Maybe it's different in OS X, but my (admittedly single) large screen doesn't pose a problem. If I'm mousing from one corner to another, I move the mouse more definitively and I cross the screen in 3.5 inches of mouse travel (just tested). When I'm near a button I move the mouse more tentatively, and one inch of cursor travel corresponds to an entire inch of mouse travel.<p>So it's not just cursor <i>speed</i>, but acceleration that matters. And if it's implemented properly, I don't think your issue would be an issue at all.