### ----------------------------------------------------
### -- FHIR
### -- Licenses: Artistic-2.0
### -- Authors: Hugh Simpson
### -- File: t/resources/structureDefinition/EffectEvidenceSynthesis.json
### ----------------------------------------------------
### -- Chunk 14 of 14
 are expected to be used instead.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "Period"
      }],
      "isSummary" : true,
      "mapping" : [{
        "identity" : "workflow",
        "map" : "Definition.effectivePeriod"
      },
      {
        "identity" : "objimpl",
        "map" : "no-gen-base"
      }]
    },
    {
      "id" : "EffectEvidenceSynthesis.topic",
      "path" : "EffectEvidenceSynthesis.topic",
      "short" : "The category of the EffectEvidenceSynthesis, such as Education, Treatment, Assessment, etc.",
      "definition" : "Descriptive topics related to the content of the EffectEvidenceSynthesis. Topics provide a high-level categorization grouping types of EffectEvidenceSynthesiss that can be useful for filtering and searching.",
      "requirements" : "Repositories must be able to determine how to categorize the EffectEvidenceSynthesis so that it can be found by topical searches.",
      "min" : 0,
      "max" : "*",
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "binding" : {
        "extension" : [{
          "url" : "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString" : "DefinitionTopic"
        }],
        "strength" : "example",
        "description" : "High-level categorization of the definition, used for searching, sorting, and filtering.",
        "valueSet" : "http://hl7.org/fhir/ValueSet/definition-topic"
      }
    },
    {
      "id" : "EffectEvidenceSynthesis.author",
      "path" : "EffectEvidenceSynthesis.author",
      "short" : "Who authored the content",
      "definition" : "An individiual or organization primarily involved in the creation and maintenance of the content.",
      "min" : 0,
      "max" : "*",
      "type" : [{
        "code" : "ContactDetail"
      }],
      "mapping" : [{
        "identity" : "rim",
        "map" : ".participation[typeCode=AUT]"
      }]
    },
    {
      "id" : "EffectEvidenceSynthesis.editor",
      "path" : "EffectEvidenceSynthesis.editor",
      "short" : "Who edited the content",
      "definition" : "An individual or organization primarily responsible for internal coherence of the content.",
      "min" : 0,
      "max" : "*",
      "type" : [{
        "code" : "ContactDetail"
      }]
    },
    {
      "id" : "EffectEvidenceSynthesis.reviewer",
      "path" : "EffectEvidenceSynthesis.reviewer",
      "short" : "Who reviewed the content",
      "definition" : "An individual or organization primarily responsible for review of some aspect of the content.",
      "min" : 0,
      "max" : "*",
      "type" : [{
        "code" : "ContactDetail"
      }],
      "mapping" : [{
        "identity" : "rim",
        "map" : ".participation[typeCode=VRF] {not clear whether VRF best corresponds to reviewer or endorser}"
      }]
    },
    {
      "id" : "EffectEvidenceSynthesis.endorser",
      "path" : "EffectEvidenceSynthesis.endorser",
      "short" : "Who endorsed the content",
      "definition" : "An individual or organization responsible for officially endorsing the content for use in some setting.",
      "min" : 0,
      "max" : "*",
      "type" : [{
        "code" : "ContactDetail"
      }],
      "mapping" : [{
        "identity" : "rim",
        "map" : ".participation[typeCode=VRF] {not clear whether VRF best corresponds to reviewer or endorser}"
      }]
    },
    {
      "id" : "EffectEvidenceSynthesis.relatedArtifact",
      "path" : "EffectEvidenceSynthesis.relatedArtifact",
      "short" : "Additional documentation, citations, etc.",
      "definition" : "Related artifacts such as additional documentation, justification, or bibliographic references.",
      "comment" : "Each related artifact is either an attachment, or a reference to another resource, but not both.",
      "requirements" : "EffectEvidenceSynthesiss must be able to provide enough information for consumers of the content (and/or interventions or results produced by the content) to be able to determine and understand the justification for and evidence in support of the content.",
