EVE Online did autogenerated content for most of the base universe: the devs even noted that the random seed they used for the universe was "42".  Of course, quests and such were hand-crafted later, this was just for the names, star systems, connections between them, NPC-controlled space stations, planets, moons, asteroid belts, resources, etc.<p>The real problem IMO is that autogenerated content can't be any more inherently interesting than the algorithm that created it.  In EVE, this wasn't a problem, because the autogenerated content was merely intended as a "playing field" on which other events happened, but if the autogenerated content <i>is the content itself</i>, I think you'll have serious problems making it non-repetitive.