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Norco can be detected in the urine for 3-4 days. A blood test can identify Norco for up to 24 hours. A saliva test can detect Norco for up to 1-4 days. Norco, like many other drugs, can be detected with a hair follicle drug test for up to 90 days. Knowing how long Norco remains in the system and help prevent an accidental overdose by taking too much of the medication too soon.
The metabolism of oxycodone to oxymorphone is catalyzed by CYP2D6. Free and conjugated noroxycodone, free and conjugated oxycodone, and oxymorphone are excreted in human urine following a single oral dose of oxycodone. Approximately 8% to 14% of the dose is excreted as free oxycodone over 24 hours after administration. Following a single, oral dose of oxycodone, the mean Â± SD elimination half-life is 3.51 Â± 1.43 hours.