Tetradecanoylphorbol Acetate
5-HT1A and histamine H1 receptors in HeLa cells stimulate phosphoinositide hydrolysis and phosphate uptake via distinct G protein pools.
A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes.
A distinct pattern of cytokine gene expression by human CD83+ blood dendritic cells.
A factor with a zinc- and phorbol ester-binding domain is necessary for endosome fusion.
A leukocyte lipid up-regulates the avidity of lymphocyte function-associated antigen-1.
A mechanism-based antioxidant approach for the reduction of skin carcinogenesis.
A novel mechanism of skin tumor promotion involving interferon-gamma (IFNγ)/signal transducer and activator of transcription-1 (Stat1) signaling.
A phorbol ester-binding protein is required downstream of Rab5 in endosome fusion.
A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling.
A soluble factor(s) secreted from CD8(+) T lymphocytes inhibits human immunodeficiency virus type 1 replication through STAT1 activation.
A synthetic peptide homologous to retroviral transmembrane envelope proteins depresses protein kinase C mediated lymphocyte proliferation and directly inactivated protein kinase C: a potential mechanism for immunosuppression.
Acetyl-CoA:1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase is directly activated by p38 kinase.
Activated T lymphocytes regulate hyaluronan binding to monocyte CD44 via production of IL-2 and IFN-gamma.
Activation of human granulocytes by arachidonic acid: its use and limitations for investigating granulocyte functions.
Activation of messenger-independent protein kinases in wild-type and phorbol ester-resistant EL4 thymoma cells.
Activation of neutrophil superoxide production by concanavalin A can occur at low levels of intracellular ionized calcium.
Activation of the respiratory burst enzyme in human polymorphonuclear leukocytes by chemoattractants and other soluble stimuli. Evidence that the same oxidase is activated by different transductional mechanisms.
Activity and activation of the granulocyte superoxide-generating system.
Adducin is an in vivo substrate for protein kinase C: phosphorylation in the MARCKS-related domain inhibits activity in promoting spectrin-actin complexes and occurs in many cells, including dendritic spines of neurons.
Adducin: Ca++-dependent association with sites of cell-cell contact.
Age-related increase in phorbol myristate acetate-induced lymphocyte adhesion to vascular endothelium.
Agonist-dependent phosphorylation of the mouse delta-opioid receptor: involvement of G protein-coupled receptor kinases but not protein kinase C.
Alpha-adducin dissociates from F-actin and spectrin during platelet activation.
Alterations in calcium metabolism in murine macrophages by the benzene metabolite 1,4-benzoquinone.
Alterations in stimulus-induced integrin expression in peripheral blood neutrophils of patients with diabetic retinopathy.
Altered cytoplasmic/nuclear distribution of the c-myc protein in differentiating ML-1 human myeloid leukemia cells.
Altered genetic response to beta-adrenergic receptor activation in late passage C6 glioma cells.
Aluminum-induced DNA synthesis in osteoblasts: mediation by a G-protein coupled cation sensing mechanism.
An endogenous source of the superoxide anion in the central nervous system.
Analysis of calcium homeostasis in activated human polymorphonuclear leukocytes. Evidence for two distinct mechanisms for lowering cytosolic calcium.
Anti-c-myc DNA increases differentiation and decreases colony formation by HL-60 cells.
Antibody valence and induced signal transduction: the role of antibody valence in anti-CD3-induced signal transduction in isolated normal T cells.
Basic fibroblast growth factor regulates the conversion of pro-luteinizing hormone-releasing hormone (Pro-LHRH) to LHRH in immortalized hypothalamic neurons.
Benzo(a)pyrene inhibits expression of inducible heat shock protein 70 in vascular endothelial cells.
CD4 binding to major histocompatibility complex class II antigens induces LFA-1-dependent and -independent homotypic adhesion of B lymphocytes.
CYLD inhibits tumorigenesis and metastasis by blocking JNK/AP1 signaling at multiple levels.
Caspase-3 promotes genetic instability and carcinogenesis.
Cdk2 deficiency decreases ras/CDK4-dependent malignant progression, but not myc-induced tumorigenesis.
Changes in actin state and chemotactic peptide receptor expression in granulocytes during cytokine administration after autologous bone marrow transplantation.
