### ----------------------------------------------------
### -- FHIR
### -- Licenses: Artistic-2.0
### -- Authors: Hugh Simpson
### -- File: t/resources/structureDefinition/ResearchStudy.json
### ----------------------------------------------------
### -- Chunk 6 of 8
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\" alt=\".\" style=\"background-color: white; background-color: inherit\" title=\"Data Type\" class=\"hierarchy\"/> <span title=\"ResearchStudy.objective.type : The kind of study objective.\">type</span><a name=\"ResearchStudy.objective.type\"> </a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"/><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">0..1</td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\"><a href=\"datatypes.html#CodeableConcept\">CodeableConcept</a></td><td style=\"vertical-align: top; text-align : left; background-color: white; border: 0px #F0F0F0 solid; padding:0px 4px 0px 4px\" class=\"hierarchy\">primary | secondary | exploratory<br/><a href=\"valueset-research-study-objective-type.html\" title=\"Codes for the kind of study objective.\">ResearchStudyObjectiveType</a> (<a href=\"terminologies.html#preferred\" title=\"Instances are encouraged to draw from the specified codes for interoperability purposes but are not required to do so to be considered conformant.\">Preferred</a>)</td></tr>\r\n<tr><td colspan=\"5\" class=\"hierarchy\"><br/><a href=\"formats.html#table\" title=\"Legend for this format\"><img src=\"help16.png\" alt=\"doco\" style=\"background-color: inherit\"/> Documentation for this format</a></td></tr></table></div>"
  },
  "extension" : [{
    "url" : "http://hl7.org/fhir/StructureDefinition/structuredefinition-category",
    "valueString" : "Specialized.Public Health &amp; Research"
  },
  {
    "url" : "http://hl7.org/fhir/StructureDefinition/structuredefinition-standards-status",
    "valueCode" : "trial-use"
  },
  {
    "url" : "http://hl7.org/fhir/StructureDefinition/structuredefinition-fmm",
    "valueInteger" : 0
  },
  {
    "url" : "http://hl7.org/fhir/StructureDefinition/structuredefinition-security-category",
    "valueCode" : "business"
  },
  {
    "url" : "http://hl7.org/fhir/StructureDefinition/structuredefinition-wg",
    "valueCode" : "brr"
  }],
  "url" : "http://hl7.org/fhir/StructureDefinition/ResearchStudy",
  "version" : "4.0.0",
  "name" : "ResearchStudy",
  "status" : "draft",
  "date" : "2018-12-27T22:37:54+11:00",
  "publisher" : "Health Level Seven International (Biomedical Research and Regulation)",
  "contact" : [{
    "telecom" : [{
      "system" : "url",
      "value" : "http://hl7.org/fhir"
    }]
  },
  {
    "telecom" : [{
      "system" : "url",
      "value" : "http://www.hl7.org/Special/committees/rcrim/index.cfm"
    }]
  }],
  "description" : "A process where a researcher or organization plans and then executes a series of steps intended to increase the field of healthcare-related knowledge.  This includes studies of safety, efficacy, comparative effectiveness and other information about medications, devices, therapies and other interventional and investigative techniques.  A ResearchStudy involves the gathering of information about human or animal subjects.",
  "fhirVersion" : "4.0.0",
  "mapping" : [{
    "identity" : "BRIDG5.1",
    "uri" : "https://bridgmodel.nci.nih.gov",
    "name" : "BRIDG 5.1 Mapping"
  },
  {
    "identity" : "v2",
    "uri" : "http://hl7.org/v2",
    "name" : "HL7 v2 Mapping"
  },
  {
    "identity" : "rim",
    "uri" : "http://hl7.org/v3",
    "name" : "RIM Mapping"
  },
  {
    "identity" : "clinicaltrials-gov",
    "uri" : "http://clinicaltrials.gov",
