As folate is vital in the first trimester of pregnancy for healthy fetal development, the use of antifolates is strongly contraindicated in pregnancy and carries significant teratogenic risk. Low doses of methotrexate can deplete folate stores and cause side-effects that are similar to folate deficiency.
Cause of Adult Mumps. Adult mumps is caused by an infection with the mumps virus, which is found worldwide. The mumps virus is an RNA (ribonucleic acid) virus from the family Paramyxovirus of the genus Rubulavirus. The mumps virus only infects humans.
Once the mumps virus enters the body, it passes into the bloodstream and can spread to many different glands and to the brain: Salivary glands â Mumps causes pain and swelling in the parotid gland and in other salivary glands located under the tongue and jaw. Testes â In the testes, mumps infection can cause swelling, pain, tenderness and, sometimes, permanent shrinkage (atrophy), although it rarely causes sterility.