Anti-ageing compound set for human trials after turning clock back for mice
Okaaayyy... Can I buy NAD+? Or is the magic in using sIRNA[1] to inject NAD+ into the pathway?<p>I have read on Wikipedia that our body can generate it.<p>Moneyquote:
<i>"In organisms, NAD+ can be synthesized from simple building-blocks (de novo) from the amino acids tryptophan or aspartic acid. In an alternative fashion, more complex components of the coenzymes are taken up from food as the vitamin called niacin. Similar compounds are released by reactions that break down the structure of NAD+. These preformed components then pass through a salvage pathway that recycles them back into the active form. Some NAD+ is also converted into nicotinamide adenine dinucleotide phosphate (NADP+); the chemistry of this related coenzyme is similar to that of NAD+, but it has different roles in metabolism."</i> [2]<p>And: <i>"This NAD+ is carried into the mitochondrion by a specific membrane transport protein, since the coenzyme cannot diffuse across membranes."</i> Link: <a href="http://www.jbc.org/content/281/3/1524" rel="nofollow">http://www.jbc.org/content/281/3/1524</a> <a href="http://www.ncbi.nlm.nih.gov/pubmed/16291748" rel="nofollow">http://www.ncbi.nlm.nih.gov/pubmed/16291748</a><p>I can buy Tryptophan [3] and D-Aspartic Acid (DAA) [4] pretty easily and legaly. Would an overdose in Tryptophan have the same effect? UPDATE: <a href="http://aminoacidstudies.org/l-tryptophan/" rel="nofollow">http://aminoacidstudies.org/l-tryptophan/</a> Yes, Tryptophan overdose is bad!<p>I'm sorry, I'm pretty good at absorbing all kinds of scientific materials, but I am really not familiar with all the "body science". That's why I'm asking you, if you know what would happen with regular Tryptophan overdose. I know that DAA can destroy Neurons when overdosed and should only be used according to the RDA.<p>I don't buy that it's sooo expensive. That's either because researcher's monthly wage is astronomers, or the lab equipment they think is needed is too expensive. I am sure it can be done much much cheaper without the advantages of mass production. You and I currently synthesize the NAD+ thing for free!! The problem they solved, should be repeatable with cheaper equipment or even at home. I would like to have a cat, dog, hamsters or fish that live longer. (Parrot's already live pretty long, but I guess they'd be funnier with more NAD too)
--<p>[1] <a href="http://en.wikipedia.org/wiki/Small_interfering_RNA" rel="nofollow">http://en.wikipedia.org/wiki/Small_interfering_RNA</a><p>[2] <a href="http://en.wikipedia.org/wiki/Nicotinamide_adenine_dinucleotide" rel="nofollow">http://en.wikipedia.org/wiki/Nicotinamide_adenine_dinucleoti...</a><p>[3] <a href="http://en.wikipedia.org/wiki/Tryptophan" rel="nofollow">http://en.wikipedia.org/wiki/Tryptophan</a><p>[4] <a href="http://en.wikipedia.org/wiki/D-aspartic_acid" rel="nofollow">http://en.wikipedia.org/wiki/D-aspartic_acid</a>