    "name" : "ClinicalTrials.gov Mapping"
  },
  {
    "identity" : "w5",
    "uri" : "http://hl7.org/fhir/fivews",
    "name" : "FiveWs Pattern Mapping"
  }],
  "kind" : "resource",
  "abstract" : false,
  "type" : "ResearchStudy",
  "baseDefinition" : "http://hl7.org/fhir/StructureDefinition/DomainResource",
  "derivation" : "specialization",
  "snapshot" : {
    "element" : [{
      "id" : "ResearchStudy",
      "path" : "ResearchStudy",
      "short" : "Investigation to increase healthcare-related patient-independent knowledge",
      "definition" : "A process where a researcher or organization plans and then executes a series of steps intended to increase the field of healthcare-related knowledge.  This includes studies of safety, efficacy, comparative effectiveness and other information about medications, devices, therapies and other interventional and investigative techniques.  A ResearchStudy involves the gathering of information about human or animal subjects.",
      "comment" : "Need to make sure we encompass public health studies.",
      "alias" : ["Clinical Trial",
      "Study"],
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "ResearchStudy",
        "min" : 0,
        "max" : "*"
      },
      "constraint" : [{
        "key" : "dom-2",
        "severity" : "error",
        "human" : "If the resource is contained in another resource, it SHALL NOT contain nested Resources",
        "expression" : "contained.contained.empty()",
        "xpath" : "not(parent::f:contained and f:contained)",
        "source" : "DomainResource"
      },
      {
        "key" : "dom-4",
        "severity" : "error",
        "human" : "If a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated",
        "expression" : "contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()",
        "xpath" : "not(exists(f:contained/*/f:meta/f:versionId)) and not(exists(f:contained/*/f:meta/f:lastUpdated))",
        "source" : "DomainResource"
      },
      {
        "key" : "dom-3",
        "severity" : "error",
        "human" : "If the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource",
        "expression" : "contained.where((('#'+id in (%resource.descendants().reference | %resource.descendants().as(canonical) | %resource.descendants().as(uri) | %resource.descendants().as(url))) or descendants().where(reference = '#').exists() or descendants().where(as(canonical) = '#').exists() or descendants().where(as(canonical) = '#').exists()).not()).trace('unmatched', id).empty()",
        "xpath" : "not(exists(for $contained in f:contained return $contained[not(parent::*/descendant::f:reference/@value=concat('#', $contained/*/id/@value) or descendant::f:reference[@value='#'])]))",
        "source" : "DomainResource"
      },
      {
        "extension" : [{
          "url" : "http://hl7.org/fhir/StructureDefinition/elementdefinition-bestpractice",
          "valueBoolean" : true
        },
        {
          "url" : "http://hl7.org/fhir/StructureDefinition/elementdefinition-bestpractice-explanation",
          "valueMarkdown" : "When a resource has no narrative, only systems that fully understand the data can display the resource to a human safely. Including a human readable representation in the resource makes for a much more robust eco-system and cheaper handling of resources by intermediary systems. Some ecosystems restrict distribution of resources to only those systems that do fully understand the resources, and as a consequence implementers may believe that the narrative is superfluous. However experience shows that such eco-systems often open up to new participants over time."
