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How much to take for the treatment of cold sores. If you have been prescribed Valtrex 500 mg tablets, the normal dose to take for the one day regimen is four tablets with water twice a day, with the second dose taken about 12 hours after the first dose.altrex tablets are used for the treatment of shingles (herpes zoster), ophthalmic zosters (shingles affecting the eye region) and cold sores (herpes labialis). Valtrex tablets work by stopping the multiplication of the virus which causes shingles and cold sores.
In the study, 1,856 patients were treated for a cold sore outbreak. The participants got one of three treatments: twice-daily Valtrex for one day, twice-daily Valtrex for one day followed by a lower-dose of twice-daily Valtrex on the second day, or a placebo for two days.ug. 27, 2002 -- Here's good news for cold sore sufferers. Just one day of treatment with a medication called Valtrex makes the unsightly, painful sores disappear faster.