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Tryptase (EC 3.4.21.59, ) is the most abundant secretory granule-derived serine proteinase contained in mast cells and has been used as a marker for mast cell activation.
The tryptase blood test is usually ordered by the doctor to confirm a diagnose of anaphylaxis or mastocytosis. Anaphylaxis is an allergic reaction that makes breathing difficult, lowers blood pressure, and causes hives to develop on the skin.he tryptase test can measure the total tryptase level, which includes all four forms, or it can measure just the activated forms. A ratio of the total tryptase level to the activated forms is usually used to distinguish between anaphylaxis and mastocytosis. slide 3 of 5.