        }],
        "key" : "dom-6",
        "severity" : "warning",
        "human" : "A resource should have narrative for robust management",
        "expression" : "text.div.exists()",
        "xpath" : "exists(f:text/h:div)",
        "source" : "DomainResource"
      },
      {
        "key" : "dom-5",
        "severity" : "error",
        "human" : "If a resource is contained in another resource, it SHALL NOT have a security label",
        "expression" : "contained.meta.security.empty()",
        "xpath" : "not(exists(f:contained/*/f:meta/f:security))",
        "source" : "DomainResource"
      }],
      "isModifier" : false,
      "isSummary" : false,
      "mapping" : [{
        "identity" : "rim",
        "map" : "Entity. Role, or Act"
      },
      {
        "identity" : "BRIDG5.1",
        "map" : "ObservationalStudyProtocolVersion; Study;\nStudyProtocolVersion"
      },
      {
        "identity" : "v2",
        "map" : "OBX"
      },
      {
        "identity" : "rim",
        "map" : "Observation[classCode=CLNTRL, moodCode=EVN]"
      }]
    },
    {
      "id" : "ResearchStudy.id",
      "path" : "ResearchStudy.id",
      "short" : "Logical id of this artifact",
      "definition" : "The logical id of the resource, as used in the URL for the resource. Once assigned, this value never changes.",
      "comment" : "The only time that a resource does not have an id is when it is being submitted to the server using a create operation.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "Resource.id",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "id"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "ResearchStudy.meta",
      "path" : "ResearchStudy.meta",
      "short" : "Metadata about the resource",
      "definition" : "The metadata about the resource. This is content that is maintained by the infrastructure. Changes to the content might not always be associated with version changes to the resource.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "Resource.meta",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "Meta"
      }],
      "isModifier" : false,
      "isSummary" : true
    },
    {
      "id" : "ResearchStudy.implicitRules",
      "path" : "ResearchStudy.implicitRules",
      "short" : "A set of rules under which this content was created",
      "definition" : "A reference to a set of rules that were followed when the resource was constructed, and which must be understood when processing the content. Often, this is a reference to an implementation guide that defines the special rules along with other profiles etc.",
      "comment" : "Asserting this rule set restricts the content to be only understood by a limited set of trading partners. This inherently limits the usefulness of the data in the long term. However, the existing health eco-system is highly fractured, and not yet ready to define, collect, and exchange data in a generally computable sense. Wherever possible, implementers and/or specification writers should avoid using this element. Often, when used, the URL is a reference to an implementation guide that defines these special rules as part of it's narrative along with other profiles, value sets, etc.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "Resource.implicitRules",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "uri"
      }],
      "isModifier" : true,
      "isModifierReason" : "This element is labeled as a modifier because the implicit rules may provide additional knowledge about the resource that modifies it's meaning or interpretation",
      "isSummary" : true
    },
    {
      "id" : "ResearchStudy.language",
      "path" : "ResearchStudy.language",
      "short" : "Language of the resource content",
      "definition" : "The base language in which the resource is written.",
      "comment" : "Language is provided to support indexing and accessibility (typically, services such as text to speech use the language tag). The html language tag in the narrative applies  to the narrative. The language tag on the resource may be used to specify the language of other presentations generated from the data in the resource. Not all the content has to be in the base language. The Resource.language should not be assumed to apply to the narrative automatically. If a language is specified, it should it also be specified on the div element in the html (see rules in HTML5 for information about the relationship between xml:lang and the html lang attribute).",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "Resource.language",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "code"
      }],
      "isModifier" : false,
      "isSummary" : false,
      "binding" : {
        "extension" : [{
          "url" : "http://hl7.org/fhir/StructureDefinition/elementdefinition-maxValueSet",
          "valueCanonical" : "http://hl7.org/fhir/ValueSet/all-languages"
        },
        {
          "url" : "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString" : "Language"
        },
        {
          "url" : "http://hl7.org/fhir/StructureDefinition/elementdefinition-isCommonBinding",
          "valueBoolean" : true
        }],
        "strength" : "preferred",
        "description" : "A human language.",
        "valueSet" : "http://hl7.org/fhir/ValueSet/languages"
      }
    },
    {
      "id" : "ResearchStudy.text",
      "path" : "ResearchStudy.text",
      "short" : "Text summary of the resource, for human interpretation",
      "definition" : "A human-readable narrative that contains a summary of the resource and can be used to represent the content of the resource to a human. The narrative need not encode all the structured data, but is required to contain sufficient detail to make it \"clinically safe\" for a human to just read the narrative. Resource definitions may define what content should be represented in the narrative to ensure clinical safety.",
      "comment" : "Contained resources do not have narrative. Resources that are not contained SHOULD have a narrative. In some cases, a resource may only have text with little or no additional discrete data (as long as all minOccurs=1 elements are satisfied).  This may be necessary for data from legacy systems where information is captured as a \"text blob\" or where text is additionally entered raw or narrated and encoded information is added later.",
      "alias" : ["narrative",
      "html",
      "xhtml",
      "display"],
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "DomainResource.text",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "Narrative"
      }],
      "isModifier" : false,
      "isSummary" : false,
      "mapping" : [{
        "identity" : "rim",
        "map" : "Act.text?"
