Actually, protein design is fairly routine now.  We used Exacycle, an idle-cycle computer at Google, to show that given reasonable amounts of computer time, design of proteins is a straightforward process.  You don&#x27;t need advanced supercomputers or even GPUs to solve this problem- just classic clusters- although GPUs (not supercomputers) speed up the rate significantly.<p>The important reason why this works is that while &quot;protein folding is an NP-hard problem&quot; is technically true for computer scientists, the more important fact is &quot;we have approximations to the NP-hard problem that are good enough to finish in hours if you have a 600Kcores working on it&quot;.