In fact, degenerative arthritis is thought to involve the entire joint structure with erosion of articular cartilage, hypertrophy of bone at the margins of the affected joint, changes to the synovial membrane (i.e., joint lining), subchondral bone sclerosis, and involvement of the ligaments and periarticular muscles.
14 days: The bullseye rash of lyme disease takes about 14 days to show up. You could have an allergic reaction to a bug bite that will develop within a day. Infection from a bite, not lyme disease, starts getting worse after about 2-3 days.
Top 10 Doctor insights on: How Long Does Bullseye Rash Last. 1 Last year I was hiking and was bit multiple times by horseflies. 1 bite swelled very large on my foot and another had a bullseye looking rash. I've had many health issues since then that seem lyme disease related.