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Antibiotics will stay in your system fro 7 to 10 days.... Antibiotics will stay in your system fro 7 to 10 days. The actual time will depend upon the type of antibiotic taken, the dosage of the antibiotic taken and individual human body as well. Some antibiotics may stay for shorter durations than this also. jack perry.
replied March 30th, 2016. Most side effects of antibiotics do not last more than a few days (max 7 -10 days). If your issue is persistent for much longer duration, even after stopping the medications, then it is more likely that your symptoms are independent of the antibiotics. Consult your doctor and seek a second opinion.