All of the following statements about hormone replacement therapy (H) are true except ?
Ans. is 'd' i.e., It increases the risk of endometrial carcinoma Hormone replacement therapy increases the risk of MI (coronary aery disease). The increased risk is attributed to progestin component. o H restore Ca++ balance, fuher bone loss is prevented and the excess fracture risk is nullified. o There is a higher incidence of breast cancer. o Risk for endometrial carcinoma is not increased as protective effect of progestin nullify the carcinogenic effect of estrogen. o There is increased risk for gall stone and migraine. o There is a small protective effective of H on colorectal cancer. Note :? o Usually in H combination of estrogen and progestin is given (combined H), except in hysterectimized women where estrogen alone is given. o With estrogen alone there is increased risk of endometrial cancer and decrease risk of coronary aery disease (as estrogen increases HDL and decreases LDL and triglyceride level). o So for H with estrogen alone the answer of this question will change. In that case it will be option 'a' i.e., increased risk of coronary aery disease.