver's experience with Tebowmania he would want to deal with the media and the distractions Sam would bring. Very doubtful the Broncos would draft him, regardless of 'fit'.
Dude, Elwsy's best defensive player is a knucklehead. He was suspended for violating the drug policy and has done some seriously immature shiat off the field.
Elway got rid of Tebow because his stock was never going to be higher and he wasn't that good. Plus Peyton.
I see the Broncos, Steelers, Pats, Hawks, Niners, and Giants amongst others that would be good places for Sam to land just because they are stable teams and can tell folks to STFU. | {
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Q:
r - add multiple markers to rMaps
Question
How do you add multiple markers using rMaps?
Data
coords <- structure(list(stop_id = 19841:19843, stop_name = c("Flagstaff Railway Station (Melbourne City)",
"Melbourne Central Railway Station (Melbourne City)", "Parliament Railway Station (Melbourne City)"
), stop_lat = c(-37.8119813073807, -37.8099387667386, -37.8110540555305
), stop_lon = c(144.955653760429, 144.962593535096, 144.972910916416
)), .Names = c("stop_id", "stop_name", "stop_lat", "stop_lon"
), sorted = "stop_id", row.names = 17:19, class = c("data.table",
"data.frame"))
Examples
Using library(rMaps) I can create a map and add a single marker, as per the examples on Ramnath's github page:
library(rMaps)
l <- Leaflet$new()
l$setView(c(-37.8602828, 145.079616), zoom=11)
l$tileLayer(provider = "Acetate.terrain")
## add one marker:
l$marker(LatLng = c(-37.81198,144.9557))
But I can't figure out how to add multiple markers from the coords data frame, without writing a l$marker line for each one.
I've tried to use GeoJSON but I'm new to this so haven't got my head around it yet and must be doing something wrong.
# library(rgdal)
# coords.sp <- SpatialPointsDataFrame(coords[,.(stop_lon, stop_lat)], coords[,.(stop_id, stop_name)])
# writeOGR(obj=coords.sp, dsn='coords.geojson', layer='OGRGeoJSON', driver='GeoJSON')
# gj <- readOGR("./coords.geojson", layer="OGRGeoJSON")
# l$geoJson(gj)
# l$geoJson("./coords.geojson")
I'm happy to use JSON/GeoJSON if it's the way to go.
Desired output
I would like the result to be the same as if I used library(leaflet) to show multiple markers
library(leaflet)
leaflet() %>%
addProviderTiles("Acetate.terrain") %>%
setView(lat = -37.8602828, lng = 145.079616, zoom=11) %>%
addMarkers(data=coords, lat=~stop_lat, lng=~stop_lon)
GeoJSON
Here is the GeoJSON code that's produced from the writeOGR command, and I've validated it at GeoJSONLint
{
"type": "FeatureCollection",
"features": [
{ "type": "Feature", "id": 1, "properties": { "stop_id": 19841, "stop_name": "Flagstaff Railway Station (Melbourne City)" }, "geometry": { "type": "Point", "coordinates": [ 144.955653760428987, -37.811981307380698 ] } },
{ "type": "Feature", "id": 2, "properties": { "stop_id": 19842, "stop_name": "Melbourne Central Railway Station (Melbourne City)" }, "geometry": { "type": "Point", "coordinates": [ 144.962593535096005, -37.809938766738597 ] } },
{ "type": "Feature", "id": 3, "properties": { "stop_id": 19843, "stop_name": "Parliament Railway Station (Melbourne City)" }, "geometry": { "type": "Point", "coordinates": [ 144.972910916415998, -37.811054055530498 ] } }
]}
A:
I can make use of library(geojsonio) to correctly read the GeoJSON file, and then use l$geoJson to load the markers onto the map
## create spatial object and save as GeoJSON
# library(rgdal)
coords.sp <- SpatialPointsDataFrame(coords[,.(stop_lon, stop_lat)], coords[,.(stop_id, stop_name)])
writeOGR(obj=coords.sp, dsn='coords.geojson', layer='OGRGeoJSON', driver='GeoJSON')
l <- Leaflet$new()
l$setView(c(-37.8602828, 145.079616), zoom=11)
l$tileLayer(provider = "Acetate.terrain")
## Read the GeoJSON data
library(geojsonio)
gj <- geojson_read("./coords.geojson")
l$geoJson(gj)
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41 F.3d 35
74 A.F.T.R.2d 94-7036
UNITED STATES of America, Appellee,v.Lawrence MACCHIA, Defendant-Appellant.
No. 1037, Docket 94-1497.
United States Court of Appeals,Second Circuit.
Submitted Oct. 17, 1994.Decided Oct. 19, 1994.Filed Nov. 21, 1994.
Gerald B. Lefcourt, Joshua L. Dratel, Lefcourt & Dratel, P.C., New York City, for defendant-appellant.
Robert E. Lindsay, Dept. of Justice, Washington, DC, for appellee.
Before: NEWMAN, Chief Judge, ALTIMARI and LEVAL, Circuit Judges.
JON O. NEWMAN, Chief Judge:
1
This interlocutory appeal in a criminal case endeavors to secure pretrial review of a ruling denying a motion to dismiss an indictment alleged to have been returned in violation of an immunity agreement. The appeal is brought by Lawrence Macchia from the August 24, 1994, ruling of the District Court for the Eastern District of New York (Leonard D. Wexler, Judge), 861 F.Supp. 182, construing the immunity agreement to have conferred only derivative use immunity and not transactional immunity. We conclude that recent Supreme Court pronouncements have altered the law of this Circuit, which formerly permitted such interlocutory appeals, and we therefore dismiss the appeal for lack of appellate jurisdiction.
Background
2
Macchia and seven co-defendants were indicted for conspiracy to defraud the United States, 18 U.S.C. Sec. 371, and attempting to evade excise taxes, 26 U.S.C. Sec. 7201, in connection with an alleged scheme to avoid paying federal gasoline taxes. The offenses are detailed in United States v. Macchia, 35 F.3d 662 (2d Cir.1994), an unsuccessful pretrial appeal by two of Macchia's co-defendants claiming insulation from trial on double jeopardy grounds. Macchia sought to prevent his trial on the basis of an immunity agreement containing the following language:
3
Any truthful statements made by Lawrence Macchia in response to questions asked of him by government attorneys and agents during this interview or any information arising from or relating thereto will not be used against Lawrence Macchia in any criminal prosecution by the United States government, or by the State of New York, or its political subdivisions (emphasis added).
4
Macchia contended in the District Court that the emphasized words, especially the words "or relating thereto," added at the insistence of his counsel, broadened the agreement beyond use immunity and, in effect, conferred transactional immunity since any evidence relevant to the charge against him would necessarily "relat[e] to" his statements. Judge Wexler disagreed, denied the motion to dismiss, and also ruled that a so-called Kastigar hearing, see Kastigar v. United States, 406 U.S. 441, 92 S.Ct. 1653, 32 L.Ed.2d 212 (1972), to determine whether the protection of derivative use immunity was observed, would be deferred until after the trial. This appeal followed.
5
On September 23, 1994, the Government moved to dismiss for lack of appellate jurisdiction. After considering opposing papers and with the scheduled trial date approaching, we issued an order on October 19, 1994, granting the motion to dismiss and indicating that an opinion would follow. We now issue that opinion.
Discussion
6
The Government contends that a pretrial interlocutory appeal is not available to consider a defendant's claim that an immunity agreement has conferred insulation from trial. This jurisdictional issue has evoked varying responses from courts. Compare United States v. Abbamonte, 759 F.2d 1065 (2d Cir.1985) (order denying dismissal of indictment on ground of prior plea agreement appealable), with United States v. Bird, 709 F.2d 388 (5th Cir.1983) (order denying dismissal of indictment on ground of prior plea agreement not appealable), and United States v. Eggert, 624 F.2d 973 (10th Cir.1980) (same). The disagreement has stemmed from uncertainty as to the continued force of the Supreme Court's 1910 decision in Heike v. United States, 217 U.S. 423, 30 S.Ct. 539, 54 L.Ed. 821 (1910). In Heike, the Supreme Court unequivocally rejected an interlocutory appeal in the context of a claim of statutory immunity flowing from a grand jury appearance, 217 U.S. at 433, 54 S.Ct. at 542-43. Sixty-seven years later, however, the continued force of that decision was put in doubt by Abney v. United States, 431 U.S. 651, 97 S.Ct. 2034, 52 L.Ed.2d 651 (1977), which allowed an interlocutory appeal of an adverse double jeopardy ruling. Abney rendered Heike uncertain because Heike had explicitly relied on the unavailability of pretrial appeals to challenge adverse double jeopardy rulings. Heike, 217 U.S. at 432, 54 S.Ct. at 542.
7
The tension between Abney and Heike began to be resolved the year after Abney was decided. In United States v. MacDonald, 435 U.S. 850, 98 S.Ct. 1547, 56 L.Ed.2d 18 (1978), the Court ruled that an interlocutory appeal was not available from a ruling denying a motion to dismiss for alleged violation of the Sixth Amendment right to a speedy trial. Though the speedy trial claim, if upheld in the trial court, would have insulated the defendant from having to defend against the criminal charges, the Court ruled that the Sixth Amendment right would be adequately vindicated by a reversal of the conviction on appeal from a final judgment. In a footnote, the Court pointed out that not every claim that, if successful, would require dismissal of an indictment may be the basis for interlocutory review, and cited Heike, presumably as an example of claims that must await post-conviction review. Id. at 860 n. 7, 98 S.Ct. at 1552-53 n. 7. However, the MacDonald footnote did not comment on the fact that Abney had allowed pre-conviction appeal of a double jeopardy claim, the analogy on which Heike had relied.
8
More recently, in Midland Asphalt Corp. v. United States, 489 U.S. 794, 109 S.Ct. 1494, 103 L.Ed.2d 879 (1989), the Court elevated the language of the MacDonald footnote to the text, id. at 801, 109 S.Ct. at 1499, and gave a very strong signal that a rejected immunity claim may not be raised on an interlocutory appeal. Midland Asphalt ruled that an interlocutory appeal was not available to challenge the denial of a motion to dismiss an indictment on the ground of an alleged violation by the Government of Rule 6(e) of the Federal Rules of Criminal Procedure. The Court explained that interlocutory appeal may occur not merely when the right at issue, if vindicated, will result in dismissal of the indictment, but only when the right at issue is itself a constitutional or statutory right not to be tried, such as the protections of the Double Jeopardy Clause, see Abney v. United States, supra, or the Speech or Debate Clause, see Helstoski v. Meanor, 442 U.S. 500, 99 S.Ct. 2445, 61 L.Ed.2d 30 (1979).
9
It is arguable that an immunity claim satisfies even the limited right of interlocutory appeal recognized in Midland Asphalt. The argument would be at its strongest if the immunity claim were grounded on statutory insulation, such as that formerly contained in 18 U.S.C. Sec. 3486, repealed by Pub.L. 91-452, tit. II, Sec. 228(a), 84 Stat. 930 (1970). See Ullmann v. United States, 350 U.S. 422, 76 S.Ct. 497, 100 L.Ed. 511 (1956). Statutes such as former section 3486, which conferred transactional immunity, typically provided that "no such [immunized] witness shall be prosecuted." 18 U.S.C. Sec. 3486(c). Such a prohibition seems to be an "explicit statutory ... guarantee that trial shall not occur," Midland Asphalt, 489 U.S. at 801, 109 S.Ct. at 1499. Nevertheless, we cannot ignore the fact that Midland Asphalt quoted with approval the MacDonald footnote's reference to the unavailability of an interlocutory appeal to challenge immunity claims:
10
"Dismissal of the indictment is the proper sanction when a defendant has been granted immunity from prosecution, when his indictment is defective, or, usually, when the only evidence against him was seized in violation of the Fourth Amendment. Obviously, however, this has not led the Court to conclude that such defendants can pursue interlocutory appeals." MacDonald, supra, 435 U.S. at 860 n. 7, 98 S.Ct. at 1552-53 n. 7.
