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1409603	Other	Inhibition of SARS-CoV-2 pseudoparticle entry in human lung Airway Chip at reported drug Cmax, assessed by qRT-PCR after 48 hrs	Inhibition of SARS-CoV-2 pseudoparticle entry in human lung Airway Chip at reported drug Cmax, assessed by qRT-PCR after 48 hrs	Target ChEMBL ID: CHEMBL4303835_\|\|_ChEMBL Target Name: SARS-CoV-2_\|\|_ChEMBL Target Type: ORGANISM - Target is a complete organism_\|\|_Relationship Type: N - Non-molecular target assigned_\|\|_Confidence: Target assigned is non-molecular_\|\|_Data Source: SARS-CoV-2 Screening Data 2020-21	43	ChEMBL	CHEMBL4303817	20200619	20200619	2157\|2165\|2520\|2719\|2800\|131411\|3005573	103169732\|103188875\|103190631\|103628891\|104234145\|104240781\|242568127	null	null	null	Curation Efforts\|Research and Development	null	null	null	9606\|2697049	null	2697049	7	null	115	Lung epithelium	COVID-19\|COVID19\|Coronavirus\|Corona-virus\|SARS\|SARS2\|SARS-CoV\|SARS-CoV-2\|COVID info from ChEMBL
1409607	Confirmatory	IC50 for antiviral activity against SARS-CoV-2 in the Vero E6 cell line at 48 h by immunofluorescence-based assay (detecting the viral NP protein in the nucleus of the Vero E6 cells).	Title: A SARS-CoV-2 protein interaction map reveals targets for drug repurposing_\|\|_Abstract: The novel coronavirus SARS-CoV-2, the causative agent of COVID-19 respiratory disease, has infected over 2.3 million people, killed over 160,000, and caused worldwide social and economic disruption1,2. There are currently no antiviral drugs with proven clinical efficacy, nor are there vaccines for its prevention, and these efforts are hampered by limited knowledge of the molecular details of SARS-CoV-2 infection. To address this, we cloned, tagged and expressed 26 of the 29 SARS-CoV-2 proteins in human cells and identified the human proteins physically associated with each using affinity-purification mass spectrometry (AP-MS), identifying 332 high-confidence SARS-CoV-2-human protein-protein interactions (PPIs). Among these, we identify 66 druggable human proteins or host factors targeted by 69 compounds (29 FDA-approved drugs, 12 drugs in clinical trials, and 28 preclinical compounds). Screening a subset of these in multiple viral assays identified two sets of pharmacological agents that displayed antiviral activity: inhibitors of mRNA translation and predicted regulators of the Sigma1 and Sigma2 receptors. Further studies of these host factor targeting agents, including their combination with drugs that directly target viral enzymes, could lead to a therapeutic regimen to treat COVID-19.	Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation._\|\|_Journal: Nature_\|\|_Year: 2020_\|\|_DOI: 10.1038/s41586-020-2286-9_\|\|_Target ChEMBL ID: CHEMBL4303835_\|\|_ChEMBL Target Name: SARS-CoV-2_\|\|_ChEMBL Target Type: ORGANISM - Target is a complete organism_\|\|_Relationship Type: N - Non-molecular target assigned_\|\|_Confidence: Target assigned is non-molecular_\|\|_Data Source: SARS-CoV-2 Screening Data 2020-21	43	ChEMBL	CHEMBL4303083	20200619	20220830	2536\|2805\|3121\|3559\|3652\|3715\|3957\|4091\|4413\|4829\|16362\|26987\|30323\|37542\|41684\|44093\|53232\|53389\|446727\|447043\|676352\|5280343\|5284616\|5360696\|5362119\|5478883\|6911989\|6918328\|9817231\|9829523\|10113978\|10474335\|11955716\|16195554\|16726095\|24748573\|25126798\|44247568\|45375953\|46907787\|49830258\|57389999\|71549093\|73051434\|86271238\|118598754\|121427831\|122201421\|126961335\|129138801\|132010322\|135398745\|135539077\|135564749\|146047983\|146047984\|146047985	103163840\|103164548\|103167027\|103167216\|103170416\|103172458\|103173857\|103175236\|103177883\|103181943\|103195217\|103202903\|103234890\|103237360\|103266319\|103378026\|103477782\|103479736\|103503415\|103508547\|103511073\|103555944\|103556527\|103562286\|103566848\|103581295\|103605085\|103619997\|103623548\|103724215\|103734272\|104241012\|104246358\|123097007\|131281803\|134449640\|134461021\|136942413\|163334751\|174496643\|242402456\|312467947\|336874558\|336889861\|336891650\|381851019\|381854209\|381877252\|404668490\|404679228\|404718853\|405270161\|405270162\|405270164\|405270165\|405270170\|405270590	null	null	null	Curation Efforts\|Research and Development	32353859	null	null	60711\|2697049	546	2697049	57	16	null	null	COVID-19\|COVID19\|Coronavirus\|Corona-virus\|SARS\|SARS2\|SARS-CoV\|SARS-CoV-2\|COVID info from ChEMBL
1409608	Other	AUC (viral infection %) for SARS-CoV-2 in the Vero E6 cell line at 48 h by immunofluorescence-based assay (detecting the viral NP protein in the nucleus of the Vero E6 cells).	Title: A SARS-CoV-2 protein interaction map reveals targets for drug repurposing_\|\|_Abstract: The novel coronavirus SARS-CoV-2, the causative agent of COVID-19 respiratory disease, has infected over 2.3 million people, killed over 160,000, and caused worldwide social and economic disruption1,2. There are currently no antiviral drugs with proven clinical efficacy, nor are there vaccines for its prevention, and these efforts are hampered by limited knowledge of the molecular details of SARS-CoV-2 infection. To address this, we cloned, tagged and expressed 26 of the 29 SARS-CoV-2 proteins in human cells and identified the human proteins physically associated with each using affinity-purification mass spectrometry (AP-MS), identifying 332 high-confidence SARS-CoV-2-human protein-protein interactions (PPIs). Among these, we identify 66 druggable human proteins or host factors targeted by 69 compounds (29 FDA-approved drugs, 12 drugs in clinical trials, and 28 preclinical compounds). Screening a subset of these in multiple viral assays identified two sets of pharmacological agents that displayed antiviral activity: inhibitors of mRNA translation and predicted regulators of the Sigma1 and Sigma2 receptors. Further studies of these host factor targeting agents, including their combination with drugs that directly target viral enzymes, could lead to a therapeutic regimen to treat COVID-19.	Journal: Nature_\|\|_Year: 2020_\|\|_DOI: 10.1038/s41586-020-2286-9_\|\|_Target ChEMBL ID: CHEMBL4303835_\|\|_ChEMBL Target Name: SARS-CoV-2_\|\|_ChEMBL Target Type: ORGANISM - Target is a complete organism_\|\|_Relationship Type: N - Non-molecular target assigned_\|\|_Confidence: Target assigned is non-molecular_\|\|_Data Source: SARS-CoV-2 Screening Data 2020-21	43	ChEMBL	CHEMBL4303085	20200619	20230629	2536\|2805\|3121\|3559\|3652\|3715\|3957\|4091\|4413\|4829\|16362\|26987\|30323\|37542\|41684\|44093\|53232\|53389\|446727\|447043\|676352\|5280343\|5284616\|5360696\|5362119\|5478883\|6911989\|6918328\|9817231\|9829523\|10113978\|10474335\|11955716\|16195554\|16726095\|24748573\|25126798\|44247568\|45375953\|46907787\|49830258\|57389999\|71549093\|73051434\|86271238\|118598754\|121427831\|122201421\|126961335\|129138801\|132010322\|135398745\|135539077\|135564749\|146047983\|146047984\|146047985	103163840\|103164548\|103167027\|103167216\|103170416\|103172458\|103173857\|103175236\|103177883\|103181943\|103195217\|103202903\|103234890\|103237360\|103266319\|103378026\|103477782\|103479736\|103503415\|103508547\|103511073\|103555944\|103556527\|103562286\|103566848\|103581295\|103605085\|103619997\|103623548\|103724215\|103734272\|104241012\|104246358\|123097007\|131281803\|134449640\|134461021\|136942413\|163334751\|174496643\|242402456\|312467947\|336874558\|336889861\|336891650\|381851019\|381854209\|381877252\|404668490\|404679228\|404718853\|405270161\|405270162\|405270164\|405270165\|405270170\|405270590	null	null	null	Curation Efforts\|Research and Development	32353859	null	null	60711\|2697049	546	2697049	57	null	null	null	COVID-19\|COVID19\|Coronavirus\|Corona-virus\|SARS\|SARS2\|SARS-CoV\|SARS-CoV-2\|COVID info from ChEMBL
1409613	Other	Selectivity ratio: ratio of AUC (viral infection %) of SARS-CoV-2 in the Vero E6 cell line compared to AUC (cytotoxicity %) of compound against Vero E6 cells by MTT assay.	Title: A SARS-CoV-2 protein interaction map reveals targets for drug repurposing_\|\|_Abstract: The novel coronavirus SARS-CoV-2, the causative agent of COVID-19 respiratory disease, has infected over 2.3 million people, killed over 160,000, and caused worldwide social and economic disruption1,2. There are currently no antiviral drugs with proven clinical efficacy, nor are there vaccines for its prevention, and these efforts are hampered by limited knowledge of the molecular details of SARS-CoV-2 infection. To address this, we cloned, tagged and expressed 26 of the 29 SARS-CoV-2 proteins in human cells and identified the human proteins physically associated with each using affinity-purification mass spectrometry (AP-MS), identifying 332 high-confidence SARS-CoV-2-human protein-protein interactions (PPIs). Among these, we identify 66 druggable human proteins or host factors targeted by 69 compounds (29 FDA-approved drugs, 12 drugs in clinical trials, and 28 preclinical compounds). Screening a subset of these in multiple viral assays identified two sets of pharmacological agents that displayed antiviral activity: inhibitors of mRNA translation and predicted regulators of the Sigma1 and Sigma2 receptors. Further studies of these host factor targeting agents, including their combination with drugs that directly target viral enzymes, could lead to a therapeutic regimen to treat COVID-19.	Journal: Nature_\|\|_Year: 2020_\|\|_DOI: 10.1038/s41586-020-2286-9_\|\|_Data Source: SARS-CoV-2 Screening Data 2020-21	43	ChEMBL	CHEMBL4303091	20200619	20210802	2536\|2805\|3121\|3559\|3652\|3715\|3957\|4091\|4413\|4829\|16362\|26987\|30323\|37542\|41684\|44093\|53232\|53389\|446727\|447043\|676352\|5280343\|5284616\|5360696\|5362119\|5478883\|6911989\|6918328\|9817231\|9829523\|10113978\|10474335\|11955716\|16195554\|16726095\|24748573\|25126798\|44247568\|45375953\|46907787\|49830258\|57389999\|71549093\|73051434\|86271238\|118598754\|121427831\|122201421\|126961335\|129138801\|132010322\|135398745\|135539077\|135564749\|146047983\|146047984\|146047985	103163840\|103164548\|103167027\|103167216\|103170416\|103172458\|103173857\|103175236\|103177883\|103181943\|103195217\|103202903\|103234890\|103237360\|103266319\|103378026\|103477782\|103479736\|103503415\|103508547\|103511073\|103555944\|103556527\|103562286\|103566848\|103581295\|103605085\|103619997\|103623548\|103724215\|103734272\|104241012\|104246358\|123097007\|131281803\|134449640\|134461021\|136942413\|163334751\|174496643\|242402456\|312467947\|336874558\|336889861\|336891650\|381851019\|381854209\|381877252\|404668490\|404679228\|404718853\|405270161\|405270162\|405270164\|405270165\|405270170\|405270590	null	Toxicity	null	Curation Efforts\|Research and Development	32353859	null	null	null	null	null	57	null	null	null	COVID-19\|COVID19\|Coronavirus\|Corona-virus\|SARS\|SARS2\|SARS-CoV\|SARS-CoV-2\|COVID info from ChEMBL
1409614	Other	Overall antiviral activity against SARS-CoV-2 (isolate France/IDF0372/2020) in the Vero E6 cell line at 48 h based on three assays 1) detection of viral RNA by qRT-PCR (targeting the N-gene), 2) plaque assay using lysate 3 days after addition of compound	Title: A SARS-CoV-2 protein interaction map reveals targets for drug repurposing_\|\|_Abstract: The novel coronavirus SARS-CoV-2, the causative agent of COVID-19 respiratory disease, has infected over 2.3 million people, killed over 160,000, and caused worldwide social and economic disruption1,2. There are currently no antiviral drugs with proven clinical efficacy, nor are there vaccines for its prevention, and these efforts are hampered by limited knowledge of the molecular details of SARS-CoV-2 infection. To address this, we cloned, tagged and expressed 26 of the 29 SARS-CoV-2 proteins in human cells and identified the human proteins physically associated with each using affinity-purification mass spectrometry (AP-MS), identifying 332 high-confidence SARS-CoV-2-human protein-protein interactions (PPIs). Among these, we identify 66 druggable human proteins or host factors targeted by 69 compounds (29 FDA-approved drugs, 12 drugs in clinical trials, and 28 preclinical compounds). Screening a subset of these in multiple viral assays identified two sets of pharmacological agents that displayed antiviral activity: inhibitors of mRNA translation and predicted regulators of the Sigma1 and Sigma2 receptors. Further studies of these host factor targeting agents, including their combination with drugs that directly target viral enzymes, could lead to a therapeutic regimen to treat COVID-19.	Journal: Nature_\|\|_Year: 2020_\|\|_DOI: 10.1038/s41586-020-2286-9_\|\|_Target ChEMBL ID: CHEMBL4303835_\|\|_ChEMBL Target Name: SARS-CoV-2_\|\|_ChEMBL Target Type: ORGANISM - Target is a complete organism_\|\|_Relationship Type: N - Non-molecular target assigned_\|\|_Confidence: Target assigned is non-molecular_\|\|_Data Source: SARS-CoV-2 Screening Data 2020-21	43	ChEMBL	CHEMBL4303092	20200619	20210802	2536\|2562\|2805\|3121\|3559\|3689\|3715\|3957\|4091\|4201\|4413\|5959\|5994\|26987\|29435\|30323\|37542\|44093\|92305\|126388\|153241\|446541\|446727\|449241\|2287238\|5284616\|5360696\|5362119\|6436223\|6911989\|6918328\|9589606\|9817231\|9829523\|9829526\|10113978\|10474335\|16726095\|24826799\|25126798\|44247568\|45375953\|46907787\|49830258\|57389999\|71549093\|86271238\|118598754\|121427831\|122201421\|126961335\|129138801\|132010322\|135564749\|136662663\|145944879\|146047983\|146047984\|146047985	103163840\|103164548\|103167216\|103170416\|103175608\|103177883\|103186198\|103189004\|103202903\|103210632\|103212386\|103216741\|103226686\|103234890\|103237360\|103252427\|103261008\|103266319\|103272786\|103278185\|103321316\|103378026\|103477782\|103508547\|103511073\|103555944\|103562286\|103581295\|103605085\|103605727\|103619997\|103623548\|103724215\|103734272\|103768137\|124960908\|131281803\|134449640\|136942413\|163334751\|174496643\|242343441\|312467794\|312467947\|336874558\|336889861\|381851019\|381854209\|381877252\|404668490\|404679228\|404718853\|405270161\|405270162\|405270163\|405270164\|405270165\|405270170\|405270590	null	Toxicity	null	Curation Efforts\|Research and Development	32353859	null	null	60711\|2697049	546	2697049	59	null	null	null	COVID-19\|COVID19\|Coronavirus\|Corona-virus\|SARS\|SARS2\|SARS-CoV\|SARS-CoV-2\|COVID info from ChEMBL
1409623	Confirmatory	IC90 for antiviral activity against SARS-CoV-2 in the Vero E6 cell line by measuring infectious viral titer of supernatent from compound-treated Vero E6 cells by Median Tissue Culture Infectious Dose (TCID)50 by the method of Reed and Muench	Title: A SARS-CoV-2 protein interaction map reveals targets for drug repurposing_\|\|_Abstract: The novel coronavirus SARS-CoV-2, the causative agent of COVID-19 respiratory disease, has infected over 2.3 million people, killed over 160,000, and caused worldwide social and economic disruption1,2. There are currently no antiviral drugs with proven clinical efficacy, nor are there vaccines for its prevention, and these efforts are hampered by limited knowledge of the molecular details of SARS-CoV-2 infection. To address this, we cloned, tagged and expressed 26 of the 29 SARS-CoV-2 proteins in human cells and identified the human proteins physically associated with each using affinity-purification mass spectrometry (AP-MS), identifying 332 high-confidence SARS-CoV-2-human protein-protein interactions (PPIs). Among these, we identify 66 druggable human proteins or host factors targeted by 69 compounds (29 FDA-approved drugs, 12 drugs in clinical trials, and 28 preclinical compounds). Screening a subset of these in multiple viral assays identified two sets of pharmacological agents that displayed antiviral activity: inhibitors of mRNA translation and predicted regulators of the Sigma1 and Sigma2 receptors. Further studies of these host factor targeting agents, including their combination with drugs that directly target viral enzymes, could lead to a therapeutic regimen to treat COVID-19.	Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation._\|\|_Journal: Nature_\|\|_Year: 2020_\|\|_DOI: 10.1038/s41586-020-2286-9_\|\|_Target ChEMBL ID: CHEMBL4303835_\|\|_ChEMBL Target Name: SARS-CoV-2_\|\|_ChEMBL Target Type: ORGANISM - Target is a complete organism_\|\|_Relationship Type: N - Non-molecular target assigned_\|\|_Confidence: Target assigned is non-molecular_\|\|_Data Source: SARS-CoV-2 Screening Data 2020-21	43	ChEMBL	CHEMBL4303778	20200619	20220830	null	null	null	null	null	Curation Efforts\|Research and Development	32353859	null	null	60711\|2697049	546	2697049	3	3	null	null	COVID-19\|COVID19\|Coronavirus\|Corona-virus\|SARS\|SARS2\|SARS-CoV\|SARS-CoV-2\|COVID info from ChEMBL
