No-reply is useful when you want the person on the other end to reply by taking specific actions. I helped an organisation migrate annual dues to e-mail+credit card invoicing. the emails went out from the (active) info@ alias.<p>However, we included a link to get in touch with your local membership officer, to cancel membership etc. which would be completely automated, but we'd get loads of replies relating to those things, and spend quite some time processing those.<p>After we started sending from a no-reply and just included the contact-email in the mail-body, we didn't get a single e-mail related to those.<p>We might have pissed off some people who couldn't be bothered to read beyond the first five words, but I don't really care.