11
Midland Asphalt, 489 U.S. at 801, 109 S.Ct. at 1499. Apparently, the insulation from prosecution, and thus from trial, provided by a transactional immunity statute (like the one in Heike, 217 U.S. at 426, 30 S.Ct. at 540), is not the "explicit statutory ... guarantee that trial will not occur" that Justice Scalia had in mind.
12
The pending case presents a weaker claim for interlocutory appeal than would arise from a claim grounded on a statute explicitly insulating from prosecution a witness given transactional immunity. Macchia relies not on a statute conferring transactional immunity, but rather on an alleged agreement with the United States Attorney, the breach of which, he contends, violates the Due Process Clause of the Fifth Amendment. There can be virtually no doubt that a violation of the general prohibition of the Due Process Clause is not a violation of an "explicit statutory or constitutional guarantee that trial will not occur," as that phrase is used in Midland Asphalt.
13
The appellant seeks to draw comfort from the fact that his argument is grounded on a constitutional protection--the Due Process Clause, but that argument misses Justice Scalia's point. The test is not whether the right alleged to be impaired is grounded in the Constitution; MacDonald's claim, for which interlocutory appeal was denied, was based on the Sixth Amendment. The test is whether the pertinent protection, constitutional or statutory, explicitly guarantees a right not to be tried.
14
In this Circuit, we have heretofore permitted interlocutory appeals to assert breach of plea agreements alleged to confer immunity. See United States v. Abbamonte, 759 F.2d at 1070-71, United States v. Alessi, 544 F.2d 1139 (2d Cir.) (Alessi III ), cert. denied, 429 U.S. 960, 97 S.Ct. 384, 50 L.Ed.2d 327 (1976); United States v. Alessi, 536 F.2d 978 (2d Cir.1976) (Alessi I ). Alessi I, which predated Abney, allowed the interlocutory appeal, analogizing, for appeal purposes, claims based on immunity provisions of plea agreements to double jeopardy claims. 536 F.2d at 980 (relying on United States v. Beckerman, 516 F.2d 905 (2d Cir.1975)). In Alessi III, which reached us after certiorari had been granted in Abney, Abney v. United States, 426 U.S. 934, 96 S.Ct. 2646, 49 L.Ed.2d 385 (1976) (granting certiorari), the appealability issue evoked a strong opinion by Judge Friendly, arguing against pretrial review of double jeopardy and immunity claims. This view was evidently not shared by Judge Feinberg, who concurred in the result on the appealability issue. Alessi III, 544 F.2d at 1155. Though Judge Friendly, and Judge Van Graafeiland, who concurred in Judge Friendly's opinion, would have disallowed the interlocutory appeal and followed Heike "[i]f the point were open in this circuit," id. at 1152, they felt bound by Alessi I.
15
When the issue arose again after Abney, we said in Abbamonte that "[w]e are obliged to follow the holding on appealability in Alessi [I and III ] unless we have some basis for concluding that that ruling has been eroded by subsequent decisions of the Supreme Court." 759 F.2d at 1071. We did not find such erosion in Abney, and, though the MacDonald footnote had cited Heike, we evidently concluded that there was an insufficient basis for considering the law of this Circuit to have been altered. Now, however, Midland Asphalt has sent a clear message that at least an immunity claim grounded on the Due Process Clause, as we have in the pending case, and very likely an immunity claim grounded on a statute conferring transactional immunity, as in Heike, can no longer be raised on an interlocutory appeal. In Midland Asphalt, the Supreme Court has not only promoted to text the MacDonald footnote, which had cited Heike, but has also provided the explicit rationale that an interlocutory appeal will lie in the criminal context only where the constitutional or statutory protection relied upon confers a right not to be tried, as distinguished from a right to be free of some adverse action for which the remedy is dismissal of the indictment. Moreover, we need not consider the merits of appellant's claim for transactional immunity in order to determine our appellate jurisdiction: even if he is right that his immunity agreement should be construed to confer transactional immunity, his claim for dismissal of the indictment would still rest on the general prohibition of the Due Process Clause, rather than an immunity statute explicitly protecting the right not to be tried.
16
We therefore conclude that the appealability rulings in Alessi I, Alessi III, and Abbamonte have been eroded, and we overrule those rulings and dismiss this appeal for lack of appellate jurisdiction.1
1
This opinion has been circulated to the active judges of the Court
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A Life Table for Liriomyza trifolii (Diptera: Agromyzidae) in a Temperate Zone of Northeast Egypt With Key Factor Analysis.
The American serpentine leaf miner, Liriomyza trifolii (Burgess) (Diptera: Agromyzidae), is a perennial pest of leguminous crops in the Mediterranean region. A life table was constructed for L. trifolii infesting broad bean, Vicia faba L., in northern Egypt. Key factor analysis was used to rank sources of immature mortality over two seasons. Leaf miners had three successive generations, and a partial fourth, in each year, with peak abundance in March-April. Less than 15 and 22% of L. trifolii survived to adult in seasons one and two, respectively. The largest contributor of immature leaf miner mortality in both seasons was unknown (41.2 and 39.1% of total mortality, respectively), and likely comprised a combination of abiotic factors, parasitoid-inflicted mortality (host-feeding), and predation. Parasitism was second, contributing 36.2 and 35.6% of total mortality in the two seasons, respectively, primarily due to larval parasitism by Diglyphus isaea (Walker) (Hymenoptera: Eulophidae), and low levels of larval-pupal parasitism by Opius pallipes Wesmael (Hymenoptera: Braconidae) and Halticoptera circulus (Walker) (Hymenoptera: Pteromalidae). Residual mortality resulted from malformed pupae or failed adult emergence. Key factor analysis revealed malformation to be the major cause of pupal mortality. Sequential regression confirmed that unknown mortality and D. isaea were the top stage-specific factors, both acting on larvae. Parasitoid abundance tracked host abundance across generations, but density dependence was not observed for any mortality factor, and the magnitudes of regression slopes were small. The results indicate the potential importance of conservation biological control in management of L. trifolii, given that naturally occurring parasitoids and other biotic/abiotic factors exert significant mortality on immature leaf miners. | {
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SF examines impacts of its many budget set-asides
Supervisors Katy Tang and Aaron Peskin at a Board of Supervisors meeting last year. Supervisors Katy Tang and Aaron Peskin at a Board of Supervisors meeting last year. Photo: Gabrielle Lurie, Special To The Chronicle Photo: Gabrielle Lurie, Special To The Chronicle Image 1 of / 1 Caption Close SF examines impacts of its many budget set-asides 1 / 1 Back to Gallery
San Francisco lawmakers are beginning to take a hard look at the long-term consequences of the city’s abundant use of budget set-asides — voter-approved ballot measures that mandate how the government spends money on specific projects.
Since the mid-1990s, the amount of money San Francisco has allocated based on voter-adopted initiatives has ballooned dramatically, according to a report compiled by the city controller’s office. That has alarmed some city supervisors.
In the next five years, the report said, San Francisco will spend $1.6 billion on set-asides— 30 percent of the city’s $5 billion general fund, its primary source of discretionary funding. Self-supporting departments such as the airport comprise the remainder of the city’s $10.1 billion budget.
That’s a sharp increase from just over a decade ago. By comparison, in the 1994-95 fiscal year city spending on set-aside initiatives was $200 million, according to the report.
At a hearing before the Budget and Finance Committee Tuesday, Supervisors Katy Tang and Aaron Peskin expressed concern about constraints the set-asides place on policymakers as budget priorities shift year to year.
While set-asides provide a fixed amount of funding for essential city services, like transportation and libraries, once funding is locked up by the voters, city officials are essentially powerless to make adjustments, Tang said.
“Future boards of supervisors and mayors essentially have their hands tied for many of these measures,” she said. “We don’t have the ability to be flexible in these funding decisions.”
San Francisco currently has 19 set-aside mandates, far more than any other large city in the state, according to the controller’s office. In fact, local governments in the rest of California have a total of 10 similar funding requirements.
“For comparison to other cities, Los Angeles has two adopted requirements, San Diego has one and San Jose has none,” the controller’s report said.
Most of San Francisco’s set-aside requirements — nearly $418 million — are allocated for the Municipal Transportation Agency.
“All of the set-asides are for remarkably worthy causes, but it really constrains the city, the Board of Supervisors and the mayor from being able to make tough decisions on an annual basis,” Peskin said. “It’s the easy way out — it doesn’t require us to look for new sources of revenues” and it “constrains the ability to govern and allocate money in the best and most mature way that’s most responsive to the needs of the day.”
City officials on Tuesday briefly discussed placing expiration dates on all existing set-asides, which would allow legislators to reconsider spending mandates after a period of time. Such a move would have to be approved by voters. Currently, only 10 of the city’s 19 set-asides have fixed expiration dates.
“My goal is to work on a set of policies to address our spending” set-asides, Tang said.
Dominic Fracassa is a San Francisco Chronicle staff writer. Email: [email protected] Twitter: @dominicfracassa | {
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We have moved. Please visit as Imaginative Worlds await.
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Many LGBT youth who are rejected by their own families often encounter prejudice, harassment and abuse when they shift to a foster home. Photo: FIle
Many LGBT youth who are rejected by their own families often encounter prejudice, harassment and abuse when they shift to a foster home. Photo: FIle
New research claims that homeless youth that are LGBTQ are twice as likely to face homelessness than straight youth, and those who are homeless are at a significantly higher risk of violence and death compared to straight youth.
The study, from Chapin Hall at the University of Chicago, included a phone survey of 26,161 youth across over 22 counties, as well as 215 in-depth interviews with LGBTQ-identified homeless kids. This is the second in a series of briefs done as part of the Voices of Youth Count project, attempting to link evidence and action in an effort to end youth homelessness.
LGBT youth were shown to face a higher percentage of risky conditions on the streets, including being 15% more likely to be physically harmed, 10% more likely to self-harm, and 18% more likely to exchange sex for basic needs.
Discrimination both within and outside their family was also far more likely, with 64% of LHBTQ youth reporting such from their family, and 60% outside of it. This compared to only 37% of straight youth reporting either.
Further, race also played a part, with youth who are black or multiracial and LGBTQ being 16% more likely to be homeless, versus only 4% for white, straight youth.
Matthew Morton, the principal Investigator for Voices of Youth Count, wants to offer up a silver lining. “The findings are a bit grim, but hopefully it will galvanize communities to help these young people.
This is a very resilient population, and many expressed hope that they can rise above their circumstances,” he continued. “The message here is really from the youth themselves – if we listen to them and offer help where it’s needed, they can make great progress.”
In the first Voices of Youth Count Study, from 2017, it was discovered that one in thirty 13-17 year olds had been homeless at some point in the year before. | {
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This is a personal fitness & running inspiration blog. I am an active runner who loves to share my experiences--the good & the bad. Please connect with me if you have questions or would like to know more!
Categories
May 7 Weekly Workouts [week 245]
Just not feeling it last week. I am hoping that I will gain some momentum this week, even while traveling!
Week 245
Sunday, 4.29:Rested, but walked a ton around Seattle!Monday, 4.30: Was going to run, but the gym was packed this morning at the hotel. Instead I did a back+bicep workout which was good!Tuesday, 5.1: Got to the gym early enough to run 1 mile on the treadmill!! It felt really good, even if my time was a little slower at 10:45 :)Wednesday, 5.2:Ran 1 mile on the treadmill again in 10:40!! And then we walked a ton more around Seattle before heading home :)Thursday, 5.3: I did not get up for an early morning workout and then had a bit of an emotional meltdown after work....so I skipped my kettlebell class, too. I needed the break.Friday, 5.4: Skipped today.Saturday, 5.5:Ran the Derby Day 5K in 36:32--I knew it wouldn't be a great race, but I'm still glad I finished. I also ran/walked there and back for an additional 3ish miles!! | {
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GENOME ANNOUNCEMENT
===================
Guinea pig cytomegalovirus (GPCMV) is a model for congenital CMV infection, an important cause of disability in newborns ([@B1]). Strain 22122, isolated by Hartley in 1957 (ATCC, VR-682), is the only characterized GPCMV strain ([@B2]). Salivary gland (SG) extracts are pathogenic, while tissue culture (TC)-passaged viruses are significantly attenuated. Existing genomic sequences were derived from TC-adapted GPCMV ([@B3]) or ATCC virus (AB592928), which was also passaged multiple times in cell culture prior to submission to ATCC ([@B4]). Therefore, we sought to determine the sequence of pathogenic GPCMV, obtained originally from the ATCC strain 21222 stock but maintained exclusively by serial passage in animals. Sequencing was performed directly on DNA purified from the SG homogenate, with no intervening passage in TC.
