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Tryptase (EC 3.4.21.59, ) is the most abundant secretory granule-derived serine proteinase contained in mast cells and has been used as a marker for mast cell activation.
Interpretation. Tryptase levels of 11.5 ng/mL or greater are indicative of either mast cell activation (as in anaphylaxis) or increased total mast cell levels (as in mastocytosis). The assay does not distinguish between Î± or Î² tryptase (both inactive monomeric and active tetrameric form).ryptase, however, diffuses at a slower rate into tissues than histamine, presumably because of its association with a large proteoglycan complex. Serum levels of tryptase peek in 1-2 hours after allergen provocation and can remain elevated for up to 12-24 hours.