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You can take levothyroxine either one hour before meals or two hours after eating and one hour before taking other meds and any vitamins and supplements but two hours before taking iron or calcium. Source(s): I'm a nurse. Nope, your supposed to take it on an empty stomach, then eat an hour or so after you take it.
Report Abuse. Taking levothyroxine with food can decrease the amount of medicine that gets into your blood stream. Taking it on an empty stomach will help you to get the most benefit from the drug.If you forget to take it before you eat then take it as soon as you remember even if you are eating.est Answer: Levothyroxine is better absorbed by your body on an empty stomach. Which means it works at its best like this. It will probably still work if you take it during or after a meal and nothing bad will happen.