1409578	Confirmatory	Determination of antiviral efficacy in high-content imaging assay in Vero E6 cells infected with SARS-CoV-2 (USA-WA1/2020 isolate) at MOI 0.75 after 24 hrs	Determination of antiviral efficacy in high-content imaging assay in Vero E6 cells infected with SARS-CoV-2 (USA-WA1/2020 isolate) at MOI 0.75 after 24 hrs	Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation._\|\|_Target ChEMBL ID: CHEMBL4303835_\|\|_ChEMBL Target Name: SARS-CoV-2_\|\|_ChEMBL Target Type: ORGANISM - Target is a complete organism_\|\|_Relationship Type: N - Non-molecular target assigned_\|\|_Confidence: Target assigned is non-molecular_\|\|_Data Source: SARS-CoV-2 Screening Data 2020-21	43	ChEMBL	CHEMBL4303815	20200619	20220830	null	null	null	null	null	Curation Efforts\|Research and Development	null	null	null	60711\|2697049	546	2697049	18	18	null	null	COVID-19\|COVID19\|Coronavirus\|Corona-virus\|SARS\|SARS2\|SARS-CoV\|SARS-CoV-2\|COVID info from ChEMBL
1409579	Confirmatory	Antiviral activity against SARS-CoV-2 (viral titer) measured by plaque assay in Vero cells at MOI 0.0125 after 24 hr	Antiviral activity against SARS-CoV-2 (viral titer) measured by plaque assay in Vero cells at MOI 0.0125 after 24 hr	Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation._\|\|_Target ChEMBL ID: CHEMBL4303835_\|\|_ChEMBL Target Name: SARS-CoV-2_\|\|_ChEMBL Target Type: ORGANISM - Target is a complete organism_\|\|_Relationship Type: N - Non-molecular target assigned_\|\|_Confidence: Target assigned is non-molecular_\|\|_Data Source: SARS-CoV-2 Screening Data 2020-21	43	ChEMBL	CHEMBL4303812	20200619	20220830	237\|2165\|2536\|2719\|2800\|3191\|3598\|3955\|4046\|4066\|4477\|4746\|4756\|5452\|5475\|6536\|10206\|16779\|33630\|73078\|92727\|95168\|154257\|166548\|169870\|208898\|275182\|441207\|656630\|1069873\|2724385\|3005573\|3033767\|3085092\|5284373\|5284613\|6364534\|6857793\|6918155\|16220172\|46220502\|49803313\|49843517\|57379345\|71496458\|121304016\|135449332	103165858\|103169151\|103169457\|103169732\|103171247\|103190631\|103198077\|103210741\|103220983\|103224092\|103225238\|103228169\|103230651\|103266539\|103267575\|103274161\|103378408\|103439840\|103450658\|103458476\|103516894\|103536664\|103556970\|103558584\|103579643\|103593440\|103600902\|103618544\|103628891\|103707689\|103724215\|103770831\|123100235\|136926964\|160668474\|160677304\|160682217\|160687794\|160703482\|174520514\|174522973\|242217462\|242568127\|242651810\|242651822\|312367127\|381838043\|405273715	null	null	null	Curation Efforts\|Research and Development	null	null	null	60711\|2697049	50	2697049	48	42	null	null	COVID-19\|COVID19\|Coronavirus\|Corona-virus\|SARS\|SARS2\|SARS-CoV\|SARS-CoV-2\|COVID info from ChEMBL
1409582	Confirmatory	IC50 determination at MOI 0.004 using CellTiter- Glo (CTG) assay, performed 3 days post-infection in SARS-CoV-2 infected Vero E6 cells	IC50 determination at MOI 0.004 using CellTiter- Glo (CTG) assay, performed 3 days post-infection in SARS-CoV-2 infected Vero E6 cells	Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation._\|\|_Target ChEMBL ID: CHEMBL4303835_\|\|_ChEMBL Target Name: SARS-CoV-2_\|\|_ChEMBL Target Type: ORGANISM - Target is a complete organism_\|\|_Relationship Type: N - Non-molecular target assigned_\|\|_Confidence: Target assigned is non-molecular_\|\|_Data Source: SARS-CoV-2 Screening Data 2020-21	43	ChEMBL	CHEMBL4303823	20200619	20230629	3396\|6014\|6240\|6536\|12947\|60749\|64646\|67356\|68539\|83818\|123596\|253602\|441362\|441383\|2733525\|3005572\|3246155\|5282398\|21127119	103207344\|103224650\|103385271\|103405309\|103415244\|103458476\|103615376\|103619406\|103660112\|103669325\|103676439\|103770366\|103770658\|103770693\|103770733\|123093976\|194161805\|242169005\|374355352	null	null	null	Curation Efforts\|Research and Development	null	null	null	60711\|2697049	546	2697049	19	12	null	null	COVID-19\|COVID19\|Coronavirus\|Corona-virus\|SARS\|SARS2\|SARS-CoV\|SARS-CoV-2\|COVID info from ChEMBL
1409585	Confirmatory	IC50 determination at MOI 0.01 using CellTiter- Glo (CTG) assay, performed 3 days post-infection in SARS-CoV-2 infected Vero E6 cells	IC50 determination at MOI 0.01 using CellTiter- Glo (CTG) assay, performed 3 days post-infection in SARS-CoV-2 infected Vero E6 cells	Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation._\|\|_Target ChEMBL ID: CHEMBL4303835_\|\|_ChEMBL Target Name: SARS-CoV-2_\|\|_ChEMBL Target Type: ORGANISM - Target is a complete organism_\|\|_Relationship Type: N - Non-molecular target assigned_\|\|_Confidence: Target assigned is non-molecular_\|\|_Data Source: SARS-CoV-2 Screening Data 2020-21	43	ChEMBL	CHEMBL4303826	20200619	20230629	3396\|6014\|6240\|6536\|12947\|60749\|64646\|67356\|68539\|83818\|123596\|253602\|441362\|441383\|2733525\|3005572\|3246155\|5282398\|21127119	103207344\|103224650\|103385271\|103405309\|103415244\|103458476\|103615376\|103619406\|103660112\|103669325\|103676439\|103770366\|103770658\|103770693\|103770733\|123093976\|194161805\|242169005\|374355352	null	null	null	Curation Efforts\|Research and Development	null	null	null	60711\|2697049	546	2697049	19	10	null	null	COVID-19\|COVID19\|Coronavirus\|Corona-virus\|SARS\|SARS2\|SARS-CoV\|SARS-CoV-2\|COVID info from ChEMBL
1409588	Other	Reduction of viral mRNA (RdRp and N) in SARS-CoV-2 infected Vero E6 cells (at MOI 0.1) after 24 hrs	Reduction of viral mRNA (RdRp and N) in SARS-CoV-2 infected Vero E6 cells (at MOI 0.1) after 24 hrs	Target ChEMBL ID: CHEMBL4303835_\|\|_ChEMBL Target Name: SARS-CoV-2_\|\|_ChEMBL Target Type: ORGANISM - Target is a complete organism_\|\|_Relationship Type: N - Non-molecular target assigned_\|\|_Confidence: Target assigned is non-molecular_\|\|_Data Source: SARS-CoV-2 Screening Data 2020-21	43	ChEMBL	CHEMBL4303829	20200619	20230629	12947\|83818	103415244\|103660112	null	null	null	Curation Efforts\|Research and Development	null	null	null	60711\|2697049	546	2697049	2	null	null	null	COVID-19\|COVID19\|Coronavirus\|Corona-virus\|SARS\|SARS2\|SARS-CoV\|SARS-CoV-2\|COVID info from ChEMBL
1409589	Other	Reduction of viral replication in SARS-CoV-2 infected Vero E6 cells (at MOI 0.1) after 24 hrs by TCID50 assay	Reduction of viral replication in SARS-CoV-2 infected Vero E6 cells (at MOI 0.1) after 24 hrs by TCID50 assay	Target ChEMBL ID: CHEMBL4303835_\|\|_ChEMBL Target Name: SARS-CoV-2_\|\|_ChEMBL Target Type: ORGANISM - Target is a complete organism_\|\|_Relationship Type: N - Non-molecular target assigned_\|\|_Confidence: Target assigned is non-molecular_\|\|_Data Source: SARS-CoV-2 Screening Data 2020-21	43	ChEMBL	CHEMBL4303830	20200619	20230629	6240\|12947\|64646\|83818\|123596\|441362	103415244\|103619406\|103660112\|103669325\|103676439\|242169005	null	null	null	Curation Efforts\|Research and Development	null	null	null	60711\|2697049	546	2697049	6	null	null	null	COVID-19\|COVID19\|Coronavirus\|Corona-virus\|SARS\|SARS2\|SARS-CoV\|SARS-CoV-2\|COVID info from ChEMBL
1409590	Other	Reduction of SARS-CoV-2 infection by time of addition assay, with 50uM hydroxychloroquine administered at -2hrs, 0 hrs and 2hrs post-infection	Reduction of SARS-CoV-2 infection by time of addition assay, with 50uM hydroxychloroquine administered at -2hrs, 0 hrs and 2hrs post-infection	Target ChEMBL ID: CHEMBL4303835_\|\|_ChEMBL Target Name: SARS-CoV-2_\|\|_ChEMBL Target Type: ORGANISM - Target is a complete organism_\|\|_Relationship Type: N - Non-molecular target assigned_\|\|_Confidence: Target assigned is non-molecular_\|\|_Data Source: SARS-CoV-2 Screening Data 2020-21	43	ChEMBL	CHEMBL4303831	20200619	20230629	12947	103660112	null	null	null	Curation Efforts\|Research and Development	null	null	null	60711\|2697049	546	2697049	1	null	null	null	COVID-19\|COVID19\|Coronavirus\|Corona-virus\|SARS\|SARS2\|SARS-CoV\|SARS-CoV-2\|COVID info from ChEMBL
1409594	Other	Inhibition of cell viability relative to arbidol control (inhibition index > 1 indicates higher activity) measured by fluorescence (OD590nm) in Vero E6 cells infected with SARS-CoV-2 (strain BavPat1) at MOI 0.002 after 72hrs	Inhibition of cell viability relative to arbidol control (inhibition index > 1 indicates higher activity) measured by fluorescence (OD590nm) in Vero E6 cells infected with SARS-CoV-2 (strain BavPat1) at MOI 0.002 after 72hrs	Target ChEMBL ID: CHEMBL4303835_\|\|_ChEMBL Target Name: SARS-CoV-2_\|\|_ChEMBL Target Type: ORGANISM - Target is a complete organism_\|\|_Relationship Type: N - Non-molecular target assigned_\|\|_Confidence: Target assigned is non-molecular_\|\|_Data Source: SARS-CoV-2 Screening Data 2020-21	43	ChEMBL	CHEMBL4303819	20200619	20220830	204\|288\|460\|464\|564\|896\|904\|936\|938\|967\|1046\|1727\|1892\|1981\|1983\|1984\|1986\|1989\|2018\|2082\|2083\|2122\|2123\|2141\|2145\|2148\|2151\|2159\|2161\|2162\|2170\|2176\|2187\|2194\|2196\|2197\|2202\|2206\|2244\|2247\|2265\|2284\|2309\|2310\|2313\|2315\|2318\|2333\|2337\|2343\|2348\|2375\|2378\|2391\|2406\|2446\|2448\|2449\|2453\|2466\|2468\|2471\|2478\|2480\|2481\|2482\|2519\|2541\|2554\|2557\|2576\|2577\|2581\|2585\|2662\|2717\|2720\|2722\|2724\|2727\|2732\|2733\|2741\|2754\|2756\|2762\|2763\|2788\|2794\|2796\|2797\|2799\|2812\|2893\|2898\|2904\|2907\|2912\|2942\|2950\|2955\|2972\|3019\|3025\|3037\|3038\|3053\|3059\|3081\|3090\|3108\|3114\|3117\|3121\|3132\|3151\|3168\|3169\|3182\|3191\|3194\|3229\|3242\|3276\|3278\|3282\|3291\|3292\|3293\|3295\|3308\|3316\|3324\|3326\|3331\|3332\|3333\|3334\|3335\|3338\|3339\|3341\|3352\|3357\|3362\|3365\|3366\|3371\|3374\|3385\|3394\|3395\|3396\|3397\|3406\|3418\|3435\|3440\|3446\|3463\|3475\|3476\|3478\|3488\|3516\|3559\|3561\|3598\|3606\|3607\|3634\|3639\|3647\|3671\|3673\|3686\|3698\|3702\|3715\|3718\|3724\|3730\|3735\|3736\|3739\|3741\|3742\|3747\|3749\|3759\|3760\|3767\|3784\|3792\|3793\|3825\|3828\|3830\|3878\|3883\|3899\|3902\|3926\|3936\|3947\|3957\|3961\|3965\|4006\|4021\|4030\|4044\|4059\|4060\|4075\|4100\|4101\|4107\|4112\|4122\|4165\|4170\|4173\|4174\|4189\|4197\|4201\|4205\|4211\|4235\|4236\|4237\|4409\|4410\|4463\|4472\|4477\|4485\|4486\|4487\|4488\|4493\|4494\|4495\|4497\|4499\|4507\|4539\|4567\|4583\|4594\|4614\|4621\|4622\|4626\|4628\|4632\|4641\|4649\|4677\|4727\|4737\|4740\|4748\|4754\|4760\|4764\|4767\|4770\|4781\|4806\|4810\|4828\|4829\|4831\|4843\|4847\|4849\|4850\|4855\|4883\|4887\|4888\|4891\|4909\|4911\|4912\|4922\|4943\|4990\|4993\|4994\|5042\|5050\|5073\|5090\|5092\|5094\|5152\|5215\|5233\|5265\|5291\|5311\|5315\|5319\|5323\|5324\|5325\|5326\|5328\|5329\|5330\|5332\|5333\|5335\|5336\|5339\|5340\|5342\|5343\|5344\|5353\|5355\|5359\|5362\|5379\|5381\|5386\|5394\|5405\|5426\|5429\|5430\|5468\|5479\|5482\|5497\|5503\|5505\|5510\|5526\|5531\|5546\|5560\|5564\|5573\|5576\|5578\|5585\|5591\|5593\|5597\|5625\|5632\|5656\|5707\|5717\|5719\|5720\|5723\|5734\|5735\|5736\|5741\|5744\|5746\|5753\|5754\|5755\|5756\|5757\|5763\|5770\|5790\|5794\|5795\|5803\|5818\|5819\|5831\|5833\|5849\|5857\|5865\|5870\|5878\|5883\|5887\|5905\|5917\|5920\|5924\|5959\|5965\|5991\|5994\|5995\|6009\|6014\|6019\|6047\|6048\|6081\|6084\|6093\|6099\|6100\|6103\|6114\|6126\|6135\|6166\|6167\|6169\|6172\|6179\|6197\|6202\|6215\|6230\|6231\|6234\|6237\|6240\|6253\|6256\|6271\|6284\|6291\|6300\|6301\|6305\|6307\|6314\|6461\|6634\|6674\|6741\|6839\|6855\|6883\|7010\|7019\|7083\|7108\|7172\|7184\|7638\|8228\|8246\|8307\|8362\|8478\|8480\|8520\|8567\|8569\|8574\|8667\|8691\|8695\|8732\|8813\|8955\|8980\|9051\|9064\|9066\|9270\|9279\|9324\|9363\|9367\|9373\|9399\|9433\|9458\|9568\|9642\|9703\|9782\|9878\|9903\|9904\|9918\|9934\|10133\|10206\|10391\|10607\|10621\|10648\|10649\|10660\|10745\|10766\|10830\|10921\|10969\|11033\|11065\|11078\|11079\|11111\|11224\|11273\|11289\|11368\|11391\|11548\|11683\|11693\|12035\|12124\|12478\|12492\|12560\|12947\|13109\|13221\|13266\|13770\|13789\|13791\|14130\|14219\|14520\|14709\|15004\|15165\|15209\|15250\|15376\|15432\|15443\|15478\|15723\|15789\|16362\|16363\|16490\|16574\|17134\|17275\|17276\|17460\|17506\|17683\|18087\|18283\|18340\|19003\|19004\|19266\|19379\|19518\|19529\|19604\|19675\|19910\|20179\|20279\|20298\|20749\|20933\|21467\|21700\|21704\|21718\|22162\|22529\|22576\|23565\|23659\|23702\|24066\|24360\|24733\|25249\|26098\|26248\|26534\|26596\|26758\|26964\|27200\|27350\|27447\|27503\|27648\|27661\|27812\|27944\|28061\|28417\|28693\|28767\|28858\|28864\|28871\|30668\|30951\|31072\|31100\|31195\|31307\|31315\|31401\|31728\|32169\|32798\|33254\|33478\|33613\|34040\|34312\|34359\|34632\|35370\|35375\|35455\|35802\|35935\|36207\|36294\|36314\|36431\|36462\|36708\|37083\|37175\|37392\|37542\|37907\|38258\|38853\|38911\|39042\|39147\|39764\|39912\|40127\|40399\|40632\|40634\|40854\|41022\|41114\|41684\|41781\|42373\|42574\|43231\|43507\|44093\|44383\|44564\|47320\|47471\|47528\|47812\|47866\|47896\|47965\|50088\|50248\|50294\|50942\|51038\|51039\|51040\|51081\|51082\|53025\|53232\|53276\|54259\|54360\|54384\|54405\|54454\|54687\|54765\|54840\|54891\|54900\|54911\|55182\|55245\|55329\|55891\|56208\|56704\|56959\|56971\|57363\|57469\|58258\|59772\|60063\|60149\|60164\|60198\|60464\|60490\|60606\|60663\|60700\|60726\|60750\|60758\|60795\|60823\|60825\|60837\|60846\|60855\|60857\|60877\|60934\|60953\|60975\|61100\|62115\|62389\|62413\|62770\|62857\|62878\|62881\|62884\|62886\|62920\|62935\|62969\|62978\|62998\|63002\|63013\|64139\|64142\|64646\|64647\|64710\|64713\|64715\|64722\|64736\|64737\|64740\|64747\|64764\|64781\|64927\|65016\|65324\|65327\|65328\|65335\|65340\|65359\|65394\|65464\|65483\|65492\|65495\|65557\|65632\|65659\|65685\|65755\|65869\|65906\|65935\|65944\|65981\|65999\|6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64925\|103764971\|103764972\|103766361\|103770305\|103770306\|103770309\|103770312\|103770315\|103770317\|103770319\|103770321\|103770323\|103770330\|103770331\|103770338\|103770339\|103770342\|103770354\|103770357\|103770366\|103770369\|103770372\|103770375\|103770379\|103770380\|103770381\|103770382\|103770389\|103770391\|103770393\|103770394\|103770396\|103770401\|103770402\|103770408\|103770410\|103770415\|103770419\|103770421\|103770423\|103770429\|103770433\|103770437\|103770438\|103770444\|103770445\|103770447\|103770452\|103770456\|103770457\|103770461\|103770462\|103770475\|103770476\|103770477\|103770483\|103770486\|103770490\|103770496\|103770497\|103770505\|103770506\|103770510\|103770513\|103770528\|103770543\|103770544\|103770553\|103770569\|103770579\|103770583\|103770587\|103770589\|103770597\|103770600\|103770601\|103770604\|103770607\|103770612\|103770619\|103770624\|103770626\|103770637\|103770642\|103770649\|103770650\|103770660\|103770675\|103770684\|103770692\|103770693\|103770697\|103770698\|103770708\|103770715\|103770728\|103770733\|103770739\|103770740\|103770741\|103770743\|103770744\|103770747\|103770748\|103770753\|103770754\|103770756\|103770759\|103770764\|103770770\|103770774\|103770778\|103770781\|103770792\|103770796\|103770802\|103770803\|103770805\|103770816\|103770819\|103770824\|103770826\|103770828\|103770836\|103770839\|103770848\|103770853\|103770854\|103770858\|103770859\|103770860\|103770863\|103770864\|103770868\|103770870\|103770878\|103770884\|103770887\|103770895\|103770897\|103770899\|103770915\|103770918\|103770924\|103770931\|103770933\|103770944\|103770946\|103770947\|103770948\|103770953\|103770957\|103770958\|103770962\|103770963\|103770970\|103770971\|103770976\|103770985\|103770989\|103770991\|103770994\|103770995\|103770999\|103771001\|103771005\|103771006\|103771010\|103771015\|103771022\|103771024\|103771029\|103771032\|103771033\|103771035\|103771042\|103771044\|103771046\|103771065\|103771080\|103771085\|103771086\|103771092\|103771093\|103771094\|103771095\|103771098\|103771100\|103771101\|103771107\|103771114\|103771115\|103771121\|103771122\|103771133\|103771134\|103771135\|103771136\|103771138\|103771139\|103771143\|103771145\|103771151\|103771154\|103771156\|103771160\|103771465\|103771467\|103771472\|103771489\|103771493\|103771501\|104234176\|104234199\|104234207\|104234232\|	null	null	null	Curation Efforts\|Research and Development	null	null	null	60711\|2697049	546	2697049	1518	null	null	null	COVID-19\|COVID19\|Coronavirus\|Corona-virus\|SARS\|SARS2\|SARS-CoV\|SARS-CoV-2\|COVID info from ChEMBL
