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[ "Selegiline", "-", "induced", "postural", "hypotension", "in", "Parkinson", "'", "s", "disease", ":", "a", "longitudinal", "study", "on", "the", "effects", "of", "drug", "withdrawal", "." ]
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BC5CDR-0
[ "OBJECTIVES", ":", "The", "United", "Kingdom", "Parkinson", "'", "s", "Disease", "Research", "Group", "(", "UKPDRG", ")", "trial", "found", "an", "increased", "mortality", "in", "patients", "with", "Parkinson", "'", "s", "disease", "(", "PD", ")", "randomized", "to", "receive", "10", "mg", "selegiline", "per", "day", "and", "L", "-", "dopa", "compared", "with", "those", "taking", "L", "-", "dopa", "alone", "." ]
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BC5CDR-1
[ "CONCLUSION", ":", "This", "study", "confirms", "our", "previous", "finding", "that", "selegiline", "in", "combination", "with", "L", "-", "dopa", "is", "associated", "with", "selective", "orthostatic", "hypotension", "." ]
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BC5CDR-10
[ "High", "doses", "of", "vitamin", "D", "are", "known", "to", "cause", "calcification", "of", "the", "artery", "media", "in", "as", "little", "as", "3", "to", "4", "days", "." ]
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BC5CDR-100
[ "We", "then", "used", "hyperbaric", "oxygen", "at", "an", "absolute", "pressure", "of", "2", "atm", ",", "5", "days", "a", "week", "for", "8", "consecutive", "weeks", "." ]
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BC5CDR-1000
[ "The", "bleeding", "ceased", "completely", "by", "the", "end", "of", "treatment", "and", "the", "patient", "remained", "free", "of", "hematuria", "thereafter", "." ]
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BC5CDR-1001
[ "No", "side", "effect", "was", "noted", "during", "the", "course", "of", "therapy", "." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
BC5CDR-1002
[ "In", "future", ",", "this", "form", "of", "therapy", "can", "offer", "a", "safe", "alternative", "in", "the", "treatment", "of", "cyclophosphamide", "-", "induced", "hemorrhagic", "cystitis", "." ]
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BC5CDR-1003
[ "Acute", "psychosis", "due", "to", "treatment", "with", "phenytoin", "in", "a", "nonepileptic", "patient", "." ]
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BC5CDR-1004
[ "The", "development", "of", "psychosis", "related", "to", "antiepileptic", "drug", "treatment", "is", "usually", "attributed", "to", "the", "interaction", "between", "the", "epileptic", "brain", "substratum", "and", "the", "antiepileptic", "drugs", "." ]
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BC5CDR-1005
[ "The", "case", "of", "a", "nonepileptic", "patient", "who", "developed", "psychosis", "following", "phenytoin", "treatment", "for", "trigeminal", "neuralgia", "is", "described", "." ]
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BC5CDR-1006
[ "This", "case", "suggests", "that", "the", "psychotic", "symptoms", "that", "occur", "following", "phenytoin", "treatment", "in", "some", "epileptic", "patients", "may", "be", "the", "direct", "result", "of", "medication", ",", "unrelated", "to", "seizures", "." ]
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BC5CDR-1007
[ "Risks", "of", "the", "consumption", "of", "beverages", "containing", "quinine", "." ]
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BC5CDR-1008
[ "Although", "the", "United", "States", "Food", "and", "Drug", "Administration", "banned", "its", "use", "for", "nocturnal", "leg", "cramps", "due", "to", "lack", "of", "safety", "and", "efficacy", ",", "quinine", "is", "widely", "available", "in", "beverages", "including", "tonic", "water", "and", "bitter", "lemon", "." ]
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BC5CDR-1009
[ "High", "doses", "of", "the", "vitamin", "K", "antagonist", "Warfarin", "are", "also", "known", "to", "cause", "calcification", "of", "the", "artery", "media", ",", "but", "at", "treatment", "times", "of", "2", "weeks", "or", "longer", "yet", "not", "at", "1", "week", "." ]
