Which of the following statement is not true about NSAIDs
Acetylsalicylic acid (asprin) is an Irreversible inhibition of COX enzyme. IT results in inhibition of prostaglandin and TX synthesis at low doses for (40 to 325 milligrams) it exes antiplatelet action. this drug shows saturation kinetics at high doses that is kinetics changes from first order to zero order. therefore at high doses amount of drug exeed will be constant that means clearance il is not constant. Refer kDT 6/e p185