Not automatically per se.  The way the faction adjustments work is that any faction directly negatively affected by your work takes a -1 to status per job you do.  So if the Red Sashes are at 0, the first job we do against them brings us down to -1.  Something major, like assassinating Mylera Klev, would drop us either to -2 or -3, depending on where we are.<br/><br/>Of course, that's why we took Misdirection.  We can make someone else take the fall for what we do.