Concerning the central chemoreceptors, True is:
The central chemoreceptors are located near the ventral surface of the medulla; They do not respond to the PO2 of blood; for a given rise in PCO2 , The CSF pH falls more than that of blood because the CSF has less buffering. The bicarbonate concentration of the CSF can affect the output of the Central Chemoreceptors by buffering the changes in pH.