Mutations in the CSA or CSB complementation genes cause the Cockayne syndrome, a severe genetic disorder that results in patientsâ death in early adulthood. CSA and CSB act in a transcription-coupled repair (TCR) pathway, but their functional relationship is not understood. We have previously shown that CSA is a subunit of an E3 ubiquitin ligase complex. Here we demonstrate that CSB is a substrate of this ligase: Following UV irradiation, CSB is degraded at a late stage of the repair process in a proteasome- and CSA-dependent manner. Moreover, we demonstrate the importance of CSB degradation for post-TCR recovery of transcription and for the Cockayne syndrome.
Every year, over 100 million cell phones are made obsolete. The average life span of a cell phone is just 18 months. The average American cell phone user owns three or more cellular phones. Up to 75% of obsolete phones are stockpiled in drawers, including the battery and the charger [8]
How long does your iphone 5c battery last? I have had my 5c for three months and within the past month I have noticed the battery life is way shorter than before.My phone will die after 11 hours of standby and less than one hour of actual use that consists of texting and maybe a bit of candy crush. Both apple and Verizon employees have told me this seems...And yes I have tried every suggestion under the sun to extend the battery life.). Update: I mean that it dies after 11 hours of standby and 1 hour of use, so 12 hours total after a full charge.