Here we have two different questions--what sort of campaign is this, and how many factions?<br/><br/>The 'default' is something like Firefly, with a bunch of PCs and their ship. There are also Grand Starship, Station, Colony, and City frameworks, and each has a slightly different feel.<br/><br/>As for Factions, the more Factions there are, the quieter the wars.<br/>A two or three faction game and you have clear good guy/bad guy divisions possible, and open conflict is simple and easy.<br/>At five or six, anyone trying to go full Palpatine is going to get crushed.  Bene Gesserit style, on the other hand, is standard.