Coronavirus Causes Damaging Blood Clots from Brain to Toes
So this is extremely interesting, because recently several studies have shown an association between low Vitamin D levels and severe COVID-19 outcomes. This is particularly relevant, because Vitamin D appears to play a role in clotting factors as well; low Vitamin D levels have been independently associated with an increased risk of clotting events and death. There are studies investigating whether Vitamin D deficiency can cause increased thrombin generation and a hypercoagulable state.<p>"Of 49 patients with mild symptoms of Covid-19 in three hospitals in southern Asian countries, only two had low levels of vitamin D; of 104 patients with critical or severe symptoms, only four did not have low levels of vitamin D."
<a href="https://www.telegraph.co.uk/news/2020/05/03/time-take-seriously-link-vitamin-d-deficiency-serious-covid/" rel="nofollow">https://www.telegraph.co.uk/news/2020/05/03/time-take-seriou...</a><p>"The VDI (Vitamin D Insufficiency) prevalence in ICU patients was 84.6%, vs. 57.1% in floor patients. Strikingly, 100% of ICU patients less than 75 years old had VDI. Coagulopathy was present in 62.5% of ICU COVID-19 patients, and 92.3% were lymphocytopenic. Conclusions: VDI is highly prevalent in severe COVID-19 patients"
<a href="https://www.medrxiv.org/content/10.1101/2020.04.24.20075838v1" rel="nofollow">https://www.medrxiv.org/content/10.1101/2020.04.24.20075838v...</a><p>"Vitamin D has been shown to have an anticoagulant effect. A decrease in 25-hydroxyvitamin D [25(OH)D] concentration has also been associated with an increased risk of venous thromboembolism. "
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069050/" rel="nofollow">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069050/</a><p>There is also other literature suggesting that Vitamin D can reduce the risk for the "cytokine storm" which leads to acute respiratory distress syndrome by reducing the production of pro-inflammatory cytokines (while increasing the expression of anti-inflammatory cytokines). Again, I'm not a doctor but supplementation is likely to be fairly low risk. There is increasing evidence that there's some sort of correlation and it may be worth exploring.