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Quadriceps weakness can be caused by various injuries to the knee or hips, acquired myopathies (diseases that affect muscle tissue) such as Lyme disease and poliomyelitis, inherited myopathies such as certain muscular dystrophies and stroke, or neurological diseases such as multiple sclerosis or Bellâs palsy.
Thus, most patients with COPD will develop contractile fatigue of the exercising muscle after exercise to the limits of tolerance. Patients with severe disease (FEV1 <40% of predicted) were as likely to develop exercise-induced quadriceps fatigue (seven out of nine) as those with milder disease (10 out of 12) [9]. Healthy elderly individuals also develop exercise-induced quadriceps fatigue after cycle exercise to the limits of tolerance [10].