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Tryptase (EC 3.4.21.59, ) is the most abundant secretory granule-derived serine proteinase contained in mast cells and has been used as a marker for mast cell activation.
1 To confirm a diagnosis of anaphylaxis. 2  Anaphylaxis is primarily diagnosed clinically, but a total tryptase may be ordered, along with a histamine test, to help confirm anaphylaxis as the cause of someone's acute symptoms.3  This is especially true if the person has recurrent episodes and/or if the diagnosis is uncertain.he tryptase test may be used: 1  To confirm a diagnosis of anaphylaxis. 2  Anaphylaxis is primarily diagnosed clinically, but a total tryptase may be ordered, along with a histamine test, to help confirm anaphylaxis as the cause of someone's acute symptoms.