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Tryptase (EC 3.4.21.59, ) is the most abundant secretory granule-derived serine proteinase contained in mast cells and has been used as a marker for mast cell activation.
If systemic mastocytosis is suspected, an elevated tryptase test may be followed by a bone marrow aspiration and biopsy to determine if systemic mastocytosis is present. Typically, there are increased numbers of mast cells in the bone marrow in this disease.he tryptase test may be used: 1  To confirm a diagnosis of anaphylaxis. 2  Anaphylaxis is primarily diagnosed clinically, but a total tryptase may be ordered, along with a histamine test, to help confirm anaphylaxis as the cause of someone's acute symptoms.