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Tryptase (EC 3.4.21.59, ) is the most abundant secretory granule-derived serine proteinase contained in mast cells and has been used as a marker for mast cell activation.
As assessed by immunoelectron microscopy, a proportion of neoplastic basophils (10%-50%) contained tryptase in their cytoplasmic granules (Figure 1). However, not all granules in a given cell appeared to be labeled. Also, the intensity of labeling in basophils varied from donor to donor.