Approximately 35 serial SG passages were made in animals over a 25-year period (1985 to 2010) in Cincinnati, OH, and Minneapolis, MN, in strain 2 guinea pigs. SG tissue was minced, homogenized, clarified by centrifugation, and stored at −80°C. 350 PFU of this SG stock has been shown to produce efficient fetal infection and disease ([@B5]). Virions in the SG homogenate were pelleted by ultracentrifugation; treated with DNase, proteinase K, and RNase; phenol/chloroform extracted; alcohol precipitated; and sequenced on an Illumina Genome Analyzer. 119,721,518 raw reads were obtained; reads under 70 bp were discarded. Of the remaining 83,249,482 reads, 30,674,158 matched AB592928, which was used as a template to assemble the full-length SG sequence. Average coverage was 9,609.
Initial comparison of the SG sequence to AB592928 suggested deletions within a ∼1.2-kb region of complex repeats thought to comprise the GPCMV origin of replication. Given the short lengths of the Illumina reads, these apparent deletions likely represented artifacts of sequence assembly, as within repeated sequences the assembly software could not orient overlapping reads to properly reconstruct the region. To address this concern, SG homogenate was PCR amplified using primers flanking the repeat region (5′-TGG GTG TGG GAG TGG CTT TG-3′ and 5′-TCG GTC TGG ATG CGT GTT G-3′) with Vent polymerase, and multiple independently isolated clones were sequenced. The size of the PCR product (∼1.2 kb) was consistent with that predicted from AB582828 and, following TA cloning and Sanger sequencing, this sequence was incorporated into the final SG sequence.
Comparison of the AB592928 with SG-22122 revealed eleven differences: four nucleotide substitutions, one clarification of an ambiguous base, one nucleotide insertion, and five 1- to 2-nucleotide differences in poly(T) tracts. None of the differences altered codons in currently annotated open reading frames.
We annotated an alternative start codon for *gp148*, a major histocompatibility complex (MHC) I homolog. This removed a cluster of sixteen 7-bp repeats near the 5′ end of the previous annotation, resulting in a shorter protein of 350 amino acids (aa). Other putative open reading frames (ORFs) are similar between the SG-22122 and AB592928 sequences, with the exception that analysis of SG-22122 revealed two additional previously unannotated gp138 family ORFs (gp138.1, gp138.3). All three members of this gp138 ORF cluster were noted to bear predicted structural similarity to immunoglobulin variable (IgV) domains from the Ig superfamily of proteins, suggesting a potential role for these gene products in immune evasion/immune modulation.
In summary, the sequence of the pathogenic SG genome reveals surprisingly few differences from ATCC stock. A similar level of stability has been noted upon whole-genome sequencing for murine CMV ([@B6]). For GPCMV, attenuation following tissue culture passage may be related to deletions in key pathogenesis genes ([@B7]). Additional studies are required to elucidate the molecular basis of GPCMV attenuation following TC adaptation.
Nucleotide sequence accession number. {#h1}
-------------------------------------
The genome sequence for this strain has been deposited with GenBank under the accession number [KC503762](KC503762).
**Citation** Yang D, Tamburro K, Dittmer D, Cui X, McVoy MA, Hernandez-Alvarado N, Schleiss MR. 2013. Complete genome sequence of pathogenic guinea pig cytomegalovirus from salivary gland homogenates of infected animals. Genome Announc. 1(2):e00054-13. doi:10.1128/genomeA.00054-13.
This work was supported by NIH grants CA019014, HD044864, and HD038416.
Helpful discussions with Martin G. Myers, Galveston, TX, are gratefully acknowledged (M.R.S.).
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A federal appeals court handed Florida Gov. Rick Scott a decisive victory this week when it temporarily blocked a federal judge’s ruling that urged the state’s executive clemency board to overhaul its “fatally flawed” process of restoring felons’ voting rights by Thursday.
Why it matters: The order issued late Wednesday, which affects an estimated 1.5 million convicted felons, comes as reform advocates have been fighting to restore their voting rights for nearly two decades.
People with past felony convictions are permanently barred from voting, and they have to wait up to eight years to request Scott and the clemency board to consider restoring it.
Felony disenfranchisement laws affect about six million nationally, but Florida, which remains the most stringent, bans more people from voting than any other state.
Timeline:
September 2000: A federal class-action lawsuit against then-Gov. Jeb Bush, challenged the constitutionality of the ban, which plaintiffs said barred an estimated 600,000 people from voting. They argued that the prohibition dating back to 1868 was used to prevent newly enfranchised blacks from voting during the Reconstruction and Jim Crow era.
A federal class-action lawsuit against then-Gov. Jeb Bush, challenged the constitutionality of the ban, which plaintiffs said barred an estimated 600,000 people from voting. They argued that the prohibition dating back to 1868 was used to prevent newly enfranchised blacks from voting during the Reconstruction and Jim Crow era. The state denied that argument, and the U.S. Supreme Court had declined to hear the case.
April 2007: Then-Republican Gov. Charlie Crist enacted clemency reforms that automatically restored voting rights to non-violent offenders. The new rules no longer required a hearing or petition, and the clemency board had 30 days to review and grant approvals. Crist (D), a U.S. Rep, wrote in an Orlando Sentinel op-ed last year that voting rights for 155,315 Floridians were restored in four years. An estimated 950,000 were disenfranchised.
March 2011: Scott unraveled the Crist-era clemency rules soon after taking office in 2011. He set a five-year minimum waiting period for nonviolent ex-felons and eight years for others. Those who were denied have to wait at least two years to re-apply.
Scott has only approved 3,008 applications since 2011, a spokesperson at the state’s Commission on Offender Review told Axios this week. Meanwhile, there's a backlog of more than 10,000 applications awaiting review.
January 2018: Organizers behind a November ballot measure announced that voters will decided whether to automatically restore voting rights for ex-felons, except for those convicted of murder or sex crimes. It needs at least 60% approval.
March 2018: A federal judge issued a scathing ruling that ordered the state to establish “robust and meaningful” new rules to determine when and how to restore ex-felons' voting rights. In February, the judge said the current "unconstitutional" process unfairly relies on the personal support of Scott.
April 2018: Facing a looming deadline, Scott called an emergency late-night meeting Wednesday with board members to consider new rules. But it got cancelled after the Atlanta-based 11th U.S. Circuit Court of Appeals sided with him and ruled he doesn't have to immediately overhaul the process. The suit to overturn the ban was filed in March of last year.
The big picture:
Felon voting rights restoration has the potential to shift the makeup of the country’s largest battleground, which plays a deciding role in presidential elections.
Observers said Democrats would largely benefit because the prohibition disproportionately affects African-Americans, a group that overwhelmingly votes Democratic. In Florida, per the Sentencing Project, more than 1 in 5 African-Americans are affected.
This story has been updated to reflect news developments. | {
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Living With the TekRMD
Adjusting to Usage
Adapting to Opportunities
It all started when...
By using the Tek RMD you can dramatically improve the way you live in your indoor space. To get the very best out of it though, you may need to think a little bit differently and potentially make some changes to your indoor environment.
One positive fact we can state right away is that the Tek RMD is both shorter and narrower than a wheelchair so that if you can navigate through your indoor environment with your existing wheelchair, you can certainly do that much more easily with the Tek RMD.
After some time you may find that you need to use your wheelchair much less indoors - you will be using your Tek RMD much more as it simply allows you to do more.
The issue we need to consider is how best to get on and off the device. You can transfer from your wheelchair to the Tek RMD but in order to do so, generally you will need to have a wheelchair with at least tilt-up foot rests and removable sides. If you have fixed foot rests its likely that you can't get the Tek RMD close enough.
Having visited lots of clients at home we have seen many scenarios that would actually make transfers from any device problematic. One of the really nice aspects of the Tek RMD is that transfers onto it can be a lot easier than transfers into a typical wheelchair. However, in order to make this a reality the current nature of your environment should be considered. Whether you are going to be using the Tek RMD at home or at an office it is recommended that a competent healthcare professional has recently undertaken an environment assessment of the premises. Are you clear about what types of situations you want to use the device in? Do you want to be able to transport the device? How will this be done?
To get onto the Tek RMD you are going to need to bring it to you, perhaps using the remote control, and the "tail" of the device needs to go under the surface, (perhaps a bed or chair)you are sitting on. This means that there must be sufficient clearance underneath. For example, if the chair you are on has a base that extends right to the floor this is going to be an issue because you wont be able to safely get your feet onto the device and the seat cushion in place because of this base keeping the Tek RMD too far away from you.
Also, if you try to transfer from a really soft surface you might have problems getting the cushion in place. When we visit people at home now to demonstrate the Tek RMD we will typically bring a slide sheet and a suitable chair so that lack of suitable equipment doesn't limit the demonstration.
Will you use the Tek RMD to transfer on/off the WC? If so we need to consider the transfer areas and turning circle that are available. Using the Tek RMD is is certainly possible to transfer on and off a combined wheeled/commode and shower chair - this can go over the WC and in and out of the chair. | {
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Hyde v Wrench
Hyde v Wrench [1840] EWHC Ch J90 is a leading English contract law case on the issue of counter-offers and their relation to initial offers. In it Lord Langdale ruled that any counter-offer cancels the original offer.
Facts
Wrench offered to sell his farm in Luddenham to Hyde for £1000, an offer which Hyde declined. On 6 June 1840 Wrench wrote to Hyde's agent offering to sell the farm for £1000, stating that it was the final offer and that he would not alter from it. Hyde offered £950 in his letter by 8 June, and after examining the offer Wrench refused to accept, and informed Hyde of this on 27 June. On the 29th Hyde agreed to buy the farm for £1000 without any additional agreement from Wrench, and after Wrench refused to sell the farm to him he sued for breach of contract.
Judgment
Lord Langdale's judgment read:
Under the circumstances stated in this bill, I think there exists no valid binding contract between the parties for the purchase of this property. The defendant offered to sell it for £1000, and if that had been at once unconditionally there would undoubtedly have been a perfect binding contract; instead of that, the plaintiff made an offer of his own, to purchase the property for £950, and he thereby rejected the offer previously made by the defendant. I think that it was not afterwards competent for him to revive the proposal of the defendant, by tendering an acceptance of it; and that, therefore, there exists no obligation of any sort between the parties.
See also
Stevenson, Jacques & Co v McLean [1880] 5 QBD 346
Butler Machine Tool Co Ltd v Ex-Cell-O Corp (England) Ltd [1977] EWCA Civ 9
References
Further reading
Category:English contract case law
Category:English agreement case law
Category:1840 in case law
Category:1840 in British law | {
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/* Soot - a J*va Optimization Framework
* Copyright (C) 1999 Patrick Lam, Patrick Pominville and Raja Vallee-Rai
*
* This library is free software; you can redistribute it and/or
* modify it under the terms of the GNU Lesser General Public
* License as published by the Free Software Foundation; either
* version 2.1 of the License, or (at your option) any later version.
*
* This library is distributed in the hope that it will be useful,
* but WITHOUT ANY WARRANTY; without even the implied warranty of
* MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the GNU
* Lesser General Public License for more details.
*
* You should have received a copy of the GNU Lesser General Public
* License along with this library; if not, write to the
* Free Software Foundation, Inc., 59 Temple Place - Suite 330,
* Boston, MA 02111-1307, USA.
*/
/*
* Modified by the Sable Research Group and others 1997-1999.