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BC5CDR-101
[ "Numerous", "anecdotal", "reports", "suggest", "that", "products", "containing", "quinine", "may", "produce", "neurological", "complications", ",", "including", "confusion", ",", "altered", "mental", "status", ",", "seizures", ",", "and", "coma", ",", "particularly", "in", "older", "women", "." ]
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BC5CDR-1010
[ "Psychologists", "need", "to", "inquire", "about", "consumption", "of", "quinine", "-", "containing", "beverages", "as", "part", "of", "an", "evaluation", "process", "." ]
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BC5CDR-1011
[ "Transient", "platypnea", "-", "orthodeoxia", "-", "like", "syndrome", "induced", "by", "propafenone", "overdose", "in", "a", "young", "woman", "with", "Ebstein", "'", "s", "anomaly", "." ]
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BC5CDR-1012
[ "In", "this", "report", "we", "describe", "the", "case", "of", "a", "37", "-", "year", "-", "old", "white", "woman", "with", "Ebstein", "'", "s", "anomaly", ",", "who", "developed", "a", "rare", "syndrome", "called", "platypnea", "-", "orthodeoxia", ",", "characterized", "by", "massive", "right", "-", "to", "-", "left", "interatrial", "shunting", "with", "transient", "profound", "hypoxia", "and", "cyanosis", "." ]
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BC5CDR-1013
[ "This", "shunt", "of", "blood", "via", "a", "patent", "foramen", "ovale", "occurred", "in", "the", "presence", "of", "a", "normal", "pulmonary", "artery", "pressure", ",", "and", "was", "probably", "precipitated", "by", "a", "propafenone", "overdose", "." ]
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BC5CDR-1014
[ "This", "drug", "caused", "biventricular", "dysfunction", ",", "due", "to", "its", "negative", "inotropic", "effect", ",", "and", "hypotension", ",", "due", "to", "its", "peripheral", "vasodilatory", "effect", "." ]
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BC5CDR-1015
[ "These", "effects", "gave", "rise", "to", "an", "increase", "in", "the", "right", "atrial", "pressure", "and", "a", "decrease", "in", "the", "left", "one", "with", "a", "consequent", "stretching", "of", "the", "foramen", "ovale", "and", "the", "creation", "of", "massive", "right", "-", "to", "-", "left", "shunting", "." ]
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BC5CDR-1016
[ "In", "our", "case", "this", "interatrial", "shunt", "was", "very", "accurately", "detected", "at", "bubble", "contrast", "echocardiography", "." ]
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BC5CDR-1017
[ "Noxious", "chemical", "stimulation", "of", "rat", "facial", "mucosa", "increases", "intracranial", "blood", "flow", "through", "a", "trigemino", "-", "parasympathetic", "reflex", "-", "-", "an", "experimental", "model", "for", "vascular", "dysfunctions", "in", "cluster", "headache", "." ]
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BC5CDR-1018
[ "Cluster", "headache", "is", "characterized", "by", "typical", "autonomic", "dysfunctions", "including", "facial", "and", "intracranial", "vascular", "disturbances", "." ]
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BC5CDR-1019
[ "In", "the", "current", "study", ",", "we", "investigated", "the", "synergy", "between", "these", "2", "treatments", "and", "found", "that", "concurrent", "Warfarin", "administration", "dramatically", "increased", "the", "extent", "of", "calcification", "in", "the", "media", "of", "vitamin", "D", "-", "treated", "rats", "at", "3", "and", "4", "days", "." ]
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BC5CDR-102
[ "Both", "the", "trigeminal", "and", "the", "cranial", "parasympathetic", "systems", "may", "be", "involved", "in", "mediating", "these", "dysfunctions", "." ]
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BC5CDR-1020
[ "An", "experimental", "model", "was", "developed", "in", "the", "rat", "to", "measure", "changes", "in", "lacrimation", "and", "intracranial", "blood", "flow", "following", "noxious", "chemical", "stimulation", "of", "facial", "mucosa", "." ]
