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There is no benefit of blood testing for Lyme disease at the time of the tick bite; even people who become infected will not have a positive blood test until approximately two to six weeks after the infection develops (post-tick bite).he risk of acquiring Lyme disease from an observed tick bite, for example, is only 1.2 to 1.4 percent, even in an area where the disease is common. If a person is bitten by a deer tick (the type of tick that carries Lyme disease), a healthcare provider will likely advise one of two approaches:
Early Signs and Symptoms (3 to 30 days after tick bite) 1  Fever, chills, headache, fatigue, muscle and joint aches, and swollen lymph nodes. 2  Erythema migrans (EM) rash: Occurs in approximately 70 to 80 percent of infected persons. Begins at the site of a tick bite after a delay of 3 to 30 days (average is about 7 days) Expands gradually over a period of days reaching up to 12 inches or more (30 cm) across.