Safety and potential application of nanoparticles loaded with a trypsin inhibitor isolated from tamarind seeds (Tamarindus indica L.)
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully.  <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'The trypsin inhibitor isolated from tamarind seeds (TTI) presents satietogenic and anti-inflammatory effects. In the present study, TTI encapsulation by nanoprecipitation in purified chitosan and whey protein isolate (ECW) was performed to maintain TTI’s integrity and protection through the gastrointestinal tract.  The interaction between TTI and the encapsulating agents was determined by filtration (Amicon® 100 K) monitoring the antitrypsin activity. Cytotoxicity was evaluated in Caco-2 and CCD-18Co cells at different concentrations (0.5, 2.5 and 5.0 mg/mL). Subacute blood toxicity was evaluated in Wistar rats (12.5 mg/kg) for ten days. The particles presented a smooth surface, with 118 (17.27) nm of diameter, 0.37 (0.02) of polydispersity index, -38.26 (0.15) mV (neutral pH) of surface charge, and 95.3 (0.31) % of incorporation effici' . Please return only a json list of at most 3 Keywords corresponding to the Description:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> {"Answer" : ["Nanoparticle, antitrypsin activity, Wistar rats, cytotoxicity."]} <|eot_id|>
 Here is the Description of a dataset. Description:'The trypsin inhibitor isolated from tamarind seeds (TTI) presents satietogenic and anti-inflammatory effects. In the present study, TTI encapsulation by nanoprecipitation in purified chitosan and whey protein isolate (ECW) was performed to maintain TTI’s integrity and protection through the gastrointestinal tract.  The interaction between TTI and the encapsulating agents was determined by filtration (Amicon® 100 K) monitoring the antitrypsin activity. Cytotoxicity was evaluated in Caco-2 and CCD-18Co cells at different concentrations (0.5, 2.5 and 5.0 mg/mL). Subacute blood toxicity was evaluated in Wistar rats (12.5 mg/kg) for ten days. The particles presented a smooth surface, with 118 (17.27) nm of diameter, 0.37 (0.02) of polydispersity index, -38.26 (0.15) mV (neutral pH) of surface charge, and 95.3 (0.31) % of incorporation effici' . Please return only a json list of at most 3 Keywords corresponding to the Description:.
The trypsin inhibitor isolated from tamarind seeds (TTI) presents satietogenic and anti-inflammatory effects. In the present study, TTI encapsulation by nanoprecipitation in purified chitosan and whey protein isolate (ECW) was performed to maintain TTI’s integrity and protection through the gastrointestinal tract.  The interaction between TTI and the encapsulating agents was determined by filtration (Amicon® 100 K) monitoring the antitrypsin activity. Cytotoxicity was evaluated in Caco-2 and CCD-18Co cells at different concentrations (0.5, 2.5 and 5.0 mg/mL). Subacute blood toxicity was evaluated in Wistar rats (12.5 mg/kg) for ten days. The particles presented a smooth surface, with 118 (17.27) nm of diameter, 0.37 (0.02) of polydispersity index, -38.26 (0.15) mV (neutral pH) of surface charge, and 95.3 (0.31) % of incorporation effici
Nanoparticle, antitrypsin activity, Wistar rats, cytotoxicity.