Characterization of differences between rapid agonist-dependent phosphorylation and phorbol ester-mediated phosphorylation of human substance P receptor in intact cells.
Chemical skin carcinogenesis is prevented in mice by the induced expression of a TGF-beta related transgene.
Chemoattractant receptors activate distinct pathways for chemotaxis and secretion. Role of G-protein usage.
Chemoattractant-induced activation of c-fos gene expression in human monocytes.
Chemoattractant-mediated stimulation of the respiratory burst in human polymorphonuclear leukocytes may require appearance of protein kinase activity in the cells' particulate fraction.
Class I restricted CTL recognition of a soluble protein delivered by liposomes containing lipophilic polylysines.
Clinical trials with human tumor necrosis factor: in vivo and in vitro effects on human mononuclear phagocyte function.
Cloning and characterization of the major promoter of the human protein kinase C beta gene. Regulation by phorbol esters.
Comparison of in vitro and in vivo differentiation of myeloblastic leukemia of the RFM/Un mouse.
Cooperative effect of tumor necrosis factor and gamma-interferon on chemotactic peptide receptor expression and stimulus-induced actin polymerization in HL-60 cells.
Correlation between membrane potential changes and superoxide production in human granulocytes stimulated by phorbol myristate acetate. Evidence for defective activation in chronic granulomatous disease.
Cross-desensitization among receptors for platelet activating factor and peptide chemoattractants. Evidence for independent regulatory pathways.
Cross-desensitization of receptors for peptide chemoattractants. Characterization of a new form of leukocyte regulation.
Cross-talk between cellular signalling pathways suggested by phorbol-ester-induced adenylate cyclase phosphorylation.
Cytochemical detection of superoxide in cerebral inflammation and ischemia in vivo.
Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesis.
Degradation of the Met tyrosine kinase receptor by the ubiquitin-proteasome pathway.
Development of a rapid whole blood flow cytometry procedure for the diagnosis of X-linked hyper-IgM syndrome patients and carriers.
Differences in phosphorylation of formylpeptide and C5a chemoattractant receptors correlate with differences in desensitization.
Differential effects of sphingomyelin hydrolysis and resynthesis on the activation of NF-kappa B in normal and SV40-transformed human fibroblasts.
Differential isoform-specific regulation of calcium-independent protein kinase C in rat cerebral cortex.
Does thalidomide affect IL-2 response and production?
ETS transcription factors regulate an enhancer activity in the third intron of TNF-alpha.
Effect of cyclooxygenase inhibitors and protease inhibitors on phorbol-induced stimulation of oxygen consumption and superoxide production by rat pulmonary macrophages.
Effect of protein kinase C inhibitors and activators on corneal re-epithelialization in the rat.
Effect of vasoactive intestinal peptide (VIP) on cytokine production and expression of VIP receptors in thymocyte subsets.
Electron transport complex I is required for CD8+ T cell function.
Elevated beta-cell calmodulin produces a unique insulin secretory defect in transgenic mice.
Endogenous protein kinase-C activation in osteoblast-like cells modulates responsiveness to estrogen and estrogen receptor levels.
Endotoxin-mediated synthesis of nitric oxide is dependent on Gq protein signal transduction.
Enhanced production of superoxide anion by microglia from trisomy 16 mice.
Epidermal growth factor, vanadate, and 12-O-tetradecanoylphorbol-13-acetate inhibit growth and stimulate prostaglandin E2 production in A431 cells.
Evidence for distinct intracellular pools of receptors for C3b and C3bi in human neutrophils.
Expression of protein kinase C isozymes in nonpregnant and pregnant human myometrium.
Expression of the human leukocyte adhesion molecule, LAM1. Identity with the TQ1 and Leu-8 differentiation antigens.
Expression, distribution, and biochemistry of human CD39. Role in activation-associated homotypic adhesion of lymphocytes.
Functional impairment in protein kinase C by RACK1 (receptor for activated C kinase 1) deficiency in aged rat brain cortex.
Functional inactivation and structural disruption of human alpha 2-macroglobulin by neutrophils and eosinophils.
G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein.
Glycoprotein B of human herpesvirus 8 is a component of the virion in a cleaved form composed of amino- and carboxyl-terminal fragments.
