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You can take levothyroxine either one hour before meals or two hours after eating and one hour before taking other meds and any vitamins and supplements but two hours before taking iron or calcium. Source(s): I'm a nurse. Nope, your supposed to take it on an empty stomach, then eat an hour or so after you take it.
No soy no iron: Although the packaging for levothyroxine says to take it on an empty stomach for many people its not possible to do that and take it consistently each day. As long as you take it at a consistent time and don't take it with soy or with iron which will interfere with its absorption it is fine to take it with breakfast or before bed without being strictly fasting.