New method for assessing liver fibrosis based on acoustic radiation force impulse: A special reference to the difference between right and left liver
Takeo Toshima, Ken Shirabe, Kazuki Takeishi, Takashi Motomura, Youhei Mano, Hideaki Uchiyama, Tomoharu Yoshizumi, Yuji Soejima, Akinobu Taketomi, Yoshihiko Maehara
Liver Surgery
Department of Advanced Medicine and Innovative Technology
Background: Virtual touch tissue quantification (VTTQ) based on acoustic radiation force impulse (ARFI) imaging has been developed as a noninvasive bedside method for the assessment of liver stiffness. In this study, we examined the diagnostic performance of ARFI imaging in 103 patients, focusing on the difference in VTTQ values between the right and left liver lobes. Methods: We evaluated VTTQ values of the right and left lobes in 79 patients with chronic liver disease who underwent histological examination of liver fibrosis and in 24 healthy volunteers. The diagnostic accuracy of VTTQ was compared with several serum markers, including hyaluronic acid, type 4 collagen, and aspartate transaminase to platelet ratio index. Results: The VTTQ values (meters per second) in the right and left lobes were 1.61 ± 0.51 and 1.90 ± 0.68, respectively, and the difference was statistically significant (P < 0.0001). The VTTQ values in both liver lobes were correlated significantly with histological fibrosis grades (P < 0.001). The standard deviations of the VTTQ values in the right lobe were significantly lower than those in the left lobe (P < 0.001). The area under the receiver-operating characteristic curve for the diagnosis of fibrosis (F ≥ 3) using VTTQ values in both liver lobes was superior to serum markers, especially in the right lobe. Conclusions: VTTQ is an accurate and reliable tool for the assessment of liver fibrosis. VTTQ of the right lobe was more accurate for diagnosing liver fibrosis than in the left lobe.
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Touch Medicine & Life Sciences
Liver Cirrhosis Medicine & Life Sciences
Elasticity Imaging Techniques Medicine & Life Sciences
Fibrosis Medicine & Life Sciences
Toshima, T., Shirabe, K., Takeishi, K., Motomura, T., Mano, Y., Uchiyama, H., Yoshizumi, T., Soejima, Y., Taketomi, A., & Maehara, Y. (2011). New method for assessing liver fibrosis based on acoustic radiation force impulse: A special reference to the difference between right and left liver. Journal of gastroenterology, 46(5), 705-711. https://doi.org/10.1007/s00535-010-0365-7
New method for assessing liver fibrosis based on acoustic radiation force impulse : A special reference to the difference between right and left liver. / Toshima, Takeo; Shirabe, Ken; Takeishi, Kazuki; Motomura, Takashi; Mano, Youhei; Uchiyama, Hideaki; Yoshizumi, Tomoharu; Soejima, Yuji; Taketomi, Akinobu; Maehara, Yoshihiko.
In: Journal of gastroenterology, Vol. 46, No. 5, 05.2011, p. 705-711.
Toshima, T, Shirabe, K, Takeishi, K, Motomura, T, Mano, Y, Uchiyama, H, Yoshizumi, T, Soejima, Y, Taketomi, A & Maehara, Y 2011, 'New method for assessing liver fibrosis based on acoustic radiation force impulse: A special reference to the difference between right and left liver', Journal of gastroenterology, vol. 46, no. 5, pp. 705-711. https://doi.org/10.1007/s00535-010-0365-7
Toshima T, Shirabe K, Takeishi K, Motomura T, Mano Y, Uchiyama H et al. New method for assessing liver fibrosis based on acoustic radiation force impulse: A special reference to the difference between right and left liver. Journal of gastroenterology. 2011 May;46(5):705-711. https://doi.org/10.1007/s00535-010-0365-7
Toshima, Takeo ; Shirabe, Ken ; Takeishi, Kazuki ; Motomura, Takashi ; Mano, Youhei ; Uchiyama, Hideaki ; Yoshizumi, Tomoharu ; Soejima, Yuji ; Taketomi, Akinobu ; Maehara, Yoshihiko. / New method for assessing liver fibrosis based on acoustic radiation force impulse : A special reference to the difference between right and left liver. In: Journal of gastroenterology. 2011 ; Vol. 46, No. 5. pp. 705-711.
