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In iron deficiency, the iron level is low but the TIBC is increased, thus transferrin saturation becomes very low. In iron overload states, such as hemochromatosis, the iron level will be high and the TIBC will be low or normal, causing the transferrin saturation to increase. UIBC may be ordered as an alternative to TIBC.
Transferrin is the main protein in the blood that binds to iron and transports it throughout the body. Transferrin levels rise with iron deficiency and fall in cases of iron overload.Transferrin is also responsible for circadian variation in serum iron (which peaks in the AM).ormally, iron is absorbed from food and transported throughout the body by transferrin, which is produced by the liver. About 70% of the iron is transported to the bone marrow and incorporated into hemoglobin within red blood cells.