Spinal orexin A attenuates opioid-induced mechanical hypersensitivity in the rat
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully.  <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'Repeated administration of opioid analgesics for pain treatment canproduce paradoxical hyperalgesia via peripheral and/or central mechanisms. Thus,this study investigated whether spinally (centrally) administered orexin A attenuatesopioid-induced hyperalgesia (OIH).[D-Ala2, N-Me-Phe4, Gly5-ol]-enkephalin (DAMGO), a selective μ-opioidreceptor agonist, was used to induce mechanical hypersensitivity and was administeredintradermally (4 times, 1-hour intervals) on the rat hind paw dorsum. To determinewhether post- or pretreatments with spinal orexin A, dynorphin A, and antidynorphinA were effective in OIH, the drugs were injected through an intrathecalcatheter whose tip was positioned dorsally at the L3 segment of the spinal cord (5μg for all). Mechanical hypersensitivity was assessed using von Frey monofilaments' . Please return only a json list of at most 3 Keywords corresponding to the Description:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> {"Answer" : ["Analgesics, Opioid","Dynorphins","Enkephalin, Ala(2)-MePhe(4)-Gly(5)-","Hyperalgesia","Orexin Receptors","Orexins","Pain","Spinal Cord Dorsal Horn"]} <|eot_id|>
 Here is the Description of a dataset. Description:'Repeated administration of opioid analgesics for pain treatment canproduce paradoxical hyperalgesia via peripheral and/or central mechanisms. Thus,this study investigated whether spinally (centrally) administered orexin A attenuatesopioid-induced hyperalgesia (OIH).[D-Ala2, N-Me-Phe4, Gly5-ol]-enkephalin (DAMGO), a selective μ-opioidreceptor agonist, was used to induce mechanical hypersensitivity and was administeredintradermally (4 times, 1-hour intervals) on the rat hind paw dorsum. To determinewhether post- or pretreatments with spinal orexin A, dynorphin A, and antidynorphinA were effective in OIH, the drugs were injected through an intrathecalcatheter whose tip was positioned dorsally at the L3 segment of the spinal cord (5μg for all). Mechanical hypersensitivity was assessed using von Frey monofilaments' . Please return only a json list of at most 3 Keywords corresponding to the Description:.
Repeated administration of opioid analgesics for pain treatment canproduce paradoxical hyperalgesia via peripheral and/or central mechanisms. Thus,this study investigated whether spinally (centrally) administered orexin A attenuatesopioid-induced hyperalgesia (OIH).[D-Ala2, N-Me-Phe4, Gly5-ol]-enkephalin (DAMGO), a selective μ-opioidreceptor agonist, was used to induce mechanical hypersensitivity and was administeredintradermally (4 times, 1-hour intervals) on the rat hind paw dorsum. To determinewhether post- or pretreatments with spinal orexin A, dynorphin A, and antidynorphinA were effective in OIH, the drugs were injected through an intrathecalcatheter whose tip was positioned dorsally at the L3 segment of the spinal cord (5μg for all). Mechanical hypersensitivity was assessed using von Frey monofilaments
Analgesics, Opioid; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Hyperalgesia; Orexin Receptors; Orexins; Pain; Spinal Cord Dorsal Horn