True in alcoholic liver disease
Gynaecomastia is a marker of liver cell failure (not portal hypertension). 
 
The AST/ALT ratio is >2 in alcoholism as the ALT levels do not rise as much as AST due to pyridoxyl deficiency in alcohol abuse.  
 
HCV potentiates alcohol related liver damage. 
 
The CAGE questionnaire is used to diagnose alcohol related problems. 
 
Fagenstrom’s questionnaire is used to quantify addiction to nicotine in smokers.