certificate of analysis. Definition. A document issued by a regulatory or quality assurance entity verifying the adherence to product specifications and standards of production of certain products such as food products and drugs. The certificate usually includes the actual test results performed on the product batch.
Tay-Sachs disease is caused by a mutation in the HEXA gene located on chromosome 15. Tay-Sachs follows an autosomal recessive pattern of inheritance. With the help of the diagram, identify which of the offspring will be an unaffected carrier.
Back to Top Causes. Tay-Sachs disease occurs when the body lacks hexosaminidase A, a protein that helps break down a chemical found in nerve tissue called gangliosides. Without this protein, gangliosides, particularly ganglioside GM2, build up in cells, especially nerve cells in the brain.ay-Sachs disease is caused by a defective gene on chromosome 15. When both parents carry the defective Tay-Sachs gene, a child has a 25% chance of developing the disease. The child must receive two copies of the defective gene -- one from each parent -- in order to become sick.