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Thick blood is caused by a variety of conditions, such as heavy proteins in the blood, too much blood in circulation or a blood clot system imbalance, according to Southeastern Medical Oncology Center. Diseases such as cancer and lupus can also lead to thick blood. Continue Reading.
1 In some cases of myeloma, excess protein in the blood can cause a condition called hyperviscosity syndrome. 2  The type and amount of immunoglobulin protein can result in thickening the blood beyond normal blood viscosity, which may result in alteration in a variety of bodily, including mental, processes.