In fact, degenerative arthritis is thought to involve the entire joint structure with erosion of articular cartilage, hypertrophy of bone at the margins of the affected joint, changes to the synovial membrane (i.e., joint lining), subchondral bone sclerosis, and involvement of the ligaments and periarticular muscles.
14 days: The bullseye rash of lyme disease takes about 14 days to show up. You could have an allergic reaction to a bug bite that will develop within a day. Infection from a bite, not lyme disease, starts getting worse after about 2-3 days.
Two weeks? No red line - if one developes get to er, no bulls eye which usually forms w/in 1 - 72 hrs., not painful yet still hard & swollen.... did not mention if you had applied triple anti antibiotic cream or rubbing alcohol or hydrogen peroxide solution a few times daily, either way...