Elusive mitochondrial connection to inflammation uncovered
Interesting post and comments, as usual. I wanted to give some pragmatic information related to this.<p>I have a genetic condition that makes my mitochondria to malfunction. I was diagnosed about 10 years ago. At first, I started taking supplements to increase the production of ATP, but my "vitality" did not improve much. I could workout normally, but my recovery ability was poor, and from time to time I would just crash and burn for 2-3 days.<p>After much reading, I came to the conclusion that the problem was not a shortage of ATP. Rather, it was the mess created by all the workarounds my body was doing to maintain a level of ATP that could keep me alive. So, I started taking the following pre-bed stack. It is meant to be a clean-up the mess, anti-inflammatory:<p>- 2g Vitamin C<p>- 500 mg reduced glutathione<p>- 500 mg curcumin (I prefer BCM-95)<p>- 1-5 mg melatonin (depending on activity level)<p>- 100 mg CoQ10<p>(I am also considering adding Ashwagandha to the stack)<p>As of today, I workout 4-5 times per week, with 2 sessions of boxing (like punching in the face, not the aerobic variation), 1 heavy lifting session (usually squats) and 1-2 metabolic circuit sessions.<p>Sure I feel tired at times, but it is not liked the deep, extreme fatigue I felt before starting this stack.<p>Hope this helps.