&gt; Also, there are actually a lot of people who deny any psychological involvement with depression, and you&#x27;ll see this a lot on forums (including HN).<p>To be fair, a lot of psychotherapy advocates claim the same thing about physiological causes. This is kind of funny because the first step in a mood disorder diagnosis is <i>supposed</i> to be the elimination of physiological explanations, but in practice that process is often... let&#x27;s be kind to the GPs&#x2F;PCPs and say &quot;optimized for time&quot;.<p>Basically, anyone who claims to have the one true solution to depression is either lying or believes a little too much in their own hype. Some are people who got lucky and had their first treatment work wonders (not a typical experience) and now think that everyone with depression needs to try their specific treatment, but a lot are people with a financial, reputational, or ideological stake in people&#x27;s beliefs about treatment.<p>On one hand, depression treatment is certainly a case of &quot;you miss 100% of the shots you don&#x27;t take&quot; [1]. On the other hand, it&#x27;s also a case of &quot;it is possible to commit no mistakes and still lose; that is not a weakness, that is life&quot; [2].<p>[1]: popularly attributed to Wayne Gretzky<p>[2]: Jean-Luc Picard; Star Trek: The Next Generation 02x21 Peak Performance