@article{366970e613f0403dbe38cd203f545d5b,
title = "New method for assessing liver fibrosis based on acoustic radiation force impulse: A special reference to the difference between right and left liver",
abstract = "Background: Virtual touch tissue quantification (VTTQ) based on acoustic radiation force impulse (ARFI) imaging has been developed as a noninvasive bedside method for the assessment of liver stiffness. In this study, we examined the diagnostic performance of ARFI imaging in 103 patients, focusing on the difference in VTTQ values between the right and left liver lobes. Methods: We evaluated VTTQ values of the right and left lobes in 79 patients with chronic liver disease who underwent histological examination of liver fibrosis and in 24 healthy volunteers. The diagnostic accuracy of VTTQ was compared with several serum markers, including hyaluronic acid, type 4 collagen, and aspartate transaminase to platelet ratio index. Results: The VTTQ values (meters per second) in the right and left lobes were 1.61 ± 0.51 and 1.90 ± 0.68, respectively, and the difference was statistically significant (P < 0.0001). The VTTQ values in both liver lobes were correlated significantly with histological fibrosis grades (P < 0.001). The standard deviations of the VTTQ values in the right lobe were significantly lower than those in the left lobe (P < 0.001). The area under the receiver-operating characteristic curve for the diagnosis of fibrosis (F ≥ 3) using VTTQ values in both liver lobes was superior to serum markers, especially in the right lobe. Conclusions: VTTQ is an accurate and reliable tool for the assessment of liver fibrosis. VTTQ of the right lobe was more accurate for diagnosing liver fibrosis than in the left lobe.",
author = "Takeo Toshima and Ken Shirabe and Kazuki Takeishi and Takashi Motomura and Youhei Mano and Hideaki Uchiyama and Tomoharu Yoshizumi and Yuji Soejima and Akinobu Taketomi and Yoshihiko Maehara",
journal = "Journal of Gastroenterology",
publisher = "Springer Japan",
T1 - New method for assessing liver fibrosis based on acoustic radiation force impulse
T2 - A special reference to the difference between right and left liver
AU - Toshima, Takeo
AU - Shirabe, Ken
AU - Takeishi, Kazuki
AU - Motomura, Takashi
AU - Mano, Youhei
AU - Uchiyama, Hideaki
AU - Yoshizumi, Tomoharu
AU - Soejima, Yuji
AU - Taketomi, Akinobu
AU - Maehara, Yoshihiko
N2 - Background: Virtual touch tissue quantification (VTTQ) based on acoustic radiation force impulse (ARFI) imaging has been developed as a noninvasive bedside method for the assessment of liver stiffness. In this study, we examined the diagnostic performance of ARFI imaging in 103 patients, focusing on the difference in VTTQ values between the right and left liver lobes. Methods: We evaluated VTTQ values of the right and left lobes in 79 patients with chronic liver disease who underwent histological examination of liver fibrosis and in 24 healthy volunteers. The diagnostic accuracy of VTTQ was compared with several serum markers, including hyaluronic acid, type 4 collagen, and aspartate transaminase to platelet ratio index. Results: The VTTQ values (meters per second) in the right and left lobes were 1.61 ± 0.51 and 1.90 ± 0.68, respectively, and the difference was statistically significant (P < 0.0001). The VTTQ values in both liver lobes were correlated significantly with histological fibrosis grades (P < 0.001). The standard deviations of the VTTQ values in the right lobe were significantly lower than those in the left lobe (P < 0.001). The area under the receiver-operating characteristic curve for the diagnosis of fibrosis (F ≥ 3) using VTTQ values in both liver lobes was superior to serum markers, especially in the right lobe. Conclusions: VTTQ is an accurate and reliable tool for the assessment of liver fibrosis. VTTQ of the right lobe was more accurate for diagnosing liver fibrosis than in the left lobe.
AB - Background: Virtual touch tissue quantification (VTTQ) based on acoustic radiation force impulse (ARFI) imaging has been developed as a noninvasive bedside method for the assessment of liver stiffness. In this study, we examined the diagnostic performance of ARFI imaging in 103 patients, focusing on the difference in VTTQ values between the right and left liver lobes. Methods: We evaluated VTTQ values of the right and left lobes in 79 patients with chronic liver disease who underwent histological examination of liver fibrosis and in 24 healthy volunteers. The diagnostic accuracy of VTTQ was compared with several serum markers, including hyaluronic acid, type 4 collagen, and aspartate transaminase to platelet ratio index. Results: The VTTQ values (meters per second) in the right and left lobes were 1.61 ± 0.51 and 1.90 ± 0.68, respectively, and the difference was statistically significant (P < 0.0001). The VTTQ values in both liver lobes were correlated significantly with histological fibrosis grades (P < 0.001). The standard deviations of the VTTQ values in the right lobe were significantly lower than those in the left lobe (P < 0.001). The area under the receiver-operating characteristic curve for the diagnosis of fibrosis (F ≥ 3) using VTTQ values in both liver lobes was superior to serum markers, especially in the right lobe. Conclusions: VTTQ is an accurate and reliable tool for the assessment of liver fibrosis. VTTQ of the right lobe was more accurate for diagnosing liver fibrosis than in the left lobe.
JO - Journal of Gastroenterology
JF - Journal of Gastroenterology