Moderna’s HIV vaccine has officially begun human trials
As I understand it, the reason an HIV vaccine has been so difficult to create is that HIV mutates so easily. I understand the basics behind how mRNA vaccines are generated, but I don&#x27;t understand why this approach would be expected to have any more success in evading the high mutation potential of HIV than other vaccine types. After all, it was even a concern with new coronavirus variants that the original Moderna vaccine would be less effective against them (and, indeed, while the original vaccine <i>is</i> still highly effective against all variants, my understanding is that it is less so than the original variant). And SARS-COV-2 mutates much less easily than HIV.<p>Can someone with more knowledge explain the thought process behind this?