I don&#x27;t think there are specific guidelines as to when you start calling something a candidate or not, although I personally wouldn&#x27;t call a &quot;hit&quot; from a screen a &quot;candidate&quot;.  Everything I am working with is a natural product derivate, In fact, engineered to reduce tox of a compound that started off in late-stage preclinicals, so the odds of success are (qualitatively) higher to begin with.<p>&gt;Extensive pharmacological testing in cultured cells and animals is much, much harder.<p>And that&#x27;s why I&#x27;m contracting CROs for those parts.  I guess technically that&#x27;s &quot;taking out of the garage&quot;, but I never said the whole thing is being done in the garage!