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You can take levothyroxine either one hour before meals or two hours after eating and one hour before taking other meds and any vitamins and supplements but two hours before taking iron or calcium. Source(s): I'm a nurse. Nope, your supposed to take it on an empty stomach, then eat an hour or so after you take it.
Timing of Meals. Consumption of levothyroxine with certain foods can significantly reduce its absorption. Thyroid hormones levels can decrease if you take your medication with foods -- or foods that contain -- soybean flour, cotton seed meal, walnuts, dietary fiber, calcium or calcium fortified juices. These foods should be avoided within several hours of taking your medication.