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You can take levothyroxine either one hour before meals or two hours after eating and one hour before taking other meds and any vitamins and supplements but two hours before taking iron or calcium. Source(s): I'm a nurse. Nope, your supposed to take it on an empty stomach, then eat an hour or so after you take it.
If a child is using this medicine, tell your doctor if the child has any changes in weight. Levothyroxine doses are based on weight in children, and any changes may affect your child's dose. It may take several weeks before your body starts to respond to Synthroid. Keep using this medicine even if you feel well. You may need to use levothyroxine for the rest of your life. While using Synthroid, you may need frequent medical tests.