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Tryptase (EC 3.4.21.59, ) is the most abundant secretory granule-derived serine proteinase contained in mast cells and has been used as a marker for mast cell activation.
The tryptase test is a useful indicator of mast cell activation. Mast cells are large tissue cells present in highest amounts in the skin, the lining of the intestine and air passages, and the bone marrow.he tryptase test may be used: 1  To confirm a diagnosis of anaphylaxis. 2  Anaphylaxis is primarily diagnosed clinically, but a total tryptase may be ordered, along with a histamine test, to help confirm anaphylaxis as the cause of someone's acute symptoms.