Deep sleep may be the best defense against Alzheimer’s
I've posted this before, but it's worth repeating.<p>I recently discovered that I’m a slow metabolizer of caffeine. Via my raw 23andme data.
<a href="https://you.23andme.com/tools/data/?query=rs762551" rel="nofollow">https://you.23andme.com/tools/data/?query=rs762551</a><p>C/C genotype.<p><a href="https://www.geneticlifehacks.com/liver-detox-genes-cyp1a2/#C" rel="nofollow">https://www.geneticlifehacks.com/liver-detox-genes-cyp1a2/#C</a>...<p>Instead of coffee being a net positive, it actually takes caffeine 4X the time to process through my body. It also increases my cardiac event risk (most normal metabolizers it does not).<p>I can drink a cup of coffee at 8am and it still impacts my sleep the following night. My blood pressure remains really elevated (20+ points for systolic) the entire day.<p>All these decades I’ve been ingesting coffee thinking it’s a “net positive” - not for my genotype.<p>When the reality is I sleep like shit, my blood pressure is through the roof, I feel awful for a day or two of drinking a single cup, and it all makes sense now.<p>Even with just 30mg ingested this morning at 8am, I still feel very wide awake at 9pm.<p>When I totally detox from caffeine, go through the headaches, I ultimately feel calmer, and I get the best, deepest sleep.