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Quadriceps weakness can be caused by various injuries to the knee or hips, acquired myopathies (diseases that affect muscle tissue) such as Lyme disease and poliomyelitis, inherited myopathies such as certain muscular dystrophies and stroke, or neurological diseases such as multiple sclerosis or Bellâs palsy.
Common Injuries to the Quadriceps. Injury to the quad muscles can occur. Sometimes, the muscle tears off the bone just below the kneecap, resulting in a dislocated kneecap. This is almost always the result of trauma, such as a sports injury or fall.