Growth arrest of human B lymphocytes is accompanied by induction of the low molecular weight mammalian heat shock protein (Hsp28).
Heat shock protein is a unique marker of growth arrest during macrophage differentiation of HL-60 cells.
Identification of a defect in the phospholipase D/diacylglycerol pathway in cellular senescence.
Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation.
In vitro inhibition of murine IFN gamma production by phosphorothioate deoxyguanosine oligomers.
Increased accumulation of tissue ACE in human atherosclerotic coronary artery disease.
Induction of T cell CD7 gene transcription by nonmitogenic ionomycin-induced transmembrane calcium flux.
Induction of superoxide anion and nitric oxide production in cultured microglia.
Inhibition of microglial superoxide anion production by isoproterenol and dexamethasone.
Inhibition of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) messenger RNA (mRNA) expression in HL-60 leukemia cells by pentoxifylline and dexamethasone: dissociation of acivicin-induced TNF-alpha and IL-1 beta mRNA expression from acivicin-induced monocytoid differentiation.
Insulin activates a novel adipocyte mitogen-activated protein kinase kinase kinase that shows rapid phasic kinetics and is distinct from c-Raf.
Insulin and phorbol ester stimulate phosphorylation of acetyl-CoA carboxylase at similar sites in isolated adipocytes. Lack of correspondence with sites phosphorylated on the purified enzyme by protein kinase C.
Interaction of atrial natriuretic polypeptide and angiotensin II on protooncogene expression and vascular cell growth.
Interleukin-15 augments superoxide production and microbicidal activity of human monocytes against Candida albicans.
Intracellular CMTM2 negatively regulates human immunodeficiency virus type-1 transcription through targeting the transcription factors AP-1 and CREB.
Levels of p53 protein increase with maturation in human hematopoietic cells.
Lipopolysaccharide and phorbol esters induce differentiation but have opposite effects on phosphatidylinositol turnover and Ca2+ mobilization in 70Z/3 pre-B lymphocytes.
Long-chain (sphingoid) bases inhibit multistage carcinogenesis in mouse C3H/10T1/2 cells treated with radiation and phorbol 12-myristate 13-acetate.
Lymphoma models for B cell activation and tolerance. V. Anti-Ig mediated growth inhibition is reversed by phorbol myristate acetate but does not involve changes in cytosolic free calcium.
MARCKS and HSP70 interactions regulate mucin secretion by human airway epithelial cells in vitro.
Mast cell-derived particles deliver peripheral signals to remote lymph nodes.
Mechanism of differentiation of human erythroleukaemic cell line K562 by hemin.
Mechanisms of regulating the respiratory burst in leukocytes.
Minimal and inducible regulation of tissue factor pathway inhibitor-2 in human gliomas.
Mitogen-activated protein kinases enhance long-range activation by the beta-globin locus control region.
Modulation of endothelial cell morphogenesis in vitro by MMP-9 during glial-endothelial cell interactions.
Modulation of the free sphingosine levels in human neutrophils by phorbol esters and other factors.
Molecular signals in B cell activation. I. Differential refractory effects of incomplete signaling by ionomycin or PMA relate to autocrine IL-2 production and IL-2R expression.
Molecular signals in B cell activation. II. IL-2-mediated signals are required in late G1 for transition to S phase after ionomycin and PMA treatment.
Myogenic constriction of human coronary arterioles.
Normal cellular and transformation-associated abl proteins share common sites for protein kinase C phosphorylation.
Nuclear expression of the 50- and 65-kD Rel-related subunits of nuclear factor-kappa B is differentially regulated in human monocytic cells.
Nucleotide regulatory protein-mediated activation of phospholipase C in human polymorphonuclear leukocytes is disrupted by phorbol esters.
Phorbol diester treatment promotes enhanced adenylate cyclase activity in frog erythrocytes.
Phorbol diester-induced H2O2 production by peritoneal macrophages. Different H2O2 production by macrophages from normal and BCG-infected mice despite comparable phorbol diester receptors.
Phorbol ester effects on alpha 1-adrenoceptor binding and phosphatidylinositol metabolism in cultured vascular smooth muscle cells.
Phorbol ester inhibits granulocyte-macrophage colony-stimulating factor binding and tyrosine phosphorylation.