      "min" : 0,
      "max" : "*",
      "type" : [{
        "code" : "RelatedArtifact"
      }]
    },
    {
      "id" : "EffectEvidenceSynthesis.synthesisType",
      "path" : "EffectEvidenceSynthesis.synthesisType",
      "short" : "Type of synthesis",
      "definition" : "Type of synthesis eg meta-analysis.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "binding" : {
        "extension" : [{
          "url" : "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString" : "SynthesisType"
        }],
        "strength" : "extensible",
        "description" : "Types of combining results from a body of evidence (eg. summary data meta-analysis).",
        "valueSet" : "http://hl7.org/fhir/ValueSet/synthesis-type"
      }
    },
    {
      "id" : "EffectEvidenceSynthesis.studyType",
      "path" : "EffectEvidenceSynthesis.studyType",
      "short" : "Type of study",
      "definition" : "Type of study eg randomized trial.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "binding" : {
        "extension" : [{
          "url" : "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString" : "StudyType"
        }],
        "strength" : "extensible",
        "description" : "Types of research studies (types of research methods).",
        "valueSet" : "http://hl7.org/fhir/ValueSet/study-type"
      }
    },
    {
      "id" : "EffectEvidenceSynthesis.population",
      "path" : "EffectEvidenceSynthesis.population",
      "short" : "What population?",
      "definition" : "A reference to a EvidenceVariable resource that defines the population for the research.",
      "min" : 1,
      "max" : "1",
      "type" : [{
        "code" : "Reference",
        "targetProfile" : ["http://hl7.org/fhir/StructureDefinition/EvidenceVariable"]
      }],
      "isSummary" : true
    },
    {
      "id" : "EffectEvidenceSynthesis.exposure",
      "path" : "EffectEvidenceSynthesis.exposure",
      "short" : "What exposure?",
      "definition" : "A reference to a EvidenceVariable resource that defines the exposure for the research.",
      "min" : 1,
      "max" : "1",
      "type" : [{
        "code" : "Reference",
        "targetProfile" : ["http://hl7.org/fhir/StructureDefinition/EvidenceVariable"]
      }],
      "isSummary" : true
    },
    {
      "id" : "EffectEvidenceSynthesis.exposureAlternative",
      "path" : "EffectEvidenceSynthesis.exposureAlternative",
      "short" : "What comparison exposure?",
      "definition" : "A reference to a EvidenceVariable resource that defines the comparison exposure for the research.",
      "min" : 1,
      "max" : "1",
      "type" : [{
        "code" : "Reference",
        "targetProfile" : ["http://hl7.org/fhir/StructureDefinition/EvidenceVariable"]
      }],
      "isSummary" : true
    },
    {
      "id" : "EffectEvidenceSynthesis.outcome",
      "path" : "EffectEvidenceSynthesis.outcome",
      "short" : "What outcome?",
      "definition" : "A reference to a EvidenceVariable resomece that defines the outcome for the research.",
      "min" : 1,
      "max" : "1",
      "type" : [{
        "code" : "Reference",
        "targetProfile" : ["http://hl7.org/fhir/StructureDefinition/EvidenceVariable"]
      }],
      "isSummary" : true
    },
    {
      "id" : "EffectEvidenceSynthesis.sampleSize",
      "path" : "EffectEvidenceSynthesis.sampleSize",
      "short" : "What sample size was involved?",
      "definition" : "A description of the size of the sample involved in the synthesis.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "BackboneElement"
      }]
    },
    {
      "id" : "EffectEvidenceSynthesis.sampleSize.description",
      "path" : "EffectEvidenceSynthesis.sampleSize.description",
      "short" : "Description of sample size",
      "definition" : "Human-readable summary of sample size.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "string"
      }]
    },
    {
      "id" : "EffectEvidenceSynthesis.sampleSize.numberOfStudies",
      "path" : "EffectEvidenceSynthesis.sampleSize.numberOfStudies",
      "short" : "How many studies?",
