Drug excretion through kidney depends on all, EXCEPT
Ans. is 'b' molecular weight of the drug The amount of drug excreted by the kidney depends on 3 factors:- Glomerular filtration, tubular reabsorption, tubular secretion.Glomerular filtrationIt depends upon Plasma protein binding - Only unbound form is excreted. Renal blood flow - G.F.R. increase with increase in renal blood flow.Tubular reabsorptionThis depends uponLipid solubility of the drug - Nonlipid soluble drugs are excreted more Ionization of the drug - highly ionized drugs are excreted moreTubular secretionIt is the active transfer of organic acids and bases by two separate nonspecific mechanisms