We're a django shop and that's essentially what we do. We already use the django template engine in our javascript/css files (primarily for URL generation, but it's grown to be several other things). We plugged in Sass and it's been great.<p>The development servers passes CSS files through the django template engine and Sass every time it's served. In production we do it just during deployment. Thus what sits on our CDN is the end result. From a developers pesrpective your always editing the 'source' file not the 'compiled' version.<p>It's seamless and works great.