Phorbol ester promotes endocytosis by activating a factor involved in endosome fusion.
Phorbol esters down-regulate protein kinase C in rat brain cerebral cortical slices.
Phorbol esters enhance neurotransmitter-stimulated cyclic AMP production in rat brain slices.
Phorbol esters induce differentiation in a pre-B-lymphocyte cell line by enhancing Na+/H+ exchange.
Phorbol esters promote alpha 1-adrenergic receptor phosphorylation and receptor uncoupling from inositol phospholipid metabolism.
Phorbol myristate acetate mediates redistribution of protein kinase C in human neutrophils: potential role in the activation of the respiratory burst enzyme.
Phorbol myristate acetate stimulates microtubule and 10-nm filament extension and lysosome redistribution in mouse macrophages.
Phorbol myristate acetate stimulates pinocytosis and membrane spreading in mouse peritoneal macrophages.
Phosphorylation and desensitization of neurokinin-1 receptor expressed in epithelial cells.
Phosphorylation and desensitization of the human beta 1-adrenergic receptor. Involvement of G protein-coupled receptor kinases and cAMP-dependent protein kinase.
Phosphorylation of Gz in human platelets. Selectivity and site of modification.
Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility.
Phosphorylation of the B1 (CD20) molecule by normal and malignant human B lymphocytes.
Post-transcriptional inhibition of lipopolysaccharide-induced expression of inducible nitric oxide synthase by Gö6976 in murine microglia.
Preligand assembly domain-mediated ligand-independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis.
Production of superoxide anions by a CNS macrophage, the microglia.
Programmed cell death induced by ceramide.
Protein kinase C activates the renal apical membrane Na+/H+ exchanger.
Protein kinase C activity, translocation, and conventional isoforms in aging rat brain.
Protein kinase C and Ca2+ activation of mucin secretion in airway goblet cells.
Protein kinase C isoforms in human aortic smooth muscle cells.
Protein kinase C phosphorylates a recently identified membrane skeleton-associated calmodulin-binding protein in human erythrocytes.
Rapid activation and down-regulation of protein kinase C alpha in 12-O-Tetradecanoylphorbol-13-acetate-induced differentiation of human rhabdomyosarcoma cells.
Receptor class desensitization of leukocyte chemoattractant receptors.
Receptors and signaling mechanisms required for prostaglandin E2-mediated regulation of mast cell degranulation and IL-6 production.
Recombinant human gamma-interferon induces human monocyte polykaryon formation.
Regulation of T cell receptor- and CD28-induced tyrosine phosphorylation of the focal adhesion tyrosine kinases Pyk2 and Fak by protein kinase C. A role for protein tyrosine phosphatases.
Regulation of T cell receptor-induced activation of the Ras-ERK pathway by diacylglycerol kinase zeta.
Regulation of adrenergic receptor function by phosphorylation. I. Agonist-promoted desensitization and phosphorylation of alpha 1-adrenergic receptors coupled to inositol phospholipid metabolism in DDT1 MF-2 smooth muscle cells.
Regulation of arachidonic acid release in vascular endothelium. Ca(2+)-dependent and -independent pathways.
Regulation of gonadotropin-releasing hormone by protein kinase-A and -C in immortalized hypothalamic neurons.
Regulation of human CD44H and CD44E isoform binding to hyaluronan by phorbol myristate acetate and anti-CD44 monoclonal and polyclonal antibodies.
Regulation of human chemokine receptors CXCR4. Role of phosphorylation in desensitization and internalization.
Regulation of human interleukin-8 receptor A: identification of a phosphorylation site involved in modulating receptor functions.
Regulation of leukocyte adhesion molecule-1 (TQ1, Leu-8) expression and shedding by normal and malignant cells.
Regulatory mechanisms of a chemoattractant receptor on leukocytes.
Relationship between oxidative burst activity and CD11b expression in neutrophils and monocytes from healthy individuals: effects of race and gender.
Relationship of acivicin-induced monocytoid differentiation of human myeloid leukemia cells to acivicin-induced modulation of growth factor, cytokine, and protooncogene mRNA expression.
Ribosomal RACK1:Protein Kinase C βII Phosphorylates Eukaryotic Initiation Factor 4G1 at S1093 To Modulate Cap-Dependent and -Independent Translation Initiation.