      }]
    },
    {
      "id" : "ResearchStudy.contained",
      "path" : "ResearchStudy.contained",
      "short" : "Contained, inline Resources",
      "definition" : "These resources do not have an independent existence apart from the resource that contains them - they cannot be identified independently, and nor can they have their own independent transaction scope.",
      "comment" : "This should never be done when the content can be identified properly, as once identification is lost, it is extremely difficult (and context dependent) to restore it again. Contained resources may have profiles and tags In their meta elements, but SHALL NOT have security labels.",
      "alias" : ["inline resources",
      "anonymous resources",
      "contained resources"],
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "DomainResource.contained",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "Resource"
      }],
      "isModifier" : false,
      "isSummary" : false,
      "mapping" : [{
        "identity" : "rim",
        "map" : "N/A"
      }]
    },
    {
      "id" : "ResearchStudy.extension",
      "path" : "ResearchStudy.extension",
      "short" : "Additional content defined by implementations",
      "definition" : "May be used to represent additional information that is not part of the basic definition of the resource. To make the use of extensions safe and manageable, there is a strict set of governance  applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.",
      "comment" : "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "alias" : ["extensions",
      "user content"],
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "DomainResource.extension",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "Extension"
      }],
      "isModifier" : false,
      "isSummary" : false,
      "mapping" : [{
        "identity" : "rim",
        "map" : "N/A"
      }]
    },
    {
      "id" : "ResearchStudy.modifierExtension",
      "path" : "ResearchStudy.modifierExtension",
      "short" : "Extensions that cannot be ignored",
      "definition" : "May be used to represent additional information that is not part of the basic definition of the resource and that modifies the understanding of the element that contains it and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and manageable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer is allowed to define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.\n\nModifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).",
      "comment" : "There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.",
      "requirements" : "Modifier extensions allow for extensions that *cannot* be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored.  This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the [definition of modifier extensions](extensibility.html#modifierExtension).",
      "alias" : ["extensions",
      "user content"],
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "DomainResource.modifierExtension",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "Extension"
      }],
      "isModifier" : true,
      "isModifierReason" : "Modifier extensions are expected to modify the meaning or interpretation of the resource that contains them",
      "isSummary" : false,
      "mapping" : [{
        "identity" : "rim",
        "map" : "N/A"
      }]
    },
    {
      "id" : "ResearchStudy.identifier",
      "path" : "ResearchStudy.identifier",
      "short" : "Business Identifier for study",
      "definition" : "Identifiers assigned to this research study by the sponsor or other systems.",
      "requirements" : "Allows identification of the research study as it is known by various participating systems and in a way that remains consistent across servers.",
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "ResearchStudy.identifier",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "Identifier"
      }],
      "isModifier" : false,
      "isSummary" : true,
      "mapping" : [{
        "identity" : "clinicaltrials-gov",
        "map" : "Organization's Unique Protocol ID; Secondary IDs"
      },
      {
        "identity" : "w5",
        "map" : "FiveWs.identifier"
      },
      {
        "identity" : "BRIDG5.1",
        "map" : "No BRIDG mapping (although there is  DocumentVersion.identifier > StudyProtocolDocumentVersion, this is arguably a different semantic)"
      },
      {
        "identity" : "rim",
        "map" : ".identifier"
      }]
    },
    {
      "id" : "ResearchStudy.title",
      "path" : "ResearchStudy.title",
      "short" : "Name for this study",
