One of the startups that fizzled out was Nanorex, which is where Nanoengineer was made. Thankfully they were open to releasing the source code and version control repository when they decided to shutdown. The results of that are here: <a href="https:&#x2F;&#x2F;github.com&#x2F;kanzure&#x2F;nanoengineer" rel="nofollow">https:&#x2F;&#x2F;github.com&#x2F;kanzure&#x2F;nanoengineer</a><p>I think everyone is stuck wondering how to make the tooltips from the tooltips paper: <a href="http:&#x2F;&#x2F;diyhpl.us&#x2F;~bryan&#x2F;papers2&#x2F;nanotech&#x2F;Optimal%20tooltip%20trajectories%20in%20a%20hydrogen%20abstraction%20tool%20recharge%20reaction%20sequence%20for%20positionally%20controlled%20diamond%20mechanosynthesis.pdf" rel="nofollow">http:&#x2F;&#x2F;diyhpl.us&#x2F;~bryan&#x2F;papers2&#x2F;nanotech&#x2F;Optimal%20tooltip%2...</a><p>All of that was motivated by goals of making nanofactories like shown in this eye candy video: <a href="http:&#x2F;&#x2F;www.youtube.com&#x2F;watch?v=vEYN18d7gHg" rel="nofollow">http:&#x2F;&#x2F;www.youtube.com&#x2F;watch?v=vEYN18d7gHg</a><p>Because positional, precise molecular manufacturing still doesn&#x27;t exist, I have been increasingly interested in using DNA synthesis (using phosphoramidite chemistry) to combinatorially build proteins that lock together in pre-defined shape based on ligand-specific binding affinities between the blocks. The Nanosystems book left out a lot of biology that can be hijacked to help out goals like these.<p>Long-term we might be able to coerce enzymes into creating molecular machines anyway: <a href="https:&#x2F;&#x2F;groups.google.com&#x2F;group&#x2F;enzymaticsynthesis" rel="nofollow">https:&#x2F;&#x2F;groups.google.com&#x2F;group&#x2F;enzymaticsynthesis</a>