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In iron deficiency, the iron level is low but the TIBC is increased, thus transferrin saturation becomes very low. In iron overload states, such as hemochromatosis, the iron level will be high and the TIBC will be low or normal, causing the transferrin saturation to increase. UIBC may be ordered as an alternative to TIBC.
What is carbohydrate deficient transferrin? Transferrin is a glycoprotein found in the blood that transports iron. Amino acids bind the iron to the transferrin, once this amino acid process has completed, the transferrin undergoes further modification by the addition of carbohydrate side-chains.