* See the 'credits' file distributed with Soot for the complete list of
* contributors. (Soot is distributed at http://www.sable.mcgill.ca/soot)
*/
package soot.baf;
import soot.*;
public interface PrimitiveCastInst extends Inst
{
public Type getFromType();
public void setFromType(Type t);
public Type getToType();
public void setToType(Type t);
}
| {
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Lame Pun Coon
he who is on multiple covers of time magazine
has issues | {
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A foreign company supplies and installs a machine in Switzerland. According to past practices of the Swiss Federal Tax Administration (SFTA), this process undeniably qualified as a work contract for supply. | {
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A cDNA encoding a chitinase from the epithelial cell line of chironomus tentans (Insecta, diptera) and its functional expression.
A cDNA coding for chitinase was isolated from Chironomus cells, which possesses conserved regions I and II characteristic for family 18 chitinases, a C-terminus enriched in Glu and Pro without the typical "PEST-region," putative glycosylation sites, a reduced number of C-terminal cysteines, and no typical chitin binding domain. Northern blots revealed one specific signal with an apparent size of 2.3 kb. The cDNA was expressed in the baculovirus/Spodoptera system as a His-tag fusion protein, which was secreted as a functionally active enzyme into the medium and could be separated from endogenous viral and Spodoptera-specific chitinases. | {
"pile_set_name": "PubMed Abstracts"
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SipA, SopA, SopB, SopD and SopE2 effector proteins of Salmonella enterica serovar Typhimurium are synthesized at late stages of infection in mice.
Salmonella pathogenicity island (SPI)-1 is essential for invasion of non-phagocytic cells, whereas SPI-2 is required for intracellular survival and proliferation in phagocytes. Some SPI-1 effectors, however, are induced upon invasion of both phagocytic and non-phagocytic cells, suggesting that they may also be required post-invasion. In the present work, the presence was analysed of SipA, SopA, SopB, SopD and SopE2 effector proteins of Salmonella enterica serovar Typhimurium in vitro and in vivo during murine salmonellosis. Tagged (3xFLAG) strains of S. enterica serovar Typhimurium were inoculated intraperitoneally or intragastrically to BALB/c mice and recovered from the spleen and mesenteric lymph nodes of moribund mice. Tagged proteins were detected by SDS-PAGE and immunoblotting with anti-FLAG antibodies. In vitro experiments showed that SPI-1 effector proteins SipA, SopA, SopB, SopD and SopE2 were secreted under SPI-1 conditions. Interestingly, it was found that S. enterica serovar Typhimurium continued to synthesize SipA, SopB, SopD and SopE2 in colonized organs for several days, regardless of the route of inoculation. Together, these results indicate that SPI-1 effector proteins may participate in the late stages of Salmonella infection in mice. | {
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36 So.3d 98 (2010)
MEANS
v.
STATE.
No. 2D09-5833.
District Court of Appeal of Florida, Second District.
May 12, 2010.
Decision Without Published Opinion Belated Appeal dismissed.
| {
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/*
* Copyright 2018 Karl Dahlgren
*
* Licensed under the Apache License, Version 2.0 (the "License");
* you may not use this file except in compliance with the License.
* You may obtain a copy of the License at
*
* http://www.apache.org/licenses/LICENSE-2.0
*
* Unless required by applicable law or agreed to in writing, software
* distributed under the License is distributed on an "AS IS" BASIS,
* WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
* See the License for the specific language governing permissions and
* limitations under the License.
*/
package com.castlemock.web.mock.soap.mode;
import com.castlemock.core.basis.model.ServiceProcessor;
import com.castlemock.core.mock.soap.service.project.input.ImportSoapProjectInput;
import com.castlemock.web.basis.manager.UrlManager;
import com.google.common.base.Strings;
import org.slf4j.LoggerFactory;
import org.slf4j.Logger;
import org.springframework.beans.factory.annotation.Autowired;
import org.springframework.beans.factory.annotation.Value;
import org.springframework.stereotype.Component;
import javax.annotation.PostConstruct;
import java.util.Optional;
@Component
public class SoapDemoModeInitializer {
@Value("${server.mode.demo.project.soap.url:}")
protected String projectUrl;
@Autowired
protected UrlManager urlManager;
@Autowired
private ServiceProcessor serviceProcessor;
private static final Logger LOGGER = LoggerFactory.getLogger(SoapDemoModeInitializer.class);
@PostConstruct
private void setup(){
if(!Strings.isNullOrEmpty(projectUrl)){
try {
final Optional<String> project = this.urlManager.readFromUrl(projectUrl);
project.ifPresent(raw -> serviceProcessor.process(ImportSoapProjectInput.builder()
.projectRaw(raw)
.build()));
} catch (Exception e){
LOGGER.warn("Unable to load the demo project", e);
}
}
}
}
| {
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Highly superb strands of wire
Here you will find how an artist makes intricate tree sculptures by twisting single hairs of wire. The concept is pretty fascinating and you will require having a deep take a look at the image gallery to comprehend how the art work is in fact made. In recent time this link has gone quite popular on the internet and you will need to have a look at each and every corner if you want to taste the ambiance. This is not something which you will stumble upon frequently on the internet and you should share it with your buddies . Inspect it now.
So search for wire sculpture tree today. If you’re exploring for wire tree sculpture, you have stay on the right post page. | {
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April 8, 2010
Apple today previewed its iPhone OS 4 software and released a beta version of the software to iPhone Developer Program members. The iPhone OS 4 beta release includes an updated Software Development Kit (SDK) with over 1,500 new Application Programming Interfaces (APIs) and over 100 new features that will be available to iPhone and iPod touch users this summer. New features include Multitasking for third party apps; Folders to better organize and access apps; improved Mail with a unified inbox, fast inbox switching and threaded messages; enhanced Enterprise support with even better data protection, mobile device management, wireless app distribution and more; Apple’s new iAd mobile advertising platform; and iBooks, the new ebook reader and online bookstore recently debuted on the iPad.Read More
That's it from Apple's presentation. We will be doing detailed coverage of iPhone OS 4 later today. Check it out on TechzTalk.
A: If you want to kill an app... you don't have to. We architected something so the user doesn't have to be the custodian of applications. We'll give the apps in the foreground as needed. The user doesn't have to worry about that at all. The user just uses things. In multitasking, if you see a task manager, they you blew it. Users shouldn't have to ever, ever, ever think about that stuff.
Q: How do you close applications? And can people use stuff other than iAd and Game Center?
A: iPhone 3GS has been a huge hit, and iPod touch sales have also accelerated last year. So a lot of these products, the install base, are the most recent products. The old ones will still live the new features, but they'll just miss ones like multitasking. If that's an incentive to get people to upgrade to the new phone, that's fantastic.
Q: Are you concerned at all about multitasking and other features that wouldn't work for the older devices. Will this OS upgrade be enough to get people to upgrade their phones and renew their contracts.
A:Steve says we can enhance the App Store any time as its a sever side program, it doesn't depend of iPhone OS releases. We are working constantly to improve discoverability via features like Genius.
Q:How are you going to improve App Store for discoverability?
A:Even though we've been using these internally for sometime, you still have butterflies in your stomach the few weeks before launch. You never really know until you get it into customers hands, and they tell you what they think. The feedback we've got has been off the charts. We think this is a profound gamechanger. We think when people look back some number of years from now, they'll see this as a major event in personal computation. What's been really great for me is how quickly people I've never talked to before just telling me how much this product is... How much they think this product is going to change their life and what they do. People are getting it very quickly. Says Steve.
Q: Anything surprises you about the initial reaction to the iPad so far?
A: There is a porn store for Android to go to. You can download them, your kids can download them. That's a place we don't want to go. We're not going to go there.
Q: Are there any plans for you to run unsigned applications, like on Android?
Steve says multitasking was depended on hardware and that was the only limiting factor.
Steve is talking about iAd for iPhone platform and how it is much better than ads on the desktops. today.
A: Everything is possible.
Q: So widgets are possible on iPad?
A: We just shipped it on Saturday. And then we rested on Sunday.
Q: Why have you veered away from widgets on the iPad?
A: We think it works better with the push notifications as it's in place now. The fast-app switching is very complicated and more impressive than what we demoed.
Q: It there a reason why you won't be able to see a timeline in Twitter or an IM conversation in the background?
A: This isn't necessary. They're all HTML5 ads and people can choose any tools they want. As long as it's HTML5.
Q: Will Apple provide platform for ad development?
A: No
Q: Is there going to be any change in Apple's position on Java and Flash in iPhone OS 4?
A: I think there will be some boundaries, like you can’t run any ad on ABC. There are some ads we’d rather not run, but the concept are that these advertisers will pay to run ads, and they’ll pay to run ads that are well received by the audience. I’m not sure there’s going to be anything but a light touch.
Q: Will Apple have approval process for ads?
A: The problem was there are a bunch of different social networks out there. So the goal was to build it into the platform, and everyone can be on the same gaming platform. We expect developers will build this into their games because they’ll have a wider audience.
Q: Will social gaming network supplant all the social gaming networks already available? and what will Apple do different?
A: No. It'll still be near the end of April.
Q: Will hugh ipad demand impact international launch?
A:I dont think it uses that much data.
Q: About Pandora?
A: I'm not sure that's a correct assumption.
Q: Multitasking will increase data usage, How will AT&T handle it?
Steve Jobs, Phil Schiller and Scott Forstall are on stage for Q&A.
This is for the presentation. Apple will have Q&A section after a short break.
iPad will get it in Fall. The iPhone OS 4 will be available for iPhone 3G and 2nd gen touch but some features like multitasking won't work on those devices.
Steve is now naming each of the seven new features that were shown just now. He says there are over 100 new features for users.
The ads can have content like video, games, images and even downloads. He is now showing NikeiD ad where you can design your own shoe. And now Target ad. The ads are very interactive and fun. I never thought I would say such a thing about Ads.
He is demoing a news app with Toy Story 2 ad. When you click on the ad it loads within the app and lets you interact with the content in the ad.
Main features of iAd are Emotion + Interactivity, Ads keep you in your app, built into iPhone OS, Apple sells and hosts the ads and 60 percent revenue goes to developers.
Steve says iAd is about both interaction and emotion. It's about motion plus interactivity. The ads keep you in your app. Today when you click on a banner ad, it yanks you out of your app and throws you onto the advertisers web page. So people don't click on the ads.
Steve is showing interaction vs emotion graphic, and say most ads today are either interactive or emotion and they are not good at both.
He says average user spend 30 mins everyday using apps and if they view ad every 3 minute it's 10 ads per device per day. Which is 1 billion ad impression per day.
The seventh feature of iPhone OS is iAd. Steve says "We have a lot of free or reasonably priced apps... we like that, but our devs have to find ways to make money. So our devs are putting ads into apps, and for lack of a better way to say it, we think most of this kind of advertising sucks."
The sixth feature of iPhone OS 4 is Game Center. it will offer developers APIs for features like Social gaming network, Invite friends, Matchmaking, Leaderboards and achievements. In short Xbox Live for iPhone.
Fourth feature is iBooks on iPhone. The app is very similar to iPad and Steve says "We think customers will really enjoy this."
The third feature is enhanced Mail app. It now offer unified inbox, multiple exchange accounts, fast inbox switching, threaded messages and open attachments with third party apps.
user can have as many Folders as he wants and can keep them anywhere. Folders will now allow users to keep up to 2,160 apps.
The second new feature on the iPhone OS is called "Folder". Steve says "I want to make a folder with games in it. I have several games, so I just push my finger on an app, they start to jiggle, and I just drag one app on top of another and it instantly makes a folder. It also automatically names the folder based on the categories of these apps, or I can rename."
The last two multitasking APIs are Task completion and Fast app switching. Some application like photo uploading takes time uses can switch application will the photo uploads and the Task completion and Fast app switching will take care of rest.
Next he talks about Push notifications and says that Apple has served over 10 billion notifications in past 9 months.
Scott says that GPS uses fair bit of power which is ok for turn by turn navigation apps, but for location aware social networking apps Apple uses cell towers that are always connected.
The third multitasking API is background location that can be used by applications like TomTom for turn by turn navigation.
