Maria has three children: Rosa, Carlos, and Luisa. Carlos is married to Sofia, and they have a son named Diego. Luisa is married to Miguel, and they have two children, Ana and Pablo. Maria has a brother named Jose. How are Sofia and Miguel related to Maria, and how is Jose related to Luisa's children?

Make your response very short.
Sofia is Maria's daughter-in-law, because she is married to Maria's son, Carlos. Miguel is also Maria's son-in-law, due to his marriage to Maria's daughter, Luisa. Jose is the brother of Maria, which makes him the uncle to Maria's children including Luisa. Consequently, Jose is the great-uncle of Luisa's children, Ana and Pablo.