&gt; Hypothyroidism<p>Accounts for about 10 extra pounds on a normal-sized human.  Didn&#x27;t stop me from losing 35 pounds in four months when I was 100 pounds overweight.<p>&gt; PCOS<p>Same as above, assuming PCOS is a cause and not an effect.  There seems to be some debate on that in the Ob-Gyn community.<p>&gt; Cushing&#x27;s syndrome<p>Cushing&#x27;s is fairly rare, and is usually curable.<p>&gt; complications of depression<p>Yes, depression is a big psychological cause of overeating.  Been there.  Disentangling the depression from the food is part of the therapy, though.  Particularly since it becomes a self-reinforcing cycle where depression begets comfort eating which begets more depression.<p>&gt; The accusation was that these cases are self-inflicted. It&#x27;s WAY more complicated than that.<p>Always self-inflicted? No.  More complicated?  Yes.<p>However, except in rare circumstances every underlying condition is treatable or curable.  There are synthetic hormones for hypothyroidism.  There are cortisol blockers, surgeries, and other treatments for Cushing&#x27;s.  PCOS is incurable but treatable, ironically considering the subject by <i>weight loss</i>.  Depression is treatable, though it can be a struggle.<p>Obesity may not be self-inflicted in all cases, but it is almost always resolvable.  I&#x27;m resolving it, despite having two of the things you listed.  You can&#x27;t just throw your hands up and complain about &quot;conditions&quot; as an excuse to not do anything about the problem.  Hell, everything you listed has potentially serious problems if untreated even if it doesn&#x27;t cause weight gain.