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Procedures such as laceration repair, which at one time required the use of painful infiltrative anesthetics, can now be accomplished safely and comfortably with the use of topical anesthetics. An additional advantage of topical anesthetics in laceration repair is that wound margins are not distorted.
The first is that volatile anesthetics, unlike most of the drugs used in medicine, bind only very weakly to their site(s) of action. As a result, high concentrations, often more than 1,000 times greater than for typical receptor-or protein-targeting drugs, are needed to achieve an anesthetic state. This makes it tricky to obtain structural details of anesthetics bound in a specific manner to a protein.