As a cancer biologist I feel that the reliance on biomarkers as indicators of biology is a poor way to do science. Biology is about complex, interacting networks; models that attempt to reduce it to a few controlling variables is almost always wrong (as in, the model is insufficiently predictive), and moreover misses the point: we need to understand biology in all of its rich interactions, not pare it down to the math we can handle. Biology is not physics; two or three factor models won&#x27;t cut it.