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Effect of age on male fertility. While the effect of age on a man's fertility is not as significant as it is with women, there is a decline in the quality of sperm after the age of 45. After this age, it does tend to take longer for men to cause a pregnancy and the chance of having a baby with a health problem does slightly increase.
Medical Conditions. Medical conditions that can affect male fertility include any severe injury or major surgery, diabetes, HIV, thyroid disease, Cushing syndrome, heart attack, liver or kidney failure, and chronic anemia. Certain types of medications can impair sperm production. Infections in the Urinary Tract or Genitals.