My original post is correct. APOE 4&#x2F;4 is sensitive to dietary fat; high fat diets cause large LDL [0]. Further, fat causes atherosclerosis in APOE 4&#x2F;4 individuals more quickly than others [1].<p>It would make sense that APOE 4&#x2F;4 would have this effect, because it is the &quot;defective&quot; form of APOE. Individuals with APOE 4&#x2F;4 do not clear oxidized fats from the brain as quickly as APOE 2 or 3 individuals.<p>[0] <a href="http:&#x2F;&#x2F;jn.nutrition.org&#x2F;content&#x2F;134&#x2F;10&#x2F;2517.full" rel="nofollow">http:&#x2F;&#x2F;jn.nutrition.org&#x2F;content&#x2F;134&#x2F;10&#x2F;2517.full</a>
[1] <a href="http:&#x2F;&#x2F;www.ncbi.nlm.nih.gov&#x2F;pmc&#x2F;articles&#x2F;PMC2674716&#x2F;" rel="nofollow">http:&#x2F;&#x2F;www.ncbi.nlm.nih.gov&#x2F;pmc&#x2F;articles&#x2F;PMC2674716&#x2F;</a>