One man's rare Alzheimer’s mutation delayed its onset
Really frustrating there is no open access to this paper.<p>I carry four (as far as I know) rare and low frequency homozygous minor allele SNPs in RELN:<p>rs39335(G;G)<p>rs3914132(C;C)<p>rs7696175(C;C)<p>rs4298437(T;T)<p>And guess what? I have Bipolar Disorder Schizoaffective type and my therapists keep telling me I have Aspergers.<p>This gene seems to bind to zinc, and a deficiency of zinc is also found in Alzheimer's.<p><a href="https://www.jneurosci.org/content/41/13/3025#:~:text=Inflammatory%20lifestyle%20factors%20increase%20the,evidence%20for%20this%20is%20limited" rel="nofollow">https://www.jneurosci.org/content/41/13/3025#:~:text=Inflamm...</a>.<p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3010690/" rel="nofollow">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3010690/</a><p><a href="https://alzres.biomedcentral.com/articles/10.1186/s13195-021-00931-3" rel="nofollow">https://alzres.biomedcentral.com/articles/10.1186/s13195-021...</a><p>Zinc has helped me in many ways.<p>Since the mutation is a GAIN OF FUNCTION mutation, more zinc means less risk of Alzheimer's.