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The phi X 174 (or ÏX174) bacteriophage was the first DNA-based genome to be sequenced.This work was completed by Fred Sanger and his team in 1977. In 1962, Walter Fiers and Robert Sinsheimer had already demonstrated the physical, covalently closed circularity of ÏX174 DNA.n 2003, it was reported by Craig Venter's group that the genome of ÏX174 was the first to be completely assembled in vitro from synthesized oligonucleotides. The ÏX174 virus particle has also been successfully assembled in vitro.
Report Abuse. A bacteriophage (from 'bacteria' and Greek phagein, 'to eat') is a virus that infects bacteria. The term is commonly used in its shortened form, phage. Like viruses that infect eukaryotes (plants, animals and fungi), a large diversity of phage structures and functions exist.edit] Replication Bacteriophages may have a lytic cycle or a lysogenic cycle, however a few viruses are capable of carrying out both. In the lytic cycle, characteristic of virulent phages such as the T4 phage, host cells will be broken open (lysed) and suffer death after immediate replication of the virion.