Citing the article, &quot;while a decrease in symptoms at puberty is common for boys, the opposite is true for girls, whose symptoms intensify as estrogen increases in their system&quot;. IANA doctor or chemist but if there is interaction with hormones, it&#x27;s probably different on a chemical level.<p>By which I mean that the brain chemistry is affected in the same way by ADHD but interaction with sexual hormones changes behaviour in different ways.