Which of the following statements is true about steady state?
Steady state is achieved when rate of administration is equal to rate of elimination Three impoant points to remember: Steady state is achieved within 4-5 half lives Dosing rate (dose per unit time) determines the average plasma concentration obtained at steady state. Frequency - drug when given intermittently, concentration will vary around baseline - peak and trough are obtained Longer interval - difference between peak and trough is more Lesser the interval - difference between peak and trough is less