Peto’s Paradox is the very interesting background to this [1].<p>1. <a href="https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;Peto%27s_paradox" rel="nofollow">https:&#x2F;&#x2F;en.wikipedia.org&#x2F;wiki&#x2F;Peto%27s_paradox</a>