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You can take levothyroxine either one hour before meals or two hours after eating and one hour before taking other meds and any vitamins and supplements but two hours before taking iron or calcium. Source(s): I'm a nurse. Nope, your supposed to take it on an empty stomach, then eat an hour or so after you take it.
Antacids often used to treat heartburn and other intestinal distress, including calcium products such as TUMS or ROLAIDS and other antacids, may have absorption-inhibiting effects on thyroid medications. People should take levothyroxine four to six hours before or after taking these antacids. Iron supplements (FEOSOL, SLOW FE) have been shown to reduce the effect of levothyroxine in some people, although the effect is highly variable from one person to another.