For lack of a response from someone who has actually tried getting ASIO working on such a setup, I suggest you just try it.  Grab a Live CD and a spare external hard drive and just give it a whack.  Passing through the sound cards should work.  USB might be trickier if you&#x27;re not just passing through a whole USB hub.  But considering how new IOMMU is, I imagine the intersection between people who have tried it and people who use Cubase is incredibly tiny.