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biology of prions Dr. Stanley Prusiner coined the term prion in 1982, which he defined as a small infectious pathogen containing protein but apparently lacking nucleic acid . The prion protein (PrP) is the critical component of these agents and may, in fact, be its exclusive constituent.
All known prion diseases in mammals affect the structure of the brain or other neural tissue and all are currently untreatable and universally fatal. Prions are not considered living organisms because they are misfolded protein molecules which may propagate by transmitting a misfolded protein state.If a prion enters a healthy organism, it induces existing, properly folded proteins to convert into the misfolded prion form.In this way, the prion acts as a template to guide the misfolding of more proteins into prion form. In yeast, this refolding is assisted by chaperone proteins such as Hsp104p.hese refolded prions can then go on to convert more proteins themselves, leading to a chain reaction resulting in large amounts of the prion form. All known prions induce the formation of an amyloid fold, in which the protein polymerises into an aggregate consisting of tightly packed beta sheets.