What is false regarding McDonald criteria for diagnosis of MS?
Ans DThe McDonald Criteria incorporates clinical evaluation with magnetic resonance imaging (MRI) scans in establishing MS:* Evidence of damage to the central nervous system (CNS; the brain, spinal cord and optic nerves) that is "disseminated in time," meaning damage that occurs on different dates;* Evidence of damage "disseminated in space," or found on two or more parts of the CNS.A 2010 revision to the McDonald Criteria (which followed a 2005 update) reflected better understanding of MS and improved MRI techniques and made possible a faster diagnosis -- one that is, for a first time, potentially based on only one demyelinating relapse or attack provided certain criteria are met. These new criteria are dissemination in time, if two lesions are evident at a first attack, and dissemination in both time and space if only one lesion is evident. Oligoclonal bands should be present in CSF and not serum in diagnosis of multiple sclerosis.