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BC5CDR-1021
[ "Blood", "flow", "was", "monitored", "in", "arteries", "of", "the", "exposed", "cranial", "dura", "mater", "and", "the", "parietal", "cortex", "using", "laser", "Doppler", "flowmetry", "." ]
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BC5CDR-1022
[ "Capsaicin", "(", "0", ".", "01", "-", "1", "mm", ")", "applied", "to", "oral", "or", "nasal", "mucosa", "induced", "increases", "in", "dural", "and", "cortical", "blood", "flow", "and", "provoked", "lacrimation", "." ]
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BC5CDR-1023
[ "These", "responses", "were", "blocked", "by", "systemic", "pre", "-", "administration", "of", "hexamethonium", "chloride", "(", "20", "mg", "/", "kg", ")", "." ]
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BC5CDR-1024
[ "The", "evoked", "increases", "in", "dural", "blood", "flow", "were", "also", "abolished", "by", "topical", "pre", "-", "administration", "of", "atropine", "(", "1", "mm", ")", "and", "[", "Lys1", ",", "Pro2", ",", "5", ",", "Arg3", ",", "4", ",", "Tyr6", "]", "-", "VIP", "(", "0", ".", "1", "mm", ")", ",", "a", "vasoactive", "intestinal", "polypeptide", "(", "VIP", ")", "antagonist", ",", "onto", "the", "exposed", "dura", "mater", "." ]
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BC5CDR-1025
[ "We", "conclude", "that", "noxious", "stimulation", "of", "facial", "mucosa", "increases", "intracranial", "blood", "flow", "and", "lacrimation", "via", "a", "trigemino", "-", "parasympathetic", "reflex", "." ]
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BC5CDR-1026
[ "The", "blood", "flow", "responses", "seem", "to", "be", "mediated", "by", "the", "release", "of", "acetylcholine", "and", "VIP", "within", "the", "meninges", "." ]
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BC5CDR-1027
[ "Similar", "mechanisms", "may", "be", "involved", "in", "the", "pathogenesis", "of", "cluster", "headache", "." ]
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BC5CDR-1028
[ "Organophosphate", "-", "induced", "convulsions", "and", "prevention", "of", "neuropathological", "damages", "." ]
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BC5CDR-1029
[ "There", "was", "a", "close", "parallel", "between", "the", "effect", "of", "vitamin", "D", "dose", "on", "artery", "calcification", "and", "the", "effect", "of", "vitamin", "D", "dose", "on", "the", "elevation", "of", "serum", "calcium", ",", "which", "suggests", "that", "vitamin", "D", "may", "induce", "artery", "calcification", "through", "its", "effect", "on", "serum", "calcium", "." ]
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BC5CDR-103
[ "Such", "organophosphorus", "(", "OP", ")", "compounds", "as", "diisopropylfluorophosphate", "(", "DFP", ")", ",", "sarin", "and", "soman", "are", "potent", "inhibitors", "of", "acetylcholinesterases", "(", "AChEs", ")", "and", "butyrylcholinesterases", "(", "BChEs", ")", "." ]
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BC5CDR-1030
[ "The", "acute", "toxicity", "of", "OPs", "is", "the", "result", "of", "their", "irreversible", "binding", "with", "AChEs", "in", "the", "central", "nervous", "system", "(", "CNS", ")", ",", "which", "elevates", "acetylcholine", "(", "ACh", ")", "levels", "." ]
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BC5CDR-1031
[ "The", "protective", "action", "of", "subcutaneously", "(", "SC", ")", "administered", "antidotes", "or", "their", "combinations", "in", "DFP", "(", "2", ".", "0", "mg", "/", "kg", "BW", ")", "intoxication", "was", "studied", "in", "9", "-", "10", "-", "weeks", "-", "old", "Han", "-", "Wistar", "male", "rats", "." ]
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BC5CDR-1032
