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You can take levothyroxine either one hour before meals or two hours after eating and one hour before taking other meds and any vitamins and supplements but two hours before taking iron or calcium. Source(s): I'm a nurse. Nope, your supposed to take it on an empty stomach, then eat an hour or so after you take it.
5 years ago. It is different for everyone how long the meds take to work. You should be scheduled for a blood test at about 6 - 8 weeks after starting levothyroxine. At that point your dosage may be adjusted, and then another blood test at 6 - 8 weeks.