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In iron deficiency, the iron level is low but the TIBC is increased, thus transferrin saturation becomes very low. In iron overload states, such as hemochromatosis, the iron level will be high and the TIBC will be low or normal, causing the transferrin saturation to increase. UIBC may be ordered as an alternative to TIBC.
Transferrin Saturation in Hemochromatosis. In hemochromatosis, an important lab marker is the transferrin saturation percentage. Because the body is constantly absorbing more iron from food than it needs to, there is a constant influx of iron into the blood. Transferrin attempts to keep up with this excess by rapidly binding and transporting iron to the cells.