1409595	Confirmatory	Antiviral efficacy against SARS-CoV-2 (strain BavPat1) in Vero E6 cells assessed by inhibition of viral RNA replication measured by RT-PCR after 2 days	Antiviral efficacy against SARS-CoV-2 (strain BavPat1) in Vero E6 cells assessed by inhibition of viral RNA replication measured by RT-PCR after 2 days	Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation._\|\|_Target ChEMBL ID: CHEMBL4303835_\|\|_ChEMBL Target Name: SARS-CoV-2_\|\|_ChEMBL Target Type: ORGANISM - Target is a complete organism_\|\|_Relationship Type: N - Non-molecular target assigned_\|\|_Confidence: Target assigned is non-molecular_\|\|_Data Source: SARS-CoV-2 Screening Data 2020-21	43	ChEMBL	CHEMBL4303820	20200619	20220830	4594\|12947\|17134\|56959\|71172\|71587\|123601\|130881\|131411\|197712\|213039\|447043\|5280723\|5309446\|16219921\|54726191\|121304016	103171219\|103175236\|103261123\|103482101\|103557049\|103567590\|103660112\|103770675\|103770728\|103771044\|104234207\|104240781\|123093754\|160693271\|242240797\|242323040\|381838043	null	null	null	Curation Efforts\|Research and Development	null	null	null	60711\|2697049	546	2697049	17	6	null	null	COVID-19\|COVID19\|Coronavirus\|Corona-virus\|SARS\|SARS2\|SARS-CoV\|SARS-CoV-2\|COVID info from ChEMBL
1409598	Other	Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging	Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging	Target ChEMBL ID: CHEMBL4303835_\|\|_ChEMBL Target Name: SARS-CoV-2_\|\|_ChEMBL Target Type: ORGANISM - Target is a complete organism_\|\|_Relationship Type: N - Non-molecular target assigned_\|\|_Confidence: Target assigned is non-molecular_\|\|_Data Source: SARS-CoV-2 Screening Data 2020-21	43	ChEMBL	CHEMBL4303805	20200619	20230314	6\|51\|119\|190\|196\|243\|264\|274\|307\|311\|323\|338\|359\|370\|441\|464\|525\|535\|564\|586\|588\|595\|604\|727\|750\|785\|791\|803\|838\|863\|892\|896\|904\|912\|936\|938\|942\|967\|970\|984\|996\|1018\|1046\|1051\|1060\|1066\|1088\|1110\|1123\|1174\|1175\|1176\|1183\|1212\|1218\|1221\|1228\|1233\|1329\|1348\|1359\|1370\|1400\|1401\|1433\|1456\|1493\|1534\|1564\|1574\|1598\|1645\|1646\|1649\|1676\|1683\|1684\|1694\|1697\|1727\|1732\|1779\|1795\|1858\|1884\|1892\|1893\|1973\|1983\|1985\|1986\|1989\|1990\|2005\|2006\|2018\|2019\|2040\|2044\|2049\|2051\|2052\|2068\|2075\|2082\|2083\|2107\|2120\|2123\|2125\|2126\|2141\|2148\|2151\|2153\|2155\|2159\|2161\|2170\|2176\|2179\|2187\|2194\|2196\|2197\|2201\|2202\|2206\|2214\|2239\|2244\|2253\|2264\|2265\|2266\|2273\|2283\|2303\|2310\|2313\|2315\|2319\|2326\|2333\|2337\|2343\|2355\|2374\|2375\|2378\|2391\|2392\|2396\|2406\|2415\|2435\|2438\|2446\|2448\|2450\|2453\|2455\|2466\|2471\|2475\|2478\|2481\|2482\|2515\|2519\|2528\|2540\|2541\|2554\|2576\|2577\|2585\|2662\|2663\|2682\|2687\|2690\|2708\|2720\|2722\|2723\|2724\|2727\|2728\|2730\|2733\|2741\|2746\|2753\|2754\|2755\|2756\|2762\|2763\|2764\|2769\|2782\|2787\|2788\|2790\|2794\|2797\|2799\|2804\|2812\|2817\|2871\|2880\|2893\|2896\|2907\|2910\|2929\|2941\|2950\|2955\|2972\|2998\|3012\|3016\|3017\|3023\|3025\|3036\|3037\|3038\|3045\|3053\|3059\|3071\|3077\|3081\|3090\|3092\|3101\|3105\|3108\|3117\|3151\|3168\|3177\|3191\|3194\|3197\|3218\|3220\|3221\|3226\|3229\|3241\|3242\|3245\|3247\|3275\|3276\|3278\|3282\|3288\|3291\|3292\|3295\|3307\|3316\|3324\|3326\|3331\|3332\|3334\|3335\|3336\|3339\|3342\|3352\|3357\|3360\|3362\|3365\|3366\|3371\|3373\|3374\|3385\|3388\|3396\|3397\|3401\|3423\|3440\|3463\|3474\|3476\|3478\|3488\|3494\|3499\|3503\|3521\|3538\|3545\|3549\|3552\|3559\|3561\|3598\|3600\|3609\|3610\|3627\|3634\|3639\|3647\|3657\|3663\|3671\|3686\|3688\|3690\|3698\|3702\|3704\|3707\|3712\|3715\|3720\|3728\|3735\|3737\|3739\|3742\|3743\|3744\|3747\|3749\|3759\|3760\|3767\|3793\|3795\|3797\|3799\|3803\|3820\|3822\|3823\|3828\|3830\|3845\|3878\|3883\|3885\|3893\|3902\|3923\|3926\|3932\|3936\|3947\|3950\|3957\|3965\|3968\|3969\|3971\|3973\|3994\|3995\|4008\|4020\|4021\|4030\|4033\|4044\|4055\|4059\|4075\|4086\|4099\|4100\|4101\|4107\|4114\|4116\|4121\|4122\|4133\|4165\|4170\|4173\|4174\|4197\|4201\|4217\|4235\|4236\|4237\|4266\|4283\|4375\|4409\|4418\|4421\|4450\|4452\|4463\|4472\|4476\|4477\|4485\|4486\|4487\|4488\|4493\|4494\|4495\|4499\|4511\|4514\|4515\|4534\|4539\|4549\|4564\|4578\|4583\|4592\|4602\|4614\|4615\|4621\|4622\|4628\|4632\|4652\|4670\|4671\|4684\|4687\|4707\|4708\|4713\|4727\|4737\|4740\|4748\|4753\|4754\|4760\|4764\|4766\|4770\|4781\|4784\|4788\|4806\|4814\|4820\|4823\|4831\|4842\|4843\|4846\|4847\|4849\|4855\|4870\|4875\|4877\|4878\|4883\|4887\|4888\|4909\|4911\|4912\|4921\|4938\|4944\|4971\|4993\|4994\|4996\|5034\|5054\|5059\|5063\|5070\|5073\|5081\|5087\|5090\|5094\|5104\|5143\|5146\|5147\|5160\|5161\|5163\|5166\|5169\|5173\|5175\|5186\|5190\|5192\|5198\|5205\|5215\|5231\|5251\|5258\|5270\|5311\|5315\|5319\|5320\|5323\|5324\|5325\|5326\|5327\|5328\|5329\|5330\|5332\|5333\|5334\|5335\|5336\|5339\|5340\|5342\|5344\|5353\|5354\|5358\|5362\|5368\|5379\|5381\|5394\|5395\|5418\|5424\|5429\|5430\|5443\|5453\|5455\|5469\|5475\|5479\|5482\|5503\|5505\|5510\|5522\|5526\|5531\|5534\|5536\|5546\|5560\|5564\|5571\|5574\|5576\|5578\|5585\|5591\|5597\|5614\|5632\|5641\|5648\|5663\|5665\|5694\|5707\|5712\|5717\|5719\|5720\|5723\|5726\|5730\|5732\|5733\|5734\|5736\|5742\|5745\|5746\|5748\|5753\|5754\|5755\|5756\|5757\|5763\|5770\|5780\|5790\|5795\|5808\|5810\|5818\|5819\|5831\|5833\|5834\|5849\|5852\|5857\|5860\|5862\|5865\|5870\|5878\|5879\|5880\|5881\|5883\|5884\|5887\|5893\|5902\|5905\|5917\|5918\|5932\|5938\|5944\|5950\|5952\|5959\|5960\|5961\|5962\|5970\|5974\|5977\|5988\|5991\|5994\|6009\|6010\|6014\|6019\|6024\|6029\|6035\|6047\|6048\|6049\|6057\|6081\|6084\|6093\|6103\|6106\|6126\|6129\|6133\|6135\|6136\|6137\|6166\|6167\|6168\|6169\|6171\|6172\|6194\|6197\|6199\|6202\|6230\|6231\|6234\|6240\|6244\|6246\|6253\|6255\|6256\|6267\|6268\|6269\|6271\|6284\|6288\|6291\|6301\|6303\|6305\|6314\|6317\|6321\|6400\|6438\|6466\|6476\|6477\|6503\|6549\|6597\|6613\|6623\|6634\|6635\|6651\|6662\|6675\|6726\|6729\|6738\|6741\|6780\|6806\|6832\|6842\|6855\|6872\|6880\|6883\|6909\|6912\|6982\|6989\|7019\|7020\|7083\|7108\|7151\|7172\|7175\|7176\|7184\|7187\|7211\|7232\|7314\|7333\|7347\|7389\|7393\|7427\|7436\|7456\|7533\|7534\|7547\|7550\|7558\|7582\|7588\|7594\|7615\|7619\|7638\|7697\|7817\|8042\|8064\|8215\|8221\|8228\|8246\|8288\|8307\|8313\|8361\|8395\|8400\|8421\|8430\|8434\|8456\|8467\|8478\|8514\|8515\|8520\|8522\|8546\|8567\|8569\|8574\|8593\|8606\|8609\|8614\|8617\|8663\|8667\|8691\|8692\|8694\|8695\|8739\|8778\|8798\|8813\|8820\|8907\|8955\|8961\|8974\|8980\|9015\|9046\|9047\|9062\|9064\|9068\|9082\|9083\|9087\|9270\|9279\|9280\|9301\|9351\|9363\|9367\|9373\|93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103241545\|103241564\|103241573\|103241579\|103241607\|103241616\|103241627\|103241637\|103241784\|103242188\|103242251\|103242300\|103242376\|103242469\|103242914\|103243148\|103243188\|103243627\|103244043\|103244184\|103244284\|103244336\|103244842\|103244854\|103244877\|103244983\|103245065\|103245318\|103245465\|103245517\|103245564\|103245600\|103245821\|103246862\|103246894\|103247271\|103247294\|103247439\|103247616\|103247734\|103247988\|103248266\|103248360\|103248957\|103248980\|103249003\|103249115\|103249137\|103249306\|103249990\|103250040\|103250062\|103250068\|103250337\|103250362\|103250582\|103250605\|103250658\|103250803\|103250959\|103251679\|103251799\|103252419\|103252427\|103252508\|103252877\|103252903\|103253096\|103253261\|103253491\|103254191\|103254254\|103254526\|103254833\|103254993\|103255257\|103255258\|103255460\|103255514\|103255588\|103255724\|103255846\|103255895\|103256239\|103256438\|103256510\|103256585\|103257025\|103257414\|103257527\|103257550\|103257884\|103257993\|103258118\|103258138\|103258602\|103258758\|103258901\|103258907\|103259219\|103259280\|103259311\|103259474\|103259583\|103259826\|103259856\|103260070\|103260137\|103260243\|103260440\|103260660\|103260911\|103261008\|103261222\|103261452\|103262048\|103262836\|103263375\|103263607\|103263649\|103263776\|103264488\|103264620\|103264812\|103264927\|103265273\|103265378\|103266027\|103266319\|103266437\|103266539\|103266593\|103266610\|103266653\|103266824\|103266899\|103267082\|103267103\|103267413\|103267450\|103267492\|103267620\|103267714\|103267861\|103268014\|103268021\|103268291\|103268452\|103269499\|103269662\|103269711\|103271212\|103271420\|103271443\|103271571\|103271734\|103271913\|103271997\|103272062\|103272138\|103272369\|103272403\|103272610\|103272717\|103273186\|103273601\|103273650\|103273904\|103274041\|103274172\|103274177\|103274364\|103274495\|103274646\|103275460\|103275479\|103275697\|103275884\|103276037\|103276085\|103276442\|103276514\|103276735\|103276933\|103277238\|103277310\|103277459\|103277467\|103277548\|103277645\|103277751\|103278222\|103278341\|103278806\|103279132\|103279820\|103279849\|103279950\|103280505\|103280620\|103280636\|103280853\|103281882\|103282173\|103282209\|103282386\|103282499\|103282519\|103282650\|103283478\|103283744\|103283975\|103284100\|103284741\|103284927\|103285099\|103285681\|103285932\|103286284\|103288110\|103288111\|103288166\|103288593\|103288835\|103288972\|103289206\|103289240\|103289379\|103289646\|103290029\|103290097\|103290307\|103290984\|103291064\|103291232\|103291361\|103291571\|103291921\|103292036\|103292372\|103292415\|103292518\|103292786\|103292787\|103292815\|103292864\|103292896\|103292969\|103292984\|103292986\|103293005\|103293038\|103293043\|103293068\|103293682\|103293858\|103294369\|103294373\|103294447\|	null	Toxicity	null	Curation Efforts\|Research and Development	null	null	null	9606\|2697049	25	2697049	5616	null	null	null	COVID-19\|COVID19\|Coronavirus\|Corona-virus\|SARS\|SARS2\|SARS-CoV\|SARS-CoV-2\|COVID info from ChEMBL
1409599	Confirmatory	Determination of IC50 values for inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells after 48 hours by high content imaging	Determination of IC50 values for inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells after 48 hours by high content imaging	Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation._\|\|_Target ChEMBL ID: CHEMBL4303835_\|\|_ChEMBL Target Name: SARS-CoV-2_\|\|_ChEMBL Target Type: ORGANISM - Target is a complete organism_\|\|_Relationship Type: N - Non-molecular target assigned_\|\|_Confidence: Target assigned is non-molecular_\|\|_Data Source: SARS-CoV-2 Screening Data 2020-21	43	ChEMBL	CHEMBL4303806	20200619	20220830	2049\|2880\|3823\|3926\|3957\|6084\|11103\|22324\|51166\|71821\|72331\|92727\|104827\|108144\|121926\|148195\|151193\|166558\|214347\|285033\|406563\|441362\|444025\|467825\|468595\|656641\|680502\|1712095\|2723601\|2724387\|3038494\|4239764\|4581100\|5282407\|5284360\|5311180\|5351307\|5702159\|6413301\|6918543\|9556529\|9852519\|9864510\|9887537\|9889366\|9910986\|10047612\|10182969\|10223146\|11167602\|11282283\|11513676\|11570805\|11681588\|11978813\|12761153\|22049997\|24775005\|25151352\|46926973\|49806644\|53469448\|58298316\|66576990\|121304016\|135413553	103197668\|103197669\|103197958\|103198077\|103209066\|103227500\|103241564\|103241637\|103264812\|103266319\|103269662\|103275479\|103289379\|103304009\|103306071\|103307406\|103310486\|103315998\|103401596\|103464558\|103475263\|103506281\|103535612\|103582308\|103669325\|103672873\|103678990\|103683969\|103689473\|103691394\|103744991\|103770468\|103770819\|103770848\|104247904\|123093463\|124956564\|136923685\|136937804\|160681960\|160682508\|160682669\|160687891\|160692274\|160692474\|160703517\|160703568\|160708511\|160708744\|163314148\|163315720\|163333106\|164141656\|164147217\|174505180\|242179345\|242361486\|242584970\|242591399\|312365754\|318375450\|336907714\|374355250\|381838043\|405270178\|405270412\|405270614	null	Toxicity	null	Curation Efforts\|Research and Development	null	null	null	9606\|2697049	25	2697049	67	46	null	null	COVID-19\|COVID19\|Coronavirus\|Corona-virus\|SARS\|SARS2\|SARS-CoV\|SARS-CoV-2\|COVID info from ChEMBL
1409601	Other	Cytotoxicity index (CI): selectivity for inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells versus toxicity against Caco-2 cells (CC50/IC50)	Cytotoxicity index (CI): selectivity for inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells versus toxicity against Caco-2 cells (CC50/IC50)	Data Source: SARS-CoV-2 Screening Data 2020-21	43	ChEMBL	CHEMBL4303808	20200619	20200619	2049\|2880\|3823\|3926\|3957\|6084\|11103\|22324\|51166\|71821\|72331\|92727\|104827\|108144\|121926\|148195\|151193\|166558\|214347\|285033\|406563\|441362\|444025\|467825\|468595\|656641\|680502\|1712095\|2723601\|2724387\|3038494\|4239764\|4581100\|5282407\|5284360\|5311180\|5351307\|5702159\|6413301\|6918543\|9556529\|9852519\|9864510\|9887537\|9889366\|9910986\|10047612\|10182969\|10223146\|11167602\|11282283\|11513676\|11570805\|11681588\|11978813\|12761153\|22049997\|24775005\|25151352\|46926973\|49806644\|53469448\|58298316\|66576990\|121304016\|135413553	103197668\|103197669\|103197958\|103198077\|103209066\|103227500\|103241564\|103241637\|103264812\|103266319\|103269662\|103275479\|103289379\|103304009\|103306071\|103307406\|103310486\|103315998\|103401596\|103464558\|103475263\|103506281\|103535612\|103582308\|103669325\|103672873\|103678990\|103683969\|103689473\|103691394\|103744991\|103770468\|103770819\|103770848\|104247904\|123093463\|124956564\|136923685\|136937804\|160681960\|160682508\|160682669\|160687891\|160692274\|160692474\|160703517\|160703568\|160708511\|160708744\|163314148\|163315720\|163333106\|164141656\|164147217\|174505180\|242179345\|242361486\|242584970\|242591399\|312365754\|318375450\|336907714\|374355250\|381838043\|405270178\|405270412\|405270614	null	Toxicity	null	Curation Efforts\|Research and Development	null	null	null	9606	null	null	67	null	null	null	COVID-19\|COVID19\|Coronavirus\|Corona-virus\|SARS\|SARS2\|SARS-CoV\|SARS-CoV-2\|COVID info from ChEMBL
1409602	Other	Inhibition of SARS-CoV-2 pseudoparticle entry in Huh-7 cells, assessed by luciferase assay after 72 hrs	Inhibition of SARS-CoV-2 pseudoparticle entry in Huh-7 cells, assessed by luciferase assay after 72 hrs	Target ChEMBL ID: CHEMBL4303835_\|\|_ChEMBL Target Name: SARS-CoV-2_\|\|_ChEMBL Target Type: ORGANISM - Target is a complete organism_\|\|_Relationship Type: N - Non-molecular target assigned_\|\|_Confidence: Target assigned is non-molecular_\|\|_Data Source: SARS-CoV-2 Screening Data 2020-21	43	ChEMBL	CHEMBL4303816	20200619	20200619	2157\|2165\|2520\|2719\|2800\|131411\|3005573	103169732\|103188875\|103190631\|103628891\|104234145\|104240781\|242568127	null	null	null	Curation Efforts\|Research and Development	null	null	null	9606\|2697049	314	2697049	7	null	null	null	COVID-19\|COVID19\|Coronavirus\|Corona-virus\|SARS\|SARS2\|SARS-CoV\|SARS-CoV-2\|COVID info from ChEMBL
