true about cox2 are all except
Cox 2 is constitutively active within kidney endothelium and brain recommended doses of Cox 2 inhibitors cause renal toxicity is similar to those associated with other NSAIDS Cox 2 inhibitors have been shown to have less gastrointestinal Side Effects because cox1 is mainly involved in protection from gastric ulcer Constitutive Cox 1 isoform tend to have housekeeping in function while Cox 2 is induced during inflammation Cox have role in synthesis of prostaglandins from architonic acid prostaglandins have 20 carbon fatty acids containing cyclopentane ring Selective Cox 2 inhibitors increase the risk of myocardial infraction Refer kDT 6/e p178