Word Origin and History for mesopotamian. ancient name for the land that lies between the Tigris and Euphrates rivers (in modern Iraq), from Greek mesopotamia (khora), literally a country between two rivers, from fem. of mesopotamos, from mesos middle (see medial (adj.)) + potamos river (see potamo-).
Monogenic forms, caused by a single mutation in a dominantly or recessively inherited gene, are well-established, albeit relatively rare types of PD. They collectively account for about 30% of the familial and 3%â5% of the sporadic cases.
The term monogenic obesity requires some specification and discussion: a âmonogeneâ is by common textbook definition, a gene with a strong effect on the phenotype [Mendelian traits or Mendelian (single gene) conditions], giving rise to a (close to) one-to-one relationship between genotype and phenotype.he brain derived neurotrophic factor (BDNF) is involved in weight regulation downstream of the MC4R. Mutations in single genes of the leptinergicâmelanocortinergic pathway have been shown to have a monogenic effect on the development of obesity.