[ "The", "rats", "received", "AChE", "reactivator", "pralidoxime", "-", "2", "-", "chloride", "(", "2PAM", ")", "(", "30", ".", "0", "mg", "/", "kg", "BW", ")", ",", "anticonvulsant", "diazepam", "(", "2", ".", "0", "mg", "/", "kg", "BW", ")", ",", "A", "(", "1", ")", "-", "adenosine", "receptor", "agonist", "N", "(", "6", ")", "-", "cyclopentyl", "adenosine", "(", "CPA", ")", "(", "2", ".", "0", "mg", "/", "kg", "BW", ")", ",", "NMDA", "-", "receptor", "antagonist", "dizocilpine", "maleate", "(", "+", "-", "MK801", "hydrogen", "maleate", ")", "(", "2", ".", "0", "mg", "/", "kg", "BW", ")", "or", "their", "combinations", "with", "cholinolytic", "drug", "atropine", "sulfate", "(", "50", ".", "0", "mg", "/", "kg", "BW", ")", "immediately", "or", "30", "min", "after", "the", "single", "SC", "injection", "of", "DFP", "." ]
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BC5CDR-1033
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BC5CDR-1034
[ "All", "rats", "were", "terminated", "either", "24", "h", "or", "3", "weeks", "after", "the", "DFP", "injection", "." ]
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BC5CDR-1035
[ "The", "rats", "treated", "with", "DFP", "-", "atropine", "showed", "severe", "typical", "OP", "-", "induced", "toxicity", "signs", "." ]
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BC5CDR-1036
[ "When", "CPA", ",", "diazepam", "or", "2PAM", "was", "given", "immediately", "after", "DFP", "-", "atropine", ",", "these", "treatments", "prevented", ",", "delayed", "or", "shortened", "the", "occurrence", "of", "serious", "signs", "of", "poisoning", "." ]
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BC5CDR-1037
[ "Atropine", "-", "MK801", "did", "not", "offer", "any", "additional", "protection", "against", "DFP", "toxicity", "." ]
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BC5CDR-1038
[ "In", "conclusion", ",", "CPA", ",", "diazepam", "and", "2PAM", "in", "combination", "with", "atropine", "prevented", "the", "occurrence", "of", "serious", "signs", "of", "poisoning", "and", "thus", "reduced", "the", "toxicity", "of", "DFP", "in", "rat", "." ]
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BC5CDR-1039
[ "Because", "Warfarin", "treatment", "had", "no", "effect", "on", "the", "elevation", "in", "serum", "calcium", "produced", "by", "vitamin", "D", ",", "the", "synergy", "between", "Warfarin", "and", "vitamin", "D", "is", "probably", "best", "explained", "by", "the", "hypothesis", "that", "Warfarin", "inhibits", "the", "activity", "of", "matrix", "Gla", "protein", "as", "a", "calcification", "inhibitor", "." ]
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BC5CDR-104
[ "A", "pyridoxine", "-", "dependent", "behavioral", "disorder", "unmasked", "by", "isoniazid", "." ]
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BC5CDR-1040
[ "A", "3", "-", "year", "-", "old", "girl", "had", "behavioral", "deterioration", ",", "with", "hyperkinesis", ",", "irritability", ",", "and", "sleeping", "difficulties", "after", "the", "therapeutic", "administration", "of", "isoniazid", "." ]
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BC5CDR-1041
[ "The", "administration", "of", "pharmacologic", "doses", "of", "pyridoxine", "hydrochloride", "led", "to", "a", "disappearance", "of", "symptoms", "." ]
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BC5CDR-1042
[ "After", "discontinuing", "isoniazid", "therapy", "a", "similar", "pattern", "of", "behavior", "was", "noted", "that", "was", "controlled", "by", "pyridoxine", "." ]
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BC5CDR-1043
[ "A", "placebo", "had", "no", "effect", ",", "but", "niacinamide", "was", "as", "effective", "as", "pyridoxine", "." ]
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BC5CDR-1044
[ "Periodic", "withdrawal", "of", "pyridoxine", "was", "associated", "with", "return", "of", "the", "hyperkinesis", "." ]
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BC5CDR-1045
[ "The", "level", "of", "pyridoxal", "in", "the", "blood", "was", "normal", "during", "the", "periods", "of", "relapse", "." ]
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BC5CDR-1046
[ "Metabolic", "studies", "suggested", "a", "block", "in", "the", "kynurenine", "pathway", "of", "tryptophan", "metabolism", "." ]
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BC5CDR-1047
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BC5CDR-1048