Scott is back on stage
He says Until today navigation away from the app meant that I would go offline. Now I go into the background, but I can still receive calls. he shows few screen shots of Skype working in background.
David Ponsford from Skype is on stage to demo VOIP background API for their application.
Pandora uses background audio API one of the seven multitasking APIs. Now Scott is talking about VOIP background API.
Pandora team is on stage and demoing multitasking for the app. Pandora can now be controlled from lock screen.
Scott says Apple developed seven multitasking services as APIs and developers can access them depending on type of application. he is showing and example using Pandora.
Scott Forstall is on stage to explain how Apple did this while preserving battery life and performance..
The UI puts all the apps that are running at the bottom of the screen like a Dock and you can access all the running apps by double clicking the home button.
Demo Time: "I'm gonna launch mail, this has a URL - so I jump to safari - so I want to go back to mail... I double click the home button and a window raises that shows me all the apps that are running."
Steve says that Apple figured out how to implement multitasking without performance loss and uses a great UI to accomplish that.
Apple is going to talk about 7 new features and the first one is Multitasking
So today we are giving a developers preview of iPhone OS 4. It has over 1500 new APIs, 100 new user features and framework for hardware accelerated math functions.
Steve says "Now let's get to the iPhone." He says iPhone has won JD Power award three years in a row, has 64percent mobile browser user share, over 50 million iPhone sold and total of 85 million iPhone and iPod touch sold.
Steve is showing off apps specifically designed for iPad like Marvel, ABC, Epicurious and MLB.
We will be doing live coverage of the iPhone OS 4 event that will be held on April 8th at 10 AM PST/ 1PM EST / 6PM London. Apple sent out invitations for the event yesterday, which will be held on Apple’s campus in Cupertino CA. Join us here on April 8th for live coverage on live.techztalk.com. Bookmark the link.
Australian Macworld is reporting that Apple will be updating their MacBook Pro lineup next Tuesday, April 13th. The website received a tip from person familiar with Apple product cycles and inventory levels. The Macworld wrote:“The source said that an update to every MacBook Pro model was expected on Tuesday, 13 April, but was unsure about the MacBook Air.”Read More
April 7, 2010
At the iPhone OS 4 event on Thursday, Apple will show the next generation of iPhone OS, which would include direct printing support, multitasking for third party apps, API for new iAd mobile advertising service and better support for game development.Read More
April 6, 2010
Verizon’s CEO Ivan Seidenberg said before Council of Foreign Relations that the company has told Apple it wants to carry the iPhone. He further added he has no information if Apple is working on such a device now. He decline to comment if and when the popular smartphone will be available for Verizon customers.Read More
AnandTech ran comparative benchmarks on iPad, iPhone 3GS and Nexus One to see how Apple’s new A4 SoC stacks up against the Samsung chip in iPhone and Qualcomm Snapdragon QSD8250 chip in Nexus One. The Snapdragon will also be used in many tablets coming later this year, so this comparison should give an idea of what we can expect performance-wise from those tablets. AnandTech ran two tests, in the first test they recorded load time for various websites and in the second test they used WebKit SunSpider JavaScript Benchmark tool.Read More
For Apple, iPad was yet another successful product launch, as the device sold more than 300,000 units in first 15 hours. This prompted HP to release video of their upcoming iPad like tablet called HP Slate. The video highlights features of Slate that are missing from the iPad, like webcam, USB port and SD card slot. HP shows Skype running on the tablet, a photo gallery application, iTunes, multitouch and video recording.Read More
April 5, 2010
Just two days after iPad launch, Apple today sent out invitations to media outlets for an iPhone OS 4 event that will be held on April 8th. The invitation shows the shadow of number ‘4’ and says “Get a sneak peek into the future of iPhone OS.” No other information is provided on the invitation about the event.It is rumored that iPhone OS 4 will bring multitasking for third party apps, better notification system and unified mailbox. We should find out more on April 8th. We will be doing live coverage of the iPhone OS 4 event. Please join us on April 8th at 10 AM PST/ 1 PM EST on live.techztalk.com.
Apple today announced that it sold over 300,000 iPads in the US as of midnight Saturday, April 3. These sales included deliveries of pre-ordered iPads to customers, deliveries to channel partners and sales at Apple Retail Stores. Apple also announced that iPad users downloaded over one million apps from Apple’s App Store and over 250,000 ebooks from its iBookstore during the first day.Read More
April 4, 2010
BGR is reporting that iPad OS has some interesting references to upcoming Apple productions. The devices section in the filesystem shows new model references including iPhone3,2, iPhone3,3, iPod4,1 and iProd2,1. The current model number for iPhone 3GS is 3,1, for iPod touch is 3,1 and for iPad (aka iProd) is 1,1.Read More | {
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Castillo Perelada Rosado Cava
£10.99
A favourite of Salvador Dali, bursting with red fruit and vibrant in colour, this is an elegant Cava Rosado. This Cava was also used at the recent wedding of the new King of Spain. Pretty good credentials if you ask me! | {
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Q:
Paradigmatic vs syntagmatic relationship
I was exploring some various aspects of corpus linguistics and studying different approaches to corpus research on the internet when I came across these phinomena of paradigmatic
and syntagmatic relations. Can I get a satisfactory elucidation of both the concepts as well as how do the two technically and practically differ?
A:
Paradigmatics
Paradigmatic relations are relations of opposition and functional identity of linguistic elements (“OR - OR”), i.e. the paradigm combines sets of linguistic units that are similar according to one, and opposed according to some other criterion(s). Paradigmatics determines to which level of grammatical categoric hierarchy this or that language unit belongs, by analogy with units similar to it. For example:
Phonemes b, ɪ, g, s, t are the building blocks of morphemes big and -est.
Morphemes big and -est can combine to form the lexeme biggest.
The lexeme biggest is a part of the sentence That's the biggest fish I've ever seen!
Syntagmatics
Syntagmatic relations can be defined as relations of compatibility of elements of the level in a sequence of speech events, i.e. combination of phonemes with phonemes, morphemes with morphemes, etc. Syntagmatics combines language units by their direct combination.
The logical formula of syntagmatic relations is the formula "AND - AND", i.e. both one element and another element together, side by side, one after another, forming a chain of the same-order elements of a certain length.
Examples of syntagmatic relationships:
b=ɪ=g=ɪ=s=t, bɪg=ɪst (phonetico-phonological level)
big=est, water=s, walk=ing (morphological level)
teach=er, re=name (word-building sub-level)
tall man, tall tree (lexical level)
The tree is tall. (syntactical level)
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Pages
Ra Ranunkel, chairman of the cooperation council in Vollsmose, sounds the alarm and warns of an ethnic conflict in the crime-ridden district of Odense.
"It started to get violent about a month ago," says the chairman, who for years has defended Vollsmose's reputation."I always said that I'm proud to live in Vollsmose. I'm starting to get tired of it now. More and more of my neighbors come and say they're being attacked and robbed of their money. Or that their car was burned down. And all ask: 'Ra, can't you do anything?'. I have to admit, I feel powerless."
Ra Ranunkel says that there's a hardcore gang of Somalis who commit attacks that are deliberately directed at Danes. And it's primarily the Palestinians who burn the Danes' cars and control Bøgetorvet (Bøge square).
He thinks that the attacks are directed at Danes as a response to 'the Danish group of DPP-ers and racists' that in the past 5-6 years have been loudly voicing their views.
"You noticed that something was brewing, and now the Somalis and Palestinians are striking again."
An ethnic conflict, a racial conflict, is breaking out, and it's scary, says Ra Ranunkel, who before today's conference on Vollsmose's problems also sharply criticizes the Odense municipality's preventing efforts against youth gang-crime, which he calls 'totally ridiculous'. Fire them all and start from the beginning, he says. | {
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"fecal body odor" - my story and cure
I suffered from what this community calls "fecal Body Odor " from the age of 15-18/19. I actually think I found this message board all those years ago. I'm now 26 and 100% cured and never once have had a reoccurrence. I remember how my life was back then and how it is now and it is a complete turn around. When I finally figured out what my problem was and got to a place where I could sit in a room and have a normal conversation, be treated like a normal person, I literally cried of happiness.
Story:
Around 15 years old, I started to get comments about odor. I wasn't sure if it was caused by me at first, but then after I kept hearing the comments, I became aware that it was me. Strangely enough, I couldn't smell it myself.
As you can imagine or have experienced, the mental torment is almost unbearable. As a kid in high school, I was frequently in close proximity of a group of kids. After about a year of suffering through this, I became well known as "the kid who smells like shit". I had a small group of friends, who never really commented on it, but the signs were there - opening windows in winter, keeping a distance, etc.
Since I couldn't prove it myself, I pleaded with my parents to go to the doctor. It wasn't till I was older that we actually started going to the doctor, and even then I think they didn't believe me. So I was stuck with it. After reading through a couple of these posts, I see all the same patterns. OCD about cleanliness, charcoal, strange rituals, enemas, colognes/perfumes, etc. I even remember trying to use bleach to clean myself. Dumb idea.
I nearly always had a little bit of gas. Since I was afraid of the smell getting worse, I would hold it in and go to the bathroom to release whenever I could. I would never have any stains or actual shit/liquid, so I was perplexed as to what was happening to me. When I started going to the doctor, I got all sorts of random diagnoses - even one doctor said it might just be me growing up. What the f*** does that even mean?????
I remember one especially humiliating day in my life, my Science teacher called a random seat reassignment. Everyone got up, and she called kids to their seats one by one. I started getting worried it was about me. When I was one of the last 5 or so kids, I got so ashamed my face turned beet red. To make it even more humiliating for me, she left one seat open in front of me, one seat open behind me and then put the class trouble maker in the very last seat. A kid in the class asked why they changed seats, The teacher didn't answer. One of the kids said "It's because x smells like shit". It was agonizing. Since it had been a while suffering through this, and being publicly humiliated was a common occurrence at that point, I felt like I needed to escape. I went home and was ready to kill myself. I went to the bathroom, filled up the tub, and got in with the knife. I sat there for hours. I couldn't do it.
The most tormenting part of this period of my life was the psychological torture. Since I couldn't smell it myself, I began to try to confirm or disprove with friends and only the closest of friends. All I wanted was to know. When I was working with a good friend of mine, at the end of the shift, he openly said "Dude, you smell like ass." He told me about it and how everyone knew. He said it wasn't all the time, and sometimes it was much worse and sometimes it was just a little bit. I finally had someone be upfront with me about it after over a year of dealing with the issue.
My symptoms:
Odor - described as "shit", "farts", or "it stinks in here"
Inability to detect own odor
Gas/Bloating
Foul smelling stool
A weird bubbling in my lower right gut after eating
Constipation
My (self found) cure:
At the end of it all, no doctor was able to help. I tried all sorts of diets, but it was one in particular that cured me. For 6 weeks straight, I ate nothing but boiled chicken breast, white rice with no seasoning, egg whites, and green pea pods (low in fructose). My symptoms slowly decayed until they were completely gone. I started reincorporating things into my diet, and noticed them come back. Through the process of elimination, I had nailed it down to gluten. two years of suffering - all because of gluten. After completely eliminating gluten from my diet, I was cured. This is much more difficult than it appears, and it can't be half-assed. If you want to be free of this - it has to be 100% adherence without any slip ups. I'm sure if you went through what I had to go through, you won't have trouble finding the motivation to do this.
My life is on the right track. I moved as soon as I could, and began a new life. I graduated near the top of my class, and I'm now working in NYC at a top consulting firm. This wouldn't have been possible with the debilitating and strange disorder I had when I was younger. I don't think I would be alive today had I been suffering this long.
Please, if you have not tried it, and the above story/symptoms sound familiar to you, you need to try a 100% strict gluten-free diet. I would also suggest following the "zero-chance" diet I followed above to maximize your body's ability to heal.
I felt the need to share my story and my cure. I don't expect it to be the cure all for all of you, but I know for a fact it will be the way for some of you. Good luck. | {
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Removal of bone staples: a potential problem in revision surgery after ligament reconstruction.
