Consider the following premises. forall x_10: R_4(x_10) -> S_10(x_10). S_10(e) -> ~q_2. q_2. Can we infer ~R_4(e) from them?
 From forall x_10: R_4(x_10) -> S_10(x_10) we can infer R_4(e) -> S_10(e). From S_10(e) -> ~q_2, q_2 we can infer ~S_10(e). Finally, from R_4(e) -> S_10(e), ~S_10(e) we can infer ~R_4(e). Therefore, the answer is yes.