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Quadriceps weakness can be caused by various injuries to the knee or hips, acquired myopathies (diseases that affect muscle tissue) such as Lyme disease and poliomyelitis, inherited myopathies such as certain muscular dystrophies and stroke, or neurological diseases such as multiple sclerosis or Bellâs palsy.
Hereditary Spastic Paraplegia (HSP) is a group of rare, inherited neurological disorders. Their primary symptoms are progressive spasticity and weakness of the leg and hip muscles. Researchers estimate that some 30 different types of HSP exist; the genetic causes are known for eleven.SP can resemble cerebral palsy, however, HSP is degenerative and thereby causes increasing spasticity and weakness of the muscles. Two other disorders with spastic paraplegia symptoms termed Lathyrism and Konzo are caused by toxins in the plants Lathyrus sativus and cassava.