1409605	Other	Antiviral activity against SARS-CoV-2 (USA-WA1/2020 strain) measured by imaging in HRCE cells at MOI 0.4 after 96 hrs (reported as hit score from 0-1 for on-disease vs off-disease activity: scores >0.6 considered hits)	Antiviral activity against SARS-CoV-2 (USA-WA1/2020 strain) measured by imaging in HRCE cells at MOI 0.4 after 96 hrs (reported as hit score from 0-1 for on-disease vs off-disease activity: scores >0.6 considered hits)	Target ChEMBL ID: CHEMBL4303835_\|\|_ChEMBL Target Name: SARS-CoV-2_\|\|_ChEMBL Target Type: ORGANISM - Target is a complete organism_\|\|_Relationship Type: N - Non-molecular target assigned_\|\|_Confidence: Target assigned is non-molecular_\|\|_Data Source: SARS-CoV-2 Screening Data 2020-21	43	ChEMBL	CHEMBL4303810	20200619	20220318	137\|204\|237\|305\|323\|342\|359\|444\|525\|586\|892\|896\|936\|957\|978\|1046\|1050\|1110\|1123\|1130\|1174\|1176\|1234\|1570\|1727\|1775\|1892\|1923\|1935\|1981\|1983\|1985\|1986\|1989\|1993\|2005\|2018\|2040\|2075\|2082\|2083\|2092\|2119\|2122\|2123\|2130\|2131\|2136\|2140\|2148\|2153\|2157\|2159\|2161\|2165\|2170\|2178\|2179\|2187\|2194\|2196\|2200\|2216\|2239\|2244\|2249\|2264\|2265\|2266\|2267\|2273\|2284\|2313\|2315\|2320\|2324\|2326\|2327\|2335\|2343\|2366\|2369\|2370\|2372\|2375\|2381\|2405\|2435\|2446\|2448\|2467\|2472\|2474\|2475\|2477\|2478\|2480\|2482\|2484\|2520\|2528\|2536\|2540\|2541\|2551\|2554\|2557\|2562\|2564\|2581\|2583\|2585\|2662\|2663\|2681\|2683\|2710\|2719\|2723\|2727\|2732\|2733\|2749\|2754\|2756\|2762\|2763\|2764\|2780\|2783\|2784\|2787\|2794\|2796\|2797\|2799\|2801\|2803\|2804\|2805\|2882\|2893\|2895\|2907\|2955\|2966\|2972\|2973\|2993\|2995\|2998\|3009\|3019\|3025\|3033\|3037\|3038\|3042\|3045\|3052\|3059\|3074\|3090\|3092\|3103\|3105\|3108\|3111\|3114\|3117\|3151\|3152\|3157\|3158\|3166\|3168\|3169\|3182\|3191\|3194\|3198\|3202\|3218\|3219\|3236\|3241\|3242\|3245\|3275\|3277\|3278\|3280\|3282\|3291\|3292\|3295\|3306\|3307\|3308\|3314\|3316\|3324\|3331\|3332\|3333\|3334\|3335\|3339\|3341\|3342\|3343\|3348\|3352\|3354\|3357\|3360\|3365\|3372\|3373\|3374\|3385\|3386\|3396\|3397\|3406\|3410\|3418\|3440\|3446\|3447\|3450\|3463\|3475\|3476\|3478\|3516\|3518\|3519\|3520\|3547\|3559\|3590\|3598\|3599\|3610\|3634\|3637\|3639\|3647\|3651\|3657\|3658\|3671\|3672\|3673\|3675\|3676\|3678\|3686\|3690\|3696\|3698\|3715\|3718\|3728\|3730\|3741\|3747\|3749\|3752\|3762\|3775\|3779\|3783\|3784\|3792\|3793\|3822\|3825\|3826\|3830\|3878\|3899\|3902\|3913\|3926\|3946\|3948\|3949\|3955\|3957\|3961\|3964\|3965\|3995\|3998\|4008\|4021\|4030\|4031\|4032\|4037\|4046\|4054\|4057\|4059\|4062\|4075\|4078\|4086\|4091\|4100\|4101\|4114\|4117\|4165\|4167\|4168\|4173\|4174\|4184\|4189\|4195\|4197\|4199\|4205\|4212\|4217\|4235\|4237\|4284\|4409\|4410\|4417\|4418\|4421\|4436\|4440\|4456\|4463\|4474\|4477\|4486\|4487\|4493\|4494\|4495\|4497\|4499\|4507\|4511\|4514\|4534\|4539\|4543\|4567\|4583\|4593\|4594\|4595\|4601\|4615\|4619\|4621\|4622\|4626\|4631\|4632\|4633\|4634\|4636\|4649\|4679\|4680\|4684\|4688\|4740\|4746\|4748\|4753\|4756\|4766\|4770\|4775\|4788\|4806\|4810\|4814\|4820\|4822\|4823\|4826\|4828\|4829\|4830\|4831\|4832\|4837\|4839\|4843\|4846\|4848\|4849\|4850\|4884\|4886\|4887\|4888\|4893\|4904\|4908\|4909\|4917\|4919\|4926\|4927\|4932\|4934\|4944\|4946\|4976\|4977\|4991\|4992\|4993\|5029\|5035\|5037\|5039\|5042\|5054\|5070\|5071\|5073\|5078\|5087\|5094\|5095\|5104\|5143\|5147\|5152\|5161\|5205\|5210\|5241\|5243\|5253\|5265\|5291\|5311\|5319\|5320\|5328\|5332\|5335\|5336\|5339\|5342\|5358\|5362\|5374\|5379\|5381\|5386\|5394\|5401\|5419\|5426\|5429\|5430\|5455\|5456\|5457\|5467\|5468\|5472\|5479\|5483\|5487\|5501\|5502\|5503\|5509\|5511\|5517\|5526\|5531\|5533\|5541\|5564\|5565\|5568\|5572\|5574\|5577\|5584\|5585\|5587\|5597\|5603\|5606\|5625\|5632\|5639\|5648\|5656\|5663\|5666\|5717\|5720\|5734\|5736\|5744\|5746\|5749\|5755\|5770\|5775\|5793\|5794\|5819\|5832\|5850\|5865\|5904\|5906\|5910\|5918\|5920\|5960\|5961\|5966\|5978\|5983\|5988\|5991\|6009\|6018\|6024\|6034\|6035\|6041\|6047\|6058\|6077\|6082\|6087\|6098\|6112\|6127\|6137\|6167\|6230\|6231\|6238\|6251\|6253\|6268\|6271\|6279\|6301\|6305\|6306\|6317\|6322\|6436\|6472\|6476\|6613\|6634\|6726\|6729\|6741\|6839\|6843\|6857\|6869\|6880\|6912\|7172\|7405\|7510\|7547\|7697\|7699\|7741\|8197\|8226\|8362\|8364\|8546\|8550\|8567\|8593\|8612\|9046\|9047\|9051\|9270\|9324\|9403\|9409\|9416\|9458\|9642\|9651\|9750\|9782\|9878\|9934\|10114\|10133\|10281\|10391\|10531\|10607\|10621\|10631\|10635\|10770\|10783\|11043\|11289\|11333\|11367\|11693\|12035\|12450\|12478\|12560\|12594\|12947\|13342\|13492\|13791\|14113\|14190\|14652\|14871\|15209\|15443\|15459\|16362\|16363\|16533\|16779\|16961\|17134\|17676\|18087\|18283\|18381\|19675\|19861\|19988\|20058\|20279\|20469\|21138\|21453\|21630\|21704\|22419\|22530\|22571\|23009\|23342\|23497\|24066\|25295\|25429\|25561\|26133\|26248\|26533\|26618\|26757\|26879\|26903\|27661\|27812\|28061\|28417\|28693\|28718\|29112\|30323\|30668\|30751\|30951\|31072\|31401\|31402\|31593\|31635\|31729\|33032\|33624\|33625\|33887\|33919\|33958\|34040\|34312\|34521\|34633\|35375\|35802\|37175\|37369\|37464\|37542\|38072\|38521\|38945\|39042\|39212\|39468\|39562\|39765\|39912\|40632\|40704\|40854\|40973\|41109\|41684\|41781\|41867\|41870\|42574\|43507\|43594\|43672\|43708\|43815\|44112\|44187\|44564\|47517\|47530\|47641\|47811\|47866\|47965\|50192\|50248\|50294\|50942\|51039\|51634\|51712\|53025\|53232\|53708\|54120\|54260\|54385\|54454\|54585\|54687\|54746\|54766\|54841\|54892\|55245\|55645\|56032\|56052\|56206\|56208\|56330\|56339\|56959\|57469\|57697\|58258\|59227\|59693\|59757\|59868\|60149\|60164\|60172\|60198\|60464\|60490\|60606\|60613\|60648\|60651\|60657\|60726\|60749\|60795\|60823\|60835\|60846\|60854\|60855\|60857\|60860\|60871\|60877\|60937\|60946\|61361\|62865\|62894\|62959\|63019\|64139\|64143\|64929\|65015\|65016\|65028\|65264\|65326\|65452\|65492\|65575\|65628\|65659\|65663\|65777\|65781\|65790\|65814\|65859\|65863\|65866\|65894\|65944\|65946\|65948\|65957\|65958\|65981\|65999\|66377\|66593\|66826\|68310\|68591\|68617\|68704\|68707\|68712\|68749\|68770\|68778\|68792\|68801\|68802\|68844\|68861\|68865\|68870\|69550\|70912\|71077\|71141\|71158\|71188\|71203\|71261\|71329\|71334\|71353\|71360\|71384\|71413\|71414\|71616\|71693\|71734\|71739\|71768\|71771\|71777\|71815\|71818\|71821\|71916\|72067\|72093\|72098\|72099\|72106\|72138\|72172\|72281\|72287\|72301\|72325\|73115\|74989\|77991\|77992\|77993\|77999\|82146\|82148\|82153\|84029\|91270\|91668\|92337\|92722\|92727\|92786\|92974\|93055\|100472\|104762\|104842\|104865\|107641\|107706\|107751\|107771\|107841\|107970\|108000\|108052\|108143\|108185\|110635\|114750\|114811\|114905\|115163\|115237\|115355\|115368\|119171\|119182\|119369\|119570\|119584\|119607\|119828\|121396\|121891\|121892\|121919\|122282\|123600\|123606\|123619\|123630\|123631\|123879\|124087\|124093\|124246\|125017\|125564\|126941\|127861\|128019\|128618\|129211\|129228\|130881\|131411\|131536\|131682\|132441\|132971\|132999\|133017\|134018\|134669\|134780\|135191\|145742\|145949\|146570\|148121\|148192\|150311\|151075\|151166\|151171\|152946\|153994\|154059\|154234\|154257\|154417\|156391\|156419\|156709\|157920\|158781\|159269\|163761\|164522\|166548\|167441\|169870\|174174\|174478\|175805\|176077\|176870\|179344\|185460\|189821\|193962\|204108\|208898\|208902\|208908\|208910\|210320\|213039\|213046\|214348\|216237\|216239\|216326\|219024\|219105\|221493\|222154\|222285\|222786\|229295\|247704\|259331\|276389\|285033\|287180\|387447\|392622\|439213\|439280\|439378\|439693\|441074\|441140\|441207\|441243\|441244\|441289\|441290\|441306\|441314\|441350\|441383\|441397\|441401\|441409\|441412\|442912\|443382\|443385\|443869\|443872\|443874\|443879\|443884\|443936\|443944\|443951\|443953\|443958\|443967\|443980\|444008\|444020\|444029\|444031\|444034\|444254\|445643\|446157\|446284\|446541\|446596\|446727\|446987\|447043\|447715\|448812\|449193\|449381\|451668\|452306\|454216\|455041\|460612\|461399\|464205\|468595\|492405\|493570\|636374\|636405\|637568\|638015\|638678\|644241\|656511\|656583\|656604\|656641\|656665\|657201\|657309\|666418\|667467\|667476\|667490\|688020\|688272\|941651\|969472\|1201549\|1274465\|1349907\|1547484\|1548887\|1548943\|1549000\|1549008\|1549120\|1550234\|1794427\|2723601\|2724385\|2733335\|2733526\|2761171\|2836187\|3000226\|3002119\|3002190\|3002820\|3003141\|3005573\|3010818\|3011155\|3033226\|3033538\|3033690\|3033769\|3033825\|3033968\|3034010\|3034034\|3034287\|3036505\|3037918\|3052762\|3052776\|3058754\|3062316\|3081361\|3085092\|3086637\|4369359\|4633677\|4659569\|4660557\|4668801\|5273755\|5277135\|5280343\|5280360\|5280363\|5280644\|5280795\|5281037\|5281071\|5281078\|5281081\|5281104\|5281107\|5281612\|5281613\|5281718\|5281767\|5281792\|5281881\|5282136\|5282138\|5282165\|5282219\|5282226\|5282230\|5282242\|5282381\|5282411\|5282437\|5282440\|5282443\|5282452\|5282459\|5282493\|5282521\|5282593\|5283731\|5283734\|5283748\|5284373\|5284513\|5284514\|5284538\|5284549\|5284550\|5284555\|5284571\|5284583\|5284616\|5284627\|5284632\|5288320\|5288783\|5289394\|5310993\|5311027\|5311037\|5311067\|5311217\|5311221\|5311424\|5311507\|5312125\|5323714\|5324346\|5328940\|5329102\|5330286\|5351362\|5352062\|5353378\|5353536\|5353788\|5353853\|5359371\|5360696\|5360807\|5361918\|5362065\|5362116\|5362119\|5362124\|5362440\|5373773\|5388962\|5447130\|5464343\|5472495\|5479529\|5479530\|5479537\|5479539\|5484727\|5486182\|5487427\|5488548\|5489013\|5493444\|5574924\|5702063\|5702160\|5742832\|6178111\|6323266\|6324616\|6398761\|6398764\|6433083\|6433090\|6433427\|6434217\|6436173\|6436223\|6438378\|6438504\|6442177\|6445230\|6445540\|6450551\|6451149\|6451164\|6456014\|6473883\|6479523\|6480466\|6509979\|6604200\|6610273\|6710661\|6842999\|6914273\|6915744\|6915944\|6917715\|6917864\|6918092\|6918119\|6918155\|6918178\|6918218\|6918248\|6918289\|6918296\|6918303\|6918314\|6918406\|6918456\|6918462\|6918485\|6918493\|6918537\|6918554\|6918558\|6918638\|6918670\|6918837\|6957673\|6975516\|7092779\|9552079\|9553856\|9568614\|9568628\|9570327\|9570757\|9571107\|9574768\|9578005\|9578507\|9578572\|9601226\|9794806\|9811834\|9818306\|9822750\|9822821\|9823820\|9827968\|9828310\|9829523\|9832750\|9832912\|9843042\|9852519\|9853654\|9854073\|9859122\|9862937\|9863672\|9865528\|9867642\|9868491\|9869929\|9870652\|9871419\|9875401\|9876378\|9882882\|9883933\|9887712\|9892071\|9903970\|9904502\|9911830\|9913767\|9915743\|9918693\|9926449\|9930049\|9933004\|9966051\|9992825\|9997821\|10034073\|10041070\|10071196\|10077130\|10089466\|10096344\|10113978\|10177784\|10178705\|10182969\|10184653\|10220503\|10275777\|10280735\|10288191\|10324367\|104292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89\|103526952\|103527157\|103527296\|103529091\|103531615\|103532317\|103532358\|103532381\|103533130\|103533730\|103535612\|103535957\|103536526\|103537350\|103537416\|103537922\|103538380\|103540543\|103542516\|103542924\|103543149\|103543150\|103543151\|103543954\|103544258\|103544522\|103545120\|103545241\|103546496\|103548420\|103549060\|103550738\|103554261\|103554312\|103554336\|103554703\|103554720\|103555930\|103555932\|103555938\|103555944\|103555953\|103555966\|103555967\|103555994\|103555996\|103555999\|103556242\|103556348\|103556884\|103556901\|103556931\|103556970\|103556997\|103557047\|103557049\|103557064\|103557069\|103557519\|103558372\|103558380\|103558387\|103558413\|103558416\|103558436\|103558443\|103558466\|103558519\|103558689\|103558698\|103558705\|103558713\|103558877\|103559525\|103559601\|103562109\|103563347\|103563390\|103563888\|103565844\|103565846\|103565890\|103566300\|103566330\|103566599\|103566630\|103567071\|103567316\|103567551\|103567590\|103567639\|103567682\|103568158\|103568173\|103570000\|103570494\|103572083\|103572184\|103573061\|103574063\|103575487\|103578280\|103578601\|103578669\|103579214\|103579460\|103579775\|103579966\|103582154\|103582308\|103582828\|103585166\|103585278\|103587541\|103587862\|103587944\|103588875\|103588959\|103589681\|103589685\|103589705\|103589714\|103589734\|103589735\|103589738\|103589743\|103589818\|103589878\|103589880\|103589983\|103589984\|103589987\|103590063\|103590218\|103590286\|103590387\|103590392\|103590648\|103590705\|103593440\|103594731\|103594774\|103595115\|103595657\|103596069\|103596121\|103598785\|103599700\|103601520\|103602234\|103602769\|103604037\|103604564\|103605014\|103605056\|103605183\|103606785\|103615376\|103615727\|103619997\|103620148\|103620962\|103621127\|103621259\|103622336\|103623548\|103624065\|103624146\|103628891\|103629338\|103630412\|103630414\|103630897\|103631353\|103632654\|103632713\|103632970\|103633149\|103639257\|103645538\|103646320\|103647247\|103647453\|103647626\|103649168\|103650265\|103650787\|103652178\|103652542\|103654502\|103654782\|103660112\|103677620\|103678811\|103679753\|103680984\|103684353\|103684622\|103684640\|103687554\|103687943\|103689592\|103689672\|103690422\|103691002\|103692894\|103693192\|103696081\|103699058\|103699331\|103700141\|103704123\|103707445\|103707689\|103707694\|103707723\|103707732\|103709388\|103709393\|103711694\|103716863\|103717446\|103722863\|103723003\|103724094\|103724173\|103724215\|103728028\|103734272\|103737203\|103737291\|103737294\|103737810\|103737875\|103738069\|103742680\|103743807\|	null	null	null	Curation Efforts\|Research and Development	null	null	null	9606\|2697049	129229	2697049	1629	null	null	null	COVID-19\|COVID19\|Coronavirus\|Corona-virus\|SARS\|SARS2\|SARS-CoV\|SARS-CoV-2\|COVID info from ChEMBL
1409606	Other	Antiviral activity against SARS-CoV-2 (USA-WA1/2020 strain) measured by imaging in Vero cells at MOI 0.08 after 48 hrs (reported as hit score from 0-1 for on-disease vs off-disease activity: scores >0.6 considered hits)	Antiviral activity against SARS-CoV-2 (USA-WA1/2020 strain) measured by imaging in Vero cells at MOI 0.08 after 48 hrs (reported as hit score from 0-1 for on-disease vs off-disease activity: scores >0.6 considered hits)	Target ChEMBL ID: CHEMBL4303835_\|\|_ChEMBL Target Name: SARS-CoV-2_\|\|_ChEMBL Target Type: ORGANISM - Target is a complete organism_\|\|_Relationship Type: N - Non-molecular target assigned_\|\|_Confidence: Target assigned is non-molecular_\|\|_Data Source: SARS-CoV-2 Screening Data 2020-21	43	ChEMBL	CHEMBL4303811	20200619	20210302	2536\|2719\|3559\|3715\|4217\|10281\|12947\|37542\|57469\|65663\|92727\|131411\|176077\|213039\|392622\|449381\|492405\|637568\|3034034\|5281718\|5362440\|6398764\|6975516\|9882882\|11625818\|23680530\|25151504\|25242512\|44468216\|46216796\|121304016\|135398748	103163840\|103167216\|103169732\|103179607\|103198077\|103244854\|103255258\|103329495\|103383455\|103396795\|103401549\|103512718\|103550738\|103554703\|103567639\|103619997\|103660112\|103724215\|103771064\|104234161\|104234207\|104240781\|104248688\|124966023\|160667005\|160678787\|160692925\|160697744\|163315619\|194161762\|318373795\|381838043	null	null	null	Curation Efforts\|Research and Development	null	null	null	60711\|2697049	50	2697049	32	null	null	null	COVID-19\|COVID19\|Coronavirus\|Corona-virus\|SARS\|SARS2\|SARS-CoV\|SARS-CoV-2\|COVID info from ChEMBL
