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Tryptase (EC 3.4.21.59, ) is the most abundant secretory granule-derived serine proteinase contained in mast cells and has been used as a marker for mast cell activation.
The Role of Tryptase in Mast Cell Stabilization. Mast cells play a critical role in normal immune function and respond to antigen stimuli by releasing mediators such as histamine, leukotrienes, and tryptase. Histamine and leukotrienes are well known for their role in air-borne environmental exposure reactions. Tryptase (also commonly referred to as mast cell tryptase, mast cell protease II, mast cell neutral proteinase and tryptase M) is released in the same response.