Interesting that he left out the iPhone.  To me, that is the most recent big innovation in usability.  Of course, it is a different form factor than the PC, and that is the point.  There is not much reason for a radical change in interface if the form factor doesn't change.<p>The other big example is Wii, and now what Microsoft has been demoing in their Natal project (assuming it ships in the near future).  In these cases, the key factor is that you are operating a device from a distance.  That allows the use of a wider range of human motion in controlling the device, now that the technology to support it exists.<p>I suppose the lesson is, form factor and innovative interface design cannot be decoupled.