As Jeff Bezos likes to say: Frugality breeds innovation.<p>The availability of money changes how you go about doing business, but not your chances of success. In my experience Seattle entrepreneurs are much more focussed on building a serious business, while Valley entrepreneurs are focussed on building the most awesome toys in the world (we'll make money eventually, right?). Consequently, valley companies have fanboys, while Seattle companies have fancorps. Both can make a lot of money. On the short run I would put my money in San Francisco since the boys can be very excited. On the long run I would put my money in Seattle since the corps won't lose interest over time.