Jorge has two children, Carlos and Sofia. Carlos is married to Ana, and they have a daughter named Isabel. Sofia is married to Luis, and they have two sons, Miguel and Diego. Describe the relationships between Isabel and Miguel, and between Ana and Diego. Additionally, is Luis Jorge's son?
Respond very briefly.
Isabel is the daughter of Carlos who is Sofia's brother. This makes Isabel Sofia's niece. Since Sofia is married to Luis, and Luis is Miguel's father, Isabel and Miguel are cousins, because their respective parents, Carlos and Sofia, are siblings.

Ana is married to Carlos, making her Sofia's sister-in-law. Because Sofia is Diego's mother and Luis is Diego's father, Ana is Diego's aunt by marriage.

Luis is not Jorge's son; he is Jorge's son-in-law. This is because Luis is married to Jorge's daughter, Sofia. Jorge's children are Carlos and Sofia, which makes Luis a part of the family through marriage rather than by birth.