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1 Ghrelin is secreted by endocrine cells in the stomach, especially when one is hungry and. 2  acts on the hypothalamus to stimulate feeding. 3  This action counteracts the inhibition of feeding by leptin and PYY3-36. Ghrelin is secreted by endocrine cells in the stomach, especially when one is hungry and. 2  acts on the hypothalamus to stimulate feeding. 3  This action counteracts the inhibition of feeding by leptin and PYY3-36.
The ghrelin hormone, discovered in 1999, is released primarily from cells in the stomach and travels to the brain. There, it interacts with both the hypothalamus (the brainâs physiological eating center) and the brainâs pleasure centers to arouse hunger.