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Vomiting often can throw your electrolytes out of balance. Low levels of potassium, magnesium, and sodium are not uncommon. This is hard on the heart and can cause irregular heartbeat (arrhythmia), weakened heart muscle, and heart failure. Bulimia can cause low blood pressure, weak pulse, and anemia. Throwing up can be a violent event. The sheer force of it can even cause blood vessels in the eyes to rupture.
If you took enough to kill yourself, you will probably die from a heart attack. Opiates and other downers: Well, your blood pressure is going to drop making you feel light-headed. You are going to become sleepy, very sleepy in fact and your going to throw up because your very nauseated. do hope that you are not planning on overdosing and that it is just a curiosity question. If however you are feeling suicidal, please, please call 911 and accept the help that will be offered to you. I've been in this position myself and life can get better if you work hard and give yourself a chance.