Two cases are presented in which an attempt to remove the staples used to fix an artificial ligament caused the front of the tibia to break. A mechanical study was performed to measure the force required to extract staples from bone cement, as well as from calf bone with predrilled holes. Using an extraction tool, it was possible to generate an average maximum force of 500 N by hand. At that load, all staples remained firmly anchored in cement and bone. The staples were impossible to remove even when the serrations in the staple legs were reduced by 75%. Accordingly, special care is necessary to avoid complications with staple removal. | {
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We all remember the well known fable told by the ancient Greek slave and storyteller, Aesop, about the shepherd boy drafted to keep watch over a flock of sheep, and who, out of boredom, decided it would be great fun to fool the nearby villagers by pretending that a wolf was attacking the sheep. After the villagers rushed out to save the sheep a number of times based upon the boys fabrications they refused to believe him when the wolf actually did show up and began to consume the sheep. The obvious declared moral of the story is generally expressed as “There is no believing a liar, even when he is telling the truth.” However, there is, I submit, a second, unstated moral to the story as well. In spite of the shepherd boys prevarications the wolf was real. And the wolf did, in the end, show up to devour the poor sheep.
All of which, however, raises an interesting question. Why are so many people so fearful of and ready to believe in an impending doomsday?
Which brings us to the point of this article. For centuries various predictions have been made about the end of the world on certain dates by assorted means and on quite a number of occasions these predictions have been believed by a significant number of people. Obviously the world did not perish in late December of 2012, the most recent date proffered in a long tradition of doomsday predictions that failed to materialize.
My first encounter with such notions came about in the late 1960s while still in high school. I had a poster on my bedroom wall entitled ‘Goodbye California’ and it showed the entire state of California breaking off from the North American mainland and sinking into the Pacific ocean, an occurrence which was widely believed to be impending by a considerable number of folks back then. A few years later, in 1973, with the approach of Comet Kahoutek, apocalyptic predictions were proliferating, causing fairly widespread consternation among the astronomically challenged. I next recall the date of November, 1978 being foretold as a time of extensive global disasters.
Asteroid 2012 DA14 is a cosmic reminder that catastrophes, in spite of all the over-hyped, pseudo-scientific predictions, are indeed real.
Then came the early 1980s and more predictions about a series of escalating disasters brought about by planetary alignments. The eruption of Mt. St. Helens in May of 1980 was interpreted as being the opening act of this apocalyptic succession. The culminating date was usually given as March, 1982, when all hell was going to break loose. When that date passed without incident others claimed that December 31, 1988 was actually the date. Of course that date came and went as well. Then there were the prophecies of Nostradamus, which foresaw July of 1999 as the arrival date for the ‘King of Terrors,’ inciting widespread fear among believers of a looming apocalypse. Only a year later came the turn of the Millennium and fears of a planetary pole shift in May of 2000 that was going to wipe out civilization. One book from the early 1980s which made this prediction went through multiple reprints up to the year 2000, but, needless to say, has not been reprinted since.
Not to mention Y2K, which was, perhaps, somewhat plausible. (We can’t discount the fact that governments did spend over 100 billion dollars to secure computers against failure, which may have been partially responsible for averting the expected breakdown.) And finally we have the Mayan Apocalypse which even spawned a silly movie. (With awesome special effects though). These are only a few of the failed predictions of which I am aware that have occurred in my lifetime and that of many readers of this article. There have been countless dozens of other such failed predictions stretching back through the centuries.
I think we could say that the batting average of those prognosticators of world destruction has so far been about zero. All of which, however, raises an interesting question. Why are so many people so fearful of and ready to believe in an impending doomsday? I think the answer to that question brings us to the unstated moral of Aesops fable. In spite of all the false alarms the wolf turned out to be very real.
And eventually the wolf showed up.
If instead of trying to foresee the future of planet Earth we look to its past, we are confronted with a rather disquieting mass of evidence about the actual history of global change. While the prevailing paradigm for most of the 20th century was one of slow, gradualistic change, that interpretation has given way to a new model which recognizes that profoundly dynamic changes have occurred on a scale unprecedented in recent times. Every month now brings new scientific revelations about Earths cataclysmic history. Over the last 3 or 4 decades scientists from multiple disciplines have steadily documented the reality of great catastrophes in the history of the Earth. We now know that Earth has been subject to devastating asteroid and comet impacts too numerous to count. We know that gigantic volcanic eruptions have occurred sufficient to cause the sky to go dark for months at a time. We know that great tsunamis have repeatedly occurred that would make the Japanese and Indonesian disasters look trivial. We know that vast ice ages have gripped the planet over and over again. We know that mega scale floods that can only be described as biblical in scale have devastated large regions of the Earth’s surface. And we suspect that the majority of Earth’s extinct animal species succumbed to global disasters. And finally, we now know that numerous cataclysmic episodes have occurred during the several hundred millennia that we humans have been present on Earth.
Is it possible that racial memories of past tribulations suffered by the human species fuels the fear of future doomsdays? And given what we know about the frequency of past global disasters would it not be prudent to assume that at some future date we will again be faced with apocalyptic events? Recognition of Earth’s catastrophic history does not imply a fatalistic view of life. Rather it provides a dose of reality and a higher perspective on the human condition than is generally acknowledged by the occupants of the institutions of social power.
Recognition of Earth’s catastrophic history does not imply a fatalistic view of life. Rather it provides a dose of reality and a higher perspective on the human condition than is generally acknowledged by the occupants of the institutions of social power.
Professor of zoology and human ecology Kenneth E. F. Watt, wrote in his 1974 book The Titanic Effect that “The magnitude of disasters decreases to the extent that people believe that they are possible, and plan to prevent them, and to minimize their effects.” Thanks to early warning systems in place in the Pacific Ocean, which were lacking in the Indian Ocean, the great Japanese tsunami of 2011 caused about 20,000 deaths whereas the death toll of the Indonesian tsunami of 2004 was on the order of 300,000.
As if to underscore the point of this article, on February 15 came a close brush with disaster.
Asteroid 2012 DA14 will whiz by the Earth at a distance of only 17,000 miles, inside the orbits of many satellites. It is about the same size as the object which exploded over Siberia in 1908. Had it collided with Earth the resulting detonation would have been equivalent to that of the largest hydrogen bombs, enough to completely obliterate a metropolitan area the size of Atlanta.
Asteroid 2012 DA14 is a cosmic reminder that catastrophes, in spite of all the over-hyped, pseudo-scientific predictions, are indeed real.
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Author: Randall Carlson
Randall Carlson is a master builder and architectural designer, teacher, geometrician, geomythologist, geological explorer and renegade scholar. He has 4 decades of study, research and exploration Into the interface between ancient mysteries and modern science, has been an active Freemason for 30 years and is Past Master of one of the oldest and largest Masonic lodges in Georgia. He has been recognized by The National Science Teachers Association for his commitment to Science education for young people.
His work incorporates Ancient Mythology, Astronomy, Earth Science, Paleontology, Symbolism, Sacred Geometry and Architecture, Geomancy, and other arcane and scientific traditions. For over 25 years he has presented classes, lectures, and multimedia programs synthesizing this information for students of the Mysteries.
It is his aspiration to affect a revival of lost knowledge towards the goal of creating the new world based upon universal principles of harmony, freedom, and spiritual evolution.
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I don’t really get all the hate and whining from some people about Javascript. I love Javascript. It won’t run everything or solve every problem but it is the closest we have come to “run everywhere” — please do NOT mention java.
With JavaScript, you can write applications that work:
in your browser (pretty much ALL of them) on your phone and tablet (e.g. React Native, Cordova) on your desktop (e.g. electron runs on mac, linux and windows) on your server i.e. node and even in your database e.g. mongo db
You don’t need to download a 4 gigabyte IDE to create a hello world, you don’t need to wait 30 seconds to compile and run your app, all you need is a text editor.
Sure javascript has flaws but so does every other language out there but nothing comes close — not even by a mile — to the reach and flexibility of javascript.
I love the innovation (and explosion) of javascript tools, frameworks and libraries. I know it can get tiring but it’s fun and guess what, you don’t have to learn ALL of them.
With that said, can we please stop creating “languages” on top of javascript and please stop using them in your projects. We already have enough: TypeScript, Elm, Coffeescript and others. I highly recommend you do NOT use any of them in your projects.
I will explain why but first let me say how much I appreciate the diversity in choices and most importantly how thankful I am to the people that create these awesome tools and “languages”.
I was a huge coffeescript fan. I decided to use it for a project a few years back and as the project grew I quickly realized that it was the worst decision I made and six months into the project we converted everything over to Javascript. Here are some reasons why that was a bad decision:
I had to setup another build step to “compile” it back to javascript — not a huge deal but it can be a pain some times. It was hard to debug since what you see in the browser is different than what you have in your coffeescript files — for the most part, it is very readable but you still have to perform a mental translation. The biggest problem by far is the learning curve for every new developer that joined the team — yet another thing they had to learn to ramp up Most code samples online were 99% in javascript The team started losing some of their javascript skills, slowly, javascript code started to look foreign and we wanted to see everything in coffeescript. We didn’t keep up with all the advancement in javascript e.g. ES6 — arrow functions, deconstruction and so on. We couldn’t just put a few lines of code directly in a script tag to test some stuff and if we did, we had to do it in javascript and later “translate” it back to coffeescript.
Although, I didn’t play much with TypeScript or Elm, I would assume they would have similar problems.
RE: TypeScript — really cool concept and I get some of the benefits but why are we forcing a dynamic language to “act” static? C# is jumping through hoops to act more dynamic and now we are jumping through hoops trying to make javascript act more static. WTF!!!
TL;DR | {
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Thus far, as a medical observation system for, when performing an operation of a minute part of the brain, the heart, etc. of a patient that is an object to be observed, observing the minute part, an optical microscope system including a magnification optical system that magnifies the minute part has been known (e.g. see Patent Literature 1). When performing an operation using the microscope system, an operator such as a medical doctor (the user) performs the operation while observing the surgical site via an eyepiece.
FIG. 10 is a diagram schematically showing a situation in which an operator performs an operation using a conventional optical microscope system. As shown in FIG. 10, an operator 401 performs an operation while observing the surgical site of a patient 402 via an eyepiece 502 of a microscope unit 501. Hence, when the operation time is increased, the burden on the eye of the operator 401 is increased, and also the burden on the body of the operator 401 due to maintaining the same posture is increased.
As a technology to solve such a problem of the optical microscope system, a video microscope system including an imaging means that images a minute part such as a surgical site is known (e.g. see Patent Literature 2). FIG. 11 is a diagram schematically showing a situation in which an operation is performed using a conventional video microscope system. As shown in FIG. 11, an operator 401 performs an operation while observing, with a monitor 602, an image of the surgical site of a patient 402 captured by an imaging unit 601. By such a video microscope system, the burden on the eye and body of the operator in a long-time operation can be greatly reduced as compared to the case of the optical microscope system. | {
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Methadone-induced respiratory depression in the neonatal guinea pig.
Respiratory depression, the most serious side-effect of opioid treatment, is well documented for morphine, the most commonly used opioid in neonatal care. Less is known about methadone, a clinically relevant opioid analgesic, especially during neonatal development. This study was undertaken to determine the neonatal respiratory effects of methadone. We hypothesize that methadone is equipotent to morphine, compared to our previous morphine results in the same animal model, but has a much longer duration of action, due to its longer elimination half-life. Neonatal guinea pigs (3-14 days old) randomly received a single subcutaneous dose of methadone or saline. Using a non-invasive plethysmographic method, we measured ventilatory and metabolic parameters before injection and at intervals for 32 hr after injection while pups breathed "room air" or 5% CO(2) gas mixtures. Methadone-induced depression of ventilation was most evident during 5% CO(2) challenge. The onset of drug effects was within 15 min for all ages and doses, but the duration of action decreased with age. While the depth of methadone-induced respiratory depression did not depend on pup age, the control of breathing was different in 3-day-old pups, where inspiratory time increased fourfold; twice that of older pups. We conclude that methadone induces a naloxone reversible respiratory depression in guinea pig neonates and, in the very young, causes an abnormal breathing pattern due to changes in respiratory timing. Methadone is more potent than morphine with respect to neonatal respiratory depression, but surprisingly, the duration of methadone action was not longer than morphine. | {
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Q:
Clicking a Link in td with Watir
I'm trying to click an image in with a Watir script. Here's the source code for what I'm trying to click:
<td align="right">
<a onclick="confirmAndSubmit('Exit application?', 'saveAndExit')"
onmouseover="style.cursor='hand'">
<img src="/images/exitBlue.gif" align="bottom"></img>
</a>
</td>
Watir seems to be unable to locate the element based on my code. It seems like I have to write sort of a complex statement with the arguments. I've tried
$b.td(:img, "src='/images/exitBlue.gif'").click
as well as
$b.element(:css, "td[onClick='confirmAndSubmit('Exit application?', 'saveAndExit')']").click
but nothing seems to locate the data in the table. Any suggestions on how to go about clicking this?
