Penetration of topically administered corticosteroids in normal equine ocular fluids
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully.  <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'Background: Topical dexamethasone and prednisolone are currently the mainstay treatment for equine ophthalmic inflammatory diseases, such as equine recurrent uveitis. Comparative pharmacokinetic studies in horses are lacking and current guidelines are mainly based on empirical data and extrapolation from other species.Objectives: To investigate the penetration and local concentrations of topically applied dexamethasone and prednisolone in normal equine ocular fluids and serum.Study Design: Prospective randomized experimental pharmacokinetic study.  Methods: Twenty-one Shetland ponies without ophthalmic disease were treated bilaterally topically every 2 hours during 24 hours to obtain steady-state drug concentrations. One eye was treated with 0.15 mg dexamethasone disodium phosphate (0.1%) and the other eye was simultaneously treated ' . Please return only a json list of at most 3 Keywords corresponding to the Description:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> {"Answer" : ["corticosteroids","drug dosing interval","horse","liquid chromatography-mass spectrometry","ophthalmic","topical administration"]} <|eot_id|>
 Here is the Description of a dataset. Description:'Background: Topical dexamethasone and prednisolone are currently the mainstay treatment for equine ophthalmic inflammatory diseases, such as equine recurrent uveitis. Comparative pharmacokinetic studies in horses are lacking and current guidelines are mainly based on empirical data and extrapolation from other species.Objectives: To investigate the penetration and local concentrations of topically applied dexamethasone and prednisolone in normal equine ocular fluids and serum.Study Design: Prospective randomized experimental pharmacokinetic study.  Methods: Twenty-one Shetland ponies without ophthalmic disease were treated bilaterally topically every 2 hours during 24 hours to obtain steady-state drug concentrations. One eye was treated with 0.15 mg dexamethasone disodium phosphate (0.1%) and the other eye was simultaneously treated ' . Please return only a json list of at most 3 Keywords corresponding to the Description:.
Background: Topical dexamethasone and prednisolone are currently the mainstay treatment for equine ophthalmic inflammatory diseases, such as equine recurrent uveitis. Comparative pharmacokinetic studies in horses are lacking and current guidelines are mainly based on empirical data and extrapolation from other species.Objectives: To investigate the penetration and local concentrations of topically applied dexamethasone and prednisolone in normal equine ocular fluids and serum.Study Design: Prospective randomized experimental pharmacokinetic study.  Methods: Twenty-one Shetland ponies without ophthalmic disease were treated bilaterally topically every 2 hours during 24 hours to obtain steady-state drug concentrations. One eye was treated with 0.15 mg dexamethasone disodium phosphate (0.1%) and the other eye was simultaneously treated 
corticosteroids; drug dosing interval; horse; liquid chromatography-mass spectrometry; ophthalmic; topical administration