      "definition" : "Number of studies included in this evidence synthesis.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "integer"
      }]
    },
    {
      "id" : "EffectEvidenceSynthesis.sampleSize.numberOfParticipants",
      "path" : "EffectEvidenceSynthesis.sampleSize.numberOfParticipants",
      "short" : "How many participants?",
      "definition" : "Number of participants included in this evidence synthesis.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "integer"
      }]
    },
    {
      "id" : "EffectEvidenceSynthesis.resultsByExposure",
      "path" : "EffectEvidenceSynthesis.resultsByExposure",
      "short" : "What was the result per exposure?",
      "definition" : "A description of the results for each exposure considered in the effect estimate.",
      "min" : 0,
      "max" : "*",
      "type" : [{
        "code" : "BackboneElement"
      }]
    },
    {
      "id" : "EffectEvidenceSynthesis.resultsByExposure.description",
      "path" : "EffectEvidenceSynthesis.resultsByExposure.description",
      "short" : "Description of results by exposure",
      "definition" : "Human-readable summary of results by exposure state.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "string"
      }]
    },
    {
      "id" : "EffectEvidenceSynthesis.resultsByExposure.exposureState",
      "path" : "EffectEvidenceSynthesis.resultsByExposure.exposureState",
      "short" : "exposure | exposure-alternative",
      "definition" : "Whether these results are for the exposure state or alternative exposure state.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "code"
      }],
      "binding" : {
        "extension" : [{
          "url" : "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString" : "ExposureState"
        }],
        "strength" : "required",
        "description" : "Whether the results by exposure is describing the results for the primary exposure of interest (exposure) or the alternative state (exposureAlternative).",
        "valueSet" : "http://hl7.org/fhir/ValueSet/exposure-state|4.0.0"
      }
    },
    {
      "id" : "EffectEvidenceSynthesis.resultsByExposure.variantState",
      "path" : "EffectEvidenceSynthesis.resultsByExposure.variantState",
      "short" : "Variant exposure states",
      "definition" : "Used to define variant exposure states such as low-risk state.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "binding" : {
        "extension" : [{
          "url" : "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString" : "EvidenceVariantState"
        }],
        "strength" : "extensible",
        "description" : "Used for results by exposure in variant states such as low-risk, medium-risk and high-risk states.",
        "valueSet" : "http://hl7.org/fhir/ValueSet/evidence-variant-state"
      }
    },
    {
      "id" : "EffectEvidenceSynthesis.resultsByExposure.riskEvidenceSynthesis",
      "path" : "EffectEvidenceSynthesis.resultsByExposure.riskEvidenceSynthesis",
      "short" : "Risk evidence synthesis",
      "definition" : "Reference to a RiskEvidenceSynthesis resource.",
      "min" : 1,
      "max" : "1",
      "type" : [{
        "code" : "Reference",
        "targetProfile" : ["http://hl7.org/fhir/StructureDefinition/RiskEvidenceSynthesis"]
      }]
    },
    {
      "id" : "EffectEvidenceSynthesis.effectEstimate",
      "path" : "EffectEvidenceSynthesis.effectEstimate",
      "short" : "What was the estimated effect",
      "definition" : "The estimated effect of the exposure variant.",
      "min" : 0,
      "max" : "*",
      "type" : [{
        "code" : "BackboneElement"
      }],
      "isSummary" : true
    },
    {
      "id" : "EffectEvidenceSynthesis.effectEstimate.description",
      "path" : "EffectEvidenceSynthesis.effectEstimate.description",
      "short" : "Description of effect estimate",
      "definition" : "Human-readable summary of effect estimate.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "string"
      }]
    },
    {
      "id" : "EffectEvidenceSynthesis.effectEstimate.type",
      "path" : "EffectEvidenceSynthesis.effectEstimate.type",
      "short" : "Type of efffect estimate",
      "definition" : "Examples include relative risk and mean difference.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "binding" : {
