Perioperative stress prolong post-surgical pain via miR-339-5p targeting oprm1 in the amygdala
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully.  <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'The decreased expression of mu-opioid receptors (MOR) in the amygdalamay be a key molecular in chronic post-surgical pain (CPSP). It is known thatmiR-339-5p expression in the amygdala of a stressed rat model was increased. Analyzed by RNAhybrid, miR-339-5p could target opioid receptor mu 1 (oprm1) whichcodes MOR directly. So, the authors hypothesized that miR-339-5p could regulatethe expression of MOR via targeting oprm1 and cause the effects to CPSP.To simulate perioperative short-term stress, a perioperative stress prolongsincision-induced pain hypersensitivity without changing basal pain perceptionrat model was built. A pmiR-RB-REPORT™ dual luciferase assay was taken to verifywhether miR-339-5p could act on oprm1 as a target. The serum glucocorticoid levelof rats was test. Differential expressions of MOR, GFAP, and pERK1/2 i' . Please return only a json list of at most 3 Keywords corresponding to the Description:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> {"Answer" : ["Amygdala","Glucocorticoids","MicroRNAs","Models, Animal","Pain Perception","Pain, Postoperative","Physiopathology","Receptors, Opioid, mu","Stress, Physiological"]} <|eot_id|>
 Here is the Description of a dataset. Description:'The decreased expression of mu-opioid receptors (MOR) in the amygdalamay be a key molecular in chronic post-surgical pain (CPSP). It is known thatmiR-339-5p expression in the amygdala of a stressed rat model was increased. Analyzed by RNAhybrid, miR-339-5p could target opioid receptor mu 1 (oprm1) whichcodes MOR directly. So, the authors hypothesized that miR-339-5p could regulatethe expression of MOR via targeting oprm1 and cause the effects to CPSP.To simulate perioperative short-term stress, a perioperative stress prolongsincision-induced pain hypersensitivity without changing basal pain perceptionrat model was built. A pmiR-RB-REPORT™ dual luciferase assay was taken to verifywhether miR-339-5p could act on oprm1 as a target. The serum glucocorticoid levelof rats was test. Differential expressions of MOR, GFAP, and pERK1/2 i' . Please return only a json list of at most 3 Keywords corresponding to the Description:.
The decreased expression of mu-opioid receptors (MOR) in the amygdalamay be a key molecular in chronic post-surgical pain (CPSP). It is known thatmiR-339-5p expression in the amygdala of a stressed rat model was increased. Analyzed by RNAhybrid, miR-339-5p could target opioid receptor mu 1 (oprm1) whichcodes MOR directly. So, the authors hypothesized that miR-339-5p could regulatethe expression of MOR via targeting oprm1 and cause the effects to CPSP.To simulate perioperative short-term stress, a perioperative stress prolongsincision-induced pain hypersensitivity without changing basal pain perceptionrat model was built. A pmiR-RB-REPORT™ dual luciferase assay was taken to verifywhether miR-339-5p could act on oprm1 as a target. The serum glucocorticoid levelof rats was test. Differential expressions of MOR, GFAP, and pERK1/2 i
Amygdala; Glucocorticoids; MicroRNAs; Models, Animal; Pain Perception; Pain, Postoperative; Physiopathology; Receptors, Opioid, mu; Stress, Physiological