Word Origin and History for mesopotamian. ancient name for the land that lies between the Tigris and Euphrates rivers (in modern Iraq), from Greek mesopotamia (khora), literally a country between two rivers, from fem. of mesopotamos, from mesos middle (see medial (adj.)) + potamos river (see potamo-).
Monogenic forms, caused by a single mutation in a dominantly or recessively inherited gene, are well-established, albeit relatively rare types of PD. They collectively account for about 30% of the familial and 3%â5% of the sporadic cases.
The clinical disease in cystic fibrosis is initiated as a result of mutations in CFTR, and is therefore called a monogenic disorder. To date, there are over 1400 mutations reported within the CFTR gene (see Cystic Fibrosis Gene Analysis Consortium, www.genet.sickkids.on.ca/cftr/).The most prevalent mutation results in the deletion of phenylalanine at position 508 (Î´F508), and occurs on 70% of all cystic fibrosis chromosomes in the USA.ven with improved treatment and better outcomes, the median age of survival is only 36.8 years. The causative cystic fibrosis gene was identified in 1989, on chromosome 7q31, and was termed the CFTR gene.