In fact, degenerative arthritis is thought to involve the entire joint structure with erosion of articular cartilage, hypertrophy of bone at the margins of the affected joint, changes to the synovial membrane (i.e., joint lining), subchondral bone sclerosis, and involvement of the ligaments and periarticular muscles.
14 days: The bullseye rash of lyme disease takes about 14 days to show up. You could have an allergic reaction to a bug bite that will develop within a day. Infection from a bite, not lyme disease, starts getting worse after about 2-3 days.
1 Stage 1. 2  In the majority of cases, the first sign of early Lyme disease is the appearance of a bull's-eye skin rash. 3  It usually develops about 1 - 2 weeks after the bite, although it may appear as soon as 3 days, and as late as 1 month. 4  In some cases, it is never detected.he bull's eye rash, which is considered the classic sign of Lyme disease, may take the following course: 1  It can first appear as a pimple-like spot, which expands over the next few days into a purplish circle. 2  The circle may reach up to 6 inches in diameter with a deeper red rim.