certificate of analysis. Definition. A document issued by a regulatory or quality assurance entity verifying the adherence to product specifications and standards of production of certain products such as food products and drugs. The certificate usually includes the actual test results performed on the product batch.
Tay-Sachs disease is caused by a mutation in the HEXA gene located on chromosome 15. Tay-Sachs follows an autosomal recessive pattern of inheritance. With the help of the diagram, identify which of the offspring will be an unaffected carrier.
Tay-Sachs disease is an inherited disease caused by an abnormal gene. People with this abnormal gene do not have an important enzyme called hexosaminidase A (HEXA) that helps to break down a fatty material called ganglioside GM2. This material builds up in the brain, and eventually damages nerve cells and causes neurological problems.