1409593	Other	Reduction of viral titer in SARS-CoV (MA15) infected mouse lung, assessed by plaque assay after 4 days	Reduction of viral titer in SARS-CoV (MA15) infected mouse lung, assessed by plaque assay after 4 days	Target ChEMBL ID: CHEMBL4303836_\|\|_ChEMBL Target Name: SARS-CoV_\|\|_ChEMBL Target Type: ORGANISM - Target is a complete organism_\|\|_Relationship Type: N - Non-molecular target assigned_\|\|_Confidence: Target assigned is non-molecular_\|\|_Data Source: SARS-CoV-2 Screening Data 2020-21	43	ChEMBL	CHEMBL4303834	20200619	20200619	6240\|83818	103415244\|103676439	null	null	null	Curation Efforts\|Research and Development	null	null	null	10090\|694009	null	694009	2	null	null	null	COVID-19\|COVID19\|Coronavirus\|Corona-virus\|SARS\|SARS2\|SARS-CoV\|SARS-CoV-2\|COVID info from ChEMBL
1409609	Other	Cytotoxicity of compound against Vero E6 cells by MTT assay.	Title: A SARS-CoV-2 protein interaction map reveals targets for drug repurposing_\|\|_Abstract: The novel coronavirus SARS-CoV-2, the causative agent of COVID-19 respiratory disease, has infected over 2.3 million people, killed over 160,000, and caused worldwide social and economic disruption1,2. There are currently no antiviral drugs with proven clinical efficacy, nor are there vaccines for its prevention, and these efforts are hampered by limited knowledge of the molecular details of SARS-CoV-2 infection. To address this, we cloned, tagged and expressed 26 of the 29 SARS-CoV-2 proteins in human cells and identified the human proteins physically associated with each using affinity-purification mass spectrometry (AP-MS), identifying 332 high-confidence SARS-CoV-2-human protein-protein interactions (PPIs). Among these, we identify 66 druggable human proteins or host factors targeted by 69 compounds (29 FDA-approved drugs, 12 drugs in clinical trials, and 28 preclinical compounds). Screening a subset of these in multiple viral assays identified two sets of pharmacological agents that displayed antiviral activity: inhibitors of mRNA translation and predicted regulators of the Sigma1 and Sigma2 receptors. Further studies of these host factor targeting agents, including their combination with drugs that directly target viral enzymes, could lead to a therapeutic regimen to treat COVID-19.	Journal: Nature_\|\|_Year: 2020_\|\|_DOI: 10.1038/s41586-020-2286-9_\|\|_Target ChEMBL ID: CHEMBL4303840_\|\|_ChEMBL Target Name: Vero C1008_\|\|_ChEMBL Target Type: CELL-LINE - Target is a specific cell-line_\|\|_Relationship Type: N - Non-molecular target assigned_\|\|_Confidence: Target assigned is non-molecular_\|\|_Data Source: SARS-CoV-2 Screening Data 2020-21	43	ChEMBL	CHEMBL4303086	20200619	20210802	2536\|2805\|3121\|3559\|3652\|3715\|3957\|4091\|4413\|4829\|16362\|26987\|30323\|37542\|41684\|44093\|53232\|53389\|446727\|447043\|676352\|5280343\|5284616\|5360696\|5362119\|5478883\|6911989\|6918328\|9817231\|9829523\|10113978\|10474335\|11955716\|16195554\|16726095\|24748573\|25126798\|44247568\|45375953\|46907787\|49830258\|57389999\|71549093\|73051434\|86271238\|118598754\|121427831\|122201421\|126961335\|129138801\|132010322\|135398745\|135539077\|135564749\|146047983\|146047984\|146047985	103163840\|103164548\|103167027\|103167216\|103170416\|103172458\|103173857\|103175236\|103177883\|103181943\|103195217\|103202903\|103234890\|103237360\|103266319\|103378026\|103477782\|103479736\|103503415\|103508547\|103511073\|103555944\|103556527\|103562286\|103566848\|103581295\|103605085\|103619997\|103623548\|103724215\|103734272\|104241012\|104246358\|123097007\|131281803\|134449640\|134461021\|136942413\|163334751\|174496643\|242402456\|312467947\|336874558\|336889861\|336891650\|381851019\|381854209\|381877252\|404668490\|404679228\|404718853\|405270161\|405270162\|405270164\|405270165\|405270170\|405270590	null	Toxicity	null	Curation Efforts\|Research and Development	32353859	null	null	60711	546	null	57	null	null	null	COVID-19\|COVID19\|Coronavirus\|Corona-virus\|SARS\|SARS2\|SARS-CoV\|SARS-CoV-2\|COVID info from ChEMBL
1409610	Confirmatory	Activity of compound against Alpha 2C (ADRA2C) adrenergic receptor by displacement of [3H]-rauwolscine	Title: A SARS-CoV-2 protein interaction map reveals targets for drug repurposing_\|\|_Abstract: The novel coronavirus SARS-CoV-2, the causative agent of COVID-19 respiratory disease, has infected over 2.3 million people, killed over 160,000, and caused worldwide social and economic disruption1,2. There are currently no antiviral drugs with proven clinical efficacy, nor are there vaccines for its prevention, and these efforts are hampered by limited knowledge of the molecular details of SARS-CoV-2 infection. To address this, we cloned, tagged and expressed 26 of the 29 SARS-CoV-2 proteins in human cells and identified the human proteins physically associated with each using affinity-purification mass spectrometry (AP-MS), identifying 332 high-confidence SARS-CoV-2-human protein-protein interactions (PPIs). Among these, we identify 66 druggable human proteins or host factors targeted by 69 compounds (29 FDA-approved drugs, 12 drugs in clinical trials, and 28 preclinical compounds). Screening a subset of these in multiple viral assays identified two sets of pharmacological agents that displayed antiviral activity: inhibitors of mRNA translation and predicted regulators of the Sigma1 and Sigma2 receptors. Further studies of these host factor targeting agents, including their combination with drugs that directly target viral enzymes, could lead to a therapeutic regimen to treat COVID-19.	Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation._\|\|_Journal: Nature_\|\|_Year: 2020_\|\|_DOI: 10.1038/s41586-020-2286-9_\|\|_Target ChEMBL ID: CHEMBL1916_\|\|_ChEMBL Target Name: Alpha-2c adrenergic receptor_\|\|_ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain_\|\|_Relationship Type: D - Direct protein target assigned_\|\|_Confidence: Direct single protein target assigned_\|\|_Data Source: SARS-CoV-2 Screening Data 2020-21	43	ChEMBL	CHEMBL4303088	20200619	20220830	2719\|3652\|26987\|9817231\|10474335	103169732\|103237360\|103566848\|103605085\|381854209	152	null	P18825	Curation Efforts\|Research and Development	32353859	null	P18825	9606	null	null	5	4	null	null	COVID-19\|COVID19\|Coronavirus\|Corona-virus\|SARS\|SARS2\|SARS-CoV\|SARS-CoV-2\|COVID info from ChEMBL
1409611	Other	AUC (cytotoxicity %) of compound against Vero E6 cells by MTT assay.	Title: A SARS-CoV-2 protein interaction map reveals targets for drug repurposing_\|\|_Abstract: The novel coronavirus SARS-CoV-2, the causative agent of COVID-19 respiratory disease, has infected over 2.3 million people, killed over 160,000, and caused worldwide social and economic disruption1,2. There are currently no antiviral drugs with proven clinical efficacy, nor are there vaccines for its prevention, and these efforts are hampered by limited knowledge of the molecular details of SARS-CoV-2 infection. To address this, we cloned, tagged and expressed 26 of the 29 SARS-CoV-2 proteins in human cells and identified the human proteins physically associated with each using affinity-purification mass spectrometry (AP-MS), identifying 332 high-confidence SARS-CoV-2-human protein-protein interactions (PPIs). Among these, we identify 66 druggable human proteins or host factors targeted by 69 compounds (29 FDA-approved drugs, 12 drugs in clinical trials, and 28 preclinical compounds). Screening a subset of these in multiple viral assays identified two sets of pharmacological agents that displayed antiviral activity: inhibitors of mRNA translation and predicted regulators of the Sigma1 and Sigma2 receptors. Further studies of these host factor targeting agents, including their combination with drugs that directly target viral enzymes, could lead to a therapeutic regimen to treat COVID-19.	Journal: Nature_\|\|_Year: 2020_\|\|_DOI: 10.1038/s41586-020-2286-9_\|\|_Target ChEMBL ID: CHEMBL4303840_\|\|_ChEMBL Target Name: Vero C1008_\|\|_ChEMBL Target Type: CELL-LINE - Target is a specific cell-line_\|\|_Relationship Type: N - Non-molecular target assigned_\|\|_Confidence: Target assigned is non-molecular_\|\|_Data Source: SARS-CoV-2 Screening Data 2020-21	43	ChEMBL	CHEMBL4303089	20200619	20210802	2536\|2805\|3121\|3559\|3652\|3715\|3957\|4091\|4413\|4829\|16362\|26987\|30323\|37542\|41684\|44093\|53232\|53389\|446727\|447043\|676352\|5280343\|5284616\|5360696\|5362119\|5478883\|6911989\|6918328\|9817231\|9829523\|10113978\|10474335\|11955716\|16195554\|16726095\|24748573\|25126798\|44247568\|45375953\|46907787\|49830258\|57389999\|71549093\|73051434\|86271238\|118598754\|121427831\|122201421\|126961335\|129138801\|132010322\|135398745\|135539077\|135564749\|146047983\|146047984\|146047985	103163840\|103164548\|103167027\|103167216\|103170416\|103172458\|103173857\|103175236\|103177883\|103181943\|103195217\|103202903\|103234890\|103237360\|103266319\|103378026\|103477782\|103479736\|103503415\|103508547\|103511073\|103555944\|103556527\|103562286\|103566848\|103581295\|103605085\|103619997\|103623548\|103724215\|103734272\|104241012\|104246358\|123097007\|131281803\|134449640\|134461021\|136942413\|163334751\|174496643\|242402456\|312467947\|336874558\|336889861\|336891650\|381851019\|381854209\|381877252\|404668490\|404679228\|404718853\|405270161\|405270162\|405270164\|405270165\|405270170\|405270590	null	Toxicity	null	Curation Efforts\|Research and Development	32353859	null	null	60711	546	null	57	null	null	null	COVID-19\|COVID19\|Coronavirus\|Corona-virus\|SARS\|SARS2\|SARS-CoV\|SARS-CoV-2\|COVID info from ChEMBL
1409612	Confirmatory	Activity of compound against Muscarinic acetylcholine receptor M1 (CHRM1) by displacement of 3H-QNB	Title: A SARS-CoV-2 protein interaction map reveals targets for drug repurposing_\|\|_Abstract: The novel coronavirus SARS-CoV-2, the causative agent of COVID-19 respiratory disease, has infected over 2.3 million people, killed over 160,000, and caused worldwide social and economic disruption1,2. There are currently no antiviral drugs with proven clinical efficacy, nor are there vaccines for its prevention, and these efforts are hampered by limited knowledge of the molecular details of SARS-CoV-2 infection. To address this, we cloned, tagged and expressed 26 of the 29 SARS-CoV-2 proteins in human cells and identified the human proteins physically associated with each using affinity-purification mass spectrometry (AP-MS), identifying 332 high-confidence SARS-CoV-2-human protein-protein interactions (PPIs). Among these, we identify 66 druggable human proteins or host factors targeted by 69 compounds (29 FDA-approved drugs, 12 drugs in clinical trials, and 28 preclinical compounds). Screening a subset of these in multiple viral assays identified two sets of pharmacological agents that displayed antiviral activity: inhibitors of mRNA translation and predicted regulators of the Sigma1 and Sigma2 receptors. Further studies of these host factor targeting agents, including their combination with drugs that directly target viral enzymes, could lead to a therapeutic regimen to treat COVID-19.	Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation._\|\|_Journal: Nature_\|\|_Year: 2020_\|\|_DOI: 10.1038/s41586-020-2286-9_\|\|_Target ChEMBL ID: CHEMBL216_\|\|_ChEMBL Target Name: Muscarinic acetylcholine receptor M1_\|\|_ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain_\|\|_Relationship Type: D - Direct protein target assigned_\|\|_Confidence: Direct single protein target assigned_\|\|_Data Source: SARS-CoV-2 Screening Data 2020-21	43	ChEMBL	CHEMBL4303090	20200619	20220830	2719\|3652\|26987\|9817231\|10474335	103169732\|103237360\|103566848\|103605085\|381854209	1128	null	P11229	Curation Efforts\|Research and Development	32353859	null	P11229	9606	null	null	5	2	null	null	COVID-19\|COVID19\|Coronavirus\|Corona-virus\|SARS\|SARS2\|SARS-CoV\|SARS-CoV-2\|COVID info from ChEMBL
1409615	Confirmatory	Displacement of [3H]-DTG from the Sigma2 receptor	Title: A SARS-CoV-2 protein interaction map reveals targets for drug repurposing_\|\|_Abstract: The novel coronavirus SARS-CoV-2, the causative agent of COVID-19 respiratory disease, has infected over 2.3 million people, killed over 160,000, and caused worldwide social and economic disruption1,2. There are currently no antiviral drugs with proven clinical efficacy, nor are there vaccines for its prevention, and these efforts are hampered by limited knowledge of the molecular details of SARS-CoV-2 infection. To address this, we cloned, tagged and expressed 26 of the 29 SARS-CoV-2 proteins in human cells and identified the human proteins physically associated with each using affinity-purification mass spectrometry (AP-MS), identifying 332 high-confidence SARS-CoV-2-human protein-protein interactions (PPIs). Among these, we identify 66 druggable human proteins or host factors targeted by 69 compounds (29 FDA-approved drugs, 12 drugs in clinical trials, and 28 preclinical compounds). Screening a subset of these in multiple viral assays identified two sets of pharmacological agents that displayed antiviral activity: inhibitors of mRNA translation and predicted regulators of the Sigma1 and Sigma2 receptors. Further studies of these host factor targeting agents, including their combination with drugs that directly target viral enzymes, could lead to a therapeutic regimen to treat COVID-19.	Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation._\|\|_Journal: Nature_\|\|_Year: 2020_\|\|_DOI: 10.1038/s41586-020-2286-9_\|\|_Target ChEMBL ID: CHEMBL4105907_\|\|_ChEMBL Target Name: Sigma intracellular receptor 2_\|\|_ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain_\|\|_Relationship Type: D - Direct protein target assigned_\|\|_Confidence: Direct single protein target assigned_\|\|_Data Source: SARS-CoV-2 Screening Data 2020-21	43	ChEMBL	CHEMBL4303093	20200619	20220830	null	null	27346	null	Q5BJF2	Curation Efforts\|Research and Development	32353859	null	Q5BJF2	9606	null	null	6	6	null	null	COVID-19\|COVID19\|Coronavirus\|Corona-virus\|SARS\|SARS2\|SARS-CoV\|SARS-CoV-2\|COVID info from ChEMBL
1409616	Confirmatory	Displacement of [3H]-pentazocin from the Sigma1 receptor	Title: A SARS-CoV-2 protein interaction map reveals targets for drug repurposing_\|\|_Abstract: The novel coronavirus SARS-CoV-2, the causative agent of COVID-19 respiratory disease, has infected over 2.3 million people, killed over 160,000, and caused worldwide social and economic disruption1,2. There are currently no antiviral drugs with proven clinical efficacy, nor are there vaccines for its prevention, and these efforts are hampered by limited knowledge of the molecular details of SARS-CoV-2 infection. To address this, we cloned, tagged and expressed 26 of the 29 SARS-CoV-2 proteins in human cells and identified the human proteins physically associated with each using affinity-purification mass spectrometry (AP-MS), identifying 332 high-confidence SARS-CoV-2-human protein-protein interactions (PPIs). Among these, we identify 66 druggable human proteins or host factors targeted by 69 compounds (29 FDA-approved drugs, 12 drugs in clinical trials, and 28 preclinical compounds). Screening a subset of these in multiple viral assays identified two sets of pharmacological agents that displayed antiviral activity: inhibitors of mRNA translation and predicted regulators of the Sigma1 and Sigma2 receptors. Further studies of these host factor targeting agents, including their combination with drugs that directly target viral enzymes, could lead to a therapeutic regimen to treat COVID-19.	Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation._\|\|_Journal: Nature_\|\|_Year: 2020_\|\|_DOI: 10.1038/s41586-020-2286-9_\|\|_Target ChEMBL ID: CHEMBL287_\|\|_ChEMBL Target Name: Sigma opioid receptor_\|\|_ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain_\|\|_Relationship Type: D - Direct protein target assigned_\|\|_Confidence: Direct single protein target assigned_\|\|_Data Source: SARS-CoV-2 Screening Data 2020-21	43	ChEMBL	CHEMBL4303094	20200619	20220830	null	null	10280	null	Q99720	Curation Efforts\|Research and Development	32353859	null	Q99720	9606	null	null	6	6	null	null	COVID-19\|COVID19\|Coronavirus\|Corona-virus\|SARS\|SARS2\|SARS-CoV\|SARS-CoV-2\|COVID info from ChEMBL