[ "Recurrent", "excitation", "in", "the", "dentate", "gyrus", "of", "a", "murine", "model", "of", "temporal", "lobe", "epilepsy", "." ]
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BC5CDR-1049
[ "High", "levels", "of", "matrix", "Gla", "protein", "are", "found", "at", "sites", "of", "artery", "calcification", "in", "rats", "treated", "with", "vitamin", "D", "plus", "Warfarin", ",", "and", "chemical", "analysis", "showed", "that", "the", "protein", "that", "accumulated", "was", "indeed", "not", "gamma", "-", "carboxylated", "." ]
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BC5CDR-105
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BC5CDR-1050
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BC5CDR-1051
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BC5CDR-1052
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BC5CDR-1053
[ "Focal", "glutamate", "photostimulation", "of", "the", "granule", "cell", "layer", "at", "sites", "distant", "from", "the", "recording", "pipette", "resulted", "in", "population", "responses", "of", "1", "-", "30", "s", "duration", "in", "slices", "from", "SE", "survivors", "but", "not", "other", "groups", "." ]
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BC5CDR-1054
[ "These", "data", "support", "the", "hypothesis", "that", "SE", "-", "induced", "mossy", "fiber", "sprouting", "and", "synaptic", "reorganization", "are", "relevant", "characteristics", "of", "seizure", "development", "in", "these", "murine", "strains", ",", "resembling", "rat", "models", "of", "human", "temporal", "lobe", "epilepsy", "." ]
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BC5CDR-1055
[ "Urinary", "bladder", "cancer", "in", "Wegener", "'", "s", "granulomatosis", ":", "risks", "and", "relation", "to", "cyclophosphamide", "." ]
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BC5CDR-1056
[ "OBJECTIVE", ":", "To", "assess", "and", "characterise", "the", "risk", "of", "bladder", "cancer", ",", "and", "its", "relation", "to", "cyclophosphamide", ",", "in", "patients", "with", "Wegener", "'", "s", "granulomatosis", "." ]
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BC5CDR-1057
[ "METHODS", ":", "In", "the", "population", "based", ",", "nationwide", "Swedish", "Inpatient", "Register", "a", "cohort", "of", "1065", "patients", "with", "Wegener", "'", "s", "granulomatosis", ",", "1969", "-", "95", ",", "was", "identified", "." ]
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BC5CDR-1058
[ "Through", "linkage", "with", "the", "Swedish", "Cancer", "Register", ",", "all", "subjects", "in", "this", "cohort", "diagnosed", "with", "bladder", "cancer", "were", "identified", "." ]
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BC5CDR-1059
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BC5CDR-106
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BC5CDR-1060
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BC5CDR-1061
[ "RESULTS", ":", "The", "median", "cumulative", "doses", "of", "cyclophosphamide", "among", "cases", "(", "n", "=", "11", ")", "and", "controls", "(", "n", "=", "25", ")", "were", "113", "g", "and", "25", "g", ",", "respectively", "." ]
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BC5CDR-1062
[ "The", "risk", "of", "bladder", "cancer", "doubled", "for", "every", "10", "g", "increment", "in", "cyclophosphamide", "(", "OR", "=", "2", ".", "0", ",", "95", "%", "confidence", "interval", "(", "CI", ")", "0", ".", "8", "to", "4", ".", "9", ")", "." ]
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BC5CDR-1063
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BC5CDR-1064
[ "The", "absolute", "risk", "for", "bladder", "cancer", "in", "the", "cohort", "reached", "10", "%", "16", "years", "after", "diagnosis", "of", "Wegener", "'", "s", "granulomatosis", ",", "and", "a", "history", "of", "bladder", "cancer", "was", "(", "non", "-", "significantly", ")", "twice", "as", "common", "as", "expected", "at", "the", "time", "of", "diagnosis", "of", "Wegener", "'", "s", "granulomatosis", "." ]
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BC5CDR-1065
