Dr. Shweta decided to add a progestin for 10-12 days each month to estrogen replacement therapy in menopausal women in the gynaecology OPD. Addition of progestin is recommended because the progestin:
Use of estrogen for the treatment or prevention of post-menopausal osteoporosis --> increase risk of breast and endometrial carcinoma. Progesterone is used to decrease the risk of endometrial carcinoma.