Role of phospholipase Cbeta3 phosphorylation in the desensitization of cellular responses to platelet-activating factor.
Selective autoregulation of endothelins in primary astrocyte cultures: endothelin receptor-mediated potentiation of endothelin-1 secretion.
Selective regulation of expression of protein kinase C (PKC) isoenzymes in multidrug-resistant MCF-7 cells. Functional significance of enhanced expression of PKC alpha.
Selective regulation of protein kinase C isoenzymes by oleic acid in human platelets.
Sensitization of frog erythrocyte adenylate cyclase system by tumor-promoting phorbol diesters.
Serine phosphorylation of glutathione S-transferase P1 (GSTP1) by PKCα enhances GSTP1-dependent cisplatin metabolism and resistance in human glioma cells.
Specific receptors for phorbol diesters on freshly isolated human myeloid and lymphoid leukemia cells: comparable binding characteristics despite different cellular responses.
Stimulation of neutrophil oxidative metabolism by chemotactic peptides: influence of calcium ion concentration and cytochalasin B and comparison with stimulation by phorbol myristate acetate.
Stimulation of ovarian tumor cell proliferation with monocyte products including interleukin-1, interleukin-6, and tumor necrosis factor-alpha.
Stimulus-specific effects of pentoxifylline on neutrophil CR3 expression, degranulation, and superoxide production.
Structural requirements regulate endoproteolytic release of the L-selectin (CD62L) adhesion receptor from the cell surface of leukocytes.
Substance P and calcitonin gene-related peptide increase IL-1 beta, IL-6 and TNF alpha secretion from human peripheral blood mononuclear cells.
Synthetic peptide corresponding to a conserved domain of the retroviral protein p15E blocks IL-1-mediated signal transduction.
T cell activation up-regulates the expression of the focal adhesion kinase Pyk2: opposing roles for the activation of protein kinase C and the increase in intracellular Ca2+.
The B7-2 (B70) costimulatory molecule expressed by monocytes and activated B lymphocytes is the CD86 differentiation antigen.
The NADPH oxidase of human polymorphonuclear leukocytes. Evidence for regulation by multiple signals.
The NF-kappa B inhibitor, tepoxalin, suppresses surface expression of the cell adhesion molecules CD62E, CD11b/CD18 and CD106.
The indolocarbazole Gö6976 protects neurons from lipopolysaccharide/interferon-gamma-induced cytotoxicity in murine neuron/glia co-cultures.
The inhibition of differentiation caused by TGFbeta in fetal myoblasts is dependent upon selective expression of PKCtheta: a possible molecular basis for myoblast diversification during limb histogenesis.
The role of ion fluxes in hematopoietic cell differentiation.
Topical and oral administration of the natural water-soluble antioxidant from spinach reduces the multiplicity of papillomas in the Tg.AC mouse model.
Transfection of the CD20 cell surface molecule into ectopic cell types generates a Ca2+ conductance found constitutively in B lymphocytes.
Transmembrane signals generated through MHC class II, CD19, CD20, CD39, and CD40 antigens induce LFA-1-dependent and independent adhesion in human B cells through a tyrosine kinase-dependent pathway.
Tumor cell killing by phorbol ester--differentiated human leukemia cells.
Tumor-promoting phorbol esters induce rapid internalization of the C3b receptor via a cytoskeleton-dependent mechanism.
Two PKC consensus sites on human acid-sensing ion channel 1b differentially regulate its function.
Tyrosine phosphorylation in human neutrophil.
VEGF induces Tie2 shedding via a phosphoinositide 3-kinase/Akt dependent pathway to modulate Tie2 signaling.
VEGF is essential for hypoxia-inducible factor-mediated neovascularization but dispensable for endothelial sprouting.
Vascular smooth muscle cell hypertrophy vs. hyperplasia. Autocrine transforming growth factor-beta 1 expression determines growth response to angiotensin II.
cAMP stimulates transcription of the beta 2-adrenergic receptor gene in response to short-term agonist exposure.
p53 translocation to mitochondria precedes its nuclear translocation and targets mitochondrial oxidative defense protein-manganese superoxide dismutase.
Linardic, Corinne Mary, Associate Professor of Pediatrics, Pharmacology & Cancer Biology