Mechanism of action of atropine in treatment of organophophate poisoning is?
Organophosphates AcHE inhibitors (acetylcholine cannot be broken) Level of acetyl choline increases Stimulate nicotinic & muscarinic receptors Over activity of M1- acidity M2- bradycardia M3- bronchoconstriction, secretion, diarrhea & urination Atropine is DOC for organophosphate poisoning But atropine doesn't block the nicotinic receptors (muscle weakness)