Which of the following is not true about plasma protein binding?
Ans. is 'c' i.e., There is no effect of nephrotic syndrome on plasma protein binding Plasma protein binding* Many natural substances circulate around the body partly free in plasma water and partly bound to plasma proteins, e.g. cortisol, thyroxine.* Similarly drugs circulate in protein bound and free states, and the significance is that the free fraction is pharmacologically active whereas the protein bound component is a reservoir of drug that is inactive because of this binding.* Acidic drugs generally bind to plasma albumin.* Basic drugs bind to al acid glycoprotein.* Binding to albumin is quantitatively more important.Drugs bound to plasma protein To albumin To a, acid glycoprotein* Barbiturates * Penicillins* b- blockers* Methadone* Benzodiazepines (Diazepam)* Sulfonamides* Bupivacaine* Prazosin* NSAIDS * Tetracyclines* Lignocaine* Quinidine* Valproate * Tolbutamide* Disopyramide* Verapamil* Phenytoin * Warfarin* Imipramine * In nephrotic syndrome and other conditions causing hypoproteinemia, protein binding will be altered.* Morphine is not a plasma protein bound drug ->> in nephrotic syndrome there is no effect on protein binding.