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You can take levothyroxine either one hour before meals or two hours after eating and one hour before taking other meds and any vitamins and supplements but two hours before taking iron or calcium. Source(s): I'm a nurse. Nope, your supposed to take it on an empty stomach, then eat an hour or so after you take it.
I'm wondering if taking the synthroid I normally wait 4 hours to eat after taking the pill so perhaps my stomach is too empty for too long and the medicine is causing the shakiness because there is nothing at all but synthroid in my system. . . Just starting my thyroid medicine for life thing with levothyroxine.