In this reaction, all reactants and products are invisible. The heat being evolved is the clue that tells you a reaction is taking place. This is a good example of an exothermic reaction, a reaction in which heat is given off. A lot of reactions are exothermic.
Prothrombinase will cleave prothrombin to make thrombin and thrombin is the enzyme that cuts fibrinogen to make fibrin for clot formation [Blood Clotting: The Basics]. The platelet prothrombinase activity is the same as the activity on TP-bearing cells: itâs formed from Xa and membrane-bound Va.
The thrombin (prothrombin) gene is located on the eleventh chromosome (11p11-q12). There are an estimated 30 people in the world that have been diagnosed with the congenital form of Factor II deficiency, which should not be confused with the prothrombin G20210A mutation, which is also called the factor II mutation.