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Bone remodeling (or bone metabolism) is a lifelong process where mature bone tissue is removed from the skeleton (a process called bone resorption) and new bone tissue is formed (a process called ossification or new bone formation).n imbalance in the regulation of bone remodeling's two sub-processes, bone resorption and bone formation, results in many metabolic bone diseases, such as osteoporosis.
Caldeira da Silva and Cerqueira suggest that mitochondrial uncoupling is an effective mimic of CR. In mitochondria, the electron transport chain uses electrons from glucose and lipids to pump protons across a membrane. This proton gradient can be used to make energy in the form of ATP through oxidative phosphorylation.The process is kind of like generating hydropower.he interesting thing about uncouplers is that they actually increase the pumping of protons across the mitochondrial inner membrane. The animals metabolize more fat and pump more protons to make up for the fact that the proton gradient is being depleted without making ATP. This brings us back to the activity question.