False regarding Alzheimer's disease (AD) is:
Please remember that the neuropathological diagnosis of Alzheimer's disease requires extensive presence of both senile plaques (extra cellular deposits) and neurofibrillary tangles (intracellular inclusion) Alzheimer's disease: Pathophysiological Findings: Diffuse atrophy, Flattened Coical Sulci & Dilated Cerebral ventricles * Primarily involve Parietal and temporal Lobes * Atrophy stas In Medical Temporal Lobe (Entorhinal/Perirhinal Coex & Hippocampus) and spreads to Lateral & Medial parietal Lobes, Lateral Temporal Lobes & Lateral Frontal Coex Microscopic Findings: 1) Senile plaques or Neuritic plaques or Amyloid plaques Extracellular in location Ab protein 2) Neurofibrillary Tangles: Intracellular Deposits Tau proteins Neuropathological Diagnosis of AD : Extensive presence of both Senile plaques & NFT 3) Granulovacuolar Degeneration & Hirano bodies (Eosinophilic Inclusions) - Abnormalities In Cytoplasm of Hippocampal Neurons Can be present in Elderly without dementia's