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1 Insulin sensitivity is increased, so your cells are better able to use any available insulin to take up glucose during and after activity. 2  When your muscles contract during activity, it stimulates another mechanism that is completely separate of insulin.
Mechanism of Action. The primary activity of insulin, including insulin glargine, is regulation of glucose metabolism. Insulin and its analogs lower blood glucose levels by stimulating peripheral glucose uptake, especially by skeletal muscle and fat, and by inhibiting hepatic glucose production.