A broad-spectrum synthetic antibiotic that does not evoke bacterial resistance
The WHO &quot;Conceptual Zero Draft&quot; pandemic treaty from the 4th WHO INB meeting in Feb 2023 has multiple sections on bacterial resistance.  If this is signed by 196 countries in May 2024, there may be new funding for research.<p><a href="https:&#x2F;&#x2F;inb.who.int&#x2F;home&#x2F;inb-process" rel="nofollow">https:&#x2F;&#x2F;inb.who.int&#x2F;home&#x2F;inb-process</a><p><i>&gt; In December 2021, WHO’s Member States decided at a special session of the World Health Assembly to establish an intergovernmental negotiating body (INB), representing all regions of the world, to draft and negotiate a WHO convention, agreement, or other international instrument on pandemic prevention, preparedness and response</i><p><a href="https:&#x2F;&#x2F;apps.who.int&#x2F;gb&#x2F;inb&#x2F;pdf_files&#x2F;inb4&#x2F;A_INB4_3-en.pdf" rel="nofollow">https:&#x2F;&#x2F;apps.who.int&#x2F;gb&#x2F;inb&#x2F;pdf_files&#x2F;inb4&#x2F;A_INB4_3-en.pdf</a><p><pre><code>   25.  Noting that antimicrobial resistance is often described as a silent pandemic and that it could be an aggravating factor during a pandemic, 

   Article 4
   14. One Health – Multisectoral and transdisciplinary actions should recognize the interconnection between people, animals, plants and their shared environment, for which a coherent, integrated and unifying approach should be strengthened and applied with an aim to sustainably balance and optimize the health of people, animals and ecosystems, including through, but not limited to, attention to the prevention of epidemics due to pathogens resistant to antimicrobial agents and zoonotic diseases. 

  Article 9
  4. Each Party should encourage non-State actors to participate in and accelerate innovative research and development for addressing novel pathogens, pathogens resistant to antimicrobial agents and emerging and re-emerging diseases with pandemic potential. 

  Article 18
  3. The Parties will identify and integrate into relevant pandemic prevention and preparedness plans interventions that address the drivers of the emergence and re-emergence of disease at the human-animal-environment interface, including but not limited to climate change, land use change, wildlife trade, desertification and antimicrobial resistance. 

  7. (a) implement actions to prevent pandemics from pathogens resistant to antimicrobial agents, taking into account relevant tools and guidelines, through a One Health approach, and collaborate with relevant partners, including the Quadripartite; 

  7. (b) foster actions at national and community levels that encompass whole-of-government and whole-of-society approaches to control zoonotic outbreaks (in wildlife and domesticated animals), including engagement of communities in surveillance that identifies zoonotic outbreaks and antimicrobial resistance at source; 

  7. (c) develop and implement a national One Health action plan on antimicrobial resistance that strengthens antimicrobial stewardship in the human and animal sectors, optimizes antimicrobial consumption, increases investment in, and promotes equitable and affordable access to, new medicines, diagnostic tools, vaccines and other interventions, strengthens infection prevention and control in health care settings and sanitation and biosecurity in livestock farms, and provides technical support to developing countries; 

  7. (d) enhance surveillance to identify and report on pathogens resistant to antimicrobial agents in humans, livestock and aquaculture that have pandemic potential, building on the existing global reporting systems;</code></pre>