If you&#x27;re looking at a single, stand alone hypervisor, then the differences are not enormous. You could pick your flavor based on whatever you&#x27;re comfortable with.<p>When you&#x27;re looking at larger scale and the potential for unique and&#x2F;or fringe cases goes up, then support for those becomes a differentiator. VMware rather excels here I think, with support for device pass-through and higher resource limits. GPU acceleration, Raw Device Mapping, are some of the ones I can think of.<p>A little past that and it&#x27;s interaction between hypervisors. ESXi and KVM will do live migration, but KVM doesn&#x27;t have DRS (yet). I don&#x27;t think Hyper-V has storage live migration yet, but ESXi does. And so on.<p>They&#x27;ll all catch up, I&#x27;ve no doubt. I&#x27;m particularly interested to see Nutanix with their Acropolis&#x2F;KVM hypervisor gain these features. But right now, ESXi is in the lead.