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156. Chen Y., Yang C., Wu Y., Mo S., Wang S., Yang G., Mei Z. Glycosmisines A and B: Isolation of two new carbazole-indole-type dimeric alkaloids from Glycosmis pentaphylla and an evaluation of their antiproliferative activities. Org. Biomol. Chem. 2005;13:6773–6781. doi: 10.1039/C5OB00695C. [ PubMed] [ <anchor>CrossRef</anchor>] [ Google Scholar]
Glycosmisines A and B: isolation of two new carbazole–indole-type dimeric alkaloids from Glycosmis pentaphylla and an evaluation of their antiproliferative activities - Organic & Biomolecular Chemistry (RSC Publishing)
Glycosmisines A and B: isolation of two new carbazole–indole-type dimeric alkaloids from Glycosmis pentaphylla and an evaluation of their antiproliferative activities - Organic & Biomolecular Chemistry (RSC Publishing)



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[Issue 24, 2015](/en/journals/journal/ob?issueid=ob013024&type=current&issnprint=1477-0520 "Issue 24, 2015")

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## Glycosmisines A and B: isolation of two new carbazole–indole-type dimeric alkaloids from _Glycosmis pentaphylla_ and an evaluation of their antiproliferative activities [†](\#fn1 "Electronic supplementary information (ESI) available. See DOI: 10.1039/c5ob00695c")

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[Yu\
Chen](/en/results?searchtext=Author%3AYu%20Chen),_a_[Chu\
Tang](/en/results?searchtext=Author%3AChu%20Tang),_b_[Yi\
Wu](/en/results?searchtext=Author%3AYi%20Wu),_b_[Shasha\
Mo](/en/results?searchtext=Author%3AShasha%20Mo),_b_[Sha\
Wang](/en/results?searchtext=Author%3ASha%20Wang),_b_[Guangzhong\
Yang](/en/results?searchtext=Author%3AGuangzhong%20Yang)\*_b_
and
[Zhinan\
Mei](/en/results?searchtext=Author%3AZhinan%20Mei)\*_b_

Author affiliations


\\*
Corresponding authors



a
College of Chemistry and Materials Sciences, South Central University for Nationalities, 182 Minyuan Road, Wuhan 430074, P. R. China



b
College of Pharmacy, South Central University for Nationalities, 708 Minyuan Road, Wuhan 430074, P. R. China



**E-mail:** [yanggz888@126.com](mailto:yanggz888@126.com "yanggz888@126.com"), [meizhinan@163.com](mailto:meizhinan@163.com "meizhinan@163.com")

### Abstract

Two unique carbazole–indole-type dimeric alkaloids, glycosmisines A ( **1**) and B ( **2**), have been isolated from the stems of _Glycosmis pentaphylla_ and their structures are elucidated by 1D and 2D NMR analyses, and their cytotoxicity against the growth of three cancer cell lines (A549, HepG-2 and Huh-7 cells) in culture was investigated using an MTT assay. Compounds **1** and **2** exhibited significant levels of cytotoxicity against three human cancer cell lines, and these two compounds also induced apoptosis in the same cell lines, as evidenced by changes in the morphological features of cells treated with these compounds and their dose-dependent accumulation of a sub-G1 population.

![Graphical abstract: Glycosmisines A and B: isolation of two new carbazole–indole-type dimeric alkaloids from Glycosmis pentaphylla and an evaluation of their antiproliferative activities](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C5OB00695C&imageInfo.ImageIdentifier.Year=2015)

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## Supplementary files

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## Article information

DOI[https://doi.org/10.1039/C5OB00695C](https://doi.org/10.1039/C5OB00695C "Link to landing page via DOI")

**Article type**Paper

Submitted08 Apr 2015

Accepted12 May 2015

First published14 May 2015

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_**Org. Biomol. Chem.**_, 2015, **13**, 6773-6781


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### Glycosmisines A and B: isolation of two new carbazole–indole-type dimeric alkaloids from _Glycosmis pentaphylla_ and an evaluation of their antiproliferative activities

Y. Chen, C. Tang, Y. Wu, S. Mo, S. Wang, G. Yang and Z. Mei,
_Org. Biomol. Chem._, 2015, **13**, 6773

**DOI:** 10.1039/C5OB00695C

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