Well, it's a D&D world. The head of the church in the capital's an Aasimar, elves are fairly frequently seen, giants used to roam the forests north of Drellin's Ferry, and a lich lives in the wastelands to the south. Now, as for the snake-girl, she's going to have an automatic prejudice, as there's a city of Yuan-ti not *that* far away from the setting, just north of the main map of the campaign. Even if she's NOT Yuan-ti, most people are going to know snake-people are bad. Tieflings, too, will have similar prejudices... but, on the other hand, as low-mid level heroes, considering that the party could wipe out the entire village, even the size of Drellin's Ferry, if crossed, people aren't going to be up front confrontational about it.