True about wound healing
• Epidermal appendages do not regenerate
• There remains a connective tissue scar in place of the mechanically efficient meshwork of collagen in the unwounded dermis.
• Very superficial wounds: Little scar formation.
• In marked contrast with wound healing in adults, fetal cutaneous wounds heal without scar formation, up to mid-gestation age in some animals. These wounds show little inflammation and practically no fibrosis.
Cutaneous wound healing is divided into three phases
• Inflammation (early and late)
• Granulation tissue formation and re-epithelialization
• Wound contraction, ECM deposition and remodeling