Prenatal THC exposure yields hyperdopaminergic phenotype rescued by pregnenolone
I&#x27;m not a neuroscientist, I&#x27;m not a smoker, and I&#x27;m not a woman. The headline result seems like it could be plausible. However...<p>My first instinct reading the abstract is that the conclusion which finds an effect on male rats and not female rats is an unjustified subgroup analysis and likely a spurious result.<p>Given the sexiness of the topic (people think weed is harmless, but what if it&#x27;s not), publication filters for stat. sig results, low a priori power, no adjustment for multiple comparisons, no pre-registration, and this bizarre subgroup contingent result... should we expect this to replicate?<p>Is there a strong theoretical basis for expecting the subgroup heterogeneity?