In the present study, we investigated how the Bcl-2 family relates to the ceramide-mediated apoptotic pathway induced by etoposide (VP-16), cisplatin (CDDP), or TNF-using C6 rat glioma cells and U87-MG human glioblastoma cells transfected with bax or bcl-2 gene.igure 3 Effects of Bcl-2 or Bax overexpression on ceramide formation and neutral sphingomyelinase activation in etoposide-treated C6 cells. C6/Neo (), C6/Bcl-2 (), and C6/Bax () cells were treated with 40 M etoposide for indicated periods.
Full time minimum wage workers in Michigan earn a total of $356.00 per week and approximately $18,512.00 per year (based on a 8 hour days and a 260-day work year) before taxes. The federal poverty threshold for a household of two is $14,570 per year.
The petition not only raises the minimum wage to $10.10 over the next three years, it completely eliminates the tip credit in Michigan and then indexes that wage to inflation going forward. They now have until May 28 to collect 258,088 signatures in order for the petition to appear on the November ballot.