I started using Dvorak out of curiosity more than anything. I've been using it for close to 4 years now, and I haven't noticed any speed gains.<p>It's inconvenient to use other peoples' computers; although, this is offset a bit by the amusement value of watching others try to use my machine.<p>The claims about ergonomics may be valid. My hands move a lot less when using Dvorak, but I can't speak as to whether the chances of RSI are reduced in any way by this, or if it provides any kind of relief.<p>Programming-wise, I haven't had any problems. The biggest concern there is that you might not be able to type for the first week or two.<p>Unless you have some significant reason to do so, I don't think I would recommend switching myself. I didn't see any significant gains, but your mileage may vary.