A PATIENT ON LITHIUM THERAPY DEVELOPED HTN,HE WAS STAED ON THIAZIDES FOR HYPEENSION .AFTER FEW DAYS HE DEVELOPED COARSE TREMORS AND OTHER SYMPTOMS SUGGESTIVE OF LITHIUM TOXICITY .EXPLAIN THE LIKELY MECHANISM ::
DRUG INTERACTION OF LITHIUM : THIAZIDE DIURETICS INCREASE THE LITHIUM TOXICITY LOOP DIURETICS AND K+ SPARING DIURETICS -- NORMAL OR INC. LITHIUM OSMOTIC DIURETICS AND CARBONIC ANHYDRASE INHIBITORS WILL DECREASE THE LITHIUM LEVELS. REF : KD TRIPATHI 8TH ED