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Tryptase (EC 3.4.21.59, ) is the most abundant secretory granule-derived serine proteinase contained in mast cells and has been used as a marker for mast cell activation.
Dr. Horwitz explained that plasma levels of tryptase are usually too low to measure in individuals who donât have mastocytosis or anaphylaxis. He said a better question is how to prevent mast cells from degranulating and releasing tryptase, as well as histamine and other chemicals that mediate allergic reactions.