Khan 2020_Diminished sphingolipid metabolism, a hallmark of future type 2 diabetes pathogenesis, is linked to pancreatic beta-cell dysfunction
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully.  <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'Pancreatic beta-cell dysfunction and loss of mass are essential mechanisms for Type 2 diabetes (T2D) development. We present several pieces of evidence supporting the pivotal role of diminished sphingolipid metabolism in these mechanistic aspects of T2D; this is accomplished using an omics-derived precision medicine approach on a subset of gestational diabetes mellitus (GDM) women of the SWIFT cohort, coupled with subsequent system biology, in vivo and in vitro studies. We have also devised a mapping strategy for standalone metabolomics on genome-wide association study data, which has identified two sphingolipid metabolism-re¬¬lated genes (i.e., CERS2 and CERS4) with five risk-alleles for T2D development and overall biochemical phenotype. Furthermore, incorporating sphingolipid sphingomyelin (SM) C16:10 level was found to significantly ' . Please return only a json list of at most 3 Keywords corresponding to the Description:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> {"Answer" : ["GDM","T2D"]} <|eot_id|>
 Here is the Description of a dataset. Description:'Pancreatic beta-cell dysfunction and loss of mass are essential mechanisms for Type 2 diabetes (T2D) development. We present several pieces of evidence supporting the pivotal role of diminished sphingolipid metabolism in these mechanistic aspects of T2D; this is accomplished using an omics-derived precision medicine approach on a subset of gestational diabetes mellitus (GDM) women of the SWIFT cohort, coupled with subsequent system biology, in vivo and in vitro studies. We have also devised a mapping strategy for standalone metabolomics on genome-wide association study data, which has identified two sphingolipid metabolism-re¬¬lated genes (i.e., CERS2 and CERS4) with five risk-alleles for T2D development and overall biochemical phenotype. Furthermore, incorporating sphingolipid sphingomyelin (SM) C16:10 level was found to significantly ' . Please return only a json list of at most 3 Keywords corresponding to the Description:.
Pancreatic beta-cell dysfunction and loss of mass are essential mechanisms for Type 2 diabetes (T2D) development. We present several pieces of evidence supporting the pivotal role of diminished sphingolipid metabolism in these mechanistic aspects of T2D; this is accomplished using an omics-derived precision medicine approach on a subset of gestational diabetes mellitus (GDM) women of the SWIFT cohort, coupled with subsequent system biology, in vivo and in vitro studies. We have also devised a mapping strategy for standalone metabolomics on genome-wide association study data, which has identified two sphingolipid metabolism-re¬¬lated genes (i.e., CERS2 and CERS4) with five risk-alleles for T2D development and overall biochemical phenotype. Furthermore, incorporating sphingolipid sphingomyelin (SM) C16:10 level was found to significantly 
GDM; T2D