There are a couple of what are called "gadget plays" that include what you might call multiple passes, such as the "flea flicker" but they are not frequently used because of the extreme danger of turnovers. Even the professional quarterbacks don't always manage to throw a pass without turning the ball over. At the pro level, the defenses are so athletic and so good that you just don't want to risk losing the ball, so it's only done in circumstances predicted to take advantage of its unexpectedness. There are also rules-based reasons why you cannot make multiple passes downfield, but I might as well try explaining the infield fly rule to someone who's never heard of baseball - it gets complicated fast.