<i>While adjusting for BMI eliminates the effect, this does not mean that dietary fat is not important</i><p>If the effect goes away when controlling for BMI, I&#x27;d say that&#x27;s a pretty weak link.<p><i>A large body of experimental data generated in laboratory animals strongly supports the notion that high-fat diets are associated with impaired insulin action</i><p>&quot;in laboratory animals&quot;<p>Color me skeptical, but lots of things happen in animals that don&#x27;t happen in humans.  Animal studies are suggestive, but hardly conclusive.<p>Sound tenuous to me.  But I&#x27;m also weighing that against a large body of research that suggests that high-fat, low-carb, moderate protein diets are a very healthy diet... possibly optimal for some people.