        "extension" : [{
          "url" : "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString" : "EffectEstimateType"
        }],
        "strength" : "extensible",
        "description" : "Whether the effect estimate is an absolute effect estimate (absolute difference) or a relative effect estimate (relative difference), and the specific type of effect estimate (eg relative risk or median difference).",
        "valueSet" : "http://hl7.org/fhir/ValueSet/effect-estimate-type"
      }
    },
    {
      "id" : "EffectEvidenceSynthesis.effectEstimate.variantState",
      "path" : "EffectEvidenceSynthesis.effectEstimate.variantState",
      "short" : "Variant exposure states",
      "definition" : "Used to define variant exposure states such as low-risk state.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "binding" : {
        "extension" : [{
          "url" : "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString" : "EvidenceVariantState"
        }],
        "strength" : "extensible",
        "description" : "Used for results by exposure in variant states such as low-risk, medium-risk and high-risk states.",
        "valueSet" : "http://hl7.org/fhir/ValueSet/evidence-variant-state"
      }
    },
    {
      "id" : "EffectEvidenceSynthesis.effectEstimate.value",
      "path" : "EffectEvidenceSynthesis.effectEstimate.value",
      "short" : "Point estimate",
      "definition" : "The point estimate of the effect estimate.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "decimal"
      }]
    },
    {
      "id" : "EffectEvidenceSynthesis.effectEstimate.unitOfMeasure",
      "path" : "EffectEvidenceSynthesis.effectEstimate.unitOfMeasure",
      "short" : "What unit is the outcome described in?",
      "definition" : "Specifies the UCUM unit for the outcome.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "binding" : {
        "extension" : [{
          "url" : "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString" : "UCUMUnits"
        }],
        "strength" : "required",
        "description" : "Unified Code for Units of Measure (UCUM).",
        "valueSet" : "http://hl7.org/fhir/ValueSet/ucum-units|4.0.0"
      }
    },
    {
      "id" : "EffectEvidenceSynthesis.effectEstimate.precisionEstimate",
      "path" : "EffectEvidenceSynthesis.effectEstimate.precisionEstimate",
      "short" : "How precise the estimate is",
      "definition" : "A description of the precision of the estimate for the effect.",
      "min" : 0,
      "max" : "*",
      "type" : [{
        "code" : "BackboneElement"
      }]
    },
    {
      "id" : "EffectEvidenceSynthesis.effectEstimate.precisionEstimate.type",
      "path" : "EffectEvidenceSynthesis.effectEstimate.precisionEstimate.type",
      "short" : "Type of precision estimate",
      "definition" : "Examples include confidence interval and interquartile range.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "binding" : {
        "extension" : [{
          "url" : "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString" : "PrecisionEstimateType"
        }],
        "strength" : "extensible",
        "description" : "Method of reporting variability of estimates, such as confidence intervals, interquartile range or standard deviation.",
        "valueSet" : "http://hl7.org/fhir/ValueSet/precision-estimate-type"
      }
    },
    {
      "id" : "EffectEvidenceSynthesis.effectEstimate.precisionEstimate.level",
      "path" : "EffectEvidenceSynthesis.effectEstimate.precisionEstimate.level",
      "short" : "Level of confidence interval",
      "definition" : "Use 95 for a 95% confidence interval.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "decimal"
      }]
    },
    {
      "id" : "EffectEvidenceSynthesis.effectEstimate.precisionEstimate.from",
      "path" : "EffectEvidenceSynthesis.effectEstimate.precisionEstimate.from",
      "short" : "Lower bound",
      "definition" : "Lower bound of confidence interval.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "decimal"
      }]
    },
    {
      "id" : "EffectEvidenceSynthesis.effectEstimate.precisionEstimate.to",
