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You can take levothyroxine either one hour before meals or two hours after eating and one hour before taking other meds and any vitamins and supplements but two hours before taking iron or calcium. Source(s): I'm a nurse. Nope, your supposed to take it on an empty stomach, then eat an hour or so after you take it.
You'll need to take levothyroxine every day, most likely as a lifelong treatment. Certain foods, vitamins and chemical compounds can interfere with the absorption of levothyroxine, especially vitamin supplements high in iron and calcium.onclusion. Any vitamin supplement that you and your doctor agree should be added to your diet can be taken with levothyroxine, provided that you don't take your vitamin or supplement within four hours of taking your thyroid replacement hormone.