I feel like point tracking NPC relationships is probably a little overkill. It slaps mechanics on things that are probably better left roleplayed.<br/><br/>I tend not to use reputation systems a whole lot myself (unless tightly woven into the setting's fabric, like Eclipse Phase). That said, I think reputation probably works best with specific factions. So, Justine may have reputation 5 with the City guard, but -3 with the Thieves' Guild or something like that.