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1 Ghrelin is secreted by endocrine cells in the stomach, especially when one is hungry and. 2  acts on the hypothalamus to stimulate feeding. 3  This action counteracts the inhibition of feeding by leptin and PYY3-36. Ghrelin is secreted by endocrine cells in the stomach, especially when one is hungry and. 2  acts on the hypothalamus to stimulate feeding. 3  This action counteracts the inhibition of feeding by leptin and PYY3-36.
Your gut synthesizes a host of small molecules which can directly signal the brain. One of these, called ghrelin, is synthesized primarily in the stomach, and is produced when the stomach is empty. Ghrelin released into the blood ultimately finds its way into the brain, and crosses the blood-brain barrier to reach a part of the brain called the hypothalamus. Now, the hypothalamus has two interesting types of cells.