      "path" : "EffectEvidenceSynthesis.effectEstimate.precisionEstimate.to",
      "short" : "Upper bound",
      "definition" : "Upper bound of confidence interval.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "decimal"
      }]
    },
    {
      "id" : "EffectEvidenceSynthesis.certainty",
      "path" : "EffectEvidenceSynthesis.certainty",
      "short" : "How certain is the effect",
      "definition" : "A description of the certainty of the effect estimate.",
      "min" : 0,
      "max" : "*",
      "type" : [{
        "code" : "BackboneElement"
      }]
    },
    {
      "id" : "EffectEvidenceSynthesis.certainty.rating",
      "path" : "EffectEvidenceSynthesis.certainty.rating",
      "short" : "Certainty rating",
      "definition" : "A rating of the certainty of the effect estimate.",
      "min" : 0,
      "max" : "*",
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "binding" : {
        "extension" : [{
          "url" : "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString" : "QualityOfEvidenceRating"
        }],
        "strength" : "extensible",
        "description" : "The quality of the evidence described. The code system used specifies the quality scale used to grade this evidence source while the code specifies the actual quality score (represented as a coded value) associated with the evidence.",
        "valueSet" : "http://hl7.org/fhir/ValueSet/evidence-quality"
      }
    },
    {
      "id" : "EffectEvidenceSynthesis.certainty.note",
      "path" : "EffectEvidenceSynthesis.certainty.note",
      "short" : "Used for footnotes or explanatory notes",
      "definition" : "A human-readable string to clarify or explain concepts about the resource.",
      "min" : 0,
      "max" : "*",
      "type" : [{
        "code" : "Annotation"
      }]
    },
    {
      "id" : "EffectEvidenceSynthesis.certainty.certaintySubcomponent",
      "path" : "EffectEvidenceSynthesis.certainty.certaintySubcomponent",
      "short" : "A component that contributes to the overall certainty",
      "definition" : "A description of a component of the overall certainty.",
      "min" : 0,
      "max" : "*",
      "type" : [{
        "code" : "BackboneElement"
      }]
    },
    {
      "id" : "EffectEvidenceSynthesis.certainty.certaintySubcomponent.type",
      "path" : "EffectEvidenceSynthesis.certainty.certaintySubcomponent.type",
      "short" : "Type of subcomponent of certainty rating",
      "definition" : "Type of subcomponent of certainty rating.",
      "min" : 0,
      "max" : "1",
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "binding" : {
        "extension" : [{
          "url" : "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString" : "CertaintySubcomponentType"
        }],
        "strength" : "extensible",
        "description" : "The subcomponent classification of quality of evidence rating systems.",
        "valueSet" : "http://hl7.org/fhir/ValueSet/certainty-subcomponent-type"
      }
    },
    {
      "id" : "EffectEvidenceSynthesis.certainty.certaintySubcomponent.rating",
      "path" : "EffectEvidenceSynthesis.certainty.certaintySubcomponent.rating",
      "short" : "Subcomponent certainty rating",
      "definition" : "A rating of a subcomponent of rating certainty.",
      "min" : 0,
      "max" : "*",
      "type" : [{
        "code" : "CodeableConcept"
      }],
      "binding" : {
        "extension" : [{
          "url" : "http://hl7.org/fhir/StructureDefinition/elementdefinition-bindingName",
          "valueString" : "CertaintySubcomponentRating"
        }],
        "strength" : "extensible",
        "description" : "The quality rating of the subcomponent of a quality of evidence rating.",
        "valueSet" : "http://hl7.org/fhir/ValueSet/certainty-subcomponent-rating"
      }
    },
    {
      "id" : "EffectEvidenceSynthesis.certainty.certaintySubcomponent.note",
      "path" : "EffectEvidenceSynthesis.certainty.certaintySubcomponent.note",
      "short" : "Used for footnotes or explanatory notes",
      "definition" : "A human-readable string to clarify or explain concepts about the resource.",
      "min" : 0,
      "max" : "*",
      "type" : [{
        "code" : "Annotation"
      }]
    }]
  }
}


