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The onset of chemotherapy side effects depends on the chemotherapy and the individual. Sometimes side effects start within a day or 2 of starting chemotherapy and at other times they can start several days later. Being fine at the start is a good sign but it does not mean that the side effects will not start later.
The most common reaction is a skin rash. If you have been exposed to the drug before, the rash may start quickly, within the first day or two after taking the drug. The reaction also can be delayed and not occur until 8 to 10 days after starting the drug. It is even possible to develop the rash after you have finished a one week course of medication. When this does occur, it is usually related to an antibiotic.