Congress has authorized FDA to collect an annual establishment registration fee for device establishments. A detailed list of the types of device establishments that are required to register and pay the fee can be found at Who Must Register, List and Pay the Fee. The establishment registration fee is not eligible for a reduced small business fee. The schedule of annual registration user fees for fiscal years 2017 through 2018 follows:
Overall, most patients reported experiencing at least one warning sign of acute coronary syndrome in the week prior to their event. The most common symptoms were similar among men and women and included unusual fatigue, sleep disturbances, anxiety and arm weakness or discomfort.
Figure C is a cross-section of the coronary artery with plaque buildup and a blood clot. The most common heart attack symptom is chest pain or discomfort. Most heart attacks involve discomfort in the center or left side of the chest that often lasts for more than a few minutes or goes away and comes back.