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Tryptase (EC 3.4.21.59, ) is the most abundant secretory granule-derived serine proteinase contained in mast cells and has been used as a marker for mast cell activation.
The first challenge of suspected MCAS sufferers is to find a doctor who has the time and experience to assimilate a complicated medical history. Note that there is no one definitive test for MCAS. Tryptase is reported by many doctors in the published literature to be an unreliable marker for MCAS.