1409617	Confirmatory	Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine	Title: A SARS-CoV-2 protein interaction map reveals targets for drug repurposing_\|\|_Abstract: The novel coronavirus SARS-CoV-2, the causative agent of COVID-19 respiratory disease, has infected over 2.3 million people, killed over 160,000, and caused worldwide social and economic disruption1,2. There are currently no antiviral drugs with proven clinical efficacy, nor are there vaccines for its prevention, and these efforts are hampered by limited knowledge of the molecular details of SARS-CoV-2 infection. To address this, we cloned, tagged and expressed 26 of the 29 SARS-CoV-2 proteins in human cells and identified the human proteins physically associated with each using affinity-purification mass spectrometry (AP-MS), identifying 332 high-confidence SARS-CoV-2-human protein-protein interactions (PPIs). Among these, we identify 66 druggable human proteins or host factors targeted by 69 compounds (29 FDA-approved drugs, 12 drugs in clinical trials, and 28 preclinical compounds). Screening a subset of these in multiple viral assays identified two sets of pharmacological agents that displayed antiviral activity: inhibitors of mRNA translation and predicted regulators of the Sigma1 and Sigma2 receptors. Further studies of these host factor targeting agents, including their combination with drugs that directly target viral enzymes, could lead to a therapeutic regimen to treat COVID-19.	Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation._\|\|_Journal: Nature_\|\|_Year: 2020_\|\|_DOI: 10.1038/s41586-020-2286-9_\|\|_Target ChEMBL ID: CHEMBL1867_\|\|_ChEMBL Target Name: Alpha-2a adrenergic receptor_\|\|_ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain_\|\|_Relationship Type: D - Direct protein target assigned_\|\|_Confidence: Direct single protein target assigned_\|\|_Data Source: SARS-CoV-2 Screening Data 2020-21	43	ChEMBL	CHEMBL4303095	20200619	20220830	null	null	150	null	P08913	Curation Efforts\|Research and Development	32353859	null	P08913	9606	null	null	5	5	null	null	COVID-19\|COVID19\|Coronavirus\|Corona-virus\|SARS\|SARS2\|SARS-CoV\|SARS-CoV-2\|COVID info from ChEMBL
1409618	Confirmatory	Activity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscine	Title: A SARS-CoV-2 protein interaction map reveals targets for drug repurposing_\|\|_Abstract: The novel coronavirus SARS-CoV-2, the causative agent of COVID-19 respiratory disease, has infected over 2.3 million people, killed over 160,000, and caused worldwide social and economic disruption1,2. There are currently no antiviral drugs with proven clinical efficacy, nor are there vaccines for its prevention, and these efforts are hampered by limited knowledge of the molecular details of SARS-CoV-2 infection. To address this, we cloned, tagged and expressed 26 of the 29 SARS-CoV-2 proteins in human cells and identified the human proteins physically associated with each using affinity-purification mass spectrometry (AP-MS), identifying 332 high-confidence SARS-CoV-2-human protein-protein interactions (PPIs). Among these, we identify 66 druggable human proteins or host factors targeted by 69 compounds (29 FDA-approved drugs, 12 drugs in clinical trials, and 28 preclinical compounds). Screening a subset of these in multiple viral assays identified two sets of pharmacological agents that displayed antiviral activity: inhibitors of mRNA translation and predicted regulators of the Sigma1 and Sigma2 receptors. Further studies of these host factor targeting agents, including their combination with drugs that directly target viral enzymes, could lead to a therapeutic regimen to treat COVID-19.	Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation._\|\|_Journal: Nature_\|\|_Year: 2020_\|\|_DOI: 10.1038/s41586-020-2286-9_\|\|_Target ChEMBL ID: CHEMBL1942_\|\|_ChEMBL Target Name: Alpha-2b adrenergic receptor_\|\|_ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain_\|\|_Relationship Type: D - Direct protein target assigned_\|\|_Confidence: Direct single protein target assigned_\|\|_Data Source: SARS-CoV-2 Screening Data 2020-21	43	ChEMBL	CHEMBL4303096	20200619	20220830	2719\|3652\|26987\|9817231\|10474335	103169732\|103237360\|103566848\|103605085\|381854209	151	null	P18089	Curation Efforts\|Research and Development	32353859	null	P18089	9606	null	null	5	2	null	null	COVID-19\|COVID19\|Coronavirus\|Corona-virus\|SARS\|SARS2\|SARS-CoV\|SARS-CoV-2\|COVID info from ChEMBL
1409619	Confirmatory	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	Title: A SARS-CoV-2 protein interaction map reveals targets for drug repurposing_\|\|_Abstract: The novel coronavirus SARS-CoV-2, the causative agent of COVID-19 respiratory disease, has infected over 2.3 million people, killed over 160,000, and caused worldwide social and economic disruption1,2. There are currently no antiviral drugs with proven clinical efficacy, nor are there vaccines for its prevention, and these efforts are hampered by limited knowledge of the molecular details of SARS-CoV-2 infection. To address this, we cloned, tagged and expressed 26 of the 29 SARS-CoV-2 proteins in human cells and identified the human proteins physically associated with each using affinity-purification mass spectrometry (AP-MS), identifying 332 high-confidence SARS-CoV-2-human protein-protein interactions (PPIs). Among these, we identify 66 druggable human proteins or host factors targeted by 69 compounds (29 FDA-approved drugs, 12 drugs in clinical trials, and 28 preclinical compounds). Screening a subset of these in multiple viral assays identified two sets of pharmacological agents that displayed antiviral activity: inhibitors of mRNA translation and predicted regulators of the Sigma1 and Sigma2 receptors. Further studies of these host factor targeting agents, including their combination with drugs that directly target viral enzymes, could lead to a therapeutic regimen to treat COVID-19.	Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation._\|\|_Journal: Nature_\|\|_Year: 2020_\|\|_DOI: 10.1038/s41586-020-2286-9_\|\|_Target ChEMBL ID: CHEMBL211_\|\|_ChEMBL Target Name: Muscarinic acetylcholine receptor M2_\|\|_ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain_\|\|_Relationship Type: D - Direct protein target assigned_\|\|_Confidence: Direct single protein target assigned_\|\|_Data Source: SARS-CoV-2 Screening Data 2020-21	43	ChEMBL	CHEMBL4303774	20200619	20220830	2719\|3652\|26987\|9817231\|10474335	103169732\|103237360\|103566848\|103605085\|381854209	1129	null	P08172	Curation Efforts\|Research and Development	32353859	null	P08172	9606	null	null	5	4	null	null	COVID-19\|COVID19\|Coronavirus\|Corona-virus\|SARS\|SARS2\|SARS-CoV\|SARS-CoV-2\|COVID info from ChEMBL
1409620	Confirmatory	Activity of compound against Muscarinic acetylcholine receptor M3 (CHRM3) by displacement of 3H-QNB	Title: A SARS-CoV-2 protein interaction map reveals targets for drug repurposing_\|\|_Abstract: The novel coronavirus SARS-CoV-2, the causative agent of COVID-19 respiratory disease, has infected over 2.3 million people, killed over 160,000, and caused worldwide social and economic disruption1,2. There are currently no antiviral drugs with proven clinical efficacy, nor are there vaccines for its prevention, and these efforts are hampered by limited knowledge of the molecular details of SARS-CoV-2 infection. To address this, we cloned, tagged and expressed 26 of the 29 SARS-CoV-2 proteins in human cells and identified the human proteins physically associated with each using affinity-purification mass spectrometry (AP-MS), identifying 332 high-confidence SARS-CoV-2-human protein-protein interactions (PPIs). Among these, we identify 66 druggable human proteins or host factors targeted by 69 compounds (29 FDA-approved drugs, 12 drugs in clinical trials, and 28 preclinical compounds). Screening a subset of these in multiple viral assays identified two sets of pharmacological agents that displayed antiviral activity: inhibitors of mRNA translation and predicted regulators of the Sigma1 and Sigma2 receptors. Further studies of these host factor targeting agents, including their combination with drugs that directly target viral enzymes, could lead to a therapeutic regimen to treat COVID-19.	Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation._\|\|_Journal: Nature_\|\|_Year: 2020_\|\|_DOI: 10.1038/s41586-020-2286-9_\|\|_Target ChEMBL ID: CHEMBL245_\|\|_ChEMBL Target Name: Muscarinic acetylcholine receptor M3_\|\|_ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain_\|\|_Relationship Type: D - Direct protein target assigned_\|\|_Confidence: Direct single protein target assigned_\|\|_Data Source: SARS-CoV-2 Screening Data 2020-21	43	ChEMBL	CHEMBL4303775	20200619	20220830	2719\|3652\|26987\|9817231\|10474335	103169732\|103237360\|103566848\|103605085\|381854209	1131	null	P20309	Curation Efforts\|Research and Development	32353859	null	P20309	9606	null	null	5	3	null	null	COVID-19\|COVID19\|Coronavirus\|Corona-virus\|SARS\|SARS2\|SARS-CoV\|SARS-CoV-2\|COVID info from ChEMBL
1409621	Confirmatory	Activity of compound against Muscarinic acetylcholine receptor M4 (CHRM4) by displacement of 3H-QNB	Title: A SARS-CoV-2 protein interaction map reveals targets for drug repurposing_\|\|_Abstract: The novel coronavirus SARS-CoV-2, the causative agent of COVID-19 respiratory disease, has infected over 2.3 million people, killed over 160,000, and caused worldwide social and economic disruption1,2. There are currently no antiviral drugs with proven clinical efficacy, nor are there vaccines for its prevention, and these efforts are hampered by limited knowledge of the molecular details of SARS-CoV-2 infection. To address this, we cloned, tagged and expressed 26 of the 29 SARS-CoV-2 proteins in human cells and identified the human proteins physically associated with each using affinity-purification mass spectrometry (AP-MS), identifying 332 high-confidence SARS-CoV-2-human protein-protein interactions (PPIs). Among these, we identify 66 druggable human proteins or host factors targeted by 69 compounds (29 FDA-approved drugs, 12 drugs in clinical trials, and 28 preclinical compounds). Screening a subset of these in multiple viral assays identified two sets of pharmacological agents that displayed antiviral activity: inhibitors of mRNA translation and predicted regulators of the Sigma1 and Sigma2 receptors. Further studies of these host factor targeting agents, including their combination with drugs that directly target viral enzymes, could lead to a therapeutic regimen to treat COVID-19.	Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation._\|\|_Journal: Nature_\|\|_Year: 2020_\|\|_DOI: 10.1038/s41586-020-2286-9_\|\|_Target ChEMBL ID: CHEMBL1821_\|\|_ChEMBL Target Name: Muscarinic acetylcholine receptor M4_\|\|_ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain_\|\|_Relationship Type: D - Direct protein target assigned_\|\|_Confidence: Direct single protein target assigned_\|\|_Data Source: SARS-CoV-2 Screening Data 2020-21	43	ChEMBL	CHEMBL4303776	20200619	20220830	2719\|3652\|26987\|9817231\|10474335	103169732\|103237360\|103566848\|103605085\|381854209	1132	null	P08173	Curation Efforts\|Research and Development	32353859	null	P08173	9606	null	null	5	4	null	null	COVID-19\|COVID19\|Coronavirus\|Corona-virus\|SARS\|SARS2\|SARS-CoV\|SARS-CoV-2\|COVID info from ChEMBL
1409622	Confirmatory	Activity of compound against Muscarinic acetylcholine receptor M5 (CHRM5) by displacement of 3H-QNB	Title: A SARS-CoV-2 protein interaction map reveals targets for drug repurposing_\|\|_Abstract: The novel coronavirus SARS-CoV-2, the causative agent of COVID-19 respiratory disease, has infected over 2.3 million people, killed over 160,000, and caused worldwide social and economic disruption1,2. There are currently no antiviral drugs with proven clinical efficacy, nor are there vaccines for its prevention, and these efforts are hampered by limited knowledge of the molecular details of SARS-CoV-2 infection. To address this, we cloned, tagged and expressed 26 of the 29 SARS-CoV-2 proteins in human cells and identified the human proteins physically associated with each using affinity-purification mass spectrometry (AP-MS), identifying 332 high-confidence SARS-CoV-2-human protein-protein interactions (PPIs). Among these, we identify 66 druggable human proteins or host factors targeted by 69 compounds (29 FDA-approved drugs, 12 drugs in clinical trials, and 28 preclinical compounds). Screening a subset of these in multiple viral assays identified two sets of pharmacological agents that displayed antiviral activity: inhibitors of mRNA translation and predicted regulators of the Sigma1 and Sigma2 receptors. Further studies of these host factor targeting agents, including their combination with drugs that directly target viral enzymes, could lead to a therapeutic regimen to treat COVID-19.	Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation._\|\|_Journal: Nature_\|\|_Year: 2020_\|\|_DOI: 10.1038/s41586-020-2286-9_\|\|_Target ChEMBL ID: CHEMBL2035_\|\|_ChEMBL Target Name: Muscarinic acetylcholine receptor M5_\|\|_ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain_\|\|_Relationship Type: D - Direct protein target assigned_\|\|_Confidence: Direct single protein target assigned_\|\|_Data Source: SARS-CoV-2 Screening Data 2020-21	43	ChEMBL	CHEMBL4303777	20200619	20220830	2719\|3652\|26987\|9817231\|10474335	103169732\|103237360\|103566848\|103605085\|381854209	1133	null	P08912	Curation Efforts\|Research and Development	32353859	null	P08912	9606	null	null	5	2	null	null	COVID-19\|COVID19\|Coronavirus\|Corona-virus\|SARS\|SARS2\|SARS-CoV\|SARS-CoV-2\|COVID info from ChEMBL
1409624	Confirmatory	hERG binding assays: Displacement of [3H]-Dofetilide (5 nM final) from hERG membranes obtained from HEK293 cells	Title: A SARS-CoV-2 protein interaction map reveals targets for drug repurposing_\|\|_Abstract: The novel coronavirus SARS-CoV-2, the causative agent of COVID-19 respiratory disease, has infected over 2.3 million people, killed over 160,000, and caused worldwide social and economic disruption1,2. There are currently no antiviral drugs with proven clinical efficacy, nor are there vaccines for its prevention, and these efforts are hampered by limited knowledge of the molecular details of SARS-CoV-2 infection. To address this, we cloned, tagged and expressed 26 of the 29 SARS-CoV-2 proteins in human cells and identified the human proteins physically associated with each using affinity-purification mass spectrometry (AP-MS), identifying 332 high-confidence SARS-CoV-2-human protein-protein interactions (PPIs). Among these, we identify 66 druggable human proteins or host factors targeted by 69 compounds (29 FDA-approved drugs, 12 drugs in clinical trials, and 28 preclinical compounds). Screening a subset of these in multiple viral assays identified two sets of pharmacological agents that displayed antiviral activity: inhibitors of mRNA translation and predicted regulators of the Sigma1 and Sigma2 receptors. Further studies of these host factor targeting agents, including their combination with drugs that directly target viral enzymes, could lead to a therapeutic regimen to treat COVID-19.	Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation._\|\|_Journal: Nature_\|\|_Year: 2020_\|\|_DOI: 10.1038/s41586-020-2286-9_\|\|_Target ChEMBL ID: CHEMBL240_\|\|_ChEMBL Target Name: HERG_\|\|_ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain_\|\|_Relationship Type: D - Direct protein target assigned_\|\|_Confidence: Direct single protein target assigned_\|\|_Data Source: SARS-CoV-2 Screening Data 2020-21	43	ChEMBL	CHEMBL4303779	20200619	20220830	null	null	3757	null	Q12809	Curation Efforts\|Research and Development	32353859	null	Q12809	9606	45	null	5	5	null	null	COVID-19\|COVID19\|Coronavirus\|Corona-virus\|SARS\|SARS2\|SARS-CoV\|SARS-CoV-2\|COVID info from ChEMBL
