Consider the following premises. forall x_10: ~R_10(x_10). t_1 <-> R_10(j). Can we infer ~t_1 from them?
 From forall x_10: ~R_10(x_10) we can infer ~R_10(j). From t_1 <-> R_10(j) we can infer t_1 -> R_10(j). Finally, from t_1 -> R_10(j), ~R_10(j) we can infer ~t_1. Therefore, the answer is yes.