Whole-genome sequencing reveals new Alzheimer’s disease-associated rare variants - Rudy Tanzi, Lars Bertram and Win Hide
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully.  <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'Here we report the results of a family-based whole-genome sequencing (WGS) rare-variant association study in 2,247 subjects from 605 multiplex Alzheimer's disease (AD) families, followed by replication analyses in an independent case-control cohort comprising of more than 1,650 individuals. Employing both single-variant and spatial clustering-based (“region-based”) testing, we identified 13 new AD candidate loci (4 from single-variant, 9 from spatial-clustering analyses) that yield consistent rare-variant signals in both discovery and replication cohorts' . Please return only a json list of at most 3 Keywords corresponding to the Description:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> {"Answer" : ["Alzheimer's disease","Whole-genome sequencing"]} <|eot_id|>
 Here is the Description of a dataset. Description:'Here we report the results of a family-based whole-genome sequencing (WGS) rare-variant association study in 2,247 subjects from 605 multiplex Alzheimer's disease (AD) families, followed by replication analyses in an independent case-control cohort comprising of more than 1,650 individuals. Employing both single-variant and spatial clustering-based (“region-based”) testing, we identified 13 new AD candidate loci (4 from single-variant, 9 from spatial-clustering analyses) that yield consistent rare-variant signals in both discovery and replication cohorts' . Please return only a json list of at most 3 Keywords corresponding to the Description:.
Here we report the results of a family-based whole-genome sequencing (WGS) rare-variant association study in 2,247 subjects from 605 multiplex Alzheimer's disease (AD) families, followed by replication analyses in an independent case-control cohort comprising of more than 1,650 individuals. Employing both single-variant and spatial clustering-based (“region-based”) testing, we identified 13 new AD candidate loci (4 from single-variant, 9 from spatial-clustering analyses) that yield consistent rare-variant signals in both discovery and replication cohorts
Alzheimer's disease; Whole-genome sequencing