1409625	Other	Selectivity index for SigmaR1/R2 on-target Kd values vs. hERG ion channel	Title: A SARS-CoV-2 protein interaction map reveals targets for drug repurposing_\|\|_Abstract: The novel coronavirus SARS-CoV-2, the causative agent of COVID-19 respiratory disease, has infected over 2.3 million people, killed over 160,000, and caused worldwide social and economic disruption1,2. There are currently no antiviral drugs with proven clinical efficacy, nor are there vaccines for its prevention, and these efforts are hampered by limited knowledge of the molecular details of SARS-CoV-2 infection. To address this, we cloned, tagged and expressed 26 of the 29 SARS-CoV-2 proteins in human cells and identified the human proteins physically associated with each using affinity-purification mass spectrometry (AP-MS), identifying 332 high-confidence SARS-CoV-2-human protein-protein interactions (PPIs). Among these, we identify 66 druggable human proteins or host factors targeted by 69 compounds (29 FDA-approved drugs, 12 drugs in clinical trials, and 28 preclinical compounds). Screening a subset of these in multiple viral assays identified two sets of pharmacological agents that displayed antiviral activity: inhibitors of mRNA translation and predicted regulators of the Sigma1 and Sigma2 receptors. Further studies of these host factor targeting agents, including their combination with drugs that directly target viral enzymes, could lead to a therapeutic regimen to treat COVID-19.	Journal: Nature_\|\|_Year: 2020_\|\|_DOI: 10.1038/s41586-020-2286-9_\|\|_Data Source: SARS-CoV-2 Screening Data 2020-21	43	ChEMBL	CHEMBL4303780	20200619	20200619	2719\|3652\|9817231\|10474335	103169732\|103237360\|103566848\|381854209	null	null	null	Curation Efforts\|Research and Development	32353859	null	null	null	null	null	4	null	null	null	COVID-19\|COVID19\|Coronavirus\|Corona-virus\|SARS\|SARS2\|SARS-CoV\|SARS-CoV-2\|COVID info from ChEMBL
1409580	Confirmatory	Cell viability measured by CellTiter-Glo assay in Vero cells at MOI 0.05 after 72hr	Cell viability measured by CellTiter-Glo assay in Vero cells at MOI 0.05 after 72hr	Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation._\|\|_Target ChEMBL ID: CHEMBL391_\|\|_ChEMBL Target Name: Vero_\|\|_ChEMBL Target Type: CELL-LINE - Target is a specific cell-line_\|\|_Relationship Type: N - Non-molecular target assigned_\|\|_Confidence: Target assigned is non-molecular_\|\|_Data Source: SARS-CoV-2 Screening Data 2020-21	43	ChEMBL	CHEMBL4303813	20200619	20220830	237\|2165\|2536\|2719\|2800\|3191\|3598\|3955\|4046\|4066\|4477\|4746\|4756\|5452\|5475\|6536\|10206\|16779\|33630\|73078\|92727\|95168\|154257\|166548\|169870\|208898\|275182\|441207\|656630\|1069873\|2724385\|3005573\|3033767\|3085092\|5284373\|5284613\|6364534\|6857793\|6918155\|16220172\|46220502\|49803313\|49843517\|57379345\|71496458\|121304016\|135449332	103165858\|103169151\|103169457\|103169732\|103171247\|103190631\|103198077\|103210741\|103220983\|103224092\|103225238\|103228169\|103230651\|103266539\|103267575\|103274161\|103378408\|103439840\|103450658\|103458476\|103516894\|103536664\|103556970\|103558584\|103579643\|103593440\|103600902\|103618544\|103628891\|103707689\|103724215\|103770831\|123100235\|136926964\|160668474\|160677304\|160682217\|160687794\|160703482\|174520514\|174522973\|242217462\|242568127\|242651810\|242651822\|312367127\|381838043\|405273715	null	null	null	Curation Efforts\|Research and Development	null	null	null	60711	50	null	48	6	null	null	COVID-19\|COVID19\|Coronavirus\|Corona-virus\|SARS\|SARS2\|SARS-CoV\|SARS-CoV-2\|COVID info from ChEMBL
1409581	Other	Selectivity index for antiviral vs cytotoxic activity in Vero cells (CC50/IC50)	Selectivity index for antiviral vs cytotoxic activity in Vero cells (CC50/IC50)	Data Source: SARS-CoV-2 Screening Data 2020-21	43	ChEMBL	CHEMBL4303814	20200619	20200619	237\|2165\|2536\|2719\|2800\|3191\|3598\|3955\|4046\|4066\|4477\|4746\|4756\|5452\|5475\|6536\|10206\|16779\|33630\|73078\|92727\|95168\|154257\|166548\|169870\|208898\|275182\|441207\|656630\|1069873\|2724385\|3005573\|3033767\|3085092\|5284373\|5284613\|6364534\|6857793\|6918155\|16220172\|46220502\|49803313\|49843517\|57379345\|71496458\|121304016\|135449332	103165858\|103169151\|103169457\|103169732\|103171247\|103190631\|103198077\|103210741\|103220983\|103224092\|103225238\|103228169\|103230651\|103266539\|103267575\|103274161\|103378408\|103439840\|103450658\|103458476\|103516894\|103536664\|103556970\|103558584\|103579643\|103593440\|103600902\|103618544\|103628891\|103707689\|103724215\|103770831\|123100235\|136926964\|160668474\|160677304\|160682217\|160687794\|160703482\|174520514\|174522973\|242217462\|242568127\|242651810\|242651822\|312367127\|381838043\|405273715	null	null	null	Curation Efforts\|Research and Development	null	null	null	null	null	null	48	null	null	null	COVID-19\|COVID19\|Coronavirus\|Corona-virus\|SARS\|SARS2\|SARS-CoV\|SARS-CoV-2\|COVID info from ChEMBL
1409583	Confirmatory	CC50 determination at MOI 0.004 using CellTiter- Glo (CTG) assay, performed 3 days post-infection in Vero E6 cells	CC50 determination at MOI 0.004 using CellTiter- Glo (CTG) assay, performed 3 days post-infection in Vero E6 cells	Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation._\|\|_Target ChEMBL ID: CHEMBL4303840_\|\|_ChEMBL Target Name: Vero C1008_\|\|_ChEMBL Target Type: CELL-LINE - Target is a specific cell-line_\|\|_Relationship Type: N - Non-molecular target assigned_\|\|_Confidence: Target assigned is non-molecular_\|\|_Data Source: SARS-CoV-2 Screening Data 2020-21	43	ChEMBL	CHEMBL4303824	20200619	20220830	3396\|6014\|6240\|6536\|12947\|60749\|64646\|67356\|68539\|83818\|123596\|253602\|441362\|441383\|2733525\|3005572\|3246155\|5282398\|21127119	103207344\|103224650\|103385271\|103405309\|103415244\|103458476\|103615376\|103619406\|103660112\|103669325\|103676439\|103770366\|103770658\|103770693\|103770733\|123093976\|194161805\|242169005\|374355352	null	null	null	Curation Efforts\|Research and Development	null	null	null	60711	546	null	19	2	null	null	COVID-19\|COVID19\|Coronavirus\|Corona-virus\|SARS\|SARS2\|SARS-CoV\|SARS-CoV-2\|COVID info from ChEMBL
1409584	Other	Selectivity index for antiviral activity vs cytotoxicity (CC50/IC50) in Vero E6 cells at MOI 0.004	Selectivity index for antiviral activity vs cytotoxicity (CC50/IC50) in Vero E6 cells at MOI 0.004	Data Source: SARS-CoV-2 Screening Data 2020-21	43	ChEMBL	CHEMBL4303825	20200619	20200619	3396\|6014\|6240\|6536\|12947\|64646\|67356\|68539\|83818\|123596\|441362\|441383\|2733525\|3005572\|3246155\|5282398	103207344\|103224650\|103405309\|103415244\|103458476\|103619406\|103660112\|103669325\|103676439\|103770366\|103770658\|103770693\|103770733\|194161805\|242169005\|374355352	null	Toxicity	null	Curation Efforts\|Research and Development	null	null	null	null	null	null	16	null	null	null	COVID-19\|COVID19\|Coronavirus\|Corona-virus\|SARS\|SARS2\|SARS-CoV\|SARS-CoV-2\|COVID info from ChEMBL
1409586	Confirmatory	CC50 determination at MOI 0.01 using CellTiter- Glo (CTG) assay, performed 3 days post-infection in Vero E6 cells	CC50 determination at MOI 0.01 using CellTiter- Glo (CTG) assay, performed 3 days post-infection in Vero E6 cells	Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation._\|\|_Target ChEMBL ID: CHEMBL4303840_\|\|_ChEMBL Target Name: Vero C1008_\|\|_ChEMBL Target Type: CELL-LINE - Target is a specific cell-line_\|\|_Relationship Type: N - Non-molecular target assigned_\|\|_Confidence: Target assigned is non-molecular_\|\|_Data Source: SARS-CoV-2 Screening Data 2020-21	43	ChEMBL	CHEMBL4303827	20200619	20220830	3396\|6014\|6240\|6536\|12947\|60749\|64646\|67356\|68539\|83818\|123596\|253602\|441362\|441383\|2733525\|3005572\|3246155\|5282398\|21127119	103207344\|103224650\|103385271\|103405309\|103415244\|103458476\|103615376\|103619406\|103660112\|103669325\|103676439\|103770366\|103770658\|103770693\|103770733\|123093976\|194161805\|242169005\|374355352	null	null	null	Curation Efforts\|Research and Development	null	null	null	60711	546	null	19	2	null	null	COVID-19\|COVID19\|Coronavirus\|Corona-virus\|SARS\|SARS2\|SARS-CoV\|SARS-CoV-2\|COVID info from ChEMBL
1409587	Other	Selectivity index for antiviral activity vs cytotoxicity (CC50/IC50) in Vero E6 cells at MOI 0.01	Selectivity index for antiviral activity vs cytotoxicity (CC50/IC50) in Vero E6 cells at MOI 0.01	Data Source: SARS-CoV-2 Screening Data 2020-21	43	ChEMBL	CHEMBL4303828	20200619	20200619	3396\|6014\|6240\|6536\|12947\|64646\|67356\|68539\|83818\|123596\|441362\|441383\|2733525\|3005572\|3246155\|5282398	103207344\|103224650\|103405309\|103415244\|103458476\|103619406\|103660112\|103669325\|103676439\|103770366\|103770658\|103770693\|103770733\|194161805\|242169005\|374355352	null	Toxicity	null	Curation Efforts\|Research and Development	null	null	null	null	null	null	16	null	null	null	COVID-19\|COVID19\|Coronavirus\|Corona-virus\|SARS\|SARS2\|SARS-CoV\|SARS-CoV-2\|COVID info from ChEMBL
1409591	Other	Reduction of SARS spike protein-mediated cell fusion using BlaM pseudovirus assay system in BSC1 cells	Reduction of SARS spike protein-mediated cell fusion using BlaM pseudovirus assay system in BSC1 cells	Target ChEMBL ID: CHEMBL4303836_\|\|_ChEMBL Target Name: SARS-CoV_\|\|_ChEMBL Target Type: ORGANISM - Target is a complete organism_\|\|_Relationship Type: N - Non-molecular target assigned_\|\|_Confidence: Target assigned is non-molecular_\|\|_Data Source: SARS-CoV-2 Screening Data 2020-21	43	ChEMBL	CHEMBL4303832	20200619	20200619	6240\|83818	103415244\|103676439	null	null	null	Curation Efforts\|Research and Development	null	null	null	9534\|694009	579	694009	2	null	null	null	COVID-19\|COVID19\|Coronavirus\|Corona-virus\|SARS\|SARS2\|SARS-CoV\|SARS-CoV-2\|COVID info from ChEMBL
1409592	Other	Reduction of weight loss in SARS-CoV (MA15) infected mice after 4 days	Reduction of weight loss in SARS-CoV (MA15) infected mice after 4 days	Target ChEMBL ID: CHEMBL4303836_\|\|_ChEMBL Target Name: SARS-CoV_\|\|_ChEMBL Target Type: ORGANISM - Target is a complete organism_\|\|_Relationship Type: N - Non-molecular target assigned_\|\|_Confidence: Target assigned is non-molecular_\|\|_Data Source: SARS-CoV-2 Screening Data 2020-21	43	ChEMBL	CHEMBL4303833	20200619	20200619	6240\|83818	103415244\|103676439	null	null	null	Curation Efforts\|Research and Development	null	null	null	10090\|694009	null	694009	2	null	null	null	COVID-19\|COVID19\|Coronavirus\|Corona-virus\|SARS\|SARS2\|SARS-CoV\|SARS-CoV-2\|COVID info from ChEMBL
1409596	Confirmatory	Cytotoxicity (CC50) determination in Vero E6 cells measured by fluorescence (OD590nm)	Cytotoxicity (CC50) determination in Vero E6 cells measured by fluorescence (OD590nm)	Target ChEMBL ID: CHEMBL4303840_\|\|_ChEMBL Target Name: Vero C1008_\|\|_ChEMBL Target Type: CELL-LINE - Target is a specific cell-line_\|\|_Relationship Type: N - Non-molecular target assigned_\|\|_Confidence: Target assigned is non-molecular_\|\|_Data Source: SARS-CoV-2 Screening Data 2020-21	43	ChEMBL	CHEMBL4303821	20200619	20200619	4594\|12947\|17134\|71172\|71587\|131411\|447043\|5280723\|5309446\|16219921\|54726191	103171219\|103175236\|103557049\|103567590\|103660112\|103770728\|104240781\|123093754\|160693271\|242240797\|242323040	null	Toxicity	null	Curation Efforts\|Research and Development	null	null	null	60711	546	null	11	null	null	null	COVID-19\|COVID19\|Coronavirus\|Corona-virus\|SARS\|SARS2\|SARS-CoV\|SARS-CoV-2\|COVID info from ChEMBL
1409597	Other	Selectivity index for antiviral vs cytotoxic effect in Vero E6 cells (CC50/EC50)	Selectivity index for antiviral vs cytotoxic effect in Vero E6 cells (CC50/EC50)	Data Source: SARS-CoV-2 Screening Data 2020-21	43	ChEMBL	CHEMBL4303822	20200619	20200619	4594\|12947\|17134\|71172\|71587\|131411\|447043\|5280723\|5309446\|16219921\|54726191	103171219\|103175236\|103557049\|103567590\|103660112\|103770728\|104240781\|123093754\|160693271\|242240797\|242323040	null	null	null	Curation Efforts\|Research and Development	null	null	null	null	null	null	11	null	null	null	COVID-19\|COVID19\|Coronavirus\|Corona-virus\|SARS\|SARS2\|SARS-CoV\|SARS-CoV-2\|COVID info from ChEMBL
1409600	Confirmatory	Toxicity against Caco-2 cells determined at 48 hours by intracellular ATP concentration using the CellTiter-Glo Luminescent Cell Viability Assay	Toxicity against Caco-2 cells determined at 48 hours by intracellular ATP concentration using the CellTiter-Glo Luminescent Cell Viability Assay	Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation._\|\|_Target ChEMBL ID: CHEMBL614058_\|\|_ChEMBL Target Name: Caco-2_\|\|_ChEMBL Target Type: CELL-LINE - Target is a specific cell-line_\|\|_Relationship Type: N - Non-molecular target assigned_\|\|_Confidence: Target assigned is non-molecular_\|\|_Data Source: SARS-CoV-2 Screening Data 2020-21	43	ChEMBL	CHEMBL4303807	20200619	20220830	2049\|2880\|3823\|3926\|3957\|6084\|11103\|22324\|51166\|71821\|72331\|92727\|104827\|108144\|121926\|148195\|151193\|166558\|214347\|285033\|406563\|441362\|444025\|467825\|468595\|656641\|680502\|1712095\|2723601\|2724387\|3038494\|4239764\|4581100\|5282407\|5284360\|5311180\|5351307\|5702159\|6413301\|6918543\|9556529\|9852519\|9864510\|9887537\|9889366\|9910986\|10047612\|10182969\|10223146\|11167602\|11282283\|11513676\|11570805\|11681588\|11978813\|12761153\|22049997\|24775005\|25151352\|46926973\|49806644\|53469448\|58298316\|66576990\|121304016\|135413553	103197668\|103197669\|103197958\|103198077\|103209066\|103227500\|103241564\|103241637\|103264812\|103266319\|103269662\|103275479\|103289379\|103304009\|103306071\|103307406\|103310486\|103315998\|103401596\|103464558\|103475263\|103506281\|103535612\|103582308\|103669325\|103672873\|103678990\|103683969\|103689473\|103691394\|103744991\|103770468\|103770819\|103770848\|104247904\|123093463\|124956564\|136923685\|136937804\|160681960\|160682508\|160682669\|160687891\|160692274\|160692474\|160703517\|160703568\|160708511\|160708744\|163314148\|163315720\|163333106\|164141656\|164147217\|174505180\|242179345\|242361486\|242584970\|242591399\|312365754\|318375450\|336907714\|374355250\|381838043\|405270178\|405270412\|405270614	null	Toxicity	null	Curation Efforts\|Research and Development	null	null	null	9606	25	null	67	28	null	null	COVID-19\|COVID19\|Coronavirus\|Corona-virus\|SARS\|SARS2\|SARS-CoV\|SARS-CoV-2\|COVID info from ChEMBL
1409604	Other	Assessment of cytotoxicity in Huh-7 cells, assessed as % inhibition of cell viability by Celltiter-Glo assay after 48 hrs	Assessment of cytotoxicity in Huh-7 cells, assessed as % inhibition of cell viability by Celltiter-Glo assay after 48 hrs	Target ChEMBL ID: CHEMBL614039_\|\|_ChEMBL Target Name: Huh-7_\|\|_ChEMBL Target Type: CELL-LINE - Target is a specific cell-line_\|\|_Relationship Type: N - Non-molecular target assigned_\|\|_Confidence: Target assigned is non-molecular_\|\|_Data Source: SARS-CoV-2 Screening Data 2020-21	43	ChEMBL	CHEMBL4303818	20200619	20200619	2157\|2165\|2520\|2719\|2800\|131411\|3005573	103169732\|103188875\|103190631\|103628891\|104234145\|104240781\|242568127	null	Toxicity	null	Curation Efforts\|Research and Development	null	null	null	9606	314	null	7	null	null	null	COVID-19\|COVID19\|Coronavirus\|Corona-virus\|SARS\|SARS2\|SARS-CoV\|SARS-CoV-2\|COVID info from ChEMBL
