To keep true to the source material I'd suggest the setting (at least) starts where ever Jefe's character resides.  I've already set up Sachiko to "stumble over" the trail of the DREAD Space Pirate Ryari, so those two characters falling into Jefe's lap will be cakework.<br/><br/>I'm sure Jefe's background will bring up interesting ideas as to what kind of situations to launch with.   ;D