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You can take levothyroxine either one hour before meals or two hours after eating and one hour before taking other meds and any vitamins and supplements but two hours before taking iron or calcium. Source(s): I'm a nurse. Nope, your supposed to take it on an empty stomach, then eat an hour or so after you take it.
Studies Show TSH Levels Lower When Levothyroxine Taken at Bedtime. Thyroid Disease. By Mary Shomon - Reviewed by a board-certified physician. Every thyroid patient has heard the advice that for best results, we should take our medication first thing in the morning, on an empty stomach, and wait at least 30 minutes to an hour before eating. (And also, that we should wait for at least three to four hours before taking calcium or iron, which can interfere with thyroid hormone absorption.)