Once the fentanyl patch is removed, the patient may be transitioned to morphine by administering half of the morphine-equivalent dose in immediate release (IR) formulation every 4 hours for 2 to 4 days, until the lowest possible pain level is maintained.
Protostomia (from Greek meaning mouth first) are a clade of animals. Together with the deuterostomes and other phyla, they make up the Bilateria, mostly comprising animals with bilateral symmetry and three germ layers. The major distinctions between deuterostomes and protostomes are found in embryonic development.In animals at least as complex as earthworms, the embryo forms a dent on one side, the blastopore, which deepens to become the archenteron, the first phase in the growth of the gut. Most protostomes are schizocoelomates, meaning a solid mass of the embryonic mesoderm splits to form a coelom. 2  A few, such as Priapulids, have no coelom, but they may have descended from schizocoelomate ancestors.
On the basis of embryonic development, metazoans are divided into Protostomia and Deuterostomia. Protostomes are primitive invertebrates while deuterostomes include echinoderms and chordates.