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You can take levothyroxine either one hour before meals or two hours after eating and one hour before taking other meds and any vitamins and supplements but two hours before taking iron or calcium. Source(s): I'm a nurse. Nope, your supposed to take it on an empty stomach, then eat an hour or so after you take it.
Levothyroxine requires the same amount of monitoring as the brand-name products. However, your doctor may require one additional blood test eight to 12 weeks after starting generic levothyroxine. Your doctor will determine whether you will need to have additional blood tests.