A:
I found the solution with a bit of trial and error. As mentioned in the comments, the image was inside nested tables. I targeted the div inside the first table and was able to get to it. The element.flash method was invaluable in troubleshooting. The code I was originally using was only getting inside the first cell of the table and therefore couldn't find the image. The code that worked for me:
$b.div(:id, "bar").table.td(:index => 1).image.click_no_wait
| {
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Forging is a process by which the shape and physical properties of metal can be changed. The process involves placing a piece of metal (normally heated) between the halves of a die and forcing the die to close by impact or pressure. The operation causes a controlled plastic deformation of the metal into the cavities of the die. This flow of material results not only in a change in shape of the metal but also increases the density and uniformity of the metal, improves its grain structure, and causes a shape-conforming grain flow. The resulting workpiece has properties which are superior to those generated by other methods, making forging essential where high performance workpieces are required.
One of the critical components of a forging system is the lubricant which separates the die from the workpiece. As with all lubricating situations, it is essential that this lubricant be effective to minimize wear of the extremely expensive forging dies and minimize expenditure of energy over a wide range and condition. Somewhat peculiar to the forging process, however, is that merely maximizing lubricity is not the only goal, since a certain degree of friction between the workpiece and die is essential to optimize the properties of the workpiece. This controlled lubricity is particularly important when it is necessary to fill deep impression dies.
As modern demand for safer and more dependable machine structures increases, the forging art is being applied to more difficult materials, at higher temperatures and pressures to form more complex shapes. Although oil-based lubricating compositions, which are effective under these extreme conditions, have been developed, their properties are found to conflict seriously with national commitments to personal safety and protection of the environment. The oil-based lubricants are normally flammable and can ignite well below common operating temperatures. Normal operation results in billowing carbonaceous smoke which is unpleasant and sometimes toxic. Furthermore, cleaning of the workpieces and dies requires solvent washes that produce large quantities of rinse which, because of the economics of recycling, and desire to protect the environment can present serious disposal problems.
Attempts at avoiding the problems inherent in the use of oil-based lubricants have generally been directed toward water-based compositions. Early attempts, involving mixtures of graphite, clay minerals, and molybdenum disulfide, were found ineffective, because they did not sufficiently wet the hot metal surfaces to provide lubrication. They were also unacceptable due to the corrosion caused by the high temperature break-up of the components. Additives and substitutions which solved one problem often created another. For example, the addition of soaps to improve wetting often caused caking in cavities and increased smoke production and odor. These and other difficulties experienced with the prior art devices have been obviated in a novel manner by the present invention.
It is, therefore, an outstanding object of the invention to provide a forging lubricant which effectively reduces the die wear and energy requirement of a forging operation.
Another object of this invention is the provision of a forging lubricant which produces an extremely low amount of air pollution.
A further object of the present invention is the provision of a forging lubricant which is simple and easy to produce and which, in use, leads to relatively less expense in overall operating costs.
It is another object of the instant invention to provide a forging lubricant which has a long storage life and is not adversely effected by reasonable storage conditions.
A still further object of the invention is the provision of a forging lubricant which is simple and safe to apply to the dies using spray equipment.
It is a further object of the invention to provide a forging lubricant which is virtually non-flamable and does not give off undesirable vapors or corrosive byproducts during use.
It is a still further object of the present invention to provide a forging lubricant which has the proper combination of lubricating properties to allow predictable and effective operation of forging technique over wide ranges of workpiece shape, temperature, pressure and material.
Another object of the invention is the provision of a forging lubricant which has adequate insulating properties to prevent undesirable cooling of the workpiece by the dies.
Another object of the invention is the provision of a forging lubricant which effectively prevents workpieces from sticking in the dies after the forging operation.
Another object of the invention is the provision of a forging lubricant which is easily cleaned from the workpiece and dies, and which results in a rinse which can be easily cleaned to avoid pollution.
With the foregoing and other objects in view, which will appear as the description proceeds, the invention resides in the combination and arrangement of steps and the details of the composition hereinafter described and claimed, it being understood that changes in the precise embodiment of the invention herein disclosed may be made within the scope of what is claimed without departing from the spirit of the invention. | {
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Effect of the Bone Morphogenetic Protein-2 Doses on the Osteogenic Potential of Human Multipotent Stromal Cells- Containing Tissue Engineered Constructs.
A strategy for improving the efficacy of stem cell-based bone tissue engineering (TE) constructs is to combine bone morphogenetic protein-2 (BMP-2) with multipotent stromal cells (MSC). Previous studies on the potential cooperative effect of BMP-2 with human multipotent stromal cells (hMSCs) on bone formation in vivo have, however, shown contradictory results likely due to the various and/or inappropriate BMP-2 doses. Our results provided evidence that the addition of BMP-2 at low dose only was beneficial to improve the osteogenic potential of hMSCs-containing TE constructs, whereas BMP-2 delivered at high dose overcame the advantage of combining this growth factor with hMSCs. This new knowledge will help in designing improved combination strategies for tissue regeneration with better clinical outcomes. | {
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Is Scott Pruitt plated in gold or spattered in mud?
In a week where President Trump’s lawyer got raided by the FBI, Trump’s top homeland security adviser resigned, the president agreed to join an international response to an act of chemical warfare believed to have been conducted by the Syrian government, and news broke that the speaker of the House would not seek re-election — all before breakfast on Wednesday– it’s easy to forget that we ended last week expecting the imminent ouster of Environmental Protection Agency Administrator Scott Pruitt.
Pruitt is still employed at the moment. But accusations that he received improper gifts from lobbyists, misspent public funds and engaged in questionable personnel practices have not gone away. And the swirl of scandal surrounding him — there are at least five open inquiries into Pruitt’s behavior, according to The Washington Post, and the Office of Government Ethics indicated Friday that it remains very interested in his alleged ethics violations— prompted a flurry of appraisals of his tenure at EPA. They were … confusing. He’s either a deregulatory master, praised by Trump and Republicans for his pro-business approach to environmental regulation and accused by liberals of destroying the environment. Or he’s just a spin master, and most of his accomplishments have been smoke and mirrors.
The truth, of course, is a matter of perspective, and it all depends whether you take the short, long or longer view.
Despite his reputation for effective and prolific deregulation, much of what Pruitt has done is to prevent the implementation of Obama-era policy by simply delaying those policies — not dismantling them. Consider, for example, the EPA’s own list of deregulatory actions that were completed under Pruitt’s tenure, which it compiled as part of documenting the agency’s adherence with Trump’s 2-for-1 deregulation executive order requiring that for each new regulation added to the books, two must be removed. There are 24 actions on this list, but only two actually represent the complete and successful negation of an Obama-era environmental policy. In one case, the EPA withdrew its request for oil and gas companies to complete a survey about their equipment and the tools they were using to reduce greenhouse gas emissions. In the other, the agency rolled back a decision to increase air-quality-monitoring requirements on facilities that store and treat certain kinds of hazardous waste. Of the remaining 22 actions, 10 were delays of Obama-era proposals — mostly extending deadlines for when rules would go into effect. One implemented a rule written during the George W. Bush administration that the Obama EPA had tried to block. Three offered exemptions for ozone pollution rules to a handful of counties in Tennessee and Louisiana. Two were uncontroversial updates of standards. One made a minor amendment to product-labeling laws. Five implemented rules that had originally been put forward under the Obama administration.
On the whole, Pruitt is getting less done than he would like you to believe. It’s not nothing. Those deregulatory actions made Pruitt’s EPA the most productive deregulator in the Trump administration, according to 2017 data compiled by the Office of Information and Regulatory Affairs. But as Pruitt has rushed to block as much as possible, the EPA has wound up issuing shorter, less detailed rulings that aren’t holding up well to legal challenges. Case in point: In May 2017, Pruitt issued a 90-day stay of an Obama-era regulation that sought to reduce methane emissions at landfills. But the stay was challenged in court and the EPA let the stay expire, allowing the regulation to take effect. As of now, the rule remains on the books, even as Pruitt’s EPA was sued by several states for failing to enforce it. It’s possible that his legacy could end up mimicking that of Reagan appointee Anne Gorsuch, who slashed the EPA’s budget and enforcement activities — then resigned under a cloud of ethics violations just 22 months into the job. Her work left little measurable impression on environmental quality.
But while it’s possible to draw an analogy between Pruitt and Gorsuch, Donald Trump is no Ronald Reagan. A big part of why Gorsuch was unable to build a lasting legacy is that she was replaced by William Ruckelshaus, the EPA’s founding administrator, who undid many of her efforts aimed at dismantling the agency. Environmental protection, however, was much more of a bipartisan issue back then, and if Pruitt leaves his post, his replacement will probably look a lot like, well, Pruitt. Hostility to more environmental regulations and skepticism about comprehensive government efforts to combat climate change are GOP orthodoxy now, not just the views of one rogue administrator.
Sure, the Senate would have to confirm anyone put forward as a replacement for Pruitt, and Republicans hold a very narrow majority in that chamber (51-49). But there’s no guarantee that Democrats would unanimously oppose an anti-environmental-regulation nominee. In fact, Democrats in coal country, like West Virginia Sen. Joe Manchin, might feel pressure to vote for someone like that, particularly in an election year. Manchin, who voted to confirm Pruitt, has already said that he’ll support Andrew Wheeler, a former coal lobbyist, for the role of EPA deputy administrator. And if even if Pruitt leaves and is not replaced quickly, it’s unlikely that the agency would go back to its more pro-regulation Obama-era approach, since some of Trump’s political appointees would likely remain at the EPA.
Remember when one-time chief strategist Steve Bannon left the White House? Bannon’s departure didn’t matter much in the end because the president himself adheres to nationalist/populist/conservative identity politics, so they remained an element of this policy-making even without Bannon there to push those views. This is even more true in Pruitt’s case. Essentially the entire Republican Party agrees with Pruitt on environmental policy, both inside and outside of the Trump administration. Trump agrees with him too.
If the president gets rid of Pruitt (and his ethics problems), Trump will still find ways to annoy liberals and delight conservatives on environmental policy. And maybe this time he’ll get an EPA administrator who does more than delay. In other words, it’s possible to say that Pruitt isn’t the deregulation powerhouse the president has portrayed him as (the short-term view) and that his resignation wouldn’t exactly spell relief for liberals (the long-term view).
Only from a still longer-term perspective is there truly good news for environmentalists. The very quirks of the EPA that allowed Pruitt to undo as much as he did may in turn undo his legacy. Congress delegates a great deal of authority to the EPA, which the agency uses to take broad laws — particularly the Clean Air Act and the Clean Water Act — and interpret them, creating the regulations that actually make the laws function. In the process, it decides how (or whether) those regulations will be enforced. That system gives the agency wide-reaching ability to determine the boundaries of its own mission and act without worrying about what Congress thinks. Unsurprisingly, therefore, Pruitt was not the first EPA administrator to be criticized for acting autocratically. His immediate predecessor, Gina McCarthy, faced similar accusations for her pro-regulation activity.
Pruitt’s path to undoing much of McCarthy’s legacy (and that of her boss, then-President Barack Obama) was relatively straightforward. All he had to do was decide that McCarthy had incorrectly interpreted the law, or decide not to implement proposals made under her tenure.
