Someone comes to me without any credible evidence and states "I think statins cause cancer. Let us randomize people with high LDL to statins or placebo." I will reject this study, not because my mind is "made up" and I am stubborn, but because the prior probability is low (due to lack of credible evidence) that statins truly lead to an excess of cancer, whereas the evidence supporting the use of statins to reduce death in those with high LDL is of gargantuan proportions.<p>So while I am sorry that we as a medical community have not succeeded in making it clear why no randomized trial should be conducted for vaccines given the current evidence, I reject the assertion that this is simply because "my mind is made up."