Consider the following premises. R_10(e_3) or q. forall x_10: R_10(x_10) -> S_10(x_10). r_1 -> S_10(e_3). q -> r_1. Can we infer ~S_10(e_3) from them?
 From forall x_10: R_10(x_10) -> S_10(x_10) we can infer R_10(e_3) -> S_10(e_3). From q -> r_1, r_1 -> S_10(e_3) we can infer q -> S_10(e_3). Finally, from R_10(e_3) -> S_10(e_3), q -> S_10(e_3), R_10(e_3) or q we can infer S_10(e_3), which contradicts ~S_10(e_3). Therefore, the answer is no.