      "definition" : "A short, descriptive user-friendly label for the study.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "ResearchStudy.title",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "string"
      }],
      "isModifier" : false,
      "isSummary" : true,
      "mapping" : [{
        "identity" : "clinicaltrials-gov",
        "map" : "Brief Title"
      },
      {
        "identity" : "BRIDG5.1",
        "map" : "No BRIDG mapping (although there is  StudyProtocolDocumentVersionPublicTitle this is arguably a different semantic: title of a document vs title of a research study)"
      }]
    },
    {
      "id" : "ResearchStudy.protocol",
      "path" : "ResearchStudy.protocol",
      "short" : "Steps followed in executing study",
      "definition" : "The set of steps expected to be performed as part of the execution of the study.",
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "ResearchStudy.protocol",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "Reference",
        "targetProfile" : ["http://hl7.org/fhir/StructureDefinition/PlanDefinition"]
      }],
      "isModifier" : false,
      "isSummary" : true,
      "mapping" : [{
        "identity" : "clinicaltrials-gov",
        "map" : "Interventions; Arm/Intervention Cross-Reference"
      },
      {
        "identity" : "BRIDG5.1",
        "map" : "StudyProtocolDocumentVersionPublicTitle.name"
      },
      {
        "identity" : "rim",
        "map" : ".outboundRelationship[typeCode=DEFN].target"
      }]
    },
    {
      "id" : "ResearchStudy.partOf",
      "path" : "ResearchStudy.partOf",
      "short" : "Part of larger study",
      "definition" : "A larger research study of which this particular study is a component or step.",
      "requirements" : "Allows breaking a study into components (e.g. by study site) each with their own PI, status, enrollment, etc.",
      "alias" : ["container"],
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "ResearchStudy.partOf",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "Reference",
        "targetProfile" : ["http://hl7.org/fhir/StructureDefinition/ResearchStudy"]
      }],
      "isModifier" : false,
      "isSummary" : true,
      "mapping" : [{
        "identity" : "BRIDG5.1",
        "map" : "CompanionStudyRelationship"
      },
      {
        "identity" : "rim",
        "map" : ".inboundRelationship[typeCode=COMP].source[moodCode=EVN]"
      }]
    },
    {
      "id" : "ResearchStudy.status",
      "path" : "ResearchStudy.status",
      "short" : "active | administratively-completed | approved | closed-to-accrual | closed-to-accrual-and-intervention | completed | disapproved | in-review | temporarily-closed-to-accrual | temporarily-closed-to-accrual-and-intervention | withdrawn",
      "definition" : "The current state of the study.",
      "min" : 1,
      "max" : "1",
      "base" : {
        "path" : "ResearchStudy.status",
        "min" : 1,
        "max" : "1"
      },
      "type" : [{
        "code" : "code"
      }],
      "isModifier" : true,
      "isModifierReason" : "This element is labeled as a modifier because it is a status element that contains status entered-in-error which means that the resource should not be treated as valid",
      "isSummary" : true,
      "binding" : {
        "extension" : [{
          "url" : "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString" : "ResearchStudyStatus"
        }],
        "strength" : "required",
        "description" : "Codes that convey the current status of the research study.",
        "valueSet" : "http://hl7.org/fhir/ValueSet/research-study-status|4.0.0"
      },
      "mapping" : [{
        "identity" : "w5",
        "map" : "FiveWs.status"
      },
      {
        "identity" : "BRIDG5.1",
        "map" : "StudyOverallStatus.code"
      },
      {
        "identity" : "rim",
        "map" : ".status"
      }]
    },
    {
      "id" : "ResearchStudy.primaryPurposeType",
      "path" : "ResearchStudy.primaryPurposeType",
      "short" : "treatment | prevention | diagnostic | supportive-care | screening | health-services-research | basic-science | device-feasibility",
      "definition" : "The type of study based upon the intent of the study's activities. A classification of the intent of the study.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "ResearchStudy.primaryPurposeType",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isModifier" : false,
      "isSummary" : true,
      "binding" : {
        "extension" : [{
          "url" : "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString" : "ResearchStudyPrimaryPurposeType"
