It&#x27;s indeed not new at least for some markers it was known to be unreliable for a (relatively) long time: <a href="http:&#x2F;&#x2F;www.ncbi.nlm.nih.gov&#x2F;pubmed&#x2F;9365861" rel="nofollow">http:&#x2F;&#x2F;www.ncbi.nlm.nih.gov&#x2F;pubmed&#x2F;9365861</a>