Type 1/type 2 cytokine modulation of T-cell programed cell death as a model for human immunodeficiency virus pathogenesis
Mario Clerici, Apurva Sarin, Robert L. Coffman, Thomas A. Wynn, Stephen P. Blatt, Craig W. Hendrix, Stanley F. Wolf, Gene M. Shearer, Pierre A. Henkart
Fondazione Don Carlo Gnocchi Onlus
In vitro T-cell receptor-induced programed cell death in both activated T cells from human immunodeficiency virus-seronegative (HIV-) donors and resting T cells from HIV+ donors was substantially influenced by cytokines. Addition of exogenous recombinant 'type 1' lymphokines interferon γ and interleukin 2 (IL-2), as well as the macrophage-produced IL-12, which favor cell-mediated T-cell responses, blocks both systems of T-lymphocyte programed cell death. In contrast, the 'type 2' lymphokines IL-4 and IL-10, which favor antibody responses, either had no effect or enhanced these systems of in vitro T-cell programed cell death. A role for endogenously produced cytokines was suggested by the inhibition of T-cell receptor-mediated death by antibodies against IL-4 and IL-10 and its enhancement by anti-IL-12 in cultures containing monocytes. These results demonstrate that the functional properties of type 1 and type 2 cytokine classes may be further extended to include their effects on T-cell programed cell death and their possible role in the pathogenesis of HIV infection.
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HIV Medicine & Life Sciences 100%
Cytokines Medicine & Life Sciences 89%
T-Lymphocytes Medicine & Life Sciences 89%
Apoptosis Medicine & Life Sciences 88%
Lymphokines Medicine & Life Sciences 57%
Interleukin-12 Medicine & Life Sciences 49%
T-Cell Antigen Receptor Medicine & Life Sciences 49%
Interleukin-4 Medicine & Life Sciences 44%
Clerici, M., Sarin, A., Coffman, R. L., Wynn, T. A., Blatt, S. P., Hendrix, C. W., Wolf, S. F., Shearer, G. M., & Henkart, P. A. (1994). Type 1/type 2 cytokine modulation of T-cell programed cell death as a model for human immunodeficiency virus pathogenesis. Proceedings of the National Academy of Sciences of the United States of America, 91(25), 11811-11815. https://doi.org/10.1073/pnas.91.25.11811
Type 1/type 2 cytokine modulation of T-cell programed cell death as a model for human immunodeficiency virus pathogenesis. / Clerici, Mario; Sarin, Apurva; Coffman, Robert L. et al.
Clerici, M, Sarin, A, Coffman, RL, Wynn, TA, Blatt, SP, Hendrix, CW, Wolf, SF, Shearer, GM & Henkart, PA 1994, 'Type 1/type 2 cytokine modulation of T-cell programed cell death as a model for human immunodeficiency virus pathogenesis', Proceedings of the National Academy of Sciences of the United States of America, vol. 91, no. 25, pp. 11811-11815. https://doi.org/10.1073/pnas.91.25.11811
Clerici M, Sarin A, Coffman RL, Wynn TA, Blatt SP, Hendrix CW et al. Type 1/type 2 cytokine modulation of T-cell programed cell death as a model for human immunodeficiency virus pathogenesis. Proceedings of the National Academy of Sciences of the United States of America. 1994 Dec 6;91(25):11811-11815. doi: 10.1073/pnas.91.25.11811
Clerici, Mario ; Sarin, Apurva ; Coffman, Robert L. et al. / Type 1/type 2 cytokine modulation of T-cell programed cell death as a model for human immunodeficiency virus pathogenesis. In: Proceedings of the National Academy of Sciences of the United States of America. 1994 ; Vol. 91, No. 25. pp. 11811-11815.
@article{6bff4ac499674aa1bc2867b21310d954,
title = "Type 1/type 2 cytokine modulation of T-cell programed cell death as a model for human immunodeficiency virus pathogenesis",
abstract = "In vitro T-cell receptor-induced programed cell death in both activated T cells from human immunodeficiency virus-seronegative (HIV-) donors and resting T cells from HIV+ donors was substantially influenced by cytokines. Addition of exogenous recombinant 'type 1' lymphokines interferon γ and interleukin 2 (IL-2), as well as the macrophage-produced IL-12, which favor cell-mediated T-cell responses, blocks both systems of T-lymphocyte programed cell death. In contrast, the 'type 2' lymphokines IL-4 and IL-10, which favor antibody responses, either had no effect or enhanced these systems of in vitro T-cell programed cell death. A role for endogenously produced cytokines was suggested by the inhibition of T-cell receptor-mediated death by antibodies against IL-4 and IL-10 and its enhancement by anti-IL-12 in cultures containing monocytes. These results demonstrate that the functional properties of type 1 and type 2 cytokine classes may be further extended to include their effects on T-cell programed cell death and their possible role in the pathogenesis of HIV infection.",
author = "Mario Clerici and Apurva Sarin and Coffman, {Robert L.} and Wynn, {Thomas A.} and Blatt, {Stephen P.} and Hendrix, {Craig W.} and Wolf, {Stanley F.} and Shearer, {Gene M.} and Henkart, {Pierre A.}",
T1 - Type 1/type 2 cytokine modulation of T-cell programed cell death as a model for human immunodeficiency virus pathogenesis
AU - Clerici, Mario
AU - Sarin, Apurva
AU - Coffman, Robert L.
AU - Wynn, Thomas A.
AU - Blatt, Stephen P.
AU - Hendrix, Craig W.
AU - Wolf, Stanley F.
AU - Shearer, Gene M.
AU - Henkart, Pierre A.
N2 - In vitro T-cell receptor-induced programed cell death in both activated T cells from human immunodeficiency virus-seronegative (HIV-) donors and resting T cells from HIV+ donors was substantially influenced by cytokines. Addition of exogenous recombinant 'type 1' lymphokines interferon γ and interleukin 2 (IL-2), as well as the macrophage-produced IL-12, which favor cell-mediated T-cell responses, blocks both systems of T-lymphocyte programed cell death. In contrast, the 'type 2' lymphokines IL-4 and IL-10, which favor antibody responses, either had no effect or enhanced these systems of in vitro T-cell programed cell death. A role for endogenously produced cytokines was suggested by the inhibition of T-cell receptor-mediated death by antibodies against IL-4 and IL-10 and its enhancement by anti-IL-12 in cultures containing monocytes. These results demonstrate that the functional properties of type 1 and type 2 cytokine classes may be further extended to include their effects on T-cell programed cell death and their possible role in the pathogenesis of HIV infection.
AB - In vitro T-cell receptor-induced programed cell death in both activated T cells from human immunodeficiency virus-seronegative (HIV-) donors and resting T cells from HIV+ donors was substantially influenced by cytokines. Addition of exogenous recombinant 'type 1' lymphokines interferon γ and interleukin 2 (IL-2), as well as the macrophage-produced IL-12, which favor cell-mediated T-cell responses, blocks both systems of T-lymphocyte programed cell death. In contrast, the 'type 2' lymphokines IL-4 and IL-10, which favor antibody responses, either had no effect or enhanced these systems of in vitro T-cell programed cell death. A role for endogenously produced cytokines was suggested by the inhibition of T-cell receptor-mediated death by antibodies against IL-4 and IL-10 and its enhancement by anti-IL-12 in cultures containing monocytes. These results demonstrate that the functional properties of type 1 and type 2 cytokine classes may be further extended to include their effects on T-cell programed cell death and their possible role in the pathogenesis of HIV infection.