1706	Screening	QFRET-based primary biochemical high throughput screening assay to identify inhibitors of the SARS coronavirus 3C-like Protease (3CLPro)	Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC)_\|\|_Center Affiliation: The Scripps Research Institute (TSRI)_\|\|_Assay Provider: Valerie Tokars and Andrew Mesecar, University of Illinois at Chicago (UIC)_\|\|_Network: Molecular Libraries Probe Production Centers Network (MLPCN)_\|\|_Grant Proposal Number: 1-R03-MH084162-01A1_\|\|_Grant Proposal PI: Valerie Tokars and Andrew Mesecar, UIC_\|\|_External Assay ID: 3CLPRO_INH_QFRET_1536_%INH_\|\|_Name: QFRET-based primary biochemical high throughput screening assay to identify inhibitors of the SARS coronavirus 3C-like Protease (3CLPro)_\|\|_Description:_\|\|_Coronaviruses are enveloped, large plus-strand RNA viruses that cause the common cold and other disorders such as lower respiratory tract infections and diarrhea (1). In 2003, the novel SARS coronavirus (SARS-CoV) was identified (2, 3) as the etiological agent of the global epidemic of severe acute respiratory syndrome (SARS), an atypical pneumonia that led to progressive respiratory failure in 8000 individuals and 800 deaths by July of that year (4). The SARS-CoV genome encodes a polypeptide that is proteolytically processed by two main proteases, one of which is the 3C-like protease (3CLpro). This chemotrypsin-like cysteine protease is essential for proteolytic processing of the coronavirus polyprotein and thus viral gene expression (5). The protein exists as a dimer/monomer mixture in solution and the dimer was confirmed to be the active species for the enzyme reaction (6). The current absence of a vaccine to prevent SARS infection, the possibility of future SARS epidemics, the recent cloning and expression of recombinant SARS 3CLpro (7), along with studies showing that 3CLpro is essential for viral life cycle, support a role for 3CL-pro as an important pathogenic component of SARS-CoV. The identification of specific inhibitors of 3CLpro will add insights into the biology of SARS-CoV infection of avian and mammalian cells, and serve as valuable tools for inhibiting SARS-CoV replication._\|\|_References:_\|\|_1. Myint, S.H., Human coronavirus infections, in The Coronaviridae, S.G. Siddell, Editor. 1995, Plenum Press. p. 389-401._\|\|_2. Ksiazek, T.G., Erdman, D., Goldsmith, C.S., Zaki, S.R., Peret, T., Emery, S., Tong, S., Urbani, C., Comer, J.A., Lim, W., Rollin, P.E., Dowell, S.F., Ling, A.E., Humphrey, C.D., Shieh, W.J., Guarner, J., Paddock, C.D., Rota, P., Fields, B., DeRisi, J., Yang, J.Y., Cox, N., Hughes, J.M., LeDuc, J.W., Bellini, W.J., and Anderson, L.J., A novel coronavirus associated with severe acute respiratory syndrome. N Engl J Med, 2003. 348(20): p. 1953-66._\|\|_3. Drosten, C., Gunther, S., Preiser, W., van der Werf, S., Brodt, H.R., Becker, S., Rabenau, H., Panning, M., Kolesnikova, L., Fouchier, R.A., Berger, A., Burguiere, A.M., Cinatl, J., Eickmann, M., Escriou, N., Grywna, K., Kramme, S., Manuguerra, J.C., Muller, S., Rickerts, V., Sturmer, M., Vieth, S., Klenk, H.D., Osterhaus, A.D., Schmitz, H., and Doerr, H.W., Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N Engl J Med, 2003. 348(20): p. 1967-76._\|\|_4. Ziebuhr, J., Molecular biology of severe acute respiratory syndrome coronavirus. Curr Opin Microbiol, 2004. 7(4): p. 412-9._\|\|_5. Yang, H., Bartlam, M., and Rao, Z., Drug design targeting the main protease, the Achilles' heel of coronaviruses. Curr Pharm Des, 2006. 12(35): p. 4573-90._\|\|_6. Lai, L., Han, X., Chen, H., Wei, P., Huang, C., Liu, S., Fan, K., Zhou, L., Liu, Z., Pei, J., and Liu, Y., Quaternary structure, substrate selectivity and inhibitor design for SARS 3C-like proteinase. Curr Pharm Des, 2006. 12(35): p. 4555-64._\|\|_7. Fan, K., Wei, P., Feng, Q., Chen, S., Huang, C., Ma, L., Lai, B., Pei, J., Liu, Y., Chen, J., and Lai, L., Biosynthesis, purification, and substrate specificity of severe acute respiratory syndrome coronavirus 3C-like proteinase. J Biol Chem, 2004. 279(3): p. 1637-42._\|\|_Keywords:_\|\|_3CLpro, 3C-like protease, protease, cysteine protease, coronavirus, virus, SARS, SARS-CoV, primary screen, peptide cleavage, HTS, high throughput screen, 1536, inhibitor, QFRET, quenching fluorescence resonance energy transfer, Scripps, Scripps Florida, The Scripps Research Institute Molecular Screening Center, SRIMSC, Molecular Libraries Probe Production Centers Network, MLPCN.	Due to the increasing size of the MLPCN compound library, this assay may have been run as two or more separate campaigns, each campaign testing a unique set of compounds. In this case the results of each separate campaign were assigned 'Active/Inactive' status based upon that campaign's specific compound activity cutoff value. All data reported were normalized on a per-plate basis. Possible artifacts of this assay can include, but are not limited to: dust or lint located in or on wells of the microtiter plate, compounds that modulate well fluorescence. All test compound concentrations reported above and below are nominal; the specific test concentration(s) for a particular compound may vary based upon the actual sample provided by the MLSMR.	5	The Scripps Research Institute Molecular Screening Center	3CLPRO_INH_QFRET_1536_%INH	20090501	20100615	72\|119\|191\|204\|253\|298\|303\|323\|338\|366\|460\|499\|525\|546\|588\|637\|774\|803\|864\|932\|936\|938\|1046\|1047\|1150\|1201\|1309\|1318\|1329\|1345\|1400\|1401\|1474\|1492\|1539\|1646\|1676\|1688\|1727\|1775\|1780\|1820\|1832\|1833\|1853\|1882\|1890\|1892\|1893\|1922\|1923\|1967\|1981\|1985\|1986\|2000\|2002\|2007\|2015\|2018\|2048\|2082\|2092\|2108\|2118\|2123\|2125\|2132\|2153\|2159\|2161\|2165\|2170\|2181\|2187\|2196\|2197\|2215\|2240\|2247\|2249\|2256\|2265\|2266\|2303\|2315\|2331\|2333\|2343\|2348\|2375\|2378\|2391\|2406\|2435\|2466\|2471\|2480\|2482\|2554\|2576\|2581\|2585\|2618\|2662\|2690\|2692\|2708\|2720\|2722\|2727\|2732\|2733\|2741\|2754\|2756\|2762\|2771\|2786\|2788\|2804\|2812\|2833\|2890\|2904\|2950\|2955\|2972\|2999\|3003\|3012\|3016\|3019\|3025\|3037\|3059\|3108\|3117\|3126\|3151\|3168\|3169\|3182\|3194\|3203\|3213\|3242\|3278\|3279\|3295\|3306\|3308\|3324\|3331\|3332\|3333\|3334\|3335\|3339\|3351\|3357\|3366\|3371\|3373\|3374\|3381\|3385\|3394\|3396\|3397\|3431\|3446\|3449\|3463\|3475\|3478\|3488\|3503\|3512\|3516\|3542\|3559\|3564\|3598\|3611\|3616\|3634\|3639\|3640\|3647\|3672\|3676\|3686\|3698\|3702\|3715\|3718\|3728\|3747\|3749\|3767\|3784\|3786\|3787\|3793\|3825\|3828\|3830\|3878\|3883\|3899\|3902\|3945\|3951\|3957\|3969\|4011\|4021\|4038\|4044\|4045\|4049\|4055\|4066\|4100\|4107\|4114\|4140\|4173\|4197\|4201\|4235\|4236\|4342\|4409\|4418\|4421\|4449\|4463\|4472\|4485\|4487\|4488\|4495\|4496\|4497\|4498\|4507\|4539\|4540\|4544\|4563\|4564\|4594\|4612\|4614\|4615\|4619\|4622\|4628\|4630\|4632\|4649\|4723\|4728\|4731\|4740\|4748\|4754\|4757\|4760\|4764\|4775\|4781\|4826\|4828\|4831\|4838\|4843\|4847\|4878\|4879\|4891\|4895\|4909\|4911\|4912\|4917\|4928\|4937\|4977\|4993\|5002\|5059\|5070\|5073\|5074\|5092\|5094\|5147\|5152\|5155\|5213\|5215\|5265\|5267\|5280\|5298\|5315\|5319\|5320\|5323\|5324\|5325\|5326\|5327\|5328\|5329\|5330\|5332\|5336\|5338\|5342\|5344\|5358\|5382\|5383\|5386\|5387\|5394\|5396\|5401\|5405\|5408\|5426\|5430\|5443\|5455\|5472\|5479\|5503\|5505\|5510\|5531\|5546\|5560\|5578\|5585\|5593\|5595\|5597\|5610\|5662\|5668\|5707\|5717\|5719\|5723\|5734\|5735\|5741\|5744\|5748\|5753\|5754\|5755\|5756\|5757\|5763\|5775\|5790\|5792\|5795\|5803\|5807\|5824\|5834\|5853\|5865\|5870\|5877\|5879\|5887\|5901\|5904\|5909\|5911\|5920\|5934\|5952\|5963\|5983\|5991\|5994\|6010\|6014\|6018\|6029\|6042\|6043\|6048\|6051\|6060\|6081\|6084\|6088\|6099\|6100\|6114\|6128\|6129\|6166\|6167\|6169\|6199\|6215\|6231\|6234\|6238\|6240\|6249\|6252\|6253\|6256\|6271\|6279\|6284\|6291\|6292\|6314\|6320\|6436\|6623\|6626\|6634\|6674\|6687\|6701\|6706\|6724\|6731\|6741\|6760\|6763\|6772\|6796\|6821\|6825\|6872\|6888\|7031\|7038\|7064\|7079\|7087\|7108\|7113\|7127\|7135\|7153\|7172\|7181\|7184\|7204\|7213\|7226\|7337\|7389\|7419\|7423\|7428\|7444\|7456\|7550\|7560\|7564\|7566\|7571\|7578\|7594\|7619\|8096\|8113\|8228\|8246\|8307\|8321\|8323\|8366\|8369\|8395\|8407\|8409\|8456\|8468\|8496\|8549\|8562\|8566\|8570\|8572\|8588\|8593\|8616\|8660\|8667\|8691\|8694\|8695\|8737\|8739\|8743\|8768\|8796\|8956\|8974\|8980\|9013\|9046\|9047\|9050\|9066\|9082\|9189\|9212\|9279\|9301\|9305\|9324\|9340\|9363\|9367\|9373\|9498\|9516\|9568\|9581\|9642\|9679\|9714\|9878\|9912\|10006\|10114\|10145\|10156\|10168\|10177\|10187\|10208\|10211\|10212\|10227\|10228\|10242\|10365\|10367\|10603\|10607\|10621\|10631\|10633\|10648\|10666\|10667\|10685\|10718\|10737\|10748\|10752\|10788\|10816\|10853\|10855\|11065\|11079\|11100\|11107\|11224\|11257\|11273\|11289\|11316\|11332\|11352\|11368\|11371\|11373\|11394\|11548\|11683\|11741\|11829\|11942\|11972\|11989\|12004\|12035\|12086\|12107\|12109\|12117\|12127\|12132\|12446\|12492\|12543\|12560\|12599\|12612\|12855\|12856\|12870\|12884\|12888\|12897\|12901\|12914\|13067\|13109\|13266\|13271\|13283\|13356\|13399\|13436\|13451\|13624\|13625\|13659\|13698\|13756\|13770\|13789\|13791\|13918\|14129\|14161\|14169\|14219\|14296\|14358\|14369\|14390\|14399\|14512\|14547\|14562\|14569\|14604\|14610\|14623\|14659\|14987\|15032\|15049\|15075\|15139\|15163\|15165\|15209\|15432\|15529\|15546\|15548\|15629\|15630\|15680\|15685\|15718\|15723\|15781\|15782\|15799\|15806\|15807\|15818\|15882\|16054\|16088\|16124\|16175\|16179\|16230\|16246\|16362\|16434\|16475\|16484\|16490\|16543\|16559\|16574\|16623\|16803\|16834\|17113\|17174\|17201\|17210\|17275\|17335\|17471\|17520\|17536\|17561\|17683\|17709\|17848\|17893\|18069\|18283\|18469\|18774\|18834\|18986\|19004\|19103\|19318\|19337\|19405\|19495\|19529\|19646\|19692\|19703\|19708\|19910\|20085\|20118\|20179\|20231\|20262\|20279\|20415\|20469\|20477\|20523\|20557\|20601\|20612\|20784\|20812\|20879\|20926\|20984\|20992\|21010\|21103\|21107\|21184\|21282\|21307\|21330\|21373\|21454\|21477\|21501\|21551\|21552\|21600\|21624\|21632\|21718\|21810\|21924\|22122\|22162\|22275\|22407\|22420\|22641\|22650\|22652\|22685\|22733\|22769\|22780\|22783\|22860\|22883\|23064\|23191\|23263\|23383\|23386\|23418\|2346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Initiatives	12690091\|12690092\|14561748\|15358261\|17168761\|17168763	null	AAZ82016	11120	null	null	290893	405	null	null	COVID-19\|COVID19\|Coronavirus\|Corona-virus\|SARS\|SARS2\|SARS-CoV\|SARS-CoV-2\|COVID info from BioAssay
1859	Summary	Summary of probe development efforts to identify inhibitors of the SARS coronavirus 3C-like Protease (3CLPro)	Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC)_\|\|_Center Affiliation: The Scripps Research Institute (TSRI)_\|\|_Assay Provider: Valerie Tokars and Andrew Mesecar, University of Illinois at Chicago (UIC)_\|\|_Network: Molecular Libraries Probe Production Centers Network (MLPCN)_\|\|_Grant Proposal Number: 1-R03-MH084162-01A1_\|\|_Grant Proposal PI: Valerie Tokars and Andrew Mesecar, UIC_\|\|_External Assay ID: 3CLPRO_INH_LEADS_SUMMARY_\|\|_Name: Summary of probe development efforts to identify inhibitors of the SARS coronavirus 3C-like Protease (3CLPro)_\|\|_Description: _\|\|_Coronaviruses are enveloped, large plus-strand RNA viruses that cause the common cold and other disorders such as lower respiratory tract infections and diarrhea (1). In 2003, the novel SARS coronavirus (SARS-CoV) was identified (2, 3) as the etiological agent of the global epidemic of severe acute respiratory syndrome (SARS), an atypical pneumonia that led to progressive respiratory failure in 8000 individuals and 800 deaths by July of that year (4). The SARS-CoV genome encodes a polypeptide that is proteolytically processed by two main proteases, one of which is the 3C-like protease (3CLpro). This chemotrypsin-like cysteine protease is essential for proteolytic processing of the coronavirus polyprotein and thus viral gene expression (5). The protein exists as a dimer/monomer mixture in solution and the dimer was confirmed to be the active species for the enzyme reaction (6). The current absence of a vaccine to prevent SARS infection, the possibility of future SARS epidemics, the recent cloning and expression of recombinant SARS 3CLpro (7), along with studies showing that 3CLpro is essential for viral life cycle, support a role for 3CL-pro as an important pathogenic component of SARS-CoV. The identification of specific inhibitors of 3CLpro will add insights into the biology of SARS-CoV infection of avian and mammalian cells, and serve as valuable tools for inhibiting SARS-CoV replication._\|\|_Summary of Probe Development Effort:_\|\|_Following primary HTS in singlicate to identify 3CLPro inhibitors (AID1706), compounds were identified as possible candidates for probe development. A probe development effort is currently underway at the SRIMSC._\|\|_References:_\|\|_1. Myint, S.H., Human coronavirus infections, in The Coronaviridae, S.G. Siddell, Editor. 1995, Plenum Press. p. 389-401._\|\|_2. Ksiazek, T.G., Erdman, D., Goldsmith, C.S., Zaki, S.R., Peret, T., Emery, S., Tong, S., Urbani, C., Comer, J.A., Lim, W., Rollin, P.E., Dowell, S.F., Ling, A.E., Humphrey, C.D., Shieh, W.J., Guarner, J., Paddock, C.D., Rota, P., Fields, B., DeRisi, J., Yang, J.Y., Cox, N., Hughes, J.M., LeDuc, J.W., Bellini, W.J., and Anderson, L.J., A novel coronavirus associated with severe acute respiratory syndrome. N Engl J Med, 2003. 348(20): p. 1953-66_\|\|_3. Drosten, C., Gunther, S., Preiser, W., van der Werf, S., Brodt, H.R., Becker, S., Rabenau, H., Panning, M., Kolesnikova, L., Fouchier, R.A., Berger, A., Burguiere, A.M., Cinatl, J., Eickmann, M., Escriou, N., Grywna, K., Kramme, S., Manuguerra, J.C., Muller, S., Rickerts, V., Sturmer, M., Vieth, S., Klenk, H.D., Osterhaus, A.D., Schmitz, H., and Doerr, H.W., Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N Engl J Med, 2003. 348(20): p. 1967-76._\|\|_4. Ziebuhr, J., Molecular biology of severe acute respiratory syndrome coronavirus. Curr Opin Microbiol, 2004. 7(4): p. 412-9._\|\|_5. Yang, H., Bartlam, M., and Rao, Z., Drug design targeting the main protease, the Achilles' heel of coronaviruses. Curr Pharm Des, 2006. 12(35): p. 4573-90._\|\|_6. Lai, L., Han, X., Chen, H., Wei, P., Huang, C., Liu, S., Fan, K., Zhou, L., Liu, Z., Pei, J., and Liu, Y., Quaternary structure, substrate selectivity and inhibitor design for SARS 3C-like proteinase. Curr Pharm Des, 2006. 12(35): p. 4555-64._\|\|_7. Fan, K., Wei, P., Feng, Q., Chen, S., Huang, C., Ma, L., Lai, B., Pei, J., Liu, Y., Chen, J., and Lai, L., Biosynthesis, purification, and substrate specificity of severe acute respiratory syndrome coronavirus 3C-like proteinase. J Biol Chem, 2004. 279(3): p. 1637-42._\|\|_Keywords: _\|\|_Summary AID, 3CLpro, 3C-like protease, protease, cysteine protease, coronavirus, virus, SARS, SARS-CoV, primary screen, peptide cleavage, HTS, high throughput screen, 1536, inhibitor, QFRET, quenching fluorescence resonance energy transfer, Scripps, Scripps Florida, The Scripps Research Institute Molecular Screening Center, SRIMSC, Molecular Libraries Probe Production Centers Network, MLPCN.	This probe development project is still underway at the SRIMSC.	5	The Scripps Research Institute Molecular Screening Center	3CLPRO_INH_LEADS_SUMMARY	20090709	20120327	null	null	null	null	AAZ82016	NIH Initiatives	12690091\|12690092\|14561748\|15358261\|17168761\|17168763	null	AAZ82016	11120	null	null	null	null	null	null	COVID-19\|COVID19\|Coronavirus\|Corona-virus\|SARS\|SARS2\|SARS-CoV\|SARS-CoV-2\|COVID info from BioAssay

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