All are true about Bater syndrome except?
The defect in Bater syndrome in thick ascending limb of Loop of Henle- | urinary loss of calcium & nephrocalcinosis The salt wasting and polyuria lead to dehydration- stimulates the R.A.A.S- secondary hyperaldosteronism. This explains the hypokalemia. ROMK receptors in TAL are affected leading to urinary loss of potassium. | intra-renal prostaglandins and hence indomethacin is prescribed Secondary aldosteronism explains the development of metabolic alkalosis