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How much to take for the treatment of cold sores. If you have been prescribed Valtrex 500 mg tablets, the normal dose to take for the one day regimen is four tablets with water twice a day, with the second dose taken about 12 hours after the first dose.altrex tablets are used for the treatment of shingles (herpes zoster), ophthalmic zosters (shingles affecting the eye region) and cold sores (herpes labialis). Valtrex tablets work by stopping the multiplication of the virus which causes shingles and cold sores.
Valtrex's website recommends that the drug be taken once during the prodrome of a cold sore (the aura associated with cold sores that can include burning, itching or tingling feeling in the area) and then again 12 hours later. Antiviral treatment has not shown to be effective in treating cold sores after they occur.alacyclovir is used to shorten the duration and severity of shingles symptoms and to help stop new sores from forming. Valacyclovir should be started soon after the shingles rash appears and is taken is normally taken in a week-long regimen.