<i>Putting my biologist hat on, I don&#x27;t want to dismiss it, consider it to be interesting,</i><p>Thank you.<p>I would be happy to discuss it with you further.<p>I do not know what you mean by <i>CF is a regulatory derangement.</i><p>It is caused by a defect in a specific cell channel that manages traffic of specific molecules into and out of the cell. I have paid enormous attention to that and kind of ignored the hand-wavy and apparently incorrect mental models popular in the medical literature. For example, the official explanation on the CF Foundation website is that people with CF are <i>drowning in an excess of mucus</i>. I found one study that says we produce too little mucus, not too much. This fits with my firsthand experience, it more logically fits with the fact that mucus is a protective coating that helps keep out germs and it fits with the extremely well known and well established fact that women with CF suffer vaginal dryness that often seriously interferes with their sex lives. I think we cough up phlegm, not mucus -- ie infection -- and if you improve mucus production, you reduce infection and see less phlegm. I have seen that hypothesis work effectively for me and my oldest son who has the same diagnosis I have. I have explained it to one woman with CF who was out of time and dying and tracked me down after I left all CF lists and took down my health site. She is gradually getting healthier.<p>So that is a very long way of saying that a) I have no idea what you mean by that phrase and b) the odds are high that you and I have completely different mental models for what is going on with CF.