Which of the following statements about the fluoroquinolones is FALSE?
* Fluoroquinolones are contra-indicated in children (due to risk of cailage damage) and pregnant female. * Most common mode of resistance to fluoroquinolones is mutation in DNA gyrase. * Dose of fluoroquinolones should be adjusted in renal failure (except moxifloxacin and trovafloxacin). * These drugs act by inhibiting DNA gyrase.