        }],
        "strength" : "extensible",
        "description" : "Codes for the main intent of the study.",
        "valueSet" : "http://hl7.org/fhir/ValueSet/research-study-prim-purp-type"
      },
      "mapping" : [{
        "identity" : "BRIDG5.1",
        "map" : "StudyProtocolVersion.primaryPurposeTypeCode"
      }]
    },
    {
      "id" : "ResearchStudy.phase",
      "path" : "ResearchStudy.phase",
      "short" : "n-a | early-phase-1 | phase-1 | phase-1-phase-2 | phase-2 | phase-2-phase-3 | phase-3 | phase-4",
      "definition" : "The stage in the progression of a therapy from initial experimental use in humans in clinical trials to post-market evaluation.",
      "min" : 0,
      "max" : "1",
      "base" : {
        "path" : "ResearchStudy.phase",
        "min" : 0,
        "max" : "1"
      },
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isModifier" : false,
      "isSummary" : true,
      "binding" : {
        "extension" : [{
          "url" : "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString" : "ResearchStudyPhase"
        }],
        "strength" : "example",
        "description" : "Codes for the stage in the progression of a therapy from initial experimental use in humans in clinical trials to post-market evaluation.",
        "valueSet" : "http://hl7.org/fhir/ValueSet/research-study-phase"
      },
      "mapping" : [{
        "identity" : "clinicaltrials-gov",
        "map" : "Study Phase"
      },
      {
        "identity" : "BRIDG5.1",
        "map" : "StudyProtocolVersion.phaseCode"
      }]
    },
    {
      "id" : "ResearchStudy.category",
      "path" : "ResearchStudy.category",
      "short" : "Classifications for the study",
      "definition" : "Codes categorizing the type of study such as investigational vs. observational, type of blinding, type of randomization, safety vs. efficacy, etc.",
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "ResearchStudy.category",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isModifier" : false,
      "isSummary" : true,
      "binding" : {
        "extension" : [{
          "url" : "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString" : "ResearchStudyCategory"
        }],
        "strength" : "example",
        "description" : "Codes that describe the type of research study.  E.g. Study phase, Interventional/Observational, blinding type, etc."
      },
      "mapping" : [{
        "identity" : "clinicaltrials-gov",
        "map" : "Study Type; Primary Purpose; Interventional Model; Masking; Allocation; study Classification; Observational Study Model; Time Perspective; Biospecimen Retention"
      },
      {
        "identity" : "BRIDG5.1",
        "map" : "InterventionalStudyProtocolVersion; InterventionalStudyProtocol.allocationCode; InterventionalStudyProtocol.blindedRoleCode; InterventionalStudyProtocol.blindingSchemaCode; InterventionalStudyProtocol.controlTypeCode"
      }]
    },
    {
      "id" : "ResearchStudy.focus",
      "path" : "ResearchStudy.focus",
      "short" : "Drugs, devices, etc. under study",
      "definition" : "The medication(s), food(s), therapy(ies), device(s) or other concerns or interventions that the study is seeking to gain more information about.",
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "ResearchStudy.focus",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "isModifier" : false,
      "isSummary" : true,
      "binding" : {
        "extension" : [{
          "url" : "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString" : "ResearchStudyFocus"
        }],
        "strength" : "example",
        "description" : "Codes for medications, devices and other interventions."
      },
      "mapping" : [{
        "identity" : "clinicaltrials-gov",
        "map" : "Focus of Study"
      },
      {
        "identity" : "w5",
        "map" : "FiveWs.what[x]"
      },
      {
        "identity" : "BRIDG5.1",
        "map" : "InterventionalStudyProtocol.interventionTypeCode"
      }]
    },
    {
      "id" : "ResearchStudy.condition",
      "path" : "ResearchStudy.condition",
      "short" : "Condition being studied",
      "definition" : "The condition that is the focus of the study.  For example, In a study to examine risk factors for Lupus, might have as an inclusion criterion \"healthy volunteer\", but the target condition code would be a Lupus SNOMED code.",
      "min" : 0,
      "max" : "*",
      "base" : {
        "path" : "ResearchStudy.condition",
        "min" : 0,
        "max" : "*"
      },
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "is