Depending on how TheLaughingOne wants to play it I could see Orin and his character having crossed paths at least. That honestly goes for any character. I purposely left the more recent parts of Orin's backstory vague so that we can easily find ways for the characters to have crossed paths. Really anyone who has fought alongside/made use of traitor guardsmen or squads of cultists/heretics could have crossed Orin's path even if it's just been in passing.<br/><br/>I wouldn't be opposed to having him be somehow immune to Plaguemother's contagions. Depending on how 'prolific' you want to play her as it could set up a pretty amusing situation where she eventually decides to lay with one or more of Orin's squad mates/minions/followers to test if the protection extends to them as well. Only to find out nope it doesn't.