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RhoGAM is used for: Preventing certain blood problems that may occur during pregnancy or blood transfusion. It may also be used for other conditions as determined by your doctor. RhoGAM is an immunoglobulin (Ig), which contains antibodies to the Rho(D) antigen. Exactly how it works is unknown.
It is safer to take that risk only once. If the only available blood for a Rh negative victim is Rh positive blood, Rhogam may be used, in very large doses of 25-30, full-size, 300 microgram ampoules, IV, per unit of blood, to neutralize the Rh sensitizing effects of the Rh positive blood.