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Quadriceps weakness can be caused by various injuries to the knee or hips, acquired myopathies (diseases that affect muscle tissue) such as Lyme disease and poliomyelitis, inherited myopathies such as certain muscular dystrophies and stroke, or neurological diseases such as multiple sclerosis or Bellâs palsy.
Other factors that can put extra tension on your quadriceps and influence your risk of experiencing a quadriceps strain include: 1  Poor fitness levels and lack of exercise. 2  Poor nutrition and obesity. 3  Posture irregularities (lumbar lordosis) 4  Neural tension (scar tissue around the nerves)