Frameworks for black-box optimization
I am working on a project that requires to optimize several long time running QSAR models (for quantitative prediction of  drugs permeability and absorption). Considering that  the models are working in progress and changed frecuently, is not factible to hard-coding them so I was wondering to use a black-box optimization method. 

My question is, what frameworks for black-box optimization did you know?
 
Has anyone had experiences about the performance and flexibility of using  Pybrain for black-box optimization?

Any help or ideas? Thanks.
Frameworks for black-box optimization
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I am working on a project that requires to optimize several long time running QSAR models (for quantitative prediction of  drugs permeability and absorption). Considering that  the models are working in progress and changed frecuently, is not factible to hard-coding them so I was wondering to use a black-box optimization method. 

My question is, what frameworks for black-box optimization did you know?
 
Has anyone had experiences about the performance and flexibility of using  Pybrain for black-box optimization?

Any help or ideas? Thanks.