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1 Ghrelin is secreted by endocrine cells in the stomach, especially when one is hungry and. 2  acts on the hypothalamus to stimulate feeding. 3  This action counteracts the inhibition of feeding by leptin and PYY3-36. Ghrelin is secreted by endocrine cells in the stomach, especially when one is hungry and. 2  acts on the hypothalamus to stimulate feeding. 3  This action counteracts the inhibition of feeding by leptin and PYY3-36.
Ghrelin is a hormone that is produced by the stomach when it is empty. Ghrelin travels through the bloodstream to the brain where it stimulates neurons in the hypothalamus to signal hunger. But researchers now know that ghrelin has many other functions in the body.