&gt; I must be missing something; any thoughts?<p>Since the beginning of the era of modern psychedelic research, no one has developed any serious longterm mental illness as the result of taking psychedelics in a research setting. And this is out of thousands of people.<p>I think part of the reason is that it&#x27;s actually a lot easier to determine if someone is predisposed to mental illness than it actually is to determine if the person sitting in front of you has a mental illness. E.g. if one of your parents was bipolar or you had a relative who committed suicide then you&#x27;d be immediately excluded from any trial. And because they are only doing this research on adults, this means that participants would have all had 20+ years to figure out if their parents have signs of mental illness or whatever.