certificate of analysis. Definition. A document issued by a regulatory or quality assurance entity verifying the adherence to product specifications and standards of production of certain products such as food products and drugs. The certificate usually includes the actual test results performed on the product batch.
Tay-Sachs disease is caused by a mutation in the HEXA gene located on chromosome 15. Tay-Sachs follows an autosomal recessive pattern of inheritance. With the help of the diagram, identify which of the offspring will be an unaffected carrier.
A rarer form of the disease known as Late-Onset Tay-Sachs exists, but this paper will focus on classic infantile TSD and explore its scientific and social implications. Definition and symptoms. TSD is defined as a genetic disorder that causes the progressive destruction of the central nervous system (2). TSD occurs in babies with the Tay-Sachs gene on chromosome 15 (1). All affected babies exhibit a red spot in the back of their eyes. TSD is caused by the absence of hexosaminidase A (Hex-A), an enzyme whose presence is necessary for the breaking down of acidic fatty materials known as gangliosides.