The Degradation Drug
The article describes its first subject as having been diagnosed with simply "depression", but describes their medication regime as including lithium and lamotrigine which in combination is strongly suggestive of treatment for bipolar depression in particular. Given that the described behavior sounds very much like a manic episode, the article should have explained this connection before attempting to focus the blame on pramipexole.<p>Most antidepressants, even SSRIs, are medically recognized as potentially triggering mania in bipolar patients. While compulsive gambling and hypersexuality are associated with dopamine agonists, I think it may be misleading for the article to focus so heavily on a possible manic episode without discussing bipolar disorder at all and while implying that this was a unique effect of dopamine agonists.