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In the 1980s, Welker voiced many recurring characters in the original Transformers animated series. He voiced several Decepticons, including the leader Megatron, Soundwave, Skywarp, Mixmaster, Laserbeak, Buzzsaw, Rumble, Frenzy, Ravage and Ratbat, as well as Autobots Mirage, Trailbreaker and Sludge.
He would voice Soundwave again, as well as take on the roles of Shockwave and Barricade, in the 3rd film, Transformers: Dark of the Moon (2011). And in Transformers: Age of Extinction (2014) he reprised his role as Galvatron, albeit with a much different voice as his performance in the 1980s series.