In fact, degenerative arthritis is thought to involve the entire joint structure with erosion of articular cartilage, hypertrophy of bone at the margins of the affected joint, changes to the synovial membrane (i.e., joint lining), subchondral bone sclerosis, and involvement of the ligaments and periarticular muscles.
14 days: The bullseye rash of lyme disease takes about 14 days to show up. You could have an allergic reaction to a bug bite that will develop within a day. Infection from a bite, not lyme disease, starts getting worse after about 2-3 days.
1 A ring-like red rash around the area of the tick bite -- The rash will resemble a bulls-eye and will appear within 3-30 days of the bite. 2  Flu-like symptoms (e.g.: fatigue, headache, fever, muscle or joint soreness)  Later- stage signs of Lyme disease include the following: