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Thick blood may also be caused by the presence of harmful pathogens such as fungi, viruses, bacteria, and parasites. These pathogens can actually activate a coagulation response in the body as a way to avoid being attacked by the bodyâs immune system.
1 In some cases of myeloma, excess protein in the blood can cause a condition called hyperviscosity syndrome. 2  The type and amount of immunoglobulin protein can result in thickening the blood beyond normal blood viscosity, which may result in alteration in a variety of bodily, including mental, processes.