Gotta think of it in proper terms... In HeroSystem if you take disadvantages for something like a personality change, it's something the<strong>DM</strong>could use or could pull up during a scene to make it more interesting; Being<em>'hunted'</em>by a person or organization could be a plot-twist, a quest of it's own, or just make for very interesting situations to see how they play out. Having it done right away and everyone<em>'knowing'</em>about it is better than if we're surrounded by a hord of orcs or something, next time she might sneeze hide and wait for her to handle them all.