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1 Ghrelin is secreted by endocrine cells in the stomach, especially when one is hungry and. 2  acts on the hypothalamus to stimulate feeding. 3  This action counteracts the inhibition of feeding by leptin and PYY3-36. Ghrelin is secreted by endocrine cells in the stomach, especially when one is hungry and. 2  acts on the hypothalamus to stimulate feeding. 3  This action counteracts the inhibition of feeding by leptin and PYY3-36.
In the last fifteen years, we've learned a lot about the hormonal influences. At least one of these was discovered accidentally, gherlin, a hormone secreted by the stomach that increases appetite. We learned of the importance of gherlin only by studying people who have had stomach bypass surgery for obesity (bariatric surgery).