certificate of analysis. Definition. A document issued by a regulatory or quality assurance entity verifying the adherence to product specifications and standards of production of certain products such as food products and drugs. The certificate usually includes the actual test results performed on the product batch.
Tay-Sachs disease is caused by a mutation in the HEXA gene located on chromosome 15. Tay-Sachs follows an autosomal recessive pattern of inheritance. With the help of the diagram, identify which of the offspring will be an unaffected carrier.
The classical form of Tay-Sachs disease occurs during infancy; an adult form (late-onset Tay-Sachs disease) may occur anytime from adolescence to the mid 30's. Tay-Sachs disease is inherited as an autosomal recessive trait. The disorder results from changes (mutations) of a gene known as the HEXA gene, which regulates production of the hexosaminidase A enzyme. The HEXA gene has been mapped to the long arm (q) of chromosome 15 (15q23-q24).