Synergistic interaction between acetaminophen and L-carnosine improved neuropathic pain via NF-κB pathway and antioxidant properties in chronic constriction injury model
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully.  <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'Inflammation is known to underlie the pathogenesis in neuropathicpain. This study investigated the anti-inflammatory and neuroprotective mechanismsinvolved in antinociceptive effects of co-administration of acetaminophenand L-carnosine in chronic constriction injury (CCI)-induced peripheral neuropathy inmale Wistar rats.Fifty-six male Wistar rats were randomly divided into seven experimentalgroups (n = 8) treated with normal saline/acetaminophen/acetaminophen +L-carnosine. CCI was used to induce neuropathic pain in rats. Hyperalgesia and allodyniawere assessed using hotplate and von Frey tests, respectively. Investigationof spinal proinflammatory cytokines and antioxidant system were carried out aftertwenty-one days of treatment' . Please return only a json list of at most 3 Keywords corresponding to the Description:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> {"Answer" : ["Acetaminophen","Anti-Inflammatory Agents","Antioxidants","Carnosine","Cytokines","Hyperalgesia","Lipid Peroxidation","Neuralgia","NF-kappa B","Spinal Cord"]} <|eot_id|>
 Here is the Description of a dataset. Description:'Inflammation is known to underlie the pathogenesis in neuropathicpain. This study investigated the anti-inflammatory and neuroprotective mechanismsinvolved in antinociceptive effects of co-administration of acetaminophenand L-carnosine in chronic constriction injury (CCI)-induced peripheral neuropathy inmale Wistar rats.Fifty-six male Wistar rats were randomly divided into seven experimentalgroups (n = 8) treated with normal saline/acetaminophen/acetaminophen +L-carnosine. CCI was used to induce neuropathic pain in rats. Hyperalgesia and allodyniawere assessed using hotplate and von Frey tests, respectively. Investigationof spinal proinflammatory cytokines and antioxidant system were carried out aftertwenty-one days of treatment' . Please return only a json list of at most 3 Keywords corresponding to the Description:.
Inflammation is known to underlie the pathogenesis in neuropathicpain. This study investigated the anti-inflammatory and neuroprotective mechanismsinvolved in antinociceptive effects of co-administration of acetaminophenand L-carnosine in chronic constriction injury (CCI)-induced peripheral neuropathy inmale Wistar rats.Fifty-six male Wistar rats were randomly divided into seven experimentalgroups (n = 8) treated with normal saline/acetaminophen/acetaminophen +L-carnosine. CCI was used to induce neuropathic pain in rats. Hyperalgesia and allodyniawere assessed using hotplate and von Frey tests, respectively. Investigationof spinal proinflammatory cytokines and antioxidant system were carried out aftertwenty-one days of treatment
Acetaminophen; Anti-Inflammatory Agents; Antioxidants; Carnosine; Cytokines; Hyperalgesia; Lipid Peroxidation; Neuralgia; NF-kappa B; Spinal Cord