A patient with recurrent bacterial infections is diagnosed to have a genetic deficiency in myeloperoxidase. The cause of increased susceptibility to infections is -
Ans. is 'c' i.e., An inability to produce hydroxyhalide redicalso Myeloperoxidase in the presence of halide (C1 ) conves H202 to hypochlorite (HOCI). HOCI is a potent microbicidal agent that destroys microbes by halogenation or by oxidation of lipids and proteins. The H202 myeloperoxidase halide system is the most efficient bactericidal system in neutrophils.