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You can take levothyroxine either one hour before meals or two hours after eating and one hour before taking other meds and any vitamins and supplements but two hours before taking iron or calcium. Source(s): I'm a nurse. Nope, your supposed to take it on an empty stomach, then eat an hour or so after you take it.
Speak to your doctor if any of these foods are a regular part of your diet. Some medications or vitamins can also make thyroid medication less effective, including antacids, cholesterol-lowering drugs and calcium and iron supplements. These should be taken either four hours before or after taking levothyroxine.