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RhoGAM is used for: Preventing certain blood problems that may occur during pregnancy or blood transfusion. It may also be used for other conditions as determined by your doctor. RhoGAM is an immunoglobulin (Ig), which contains antibodies to the Rho(D) antigen. Exactly how it works is unknown.
A RhoGAM shot will be administered to you no more than 72 hours after you deliver your baby, when his blood leaks into your bloodstream. This shot helps avert Rh factor incompatibility by preventing your immune system from developing antibodies that will fight against the Rh factor contained in your babyâs blood.