In fact, degenerative arthritis is thought to involve the entire joint structure with erosion of articular cartilage, hypertrophy of bone at the margins of the affected joint, changes to the synovial membrane (i.e., joint lining), subchondral bone sclerosis, and involvement of the ligaments and periarticular muscles.
14 days: The bullseye rash of lyme disease takes about 14 days to show up. You could have an allergic reaction to a bug bite that will develop within a day. Infection from a bite, not lyme disease, starts getting worse after about 2-3 days.
Up to 20% of people infected with Lyme disease do not exhibit the rash. On dark-skinned people, the rash may resemble a bruise. In most patients, any rash fades completely after 3 - 4 weeks, although secondary rashes may appear during the later stages of disease.he bull's eye rash, which is considered the classic sign of Lyme disease, may take the following course: 1  It can first appear as a pimple-like spot, which expands over the next few days into a purplish circle. 2  The circle may reach up to 6 inches in diameter with a deeper red rim.