Long Covid risk falls only slightly after vaccination, study shows
I am wondering how much immune &quot;budget&quot; do humans have for vaccines?
This topic is left unadressed and is extremely worrying, being an existential risk.
Basically, the body has a limited amount of unspecialized naive T cells in its lifetime, mostly located&#x2F;modulated in the thymus gland, which involute quickly with age.<p>I suppose that 1) vaccines increase the rate of specialisation of naive T cells to mature t cells (hence the number of naive t cells diminish supraphysically)and I also believe that<p>2) those specific mature T cells, generating covid spike protein specific antibodies, have lost some or total ability to fight non-covid diseases as a cost of specialization.
1) would increase thymus involution rate and therefore age speed of immunosupression.<p>2) would reduce generic immune ability (learning other pathogens)<p>3) I believe the increased immune profile after a vaccine induce a long lasting (at least 6 month) increase of accelerated aging process in humans, via increased inflammation and therefore apoptosis, DNA mutations and oxidative stress, although in a mild form and hence in the medium term asymptomatic.<p>Above all the premises I enumerated, the 2) is the one I would draw the most attention to, which can be reformulated as:
do the repetitive administrations of a vaccine (here the 3 mRNA doses), reduce the effectiveness of the immune system for future non-COVID diseases, and even more importantly, does those doses reduce the immune learnability budget and therefore do those vaccines reduce the effectiveness of future vaccines against the next non-COVID pandemic?
There has to be a limit to immune memory, the question is, after how many vaccines do the effect become non-negligible on aging?<p>study backing chronic inflammation and therefore accelerated aging:
&gt; vaccine-induced hypermetabolic lymph nodes
<a href="https:&#x2F;&#x2F;pubmed.ncbi.nlm.nih.gov&#x2F;34857663&#x2F;" rel="nofollow">https:&#x2F;&#x2F;pubmed.ncbi.nlm.nih.gov&#x2F;34857663&#x2F;</a><p>study backing the depletion of lymphocite T helper cell production:
Study Shows Immune Cells Against Covid-19 Stay High in Number Six Months After Vaccination
<a href="https:&#x2F;&#x2F;www.hopkinsmedicine.org&#x2F;news&#x2F;newsroom&#x2F;news-releases&#x2F;study-shows-immune-cells-against-covid-19-stay-high-in-number-six-months-after-vaccination#:~:text=Study Shows Immune,who are unvaccinated" rel="nofollow">https:&#x2F;&#x2F;www.hopkinsmedicine.org&#x2F;news&#x2F;newsroom&#x2F;news-releases&#x2F;...</a>.<p>Moreover, I have an issue understanding why would vaccine not massively lose effectiveness after the age of 70 since at 70 the thymus has ~completely involuted (although maybe the stem cells in the bone marrow suffice?).