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BC5CDR-1066
[ "Differential", "modulation", "by", "estrogen", "of", "alpha2", "-", "adrenergic", "and", "I1", "-", "imidazoline", "receptor", "-", "mediated", "hypotension", "in", "female", "rats", "." ]
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BC5CDR-1067
[ "We", "have", "recently", "shown", "that", "estrogen", "negatively", "modulates", "the", "hypotensive", "effect", "of", "clonidine", "(", "mixed", "alpha2", "-", "/", "I1", "-", "receptor", "agonist", ")", "in", "female", "rats", "and", "implicates", "the", "cardiovascular", "autonomic", "control", "in", "this", "interaction", "." ]
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BC5CDR-1068
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BC5CDR-1069
[ "Test", "conditions", "influence", "the", "response", "to", "a", "drug", "challenge", "in", "rodents", "." ]
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BC5CDR-107
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BC5CDR-1070
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BC5CDR-1071
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BC5CDR-1072
[ "SDRR", "was", "reduced", "only", "by", "alpha", "-", "methyldopa", "." ]
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BC5CDR-1073
[ "Ovx", "significantly", "enhanced", "the", "hypotensive", "response", "to", "alpha", "-", "methyldopa", ",", "in", "contrast", "to", "no", "effect", "on", "rilmenidine", "hypotension", "." ]
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BC5CDR-1074
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BC5CDR-1075
[ "Estrogen", "replacement", "(", "17beta", "-", "estradiol", "subcutaneous", "pellet", ",", "14", ".", "2", "microg", "/", "day", ",", "12", "wk", ")", "of", "Ovx", "rats", "restored", "the", "hemodynamic", "and", "locomotor", "effects", "of", "alpha", "-", "methyldopa", "to", "sham", "-", "operated", "levels", "." ]
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BC5CDR-1076
[ "These", "findings", "suggest", "that", "estrogen", "downregulates", "alpha2", "-", "but", "not", "I1", "-", "receptor", "-", "mediated", "hypotension", "and", "highlight", "a", "role", "for", "the", "cardiac", "autonomic", "control", "in", "alpha", "-", "methyldopa", "-", "estrogen", "interaction", "." ]
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BC5CDR-1077
[ "Severe", "reversible", "left", "ventricular", "systolic", "and", "diastolic", "dysfunction", "due", "to", "accidental", "iatrogenic", "epinephrine", "overdose", "." ]
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BC5CDR-1078
[ "Catecholamine", "-", "induced", "cardiomyopathy", "due", "to", "chronic", "excess", "of", "endogenous", "catecholamines", "has", "been", "recognized", "for", "decades", "as", "a", "clinical", "phenomenon", "." ]
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BC5CDR-1079
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BC5CDR-108
[ "In", "contrast", ",", "reports", "of", "myocardial", "dysfunction", "due", "to", "acute", "iatrogenic", "overdose", "are", "rare", "." ]
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BC5CDR-1080
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BC5CDR-1081
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BC5CDR-1082
[ "Cardioprotective", "effect", "of", "tincture", "of", "Crataegus", "on", "isoproterenol", "-", "induced", "myocardial", "infarction", "in", "rats", "." ]
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BC5CDR-1083
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BC5CDR-1084
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BC5CDR-1085
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BC5CDR-1086
[ "TCR", "prevented", "the", "isoproterenol", "-", "induced", "decrease", "in", "antioxidant", "enzymes", "in", "the", "heart", "and", "increased", "the", "rate", "of", "ADP", "-", "stimulated", "oxygen", "uptake", "and", "respiratory", "coupling", "ratio", "." ]
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BC5CDR-1087
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