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Tryptase (EC 3.4.21.59, ) is the most abundant secretory granule-derived serine proteinase contained in mast cells and has been used as a marker for mast cell activation.
Mast cells can be classified by the presence or lack of tryptase and/or chymase. MC TC mast cells have granules that contain tryptase and chymase (found mainly in skin and intestinal submucosa) while MC T mast cells have granules containing only tryptase (found mainly in respiratory tissue and intestinal mucosa). They can also be classified by their location within the body.