certificate of analysis. Definition. A document issued by a regulatory or quality assurance entity verifying the adherence to product specifications and standards of production of certain products such as food products and drugs. The certificate usually includes the actual test results performed on the product batch.
Tay-Sachs disease is caused by a mutation in the HEXA gene located on chromosome 15. Tay-Sachs follows an autosomal recessive pattern of inheritance. With the help of the diagram, identify which of the offspring will be an unaffected carrier.
Mutations in the HEXA gene cause Tay-Sachs disease. The HEXA gene provides instructions for making part of an enzyme called beta-hexosaminidase A, which plays a critical role in the brain and spinal cord.ecause Tay-Sachs disease impairs the function of a lysosomal enzyme and involves the buildup of GM2 ganglioside, this condition is sometimes referred to as a lysosomal storage disorder or a GM2-gangliosidosis. Read more about the HEXA gene.