<i>However, observing people on psychedelics with fMRIs does not match with that.</i><p>This study would appear to disagree:
<a href="http:&#x2F;&#x2F;www.pnas.org&#x2F;content&#x2F;109&#x2F;6&#x2F;2138" rel="nofollow">http:&#x2F;&#x2F;www.pnas.org&#x2F;content&#x2F;109&#x2F;6&#x2F;2138</a><p><i>Decreased activity in the ACC&#x2F;medial prefrontal cortex (mPFC) was a consistent finding and the magnitude of this decrease predicted the intensity of the subjective effects. Based on these results, a seed-based pharmaco-physiological interaction&#x2F;functional connectivity analysis was performed using a medial prefrontal seed. Psilocybin caused a significant decrease in the positive coupling between the mPFC and PCC. These results strongly imply that the subjective effects of psychedelic drugs are caused by decreased activity and connectivity in the brain&#x27;s key connector hubs, enabling a state of unconstrained cognition.</i>