But this kind of power and autonomy can cut both ways. McCarthy learned that lesson when Pruitt moved EPA policy to the right. And Pruitt may learn it too — but probably not until someone else sits in the Oval Office. | {
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Effects of Messages Delivered by Mobile Phone on Increasing Compliance With Shoulder Exercises Among Patients With a Frozen Shoulder.
The aim of this study was to examine the effects of reminders, encouragement, and educational messages delivered by mobile phone on shoulder exercise compliance and improvements in shoulder function among patients with a frozen shoulder. A randomized controlled trial design was used. A convenience sample of patients with a frozen shoulder in an orthopedic outpatient clinic was recruited. All participants were instructed on how to do shoulder exercises and were provided with a printed pamphlet about shoulder exercises. Then, the intervention group received reminders, encouragement, and educational messages by mobile phone daily for the next 2 weeks, while the comparison group did not. The intervention group had higher compliance with shoulder exercises than did the comparison group (t = 2.263, p = .03) and had significant improvements in shoulder forward flexion (F = 12.067, p = .001), external rotation (F = 13.61, p = .001), and internal rotation (F = 5.903, p = .018) compared to those in the comparison group after the 2-week intervention. The text messages significantly increased patient compliance with shoulder exercises and thus improved patients' shoulder range of motion. Hospital or clinics can send appropriate messages to patients via text message platforms in order to remind and encourage them to do shoulder exercises. | {
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Monthly Archives: December 2013
FOOTBALL is a numbers game: the comfortable victory over Reading made it three wins on the spin, three clean sheets, nine points from nine, six points off the play-offs… they are great digits to wave goodbye to a traumatic 2013 that has been dominated by a long downward spiral of negative numbers that led to Mogga’s P45.
Boro now have 36 goals. Only the top two Derby and Leicester have scored more. Of course, scoring goals was never the problem. Even under Tony Mowbray Boro were rattling the goals in: threes, fours, a cluster of 2-2 draws. The problem was keeping them out and no matter what combination of players were used, goals were seeping through – especially from set-plays deep in the red zone. Being two goals up wasn’t a guarantee of a point.
But the ever open door that was Boro’s Achilles heel has slowly creaked shut under Aitor Karanka.
I’LL BE WITH YOU SOON. Got tomorrow’s spread to write. In the meantime, if someone wants to kick off with an appraisal of mighty Boro’s glorious defeat of table-topping Burnley and the impact of former frozen out flanker Emmanuel Ledesma, crack on….
But a few brief observations:
OH NO! Football’s Inevitability Drive is broken!Millwall away was a game that had “Scott McDonald late winner” written all over it. It was a dead cert daft quid magnet. So we are all out of pocket but who cares? Boro won and the ghost of Christmas past was far from scary.
OH NO! There goes the relegation cliche klaxon!
Jacob Butterfield has uttered the dreaded phrase: “We’re too good to go down.”
That will scare the hell out of a lot of battle scarred supporters – including a cocooned few who may not have even been too worried before those dread words were uttered.
It is part of the lexicon of the lower end of the league.
Everyone knows that once you start putting up that particular linguistic defence you are already deep in the sticky stuff. Supporters of all clubs know that phrase is one of the key indicators that a basement battle is OFFICIALLY on.
DID you hear a loud metallic thud rumbling from the Riverside at 4.40pm on Saturday? That was the sound of the peseta dropping for Aitor Karanka.
The defence – whichever permutation of mismatched miscreants is wearing the shirts – is just not good enough. As a unit they are deeply, fundamentally flawed.
They lack organsation, cohesion, focus, concentration, understanding, nous and leadership. And, no matter what any given week’s short straw media muggins says, they clearly lack the ability to “learn from their mistakes.”
It appears to be a mental weakness ingrained in the DNA of this squad. How else can you explain their repeated vulnerability to the most predictable of set play situations?
AS FOOTBALL united to salute the memory of Nelson Mandela, a champion of racial unity and mutual respect, Boro fans were dragged reluctantly into a divisive race row after an unsavoury Quran ripping incident by a small group in the away end at Birmingham.
The club have reiterated their own strong line on racism but more importantly so have Boro supporters who were quick to condemn the handful of idiots. Here by popular demand (no, really) is the Kick It Out remix of this week’s Big Picture column.
WELL that was a sickener. Birmingham got a late, late leveller to mug Boro of what would have been a hard earned – and rare – away win and kick long suffering supporters squarely in the kisser. You would think we would have evolved six inch thick emotional armour against the stoppage time sucker punch but it still stings like hell.
Leaking deep into added time to a twice taken corner was a real blow. Especially after also conceding a needless penalty. All we needed was a harsh sending off to complete the shambolic defending full set.. Battling Boro had played with a real shape, spirit and solidity and were within touching distance of a result that could have been a turning point of the season before the familiar fatal flaw showed its face. It hurts. But it isn’t a great surprise.
A LAST gasp sucker punch knocked the stuffing out of Boro at Pride Park.
The ten men had worked their nuts off to contain the Championship’s form side: “Steve McClaren’s Derby.” That Boro’s former boss engineered a painful 2-1 defeat for Boro with the goals coming in the Red Zones (45+1 and 90) was heavy with irony. | {
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42-letni nauczyciel z Jastrzębia-Zdroju twierdzi, że jest w związku z 17-letnią uczennicą. - To jest po prostu miłość - mówi "Dziennikowi Zachodniemu", któremu udało się porozmawiać z nauczycielem. - To jest prawda, że jestem w związku z dziewczyną, którą uczyłem. To jest nieetyczne, ale nie jest niezgodne z prawem - przekonuje.
REKLAMA
Mężczyzna miał poznać nastolatkę w hufcu, do którego należał od lat. Dziewczyna była harcerką. Od tamtego czasu regularnie się spotykali. Mężczyzna twierdzi, że tworzy z 17-latką związek, zostawił rodzinę, zamierza się rozwieść. 42-latek przekonuje też, że zamierza się zwolnić z pracy w szkole. Podobno zaniósł do dyrektorki wypowiedzenie umowy o pracę za porozumieniem stron.
Jest zawiadomienie do prokuratury
Na razie nauczyciel został zawieszony w obowiązkach. - Złożyłam w tej w sprawie wniosek do komisji dyscyplinarnej o wszczęcie postępowania wyjaśniającego oraz zawiadomiłam prokuraturę - mówi dyrektorka szkoły w Jastrzębiu.
Jak tłumaczy prokuratura z zawiadomienia wynika, iż jeden z nauczycieli miał obcować płciowo z jedną z uczennic powyżej lat 15, ale poniżej 18. - Śledztwo jest rozpatrywane w kierunku artykułu 199 paragrafu 3 Kodeksu Karnego, który dotyczy seksualnego nadużycia stosunku zależności – wyjaśnia prokurator.
Wiozła uczniów do szkoły, gdy autobus zaczął płonąć. Uratowała 20 dzieci | {
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Q:
Is there a way to keep Telegram bot running when closing Python?
I've built a very simple Telegram bot by following this tutorial. So I have a file containing Python code, and when I run that code, the bot will echo what I say.
Is it true that the bot will only work when I have Python on and the code running? Would this mean that I cannot run any other script in Python at the same time, and neither can close Python down if I want my bot to keep working?
Is there any way to get around this, so that the bot will always be 'on'?
A:
A Telegram bot is a Python program. When you run it, it do what it is supposed to do, then, if you stop the program, the bot stop to work. The problematic is common to all programs, particularily on a server. Think about Nginx, Apache, ssh, etc. Thay are all programs, and they all stop to do their job when they are closed.
If you want to make sure your bot will run always, you have to daemonize it. There is a lot of solutions.
You could transform your script to be a daemon, so when you launch it, it go directly to the background and continue to run until the server is shut down (or the program crash). But in that case, do your bot will re-run if you (or somebody else) restart the computer (server) ? There is some python libraries for this purpose, like daemonize.
Another common solution is to run your bot in a process manager. You can check supervisorctl for example, or you could decide to create a script to run your program from System V, UpStart or Systemd... This suppose you want to deploy your bot on a dedicated server or a VPS. This will be covered by the part 3 of the tutoriel you followed:
The next and final part of this series will [...] be demonstrating how to deploy the Bot to a VPS.
You could also consider encapsulating your bot into an image or a container (Docker, etc.) to run it on a compatible platform.
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Q:
BizTalk AS/2 implementation certificates
I cannot add any certificates on AS2 messages in BizTalk.
So here's what I have for the moment (I have installed 2 certificates on the BizTalk machine using the same account as the on under which the Host Instance is running.
The 2 certificates are the following and placed in the locations:
\Personal\Certificates - My own certificate 'pfx'.
\Other People\Certificates - Party certificate 'cer'.
So far the importing of the certificates.
Now, when in BizTalk Administration, I go to Parties and I go on the agreement between the parties. In that window I go down to 'Signature certificate' and I check "Override group signing certificate". Then when I click "browse" I see:
"No certificate available."
"No certificates meet the application criteria".
Any idea on what's wrong here?
A:
I've found it. The certificates should be installed under the same instance that the BizTalk Administration Console is openend. Otherwise the certificates could not be found.
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Gary Stager says:
There are three competing visions of educational computing. Each bestows agency on an actor in the educational enterprise. We can use classroom computers to benefit the system, the teacher, or the student. Data collection, drill-and-practice test-prep, computerized assessment, or monitoring Common Core compliance are examples of the computer benefitting the system. “Interactive” white boards, presenting information or managing whole-class simulations are examples of computing for the teacher. In this scenario, the teacher is the actor, the classroom a theatre, the students the audience and the computer is a prop.
The third vision is a progressive one. The personal computer is used to amplify human potential. It is an intellectual laboratory and vehicle for self-expression that allows each child to not only learn what we’ve always taught, perhaps with greater efficacy, efficiency or comprehension. The computer makes it possible for students to learn and do in ways unimaginable just a few years ago. This vision of computing democratizes educational opportunity and supports what Papert and Turkle call epistemological pluralism. The learner is at the center of the educational experience and learns in their own way.
Too many educators make the mistake of assuming a false equivalence between “technology” and its use. Technology is not neutral. It is always designed to influence behavior. Sure, you might point to an anecdote in which a clever teacher figures out a way to use a white board in a learner-centered fashion or a teacher finds the diagnostic data collected by the management system useful. These are the exception to the rule.
While flexible high-quality hardware is critical, educational computing is about software because software determines what you can do and what you do determines what you can learn. In my opinion the lowest ROI comes from granting agency to the system and the most from empowering each learner. You might think of the a continuum that runs from drill/testing at the bottom; through information access, productivity, simulation and modeling; with the computer as a computational material for knowledge construction representing not only the greatest ROI, but the most potential benefit for the learner.
Piaget reminds us,“To understand is to invent,” while our mutual colleague Seymour Papert said, “If you can use technology to make things, you can make more interesting things and you can learn a lot more by making them.”
….
kindergarteners could build, program and choreograph their own robot ballerinas by utilizing mathematical concepts and engineering principles never before accessible to young children. Kids express themselves through filmmaking, animation, music composition and collaborations with peers or experts across the globe. 5th graders write computer programs to represent fractions in a variety of ways while understanding not only fractions, but also a host of other mathematics and computer science concepts used in service of that understanding. An incarcerated 17 year-old dropout saddled with a host of learning disabilities is able to use computer programming and robotics to create “gopher-cam,” an intelligent vehicle for exploring beneath the earth, or launch his own probe into space for aerial reconnaissance. Little boys and girls can now make and program wearable computers with circuitry sewn with conductive thread while 10th grade English students can bring Lady Macbeth to life by composing a symphony. Soon, you be able to email and print a bicycle. Computing as a verb is the game-changer.
Used well, the computer extends the breadth, depth and complexity of potential projects. This in turn affords kids with the opportunity to, in the words of David Perkins, “play the whole game.” Thanks to the computer, children today have the opportunity to be mathematicians, novelists, engineers, composers, geneticists, composers, filmmakers, etc… But, only if our vision of computing is sufficiently imaginative. | {
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Subsets and Splits